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Conserved domains on  [gi|126466588|gb|ABO14018|]
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NADH dehydrogenase subunit 2 (mitochondrion) [Heterophallus milleri]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475913)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-346 1.31e-164

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 463.12  E-value: 1.31e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588   1 MTPIVLSTLIMSLGIGTTLTFTSTHWFLAWMGIEINTLAIIPLMTQDHSPRATEATTKYFFAQATASATLLFAATSNAFF 80
Cdd:MTH00135   1 MNPYVLTILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  81 TGSWDILQYNHPLSSSLLTLALAMKIGLAPLHSWMPEVMQGLNLLTALILSTWQKLAPMCLIYQIQPHNPMLIILLGLLS 160
Cdd:MTH00135  81 TGQWDIQQMSHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPTNPTLLITLGLTS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 161 IIMGGWGGFNQVQLRKILAYSSIAHLGWMVLILPFSSSLTLLAFATYLMMTFTLFYSFMLVKTTHINALSVSWTKIPTLT 240
Cdd:MTH00135 161 TLVGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPALT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 241 ALIPFILLSLGGLPPLTGFLPKWLILQELTKQELAPIAALAALFSLFSLYFYLRLSYSMTLTMLPNNPMGTLPWRLNSTN 320
Cdd:MTH00135 241 ALTPLILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLPSTQ 320

                        330       340
                 ....*....|....*....|....*.
gi 126466588 321 STFPLALTTTVTIIPSPITPALVSFF 346
Cdd:MTH00135 321 LTLPLAISTTATLMLLPLTPAILALL 346
 
Name Accession Description Interval E-value
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-346 1.31e-164

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 463.12  E-value: 1.31e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588   1 MTPIVLSTLIMSLGIGTTLTFTSTHWFLAWMGIEINTLAIIPLMTQDHSPRATEATTKYFFAQATASATLLFAATSNAFF 80
Cdd:MTH00135   1 MNPYVLTILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  81 TGSWDILQYNHPLSSSLLTLALAMKIGLAPLHSWMPEVMQGLNLLTALILSTWQKLAPMCLIYQIQPHNPMLIILLGLLS 160
Cdd:MTH00135  81 TGQWDIQQMSHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPTNPTLLITLGLTS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 161 IIMGGWGGFNQVQLRKILAYSSIAHLGWMVLILPFSSSLTLLAFATYLMMTFTLFYSFMLVKTTHINALSVSWTKIPTLT 240
Cdd:MTH00135 161 TLVGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPALT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 241 ALIPFILLSLGGLPPLTGFLPKWLILQELTKQELAPIAALAALFSLFSLYFYLRLSYSMTLTMLPNNPMGTLPWRLNSTN 320
Cdd:MTH00135 241 ALTPLILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLPSTQ 320

                        330       340
                 ....*....|....*....|....*.
gi 126466588 321 STFPLALTTTVTIIPSPITPALVSFF 346
Cdd:MTH00135 321 LTLPLAISTTATLMLLPLTPAILALL 346
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-267 2.52e-16

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 78.12  E-value: 2.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588   23 STHWFLAWMGIEINTLAIIPLMT-QDHSPRATEATTKYFFAQATASATLLFAATSNAFFTGSWDILQYNHPLSSSLLTLA 101
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGyWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSKALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  102 LAM-----------KIGLAPLHSWMPEVMQGLNLL-TALILSTWQKLAPMCLIYQIQPHNPMLIILLGLLSII------M 163
Cdd:pfam00361  81 LLLlfllilvgflfKSAQVPFHTWLPDAYEGAPTPvSALLAATLVKAGGYGLIRRSLLYLPSSPFIQQILLILaiismlL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  164 GGWGGFNQVQLRKILAYSSIAHLGWMVLIL----PFSSSLTLLAFATYLMMTFTLFYSFMLV-----KTTHINALSVSWT 234
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALgagtIYGIQAAIFHLLTHGLFSAGLFLCAGSViyrrvHTRNIRDYGGLAK 240

                         250       260       270
                  ....*....|....*....|....*....|...
gi 126466588  235 KIPTLTALIPFILLSLGGLPPLTGFLPKWLILQ 267
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILA 273
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 8-299 8.03e-10

