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Conserved domains on  [gi|1240212099|gb|ASX98320|]
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cytochrome b, partial (mitochondrion) [Rana temporaria]

Protein Classification

cytochrome b( domain architecture ID 1000033)

cytochrome b is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain; contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis

CATH:  1.20.810.10
Gene Ontology:  GO:0009055|GO:0046872|GO:0022904|GO:0005743|GO:0020037
PubMed:  2509716|8329437
SCOP:  4002208

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
CYTB super family cl31791
cytochrome b; Provisional
 1-83 1.41e-48

cytochrome b; Provisional


The actual alignment was detected with superfamily member MTH00074:

Pssm-ID: 177145 [Multi-domain]  Cd Length: 380  Bit Score: 157.15  E-value: 1.41e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240212099   1 LTRFFTFHFILPFIIAAVSMIHLLFLHQTGSSNPTGLNSNLDKVSFHPYFSYKDLFGFVILLGALAALSTFSPNLLGDPD 80
Cdd:MTH00074  176 LTRFFAFHFLLPFLIAGASIIHLLFLHETGSNNPTGLNSNPDKVPFHPYFSYKDLLGFLIMLTALALLSLFSPNLLGDPD 255


                  ...
gi 1240212099  81 NFT 83
Cdd:MTH00074  256 NFT 258
 
Name Accession Description Interval E-value
CYTB MTH00074
cytochrome b; Provisional
 1-83 1.41e-48

cytochrome b; Provisional


Pssm-ID: 177145 [Multi-domain]  Cd Length: 380  Bit Score: 157.15  E-value: 1.41e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240212099   1 LTRFFTFHFILPFIIAAVSMIHLLFLHQTGSSNPTGLNSNLDKVSFHPYFSYKDLFGFVILLGALAALSTFSPNLLGDPD 80
Cdd:MTH00074  176 LTRFFAFHFLLPFLIAGASIIHLLFLHETGSNNPTGLNSNPDKVPFHPYFSYKDLLGFLIMLTALALLSLFSPNLLGDPD 255


                  ...
gi 1240212099  81 NFT 83
Cdd:MTH00074  256 NFT 258
Cytochrom_B_N_2 pfam13631
Cytochrome b(N-terminal)/b6/petB;
1-79 5.04e-19

Cytochrome b(N-terminal)/b6/petB;


Pssm-ID: 433364  Cd Length: 169  Bit Score: 75.74  E-value: 5.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240212099   1 LTRFFTFHF-ILPFIIAAVSMIHLLFLHQTGSSNPTGLNSNLDKVSFHPYFSYKDLFGFVILLGALAALSTFSPNLLGDP 79
Cdd:pfam13631  90 IPRFYALHIlLLPGLILALIVAHLLLVEKHGQFPPPGTEKNVVGVPFWPVFAVKMLLFFLITVALLIGLAQINPIWLGGP 169
QcrB/PetB COG1290
Cytochrome b subunit of the bc complex [Energy production and conversion];
1-82 9.23e-17

Cytochrome b subunit of the bc complex [Energy production and conversion];


Pssm-ID: 440901 [Multi-domain]  Cd Length: 393  Bit Score: 72.52  E-value: 9.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240212099   1 LTRFFTFH-FILPFIIAAVSMIHLLFLHQTGSSNPTG----LNSNLDKVSFHPYFSYKDLFGFVILLGALAALSTFSPNl 75
Cdd:COG1290   186 LNRFFALHvLLLPALLLALVVLHLWLLHRHGHNNPPGperkKTEKVDGVPFHPYYTVKDGFGFFVFLGVFALLAFFFPI- 264


                  ....*..
gi 1240212099  76 lGDPDNF 82
Cdd:COG1290   265 -NPPPNY 270
Cytochrome_b_N cd00284
Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit ...
 1-32 4.02e-08

Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, cytochrome b6 is analogous to eukaryote cytochrome b, containing two chains: helices A-D are encoded by the petB gene and helices E-H are encoded by the petD gene in these organisms. Cytochrome b/b6 contains two bound hemes and two ubiquinol/ubiquinone binding sites. The C-terminal portion of cytochrome b is described in a separate CD.


