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Conserved domains on  [gi|126031271]
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Chain B, T-cell surface glycoprotein CD4

Protein Classification

IgV_1_CD4 and Ig domain-containing protein( domain architecture ID 10166714)

IgV_1_CD4 and Ig domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_1_CD4 cd07690
First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of ...
 2-98 2.07e-59

First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of IgSF domains; The members here are composed of the first immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4. CD4 and CD8 are the two primary co-receptor proteins found on the surface of T cells, and the presence of either CD4 or CD8 determines the function of the T cell. CD4 is found on helper T cells, where it is required for the binding of MHC (major histocompatibility complex) class II molecules, while CD8 is found on cytotoxic T cells, where it is required for the binding of MHC class I molecules. CD4 contains four immunoglobulin domains, with the first three included in this hierarchy. The fourth domain has a general Ig architecture, but has slight topological changes in the arrangement of beta strands relative to the other structures in this family and is not specifically included in the hierarchy.


:

Pssm-ID: 409487  Cd Length: 97  Bit Score: 180.44  E-value: 2.07e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271   2 KKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSD 81
Cdd:cd07690    1 KKVVLGKKGDTAELPCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRNLWDQGSFPLIIKNLKIEDSD 80

                         90
                 ....*....|....*..
gi 126031271  82 TYICEVEDQKEEVQLLV 98
Cdd:cd07690   81 TYICEVEDKKEEVELLV 97
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 99-180 3.36e-36

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd07694:

Pssm-ID: 472250  Cd Length: 88  Bit Score: 121.25  E-value: 3.36e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271  99 FGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGG------KTLSVSQLELQDSGTWTCTVLQNQKKVEFK 172
Cdd:cd07694    1 FKLTATSSDHVLSGTNLTLTLHGSSNSLPAFKVEWRGPGNKSKQilnqdkKTLNLVQLGPNDSGTWDCIVSVNSSEKTLK 80


                 ....*...
gi 126031271 173 IDIVVLAF 180
Cdd:cd07694   81 LDIKVLAF 88
 
Name Accession Description Interval E-value
IgV_1_CD4 cd07690
First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of ...
 2-98 2.07e-59

First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of IgSF domains; The members here are composed of the first immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4. CD4 and CD8 are the two primary co-receptor proteins found on the surface of T cells, and the presence of either CD4 or CD8 determines the function of the T cell. CD4 is found on helper T cells, where it is required for the binding of MHC (major histocompatibility complex) class II molecules, while CD8 is found on cytotoxic T cells, where it is required for the binding of MHC class I molecules. CD4 contains four immunoglobulin domains, with the first three included in this hierarchy. The fourth domain has a general Ig architecture, but has slight topological changes in the arrangement of beta strands relative to the other structures in this family and is not specifically included in the hierarchy.


Pssm-ID: 409487  Cd Length: 97  Bit Score: 180.44  E-value: 2.07e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271   2 KKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSD 81
Cdd:cd07690    1 KKVVLGKKGDTAELPCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRNLWDQGSFPLIIKNLKIEDSD 80

                         90
                 ....*....|....*..
gi 126031271  82 TYICEVEDQKEEVQLLV 98
Cdd:cd07690   81 TYICEVEDKKEEVELLV 97
IgC2_2_CD4 cd07694
Second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the C2-set ...
 99-180 3.36e-36

Second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the C2-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig) Constant 2 (C2)-set domain of Cluster of Differentiation (CD) 4. CD4 and CD8 are the two primary co-receptor proteins found on the surface of T cells, and the presence of either CD4 or CD8 determines the function of the T cell. CD4 is found on helper T cells, where it is required for the binding of MHC (major histocompatibility complex) class II molecules, while CD8 is found on cytotoxic T cells, where it is required for the binding of MHC class I molecules. CD4 contains four immunoglobulin domains, with the first three included in this hierarchy. The fourth domain has a general Ig architecture, but has slight topological changes in the arrangement of beta strands relative to the other structures in this family and is not specifically included in the hierarchy. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409491  Cd Length: 88  Bit Score: 121.25  E-value: 3.36e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271  99 FGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGG------KTLSVSQLELQDSGTWTCTVLQNQKKVEFK 172
Cdd:cd07694    1 FKLTATSSDHVLSGTNLTLTLHGSSNSLPAFKVEWRGPGNKSKQilnqdkKTLNLVQLGPNDSGTWDCIVSVNSSEKTLK 80


                 ....*...
gi 126031271 173 IDIVVLAF 180
Cdd:cd07694   81 LDIKVLAF 88
C2-set pfam05790
Immunoglobulin C2-set domain;
101-179 9.78e-20

