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Conserved domains on  [gi|126302531|sp|O15335|]
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RecName: Full=Chondroadherin; AltName: Full=Cartilage leucine-rich protein; Flags: Precursor

Protein Classification

LRR and LRRCT domain-containing protein( domain architecture ID 12020582)

protein containing domains LRRNT, LRR, and LRRCT

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-301 3.75e-26

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.10  E-value: 3.75e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531  50 SEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQirevaagAFRGLKQLIYLYLSHNDIRVLrAGAFDDLTELTYLY 129
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELD 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 130 LDHNKVTELPRGLlSPLVNLFILQLNNNKIRELRAgAFQGAKDLRWLYLSENALSSLqPGALDDVENLAKFHVDRNQLSS 209
Cdd:COG4886  143 LSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTD 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 210 YPsAALSKLRVVEELKLSHNPLKSIPDnafqsfgryletlwldntnlekfsdgaFLGVTTLKHVHLENNRLNQLPSNFPF 289
Cdd:COG4886  220 LP-EPLANLTNLETLDLSNNQLTDLPE---------------------------LGNLTNLEELDLSNNQLTDLPPLANL 271

                        250
                 ....*....|..
gi 126302531 290 DSLETLALTNNP 301
Cdd:COG4886  272 TNLKTLDLSNNQ 283
LRRCT smart00082
Leucine rich repeat C-terminal domain;
300-347 5.77e-10

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 54.36  E-value: 5.77e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 126302531   300 NPWKCTCQLRGLRRWLEAK---ASRPDATCASPAKFKGQHIRDTDAFRSCK 347
Cdd:smart00082   1 NPFICDCELRWLLRWLQANehlQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 23-49 3.62e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.30  E-value: 3.62e-05
                          10        20
                  ....*....|....*....|....*..
gi 126302531   23 CPQNCHCHsdLQHVICDKVGLQKIPKV 49
Cdd:pfam01462   2 CPVPCHCS--ATVVNCSDRGLTAVPRD 26
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-301 3.75e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.10  E-value: 3.75e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531  50 SEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQirevaagAFRGLKQLIYLYLSHNDIRVLrAGAFDDLTELTYLY 129
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELD 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 130 LDHNKVTELPRGLlSPLVNLFILQLNNNKIRELRAgAFQGAKDLRWLYLSENALSSLqPGALDDVENLAKFHVDRNQLSS 209
Cdd:COG4886  143 LSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTD 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 210 YPsAALSKLRVVEELKLSHNPLKSIPDnafqsfgryletlwldntnlekfsdgaFLGVTTLKHVHLENNRLNQLPSNFPF 289
Cdd:COG4886  220 LP-EPLANLTNLETLDLSNNQLTDLPE---------------------------LGNLTNLEELDLSNNQLTDLPPLANL 271

                        250
                 ....*....|..
gi 126302531 290 DSLETLALTNNP 301
Cdd:COG4886  272 TNLKTLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
75-135 2.53e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.78  E-value: 2.53e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126302531   75 PNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKV 135
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 35-235 4.10e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.81  E-value: 4.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531  35 HVICDKVGLQKIPKVSEKTKL--LNLQRNNFPVLaaNSFRAMPNLVSLHLQHCQIREVaaGAFRGLKQLIYLYLSHNDIR 112
Cdd:cd21340    6 HLYLNDKNITKIDNLSLCKNLkvLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 113 VLraGAFDDLTELTYLYLDH------NKVTELPRGLLSPLVNLFILQLNNNKIRELRagAFQGAKDLRWLYLSENALSSl 186
Cdd:cd21340   82 VV--EGLENLTNLEELHIENqrlppgEKLTFDPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISD- 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 126302531 187 qpgaLDDVENLakfhvdrnqlssypsaaLSKLRVVEELKLSHNPLKSIP 235
Cdd:cd21340  157 ----LEELLDL-----------------LSSWPSLRELDLTGNPVCKKP 184
LRRCT smart00082
Leucine rich repeat C-terminal domain;
300-347 5.77e-10