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 59.74  E-value: 8.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588   8 TLIMSLGIGTTLTFTSTHWFLAWMGIEINTLAIIPL-MTQDHSPRATEATTKYFFAQATASATLLFAATSNAFFTGSWDI 86
Cdd:COG1007  106 ALLLFATLGMMLMASANDLLTLFLGLELLSLSLYVLvAFRRDDRRSSEAALKYFLLGALSSGFLLYGISLLYGATGSLNL 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  87 LQYNHPLSSSLLTLALAM------------KIGLAPLHSWMPEVMQGLNLLTALILSTWQKLAPMCLIYQI------QPH 148
Cdd:COG1007  186 AGIAAALAAGGANSPLLLlglvlvlaglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLlveafpGLA 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 149 NPMLIILLGLLSIIM--GGWGGFNQVQLRKILAYSSIAHLGWMVLIL----PFSSSLTLLAFATYLMMTFTLFYSFMLVK 222
Cdd:COG1007  266 ADWQLLLAVLAVLSMtvGNLAALAQTNVKRMLAYSSIAHAGYLLLGLaagtPLGVSAALFYLLAYLFMNLGAFAVILLLS 345

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 223 -----TTHINALSVSWTKIPTLTAL----------IPfillslgglpPLTGFLPKWLILQELTKQELAPIAALAALFSLF 287
Cdd:COG1007  346 rkggeAEEIEDLAGLARRSPLLALAmtifllslagIP----------PTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVI 415

                        330
                 ....*....|..
gi 126466588 288 SLYFYLRLSYSM 299
Cdd:COG1007  416 SAYYYLRVVKAM 427
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 23-299 1.42e-08

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 56.11  E-value: 1.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588   23 STHWFLAWMGIEINTLAIIPLMT-QDHSPRATEATTKYFFAQATASATLLFAATSNAFFTGSW---DILQYNHPLSSSLL 98
Cdd:TIGR01770 121 SNDLLSIYLGLELQSLCFYVLAGlKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYGFTGSLnfeDLLLFLSNGMLNIS 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588   99 TLAL---------AMKIGLAPLHSWMPEVMQGLNLLTALILSTWQKLA--------PMCLIYQIQPHNPMLIILLGLLSI 161
Cdd:TIGR01770 201 LLLLgivlilvglLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAifavflrlFLYILFGFSEAWQIFLAIIAFLSM 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  162 IMGGWGGFNQVQLRKILAYSSIAHLGWMVLILPFSSSL----TLLAFATYLMMTFTLFYSFMLVKTT------HINALSV 231
Cdd:TIGR01770 281 LIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEgikaVLFYIFIYALMSLGAFGVLSLLRSYkdewieYISDFAG 360

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 126466588  232 SWTKIPTLTALIPFILLSLGGLPPLTGFLPKWLILQELTKQELAPIAALAALFSLFSLYFYLRLSYSM 299
Cdd:TIGR01770 361 LFKTNPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRVVKVM 428
 
Name Accession Description Interval E-value
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-346 1.31e-164

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 463.12  E-value: 1.31e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588   1 MTPIVLSTLIMSLGIGTTLTFTSTHWFLAWMGIEINTLAIIPLMTQDHSPRATEATTKYFFAQATASATLLFAATSNAFF 80
Cdd:MTH00135   1 MNPYVLTILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  81 TGSWDILQYNHPLSSSLLTLALAMKIGLAPLHSWMPEVMQGLNLLTALILSTWQKLAPMCLIYQIQPHNPMLIILLGLLS 160
Cdd:MTH00135  81 TGQWDIQQMSHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPTNPTLLITLGLTS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 161 IIMGGWGGFNQVQLRKILAYSSIAHLGWMVLILPFSSSLTLLAFATYLMMTFTLFYSFMLVKTTHINALSVSWTKIPTLT 240
Cdd:MTH00135 161 TLVGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPALT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 241 ALIPFILLSLGGLPPLTGFLPKWLILQELTKQELAPIAALAALFSLFSLYFYLRLSYSMTLTMLPNNPMGTLPWRLNSTN 320
Cdd:MTH00135 241 ALTPLILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLPSTQ 320

                        330       340
                 ....*....|....*....|....*.
gi 126466588 321 STFPLALTTTVTIIPSPITPALVSFF 346
Cdd:MTH00135 321 LTLPLAISTTATLMLLPLTPAILALL 346
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 1-346 2.25e-121

