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Conserved domains on  [gi|1261448144|gb|PFH01998|]
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YegS/Rv2252/BmrU family lipid kinase [Acetivibrio thermocellus AD2]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YegS_C super family cl29908
YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal ...
 1-292 5.61e-134

YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal domain found in the YegS protein. It is related to the beta sandwich domain of NAD kinases. The structure of YegS reveals a two-domain protein with the active site crevice found between the two domains. The C-terminal domain contains 13 beta-strands and two alpha-helices. The likely substrate for YegS is phosphatidylglycerol.


The actual alignment was detected with superfamily member PRK13059:

Pssm-ID: 453080  Cd Length: 295  Bit Score: 380.92  E-value: 5.61e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144   1 MDKALLVYNPFSGDRGIANKLDYILERFQQKDILLQPYRIMEGCGKNISDLLTEGSYKFVISSGGDGTLNFICNIIMKNN 80
Cdd:PRK13059    1 MKKVKFIYNPYSGENAIISELDKVIRIHQEKGYLVVPYRISLEYDLKNAFKDIDESYKYILIAGGDGTVDNVVNAMKKLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144  81 LSVPMGIIPAGTCNDFASILNIPTSVEECVDIILKGRTVDVDVGVVDDRiYFLSSCAGGVFVDVSFSTDGELKKNLGALA 160
Cdd:PRK13059   81 IDLPIGILPVGTANDFAKFLGMPTDIGEACEQILKSKPKKVDLGKINDK-YFINVASTGLFTDVSQKTDVNLKNTIGKLA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144 161 YYLKALTEMASMKPFRVTIETEEEIFEDDILLFCILNGNQAGGFHNLMDAVYDDGLMDIVIIKDCRKIELPAIFYKVINN 240
Cdd:PRK13059  160 YYLKGLEELPNFRKLKVKVTSEEVNFDGDMYLMLVFNGQTAGNFNLAYKAEVDDGLLDVIIIKACPIIDLIPLFIKVLKG 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1261448144 241 ELQNDKN-VVTIRTNRCTIKSSKEIVLSIDGEKGPTLPVEVKFINKALKVFAA 292
Cdd:PRK13059  240 EHLEDVNgLIYFKTDKLEIESNEEIVTDIDGERGPDFPLNIECIKGGLKVLGI 292
 
Name Accession Description Interval E-value
PRK13059 PRK13059
putative lipid kinase; Reviewed
 1-292 5.61e-134

putative lipid kinase; Reviewed


Pssm-ID: 183858  Cd Length: 295  Bit Score: 380.92  E-value: 5.61e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144   1 MDKALLVYNPFSGDRGIANKLDYILERFQQKDILLQPYRIMEGCGKNISDLLTEGSYKFVISSGGDGTLNFICNIIMKNN 80
Cdd:PRK13059    1 MKKVKFIYNPYSGENAIISELDKVIRIHQEKGYLVVPYRISLEYDLKNAFKDIDESYKYILIAGGDGTVDNVVNAMKKLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144  81 LSVPMGIIPAGTCNDFASILNIPTSVEECVDIILKGRTVDVDVGVVDDRiYFLSSCAGGVFVDVSFSTDGELKKNLGALA 160
Cdd:PRK13059   81 IDLPIGILPVGTANDFAKFLGMPTDIGEACEQILKSKPKKVDLGKINDK-YFINVASTGLFTDVSQKTDVNLKNTIGKLA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144 161 YYLKALTEMASMKPFRVTIETEEEIFEDDILLFCILNGNQAGGFHNLMDAVYDDGLMDIVIIKDCRKIELPAIFYKVINN 240
Cdd:PRK13059  160 YYLKGLEELPNFRKLKVKVTSEEVNFDGDMYLMLVFNGQTAGNFNLAYKAEVDDGLLDVIIIKACPIIDLIPLFIKVLKG 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1261448144 241 ELQNDKN-VVTIRTNRCTIKSSKEIVLSIDGEKGPTLPVEVKFINKALKVFAA 292
Cdd:PRK13059  240 EHLEDVNgLIYFKTDKLEIESNEEIVTDIDGERGPDFPLNIECIKGGLKVLGI 292
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 1-291 8.87e-65