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 54.36  E-value: 5.77e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 126302531   300 NPWKCTCQLRGLRRWLEAK---ASRPDATCASPAKFKGQHIRDTDAFRSCK 347
Cdd:smart00082   1 NPFICDCELRWLLRWLQANehlQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
36-237 9.77e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.93  E-value: 9.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531  36 VICDKVGLQKIPK-VSEKTKLLNLQRNNFPVLAANsfraMPNLVS-LHLQHCQIREVAAGAFRGLKQLIylyLSHNDIRV 113
Cdd:PRK15370 204 LILDNNELKSLPEnLQGNIKTLYANSNQLTSIPAT----LPDTIQeMELSINRITELPERLPSALQSLD---LFHNKISC 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 114 LRagafDDLTE-LTYLYLDHNKVTELPRGLLSPLVNLFILqlnNNKIRELRAGAFQGakdLRWLYLSENALSSLQPGALD 192
Cdd:PRK15370 277 LP----ENLPEeLRYLSVYDNSIRTLPAHLPSGITHLNVQ---SNSLTALPETLPPG---LKTLEAGENALTSLPASLPP 346

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 126302531 193 DVENLAkfhVDRNQLSSYPSAALSKLrvvEELKLSHNPLKSIPDN 237
Cdd:PRK15370 347 ELQVLD---VSKNQITVLPETLPPTI---TTLDVSRNALTNLPEN 385
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 23-49 3.62e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.30  E-value: 3.62e-05
                          10        20
                  ....*....|....*....|....*..
gi 126302531   23 CPQNCHCHsdLQHVICDKVGLQKIPKV 49
Cdd:pfam01462   2 CPVPCHCS--ATVVNCSDRGLTAVPRD 26
LRRNT smart00013
Leucine rich repeat N-terminal domain;
23-49 1.57e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.45  E-value: 1.57e-04
                           10        20
                   ....*....|....*....|....*..
gi 126302531    23 CPQNCHCHsdLQHVICDKVGLQKIPKV 49
Cdd:smart00013   2 CPAPCNCS--GTAVDCSGRGLTEVPLD 26
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 291-335 5.64e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 41.99  E-value: 5.64e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 126302531   291 SLETLALTNNPWKCTCQLRGLRRWLE---AKASRPDAT-CASPAKFKGQ 335
Cdd:TIGR00864   20 NLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAAlCAGPGALAGQ 68
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-301 3.75e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.10  E-value: 3.75e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531  50 SEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQirevaagAFRGLKQLIYLYLSHNDIRVLrAGAFDDLTELTYLY 129
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELD 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 130 LDHNKVTELPRGLlSPLVNLFILQLNNNKIRELRAgAFQGAKDLRWLYLSENALSSLqPGALDDVENLAKFHVDRNQLSS 209
Cdd:COG4886  143 LSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTD 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 210 YPsAALSKLRVVEELKLSHNPLKSIPDnafqsfgryletlwldntnlekfsdgaFLGVTTLKHVHLENNRLNQLPSNFPF 289
Cdd:COG4886  220 LP-EPLANLTNLETLDLSNNQLTDLPE---------------------------LGNLTNLEELDLSNNQLTDLPPLANL 271

                        250
                 ....*....|..
gi 126302531 290 DSLETLALTNNP 301
Cdd:COG4886  272 TNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-295 5.10e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 5.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531  33 LQHVICDKVGLQKIPKV-SEKTKL--LNLQRNNFPVLAAnSFRAMPNLVSLHLQHCQIREVAAgAFRGLKQLIYLYLSHN 109
Cdd:COG4886  138 LKELDLSNNQLTDLPEPlGNLTNLksLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGN 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 110 DIRVLrAGAFDDLTELTYLYLDHNKVTELPRglLSPLVNLFILQLNNNKIRELRAGAfqGAKDLRWLYLSENALSSLQPG 189
Cdd:COG4886  216 QLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLK 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 190 ALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTT 269
Cdd:COG4886  291 ELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLG 370