Pssm-ID: 238176  Cd Length: 200  Bit Score: 47.75  E-value: 4.02e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1240212099   1 LTRFFTFHFILPFIIAAVSMIHLLFLHQTGSS 32
Cdd:cd00284   169 LTRFFALHFLLPFIIAVIVILHLLFLHEQGSS 200
 
Name Accession Description Interval E-value
CYTB MTH00074
cytochrome b; Provisional
 1-83 1.41e-48

cytochrome b; Provisional


Pssm-ID: 177145 [Multi-domain]  Cd Length: 380  Bit Score: 157.15  E-value: 1.41e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240212099   1 LTRFFTFHFILPFIIAAVSMIHLLFLHQTGSSNPTGLNSNLDKVSFHPYFSYKDLFGFVILLGALAALSTFSPNLLGDPD 80
Cdd:MTH00074  176 LTRFFAFHFLLPFLIAGASIIHLLFLHETGSNNPTGLNSNPDKVPFHPYFSYKDLLGFLIMLTALALLSLFSPNLLGDPD 255


                  ...
gi 1240212099  81 NFT 83
Cdd:MTH00074  256 NFT 258
CYTB MTH00131
cytochrome b; Provisional
 1-83 8.30e-48

cytochrome b; Provisional


Pssm-ID: 177189 [Multi-domain]  Cd Length: 380  Bit Score: 155.20  E-value: 8.30e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240212099   1 LTRFFTFHFILPFIIAAVSMIHLLFLHQTGSSNPTGLNSNLDKVSFHPYFSYKDLFGFVILLGALAALSTFSPNLLGDPD 80
Cdd:MTH00131  175 LTRFFAFHFLFPFVIAAATILHLLFLHETGSNNPLGLNSDADKISFHPYFSYKDLLGFAILLLALTSLALFSPNLLGDPD 254


                  ...
gi 1240212099  81 NFT 83
Cdd:MTH00131  255 NFT 257
CYTB MTH00119
cytochrome b; Provisional
 1-83 7.20e-43

cytochrome b; Provisional


Pssm-ID: 214425 [Multi-domain]  Cd Length: 380  Bit Score: 142.35  E-value: 7.20e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240212099   1 LTRFFTFHFILPFIIAAVSMIHLLFLHQTGSSNPTGLNSNLDKVSFHPYFSYKDLFGFVILLGALAALSTFSPNLLGDPD 80
Cdd:MTH00119  176 LTRFFALHFLLPFLIAGLTLIHLLFLHETGSNNPLGLNSNTDKIPFHPYFSYKDLLGLTLMLTLLLTLALFSPNLLGDPE 255


                  ...
gi 1240212099  81 NFT 83
Cdd:MTH00119  256 NFT 258
CYTB MTH00191
cytochrome b; Provisional
 1-83 1.62e-42

cytochrome b; Provisional


Pssm-ID: 177239 [Multi-domain]  Cd Length: 365  Bit Score: 141.21  E-value: 1.62e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240212099   1 LTRFFTFHFILPFIIAAVSMIHLLFLHQTGSSNPTGLNSNLDKVSFHPYFSYKDLFGFVILLGALAALSTFSPNLLGDPD 80
Cdd:MTH00191  172 LTRFFTFHFLLPFLIAALSLIHLLFLHETGSNNPLGLNSDSDKIPFHPYFSYKDILGFFILLFLLLFLVLFSPNLLGDPE 251


                  ...
gi 1240212099  81 NFT 83
Cdd:MTH00191  252 NFI 254
CYTB MTH00156
cytochrome b; Provisional
 1-83 8.90e-42

cytochrome b; Provisional


Pssm-ID: 214440 [Multi-domain]  Cd Length: 356  Bit Score: 139.15  E-value: 8.90e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240212099   1 LTRFFTFHFILPFIIAAVSMIHLLFLHQTGSSNPTGLNSNLDKVSFHPYFSYKDLFGFVILLGALAALSTFSPNLLGDPD 80
Cdd:MTH00156  165 LTRFFTFHFLLPFIILAMVMIHLLFLHQTGSNNPLGLNSNIDKIPFHPYFTFKDLVGFIIMLMLLILLTLINPYLLGDPE 244


                  ...
gi 1240212099  81 NFT 83
Cdd:MTH00156  245 NFI 247
CYTB MTH00100
cytochrome b; Provisional
 1-83 3.91e-40

cytochrome b; Provisional


Pssm-ID: 177162 [Multi-domain]  Cd Length: 379  Bit Score: 135.15  E-value: 3.91e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240212099   1 LTRFFTFHFILPFIIAAVSMIHLLFLHQTGSSNPTGLNSNLDKVSFHPYFSYKDLFGFVILLGALAALSTFSPNLLGDPD 80
Cdd:MTH00100  175 LTRFFAFHFILPFIITALAMVHLLFLHETGSNNPSGIPSDSDKIPFHPYYTIKDILGLLLLILTLMLLVLFSPDLLGDPD 254


