|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
506-794 |
2.78e-19 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 91.53 E-value: 2.78e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 506 TLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNSISQTLNGSEFQPLVELKYLDFSNNRldllystAFEELHNLEVLDISSN 585
Cdd:COG4886 51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGN 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 586 ShyfqsegITHMLNFTKNLKVLRKLMMNYNDIATstsrtmeseslqilefrgnhldilwrdgdnrYLKFFKNLLNLEELD 665
Cdd:COG4886 124 Q-------LTDLPEELANLTNLKELDLSNNQLTD-------------------------------LPEPLGNLTNLKSLD 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 666 ISENSLSFLPLGVFDSmpPNLKTLSLAKNGLKSFSWErLQSLKNLETLDLSFNQLKTVPERLSNCSrSLKKLILKNNQIR 745
Cdd:COG4886 166 LSNNQLTDLPEELGNL--TNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEPLANLT-NLETLDLSNNQLT 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 126033176 746 CLTKyfLQGAFQLRHLDLSSNKIqviqkTSFPENV-LNNLNILFLHHNRF 794
Cdd:COG4886 242 DLPE--LGNLTNLEELDLSNNQL-----TDLPPLAnLTNLKTLDLSNNQL 284
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
128-334 |
1.53e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 80.36 E-value: 1.53e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 128 PNSFSKLTYLKSLYLDGNQLLEIPqdlppslqllsleanniflimkENLTELANLEILYLGQNcyyrnpcnvSFTIEKDA 207
Cdd:COG4886 106 NEELSNLTNLESLDLSGNQLTDLP----------------------EELANLTNLKELDLSNN---------QLTDLPEP 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 208 FLNMRNLKLLSLKDNNISAVPTVLP--SSLTELYLYNNIITKIQEdDFNNLSQLQVLDLSGNcprcynvpfpctpcenns 285
Cdd:COG4886 155 LGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGN------------------ 215
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 126033176 286 PLQIDPNAFDALTELQVLRLHSNSLQHVPqrWFKNINKLKELDLSQNFL 334
Cdd:COG4886 216 QLTDLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
|
|
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
899-1044 |
1.58e-13 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 68.89 E-value: 1.58e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 899 CYDAFIVYdtkdpAVTEWVLDELVAKLEDpREKCFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKI 978
Cdd:smart00255 1 EYDVFISY-----SGKEDVRNEFLSHLLE-KLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLD 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 979 AFYLSHQRLMDEKVDVIILIFLEK----PLQKSKFLQLRKRlcgSSVLEWPTNPQAHpyFWQCLKNALAT 1044
Cdd:smart00255 75 ELVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFK---KNYLKWPEDEKEQ--FWKKALYAVPS 139
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
254-793 |
9.75e-11 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 66.02 E-value: 9.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 254 NNLSQLQVLDLSGNcprcynvpfpctpcenNSPLQIDPNAFdALTELQVLRLHSNSLQ-HVPQRWFKNINKLKELDLSQN 332
Cdd:PLN00113 66 NNSSRVVSIDLSGK----------------NISGKISSAIF-RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNN 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 333 FLAKEIGDAkflhLLHNLVNLDLSFNydlQVYHAVINLSDAFSSLKklkVLRIKGYVF--KELNSLNlfplhNLPNLEVL 410
Cdd:PLN00113 129 NFTGSIPRG----SIPNLETLDLSNN---MLSGEIPNDIGSFSSLK---VLDLGGNVLvgKIPNSLT-----NLTSLEFL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 411 DLGTNFIKIANLSIFNQFKTLKFIDLSVNKISpsGDSPE--GGFCSNRR-----TSVEGHGPQV---LETLHY-FRYDEy 479
Cdd:PLN00113 194 TLASNQLVGQIPRELGQMKSLKWIYLGYNNLS--GEIPYeiGGLTSLNHldlvyNNLTGPIPSSlgnLKNLQYlFLYQN- 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 480 arscRSKSKEPPSFLPLNEDCymygqTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNSISQTLNGSeFQPLVELKYLDFS 559
Cdd:PLN00113 271 ----KLSGPIPPSIFSLQKLI-----SLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVA-LTSLPRLQVLQLW 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 560 NNRLDLLYSTAFEELHNLEVLDISSNShyfQSEGITHMLNFTKNLKvlrKLMMNYNDI------ATSTSRTMESESLQIL 633
Cdd:PLN00113 341 SNKFSGEIPKNLGKHNNLTVLDLSTNN---LTGEIPEGLCSSGNLF---KLILFSNSLegeipkSLGACRSLRRVRLQDN 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 634 EFRGNhldiLWRDGDNRYLKFFknllnleeLDISENSLSflplGVFDSMP---PNLKTLSLAKNglkSFSWERLQSL--K 708
Cdd:PLN00113 415 SFSGE----LPSEFTKLPLVYF--------LDISNNNLQ----GRINSRKwdmPSLQMLSLARN---KFFGGLPDSFgsK 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 709 NLETLDLSFNQLK-TVPERLSNCSRsLKKLILKNNQIRCLTKYFLQGAFQLRHLDLSSNKIQVIQKTSFPE-NVLNNLNi 786
Cdd:PLN00113 476 RLENLDLSRNQFSgAVPRKLGSLSE-LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEmPVLSQLD- 553
|
....*..