                        250       260
                 ....*....|....*....|....*.
gi 126302531 270 LKHVHLENNRLNQLPSNFPFDSLETL 295
Cdd:COG4886  371 LLGLLEATLLTLALLLLTLLLLLLTT 396
LRR_8 pfam13855
Leucine rich repeat;
75-135 2.53e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.78  E-value: 2.53e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126302531   75 PNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKV 135
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 35-235 4.10e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.81  E-value: 4.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531  35 HVICDKVGLQKIPKVSEKTKL--LNLQRNNFPVLaaNSFRAMPNLVSLHLQHCQIREVaaGAFRGLKQLIYLYLSHNDIR 112
Cdd:cd21340    6 HLYLNDKNITKIDNLSLCKNLkvLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 113 VLraGAFDDLTELTYLYLDH------NKVTELPRGLLSPLVNLFILQLNNNKIRELRagAFQGAKDLRWLYLSENALSSl 186
Cdd:cd21340   82 VV--EGLENLTNLEELHIENqrlppgEKLTFDPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISD- 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 126302531 187 qpgaLDDVENLakfhvdrnqlssypsaaLSKLRVVEELKLSHNPLKSIP 235
Cdd:cd21340  157 ----LEELLDL-----------------LSSWPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 80-249 2.40e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 2.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531  80 LHLQHCQIREVaaGAFRGLKQLIYLYLSHNDIRVLRAgaFDDLTELTYLYLDHNKVTELPRglLSPLVNLFILQLNNNKI 159
Cdd:cd21340    7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 160 RELraGAFQGAKDLRWLYLSENALSS-----LQPGALDDV-ENLAKFHVDRNQLSSYpsAALSKLRVVEELKLSHNPLKS 233
Cdd:cd21340   81 SVV--EGLENLTNLEELHIENQRLPPgekltFDPRSLAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISD 156

                        170
                 ....*....|....*...
gi 126302531 234 IPD--NAFQSFgRYLETL 249
Cdd:cd21340  157 LEEllDLLSSW-PSLREL 173
LRRCT smart00082
Leucine rich repeat C-terminal domain;
300-347 5.77e-10

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 54.36  E-value: 5.77e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 126302531   300 NPWKCTCQLRGLRRWLEAK---ASRPDATCASPAKFKGQHIRDTDAFRSCK 347
Cdd:smart00082   1 NPFICDCELRWLLRWLQANehlQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
123-183 1.78e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 1.78e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126302531  123 TELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENAL 183
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
148-207 1.97e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 1.97e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531  148 NLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQL 207
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
100-159 2.83e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 2.83e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531  100 QLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKI 159
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
56-111 4.00e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 4.00e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 126302531   56 LNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDI 111
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
36-237 9.77e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.93  E-value: 9.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531  36 VICDKVGLQKIPK-VSEKTKLLNLQRNNFPVLAANsfraMPNLVS-LHLQHCQIREVAAGAFRGLKQLIylyLSHNDIRV 113
Cdd:PRK15370 204 LILDNNELKSLPEnLQGNIKTLYANSNQLTSIPAT----LPDTIQeMELSINRITELPERLPSALQSLD---LFHNKISC 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 114 LRagafDDLTE-LTYLYLDHNKVTELPRGLLSPLVNLFILqlnNNKIRELRAGAFQGakdLRWLYLSENALSSLQPGALD 192
Cdd:PRK15370 277 LP----ENLPEeLRYLSVYDNSIRTLPAHLPSGITHLNVQ---SNSLTALPETLPPG---LKTLEAGENALTSLPASLPP 346

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 126302531 193 DVENLAkfhVDRNQLSSYPSAALSKLrvvEELKLSHNPLKSIPDN 237
Cdd:PRK15370 347 ELQVLD---VSKNQITVLPETLPPTI---TTLDVSRNALTNLPEN 385
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
142-301 1.13e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 1.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 142 LLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHvdrnQLSSYPSAALSKLRVV 221
Cdd:COG4886   40 LSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT----ELDLSGNEELSNLTNL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 222 EELKLSHNPLKSIPDNAFQSfgRYLETLWLDNTNLEKFSDgAFLGVTTLKHVHLENNRLNQLPSNF-PFDSLETLALTNN 300
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANL--TNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELgNLTNLKELDLSNN 192


                 .
gi 126302531 301 P 301
Cdd:COG4886  193 Q 193
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 122-300 8.15e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 8.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 122 LTELTYLYLDHNKVTELprGLLSPLVNLFILQLNNNKIRELRAgaFQGAKDLRWLYLSENALSSLQPgaLDDVENLAKFH 201
Cdd:cd21340    1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 202 VDRNQLSsypsaalsklrVVEELKLSHNplksipdnafqsfgryLETLWLDNTNLEK-----FSDGAFLGV-TTLKHVHL 275
Cdd:cd21340   75 LGGNRIS-----------VVEGLENLTN----------------LEELHIENQRLPPgekltFDPRSLAALsNSLRVLNI 127

                        170       180
                 ....*....|....*....|....*
gi 126302531 276 ENNRLNQLPSNFPFDSLETLALTNN 300
Cdd:cd21340  128 SGNNIDSLEPLAPLRNLEQLDASNN 152
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 121-267 1.91e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 1.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 121 DLTELTYLYLDHNKVT-ELPRGLLSPlvNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENLAK 199
Cdd:PLN00113 450 DMPSLQMLSLARNKFFgGLPDSFGSK--RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVS 527

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 126302531 200 FHVDRNQLSSYPSAALSKLRVVEELKLSHNPLK-SIPDNafqsFGRyLETLWLDNTNLEKF-----SDGAFLGV 267
Cdd:PLN00113 528 LDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKN----LGN-VESLVQVNISHNHLhgslpSTGAFLAI 596
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
39-288 1.33e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.00  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531  39 DKVGLQKIPK-VSEKTKLLNLQRNNFPVLAANsframpnlvslhlQHCQIREvaagafrglkqliyLYLSHNDIRVLRAG 117
Cdd:PRK15370 186 KILGLTTIPAcIPEQITTLILDNNELKSLPEN-------------LQGNIKT--------------LYANSNQLTSIPAT 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 118 AFDDLTELTylyLDHNKVTELPRGLLSPLVNLfilQLNNNKIRELRAGAFQGakdLRWLYLSENALSSLqPGALDdvENL 197
Cdd:PRK15370 239 LPDTIQEME---LSINRITELPERLPSALQSL---DLFHNKISCLPENLPEE---LRYLSVYDNSIRTL-PAHLP--SGI 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 198 AKFHVDRNQLSSYPSAALSKLRVVEElklSHNPLKSIPdnafQSFGRYLETLWLDNTNLEKFSDGAflgVTTLKHVHLEN 277
Cdd:PRK15370 307 THLNVQSNSLTALPETLPPGLKTLEA---GENALTSLP----ASLPPELQVLDVSKNQITVLPETL---PPTITTLDVSR 376

                        250
                 ....*....|.
gi 126302531 278 NRLNQLPSNFP 288
Cdd:PRK15370 377 NALTNLPENLP 387
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 90-282 1.91e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.81  E-value: 1.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531  90 VAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLT---ELTYLYLDHNKVTELP-----RGLLSPLVNLFILQLNNNKI-- 159
Cdd:cd00116   72 SLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLrssSLQELKLNNNGLGDRGlrllaKGLKDLPPALEKLVLGRNRLeg 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 160 ---RELrAGAFQGAKDLRWLYLSENALssLQPG------ALDDVENLAKFHVDRNQL----SSYPSAALSKLRVVEELKL 226
Cdd:cd00116  152 ascEAL-AKALRANRDLKELNLANNGI--GDAGiralaeGLKANCNLEVLDLNNNGLtdegASALAETLASLKSLEVLNL 228

