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Conserved domains on  [gi|124246642|gb|ABM92723|]
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sodium-calcium exchanger 1, partial [Ensatina eschscholtzii xanthoptica]

Protein Classification

CaCA family sodium/calcium exchanger( domain architecture ID 1000041)

CaCA family sodium/calcium exchanger mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane

Gene Ontology:  GO:0005432|GO:0006816|GO:0055085
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-229 3.47e-141

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 417.66  E-value: 3.47e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124246642    1 ITSQEKEITIKKPNGETTRTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGDLGPSTIVGSAAFNMFIIIAI 80
Cdd:TIGR00845 103 ITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDLGPSTIVGSAAFNMFIIIAI 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124246642   81 CVYVVPDGEIRKIKHLRVFFVTAAWSIFAYTWLYLILSVISPGVVEVWESMLTFFFFP*CVVFAWVADRRLLFYKYVYKR 160
Cdd:TIGR00845 183 CVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFPLCVVFAWVADRRLLFYKYVYKR 262

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124246642  161 YRAGKQRGMIIETEGDRPSSKADIEMDGKVVNSHTENFIDGSLVLEVDDKDqddeEARRDMARILKELK 229
Cdd:TIGR00845 263 YRAGKQRGMIIETEGDRPKSKTEIEMDGKMVNSHVDNFLDGALVLEVKEFD----EARREMIRILKELK 327
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-229 3.47e-141

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 417.66  E-value: 3.47e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124246642    1 ITSQEKEITIKKPNGETTRTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGDLGPSTIVGSAAFNMFIIIAI 80
Cdd:TIGR00845 103 ITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDLGPSTIVGSAAFNMFIIIAI 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124246642   81 CVYVVPDGEIRKIKHLRVFFVTAAWSIFAYTWLYLILSVISPGVVEVWESMLTFFFFP*CVVFAWVADRRLLFYKYVYKR 160
Cdd:TIGR00845 183 CVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFPLCVVFAWVADRRLLFYKYVYKR 262

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124246642  161 YRAGKQRGMIIETEGDRPSSKADIEMDGKVVNSHTENFIDGSLVLEVDDKDqddeEARRDMARILKELK 229
Cdd:TIGR00845 263 YRAGKQRGMIIETEGDRPKSKTEIEMDGKMVNSHVDNFLDGALVLEVKEFD----EARREMIRILKELK 327
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 149-229 5.20e-37

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 126.27  E-value: 5.20e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124246642  149 RRLLFYKYVYKRYRAGKQRGMIIETEGDR-PSSKADIEMDGKVVNSHTENFidGSLVLEVDDKDQDDEEARRDMARILKE 227
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELgPKEGIEMLMDGKLVGSHVMEG--GAEGPVDDPEAKELDEARREVIRILKE 78


                  ..
gi 124246642  228 LK 229
Cdd:pfam16494  79 LK 80
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
32-86 1.90e-06

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 47.44  E-value: 1.90e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 124246642  32 LTLMALGSSAPEILLSVIEVCGHNFqagDLGPSTIVGSAAFNMFIIIAICVYVVP 86
Cdd:COG0530   24 LTIVAFGTSLPELAVSVTAALDGSP---DIAVGNVVGSNIANILLILGLAALIRP 75
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 28-131 1.72e-03

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 38.98  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124246642  28 TVSNLTLMALGSSAPEILLSVIEVCGHNfqAGDLGPSTIVGSAAFNMFIIIAICVYVVPDGEIRKIKhlRVFFVTAAWSI 107
Cdd:PLN03151 178 TVAGVTLLPLGNGAPDVFASIAAFVGKD--AGEVGLNSVLGGAVFVTCVVVGIVSLCVADKEVQIDK--RCFIRDLCFFL 253

                         90       100
                 ....*....|....*....|....
gi 124246642 108 FAYTWLYLILSVispGVVEVWESM 131
Cdd:PLN03151 254 FTLVSLLVILMV---GKVTVGGAI 274
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-229 3.47e-141

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 417.66  E-value: 3.47e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124246642    1 ITSQEKEITIKKPNGETTRTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGDLGPSTIVGSAAFNMFIIIAI 80
Cdd:TIGR00845 103 ITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDLGPSTIVGSAAFNMFIIIAI 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124246642   81 CVYVVPDGEIRKIKHLRVFFVTAAWSIFAYTWLYLILSVISPGVVEVWESMLTFFFFP*CVVFAWVADRRLLFYKYVYKR 160
Cdd:TIGR00845 183 CVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFPLCVVFAWVADRRLLFYKYVYKR 262