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 353.46  E-value: 2.25e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588   1 MTPIVLSTLIMSLGIGTTLTFTSTHWFLAWMGIEINTLAIIPLMTQDHSPRATEATTKYFFAQATASATLLFAATSNAFF 80
Cdd:MTH00070   1 MSPYALSILLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  81 TGSWDILQYNHPLSSSLLTLALAMKIGLAPLHSWMPEVMQGLNLLTALILSTWQKLAPMCLIYQIQPH-NPMLIILLGLL 159
Cdd:MTH00070  81 TGEWTIMNMQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQISHLlNSNLLIIMGLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 160 SIIMGGWGGFNQVQLRKILAYSSIAHLGWMVLILPFSSSLTLLAFATYLMMTFTLFYSFMLVKTTHINALSVSWTKIPTL 239
Cdd:MTH00070 161 STLIGGWGGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNPTL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 240 TALIPFILLSLGGLPPLTGFLPKWLILQELTKQELAPIAALAALFSLFSLYFYLRLSYSMTLTMLPNNPMGTLPWRLNsT 319
Cdd:MTH00070 241 TSMMMLTLLSLGGLPPTTGFIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSYAMSLTTSPNTSNSKLYWRFK-N 319

                        330       340
                 ....*....|....*....|....*..
gi 126466588 320 NSTFPLALTTTVTIIPSPITPALVSFF 346
Cdd:MTH00070 320 KTNNLLSLTIILSLMLLPITPTILNLF 346
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-342 5.48e-106

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 314.07  E-value: 5.48e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588   1 MTPIVLSTLIMSLGIGTTLTFTSTHWFLAWMGIEINTLAIIPLMTQDHSPRATEATTKYFFAQATASATLLFAATSNAFF 80
Cdd:MTH00112   1 MNPHAKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  81 TGSWDILQYNHPLSSSLLTLALAMKIGLAPLHSWMPEVMQGLNLLTALILSTWQKLAPMCLIYQIQPH-NPMLIILLGLL 159
Cdd:MTH00112  81 TGQWDITQLTNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSlNPTLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 160 SIIMGGWGGFNQVQLRKILAYSSIAHLGWMVLILPFSSSLTLLAFATYLMMTFTLFYSFMLVKTTHINALSVSWTKIPTL 239
Cdd:MTH00112 161 STLIGGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 240 TALIPFILLSLGGLPPLTGFLPKWLILQELTKQELAPIAALAALFSLFSLYFYLRLSYSMTLTMLPNNPMGTLPWRLNST 319
Cdd:MTH00112 241 NTTLMLTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYISTITLPPNTTNMMMKWRTKPK 320

                        330       340
                 ....*....|....*....|...
gi 126466588 320 NSTfPLALTTTVTIIPSPITPAL 342
Cdd:MTH00112 321 KNT-LTATLTTLSTLLLPLSPMI 342
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-346 8.41e-103

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 306.00  E-value: 8.41e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588   1 MTPIVLSTLIMSLGIGTTLTFTSTHWFLAWMGIEINTLAIIPLMTQDHSPRATEATTKYFFAQATASATLLFAATSNAFF 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  81 TGSWDILQYNHPLSSSLLTLALAMKIGLAPLHSWMPEVMQGLNLLTALILSTWQKLAPMCLIYQIQPH-NPMLIILLGLL 159
Cdd:MTH00105  81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSiNPNLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 160 SIIMGGWGGFNQVQLRKILAYSSIAHLGWMVLILPFSSSLTLLAFATYLMMTFTLFYSFMLVKTTHINALSVSWTKIPTL 239
Cdd:MTH00105 161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 240 TALIPFILLSLGGLPPLTGFLPKWLILQELTKQELAPIAALAALFSLFSLYFYLRLSYSMTLTMLPNNPMGTLPWRLNST 319
Cdd:MTH00105 241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320

                        330       340
                 ....*....|....*....|....*..
gi 126466588 320 NSTFPLALTTTVTIIPSPITPALVSFF 346
Cdd:MTH00105 321 KPMTLLPTLIILSTMLLPLTPMLSILE 347
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-346 6.34e-90

