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Conserved domains on  [gi|1244552260|gb|ATD52774|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Thylacinus cynocephalus]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-165 1.09e-69

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 208.50  E-value: 1.09e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552260   1 MKMMVIFLLSLMLVMGFVAFASKPSPVYGGLSLVISGGIGCGIVVSLGNVFLGLIVFLIYLGGMLVVFGYTAAMATEEYP 80
Cdd:MTH00109    1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552260  81 ESWVGNLVAFSMLVFAFLTELLWYMM---SGEILAVYNME------LLDSLGNYCVGQDWNGVSWLYGCGGWALVLLGWV 151
Cdd:MTH00109   81 ETWVSNKVVLGALLLGLLMELLLVLYvlkDDEVEVVFNFNglgdwvIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                         170
                  ....*....|....
gi 1244552260 152 LFMTILVILEIVRG 165
Cdd:MTH00109  161 LFIGVFVIIEITRG 174
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-165 1.09e-69

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 208.50  E-value: 1.09e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552260   1 MKMMVIFLLSLMLVMGFVAFASKPSPVYGGLSLVISGGIGCGIVVSLGNVFLGLIVFLIYLGGMLVVFGYTAAMATEEYP 80
Cdd:MTH00109    1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552260  81 ESWVGNLVAFSMLVFAFLTELLWYMM---SGEILAVYNME------LLDSLGNYCVGQDWNGVSWLYGCGGWALVLLGWV 151
Cdd:MTH00109   81 ETWVSNKVVLGALLLGLLMELLLVLYvlkDDEVEVVFNFNglgdwvIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                         170
                  ....*....|....
gi 1244552260 152 LFMTILVILEIVRG 165
Cdd:MTH00109  161 LFIGVFVIIEITRG 174
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
18-162 2.79e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 52.51  E-value: 2.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552260  18 VAFASKPSPVYGGLSLVISGGIGCGIVVSLGNVFLGLIVFLIYLGGMLVVFGYTAAM-ATEEYPESWVGNLVAFSMLVFA 96
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1244552260  97 FLTELLWYMMSGEILAVYNMELLDSLGNycvgQDWNGVSwLYGCGGWALVLLGWVLFMTILVILEI 162
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAAAAAAPDVGN----IEAIGEL-LFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-165 1.09e-69

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 208.50  E-value: 1.09e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552260   1 MKMMVIFLLSLMLVMGFVAFASKPSPVYGGLSLVISGGIGCGIVVSLGNVFLGLIVFLIYLGGMLVVFGYTAAMATEEYP 80
Cdd:MTH00109    1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552260  81 ESWVGNLVAFSMLVFAFLTELLWYMM---SGEILAVYNME------LLDSLGNYCVGQDWNGVSWLYGCGGWALVLLGWV 151
Cdd:MTH00109   81 ETWVSNKVVLGALLLGLLMELLLVLYvlkDDEVEVVFNFNglgdwvIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                         170
                  ....*....|....
gi 1244552260 152 LFMTILVILEIVRG 165
Cdd:MTH00109  161 LFIGVFVIIEITRG 174
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 3-166 1.73e-37

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 126.50  E-value: 1.73e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552260   3 MMVIFLLSLMLVMGFVAFASKPSPVYGGLSLVISGGIGCGIVVSLGNVFLGLIVFLIYLGGMLVVFGYTAAMATEEYPES 82
Cdd:MTH00065    2 MYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPEA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552260  83 WvGNLVAFSMLVFAFLTELLWYMMSGEILAVYNMELLDSLGNYCVGQDWNGVSWLYGCGGWALVLLGWVLFMTILVILEI 162
Cdd:MTH00065   82 W-GSWSVLVYVLFYLLLLIVGYILFGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVLLLTLFVVLEV 160


                  ....
gi 1244552260 163 VRGL 166
Cdd:MTH00065  161 TRGL 164
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 3-166 4.25e-37

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 125.64  E-value: 4.25e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552260   3 MMVIFLLSLMLVMGFVAFASKPSPVYGGLSLVISGGIGCGIVVSLGNVFLGLIVFLIYLGGMLVVFGYTAAMATEEYPES 82
Cdd:MTH00138    2 TYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPES 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552260  83 WVGNLVAFSMLVFAFLTELLWYMMSGEILAVYnMELLDSLGNYCVGQ-DWNGVSWLYGCGGWALVLLGWVLFMTILVILE 161
Cdd:MTH00138   82 WGSWSVLGYVVGYLVGVVLAAGLFWGGWYEGS-WVVVDELKEFSVLRgDVGGVALMYSSGGGMLVICAWVLLLTLFVVLE 160


