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Conserved domains on  [gi|124015243|gb|ABM88751|]
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erythrocyte membrane protein 1 [Plasmodium falciparum]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ATS pfam15445
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and ...
2548-2975 0e+00

acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and relatively conserved acidic terminal segment of the Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1). this domain appears to be present in all variants of the highly polymorphic PfEMP1 proteins.


:

Pssm-ID: 373851 [Multi-domain]  Cd Length: 446  Bit Score: 751.25  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2548 TIPIGISLALGSIAFLFIKKKTKSSVGNLFQILQIPKSDYNIPTLKSKNRYIPYRSGTYKGKTYIYMEGDSSGDEKYAFM 2627
Cdd:pfam15445    1 TIPWSVGIAFAAFTYFFLKKKTKSSVGNLFQILQIPKGDYDIPTLKSKNRYIPYASDRYKGKTYIYMEGDSSGDEKYAFM 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2628 SDTTDVTSSESEYEELDISDIYVPGSPKYKTLIEVVLEPSGNNTtasdkNTPSDTQNDIQNDGIPSS-KITDNEWNTLKD 2706
Cdd:pfam15445   81 SDTTDITSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSKNNT-----NTPSDTQNDIPSDDIPSTnKITDEEWNTLKH 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2707 EFISQYLQSEPLDVPNDYSSRDIPFNTQPSTLYFDNNQEKPFITSIHDRNLYSGEEYN--YNVNMVNNDDIPINRDNNVY 2784
Cdd:pfam15445  156 DFISNMLQNTQNDEPNILHSGNVPNNTHPNTLSRDNMEEKPFIMSIHDRNLYTGEEYSynINMSTNSMDDIPKYVSNNVY 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2785 SGIDLINDALNGD--YDIYDEILKRKENELFGTNHTKHTTTNRVATQICDGPITNQLNLFHRWLDRHRNMCEQWNNKEDI 2862
Cdd:pfam15445  236 SGIDLINDTLSGNqhIDIYDEVLKRKENELFGTNHTKHTSTNSVAKNTNSDPILNQLNLFHKWLDRHRDMCEKWKNKEER 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2863 LNKLNEEWNKDNDRA-------NVPNDNKTLNTDVSIQIHMDNPKPINEFTN---------MDTILDDLEKYNEPYYDV- 2925
Cdd:pfam15445  316 LDKLKEEWNKENNHSgdihpsdDIPSDNKVLNTDVSIQIDMDNPKPKNEFTNmdtnpdnstMDTILDDLEKYNEPYYDIy 395
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 124015243  2926 QDDIYYDVHDHDASTVDTNAMDVPSKVQIEMDVNT-KLVKEKYPISDVWDI 2975
Cdd:pfam15445  396 EDDIYYDVNDHDASTVDSNNMDVPSKVQIEMDVNNtKLVEEKYPISDVWNI 446
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
116-311 1.28e-88

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


:

Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 286.48  E-value: 1.28e-88
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   116 ACAPYRRLHLCDYNLEKMGRT-STTKHDLLAEVCMAAKYEGGSIKTHYTPHQHKYGDSDSQICTVLARSFADIGDIIRGK 194
Cdd:pfam05424    1 ACAPPRRLHLCVKNLEKINSGnTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTKYGDIPSEFCRQMAYSFADIGDIIRGK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   195 DLYLGDKKKKqnetereKLEQKLKEIFKKIHSEVTTNgelqkryGQDGQNFYQLREDWWYANRETVWKAMTCEAPESASY 274
Cdd:pfam05424   81 DLYLGNNKKK-------KLEENLKKIFKKIYEKLTSK-------GKDDGNYYQLREDWWEANREDIWKAMTCALTYGAKY 146
                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 124015243   275 FRKTCDGGENPTATqgnckCINGDVPTYFDYVPQYLR 311
Cdd:pfam05424  147 FRKTCGDGISPSTA-----GCNDDVPTYFDYVPQFLR 178
PTZ00176 super family cl31413
erythrocyte membrane protein 1 (PfEMP1); Provisional
16-413 2.28e-67

erythrocyte membrane protein 1 (PfEMP1); Provisional


The actual alignment was detected with superfamily member PTZ00176:

Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 252.65  E-value: 2.28e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   16 KDAKNLLDSIGKIVHDQVKNgeAQTYKEALKGDLQKA---NGIGE-----RASSNKTCDLVQEYYGRADN---SNRYPCA 84
Cdd:PTZ00176   13 LSARNVLENIGNEIKDKREN--ESKYTDKLKGSLWEArfsDGLSSsfgdvRSGYYDSCSLDHKFHTNINNgypPARNPCD 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   85 NRQTVRFSDEYGGQCTYNRIKDSENNDNSiGACAPYRRLHLCDYNLEKMGRTST-TKHDLLAEVCMAAKYEGGSIKTHYt 163
Cdd:PTZ00176   91 GRNQNRFDENGESYCNSDKIRGNENNSNA-GACAPFRRQNMCDKNLEYLINKNTeNTHDLLGNVLVTAKYEGESIVNNH- 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  164 PHQHKygdsdSQICTVLARSFADIGDIIRGKDLYlgdKKKKQNEterekLEQKLKEIFKKIHSEVTTNGeLQKRYGQDGQ 243
Cdd:PTZ00176  169 PDKDK-----SSVCTALARSFADIGDIVRGKDMF---KRNKHDN-----VENGLREVFKKIYEGLKNNG-AREHYKEVKN 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  244 -NFYQLREDWWYANRETVWKAMTCEAPESAsYFRKT-CDGGENPTATQGNCKCINGDVPTYFDYVPQYLRWFEEWAEDFC 321
Cdd:PTZ00176  235 gNYIKLREDWWTANRDQVWKAMTCVAPENA-YFRKTeADGIGISSLILPYSKCGRDTDPPVVDYIPQRLRWMSEWSEYFC 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  322 RKREYKLENAKNKCRgnyengepkycsrngyDCKKTVRGKNilvsDTE---CTKCSVVCTPFVKWIDNQKEEFLKQKEKY 398
Cdd:PTZ00176  314 NVLNKEIDEMNNQCK----------------DCEMSRRCNN----DTEgekCKKCKEQCQIFKELVSKWKNQFDKQSMKY 373
                         410
                  ....*....|....*
gi 124015243  399 hKEIQKKedKTTTIT 413
Cdd:PTZ00176  374 -MELYNK--ASTNIT 385
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
852-1030 1.37e-51

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


:

Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 180.55  E-value: 1.37e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   852 AYMPPRRQHMCTSNLENLDVDSVIKNdkasHSLLGDVLLSANHEAKKIKELYEKnkdqsgQNDKNGLTDDkTVCRAMKNS 931
Cdd:pfam05424    1 ACAPPRRLHLCVKNLEKINSGNTTTT----HDLLKAVILAAKYEGFSLWHKYKK------KNTKYGDIPS-EFCRQMAYS 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   932 FADIGDIIRGRDLWD-NKDQVTLQDHLKTIFGKIKGELKGEDKynrddkKSPPYKQLRADWWEANRDQIWEAMIC----- 1005
Cdd:pfam05424   70 FADIGDIIRGKDLYLgNNKKKKLEENLKKIFKKIYEKLTSKGK------DDGNYYQLREDWWEANREDIWKAMTCaltyg 143
                          170       180       190
                   ....*....|....*....|....*....|....*
gi 124015243  1006 ----------ETKSHPTIKCDKTTPYDDYIPQRLR 1030
Cdd:pfam05424  144 akyfrktcgdGISPSTAGCNDDVPTYFDYVPQFLR 178
PTZ00176 super family cl31413
erythrocyte membrane protein 1 (PfEMP1); Provisional
816-1196 5.31e-50

erythrocyte membrane protein 1 (PfEMP1); Provisional


The actual alignment was detected with superfamily member PTZ00176:

Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 196.79  E-value: 5.31e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  816 NGNNG-----EPCEGKDgsNKRFEIGTKWETG-----GTVQMTETEAYMPPRRQHMCTSNLENLdvdsVIKNDKASHSLL 885
Cdd:PTZ00176   77 NINNGypparNPCDGRN--QNRFDENGESYCNsdkirGNENNSNAGACAPFRRQNMCDKNLEYL----INKNTENTHDLL 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  886 GDVLLSANHEAKKIKELYeKNKDQSgqndkngltddkTVCRAMKNSFADIGDIIRGRDLWDNKDQVTLQDHLKTIFGKIK 965
Cdd:PTZ00176  151 GNVLVTAKYEGESIVNNH-PDKDKS------------SVCTALARSFADIGDIVRGKDMFKRNKHDNVENGLREVFKKIY 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  966 GELKGEDKYNR-DDKKSPPYKQLRADWWEANRDQIWEAMICETKSH------------------PTIKCDKTT--PYDDY 1024
Cdd:PTZ00176  218 EGLKNNGAREHyKEVKNGNYIKLREDWWTANRDQVWKAMTCVAPENayfrkteadgigisslilPYSKCGRDTdpPVVDY 297
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 1025 IPQRLRWMTEWAEWYCKAQTEAYGELLRDCGSCTGKVQCKEGTK--ECKDCKSSCEKYTEFVNKWKPQWNTMEIKYVPLY 1102
Cdd:PTZ00176  298 IPQRLRWMSEWSEYFCNVLNKEIDEMNNQCKDCEMSRRCNNDTEgeKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELY 377
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 1103 LQAKN--AYYGISFPGADY---------------QLMVDFLSKLHTSSVAAIGKNGETTNspyatpagyihqearvgKCL 1165
Cdd:PTZ00176  378 NKASTniTKQNSSAPERGYrrnhrrrgydddtnvQLFLKKVIENNECKVESLGKYLDKTS-----------------HCG 440
                         410       420       430
                  ....*....|....*....|....*....|..
gi 124015243 1166 EQNVFCDNN-GNNEKYAFKKTPPLYKYACECK 1196
Cdd:PTZ00176  441 NYNFNYDNTpGSNRSNAFEITPEKFKKACKCK 472
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
2169-2350 6.14e-43

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


:

Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 155.89  E-value: 6.14e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2169 ACIPPRRQKLCVHYLKQ----SMTNTNELKYAFIKCAAAETFLLWQYYKSKNGNannldntliGGNIPEEFKRQMFYTFG 2244
Cdd:pfam05424    1 ACAPPRRLHLCVKNLEKinsgNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTK---------YGDIPSEFCRQMAYSFA 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2245 DYRDLCLDTDLSSKTDIHSAVsiaKDNIYKVFKKNYQTSIDH----------RKSWWETNGPVIWEGMLCALEK-ASGDK 2313
Cdd:pfam05424   72 DIGDIIRGKDLYLGNNKKKKL---EENLKKIFKKIYEKLTSKgkddgnyyqlREDWWEANREDIWKAMTCALTYgAKYFR 148
                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 124015243  2314 DKLIGDNSIYTyanvkFSGGDNPPTLekFAQRPQFLR 2350
Cdd:pfam05424  149 KTCGDGISPST-----AGCNDDVPTY--FDYVPQFLR 178
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
1307-1533 3.05e-34

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


:

Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 130.86  E-value: 3.05e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  1307 ICIPPRRRKLYVTPLTKWENNSgsdtvvsgetlktsgTSSQSDktppastpatsstsstssqnatqLLTAFVESAAVETF 1386
Cdd:pfam05424    1 ACAPPRRLHLCVKNLEKINSGN---------------TTTTHD-----------------------LLKAVILAAKYEGF 42
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  1387 FLWDRYkkikekeieekrkrengglyiiikkkdilsdqdhPQNKLNRGEIPEEFKRQMFYTLADYKDILFSGskddntks 1466
Cdd:pfam05424   43 SLWHKY----------------------------------KKKNTKYGDIPSEFCRQMAYSFADIGDIIRGK-------- 80
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  1467 stynDILRGDKEiqerERKVKDAINNYFSNNGNKQP--PSSPPNSEKL-KSWWNNNAKHIWNAMVCALTY 1533
Cdd:pfam05424   81 ----DLYLGNNK----KKKLEENLKKIFKKIYEKLTskGKDDGNYYQLrEDWWEANREDIWKAMTCALTY 142
PFEMP super family cl03834
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ...
590-734 4.13e-27

PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.