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 273.38  E-value: 6.34e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588   1 MTPIVLSTLIMSLGIGTTLTFTSTHWFLAWMGIEINTLAIIPLMTQDHSPRATEATTKYFFAQATASATLLFAATSNAFF 80
Cdd:MTH00200   1 MSPLILPLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  81 TGSWDILQYNHPLSSSLLTLALAMKIGLAPLHSWMPEVMQGLNLLTALILSTWQKLAPMCLIYQIQP-HNPMLIILLGLL 159
Cdd:MTH00200  81 SGQWGISEMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIQLAPaLNSNILLLLGLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 160 SIIMGGWGGFNQVQLRKILAYSSIAHLGWMVLILPFSSSLTLLAFATYLMMTFTLFYSFMLVKTTHINALSVSWTKIPTL 239
Cdd:MTH00200 161 SVLVGGWGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPIL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 240 TALIPFILLSLGGLPPLTGFLPKWLILQELTKQELAPIAALAALFSLFSLYFYLRLSYSMTLTMLPNNPMGTLPWRlNST 319
Cdd:MTH00200 241 SMLLGLTLLSLGGLPPLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYLTLLTLSPNQINMMSSWR-TKS 319

                        330       340
                 ....*....|....*....|....*..
gi 126466588 320 NSTFPLALTTTVTIIPSPITPALVSFF 346
Cdd:MTH00200 320 NSNLLVGLLLLLSILGLPLTPQLLFLF 346
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 1-346 1.41e-73

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 231.36  E-value: 1.41e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588   1 MTPIVLSTLIMSLGIGTTLTFTSTHWFLAWMGIEINTLAIIPLMTQDHSPRATEATTKYFFAQATASATLLFAATSNAFF 80
Cdd:MTH00041   1 MNRNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  81 TGSWDILQYNHPLSSSLLTLALAMKIGLAPLHSWMPEVMQGLNLLTALILSTWQKLAPM-CLIYQIQPHNPMLIILLGLL 159
Cdd:MTH00041  81 SGSWSINGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLiLLISISNLLNSNILILCGIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 160 SIIMGGWGGFNQVQLRKILAYSSIAHLGWMVLILPFSSSLTLLAFATYLMMTFTLFYSFMLVKTTHINALSVSWTKIPTL 239
Cdd:MTH00041 161 SVLVGGWGGLNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNPIS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 240 TALIPFILLSLGGLPPLTGFLPKWLILQELTKQELAPIAALAALFSLFSLYFYLRLSYSMTLTMLPNNPMGTLPWRLNST 319
Cdd:MTH00041 241 AFLFILSILSLGGLPPLTGFLNKFISLYCLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLFPQHSISLFSWRNSGN 320

                        330       340
                 ....*....|....*....|....*....
gi 126466588 320 NSTFPLALT--TTVTIIPSPITPALVSFF 346
Cdd:MTH00041 321 ITVYGVILSilSSISILGLLLIPLFLSFL 349
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 10-307 2.30e-48

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 165.77  E-value: 2.30e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  10 IMSLGIGTTLTFTSTHWFLAWMGIEINTLAIIPLMTQDHSPRATEATTKYFFAQATASATLLFAATSNAFFTGSWDILqy 89
Cdd:MTH00160  11 LSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNLMLFNNI-- 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  90 nhplSSSLLTLALAMKIGLAPLHSWMPEVMQGLNLLTALILSTWQKLAPMCLIYQIQphNPMLIILLGLLSIIMGGWGGF 169
Cdd:MTH00160  89 ----SSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLI--NNNFIIIIIILSAIIGAIGGL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 170 NQVQLRKILAYSSIAHLGWMVLILPFSSSLTLLAFATYLMMTFTLFYSFMLVKTTHINALSVSWTKIPTLTALIPFILLS 249
Cdd:MTH00160 163 NQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLLFLNLLS 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 126466588 250 LGGLPPLTGFLPKWLILQELTKQELAPIAALAALFSLFSLYFYLRLSYSMTLTMLPNN 307
Cdd:MTH00160 243 LGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKN 300
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 10-303 3.44e-42