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 205.09  E-value: 8.87e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144   1 MDKALLVYNPFSGDRGIANKLDYILERFQQKDILLQPYRIM-EGCGKNISDLLTEGSYKFVISSGGDGTLNFICNIIMKN 79
Cdd:COG1597     2 MMRALLIVNPASGRGRAARLLERLVAALRAAGLEVEVLETEsPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAGT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144  80 NlsVPMGIIPAGTCNDFASILNIPTSVEECVDIILKGRTvdvdvgvvdDRI--------YFLSSCAGGVFVDVSFSTDGE 151
Cdd:COG1597    82 G--PPLGILPLGTGNDFARALGIPLDPEAALEALLTGRT---------RRIdlgrvngrYFLNVAGIGFDAEVVERANRA 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144 152 LKKNLGALAYYLKALTEMASMKPFRVTIETEEEIFEDDILLFCILNGNQAGGFHNLM-DAVYDDGLMDIVIIKDCRKIEL 230
Cdd:COG1597   151 LKRRLGKLAYVLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLApDASLDDGLLDVVVVRPLSRLRL 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1261448144 231 PAIFYKVINNELQNDKNVVTIRTNRCTIKSSKEIVLSIDGEK-GPTLPVEVKFINKALKVFA 291
Cdd:COG1597   231 LRLLPRLLRGRHLRHPGVRYFRAREVEIESDRPLPVQLDGEPlGLATPLEFEVLPGALRVLV 292
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
 1-289 4.87e-36

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 130.70  E-value: 4.87e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144   1 MDKALLVYNPFSGDRGIANKLDYILERFQQKDILLQpYRIMEGCGKNISDLLTEGSYKF--VISSGGDGTLNFICNIIMK 78
Cdd:TIGR00147   1 MAEAPAILNPTAGKSNDNKPLREVIMLLREEGMEIH-VRVTWEKGDAARYVEEARKFGVdtVIAGGGDGTINEVVNALIQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144  79 NNLSVPMGIIPAGTCNDFASILNIPTSVEECVDIILKGRTVDVDVGVVDDRIYFLSSCAGGVFVDVSFSTDGELKKNLGA 158
Cdd:TIGR00147  80 LDDIPALGILPLGTANDFARSLGIPEDLDKAAKLVIAGDARAIDMGQVNKQYCFINMAGGGFGTEITTETPEKLKAALGS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144 159 LAYYLKALTEMASMKPFRVTIETEEEIFEDDILLFCILNGNQAGGFHNLM-DAVYDDGLMDIVIIKDCRKIELPAIFYKV 237
Cdd:TIGR00147 160 LSYILSGLMRMDTLQPFRCEIRGEGEHWQGEAVVFLVGNGRQAGGGQKLApDASINDGLLDLRIFTNDNLLPALVLTLMS 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1261448144 238 INNELQNDKNVVTIRTNRCTIKSSKEIVLSIDGEKGPTLPVEVKFINKALKV 289
Cdd:TIGR00147 240 DEGKHTDNPNIIYGKASRIDIQTPHKITFNLDGEPLGGTPFHIEILPAHLRC 291
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 3-118 9.02e-23

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 90.72  E-value: 9.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144   3 KALLVYNPFSGDRGIANKLDYILERFQQKDILLQPYRI-MEGCGKNISDLLTEGSYKFVISSGGDGTLNFICNIIMKNNL 81
Cdd:pfam00781   1 KLLVIVNPKSGGGKGKKLLRKVRPLLNKAGVEVELVLTeGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGLAT 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1261448144  82 SVPMGIIPAGTCNDFASILNIPTSVEECVDIILKGRT 118
Cdd:pfam00781  81 RPPLGIIPLGTGNDFARALGIPGDPEEALEAILKGQT 117
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
 5-104 7.71e-09