The actual alignment was detected with superfamily member pfam03011:

Pssm-ID: 281064  Cd Length: 154  Bit Score: 109.51  E-value: 4.13e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   590 LFLNWIDEMLKDSILWRKELDRCIKNEKESNCIRECKSKCDCFERWVEQKEQEWKQLEKHY-EEEDFSEDFGIEWTPYGT 668
Cdd:pfam03011    1 LFKRWVEYFLEDSIKWRKKLKSCINNGKGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFlKQYKLKGLTGKTLDEYLD 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124015243   669 LELYL-KNIYLEMIQKDYPQEKLVQEM-QTINEENSNDIFN---CTKENNSITKFLQHEAQEAKKCKENNP 734
Cdd:pfam03011   81 LKSFLeTFLFYIDIKEAYGDVKELKKLeEILDEEGCSAGAEsakNNKNEDAIDKLLDKEEKKANNCKEKHK 151
PFEMP super family cl03834
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ...
1890-2037 4.54e-20

PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.


The actual alignment was detected with superfamily member pfam03011:

Pssm-ID: 281064  Cd Length: 154  Bit Score: 89.48  E-value: 4.54e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  1890 FLEYWLEDFIESYYILKKKklIEQCTKNG-GETCNENSKNGCACVKEWVEQKTTEWGDIKKHF----KIQNRENAFDIKY 1964
Cdd:pfam03011    1 LFKRWVEYFLEDSIKWRKK--LKSCINNGkGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFlkqyKLKGLTGKTLDEY 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124015243  1965 K-VETFLGDLIPRMDLTNGKEKIQELNKFLRSY-ECNCAENSPNGKESTPKDIVECLLTKLEDKANKCKTQTSGS 2037
Cdd:pfam03011   79 LdLKSFLETFLFYIDIKEAYGDVKELKKLEEILdEEGCSAGAESAKNNKNEDAIDKLLDKEEKKANNCKEKHKEN 153
CIDR1_gamma super family cl39882
Cysteine-Rich Interdomain Region 1 gamma; Rosetting is the capacity of infected RBCs to bind ...
1814-1874 2.83e-09

Cysteine-Rich Interdomain Region 1 gamma; Rosetting is the capacity of infected RBCs to bind uninfected RBCs, which is consistently associated with severe malaria in African children. The rosette-forming PfEMP1 adhesins, namely IT4/R29, Palo Alto 89F5 VarO, 3D7/PF13_0003 and IT4/var60, belong to a specific sub-group called groupA/UpsA var genes and all four present a specific Duffy Binding-Like and and Cysteine-Rich Interdomain Region (DBL1alpha1-CIDR1gamma) double domain Head region found at the extracellular region of PfEMP1. This entry represents the CIDR1gamma domain which increases the binding affinity to VarO (Palo Alto VarO parasites).


The actual alignment was detected with superfamily member pfam18562:

Pssm-ID: 408346  Cd Length: 52  Bit Score: 54.97  E-value: 2.83e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124015243  1814 TANITVEMVDRRGPFIEKYLRNsktsqnslFKDSYLFKSVRNQNWTCKfNGENMDICKLTN 1874
Cdd:pfam18562    1 TTTIDMLVSDNRGIKFENDLKE--------CKEAGIFKGIRKDQWKCG-KVCGYDVCKLKN 52
PTZ00176 super family cl31413
erythrocyte membrane protein 1 (PfEMP1); Provisional
1471-1769 1.32e-03

erythrocyte membrane protein 1 (PfEMP1); Provisional


The actual alignment was detected with superfamily member PTZ00176:

Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 44.64  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 1471 DILRG--------DKEIQERERKVKDAINNYFSNNGNKQ--PPSSPPNSEKLKS-WWNNNAKHIWNAMVC-----ALTYK 1534
Cdd:PTZ00176  189 DIVRGkdmfkrnkHDNVENGLREVFKKIYEGLKNNGAREhyKEVKNGNYIKLREdWWTANRDQVWKAMTCvapenAYFRK 268
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 1535 ENGSGGDgkttitqdeslkeqllengkqpkqngthdytYENVVLkdensdtrPKTTGGEKTTlntPKLRDFveIPTFFRY 1614
Cdd:PTZ00176  269 TEADGIG-------------------------------ISSLIL--------PYSKCGRDTD---PPVVDY--IPQRLRW 304
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 1615 LHEWGEEFCRKRKDKFKKLDKECRgvnnsgdpkycsgdghDCEKnSLKHHKMFEDSLCSGCYEQCRKYR----KW---ID 1687
Cdd:PTZ00176  305 MSEWSEYFCNVLNKEIDEMNNQCK----------------DCEM-SRRCNNDTEGEKCKKCKEQCQIFKelvsKWknqFD 367
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 1688 IKFVEYHKQEKKYEEEKQKLNGNSNNEVY---------------QKFYEQIKEK-----KTAAGFLQSLKHCKN---NEG 1744
Cdd:PTZ00176  368 KQSMKYMELYNKASTNITKQNSSAPERGYrrnhrrrgydddtnvQLFLKKVIENneckvESLGKYLDKTSHCGNynfNYD 447
                         330       340
                  ....*....|....*....|....*
gi 124015243 1745 DGSDPNNKISFENPLETFNPSTYCK 1769
Cdd:PTZ00176  448 NTPGSNRSNAFEITPEKFKKACKCK 472
 
Name Accession Description Interval E-value
ATS pfam15445
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and ...
2548-2975 0e+00

acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and relatively conserved acidic terminal segment of the Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1). this domain appears to be present in all variants of the highly polymorphic PfEMP1 proteins.


Pssm-ID: 373851 [Multi-domain]  Cd Length: 446  Bit Score: 751.25  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2548 TIPIGISLALGSIAFLFIKKKTKSSVGNLFQILQIPKSDYNIPTLKSKNRYIPYRSGTYKGKTYIYMEGDSSGDEKYAFM 2627
Cdd:pfam15445    1 TIPWSVGIAFAAFTYFFLKKKTKSSVGNLFQILQIPKGDYDIPTLKSKNRYIPYASDRYKGKTYIYMEGDSSGDEKYAFM 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2628 SDTTDVTSSESEYEELDISDIYVPGSPKYKTLIEVVLEPSGNNTtasdkNTPSDTQNDIQNDGIPSS-KITDNEWNTLKD 2706
Cdd:pfam15445   81 SDTTDITSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSKNNT-----NTPSDTQNDIPSDDIPSTnKITDEEWNTLKH 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2707 EFISQYLQSEPLDVPNDYSSRDIPFNTQPSTLYFDNNQEKPFITSIHDRNLYSGEEYN--YNVNMVNNDDIPINRDNNVY 2784
Cdd:pfam15445  156 DFISNMLQNTQNDEPNILHSGNVPNNTHPNTLSRDNMEEKPFIMSIHDRNLYTGEEYSynINMSTNSMDDIPKYVSNNVY 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2785 SGIDLINDALNGD--YDIYDEILKRKENELFGTNHTKHTTTNRVATQICDGPITNQLNLFHRWLDRHRNMCEQWNNKEDI 2862
Cdd:pfam15445  236 SGIDLINDTLSGNqhIDIYDEVLKRKENELFGTNHTKHTSTNSVAKNTNSDPILNQLNLFHKWLDRHRDMCEKWKNKEER 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2863 LNKLNEEWNKDNDRA-------NVPNDNKTLNTDVSIQIHMDNPKPINEFTN---------MDTILDDLEKYNEPYYDV- 2925
Cdd:pfam15445  316 LDKLKEEWNKENNHSgdihpsdDIPSDNKVLNTDVSIQIDMDNPKPKNEFTNmdtnpdnstMDTILDDLEKYNEPYYDIy 395
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 124015243  2926 QDDIYYDVHDHDASTVDTNAMDVPSKVQIEMDVNT-KLVKEKYPISDVWDI 2975
Cdd:pfam15445  396 EDDIYYDVNDHDASTVDSNNMDVPSKVQIEMDVNNtKLVEEKYPISDVWNI 446
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
2149-2975 8.04e-166