gi 126033176 787 lfLHHNR 793
Cdd:PLN00113 554 --LSQNQ 558
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
116-315 |
2.42e-09 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 61.64 E-value: 2.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 116 KDNVCTKRLQIKPNSFSKLTYLKSLYLDGNQLLEIPQDLPPSLQLLSLEANNIFLImKENLTElaNLEILYLGQNCYYRN 195
Cdd:PRK15370 180 KTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSI-PATLPD--TIQEMELSINRITEL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 196 PCNVSFTIEK-DAFLNM---------RNLKLLSLKDNNISAVPTVLPSSLTELYLYNNIIT----------KIQEDDFNN 255
Cdd:PRK15370 257 PERLPSALQSlDLFHNKisclpenlpEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTalpetlppglKTLEAGENA 336
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 126033176 256 LS--------QLQVLDLSGNCPRCYNVPFPCTPCEnnspLQIDPNAFDALTE-----LQVLRLHSNSLQHVPQ 315
Cdd:PRK15370 337 LTslpaslppELQVLDVSKNQITVLPETLPPTITT----LDVSRNALTNLPEnlpaaLQIMQASRNNLVRLPE 405
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
206-334 |
8.78e-09 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 57.10 E-value: 8.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 206 DAFLNMRNLKLLSLKDNNISAVPTVLP-SSLTELYLYNNIITKIqeDDFNNLSQLQVLDLSGNCPRC----YNvpfpctp 280
Cdd:cd21340 18 DNLSLCKNLKVLYLYDNKITKIENLEFlTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVveglEN------- 88
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 126033176 281 CEN-------------NSPLQIDPNAFDALTE-LQVLRLHSNSLQHVpqRWFKNINKLKELDLSQNFL 334
Cdd:cd21340 89 LTNleelhienqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
900-1025 |
1.69e-08 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 55.06 E-value: 1.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 900 YDAFIVYDTKDpaVTEWVLDELVAKLedpREKCFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKT----EN 975
Cdd:pfam01582 1 YDVFLSFRGSD--TREWFVSHLLKEL---KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgwclDE 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 126033176 976 FKIAfylshQRLMDEKVDVIILIFLEK-----PLQKSKFLQLRKRLCG----SSVLEWP 1025
Cdd:pfam01582 76 LVKI-----LECALDLGQKVIPIFYEVdpsdvRKQTGSFGKAFKKHKKvlteEKVLKWR 129
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
505-563 |
4.26e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 50.60 E-value: 4.26e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 126033176 505 QTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNSISqTLNGSEFQPLVELKYLDFSNNRL 563
Cdd:pfam13855 4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT-TLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
648-792 |
1.11e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 53.64 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 648 DNR--YLKFFKNLLNLEELDISENSLSFLPlgVFDSMPpNLKTLSLAKNGLKSFswERLQSLKNLETLDLSFNQLKT--- 722
Cdd:cd21340 33 DNKitKIENLEFLTNLTHLYLQNNQIEKIE--NLENLV-NLKKLYLGGNRISVV--EGLENLTNLEELHIENQRLPPgek 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 126033176 723 ---VPERLSNCSRSLKKLILKNNQIRCLTkyFLQGAFQLRHLDLSSNKIQVIQKTSFPENVLNNLNILFLHHN 792
Cdd:cd21340 108 ltfDPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
372-585 |
2.94e-06 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 49.40 E-value: 2.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 372 DAFSSLKKLKVLrikgYVFKelNSLNLFP-LHNLPNLEVLDLGTNFI-KIANLsifNQFKTLKFIDLSVNKISpsgdspe 449
Cdd:cd21340 18 DNLSLCKNLKVL----YLYD--NKITKIEnLEFLTNLTHLYLQNNQIeKIENL---ENLVNLKKLYLGGNRIS------- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 450 ggfcsnrrtSVEG-HGPQVLETLHYfrydEYARscrskskeppsfLPLnedcymyGQTLDLSRNNIFFIKPSdfqhlsfL 528
Cdd:cd21340 82 ---------VVEGlENLTNLEELHI----ENQR------------LPP-------GEKLTFDPRSLAALSNS-------L 122
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 126033176 529 KCLNLSGNSISqtlNGSEFQPLVELKYLDFSNNRLDLL--YSTAFEELHNLEVLDISSN 585
Cdd:cd21340 123 RVLNISGNNID---SLEPLAPLRNLEQLDASNNQISDLeeLLDLLSSWPSLRELDLTGN 178
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
233-310 |
4.95e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.82 E-value: 4.95e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 126033176 233 SSLTELYLYNNIITKIQEDDFNNLSQLQVLDLSGNCPRCynvpfpctpcennsplqIDPNAFDALTELQVLRLHSNSL 310
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-----------------LSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
762-846 |
1.24e-05 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 49.70 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 762 DLSSNKIQVIQKTSFpeNVLNNLNILFLHHNRFLCNCDAVWFVWWVNHTEVTI--PYLAtdvTCMGPGAHKGQSVVSLDL 839
Cdd:TIGR00864 1 DISNNKISTIEEGIC--ANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqPEAA---LCAGPGALAGQPLLGIPL 75
|
....*..
gi 126033176 840 YTCELDL 846
Cdd:TIGR00864 76 LDSGCDE 82
|
|
| LRR_12 |
pfam18837 |
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ... |
407-436 |
1.59e-05 |
|
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.
Pssm-ID: 408607 Cd Length: 30 Bit Score: 42.72 E-value: 1.59e-05
10 20 30
....*....|....*....|....*....|
gi 126033176 407 LEVLDLGTNFIKIANLSIFNQFKTLKFIDL 436
Cdd:pfam18837 1 LQTLHLQMNFINQAQLSIFGAFPGLRFVDL 30
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
74-147 |
6.48e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 41.74 E-value: 6.48e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 126033176 74 NATNLTLTINHIAGISPASFHRLDHLVEIDFRCNCVPVrlgpkdnvctkrlqIKPNSFSKLTYLKSLYLDGNQL 147
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--------------LSPGAFSGLPSLRYLDLSGNRL 61
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
506-794 |
2.78e-19 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 91.53 E-value: 2.78e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 506 TLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNSISQTLNGSEFQPLVELKYLDFSNNRldllystAFEELHNLEVLDISSN 585
Cdd:COG4886 51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGN 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 586 ShyfqsegITHMLNFTKNLKVLRKLMMNYNDIATstsrtmeseslqilefrgnhldilwrdgdnrYLKFFKNLLNLEELD 665
Cdd:COG4886 124 Q-------LTDLPEELANLTNLKELDLSNNQLTD-------------------------------LPEPLGNLTNLKSLD 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 666 ISENSLSFLPLGVFDSmpPNLKTLSLAKNGLKSFSWErLQSLKNLETLDLSFNQLKTVPERLSNCSrSLKKLILKNNQIR 745
Cdd:COG4886 166 LSNNQLTDLPEELGNL--TNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEPLANLT-NLETLDLSNNQLT 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 126033176 746 CLTKyfLQGAFQLRHLDLSSNKIqviqkTSFPENV-LNNLNILFLHHNRF 794
Cdd:COG4886 242 DLPE--LGNLTNLEELDLSNNQL-----TDLPPLAnLTNLKTLDLSNNQL 284
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
505-848 |
3.50e-17 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 85.37 E-value: 3.50e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 505 QTLDLSRNNiffikpsDFQHLSFLKCLNLSGNSISQTlnGSEFQPLVELKYLDFSNNRLDLLySTAFEELHNLEVLDISS 584
Cdd:COG4886 99 TELDLSGNE-------ELSNLTNLESLDLSGNQLTDL--PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSN 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 585 NshyfqseGITHMLNFTKNLKVLRKLMMNYNDIATSTSRTMESESLQILEFRGNHLDILwrdgdnryLKFFKNLLNLEEL 664
