mRNA capping enzyme N-terminal, ATPase and guanylyltransferase; This domain is the N-terminus ...
26-333
8.18e-163
mRNA capping enzyme N-terminal, ATPase and guanylyltransferase; This domain is the N-terminus of the large subunit viral mRNA capping enzyme, and carries both the ATPase and the guanylyltransferase activities of the enzyme. The guanylyltransferase enzymatic region runs from residues 242 (leucine)-273(arginine), the core of the acitve site being the lysine residue at 260. The ATPase activity is at the very N-terminal part of the domain.
:
Pssm-ID: 287595 Cd Length: 311 Bit Score: 475.32 E-value: 8.18e-163
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
560-836
5.14e-129
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).
The actual alignment was detected with superfamily member pfam03291:
Pssm-ID: 473071 [Multi-domain] Cd Length: 332 Bit Score: 389.10 E-value: 5.14e-129
mRNA capping enzyme N-terminal, ATPase and guanylyltransferase; This domain is the N-terminus ...
26-333
8.18e-163
mRNA capping enzyme N-terminal, ATPase and guanylyltransferase; This domain is the N-terminus of the large subunit viral mRNA capping enzyme, and carries both the ATPase and the guanylyltransferase activities of the enzyme. The guanylyltransferase enzymatic region runs from residues 242 (leucine)-273(arginine), the core of the acitve site being the lysine residue at 260. The ATPase activity is at the very N-terminal part of the domain.
Pssm-ID: 287595 Cd Length: 311 Bit Score: 475.32 E-value: 8.18e-163
mRNA capping enzyme N-terminal, ATPase and guanylyltransferase; This domain is the N-terminus ...
26-333
8.18e-163
mRNA capping enzyme N-terminal, ATPase and guanylyltransferase; This domain is the N-terminus of the large subunit viral mRNA capping enzyme, and carries both the ATPase and the guanylyltransferase activities of the enzyme. The guanylyltransferase enzymatic region runs from residues 242 (leucine)-273(arginine), the core of the acitve site being the lysine residue at 260. The ATPase activity is at the very N-terminal part of the domain.
Pssm-ID: 287595 Cd Length: 311 Bit Score: 475.32 E-value: 8.18e-163
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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