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 551.56  E-value: 8.04e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2149 KETYSEWTCDENKIKIG-QEGACIPPRRQKLCVHYLKQS---MTNTNELKYAFIKCAAAETFLLWQYYKskngnannldn 2224
Cdd:PTZ00176  504 KNDLSEWNNSGVKNKENdNNGVLVPPRRRNLCINLFSKKdykMKDENDFKEDLLNAAFSQGKLLGKKYS----------- 572
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2225 tliggNIPEEFKRQMFYTFGDYRDLCLDTDLSSKTdihSAVSIAKDNIYKVFKKNyQTSIDhRKSWWETNGPVIWEGMLC 2304
Cdd:PTZ00176  573 -----NYSNEAYEAMKFSYADYSDIVKGTDMMNDL---KKLNKELNTLLKETEKG-DISVD-RKTWWDDNKNVVWNAMLC 642
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2305 ALeKASGDKDKLigdNSiyTYANVkfSGGDNPPtlekfaqrpQFLRWMTEWGENFCKEQKREYKVLLAKCKDCdVDG--- 2381
Cdd:PTZ00176  643 GY-KTENENQQL---NS--SWCNV--PDDDNID---------QFLRWLTEWAQQYCKEKLIKAHIINTKCKDI-VEGrkh 704
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2382 DGKCNGKCVACKKQCKEYQYWLEKWINNYKKQKGRYTQVKEIPlyKDDKDLQASDDARVYLDTQLKNMTCT--------N 2453
Cdd:PTZ00176  705 KSMVDITDVECKRLFIDYEEWFRYRYNQWKGLSEKYIKIKKSK--NSGVNIPSEECAASYVTKHCNGCICNlrdmedihK 782
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2454 GSTNENCEYKCMNKASSTNTD--------MPESLDEKPKKVKDKCNCIRDECS-GLSvtgsGFSHVSAFGGGVPEPKCKG 2524
Cdd:PTZ00176  783 NINNQNELMKEMINIIKFDTDqyrtqlqnISNSMEINPKSVKTAVDTTKDIVSyGLA----GTMGVAAIGLQAGDFLGKK 858
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2525 FEEHLPKKMEP--PQYDPTNDILKT------TIPIGISLALGSIAFLF-IKKKTKSSVgNLFQILQIPKSDYNIPTLKSK 2595
Cdd:PTZ00176  859 IQDLYNEFMKPveKKLDTSSKNLNIyedpniMVPAGIGVALTLGLLLFkMRRKAKRQV-DMIRILQMSQNEYGIPTTKSP 937
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2596 NRYIPYRSGTYKGKTYIYMEGDSSgDEKYAFMSDTTDVTSSESEYEELDISDIYVPGSPKYKTLIEVVLEPSgnnttasd 2675
Cdd:PTZ00176  938 NKYVPYGSQRYKGKTYLYVEGDTD-EEKYMFMSDTTDITSSESEYEEMDINDIYVPGSPKYKTLIEVVLEPS-------- 1008
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2676 kntPSDTQNDIQNDGIPSSKITDNEWNTLKDEFISQYLQSEPLDvpNDYSSRDIPFNTQPSTLYFDNNQEKPFITSIHDR 2755
Cdd:PTZ00176 1009 ---KRDTQNDIPSDNTPSYKLTDEEWNQLKDDFISQYLPNTEPN--NNYRSGNSPTNTNNTTTSHDNMGEKPFIMSIHDR 1083
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2756 NLYSGEEYNYN-VNMVNNDDIPINRDNNVYSGIDLINDALNGD--YDIYDEILKRKENELFGTNHTKHTTTNRVA-TQIC 2831
Cdd:PTZ00176 1084 NLYTGEEISYNiNMSTNTMDDPKYVSNNVYSGIDLINDTLSGNqhIDIYDEVLKRKENELFGTNHVKQTSIHSVAkNTYS 1163
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2832 DGPITNQLNLFHRWLDRHRNMCEQWNNKEDILNKLNEEWNKDNDRANVPNDNKTLNTDVSIQIHMDNPKPINEFTNMDTI 2911
Cdd:PTZ00176 1164 DDAITNKINLFHKWLDRHRDMCEKWENHHERLAKLKEKWENDNDGGNVPSDNHVLNTDVSIEIDMDNPKPINQFSNMDIN 1243
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124015243 2912 LDdlekyNEPYYDVQDDIYYDVHDHDAS---------TVDTNA--MDVPSKVQIEMDV--NTK--LVKEKYPISDVWDI 2975
Cdd:PTZ00176 1244 VD-----TPTMDNMEDDIYYDVNDNDDDndqpsvydiPMDHNKvdVDVPKKVHIEMKIlnNTSngSLEQQFPISDVWNI 1317
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
116-311 1.28e-88