Cdd:COG4886 169 N-------QLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL--------PEPLANLTNLETL 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 665 DISENSLSFLPlgVFDSMPpNLKTLSLAKNGLKSFSweRLQSLKNLETLDLSFNQLKTVP-ERLSNCSRSLKKLILKNNQ 743
Cdd:COG4886 234 DLSNNQLTDLP--ELGNLT-NLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLL 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 744 IRCLTKYFLQGAFQLRHLDLSSNKIQVIQKTSFPENVLNNLNILFLHHNRFLCNCDAVWFVWWVNHTEVTIPYLATDVTC 823
Cdd:COG4886 309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388
|
330 340
....*....|....*....|....*
gi 126033176 824 MGPGAHKGQSVVSLDLYTCELDLTN 848
Cdd:COG4886 389 LLLLLLTTTAGVLLLTLALLDAVNT 413
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
128-334 |
1.53e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 80.36 E-value: 1.53e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 128 PNSFSKLTYLKSLYLDGNQLLEIPqdlppslqllsleanniflimkENLTELANLEILYLGQNcyyrnpcnvSFTIEKDA 207
Cdd:COG4886 106 NEELSNLTNLESLDLSGNQLTDLP----------------------EELANLTNLKELDLSNN---------QLTDLPEP 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 208 FLNMRNLKLLSLKDNNISAVPTVLP--SSLTELYLYNNIITKIQEdDFNNLSQLQVLDLSGNcprcynvpfpctpcenns 285
Cdd:COG4886 155 LGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGN------------------ 215
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 126033176 286 PLQIDPNAFDALTELQVLRLHSNSLQHVPqrWFKNINKLKELDLSQNFL 334
Cdd:COG4886 216 QLTDLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
124-442 |
3.57e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 79.21 E-value: 3.57e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 124 LQIKPNSFSKLTYLKSLYLDGNQLLEIPQDLPPSLQLLSLEANNIFLIMKENLTELANLEILYLGQNCYYRNPCNVSFTI 203
Cdd:COG4886 8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 204 EKDAFLNMRNLKLLSLKDNNISAVPTvlpsSLTELYLYNNIITKIqEDDFNNLSQLQVLDLSGNcprcynvpfpctpcen 283
Cdd:COG4886 88 GLTDLGDLTNLTELDLSGNEELSNLT----NLESLDLSGNQLTDL-PEELANLTNLKELDLSNN---------------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 284 nsPLQIDPNAFDALTELQVLRLHSNSLQHVPqRWFKNINKLKELDLSQN---FLAKEIGDAKflhllhNLVNLDLSFNyd 360
Cdd:COG4886 147 --QLTDLPEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNqitDLPEPLGNLT------NLEELDLSGN-- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 361 lqvyhAVINLSDAFSSLKKLKVLRIKGyvfkelNSLNLFP-LHNLPNLEVLDLGTNfiKIANLSIFNQFKTLKFIDLSVN 439
Cdd:COG4886 216 -----QLTDLPEPLANLTNLETLDLSN------NQLTDLPeLGNLTNLEELDLSNN--QLTDLPPLANLTNLKTLDLSNN 282
|
...
gi 126033176 440 KIS 442
Cdd:COG4886 283 QLT 285
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
128-440 |
1.37e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 77.28 E-value: 1.37e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 128 PNSFSKLTYLKSLYLDGNQLLEIPqdlppslqllsleanniflimkENLTELANLEILYLGQNcyyrnpcnvSFTIEKDA 207
Cdd:COG4886 129 PEELANLTNLKELDLSNNQLTDLP----------------------EPLGNLTNLKSLDLSNN---------QLTDLPEE 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 208 FLNMRNLKLLSLKDNNISAVPTVL--PSSLTELYLYNNIITKIqEDDFNNLSQLQVLDLSGNcprcynvpfpctpcenns 285
Cdd:COG4886 178 LGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN------------------ 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 286 plQI-DPNAFDALTELQVLRLHSNSLQHVPQrwFKNINKLKELDLSQNFLAK-EIGDAKFLHLLHNLVNLDLSFNYDLQV 363
Cdd:COG4886 239 --QLtDLPELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDlKLKELELLLGLNSLLLLLLLLNLLELL 314
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 126033176 364 YHAVINLSDAFSSLKKLKVLRIKGYVFKELNSLNLFPLHNLPNLEVLDLGTNFIKIANLSIFNQFKTLKFIDLSVNK 440
Cdd:COG4886 315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
613-794 |
1.24e-13 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 74.20 E-value: 1.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 613 NYNDIATSTSRTMESESLQILEFRGNHLDILWRDGDNRYLKFFKNLLNLEELDISENSlsflPLGVFdsmpPNLKTLSLA 692
Cdd:COG4886 50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE----ELSNL----TNLESLDLS 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 693 KNGLKSFSWErLQSLKNLETLDLSFNQLKTVPERLSNCSrSLKKLILKNNQIRCLTKyFLQGAFQLRHLDLSSNKIqviq 772
Cdd:COG4886 122 GNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPLGNLT-NLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQI---- 194
|
170 180
....*....|....*....|....
gi 126033176 773 kTSFPENV--LNNLNILFLHHNRF 794
Cdd:COG4886 195 -TDLPEPLgnLTNLEELDLSGNQL 217
|
|
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
899-1044 |
1.58e-13 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 68.89 E-value: 1.58e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 899 CYDAFIVYdtkdpAVTEWVLDELVAKLEDpREKCFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKI 978
Cdd:smart00255 1 EYDVFISY-----SGKEDVRNEFLSHLLE-KLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLD 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 979 AFYLSHQRLMDEKVDVIILIFLEK----PLQKSKFLQLRKRlcgSSVLEWPTNPQAHpyFWQCLKNALAT 1044
Cdd:smart00255 75 ELVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFK---KNYLKWPEDEKEQ--FWKKALYAVPS 139
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
254-793 |
9.75e-11 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 66.02 E-value: 9.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 254 NNLSQLQVLDLSGNcprcynvpfpctpcenNSPLQIDPNAFdALTELQVLRLHSNSLQ-HVPQRWFKNINKLKELDLSQN 332
Cdd:PLN00113 66 NNSSRVVSIDLSGK----------------NISGKISSAIF-RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNN 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 333 FLAKEIGDAkflhLLHNLVNLDLSFNydlQVYHAVINLSDAFSSLKklkVLRIKGYVF--KELNSLNlfplhNLPNLEVL 410
Cdd:PLN00113 129 NFTGSIPRG----SIPNLETLDLSNN---MLSGEIPNDIGSFSSLK---VLDLGGNVLvgKIPNSLT-----NLTSLEFL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 411 DLGTNFIKIANLSIFNQFKTLKFIDLSVNKISpsGDSPE--GGFCSNRR-----TSVEGHGPQV---LETLHY-FRYDEy 479
Cdd:PLN00113 194 TLASNQLVGQIPRELGQMKSLKWIYLGYNNLS--GEIPYeiGGLTSLNHldlvyNNLTGPIPSSlgnLKNLQYlFLYQN- 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 480 arscRSKSKEPPSFLPLNEDCymygqTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNSISQTLNGSeFQPLVELKYLDFS 559
Cdd:PLN00113 271 ----KLSGPIPPSIFSLQKLI-----SLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVA-LTSLPRLQVLQLW 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 560 NNRLDLLYSTAFEELHNLEVLDISSNShyfQSEGITHMLNFTKNLKvlrKLMMNYNDI------ATSTSRTMESESLQIL 633
Cdd:PLN00113 341 SNKFSGEIPKNLGKHNNLTVLDLSTNN---LTGEIPEGLCSSGNLF---KLILFSNSLegeipkSLGACRSLRRVRLQDN 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 634 EFRGNhldiLWRDGDNRYLKFFknllnleeLDISENSLSflplGVFDSMP---PNLKTLSLAKNglkSFSWERLQSL--K 708
Cdd:PLN00113 415 SFSGE----LPSEFTKLPLVYF--------LDISNNNLQ----GRINSRKwdmPSLQMLSLARN---KFFGGLPDSFgsK 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 709 NLETLDLSFNQLK-TVPERLSNCSRsLKKLILKNNQIRCLTKYFLQGAFQLRHLDLSSNKIQVIQKTSFPE-NVLNNLNi 786
Cdd:PLN00113 476 RLENLDLSRNQFSgAVPRKLGSLSE-LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEmPVLSQLD- 553
|
....*..