Immunoglobulin C2-set domain;


Pssm-ID: 399065  Cd Length: 80  Bit Score: 78.93  E-value: 9.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271  101 LTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVL-QNQKKVEFKIDIVVLA 179
Cdd:pfam05790   1 VTVSCSNNLLTCEVLELTLPKGSKMDPSLKLKGQEAKSLETKKLESTFQPTTEDSGTWVCLASdNDQKKLESVIEVLVLE 80
IGv smart00406
Immunoglobulin V-Type;
12-87 9.60e-12

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 58.16  E-value: 9.60e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271    12 TVELTCTASQKK--SIQFHW---KNSNQIKILGNQGSFLTK-GPSKLNDRADSRRSLwDQGNFPLIIKNLKIEDSDTYIC 85
Cdd:smart00406   1 SVTLSCKFSGSTfsSYYVSWvrqPPGKGLEWLGYIGSNGSSyYQESYKGRFTISKDT-SKNDVSLTISNLRVEDTGTYYC 79


                   ..
gi 126031271    86 EV 87
Cdd:smart00406  80 AV 81
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 1-89 1.84e-07

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 46.80  E-value: 1.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271    1 MKKVVLGKKGDTVELTCTAS-QKKSIQFHWKNSNQIKILGNQgsfltkgpsklndradSRRSLWDQGNFPLIIKNLKIED 79
Cdd:pfam00047   2 APPTVTVLEGDSATLTCSAStGSPGPDVTWSKEGGTLIESLK----------------VKHDNGRTTQSSLLISNVTKED 65

                          90
                  ....*....|
gi 126031271   80 SDTYICEVED 89
Cdd:pfam00047  66 AGTYTCVVNN 75
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 105-177 5.95e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 34.40  E-value: 5.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271   105 SDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGK-----------TLSVSQLELQDSGTWTCTVLQNQKKVEFKI 173
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVTWYKQGGKLLAESGrfsvsrsgstsTLTISNVTPEDSGTYTCAATNSSGSASSGT 81


                   ....
gi 126031271   174 DIVV 177
Cdd:smart00410  82 TLTV 85
 
Name Accession Description Interval E-value
IgV_1_CD4 cd07690
First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of ...
 2-98 2.07e-59

First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of IgSF domains; The members here are composed of the first immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4. CD4 and CD8 are the two primary co-receptor proteins found on the surface of T cells, and the presence of either CD4 or CD8 determines the function of the T cell. CD4 is found on helper T cells, where it is required for the binding of MHC (major histocompatibility complex) class II molecules, while CD8 is found on cytotoxic T cells, where it is required for the binding of MHC class I molecules. CD4 contains four immunoglobulin domains, with the first three included in this hierarchy. The fourth domain has a general Ig architecture, but has slight topological changes in the arrangement of beta strands relative to the other structures in this family and is not specifically included in the hierarchy.


Pssm-ID: 409487  Cd Length: 97  Bit Score: 180.44  E-value: 2.07e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271   2 KKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSD 81
Cdd:cd07690    1 KKVVLGKKGDTAELPCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRNLWDQGSFPLIIKNLKIEDSD 80

                         90
                 ....*....|....*..
gi 126031271  82 TYICEVEDQKEEVQLLV 98
Cdd:cd07690   81 TYICEVEDKKEEVELLV 97
IgC2_2_CD4 cd07694
Second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the C2-set ...
 99-180 3.36e-36

Second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the C2-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig) Constant 2 (C2)-set domain of Cluster of Differentiation (CD) 4. CD4 and CD8 are the two primary co-receptor proteins found on the surface of T cells, and the presence of either CD4 or CD8 determines the function of the T cell. CD4 is found on helper T cells, where it is required for the binding of MHC (major histocompatibility complex) class II molecules, while CD8 is found on cytotoxic T cells, where it is required for the binding of MHC class I molecules. CD4 contains four immunoglobulin domains, with the first three included in this hierarchy. The fourth domain has a general Ig architecture, but has slight topological changes in the arrangement of beta strands relative to the other structures in this family and is not specifically included in the hierarchy. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409491  Cd Length: 88  Bit Score: 121.25  E-value: 3.36e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271  99 FGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGG------KTLSVSQLELQDSGTWTCTVLQNQKKVEFK 172
Cdd:cd07694    1 FKLTATSSDHVLSGTNLTLTLHGSSNSLPAFKVEWRGPGNKSKQilnqdkKTLNLVQLGPNDSGTWDCIVSVNSSEKTLK 80