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 126302531 227 SHNPLKSIP----DNAFQSFGRYLETLWLDNTNLEKFSDGAFLGV----TTLKHVHLENNRLNQ 282
Cdd:cd00116  229 GDNNLTDAGaaalASALLSPNISLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKFGE 292
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 23-49 3.62e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.30  E-value: 3.62e-05
                          10        20
                  ....*....|....*....|....*..
gi 126302531   23 CPQNCHCHsdLQHVICDKVGLQKIPKV 49
Cdd:pfam01462   2 CPVPCHCS--ATVVNCSDRGLTAVPRD 26
LRR_8 pfam13855
Leucine rich repeat;
221-280 5.59e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 5.59e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531  221 VEELKLSHNPLKSIPDNAFQSFgRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRL 280
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGL-SNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-212 7.57e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 7.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531  50 SEKTKL-----LNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGlKQLIYLYLSHNDIRVLRAGAFDDLTE 124
Cdd:PLN00113 422 SEFTKLplvyfLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSE 500

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 125 LTYLYLDHNKVT-ELPRGlLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHVD 203
Cdd:PLN00113 501 LMQLKLSENKLSgEIPDE-LSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNIS 579

                        170
                 ....*....|
gi 126302531 204 RNQL-SSYPS 212
Cdd:PLN00113 580 HNHLhGSLPS 589
LRRNT smart00013
Leucine rich repeat N-terminal domain;
23-49 1.57e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.45  E-value: 1.57e-04
                           10        20
                   ....*....|....*....|....*..
gi 126302531    23 CPQNCHCHsdLQHVICDKVGLQKIPKV 49
Cdd:smart00013   2 CPAPCNCS--GTAVDCSGRGLTEVPLD 26
LRR_8 pfam13855
Leucine rich repeat;
244-301 2.94e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 2.94e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531  244 RYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSN--FPFDSLETLALTNNP 301
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
196-256 4.67e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 4.67e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126302531  196 NLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRyLETLWLDNTNL 256
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPS-LRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 291-335 5.64e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 41.99  E-value: 5.64e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 126302531   291 SLETLALTNNPWKCTCQLRGLRRWLE---AKASRPDAT-CASPAKFKGQ 335
Cdd:TIGR00864   20 NLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAAlCAGPGALAGQ 68
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 68-256 1.03e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.93  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531  68 ANSFRAMPNLVSLHLQHCQIREVAAGAF----RGLKQLIYLYLSHNDIR----VLRAGAFDDLTELTYLYLDHNKVTELP 139
Cdd:COG5238  201 AEALTQNTTVTTLWLKRNPIGDEGAEILaealKGNKSLTTLDLSNNQIGdegvIALAEALKNNTTVETLYLSGNQIGAEG 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 140 RGLLSPLV----NLFILQLNNNKIRELRAGAF----QGAKDLRWLYLSENALSSlqpgalDDVENLAKfhvdrnqlssyp 211
Cdd:COG5238  281 AIALAKALqgntTLTSLDLSVNRIGDEGAIALaeglQGNKTLHTLNLAYNGIGA------QGAIALAK------------ 342

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 126302531 212 saALSKLRVVEELKLSHNPLKsipDNAFQSFGRYLETlwldNTNL 256
Cdd:COG5238  343 --ALQENTTLHSLDLSDNQIG---DEGAIALAKYLEG----NTTL 378
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 56-300 4.56e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.06  E-value: 4.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531  56 LNLQRNNFPVLAANSFRAMPNLVSLHLQ----HCQIREVAAGafrgLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLD 131
Cdd:PLN00113 265 LFLYQNKLSGPIPPSIFSLQKLISLDLSdnslSGEIPELVIQ----LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLW 340

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 132 HNKVT-ELPRGLlSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSY 210
Cdd:PLN00113 341 SNKFSgEIPKNL-GKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGE 419

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302531 211 PSAALSKLRVVEELKLSHNPLKsipdnafqsfGRYLETLWlDNTNLEKFSDGaflgvttlkhvhlENNRLNQLPSNFPFD 290
Cdd:PLN00113 420 LPSEFTKLPLVYFLDISNNNLQ----------GRINSRKW-DMPSLQMLSLA-------------RNKFFGGLPDSFGSK 475

                        250
                 ....*....|
gi 126302531 291 SLETLALTNN 300
Cdd:PLN00113 476 RLENLDLSRN 485
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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