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Conserved domains on  [gi|124512998|ref|XP_001349855|]
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conserved Plasmodium protein, unknown function [Plasmodium falciparum 3D7]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PBP_sp32 super family cl06315
Proacrosin binding protein sp32; This family consists of several mammalian specific proacrosin ...
 1261-1309 1.75e-07

Proacrosin binding protein sp32; This family consists of several mammalian specific proacrosin binding protein sp32 sequences. sp32 is a sperm specific protein which is known to bind with with 55- and 53-kDa proacrosins and the 49-kDa acrosin intermediate. The exact function of sp32 is unclear, it is thought however that the binding of sp32 to proacrosin may be involved in packaging the acrosin zymogen into the acrosomal matrix.


The actual alignment was detected with superfamily member pfam07222:

Pssm-ID: 429354  Cd Length: 243  Bit Score: 54.84  E-value: 1.75e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 124512998  1261 GKKEQKNE--PKQEQKKEPKQEPKQEPKQEQKYEQKQEQKHEQKHEQKHEQ 1309
Cdd:pfam07222  187 GGKDQAPErrHGQEQGVEHKQEPIQEHKLEEAQEQEEQEEEEEEEEAKQEE 237
 
Name Accession Description Interval E-value
PBP_sp32 pfam07222
Proacrosin binding protein sp32; This family consists of several mammalian specific proacrosin ...
 1261-1309 1.75e-07

Proacrosin binding protein sp32; This family consists of several mammalian specific proacrosin binding protein sp32 sequences. sp32 is a sperm specific protein which is known to bind with with 55- and 53-kDa proacrosins and the 49-kDa acrosin intermediate. The exact function of sp32 is unclear, it is thought however that the binding of sp32 to proacrosin may be involved in packaging the acrosin zymogen into the acrosomal matrix.


Pssm-ID: 429354  Cd Length: 243  Bit Score: 54.84  E-value: 1.75e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 124512998  1261 GKKEQKNE--PKQEQKKEPKQEPKQEPKQEQKYEQKQEQKHEQKHEQKHEQ 1309
Cdd:pfam07222  187 GGKDQAPErrHGQEQGVEHKQEPIQEHKLEEAQEQEEQEEEEEEEEAKQEE 237
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1245-1318 2.47e-05

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 49.03  E-value: 2.47e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124512998 1245 NRIDEDttKKDQTydkgKKEQKNEPKQEQKKEPKQEPKQEPKQEQKYEQKQEQKHEQKHEQKHEQKHEQKIDQK 1318
Cdd:PRK09510   65 NRQQQQ--QKSAK----RAEEQRKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAALKQK 132
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1258-1323 5.03e-05

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 47.92  E-value: 5.03e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124512998  1258 YDKGKKEQK-NEPKQEQKKEPKQEPKQEPKQEQKYEQ-KQEQKHEQKHEQKHEQKheqKIDQKLMKKP 1323
Cdd:TIGR02794   43 VDPGAVAQQaNRIQQQKKPAAKKEQERQKKLEQQAEEaEKQRAAEQARQKELEQR---AAAEKAAKQA 107
 
Name Accession Description Interval E-value
PBP_sp32 pfam07222
Proacrosin binding protein sp32; This family consists of several mammalian specific proacrosin ...
 1261-1309 1.75e-07

Proacrosin binding protein sp32; This family consists of several mammalian specific proacrosin binding protein sp32 sequences. sp32 is a sperm specific protein which is known to bind with with 55- and 53-kDa proacrosins and the 49-kDa acrosin intermediate. The exact function of sp32 is unclear, it is thought however that the binding of sp32 to proacrosin may be involved in packaging the acrosin zymogen into the acrosomal matrix.