gi 126033176 787 lfLHHNR 793
Cdd:PLN00113 554 --LSQNQ 558
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
198-720 |
2.24e-10 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 64.87 E-value: 2.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 198 NVSFTIEKDAFLNMRNLKLLSLKDNNIS-AVPTVLPSSLTELYLYNNIITKIQEDDFNNLSQLQVLDLSGNCprcynvpf 276
Cdd:PLN00113 104 QLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNV-------- 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 277 pctpcennsPLQIDPNAFDALTELQVLRLHSNSLQHVPQRWFKNINKLKELDLSQNFLAKEIgdAKFLHLLHNLVNLDLS 356
Cdd:PLN00113 176 ---------LVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEI--PYEIGGLTSLNHLDLV 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 357 FNydlqvyhaviNLSDAF-SSLKKLKVLRikgYVFKELNSLN-LFP--LHNLPNLEVLDLGTNFI--KIANLSIfnQFKT 430
Cdd:PLN00113 245 YN----------NLTGPIpSSLGNLKNLQ---YLFLYQNKLSgPIPpsIFSLQKLISLDLSDNSLsgEIPELVI--QLQN 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 431 LKFIDLSVNKIspSGDSPeGGFCSNRRTsveghgpQVLEtLHYFRYdeyarscrskSKEPPSFLPLNEDCymygQTLDLS 510
Cdd:PLN00113 310 LEILHLFSNNF--TGKIP-VALTSLPRL-------QVLQ-LWSNKF----------SGEIPKNLGKHNNL----TVLDLS 364
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 511 RNNIFFIKPSDFQHLSFLKCLNLSGNSISQTLNGSeFQPLVELKYLDFSNNRLDLLYSTAFEELHNLEVLDISSNshyfq 590
Cdd:PLN00113 365 TNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKS-LGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNN----- 438
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 591 segithmlNFTKNLkvlrklmmnyndiatsTSRTMESESLQILEFRGNhldilwrdgdnrylKFFKNL------LNLEEL 664
Cdd:PLN00113 439 --------NLQGRI----------------NSRKWDMPSLQMLSLARN--------------KFFGGLpdsfgsKRLENL 480
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 126033176 665 DISENSLS-FLPLGvFDSMpPNLKTLSLAKNGLKSFSWERLQSLKNLETLDLSFNQL 720
Cdd:PLN00113 481 DLSRNQFSgAVPRK-LGSL-SELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
164-442 |
2.28e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 60.72 E-value: 2.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 164 EANNIFLIMKENLTELANLEILYLGQNCYYRNPCNVSFTIEKDAFLNMRNLKLLSLKDNNISAVPTVLPSSLTELYLYNN 243
Cdd:COG4886 3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 244 IITKIQEDDFNNLSQLQVLDLSGNCPrcynvPFPCTPCE----NNSPLQIDPNAFDALTELQVLRLHSNSLQHVPqRWFK 319
Cdd:COG4886 83 SLLLLGLTDLGDLTNLTELDLSGNEE-----LSNLTNLEsldlSGNQLTDLPEELANLTNLKELDLSNNQLTDLP-EPLG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 320 NINKLKELDLSQNFLA---KEIGDAKflhllhNLVNLDLSFNydlqvyhAVINLSDAFSSLKKLKVLRIKGyvfKELNSL 396
Cdd:COG4886 157 NLTNLKSLDLSNNQLTdlpEELGNLT------NLKELDLSNN-------QITDLPEPLGNLTNLEELDLSG---NQLTDL 220
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 126033176 397 NLfPLHNLPNLEVLDLGTNfiKIANLSIFNQFKTLKFIDLSVNKIS 442
Cdd:COG4886 221 PE-PLANLTNLETLDLSNN--QLTDLPELGNLTNLEELDLSNNQLT 263
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
116-315 |
2.42e-09 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 61.64 E-value: 2.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 116 KDNVCTKRLQIKPNSFSKLTYLKSLYLDGNQLLEIPQDLPPSLQLLSLEANNIFLImKENLTElaNLEILYLGQNCYYRN 195
Cdd:PRK15370 180 KTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSI-PATLPD--TIQEMELSINRITEL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 196 PCNVSFTIEK-DAFLNM---------RNLKLLSLKDNNISAVPTVLPSSLTELYLYNNIIT----------KIQEDDFNN 255
Cdd:PRK15370 257 PERLPSALQSlDLFHNKisclpenlpEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTalpetlppglKTLEAGENA 336
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 126033176 256 LS--------QLQVLDLSGNCPRCYNVPFPCTPCEnnspLQIDPNAFDALTE-----LQVLRLHSNSLQHVPQ 315
Cdd:PRK15370 337 LTslpaslppELQVLDVSKNQITVLPETLPPTITT----LDVSRNALTNLPEnlpaaLQIMQASRNNLVRLPE 405
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
206-334 |
8.78e-09 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 57.10 E-value: 8.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 206 DAFLNMRNLKLLSLKDNNISAVPTVLP-SSLTELYLYNNIITKIqeDDFNNLSQLQVLDLSGNCPRC----YNvpfpctp 280
Cdd:cd21340 18 DNLSLCKNLKVLYLYDNKITKIENLEFlTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVveglEN------- 88
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 126033176 281 CEN-------------NSPLQIDPNAFDALTE-LQVLRLHSNSLQHVpqRWFKNINKLKELDLSQNFL 334
Cdd:cd21340 89 LTNleelhienqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
900-1025 |
1.69e-08 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 55.06 E-value: 1.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 900 YDAFIVYDTKDpaVTEWVLDELVAKLedpREKCFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKT----EN 975
Cdd:pfam01582 1 YDVFLSFRGSD--TREWFVSHLLKEL---KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgwclDE 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 126033176 976 FKIAfylshQRLMDEKVDVIILIFLEK-----PLQKSKFLQLRKRLCG----SSVLEWP 1025
Cdd:pfam01582 76 LVKI-----LECALDLGQKVIPIFYEVdpsdvRKQTGSFGKAFKKHKKvlteEKVLKWR 129
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
505-563 |
4.26e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 50.60 E-value: 4.26e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 126033176 505 QTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNSISqTLNGSEFQPLVELKYLDFSNNRL 563
Cdd:pfam13855 4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT-TLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
648-792 |