                  ...
gi 1240212099  81 NFT 83
Cdd:MTH00100  255 NYT 257
CYTB MTH00145
cytochrome b; Provisional
 1-83 2.78e-39

cytochrome b; Provisional


Pssm-ID: 177203 [Multi-domain]  Cd Length: 379  Bit Score: 133.11  E-value: 2.78e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240212099   1 LTRFFTFHFILPFIIAAVSMIHLLFLHQTGSSNPTGLNSNLDKVSFHPYFSYKDLFGFVILLGALAALSTFSPNLLGDPD 80
Cdd:MTH00145  176 LKRFFSLHFLLPFVILGLSVLHLLFLHETGSNNPLGLDSDGDKVPFHPYYTIKDLVGFVVLLFLLVFLVLFFPNLLGDPE 255


                  ...
gi 1240212099  81 NFT 83
Cdd:MTH00145  256 NFI 258
CYTB MTH00016
cytochrome b; Validated
 1-83 1.73e-36

cytochrome b; Validated


Pssm-ID: 177102 [Multi-domain]  Cd Length: 378  Bit Score: 125.56  E-value: 1.73e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240212099   1 LTRFFTFHFILPFIIAAVSMIHLLFLHQTGSSNPTGLNSNLDKVSFHPYFSYKDLFGFVILLGALAALSTFSPNLLGDPD 80
Cdd:MTH00016  176 LTRFFALHFLLPFVIAALSMIHLLFLHQTGSNNPLGVNSNSDKVPFHPYYTSKDIVGFIVMLFLLLSVVLLWPNILGDPE 255


                  ...
gi 1240212099  81 NFT 83
Cdd:MTH00016  256 NFI 258
CYTB MTH00034
cytochrome b; Validated
 1-82 6.03e-35

cytochrome b; Validated


Pssm-ID: 177109 [Multi-domain]  Cd Length: 379  Bit Score: 121.74  E-value: 6.03e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240212099   1 LTRFFTFHFILPFIIAAVSMIHLLFLHQTGSSNPTGLNSNLDKVSFHPYFSYKDLFGFVILLGALAALSTFSPNLLGDPD 80
Cdd:MTH00034  175 LTRFFAFHFLFPFIIAALSIIHLLFLHQTGSNNPTGLNSNYDKVPFHTYFTTKDLVGFLILFAALSSLALLFPTALNDPE 254


                  ..
gi 1240212099  81 NF 82
Cdd:MTH00034  255 NF 256
CYTB MTH00022
cytochrome b; Validated
 1-82 1.15e-27

cytochrome b; Validated


Pssm-ID: 164595 [Multi-domain]  Cd Length: 379  Bit Score: 102.47  E-value: 1.15e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240212099   1 LTRFFTFHFILPFIIAAVSMIHLLFLHQTGSSNPTGLNSNLDKVSFHPYFSYKDLFGFVILLGALAALSTFSPNLLGDPD 80
Cdd:MTH00022  174 LNRFFSLHFLFPFILAFLVIVHLIYLHVDGSNNPIGLNSSVDKVSFHVYYTSKDWYGIVVLFFLLSFIVYFAPNLLGDPE 253


                  ..
gi 1240212099  81 NF 82
Cdd:MTH00022  254 NF 255
CYTB MTH00224
cytochrome b; Provisional
 1-82 5.07e-27

cytochrome b; Provisional


Pssm-ID: 164767 [Multi-domain]  Cd Length: 379  Bit Score: 100.77  E-value: 5.07e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240212099   1 LTRFFTFHFILPFIIAAVSMIHLLFLHQTGSSNPTGLNSNLDKVSFHPYFSYKDLFGFVILLGALAALSTFSPNLLGDPD 80
Cdd:MTH00224  176 LNRFFSFHFLLPFAIMGATILHIMFLHQTGSNNPIGINADSARIPFHPYYSIKDALGYLIAILLLSLMVLFEPNLFTDPE 255


                  ..
gi 1240212099  81 NF 82
Cdd:MTH00224  256 NF 257
CYTB MTH00053
cytochrome b; Provisional
 1-82 8.35e-24

cytochrome b; Provisional


Pssm-ID: 164624 [Multi-domain]  Cd Length: 381  Bit Score: 92.08  E-value: 8.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240212099   1 LTRFFTFHFILPFIIAAVSMIHLLFLHQTGSSNPTGLNSNLDKVSFHPYFSYKDLFGFVILLGALAALSTFSPNLLGDPD 80
Cdd:MTH00053  176 LNRFYSLHYLLPFILAGLALVHLIALHEDGSNNPIGVRSDIDKIPFHYYYVLKDLYGAVILLIILSIIVFLFPYSLGDAE 255


                  ..
gi 1240212099  81 NF 82
Cdd:MTH00053  256 NF 257
Cytochrom_B_N_2 pfam13631
Cytochrome b(N-terminal)/b6/petB;
1-79 5.04e-19

Cytochrome b(N-terminal)/b6/petB;