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 53.07  E-value: 7.71e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144    5 LLVYNPFSGDrgiaNKLDYILERFQqkdILLQPYRIME----GCGKNISDLLTEGSYKFVISSGGDGTLNFICNIIMKNN 80
Cdd:smart00046   1 LVFVNPKSGG----GKGEKLLRKFR---LLLNPRQVFDltkkGPAVALVIFRDVPDFNRVLVCGGDGTVGWVLNALDKRE 73

                           90       100
                   ....*....|....*....|....*..
gi 1261448144   81 L---SVPMGIIPAGTCNDFASILNIPT 104
Cdd:smart00046  74 LplpEPPVAVLPLGTGNDLARSLGWGG 100
 
Name Accession Description Interval E-value
PRK13059 PRK13059
putative lipid kinase; Reviewed
 1-292 5.61e-134

putative lipid kinase; Reviewed


Pssm-ID: 183858  Cd Length: 295  Bit Score: 380.92  E-value: 5.61e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144   1 MDKALLVYNPFSGDRGIANKLDYILERFQQKDILLQPYRIMEGCGKNISDLLTEGSYKFVISSGGDGTLNFICNIIMKNN 80
Cdd:PRK13059    1 MKKVKFIYNPYSGENAIISELDKVIRIHQEKGYLVVPYRISLEYDLKNAFKDIDESYKYILIAGGDGTVDNVVNAMKKLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144  81 LSVPMGIIPAGTCNDFASILNIPTSVEECVDIILKGRTVDVDVGVVDDRiYFLSSCAGGVFVDVSFSTDGELKKNLGALA 160
Cdd:PRK13059   81 IDLPIGILPVGTANDFAKFLGMPTDIGEACEQILKSKPKKVDLGKINDK-YFINVASTGLFTDVSQKTDVNLKNTIGKLA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144 161 YYLKALTEMASMKPFRVTIETEEEIFEDDILLFCILNGNQAGGFHNLMDAVYDDGLMDIVIIKDCRKIELPAIFYKVINN 240
Cdd:PRK13059  160 YYLKGLEELPNFRKLKVKVTSEEVNFDGDMYLMLVFNGQTAGNFNLAYKAEVDDGLLDVIIIKACPIIDLIPLFIKVLKG 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1261448144 241 ELQNDKN-VVTIRTNRCTIKSSKEIVLSIDGEKGPTLPVEVKFINKALKVFAA 292
Cdd:PRK13059  240 EHLEDVNgLIYFKTDKLEIESNEEIVTDIDGERGPDFPLNIECIKGGLKVLGI 292
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 1-291 8.87e-65

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 205.09  E-value: 8.87e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144   1 MDKALLVYNPFSGDRGIANKLDYILERFQQKDILLQPYRIM-EGCGKNISDLLTEGSYKFVISSGGDGTLNFICNIIMKN 79
Cdd:COG1597     2 MMRALLIVNPASGRGRAARLLERLVAALRAAGLEVEVLETEsPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAGT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144  80 NlsVPMGIIPAGTCNDFASILNIPTSVEECVDIILKGRTvdvdvgvvdDRI--------YFLSSCAGGVFVDVSFSTDGE 151
Cdd:COG1597    82 G--PPLGILPLGTGNDFARALGIPLDPEAALEALLTGRT---------RRIdlgrvngrYFLNVAGIGFDAEVVERANRA 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144 152 LKKNLGALAYYLKALTEMASMKPFRVTIETEEEIFEDDILLFCILNGNQAGGFHNLM-DAVYDDGLMDIVIIKDCRKIEL 230
Cdd:COG1597   151 LKRRLGKLAYVLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLApDASLDDGLLDVVVVRPLSRLRL 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1261448144 231 PAIFYKVINNELQNDKNVVTIRTNRCTIKSSKEIVLSIDGEK-GPTLPVEVKFINKALKVFA 291
Cdd:COG1597   231 LRLLPRLLRGRHLRHPGVRYFRAREVEIESDRPLPVQLDGEPlGLATPLEFEVLPGALRVLV 292
PRK13337 PRK13337
putative lipid kinase; Reviewed
 1-284 7.18e-48

