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Conserved domains on  [gi|124375892|gb|AAI32782|]
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Zinc finger protein 2 homolog (mouse) [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
99-451 3.10e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 3.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892  99 KKIYECNQCSKTFSQSSSLLKHQRIHTGEKPYKCNV--CGKHFIERSSLTVHQRIHTGEKPYKC---------------- 160
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskslplsnskassssl 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 161 NECGKAF-----SQSMNLTVHQR---THTGEKPYQCKEC---------------------------GKAFHKNSSLIQHE 205
Cdd:COG5048  111 SSSSSNSndnnlLSSHSLPPSSRdpqLPDLLSISNLRNNplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 206 RIHTGEKPYKCNECGKAFTQSMNLTVHQRTHTGEKPYECNECGKAFSQS------MHLIVHQRSHTGEKPYECSQCGKAF 279
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 280 SKSSTLTLHQRNHTG-EKPYKCNKCGKSFSQSTYLIEHQRLHS----GVKPFECNE--CGKAFSKNSSLTQHRRIHTGEK 352
Cdd:COG5048  271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNhsgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 353 PYECM--VCGKHFTGRS-----SLTVHQVIHTGEKPYEC--NECGKAFSQSAYLIEHQRIHTGEKPYECD--QCGKAFIK 421
Cdd:COG5048  351 PAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                        410       420       430
                 ....*....|....*....|....*....|
gi 124375892 422 NSSLTVHQRTHTGEKPYQCNECGKAFSRST 451
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
99-451 3.10e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 3.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892  99 KKIYECNQCSKTFSQSSSLLKHQRIHTGEKPYKCNV--CGKHFIERSSLTVHQRIHTGEKPYKC---------------- 160
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskslplsnskassssl 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 161 NECGKAF-----SQSMNLTVHQR---THTGEKPYQCKEC---------------------------GKAFHKNSSLIQHE 205
Cdd:COG5048  111 SSSSSNSndnnlLSSHSLPPSSRdpqLPDLLSISNLRNNplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 206 RIHTGEKPYKCNECGKAFTQSMNLTVHQRTHTGEKPYECNECGKAFSQS------MHLIVHQRSHTGEKPYECSQCGKAF 279
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 280 SKSSTLTLHQRNHTG-EKPYKCNKCGKSFSQSTYLIEHQRLHS----GVKPFECNE--CGKAFSKNSSLTQHRRIHTGEK 352
Cdd:COG5048  271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNhsgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 353 PYECM--VCGKHFTGRS-----SLTVHQVIHTGEKPYEC--NECGKAFSQSAYLIEHQRIHTGEKPYECD--QCGKAFIK 421
Cdd:COG5048  351 PAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                        410       420       430
                 ....*....|....*....|....*....|
gi 124375892 422 NSSLTVHQRTHTGEKPYQCNECGKAFSRST 451
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
200-225 1.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.95e-04
                          10        20
                  ....*....|....*....|....*.
gi 124375892  200 SLIQHERIHTGEKPYKCNECGKAFTQ 225
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 184-232 2.35e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 2.35e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124375892 184 KPYqCKECGKAFHKNSSLIQHERIHTgekpYKCNECGKAFTQSMNLTVH 232
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 132-263 6.63e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 39.08  E-value: 6.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 132 CNVCgKHFIERSSLTVHQ-------------------RIHTGEKPYKCNECGKAFSQSmNLTVHQRTHtgEKPYQCKeCG 192
Cdd:PLN03086 410 CRNC-KHYIPSRSIALHEaycsrhnvvcphdgcgivlRVEEAKNHVHCEKCGQAFQQG-EMEKHMKVF--HEPLQCP-CG 484

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 193 KAFHKNsSLIQHERIHTGEKPYKCNECG---KAFTQSM-------NLTVHQRThTGEKPYECNECGKAF---SQSMHLI- 258
Cdd:PLN03086 485 VVLEKE-QMVQHQASTCPLRLITCRFCGdmvQAGGSAMdvrdrlrGMSEHESI-CGSRTAPCDSCGRSVmlkEMDIHQIa 562