                  ....*
gi 1244552260 162 IVRGL 166
Cdd:MTH00138  161 LTRGL 165
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 3-166 1.44e-29

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 106.37  E-value: 1.44e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552260   3 MMVIFLLSLMLVMGFVAFASKPSPVYGGLSLVISGGIGCGIVVSLGNVFLGLIVFLIYLGGMLVVFGYTAAMATEEYPES 82
Cdd:MTH00115    2 MYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPEA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552260  83 WVGNLVAFSMLVFAFLTELLWYMMSGEI-LAVYNMELLDSLGNYCVGQDWNGVSWLYGCGGWALVLLGWVLFMTILVILE 161
Cdd:MTH00115   82 WGDWGVVGYVVGFVLVVVVVGVVVGGLWgMEGVGVVTVDSGGLFVVRLDFSGVSLFYSSGGGGLLVCGWGLLLTLFVVLE 161


                  ....*
gi 1244552260 162 IVRGL 166
Cdd:MTH00115  162 LVRGL 166
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 3-166 8.21e-20

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 80.80  E-value: 8.21e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552260   3 MMVIFLLSLMLVMGFVAFASKPSPVYGGLSLVISGGIGCGIVVSLGNVFLGLIVFLIYLGGMLVVFGYTAAMATEEYPES 82
Cdd:MTH00214    2 LYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPES 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552260  83 WVGNLVAFSMLVFAFLTELLWYMMSGEILAVYNMELLdslgnYCVGQDWNGVSWLYGCGGWALVLLGWVLFMTILVILEI 162
Cdd:MTH00214   82 WGGWSVLLFFLFYLLGLGFVGFYFYGGWEMLSWMGVD-----EANNLDLSGVSDLYSRGFFLLLLGGVVLFLVLFVVLEL 156


                  ....
gi 1244552260 163 VRGL 166
Cdd:MTH00214  157 VRGL 160
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 3-165 2.58e-11

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 58.38  E-value: 2.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552260   3 MMVIFLLSLMLVMGFVAFASKpSPVYGGLSLVISGGIGCGIVVSLGNVFLGLIVFLIYLGGMLVVFGYTAAMATEEYPEs 82
Cdd:MTH00045    1 MVFYLFLILMLFGSTLVFYSL-SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPS- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552260  83 wVGNLVAFSMLVFAFlteLLWYMMSGEILavynMELLDSLGNYCVGQDWNGVSWLYGCGGWALVLLGWVLFMTILVILEI 162
Cdd:MTH00045   79 -VSNLGEVLVLSLLL---SLWVFISFDNF----LELSNNNWSLVSLSDLVGSSELYNSGGLYLLLGGFILLVALVVALVI 150


                  ...
gi 1244552260 163 VRG 165
Cdd:MTH00045  151 SFG 153
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
18-162 2.79e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 52.51  E-value: 2.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552260  18 VAFASKPSPVYGGLSLVISGGIGCGIVVSLGNVFLGLIVFLIYLGGMLVVFGYTAAM-ATEEYPESWVGNLVAFSMLVFA 96
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1244552260  97 FLTELLWYMMSGEILAVYNMELLDSLGNycvgQDWNGVSwLYGCGGWALVLLGWVLFMTILVILEI 162
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAAAAAAPDVGN----IEAIGEL-LFTDYLLPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 3-79 2.26e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 39.60  E-value: 2.26e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1244552260   3 MMVIFLLSLMLVMGFvAFASKPSPVYGGLSLVISGGIGCGIVVSLGNVFLGLIVFLIYLGGMLVVFGYTAAMATEEY 79
Cdd:MTH00212    1 MLLSLLLSLLLLLML-LFPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 4-107 1.86e-03

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 36.79  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552260   4 MVIFLLSLMLVMGFVAFASKPSPVYGGLSLVISGGIGCGIVVSLGNVFLGLIVFLIYLGGMLVVFGYTAAMATeEYPESW 83
Cdd:MTH00152    1 MSLMILLSVCFSLFLLLPLSKQPLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLSP-NPLFGS 79

                          90       100
                  ....*....|....*....|....
gi 1244552260  84 VGNLVAFSMLVFAFLTELLWYMMS 107
Cdd:MTH00152   80 NFKFVFFSLTLFGFLGLFFFFLYL 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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