                 ....*...
gi 126031271 173 IDIVVLAF 180
Cdd:cd07694   81 LDIKVLAF 88
C2-set pfam05790
Immunoglobulin C2-set domain;
101-179 9.78e-20

Immunoglobulin C2-set domain;


Pssm-ID: 399065  Cd Length: 80  Bit Score: 78.93  E-value: 9.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271  101 LTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVL-QNQKKVEFKIDIVVLA 179
Cdd:pfam05790   1 VTVSCSNNLLTCEVLELTLPKGSKMDPSLKLKGQEAKSLETKKLESTFQPTTEDSGTWVCLASdNDQKKLESVIEVLVLE 80
IGv smart00406
Immunoglobulin V-Type;
12-87 9.60e-12

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 58.16  E-value: 9.60e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271    12 TVELTCTASQKK--SIQFHW---KNSNQIKILGNQGSFLTK-GPSKLNDRADSRRSLwDQGNFPLIIKNLKIEDSDTYIC 85
Cdd:smart00406   1 SVTLSCKFSGSTfsSYYVSWvrqPPGKGLEWLGYIGSNGSSyYQESYKGRFTISKDT-SKNDVSLTISNLRVEDTGTYYC 79


                   ..
gi 126031271    86 EV 87
Cdd:smart00406  80 AV 81
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 3-98 2.87e-11

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 57.13  E-value: 2.87e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271     3 KVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKgpsklndradsrrslwDQGNFPLIIKNLKIEDSDT 82
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVTWYKQGGKLLAESGRFSVSR----------------SGSTSTLTISNVTPEDSGT 65

                           90       100
                   ....*....|....*....|
gi 126031271    83 YICEVE----DQKEEVQLLV 98
Cdd:smart00410  66 YTCAATnssgSASSGTTLTV 85
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 1-89 1.84e-07

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 46.80  E-value: 1.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271    1 MKKVVLGKKGDTVELTCTAS-QKKSIQFHWKNSNQIKILGNQgsfltkgpsklndradSRRSLWDQGNFPLIIKNLKIED 79
Cdd:pfam00047   2 APPTVTVLEGDSATLTCSAStGSPGPDVTWSKEGGTLIESLK----------------VKHDNGRTTQSSLLISNVTKED 65

                          90
                  ....*....|
gi 126031271   80 SDTYICEVED 89
Cdd:pfam00047  66 AGTYTCVVNN 75
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 10-100 3.70e-06

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 43.86  E-value: 3.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271  10 GDTVELTCTASQK-KSIQFHW---KNSNQIKILGNQGSFLTKGPSKLNDRADSRRSlwDQGNFPLIIKNLKIEDSDTYIC 85
Cdd:cd00099   13 GESVTLSCEVSSSfSSTYIYWyrqKPGQGPEFLIYLSSSKGKTKGGVPGRFSGSRD--GTSSFSLTISNLQPEDSGTYYC 90

                         90
                 ....*....|....*
gi 126031271  86 EVEDQKEEVQlLVFG 100
Cdd:cd00099   91 AVSESGGTDK-LTFG 104
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 13-88 1.49e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 38.46  E-value: 1.49e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 126031271  13 VELTCTASQKKSIQFHWKnsnqikilgnqgsfltKGPSKLNDRADSRRSlWDQGNFPLIIKNLKIEDSDTYICEVE 88
Cdd:cd00096    1 VTLTCSASGNPPPTITWY----------------KNGKPLPPSSRDSRR-SELGNGTLTISNVTLEDSGTYTCVAS 59
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 5-88 2.40e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 38.32  E-value: 2.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271    5 VLGKKGDTVELTCTASQKKSIQFHWknsnqikilgnqgsflTKGPSKLNDRADSRRSLwDQGNFPLIIKNLKIEDSDTYI 84
Cdd:pfam13927  11 VTVREGETVTLTCEATGSPPPTITW----------------YKNGEPISSGSTRSRSL-SGSNSTLTISNVTRSDAGTYT 73


                  ....
gi 126031271   85 CEVE 88
Cdd:pfam13927  74 CVAS 77
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 2-95 1.04e-03

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 36.94  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271   2 KKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQiKILG--NQGSFLTKGPSKlndradsRRSLWDQGNFPLIIKNLKIED 79
Cdd:cd05775    2 SGEVYGALGGNVTLTISSLQDDIDEIKWKKTKD-KIVEweNNIGPTYFGSFK-------DRVLLDKESGSLTIKNLTKED 73