                 ....*
gi 124375892 259 VHQRS 263
Cdd:PLN03086 563 VHQKS 567
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
99-451 3.10e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 3.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892  99 KKIYECNQCSKTFSQSSSLLKHQRIHTGEKPYKCNV--CGKHFIERSSLTVHQRIHTGEKPYKC---------------- 160
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskslplsnskassssl 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 161 NECGKAF-----SQSMNLTVHQR---THTGEKPYQCKEC---------------------------GKAFHKNSSLIQHE 205
Cdd:COG5048  111 SSSSSNSndnnlLSSHSLPPSSRdpqLPDLLSISNLRNNplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 206 RIHTGEKPYKCNECGKAFTQSMNLTVHQRTHTGEKPYECNECGKAFSQS------MHLIVHQRSHTGEKPYECSQCGKAF 279
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 280 SKSSTLTLHQRNHTG-EKPYKCNKCGKSFSQSTYLIEHQRLHS----GVKPFECNE--CGKAFSKNSSLTQHRRIHTGEK 352
Cdd:COG5048  271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNhsgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 353 PYECM--VCGKHFTGRS-----SLTVHQVIHTGEKPYEC--NECGKAFSQSAYLIEHQRIHTGEKPYECD--QCGKAFIK 421
Cdd:COG5048  351 PAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                        410       420       430
                 ....*....|....*....|....*....|
gi 124375892 422 NSSLTVHQRTHTGEKPYQCNECGKAFSRST 451
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
128-461 4.75e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 4.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 128 KPYKCNVCGKHFIERSSLTVHQRIHTGEKPYKCN--ECGKAFSQSMNLTVHQRTHTGEKPY-QCKECGKAFHKNSSLIQH 204
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 205 ERIHTGEKPYKCNECGKAFTQ--SMNLTVHQRTHTGEKPYE-CNECGKAFSQS--MHLIVHQRSHTGEKpyecsqcgkaf 279
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSrdPQLPDLLSISNLRNNPLPgNNSSSVNTPQSnsLHPPLPANSLSKDP----------- 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 280 SKSSTLTLHQRNHTGEKPYKCNKCGKSFSQSTYLIEHQRLHSGVKPFECNECGKAFSK------NSSLTQHRRIHTGEKP 353
Cdd:COG5048  181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASES 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 354 YECMVCGKHFTGRSSLTVHQVIHTG-EKPYECNECGKAFSQSAYLIEHQR--IHTGEkpyecdqcgkafiknssltvhqr 430
Cdd:COG5048  261 PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGE----------------------- 317

                        330       340       350
                 ....*....|....*....|....*....|...
gi 124375892 431 thtGEKPYQCNE--CGKAFSRSTNLTRHQRTHT 461
Cdd:COG5048  318 ---SLKPFSCPYslCGKLFSRNDALKRHILLHT 347
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-460 5.66e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 5.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 156 KPYKCNECGKAFSQSMNLTVHQRTHTGEKPYQC--KECGKAFHKNSSLIQHERIHTGEKPYKC----------------N 217
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskslplsnskasssslS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 218 ECGKAF---TQSMNLTVHQRTHTGEKPYECNEC--GKAFSQSMHLIVHQRSHTGEKPYECSQ--CGKAFSKSSTLTLHQR 290
Cdd:COG5048  112 SSSSNSndnNLLSSHSLPPSSRDPQLPDLLSISnlRNNPLPGNNSSSVNTPQSNSLHPPLPAnsLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 291 NHTGEKPYKCNKCGKSFSQSTYLIEHQRLHSGVKPFECNECGKAFSK------NSSLTQHRRIHTGEKPYECMVCGKHFT 364
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 365 GRSSLTVHQVIHTG-EKPYECNECGKAFSQSAYLIEHQR--IHTGE--KPYECD--QCGKAFIKNSSLTVHQRTHTGEKP 437
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISP 351

                        330       340
                 ....*....|....*....|....*
gi 124375892 438 YQC--NECGKAFSRSTNLTRHQRTH 460
Cdd:COG5048  352 AKEklLNSSSKFSPLLNNEPPQSLQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
71-336 3.18e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 3.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892  71 KRPHNCNSHGEDATQNSELIKTQRMFVGKKIYECNQCSKTFSQSSSllkhqriHTGEKPYKCNVCGKHFIERSSLTVHQR 150
Cdd:COG5048  209 YSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS-------SSASESPRSSLPTASSQSSSPNESDSS 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 151 IHTG-EKPYKCNECGKAFSQSMNLTVHQRT--HTGE--KPYQCKE--CGKAFHKNSSLIQHERIHTGEKPYKCNecgkaf 223
Cdd:COG5048  282 SEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK------ 355