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 149.27  E-value: 3.44e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  10 IMSLGIGTTLTFTSTHWFLAWMGIEINTLAIIPLMTQDHSPRATEATTKYFFAQATASATLLFAATSNAFFTGSWDILqy 89
Cdd:MTH00144  10 LFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFSWFSM-- 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  90 nhplssSLLTLALAMKIGLAPLHSWMPEVMQGLNLLTALILSTWQKLAPMCLIYQIQPHNPMLIILLGLLSIIM--GGWG 167
Cdd:MTH00144  88 ------SLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLAYLLCVISVLSAlvGSIG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 168 GFNQVQLRKILAYSSIAHLGWMVLILPFSSSLTLLAFATYLMMTFTLFYSFMLVKTTHINALSVSWTKIPTLTALIPFIl 247
Cdd:MTH00144 162 GLNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSLKPSYKTGLSIISLL- 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 126466588 248 LSLGGLPPLTGFLPKWLILQELTKQELAPIAALAALFSLFSLYFYLRLSYSMTLTM 303
Cdd:MTH00144 241 LSLGGLPPFLGFCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSS 296
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 7-303 6.89e-39

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 140.69  E-value: 6.89e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588   7 STLIMslgiGTTLTFTSTHWFLAWMGIEINTLAIIPLMTQDHSPRATEATTKYFFAQATASATLLFAATSNAFFTGSWDI 86
Cdd:MTH00011  13 STMTL----GTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMMWSFPSLLKN 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  87 lqynhpLSSSLLTLALAMKIGLAPLHSWMPEVMQGLNLLTALILSTWQKLAPMCLIYQIQPHNPMLIILLGLLSIIM-GG 165
Cdd:MTH00011  89 ------ITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNILPMMTSMAAMSALaGG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 166 WGGFNQVQLRKILAYSSIAHLGWMVLILPFSSSLTLLAFATYLMMTFTLFYSFMLVKTTHINALSVSWTKIPTLTALIPF 245
Cdd:MTH00011 163 LGGMNQTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQTTSMSLFI 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 126466588 246 ILLSLGGLPPLTGFLPKWLILQELTKQELAPIAALAALFSLFSLYFYLRLSYSMTLTM 303
Cdd:MTH00011 243 MLLSLGGLPPFTGFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIFNFMYLS 300
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 15-339 2.45e-33

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 125.55  E-value: 2.45e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  15 IGTTLTFTSTHWFLAWMGIEINTLAIIPLMTQDHSPRATEATTKYFFAQATASATLLFAATSNAFFTgswdilqYNHPLS 94
Cdd:MTH00197   9 GGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSFSNL-------YLSLLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  95 SSLLTLALAMKIGLAPLHSWMPEVMQGLNLLTALILSTWQKLAPMCLIYQIQpHNPMLIILLGLLSIIMGGWGGFNQVQL 174
Cdd:MTH00197  82 VVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNS-SSFMGLLICSVLSSLIGGIGGMNQSNI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 175 RKILAYSSIAHLGWMVLILPFSSSLTLLAFATYLMMTFTLFYSFMLVKTTHINALSVSWTKIPTLTALIPFILLSLGGLP 254
Cdd:MTH00197 161 RQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFLGLSFLSLGGLP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 255 PLTGFLPKWLILQELTKQELAPIAALAALFSLFSLYFYLRLSYSmtlTMLPNNPMGTLPWRLNSTNSTFPLALTTTVTII 334
Cdd:MTH00197 241 PLSGFFLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAYK---SLILSNWMINFLMKINLLYSGLFILLMMMLPLL 317


                 ....*
gi 126466588 335 PSPIT 339
Cdd:MTH00197 318 MIFTM 322
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-267 2.52e-16

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 78.12  E-value: 2.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588   23 STHWFLAWMGIEINTLAIIPLMT-QDHSPRATEATTKYFFAQATASATLLFAATSNAFFTGSWDILQYNHPLSSSLLTLA 101
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGyWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSKALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  102 LAM-----------KIGLAPLHSWMPEVMQGLNLL-TALILSTWQKLAPMCLIYQIQPHNPMLIILLGLLSII------M 163
Cdd:pfam00361  81 LLLlfllilvgflfKSAQVPFHTWLPDAYEGAPTPvSALLAATLVKAGGYGLIRRSLLYLPSSPFIQQILLILaiismlL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  164 GGWGGFNQVQLRKILAYSSIAHLGWMVLIL----PFSSSLTLLAFATYLMMTFTLFYSFMLV-----KTTHINALSVSWT 234
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALgagtIYGIQAAIFHLLTHGLFSAGLFLCAGSViyrrvHTRNIRDYGGLAK 240