1.11e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 53.64 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 648 DNR--YLKFFKNLLNLEELDISENSLSFLPlgVFDSMPpNLKTLSLAKNGLKSFswERLQSLKNLETLDLSFNQLKT--- 722
Cdd:cd21340 33 DNKitKIENLEFLTNLTHLYLQNNQIEKIE--NLENLV-NLKKLYLGGNRISVV--EGLENLTNLEELHIENQRLPPgek 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 126033176 723 ---VPERLSNCSRSLKKLILKNNQIRCLTkyFLQGAFQLRHLDLSSNKIQVIQKTSFPENVLNNLNILFLHHN 792
Cdd:cd21340 108 ltfDPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
56-267 |
1.47e-07 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 54.94 E-value: 1.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 56 IVDCTDKHLTEIPGGIpANATNLT---LTINHIAGIsPASFHRLDHLVEIDFRCNcvpvrlgpkdnvctkRLQIKPNSFS 132
Cdd:COG4886 140 ELDLSNNQLTDLPEPL-GNLTNLKsldLSNNQLTDL-PEELGNLTNLKELDLSNN---------------QITDLPEPLG 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 133 KLTYLKSLYLDGNQLLEIPqdlppslqllsleanniflimkENLTELANLEILYLGQNcyyrnpcNVSftiEKDAFLNMR 212
Cdd:COG4886 203 NLTNLEELDLSGNQLTDLP----------------------EPLANLTNLETLDLSNN-------QLT---DLPELGNLT 250
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 126033176 213 NLKLLSLKDNNISAVPTVLP-SSLTELYLYNNIITKIQEDDFNNLSQLQVLDLSGN 267
Cdd:COG4886 251 NLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
684-744 |
2.04e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 48.67 E-value: 2.04e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126033176 684 PNLKTLSLAKNGLKSFSWERLQSLKNLETLDLSFNQLKTVPERLSNCSRSLKKLILKNNQI 744
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
131-267 |
7.39e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 51.33 E-value: 7.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 131 FSKLTYLKSLYLDGNQLLEIpqdlppslqllsleanniflimkENLTELANLEILYLGQNC------------------- 191
Cdd:cd21340 42 LEFLTNLTHLYLQNNQIEKI-----------------------ENLENLVNLKKLYLGGNRisvveglenltnleelhie 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 192 YYRNPCNVSFTIEKDAFLNMRN-LKLLSLKDNNISAV-PTVLPSSLTELYLYNNIITKIQE--DDFNNLSQLQVLDLSGN 267
Cdd:cd21340 99 NQRLPPGEKLTFDPRSLAALSNsLRVLNISGNNIDSLePLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
628-768 |
9.71e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.97 E-value: 9.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 628 ESLQILEFRGNHLDilwRDGDN--RYLKFFKNLLNLEELDISENSLSFLPLGVFDSM----------------------- 682
Cdd:cd00116 51 PSLKELCLSLNETG---RIPRGlqSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLlrssslqelklnnnglgdrglrl 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 683 --------PPNLKTLSLAKNGLKSFSWER----LQSLKNLETLDLSFNQL------KTVPERLSNCsrSLKKLILKNNQI 744
Cdd:cd00116 128 lakglkdlPPALEKLVLGRNRLEGASCEAlakaLRANRDLKELNLANNGIgdagirALAEGLKANC--NLEVLDLNNNGL 205
|
170 180
....*....|....*....|....*...
gi 126033176 745 RCLTKYFLQGAF----QLRHLDLSSNKI 768
Cdd:cd00116 206 TDEGASALAETLaslkSLEVLNLGDNNL 233
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
664-792 |
2.76e-06 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 51.62 E-value: 2.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 664 LDISENSLSFLPlgvfDSMPPNLKTLSLAKNGLKSFSwERLQSlkNLETLDLSFNQLKTVPERLSNcsrSLKKLILKNNQ 743
Cdd:PRK15370 204 LILDNNELKSLP----ENLQGNIKTLYANSNQLTSIP-ATLPD--TIQEMELSINRITELPERLPS---ALQSLDLFHNK 273
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 126033176 744 IRCLTKYFLQGafqLRHLDLSSNKIqviqkTSFPENVLNNLNILFLHHN 792
Cdd:PRK15370 274 ISCLPENLPEE---LRYLSVYDNSI-----RTLPAHLPSGITHLNVQSN 314
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
372-585 |
2.94e-06 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 49.40 E-value: 2.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 372 DAFSSLKKLKVLrikgYVFKelNSLNLFP-LHNLPNLEVLDLGTNFI-KIANLsifNQFKTLKFIDLSVNKISpsgdspe 449
Cdd:cd21340 18 DNLSLCKNLKVL----YLYD--NKITKIEnLEFLTNLTHLYLQNNQIeKIENL---ENLVNLKKLYLGGNRIS------- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 450 ggfcsnrrtSVEG-HGPQVLETLHYfrydEYARscrskskeppsfLPLnedcymyGQTLDLSRNNIFFIKPSdfqhlsfL 528
Cdd:cd21340 82 ---------VVEGlENLTNLEELHI----ENQR------------LPP-------GEKLTFDPRSLAALSNS-------L 122
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 126033176 529 KCLNLSGNSISqtlNGSEFQPLVELKYLDFSNNRLDLL--YSTAFEELHNLEVLDISSN 585
Cdd:cd21340 123 RVLNISGNNID---SLEPLAPLRNLEQLDASNNQISDLeeLLDLLSSWPSLRELDLTGN 178
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
613-794 |
4.23e-06 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 50.32 E-value: 4.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 613 NYNDIATSTSRTMESESLQILEFRGNHLDILWRDGDNRYLKFFKNLLNLEELDISENSLSFLPLGVFDSMPPNLKTLSLA 692
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 693 KNGLKSFSWERLQSLKNLETLDLSF-----------------NQLKTVPERLSNCSrSLKKLILKNNQIRCLTKyFLQGA 755
Cdd:COG4886 81 LLSLLLLGLTDLGDLTNLTELDLSGneelsnltnlesldlsgNQLTDLPEELANLT-NLKELDLSNNQLTDLPE-PLGNL 158
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 126033176 756 FQLRHLDLSSNKIqviqkTSFPENV--LNNLNILFLHHNRF 794
Cdd:COG4886 159 TNLKSLDLSNNQL-----TDLPEELgnLTNLKELDLSNNQI 194
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
233-310 |
4.95e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.82 E-value: 4.95e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 126033176 233 SSLTELYLYNNIITKIQEDDFNNLSQLQVLDLSGNCPRCynvpfpctpcennsplqIDPNAFDALTELQVLRLHSNSL 310
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-----------------LSPGAFSGLPSLRYLDLSGNRL 61
|
|
| TIR_2 |
pfam13676 |
TIR domain; This is a family of Toll-like receptors. |
903-1001 |
5.28e-06 |
|
TIR domain; This is a family of Toll-like receptors.