Pssm-ID: 433364  Cd Length: 169  Bit Score: 75.74  E-value: 5.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240212099   1 LTRFFTFHF-ILPFIIAAVSMIHLLFLHQTGSSNPTGLNSNLDKVSFHPYFSYKDLFGFVILLGALAALSTFSPNLLGDP 79
Cdd:pfam13631  90 IPRFYALHIlLLPGLILALIVAHLLLVEKHGQFPPPGTEKNVVGVPFWPVFAVKMLLFFLITVALLIGLAQINPIWLGGP 169
QcrB/PetB COG1290
Cytochrome b subunit of the bc complex [Energy production and conversion];
1-82 9.23e-17

Cytochrome b subunit of the bc complex [Energy production and conversion];


Pssm-ID: 440901 [Multi-domain]  Cd Length: 393  Bit Score: 72.52  E-value: 9.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240212099   1 LTRFFTFH-FILPFIIAAVSMIHLLFLHQTGSSNPTG----LNSNLDKVSFHPYFSYKDLFGFVILLGALAALSTFSPNl 75
Cdd:COG1290   186 LNRFFALHvLLLPALLLALVVLHLWLLHRHGHNNPPGperkKTEKVDGVPFHPYYTVKDGFGFFVFLGVFALLAFFFPI- 264


                  ....*..
gi 1240212099  76 lGDPDNF 82
Cdd:COG1290   265 -NPPPNY 270
CYTB MTH00086
cytochrome b; Provisional
 4-82 2.56e-16

cytochrome b; Provisional


Pssm-ID: 177151 [Multi-domain]  Cd Length: 355  Bit Score: 71.12  E-value: 2.56e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1240212099   4 FFTFHFILPFIIAAVSMIHLLFLHQTGSSNPTGLNSNLDKVSFHPYFSYKDLFGFVILLgALAALSTFSPNLLGDPDNF 82
Cdd:MTH00086  167 FFVLHFLLPWGLLVLVLFHLIFLHSTGSTSSLYCHGDYDKICFGPEYWNKDAYNIIFWL-VFIIFSLFYPFNLGDPEMF 244
CYTB MTH00033
cytochrome b; Provisional
 1-82 6.33e-15

cytochrome b; Provisional


Pssm-ID: 133672 [Multi-domain]  Cd Length: 383  Bit Score: 67.66  E-value: 6.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1240212099   1 LTRFFTFHFILPFIIAAVSMIHLLFLHQTGSSNPTGLNSNLDKVSFHPYFSYKDLFGFVILLGALA--ALSTFSPNLLGD 78
Cdd:MTH00033  172 LNRFFSLHYLLPFVLVGLVLAHLLTLHEKGSNEPLGLVGLSDRTAFHVYFTIKDILGFLILFGVFViiGIEPRIETLLQD 251


                  ....
gi 1240212099  79 PDNF 82
Cdd:MTH00033  252 PENF 255
CYTB MTH00046
cytochrome b; Validated
 1-78 2.41e-14

cytochrome b; Validated


Pssm-ID: 177121 [Multi-domain]  Cd Length: 355  Bit Score: 65.77  E-value: 2.41e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1240212099   1 LTRFFTFHFILPFIIAAVSMIHLLFLHQTGSSNPTGLNSNL-DKVSFHPYFSYKDLFGFVILLGALAALSTFSPNLLGD 78
Cdd:MTH00046  166 LVRVFSVHICLGFVILGLMVVHLFYLHKSGSSNPLFSSNGYsDVVYFHSYFTVKDLFLFMVVCSLLVFWLFVSPDLVLD 244
Cytochrome_b_N cd00284
Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit ...
 1-32 4.02e-08

Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, cytochrome b6 is analogous to eukaryote cytochrome b, containing two chains: helices A-D are encoded by the petB gene and helices E-H are encoded by the petD gene in these organisms. Cytochrome b/b6 contains two bound hemes and two ubiquinol/ubiquinone binding sites. The C-terminal portion of cytochrome b is described in a separate CD.


Pssm-ID: 238176  Cd Length: 200  Bit Score: 47.75  E-value: 4.02e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1240212099   1 LTRFFTFHFILPFIIAAVSMIHLLFLHQTGSS 32
Cdd:cd00284   169 LTRFFALHFLLPFIIAVIVILHLLFLHEQGSS 200
Cytochrome_B pfam00033
Cytochrome b/b6/petB;
1-30 9.85e-07

Cytochrome b/b6/petB;


Pssm-ID: 306530  Cd Length: 189  Bit Score: 43.91  E-value: 9.85e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1240212099   1 LTRFFTFHFILPFIIAAVSMIHLLFLHQTG 30
Cdd:pfam00033 160 LTRFFSLHFLLPFILAILMLLHLLFLHETG 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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