                         250       260       270
                  ....*....|....*....|....*....|...
gi 126466588  235 KIPTLTALIPFILLSLGGLPPLTGFLPKWLILQ 267
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILA 273
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 15-295 1.33e-13

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 70.83  E-value: 1.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  15 IGTTLTFTSTHWFLAWMGIEINTLAIIPLMTQDH-SPRATEATTKYFFAQATASATLLFAATSNAFFTGSWDILQYN--- 90
Cdd:MTH00196   4 LGILCLISSSNWLSVYLAIELQTLSLFILIAQNRgSGYSAEAGLKYFVLGALSSGLFLFGCALLCGTTGGLHLSYINlvl 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  91 ----------HPLSSSLLTLALAMKIGLAPLHSWMPEVMQGLNLLTALILSTWQKLAPMCLIYQIQPhNPMLIILLGLLS 160
Cdd:MTH00196  84 nsgqsfssvsVPIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGL-NVNILLIGGLFS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 161 IIMGGWGGFNQVQLRKILAYSSIAHLGWMVLILPFSSSLTLLAFATYL---MMTFTLFYSFMLVKTTHINAL---SVSWT 234
Cdd:MTH00196 163 LFVGAIGALNQTKIKRLLAYSGIGHMGFVLWGIEIGSFESIQASLVYLfiyIIMSICVFSIILALNVYKNLIiefSGLSR 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126466588 235 KIPTLTALIPFILLSLGGLPPLTGFLPKWLILQELTKQELAPIAALAALFSLFSLYFYLRL 295
Cdd:MTH00196 243 RLPILAITLALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRI 303
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 9-266 1.11e-11

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 65.42  E-value: 1.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588   9 LIMSLGIGTTLTFTSTHWFLAWMGIEINTLAI-IPLMTQDHSPRATEATTKYFFAQATASATLLFAATSNAFFTGSWDIL 87
Cdd:MTH00199 102 LILIVALGSLLLVSSINWLSIYLAIELQTLTLfILVALKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALLYGLTGETSIQ 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  88 QYNHPLSS----SLLTLALAMKIGLAPLHSWMPEVMQGLNLLTALILSTWQKLAPMCLIYQIQPHNPMLIILLGLLSIIm 163
Cdd:MTH00199 182 GINSILTGdvgkILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTNVVLICAVLSIIY- 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 164 GGWGGFNQVQLRKILAYSSIAHLG---WMVLILPFSS-SLTLLAFATYLMMT---FTLFYSFMLVKTTHINALSVSwTKI 236
Cdd:MTH00199 261 GAIGALNQTKIKRLLAYSGIGHMGfilFGVAIGSFESiQASLIYMIIYVIMSicsFSIILSLKLTKGLIVEVSGLS-RKN 339

                        250       260       270
                 ....*....|....*....|....*....|
gi 126466588 237 PTLTALIPFILLSLGGLPPLTGFLPKWLIL 266
Cdd:MTH00199 340 PVIALTLALTFLSIAGIPPLAGFLSKWLIL 369
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
23-338 2.49e-10

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 61.38  E-value: 2.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  23 STHWFLAWMGIEINTLAIIPL-MTQDHSPRATEATTKYFFAQATASATLLFAATSNAFFTGSWDILQYNHPLSSSLLTLA 101
Cdd:PRK05777 122 ANDLLTLFLGLELLSLPLYALaALRRDRRRSLEAAIKYFVLGALASGFLLYGMSLLYGATGSLSFAGIAKALADGSGNSL 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 102 LAM------------KIGLAPLHSWMPEVMQGLNLLTALILSTWQKLAPMCLIYQI------QPHNPMLIILLGLLSIIM 163
Cdd:PRK05777 202 LLLfglvfllvglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLLRLlvvafgGLSEDWQQVLAIIAIASM 281

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 164 --GGWGGFNQVQLRKILAYSSIAHLGWMVLIL----PFSSSLTLLAFATYLMMTFTLFYSFMLVK-----TTHINALS-V 231
Cdd:PRK05777 282 lvGNLAALSQTNIKRLLAYSSIAHAGYLLVGLaagtAEGYSAVLFYLLAYLFMTLGAFGVISLLRrkggeAESISDFAgL 361