Pssm-ID: 463954 [Multi-domain] Cd Length: 118 Bit Score: 46.54 E-value: 5.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 903 FIVYDTKDPAVTEWVLDELvakledpREKCFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFYL 982
Cdd:pfam13676 2 FISYAGEDRAWAEWLADAL-------EAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEA 74
|
90
....*....|....*....
gi 126033176 983 SHQRLMDEKvdVIILIFLE 1001
Cdd:pfam13676 75 ALADPEGRK--RLIPVRLE 91
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
577-727 |
1.16e-05 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 49.31 E-value: 1.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 577 LEVLDISSNSHYFQSEGIT------HMLNFTKNLKV-LRKLMMNYNDIAT------STSRTME-------------SESL 630
Cdd:PRK15370 185 LKILGLTTIPACIPEQITTlildnnELKSLPENLQGnIKTLYANSNQLTSipatlpDTIQEMElsinritelperlPSAL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 631 QILEFRGNHLDILwrdGDN-----RYLKFFKNLL---------NLEELDISENSLSFLPlgvfDSMPPNLKTLSLAKNGL 696
Cdd:PRK15370 265 QSLDLFHNKISCL---PENlpeelRYLSVYDNSIrtlpahlpsGITHLNVQSNSLTALP----ETLPPGLKTLEAGENAL 337
|
170 180 190
....*....|....*....|....*....|.
gi 126033176 697 KSFSWERLQSLKNletLDLSFNQLKTVPERL 727
Cdd:PRK15370 338 TSLPASLPPELQV---LDVSKNQITVLPETL 365
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
762-846 |
1.24e-05 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 49.70 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 762 DLSSNKIQVIQKTSFpeNVLNNLNILFLHHNRFLCNCDAVWFVWWVNHTEVTI--PYLAtdvTCMGPGAHKGQSVVSLDL 839
Cdd:TIGR00864 1 DISNNKISTIEEGIC--ANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqPEAA---LCAGPGALAGQPLLGIPL 75
|
....*..
gi 126033176 840 YTCELDL 846
Cdd:TIGR00864 76 LDSGCDE 82
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
528-585 |
1.43e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 43.67 E-value: 1.43e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 126033176 528 LKCLNLSGNSIsQTLNGSEFQPLVELKYLDFSNNRLDLLYSTAFEELHNLEVLDISSN 585
Cdd:pfam13855 3 LRSLDLSNNRL-TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
|
|
| LRR_12 |
pfam18837 |
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ... |
407-436 |
1.59e-05 |
|
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.
Pssm-ID: 408607 Cd Length: 30 Bit Score: 42.72 E-value: 1.59e-05
10 20 30
....*....|....*....|....*....|
gi 126033176 407 LEVLDLGTNFIKIANLSIFNQFKTLKFIDL 436
Cdd:pfam18837 1 LQTLHLQMNFINQAQLSIFGAFPGLRFVDL 30
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
212-267 |
1.62e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 43.28 E-value: 1.62e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 126033176 212 RNLKLLSLKDNNISAVPTVL---PSSLTELYLYNNIITKIQEDDFNNLSQLQVLDLSGN 267
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
621-794 |
1.84e-05 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 49.08 E-value: 1.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 621 TSRTMESESLQILEFRGNHL------DILWRDGDNRYLKFFKN----------LLNLEELDISENSLS---FLPLGVFDs 681
Cdd:PLN00113 86 SSAIFRLPYIQTINLSNNQLsgpipdDIFTTSSSLRYLNLSNNnftgsiprgsIPNLETLDLSNNMLSgeiPNDIGSFS- 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 682 mppNLKTLSLAKNGLKSFSWERLQSLKNLETLDLSFNQL-KTVPERLSNCsRSLKKLILKNNQIRCLTKYFLQGAFQLRH 760
Cdd:PLN00113 165 ---SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvGQIPRELGQM-KSLKWIYLGYNNLSGEIPYEIGGLTSLNH 240
|
170 180 190
....*....|....*....|....*....|....
gi 126033176 761 LDLSSNKIQVIQKTSFPEnvLNNLNILFLHHNRF 794
Cdd:PLN00113 241 LDLVYNNLTGPIPSSLGN--LKNLQYLFLYQNKL 272
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
507-694 |
2.14e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 46.70 E-value: 2.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 507 LDLSRNNIFFIkpSDFQHLSFLKCLNLSGNSISqTLNGSEFQP-LVELkYLdfSNNRLDLLysTAFEELHNLEVLDISSN 585
Cdd:cd21340 7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKIT-KIENLEFLTnLTHL-YL--QNNQIEKI--ENLENLVNLKKLYLGGN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 586 ShyfqsegITHMLNFTkNLKVLRKLMMNYNDIATSTS-----RTME--SESLQILEFRGNHLDilwrdgdnrYLKFFKNL 658
Cdd:cd21340 79 R-------ISVVEGLE-NLTNLEELHIENQRLPPGEKltfdpRSLAalSNSLRVLNISGNNID---------SLEPLAPL 141
|
170 180 190
....*....|....*....|....*....|....*...