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124246642  161 YRAGKQRGMIIETEGDRPSSKADIEMDGKVVNSHTENFIDGSLVLEVDDKDqddeEARRDMARILKELK 229
Cdd:TIGR00845 263 YRAGKQRGMIIETEGDRPKSKTEIEMDGKMVNSHVDNFLDGALVLEVKEFD----EARREMIRILKELK 327
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 149-229 5.20e-37

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 126.27  E-value: 5.20e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124246642  149 RRLLFYKYVYKRYRAGKQRGMIIETEGDR-PSSKADIEMDGKVVNSHTENFidGSLVLEVDDKDQDDEEARRDMARILKE 227
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELgPKEGIEMLMDGKLVGSHVMEG--GAEGPVDDPEAKELDEARREVIRILKE 78


                  ..
gi 124246642  228 LK 229
Cdd:pfam16494  79 LK 80
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 21-132 1.07e-13

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 66.09  E-value: 1.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124246642   21 TVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNfqaGDLGPSTIVGSAAFNMFIIIAICVYV--VPDGEIRKIKHLRV 98
Cdd:pfam01699  29 RVLGISGTVLGLTILALGTSLPELVSSIIAALRGE---PDLALGNVIGSNIFNILLVLGLSALIgpVKVDSLLLKLDLGV 105

                          90       100       110
                  ....*....|....*....|....*....|....
gi 124246642   99 FFVTAAWSIFAYTWLYLILsvisPGVVEVWESML 132
Cdd:pfam01699 106 LLLVALLLLLLLLLLLLPL----FGRLSRFEGLV 135
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
32-86 1.90e-06

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 47.44  E-value: 1.90e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 124246642  32 LTLMALGSSAPEILLSVIEVCGHNFqagDLGPSTIVGSAAFNMFIIIAICVYVVP 86
Cdd:COG0530   24 LTIVAFGTSLPELAVSVTAALDGSP---DIAVGNVVGSNIANILLILGLAALIRP 75
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 26-81 2.15e-06

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 48.07  E-value: 2.15e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 124246642    26 NETVSNLTLMALGSSAPEILLSVIEV-CGHNfqagDLGPSTIVGSAAFNMFIIIAIC 81
Cdd:TIGR00927  493 SEDVAGATFMAAGGSAPELFTSLIGVfISHS----NVGIGTIVGSAVFNILFVIGTC 545
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 32-120 3.32e-05

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 43.85  E-value: 3.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124246642   32 LTLMALGSSAPEILLSVIEVCGHNfqaGDLGPSTIVGSAAFNMFIIIAICVYVVPdgeirkikhlrvfFVTAAWSIFAYT 111
Cdd:TIGR00367  41 VTVVAIGTSLPELFTSLIASLMGQ---PDIGVGNVIGSNIFNILLILGLSAIFSP-------------IIVDKDWLRRDI 104


                  ....*....
gi 124246642  112 WLYLILSVI 120
Cdd:TIGR00367 105 LFYLLVSIL 113
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
25-132 1.04e-03

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 39.35  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124246642  25 WNETVSNLTLMALGSSAPEILLSVIEVcghnFQ-AGDLGPSTIVGSAAFNMFIIIAICVyVVPDGEIrkikhLRVFFVTA 103
Cdd:COG0530  184 VSELVIGLTIVAIGTSLPELATSIVAA----RKgEDDLAVGNIIGSNIFNILLVLGIGA-LITPIPV-----DPAVLSFD 253

                         90       100
                 ....*....|....*....|....*....
gi 124246642 104 AWSIFAYTWLYLILsVISPGVVEVWESML 132
Cdd:COG0530  254 LPVMLAATLLLLGL-LRTGGRIGRWEGLL 281
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 28-131 1.72e-03

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 38.98  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124246642  28 TVSNLTLMALGSSAPEILLSVIEVCGHNfqAGDLGPSTIVGSAAFNMFIIIAICVYVVPDGEIRKIKhlRVFFVTAAWSI 107
Cdd:PLN03151 178 TVAGVTLLPLGNGAPDVFASIAAFVGKD--AGEVGLNSVLGGAVFVTCVVVGIVSLCVADKEVQIDK--RCFIRDLCFFL 253

                         90       100
                 ....*....|....*....|....
gi 124246642 108 FAYTWLYLILSVispGVVEVWESM 131
Cdd:PLN03151 254 FTLVSLLVILMV---GKVTVGGAI 274
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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