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 232 SWTKiPTLTALIPFILLSLGGLPPLTGFLPKWLILQELTKQELAPIAALAALFSLFSLYFYLRLSYSMTLTMLPNNPMGT 311
Cdd:PRK05777 362 SKRS-PLLAAVMTIFMLSLAGIPPTAGFWGKFYVFEAAVEAGLWWLAVIGVLNSAIGAFYYLRVIKLMYFDEPPRDAPVN 440

                        330       340
                 ....*....|....*....|....*..
gi 126466588 312 LPWRLNSTNSTFPLALTTTVTIIPSPI 338
Cdd:PRK05777 441 WPLSAGGAVLSVSALLVLVLGIFPQPL 467
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 8-299 8.03e-10

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 59.74  E-value: 8.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588   8 TLIMSLGIGTTLTFTSTHWFLAWMGIEINTLAIIPL-MTQDHSPRATEATTKYFFAQATASATLLFAATSNAFFTGSWDI 86
Cdd:COG1007  106 ALLLFATLGMMLMASANDLLTLFLGLELLSLSLYVLvAFRRDDRRSSEAALKYFLLGALSSGFLLYGISLLYGATGSLNL 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  87 LQYNHPLSSSLLTLALAM------------KIGLAPLHSWMPEVMQGLNLLTALILSTWQKLAPMCLIYQI------QPH 148
Cdd:COG1007  186 AGIAAALAAGGANSPLLLlglvlvlaglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLlveafpGLA 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 149 NPMLIILLGLLSIIM--GGWGGFNQVQLRKILAYSSIAHLGWMVLIL----PFSSSLTLLAFATYLMMTFTLFYSFMLVK 222
Cdd:COG1007  266 ADWQLLLAVLAVLSMtvGNLAALAQTNVKRMLAYSSIAHAGYLLLGLaagtPLGVSAALFYLLAYLFMNLGAFAVILLLS 345

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 223 -----TTHINALSVSWTKIPTLTAL----------IPfillslgglpPLTGFLPKWLILQELTKQELAPIAALAALFSLF 287
Cdd:COG1007  346 rkggeAEEIEDLAGLARRSPLLALAmtifllslagIP----------PTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVI 415

                        330
                 ....*....|..
gi 126466588 288 SLYFYLRLSYSM 299
Cdd:COG1007  416 SAYYYLRVVKAM 427
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 23-299 1.42e-08

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 56.11  E-value: 1.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588   23 STHWFLAWMGIEINTLAIIPLMT-QDHSPRATEATTKYFFAQATASATLLFAATSNAFFTGSW---DILQYNHPLSSSLL 98
Cdd:TIGR01770 121 SNDLLSIYLGLELQSLCFYVLAGlKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYGFTGSLnfeDLLLFLSNGMLNIS 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588   99 TLAL---------AMKIGLAPLHSWMPEVMQGLNLLTALILSTWQKLA--------PMCLIYQIQPHNPMLIILLGLLSI 161
Cdd:TIGR01770 201 LLLLgivlilvglLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAifavflrlFLYILFGFSEAWQIFLAIIAFLSM 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  162 IMGGWGGFNQVQLRKILAYSSIAHLGWMVLILPFSSSL----TLLAFATYLMMTFTLFYSFMLVKTT------HINALSV 231
Cdd:TIGR01770 281 LIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEgikaVLFYIFIYALMSLGAFGVLSLLRSYkdewieYISDFAG 360

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 126466588  232 SWTKIPTLTALIPFILLSLGGLPPLTGFLPKWLILQELTKQELAPIAALAALFSLFSLYFYLRLSYSM 299
Cdd:TIGR01770 361 LFKTNPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRVVKVM 428
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 8-299 2.99e-08