putative lipid kinase; Reviewed


Pssm-ID: 183982 [Multi-domain]  Cd Length: 304  Bit Score: 161.75  E-value: 7.18e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144   1 MDKALLVYNPFSGDRGIANKLDYILERFQQKDILLQPYRIM-EGCGKNISDLLTEGSYKFVISSGGDGTLNFICNIIMKN 79
Cdd:PRK13337    1 MKRARIIYNPTSGRELFKKNLPDVLQKLEQAGYETSAHATTgPGDATLAAERAVERKFDLVIAAGGDGTLNEVVNGIAEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144  80 NLSVPMGIIPAGTCNDFASILNIPTSVEECVDIILKGRTVDVDVGVVDDRiYFLSSCAGGVFVDVSFSTDGELKKNLGAL 159
Cdd:PRK13337   81 ENRPKLGIIPVGTTNDFARALHVPRDIEKAADVIIEGHTVPVDIGKANNR-YFINIAGGGRLTELTYEVPSKLKTMLGQL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144 160 AYYLKALTEMASMKPFRVTIETEEEIFEDDILLFCILNGNQAGGFHNLM-DAVYDDGLMDIVIIKDCRKIELPAIFYKVI 238
Cdd:PRK13337  160 AYYLKGIEMLPSLKATDVRIEYDGKLFQGEIMLFLLGLTNSVGGFEKLApDASLDDGYFDLIIVKKANLAELIHIATLAL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1261448144 239 NNELQNDKNVVTIRTNRCTIKSSKEIVLSIDGEKGPTLPVEvkFIN 284
Cdd:PRK13337  240 RGEHIKHPKVIYTKANRIKVSSFDKMQLNLDGEYGGKLPAE--FEN 283
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
 1-289 4.87e-36

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 130.70  E-value: 4.87e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144   1 MDKALLVYNPFSGDRGIANKLDYILERFQQKDILLQpYRIMEGCGKNISDLLTEGSYKF--VISSGGDGTLNFICNIIMK 78
Cdd:TIGR00147   1 MAEAPAILNPTAGKSNDNKPLREVIMLLREEGMEIH-VRVTWEKGDAARYVEEARKFGVdtVIAGGGDGTINEVVNALIQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144  79 NNLSVPMGIIPAGTCNDFASILNIPTSVEECVDIILKGRTVDVDVGVVDDRIYFLSSCAGGVFVDVSFSTDGELKKNLGA 158
Cdd:TIGR00147  80 LDDIPALGILPLGTANDFARSLGIPEDLDKAAKLVIAGDARAIDMGQVNKQYCFINMAGGGFGTEITTETPEKLKAALGS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144 159 LAYYLKALTEMASMKPFRVTIETEEEIFEDDILLFCILNGNQAGGFHNLM-DAVYDDGLMDIVIIKDCRKIELPAIFYKV 237
Cdd:TIGR00147 160 LSYILSGLMRMDTLQPFRCEIRGEGEHWQGEAVVFLVGNGRQAGGGQKLApDASINDGLLDLRIFTNDNLLPALVLTLMS 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1261448144 238 INNELQNDKNVVTIRTNRCTIKSSKEIVLSIDGEKGPTLPVEVKFINKALKV 289
Cdd:TIGR00147 240 DEGKHTDNPNIIYGKASRIDIQTPHKITFNLDGEPLGGTPFHIEILPAHLRC 291
PRK13055 PRK13055
putative lipid kinase; Reviewed
 1-291 2.23e-35