gi 126033176 659 LNLEELDISENSLSFLP--LGVFDSMpPNLKTLSLAKN 694
Cdd:cd21340 142 RNLEQLDASNNQISDLEelLDLLSSW-PSLRELDLTGN 178
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
283-332 |
2.16e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 42.90 E-value: 2.16e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 126033176 283 NNSPLQIDPNAFDALTELQVLRLHSNSLQHVPQRWFKNINKLKELDLSQN 332
Cdd:pfam13855 10 NNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
217-442 |
2.26e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 46.70 E-value: 2.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 217 LSLKDNNISAVPTV-LPSSLTELYLYNNIITKIqeDDFNNLSQLQVLDLSGNCPRCynvpfpctpcennsplqIDPnaFD 295
Cdd:cd21340 7 LYLNDKNITKIDNLsLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEK-----------------IEN--LE 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 296 ALTELQVLRLHSNSLQHVPQrwFKNINKLKELDLSQNFLAKEigdakflhllhnlvnLDLSFNYDLqvyhavinlsdAFS 375
Cdd:cd21340 66 NLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPG---------------EKLTFDPRS-----------LAA 117
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 376 SLKKLKVLRIKGyvfkelNSL-NLFPLHNLPNLEVLDLGTNFIK-IANLS-IFNQFKTLKFIDLSVNKIS 442
Cdd:cd21340 118 LSNSLRVLNISG------NNIdSLEPLAPLRNLEQLDASNNQISdLEELLdLLSSWPSLRELDLTGNPVC 181
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
172-334 |
2.55e-05 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 48.54 E-value: 2.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 172 MKENLTELAnLEILYLGQNCYYRNPCNVSFTIEKDAFLNM-----RNLKLLSLKDNNISAVPTVLPSSLTELYLYNNIIT 246
Cdd:PRK15370 176 LKNNKTELR-LKILGLTTIPACIPEQITTLILDNNELKSLpenlqGNIKTLYANSNQLTSIPATLPDTIQEMELSINRIT 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 247 KIQEddfNNLSQLQVLDLSGNcprcynvPFPCTPceNNSPlqidpnafdalTELQVLRLHSNSLQHVPQRWFKNINKLKE 326
Cdd:PRK15370 255 ELPE---RLPSALQSLDLFHN-------KISCLP--ENLP-----------EELRYLSVYDNSIRTLPAHLPSGITHLNV 311
|
....*...
gi 126033176 327 LDLSQNFL 334
Cdd:PRK15370 312 QSNSLTAL 319
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
67-449 |
2.58e-05 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 48.31 E-value: 2.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 67 IPGGIPANATNLTLTINHIAGISPAsfhrldhlvEIDFRCNCVPVRLGpkDNVCTKRLqikPNSFSKLTYLKSLYLDGNQ 146
Cdd:PLN00113 134 IPRGSIPNLETLDLSNNMLSGEIPN---------DIGSFSSLKVLDLG--GNVLVGKI---PNSLTNLTSLEFLTLASNQ 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 147 LL-EIPQDlppslqllsleanniflimkenLTELANLEILYLGQNcyyrnpcNVSFTIEKDaFLNMRNLKLLSLKDNNIS 225
Cdd:PLN00113 200 LVgQIPRE----------------------LGQMKSLKWIYLGYN-------NLSGEIPYE-IGGLTSLNHLDLVYNNLT 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 226 A-VPTVLP--SSLTELYLYNNIITKIQEDDFNNLSQLQVLDLSGNCpRCYNVPFPCTPCENNSPLQI--------DPNAF 294
Cdd:PLN00113 250 GpIPSSLGnlKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNS-LSGEIPELVIQLQNLEILHLfsnnftgkIPVAL 328
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 295 DALTELQVLRLHSNSLQ-HVPQRWFKNiNKLKELDLSQNFLAKEIGDAK-----------FLHLLHNLVNLDLSF----- 357
Cdd:PLN00113 329 TSLPRLQVLQLWSNKFSgEIPKNLGKH-NNLTVLDLSTNNLTGEIPEGLcssgnlfklilFSNSLEGEIPKSLGAcrslr 407
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 358 NYDLQVYHAVINLSDAFSSLKKLKVLRIKGYVFK--------ELNSLNLFPLH------NLP------NLEVLDLGTNFI 417
Cdd:PLN00113 408 RVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgrinsrkwDMPSLQMLSLArnkffgGLPdsfgskRLENLDLSRNQF 487
|
410 420 430
....*....|....*....|....*....|..
gi 126033176 418 KIANLSIFNQFKTLKFIDLSVNKIspSGDSPE 449
Cdd:PLN00113 488 SGAVPRKLGSLSELMQLKLSENKL--SGEIPD 517
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
39-331 |
3.41e-05 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 47.77 E-value: 3.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 39 PKTLPcdvtldapNTHVIVDCTDKHLTEIPGGIPANATNLTLTINHIAGISPASFHRLDHLVEIDFRCNCVPVRLgpkdn 118
Cdd:PRK15370 236 PATLP--------DTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHL----- 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 119 vctkrlqikPNSFSKltylksLYLDGNQLLEIPQdlppslqllsleanniflimkenlTELANLEILYLGQNCYYRNPCN 198
Cdd:PRK15370 303 ---------PSGITH------LNVQSNSLTALPE------------------------TLPPGLKTLEAGENALTSLPAS 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 199 VSftiekdaflnmRNLKLLSLKDNNISAVPTVLPSSLTELYLYNNIIT----------KIQEDDFNNLSQL--QVLDLSG 266
Cdd:PRK15370 344 LP-----------PELQVLDVSKNQITVLPETLPPTITTLDVSRNALTnlpenlpaalQIMQASRNNLVRLpeSLPHFRG 412
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 126033176 267 NCPRC------YNvPFPCTPCENNSPLQID-----PNAFDALTELQVLRLhSNSLQHVPQRWfknINKLKELDLSQ 331
Cdd:PRK15370 413 EGPQPtriiveYN-PFSERTIQNMQRLMSSvgyqgPRVLFAMGDFSIVRV-TRPLHQAVQGW---LTNLEEEDVNQ 483
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
531-773 |
3.71e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 45.93 E-value: 3.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 531 LNLSGNSISQTlngSEFQPLVELKYLDFSNNRLDLLysTAFEELHNLEVLDISSNShyfqsegITHMLNFTkNLKVLRKL 610
Cdd:cd21340 7 LYLNDKNITKI---DNLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQ-------IEKIENLE-NLVNLKKL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 611 MMNYNDIATStsrtmesESLQilefrgnhldilwrdgdnrylkffkNLLNLEELDIS------ENSLSFLPLGVFdSMPP 684
Cdd:cd21340 74 YLGGNRISVV-------EGLE-------------------------NLTNLEELHIEnqrlppGEKLTFDPRSLA-ALSN 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 685 NLKTLSLAKNGLKSFSWerLQSLKNLETLDLSFNQLKtvperlsncsrSLKKLilknnqircltKYFLQGAFQLRHLDLS 764
Cdd:cd21340 121 SLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS-----------DLEEL-----------LDLLSSWPSLRELDLT 176
|
....*....