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 54.77  E-value: 2.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588   8 TLIMSLGIGTTLTFTSTHWFLAWMGIEINTLAIIPLMTQDHSPRATEATTKYFFAQATASATLLFAATSNAFFTGSWDI- 86
Cdd:COG0651  111 PLFLLLLAGMNGAFLTGDLFNLFVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGATGTLNMa 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  87 -LQYNHPLSSSLLTLALA--------MKIGLAPLHSWMPE-----------VMQGLNLLTAL--ILSTWQklapmcLIYQ 144
Cdd:COG0651  191 dLAARLAELDPGLLLAAFalllvgfgIKAALFPLHFWLPDaypaapspvsaLLSGLLTKVGVyaILRVLT------LLFG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 145 IQPHNPMLIILLGLLSIIM--GGWGGFNQVQLRKILAYSSIAHLGWMVLILPFSSSLTLLAFATYL----MMTFTLFYSF 218
Cdd:COG0651  265 ADPALFLGTLLLVLGLLTMlvGALGALAQRDLKRLLAYSSVSQIGYILLGLGLGTPLGLAGALFHLlnhaLAKALLFLAA 344

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 219 MLV----KTTHINALSVSWTKIPTLTALI-----------PFIllslgglppltGFLPKWLILQELTKQELAPIAALAAL 283
Cdd:COG0651  345 GAIeratGTRDLDKLGGLGKRMPLTAAAFligalalaglpPLS-----------GFVSKWLLLQAALEAGAWLLAAVLLL 413

                        330
                 ....*....|....*.
gi 126466588 284 FSLFSLYFYLRLSYSM 299
Cdd:COG0651  414 SSLLTLAYFVRIFGRA 429
NADH_dehy_S2_C pfam06444
NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region ...
 290-340 6.20e-08

NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with pfam00361.


Pssm-ID: 461914 [Multi-domain]  Cd Length: 51  Bit Score: 48.41  E-value: 6.20e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 126466588  290 YFYLRLSYSMTLTMLPNNPMGTLPWRLNSTNSTFPLALTTTVTIIPSPITP 340
Cdd:pfam06444   1 FFYLRLSYSTTLTLFPNTNNSKMKWRFNSTKNTLLLPTLTTLSILLLPLTP 51
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 9-223 8.17e-06

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 47.55  E-value: 8.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588   9 LIMSLGIGTTLTFTSTHWFLAWMGIEINTLAIIPLMTQDHSPRAT---------EATTKYFFAQATASATLLFAATSNAF 79
Cdd:MTH00198 193 LVLIVGLGGLLLIESANWLTIYLALEFQTLALFILAGEGSQPGSHfpspgntppESGLKYWILGAMSSGFYLFGCALYFG 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588  80 FTGS--------------WDILQYNHPLSSSLLTLALAMKIGLAPLHSWMPEVMQGLNLLTALILSTWQKLAPMCLIYQI 145
Cdd:MTH00198 273 FTGNegmlgtilsatletTNIELRQGSLGYLFITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILLTSL 352

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 126466588 146 QPHNPMLIILLGLLSIiMGGWGGFNQVQLRKILAYSSIAHLGWMVLILPFSSSLTLLAFATYLMMTF-TLFYSFMLVKT 223
Cdd:MTH00198 353 VITSKLLLSVAIISLV-VGAFGALNQTRIKRLLAYSGIGHIGFILIGVSAGTYESLQASWTYAVTYLvSALASFTVICT 430
PRK07376 PRK07376
NADH-quinone oxidoreductase subunit L;
110-191 7.66e-03

NADH-quinone oxidoreductase subunit L;


Pssm-ID: 236005 [Multi-domain]  Cd Length: 673  Bit Score: 38.08  E-value: 7.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126466588 110 PLHSWMPEVMQGLNLLTALILSTWQKLAPMCLIYQIQP---HNPMLIILLG---LLSIIMGGWGGFNQVQLRKILAYSSI 183
Cdd:PRK07376 245 PLHVWLPDAMEGPTPISALIHAATMVAAGVFLVARMYPvfeQFPAVMTVIAwtgAITAFLGASIALTQNDIKKGLAYSTI 324


                 ....*...
gi 126466588 184 AHLGWMVL 191
Cdd:PRK07376 325 SQLGYMVM 332
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
 171-224 8.33e-03

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 37.72  E-value: 8.33e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 126466588 171 QVQLRKILAYSSIAHLGWMVLILpFSSSLTLLAFATYLMMTFTLFYSFMLVKTT 224
Cdd:MTH00217 293 QVDLKRIIAYSSVAHMGLVTLGI-FSHTIQGLVAAIFLMLAHGLVSSALFIAVT 345
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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