putative lipid kinase; Reviewed


Pssm-ID: 237282 [Multi-domain]  Cd Length: 334  Bit Score: 129.73  E-value: 2.23e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144   1 MDKALLVYNPFSGDRGIANKLdyilerfqqKDILlqpyRIMEGCG---------------KNISDLLTEGSYKFVISSGG 65
Cdd:PRK13055    2 QKRARLIYNPTSGQEIMKKNV---------ADIL----DILEQAGyetsafqttpepnsaKNEAKRAAEAGFDLIIAAGG 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144  66 DGTLNFICNIIMKNNLSVPMGIIPAGTCNDFASILNIP-TSVEECVDIILKGRTVDVDVGVVDDRIYFLSSCAGGVFVDV 144
Cdd:PRK13055   69 DGTINEVVNGIAPLEKRPKMAIIPAGTTNDYARALKIPrDNPVEAAKVILKNQTIKMDIGRANEDKYFINIAAGGSLTEL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144 145 SFSTDGELKKNLGALAYYLKALTEMASMKPFRVTIETEEEIFEDDILLFCILNGNQAGGFHNLM-DAVYDDGLMDIVIIK 223
Cdd:PRK13055  149 TYSVPSQLKSMFGYLAYLAKGAELLPRVSPVPVRITYDEGVFEGKISMFFLALTNSVGGFEQIVpDAKLDDGKFTLIIVK 228

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1261448144 224 DCRKIELPAIFYKVINNELQ-NDKNVVTIRTNRCTIKS--SKEIVLSIDGEKGPTLPVEVKFINKALKVFA 291
Cdd:PRK13055  229 TANLFELLHLMALILNGGKHiDDPRVIYIKTSKLTIEPlgDDRLMVNLDGEYGGDAPMTFENLKQHIEFFA 299
PRK13054 PRK13054
lipid kinase; Reviewed
 60-271 2.46e-32

lipid kinase; Reviewed


Pssm-ID: 237281 [Multi-domain]  Cd Length: 300  Bit Score: 121.13  E-value: 2.46e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144  60 VISSGGDGTLNFICNIIMKNNLSVP--MGIIPAGTCNDFASILNIPTSVEECVDIILKGRTVDVDVGVVDDRIYFLSSCA 137
Cdd:PRK13054   60 VIAGGGDGTINEVATALAQLEGDARpaLGILPLGTANDFATAAGIPLEPDKALKLAIEGRAQPIDLARVNDRTYFINMAT 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144 138 GGVFVDVSFSTDGELKKNLGALAYYLKALTEMASMKPFRVTIETEEEIFEDDILLFCILNGNQAGGFHNLM-DAVYDDGL 216
Cdd:PRK13054  140 GGFGTRVTTETPEKLKAALGGVAYLIHGLMRMDTLKPDRCEIRGPDFHWQGDALVIGIGNGRQAGGGQQLCpEALINDGL 219

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1261448144 217 MDIVIIKDCRKIeLPAIFYKvINNELQNDKNVVTIRTNRCTIKSSKEIVLSIDGE 271
Cdd:PRK13054  220 LDLRILPAPQEL-LPTLLST-LTGGSEDNPNIIRARLPWLEIQAPHELTFNLDGE 272
PRK00861 PRK00861
putative lipid kinase; Reviewed
 1-291 2.33e-28

putative lipid kinase; Reviewed


Pssm-ID: 234850 [Multi-domain]  Cd Length: 300  Bit Score: 110.48  E-value: 2.33e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144   1 MDKALLVYNPFSGDRGIANKLDYILERFQQK---DILL-QPYRIMEGCGKnisDLLTEGSyKFVISSGGDGTLNFICNII 76
Cdd:PRK00861    2 TRSACLIFNPVAGQGNPEVDLALIRAILEPEmdlDIYLtTPEIGADQLAQ---EAIERGA-ELIIASGGDGTLSAVAGAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144  77 MKNNlsVPMGIIPAGTCNDFASILNIPTSVEECVDIILKGRTvdvdvgvvddRIYFLSSCAG---------GVFVDVSFS 147
Cdd:PRK00861   78 IGTD--IPLGIIPRGTANAFAAALGIPDTIEEACRTILQGKT----------RRVDVAYCNGqpmillagiGFEAETVEE 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144 148 TDGELKKNLGALAYYLKALTEMASMKPFRVTIETEEEIFEDDILLFCILNGNQ-----AGGFHNLmdaVYDDGLMDIVII 222
Cdd:PRK00861  146 ADREAKNRFGILAYILSGLQQLRELESFEVEIETEDQIITTNAVAVTVANAAPptsvlAQGPGAV---IPDDGLLDVTIV 222