gi 126033176 765 SNKIQVIQK 773
Cdd:cd21340 177 GNPVCKKPK 185
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
74-147 |
6.48e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 41.74 E-value: 6.48e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 126033176 74 NATNLTLTINHIAGISPASFHRLDHLVEIDFRCNCVPVrlgpkdnvctkrlqIKPNSFSKLTYLKSLYLDGNQL 147
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--------------LSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
298-334 |
8.37e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 41.36 E-value: 8.37e-05
10 20 30
....*....|....*....|....*....|....*..
gi 126033176 298 TELQVLRLHSNSLQHVPQRWFKNINKLKELDLSQNFL 334
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL 37
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
732-794 |
1.17e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 40.97 E-value: 1.17e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 126033176 732 RSLKKLILKNNQIRCLTKYFLQGAFQLRHLDLSSNKIQVIQKTSFPEnvLNNLNILFLHHNRF 794
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG--LPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
544-768 |
1.65e-04 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 45.04 E-value: 1.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 544 GSEFQPLVELKYLDFSNNRLDLLYSTAFEELH---NLEVLDISSNShyfqsEGITHMLNFTKNLK----VLRKLMMNYND 616
Cdd:cd00116 74 LQGLTKGCGLQELDLSDNALGPDGCGVLESLLrssSLQELKLNNNG-----LGDRGLRLLAKGLKdlppALEKLVLGRNR 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 617 IATSTSRTMESE-----SLQILEFRGNHLdilwRDGDNRYL-KFFKNLLNLEELDISENSLsflplgvfdsMPPNLKTLS 690
Cdd:cd00116 149 LEGASCEALAKAlranrDLKELNLANNGI----GDAGIRALaEGLKANCNLEVLDLNNNGL----------TDEGASALA 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 691 laknglksfswERLQSLKNLETLDLSFNQLKTVP-----ERLSNCSRSLKKLILKNNQIRCL-TKYFLQGAFQ---LRHL 761
Cdd:cd00116 215 -----------ETLASLKSLEVLNLGDNNLTDAGaaalaSALLSPNISLLTLSLSCNDITDDgAKDLAEVLAEkesLLEL 283
|
....*..
gi 126033176 762 DLSSNKI 768
Cdd:cd00116 284 DLRGNKF 290
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
69-338 |
4.06e-04 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 44.45 E-value: 4.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 69 GGIPANATNLT------LTINHIAGISPASFHRLDHLVEIDFRCNCVPVRLgPKDNVCTKRLQIK-----------PNSF 131
Cdd:PLN00113 250 GPIPSSLGNLKnlqylfLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEI-PELVIQLQNLEILhlfsnnftgkiPVAL 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 132 SKLTYLKSLYLDGNQLL-EIPQDLPPSLQLLSLE--ANNIFLIMKENLTELANLEILYLGQNcyyrnpcnvSFTIEKDAF 208
Cdd:PLN00113 329 TSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDlsTNNLTGEIPEGLCSSGNLFKLILFSN---------SLEGEIPKS 399
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 209 LNM-RNLKLLSLKDNNISAVptvLPSSLTELYLY-------NNIITKIQEDDFNnLSQLQVLDLS-----GNCPRCynvp 275
Cdd:PLN00113 400 LGAcRSLRRVRLQDNSFSGE---LPSEFTKLPLVyfldisnNNLQGRINSRKWD-MPSLQMLSLArnkffGGLPDS---- 471
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 126033176 276 FPCTPCEN-----NSPLQIDPNAFDALTELQVLRLHSNSLQHVPQRWFKNINKLKELDLSQNFLAKEI 338
Cdd:PLN00113 472 FGSKRLENldlsrNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQI 539
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
707-793 |
5.35e-04 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 42.47 E-value: 5.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 707 LKNLETLDLSFNQLKTVPErLSNCsRSLKKLILKNNQIRCLTKyfLQGAFQLRHLDLSSNKIQVIQktsfPENVLNNLNI 786
Cdd:cd21340 1 LKRITHLYLNDKNITKIDN-LSLC-KNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE----NLENLVNLKK 72
|
....*..
gi 126033176 787 LFLHHNR 793
Cdd:cd21340 73 LYLGGNR 79
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
653-696 |
6.86e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 38.66 E-value: 6.86e-04
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 126033176 653 KFFKNLLNLEELDISENSLSFLPLGVFDSMpPNLKTLSLAKNGL 696
Cdd:pfam13855 19 GAFKGLSNLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
684-720 |
2.31e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 36.84 E-value: 2.31e-03
10 20 30
....*....|....*....|....*....|....*..
gi 126033176 684 PNLKTLSLAKNGLKSFSWerLQSLKNLETLDLSFNQL 720
Cdd:pfam12799 1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNK 35
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
52-315 |
2.67e-03 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 41.69 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 52 NTHVIVDCTDKHLTEIPGGIPANATNLTLTINHIAGIsPASFHRLDHLVEIDFRCNCVPVrLGPKdnvcTKRLQIKPNSF 131
Cdd:PRK15387 201 NGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSL-PALPPELRTLEVSGNQLTSLPV-LPPG----LLELSIFSNPL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 132 SKLTYLKS----LYLDGNQLLEIPqdlppslqllsleanniflIMKENLTELAnleilyLGQNCYYRNPCNVSFTIEKDA 207
Cdd:PRK15387 275 THLPALPSglckLWIFGNQLTSLP-------------------VLPPGLQELS------VSDNQLASLPALPSELCKLWA 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126033176 208 FLNM--------RNLKLLSLKDNNISAVPTvLPSSLTELYLYNNIITKIQEDDfnnlSQLQVLDLSGNcprcYNVPFPCT 279
Cdd:PRK15387 330 YNNQltslptlpSGLQELSVSDNQLASLPT-LPSELYKLWAYNNRLTSLPALP----SGLKELIVSGN----RLTSLPVL 400
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 126033176 280 PCENNSpLQIDPNAFDAL----TELQVLRLHSNSLQHVPQ 315
Cdd:PRK15387 401 PSELKE-LMVSGNRLTSLpmlpSGLLSLSVYRNQLTRLPE 439
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
234-267 |
8.58e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 35.30 E-value: 8.58e-03
10 20 30
....*....|....*....|....*....|....
gi 126033176 234 SLTELYLYNNIITKIqeDDFNNLSQLQVLDLSGN 267
Cdd:pfam12799 2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGN 33
|
|
| |
