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Conserved domains on  [gi|1247148360|ref|XP_022456600|]
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uncharacterized protein KUCA_T00000549001 [Kuraishia capsulata CBS 1993]

Protein Classification

electron transfer flavoprotein regulatory factor 1( domain architecture ID 14448812)

electron transfer flavoprotein regulatory factor 1 (ETFRF1) acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB)

Gene Ontology:  GO:0022904

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Complex1_LYR_ETFRF1_LYRM5 cd20265
LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory ...
 2-74 2.48e-28

LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins; ETFRF1, also called LYR motif-containing protein 5 (LYRM5), or Ghiso (growth-factor inducible soluble) factor, acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). It belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


:

Pssm-ID: 380760  Cd Length: 74  Bit Score: 96.50  E-value: 2.48e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1247148360  2 NPKVRQLYKDLLWLAKNYPGDYPKIRDKLHDGFIRNARVSSGEELEKCLEHGEFIAKELQSLYFLRTYRAVKR 74
Cdd:cd20265    1 RSRVRQLYKRLLYLGRDYPGGLDYFRDRLKRAFMKNKDLTDPEEIKKAIARGEYVIKELEALYSLRKYRALKK 73
 
Name Accession Description Interval E-value
Complex1_LYR_ETFRF1_LYRM5 cd20265
LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory ...
 2-74 2.48e-28

LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins; ETFRF1, also called LYR motif-containing protein 5 (LYRM5), or Ghiso (growth-factor inducible soluble) factor, acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). It belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380760  Cd Length: 74  Bit Score: 96.50  E-value: 2.48e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1247148360  2 NPKVRQLYKDLLWLAKNYPGDYPKIRDKLHDGFIRNARVSSGEELEKCLEHGEFIAKELQSLYFLRTYRAVKR 74
Cdd:cd20265    1 RSRVRQLYKRLLYLGRDYPGGLDYFRDRLKRAFMKNKDLTDPEEIKKAIARGEYVIKELEALYSLRKYRALKK 73
Complex1_LYR_2 pfam13233
Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, ...
 5-61 1.22e-05

Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, pfam05347, likely to be involved in Fe-S cluster biogenesis in mitochondria.


Pssm-ID: 463812  Cd Length: 79  Bit Score: 39.25  E-value: 1.22e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 1247148360  5 VRQLYKDLLWLAKNYPGD-YPKIRDKLHDGFIRNARVSSGEELEKCLEHGEFIAKELQ 61
Cdd:pfam13233  1 VLSLYRALLRELRELPPNgRSYGRQYLRAEFRRHKHLTDPEEIAEFLKSWREYKELLE 58
 
Name Accession Description Interval E-value
Complex1_LYR_ETFRF1_LYRM5 cd20265
LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory ...
 2-74 2.48e-28

LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins; ETFRF1, also called LYR motif-containing protein 5 (LYRM5), or Ghiso (growth-factor inducible soluble) factor, acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). It belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380760  Cd Length: 74  Bit Score: 96.50  E-value: 2.48e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1247148360  2 NPKVRQLYKDLLWLAKNYPGDYPKIRDKLHDGFIRNARVSSGEELEKCLEHGEFIAKELQSLYFLRTYRAVKR 74
Cdd:cd20265    1 RSRVRQLYKRLLYLGRDYPGGLDYFRDRLKRAFMKNKDLTDPEEIKKAIARGEYVIKELEALYSLRKYRALKK 73
Complex1_LYR_2 pfam13233
Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, ...
 5-61 1.22e-05

Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, pfam05347, likely to be involved in Fe-S cluster biogenesis in mitochondria.


Pssm-ID: 463812  Cd Length: 79  Bit Score: 39.25  E-value: 1.22e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 1247148360  5 VRQLYKDLLWLAKNYPGD-YPKIRDKLHDGFIRNARVSSGEELEKCLEHGEFIAKELQ 61
Cdd:pfam13233  1 VLSLYRALLRELRELPPNgRSYGRQYLRAEFRRHKHLTDPEEIAEFLKSWREYKELLE 58
Complex1_LYR_LYRM1 cd20261
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and ...
 4-54 5.71e-03

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins; LYR motif-containing protein 1 (LYRM1) may promote cell proliferation and inhibition of apoptosis of preadipocytes. Overexpression of the human LYRM1 causes mitochondrial dysfunction and induces insulin resistance in 3T3-L1 adipocytes. LYRM1 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380756  Cd Length: 70  Bit Score: 32.21  E-value: 5.71e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 1247148360  4 KVRQLYKDLLWLAKNYPGDYPK----IRDKLHDGFIRNARVSSGEELEKCLEHGE 54
Cdd:cd20261    1 EVLSLYRRILRLARTWPADTEEereyILNEARSLFRKNKNLTDPEEIEEKIQEAE 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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