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1261448144 223 KDCRKIELPAIFYKVI-----NNELQNDkNVVTIRTNRCTIKSSKEIVLSIDGEKGPTLPVEVKFINKALKVFA 291
Cdd:PRK00861  223 APKNLAEAVAASYHLLqtalqGNPAERD-DIGYLRAKQVKITTDPPQKVVIDGEVVGTTPIEIECLPRSLKVFA 295
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 3-118 9.02e-23

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 90.72  E-value: 9.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144   3 KALLVYNPFSGDRGIANKLDYILERFQQKDILLQPYRI-MEGCGKNISDLLTEGSYKFVISSGGDGTLNFICNIIMKNNL 81
Cdd:pfam00781   1 KLLVIVNPKSGGGKGKKLLRKVRPLLNKAGVEVELVLTeGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGLAT 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1261448144  82 SVPMGIIPAGTCNDFASILNIPTSVEECVDIILKGRT 118
Cdd:pfam00781  81 RPPLGIIPLGTGNDFARALGIPGDPEEALEAILKGQT 117
PRK13057 PRK13057
lipid kinase;
59-291 3.17e-22

lipid kinase;


Pssm-ID: 183857 [Multi-domain]  Cd Length: 287  Bit Score: 93.44  E-value: 3.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144  59 FVISSGGDGTLNFICNIIMKNNLsvPMGIIPAGTCNDFASILNIPTSVEECVDIILKGRTvdvdvgvvdDRI-------- 130
Cdd:PRK13057   53 LVIVGGGDGTLNAAAPALVETGL--PLGILPLGTANDLARTLGIPLDLEAAARVIATGQV---------RRIdlgwvngh 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144 131 YFLSSCAGGVFVDVSFSTDGELKKNLGALAYYLKALTEMASMKPFRVTIETEEEIFEDDILLFCILNGNQAGG----FHn 206
Cdd:PRK13057  122 YFFNVASLGLSAELARRLTKELKRRWGTLGYAIAALRVLRRSRPFTAEIEHDGRTERVKTLQVAVGNGRYYGGgmtvAH- 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144 207 lmDAVYDDGLMDI--VIIKDCRKieLPAIFYKVINNELQNDKNVVTIRTNRCTIKSSKEIVLSIDGEKGPTLPVEVKFIN 284
Cdd:PRK13057  201 --DATIDDGRLDLysLEVAHWWR--LLALLPALRRGRHGEWPDVRAFRTTELELRTRKPRPINTDGELTTYTPAHFRVLP 276


                  ....*..
gi 1261448144 285 KALKVFA 291
Cdd:PRK13057  277 KALRVLA 283
PRK11914 PRK11914
diacylglycerol kinase; Reviewed
 60-289 4.05e-10

diacylglycerol kinase; Reviewed


Pssm-ID: 237021 [Multi-domain]  Cd Length: 306  Bit Score: 59.41  E-value: 4.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144  60 VISSGGDGTLNFICNIIMKNNlsVPMGIIPAGTCNDFASILNIPT-SVEECVDIILKGRTVDV----DVGVVDDRIYFLS 134
Cdd:PRK11914   68 LVVVGGDGVISNALQVLAGTD--IPLGIIPAGTGNDHAREFGIPTgDPEAAADVIVDGWTETVdlgrIQDDDGIVKWFGT 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144 135 SCAGGVFVDVSFSTDgELKKNLGALAYYLKALTEMASMK--PFRVtIETEEEIFEDDILLFCILNGNQAGGFHNLM-DAV 211
Cdd:PRK11914  146 VAATGFDSLVTDRAN-RMRWPHGRMRYNLAMLAELSKLRplPFRL-VLDGTEEIVTDLTLAAFGNTRSYGGGMLICpNAD 223

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1261448144 212 YDDGLMDIVIIKDCRKIELPAIFYKVINNELQNDKNVVTIRTNRCTIKSSKeIVLSIDGEKGPTLPVEVKFINKALKV 289
Cdd:PRK11914  224 HTDGLLDITMVQSASRTRLLRLFPTVFKGTHVELDEVSTARAKTVHVECPG-INAYADGDFACPLPAEISAVPGALQI 300
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
 5-104 7.71e-09