                         90
                 ....*....|....*.
gi 126031271  80 SDTYICEVEDQKEEVQ 95
Cdd:cd05775   74 SGTYELEITSTNGKVL 89
I-set pfam07679
Immunoglobulin I-set domain;
3-98 1.08e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 36.47  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271    3 KVVLGKKGDTVELTCTASQKKSIQFHWknsnqikilgnqgsflTKGPSKLndRADSRRSL-WDQGNFPLIIKNLKIEDSD 81
Cdd:pfam07679   8 KDVEVQEGESARFTCTVTGTPDPEVSW----------------FKDGQPL--RSSDRFKVtYEGGTYTLTISNVQPDDSG 69

                          90       100
                  ....*....|....*....|.
gi 126031271   82 TYICEVED----QKEEVQLLV 98
Cdd:pfam07679  70 KYTCVATNsageAEASAELTV 90
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 105-177 1.90e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 35.83  E-value: 1.90e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 126031271  105 SDTHLLQGQSLTLTLESPPGSSPSVQCRSPrGKNIQGGKTLSVSQLELQDSGTWTCTV-LQNQKKVEFKIDIVV 177
Cdd:pfam13895   7 SPTVVTEGEPVTLTCSAPGNPPPSYTWYKD-GSAISSSPNFFTLSVSAEDSGTYTCVArNGRGGKVSNPVELTV 79
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 10-100 1.91e-03

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 36.48  E-value: 1.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271  10 GDTVELTCTASQKKSIQFHWknsnqIKILGNQG-SFLTKGPSKLNDRADSRRSLW---DQGNFPLIIKNLKIEDSDTYIC 85
Cdd:cd04983   13 GENVTLNCNYSTSTFYYLFW-----YRQYPGQGpQFLIYISSDSGNKKKGRFSATldkSRKSSSLHISAAQLSDSAVYFC 87

                         90
                 ....*....|....*
gi 126031271  86 EVEDQkEEVQLLVFG 100
Cdd:cd04983   88 ALSES-GGTGKLTFG 101
Receptor_2B4 pfam11465
Natural killer cell receptor 2B4; 2B4 is a transmembrane receptor which is expressed primarily ...
 5-99 3.48e-03

Natural killer cell receptor 2B4; 2B4 is a transmembrane receptor which is expressed primarily on natural killer cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function.


Pssm-ID: 288342  Cd Length: 108  Bit Score: 35.71  E-value: 3.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271    5 VLGKKGDTVELTCTASQKKSIQFHWKNSNQikilGNQG-----SFLTKGPSKLNDRADSRRSlWDQGNFPLIIKNLKIED 79
Cdd:pfam11465   8 VVGVSGKPVQLRPSNIQTKVVSIAWKKLLP----SHNGfhhilKWENGSLPSNNMCSSDIYG-FIVKNFALSIKSAKLQD 82

                          90       100
                  ....*....|....*....|....*
gi 126031271   80 SDTYICEVEDQKEEV-----QLLVF 99
Cdd:pfam11465  83 SGHYLLEITNISGKVctknfQVLIF 107
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 3-87 5.14e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 35.13  E-value: 5.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271    3 KVVLGKKGDTVELTCTAS---QKKSIQFHW-----KNSNQIKILGnqgsFLTKGPSKLNDRADSRRSLWDQGNFPLIIKN 74
Cdd:pfam07686   4 REVTVALGGSVTLPCTYSssmSEASTSVYWyrqppGKGPTFLIAY----YSNGSEEGVKKGRFSGRGDPSNGDGSLTIQN 79

                          90
                  ....*....|...
gi 126031271   75 LKIEDSDTYICEV 87
Cdd:pfam07686  80 LTLSDSGTYTCAV 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 105-177 5.95e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 34.40  E-value: 5.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271   105 SDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGK-----------TLSVSQLELQDSGTWTCTVLQNQKKVEFKI 173
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVTWYKQGGKLLAESGrfsvsrsgstsTLTISNVTPEDSGTYTCAATNSSGSASSGT 81


                   ....
gi 126031271   174 DIVV 177
Cdd:smart00410  82 TLTV 85
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 3-89 8.06e-03

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 34.30  E-value: 8.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126031271   3 KVVLGKKGDTVELTCtasqkksiQFHWKNSNQIKILGNQGSFL-TKGPSKLNDRADSRRSLWDQ---GNFPLIIKNLKIE 78
Cdd:cd05716    5 EVVTGVEGGSVTIQC--------PYPPKYASSRKYWCKWGSEGcQTLVSSEGVVPGGRISLTDDpdnGVFTVTLNQLRKE 76

                         90
                 ....*....|.
gi 126031271  79 DSDTYICEVED 89
Cdd:cd05716   77 DAGWYWCGVGD 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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