Pssm-ID: 429354  Cd Length: 243  Bit Score: 54.84  E-value: 1.75e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 124512998  1261 GKKEQKNE--PKQEQKKEPKQEPKQEPKQEQKYEQKQEQKHEQKHEQKHEQ 1309
Cdd:pfam07222  187 GGKDQAPErrHGQEQGVEHKQEPIQEHKLEEAQEQEEQEEEEEEEEAKQEE 237
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1245-1318 2.47e-05

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 49.03  E-value: 2.47e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124512998 1245 NRIDEDttKKDQTydkgKKEQKNEPKQEQKKEPKQEPKQEPKQEQKYEQKQEQKHEQKHEQKHEQKHEQKIDQK 1318
Cdd:PRK09510   65 NRQQQQ--QKSAK----RAEEQRKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAALKQK 132
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1258-1323 5.03e-05

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 47.92  E-value: 5.03e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124512998  1258 YDKGKKEQK-NEPKQEQKKEPKQEPKQEPKQEQKYEQ-KQEQKHEQKHEQKHEQKheqKIDQKLMKKP 1323
Cdd:TIGR02794   43 VDPGAVAQQaNRIQQQKKPAAKKEQERQKKLEQQAEEaEKQRAAEQARQKELEQR---AAAEKAAKQA 107
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1250-1318 7.62e-05

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 47.49  E-value: 7.62e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512998 1250 DTTKKDQTYDKGKKEQKNEPKQEQKKEPKQEPK-QEPKQEQKYEQKQEQKHEQKHEQKHEQKhEQKIDQK 1318
Cdd:PRK09510   56 DPGAVVEQYNRQQQQQKSAKRAEEQRKKKEQQQaEELQQKQAAEQERLKQLEKERLAAQEQK-KQAEEAA 124
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1250-1324 1.00e-04

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 47.15  E-value: 1.00e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124512998  1250 DTTKKDQTYDKGKKEQKNEPKQEQKKEPK-QEPKQEPKQEQKYEQKQEQKHEQKHEQKHEQKHEQKIDQKLMKKPK 1324
Cdd:TIGR02794   44 DPGAVAQQANRIQQQKKPAAKKEQERQKKlEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQK 119
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1249-1324 1.91e-04

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 45.99  E-value: 1.91e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124512998  1249 EDTTKKDQTYDKGKKEQKNEPKQEQKKEPKQEPKQEPKQEQKYEQKQEQKHEQKHEQKHEQKHEQKIDQKLMKKPK 1324
Cdd:TIGR02794   60 KPAAKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKAKQAAEAKAK 135
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1243-1319 1.59e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 43.26  E-value: 1.59e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124512998 1243 DNNRIDEDTTKKDQTYDKGKKEQKNEPKQEQKKEPKQEPKQEPKQEQKYEQKQEQKHEQKheQKHEQKHEQKIDQKL 1319
Cdd:PRK09510   73 SAKRAEEQRKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAALKQK--QAEEAAAKAAAAAKA 147
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1253-1323 2.08e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 42.91  E-value: 2.08e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124512998  1253 KKDQTYDKGKKEQKNEPKQEQKKEPKQEPKQEpKQEQKYEQKQEQKHEQKheQKHEQKHEQKIDQKLMKKP 1323
Cdd:TIGR02794   85 AAEQARQKELEQRAAAEKAAKQAEQAAKQAEE-KQKQAEEAKAKQAAEAK--AKAEAEAERKAKEEAAKQA 152
PKK pfam12474
Polo kinase kinase; This domain family is found in eukaryotes, and is approximately 140 amino ...
 1244-1314 7.66e-03

Polo kinase kinase; This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with pfam00069. Polo-like kinase 1 (Plx1) is essential during mitosis for the activation of Cdc25C, for spindle assembly, and for cyclin B degradation. This family is Polo kinase kinase (PKK) which phosphorylates Polo kinase and Polo-like kinase to activate them. PKK is a serine/threonine kinase.


Pssm-ID: 463600 [Multi-domain]  Cd Length: 139  Bit Score: 39.08  E-value: 7.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124512998  1244 NNRIDEDTTKKDQTYDKG------KKEQKNEPKQ------EQKKEPKQEPKQEPKQEQKYEQKQeQKHEQKHEQKHEQKH 1311
Cdd:pfam12474   33 QQKQQIEKLEQRQTQELRrlpkriRAEQKKRLKMfreslkQEKKELKQEVEKLPKFQRKEAKRQ-RKEELELEQKHEELE 111


                   ...
gi 124512998  1312 EQK 1314
Cdd:pfam12474  112 FLQ 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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