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 53.07  E-value: 7.71e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144    5 LLVYNPFSGDrgiaNKLDYILERFQqkdILLQPYRIME----GCGKNISDLLTEGSYKFVISSGGDGTLNFICNIIMKNN 80
Cdd:smart00046   1 LVFVNPKSGG----GKGEKLLRKFR---LLLNPRQVFDltkkGPAVALVIFRDVPDFNRVLVCGGDGTVGWVLNALDKRE 73

                           90       100
                   ....*....|....*....|....*..
gi 1261448144   81 L---SVPMGIIPAGTCNDFASILNIPT 104
Cdd:smart00046  74 LplpEPPVAVLPLGTGNDLARSLGWGG 100
YegS_C pfam19279
YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal ...
 156-291 8.37e-08

YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal domain found in the YegS protein. It is related to the beta sandwich domain of NAD kinases. The structure of YegS reveals a two-domain protein with the active site crevice found between the two domains. The C-terminal domain contains 13 beta-strands and two alpha-helices. The likely substrate for YegS is phosphatidylglycerol.


Pssm-ID: 437111  Cd Length: 158  Bit Score: 50.66  E-value: 8.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144 156 LGALAYYLKALTEMASMKPFRVTIETEEEIFEDDILLFCILNGNQAG-GFHNLMDAVYDDGLMDIVIIKDCRKIELPAIF 234
Cdd:pfam19279  22 PGALSYPAAALRALATFRPLRYRVTVDGEVREFSAALVAVANSGYYGgGMRIAPDARVDDGLLDVVVIEAASRRTLLRLL 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1261448144 235 YKVINNELQNDKNVVTIRTNRCTIKSSKEIVLSIDGEKGPTLPVEVKFINKALKVFA 291
Cdd:pfam19279 102 PKVYDGRHVRLPQVEVLRGREVRIEADRPLPAGADGEVLGPLPVRVEVLPGALRVLA 158
PRK12361 PRK12361
hypothetical protein; Provisional
 3-292 4.30e-06

hypothetical protein; Provisional


Pssm-ID: 183473 [Multi-domain]  Cd Length: 547  Bit Score: 47.69  E-value: 4.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144   3 KALLVYNPFSGDRGIANKLDYILERFQQKdillqpYRI-MEGCGKNIS-DLLTEGSYK----FVISSGGDGTLNFICNII 76
Cdd:PRK12361  244 RAWLIANPVSGGGKWQEYGEQIQRELKAY------FDLtVKLTTPEISaEALAKQARKagadIVIACGGDGTVTEVASEL 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144  77 MKNNLSvpMGIIPAGTCNDFASIL------NIPtsVEECVDIILKGRTVDVDVGVVDDRIYFLsscaggvFVDVSF---- 146
Cdd:PRK12361  318 VNTDIT--LGIIPLGTANALSHALfglgskLIP--VEQACDNIIQGHTQRIDTARCNDRLMLL-------LVGIGFeqkm 386

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144 147 --STDGELKKNLGALAY---YLKALTEMASMK---------PFRVTIETeeeifeddillFCILNGN-------QAGGFH 205
Cdd:PRK12361  387 ieSADRERKNALGQLAYldgLWRAVNENETLTltvtlddaePQTISTHS-----------LVVANAApftsllaQGGGEP 455

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1261448144 206 NlmdavYDDGLMDIVIIKDCRKI--------ELpaIFYKVINNELQNdkNVVTIRTNRCTIKSSKEIVLSIDGEKGPTLP 277
Cdd:PRK12361  456 N-----MTDGLLDITWLDSGGEPgeqllslaEL--ALSGLGKEPEAN--KVHHAHAKKVTISSQKPIKYVIDGELFEDED 526

                         330
                  ....*....|....*
gi 1261448144 278 VEVKFINKALKVFAA 292
Cdd:PRK12361  527 LTIEVQPASLKVFVP 541
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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