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 224 tqsmnLTVHQRTHTGEKPYECNECgkafsqsmhlIVHQRSHTGEKPYEC--SQCGKAFSKSSTLTLHQRNHTGEKP--YK 299
Cdd:COG5048  356 -----LLNSSSKFSPLLNNEPPQS----------LQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 124375892 300 CNKCGKSFSQSTYLIEHQRLHSGVKPFECNECGKAFS 336
Cdd:COG5048  421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
200-225 1.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.95e-04
                          10        20
                  ....*....|....*....|....*.
gi 124375892  200 SLIQHERIHTGEKPYKCNECGKAFTQ 225
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
228-253 2.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.35e-04
                          10        20
                  ....*....|....*....|....*.
gi 124375892  228 NLTVHQRTHTGEKPYECNECGKAFSQ 253
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
144-169 3.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.81e-04
                          10        20
                  ....*....|....*....|....*.
gi 124375892  144 SLTVHQRIHTGEKPYKCNECGKAFSQ 169
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
172-195 4.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.24e-04
                          10        20
                  ....*....|....*....|....
gi 124375892  172 NLTVHQRTHTGEKPYQCKECGKAF 195
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
424-449 5.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 124375892  424 SLTVHQRTHTGEKPYQCNECGKAFSR 449
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 438-460 6.78e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 6.78e-04
                          10        20
                  ....*....|....*....|...
gi 124375892  438 YQCNECGKAFSRSTNLTRHQRTH 460
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 154-237 6.97e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 6.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 154 GEKPYKCN--ECGKAFSQSMNLTVHqRTHtgekpyqcKECGKAFHKNSSLIQHERIHTGEKPYKCNECGKAFTQSMNLTV 231
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 124375892 232 HqRTHT 237
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
396-419 8.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.27e-04
                          10        20
                  ....*....|....*....|....
gi 124375892  396 YLIEHQRIHTGEKPYECDQCGKAF 419
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-309 1.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|....*
gi 124375892  285 LTLHQRNHTGEKPYKCNKCGKSFSQ 309
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-281 1.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.39e-03
                          10        20
                  ....*....|....*....|....*.
gi 124375892  256 HLIVHQRSHTGEKPYECSQCGKAFSK 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
116-139 2.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.29e-03
                          10        20
                  ....*....|....*....|....
gi 124375892  116 SLLKHQRIHTGEKPYKCNVCGKHF 139
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 184-232 2.35e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 2.35e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124375892 184 KPYqCKECGKAFHKNSSLIQHERIHTgekpYKCNECGKAFTQSMNLTVH 232
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-364 2.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.58e-03
                          10        20
                  ....*....|....*....|....*
gi 124375892  340 SLTQHRRIHTGEKPYECMVCGKHFT 364
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 158-180 3.92e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 3.92e-03
                          10        20
                  ....*....|....*....|...
gi 124375892  158 YKCNECGKAFSQSMNLTVHQRTH 180
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 214-236 4.04e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.04e-03
                          10        20
                  ....*....|....*....|...
gi 124375892  214 YKCNECGKAFTQSMNLTVHQRTH 236
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
368-393 4.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.43e-03
                          10        20
                  ....*....|....*....|....*.
gi 124375892  368 SLTVHQVIHTGEKPYECNECGKAFSQ 393
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 334-433 6.22e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 6.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 334 AFSKNSSL---TQHRRIHT-GEKPYECMV--CGKHFTGRSSLTVHQvIHtgekpyecNECGKAFSQSAYLIEHQRIHTGE 407
Cdd:COG5189  326 KLAHGGERnidTPSRMLKVkDGKPYKCPVegCNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKD 396

                         90       100
                 ....*....|....*....|....*.
gi 124375892 408 KPYECDQCGKAFIKNSSLTVHqRTHT 433
Cdd:COG5189  397 KPYRCEVCDKRYKNLNGLKYH-RKHS 421
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 132-263 6.63e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 39.08  E-value: 6.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 132 CNVCgKHFIERSSLTVHQ-------------------RIHTGEKPYKCNECGKAFSQSmNLTVHQRTHtgEKPYQCKeCG 192
Cdd:PLN03086 410 CRNC-KHYIPSRSIALHEaycsrhnvvcphdgcgivlRVEEAKNHVHCEKCGQAFQQG-EMEKHMKVF--HEPLQCP-CG 484

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 193 KAFHKNsSLIQHERIHTGEKPYKCNECG---KAFTQSM-------NLTVHQRThTGEKPYECNECGKAF---SQSMHLI- 258
Cdd:PLN03086 485 VVLEKE-QMVQHQASTCPLRLITCRFCGdmvQAGGSAMdvrdrlrGMSEHESI-CGSRTAPCDSCGRSVmlkEMDIHQIa 562


                 ....*
gi 124375892 259 VHQRS 263
Cdd:PLN03086 563 VHQKS 567
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 294-372 9.96e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.16  E-value: 9.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124375892 294 GEKPYKCN--KCGKSFSQSTYLIEHqRLHSgvkpfecnECGKAFSKNSSLTQHRRIHTGEKPYECMVCGKHFTGRSSLTV 371
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 124375892 372 H 372
Cdd:COG5189  417 H 417
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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