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 286.48  E-value: 1.28e-88
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   116 ACAPYRRLHLCDYNLEKMGRT-STTKHDLLAEVCMAAKYEGGSIKTHYTPHQHKYGDSDSQICTVLARSFADIGDIIRGK 194
Cdd:pfam05424    1 ACAPPRRLHLCVKNLEKINSGnTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTKYGDIPSEFCRQMAYSFADIGDIIRGK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   195 DLYLGDKKKKqnetereKLEQKLKEIFKKIHSEVTTNgelqkryGQDGQNFYQLREDWWYANRETVWKAMTCEAPESASY 274
Cdd:pfam05424   81 DLYLGNNKKK-------KLEENLKKIFKKIYEKLTSK-------GKDDGNYYQLREDWWEANREDIWKAMTCALTYGAKY 146
                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 124015243   275 FRKTCDGGENPTATqgnckCINGDVPTYFDYVPQYLR 311
Cdd:pfam05424  147 FRKTCGDGISPSTA-----GCNDDVPTYFDYVPQFLR 178
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
16-413 2.28e-67

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 252.65  E-value: 2.28e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   16 KDAKNLLDSIGKIVHDQVKNgeAQTYKEALKGDLQKA---NGIGE-----RASSNKTCDLVQEYYGRADN---SNRYPCA 84
Cdd:PTZ00176   13 LSARNVLENIGNEIKDKREN--ESKYTDKLKGSLWEArfsDGLSSsfgdvRSGYYDSCSLDHKFHTNINNgypPARNPCD 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   85 NRQTVRFSDEYGGQCTYNRIKDSENNDNSiGACAPYRRLHLCDYNLEKMGRTST-TKHDLLAEVCMAAKYEGGSIKTHYt 163
Cdd:PTZ00176   91 GRNQNRFDENGESYCNSDKIRGNENNSNA-GACAPFRRQNMCDKNLEYLINKNTeNTHDLLGNVLVTAKYEGESIVNNH- 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  164 PHQHKygdsdSQICTVLARSFADIGDIIRGKDLYlgdKKKKQNEterekLEQKLKEIFKKIHSEVTTNGeLQKRYGQDGQ 243
Cdd:PTZ00176  169 PDKDK-----SSVCTALARSFADIGDIVRGKDMF---KRNKHDN-----VENGLREVFKKIYEGLKNNG-AREHYKEVKN 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  244 -NFYQLREDWWYANRETVWKAMTCEAPESAsYFRKT-CDGGENPTATQGNCKCINGDVPTYFDYVPQYLRWFEEWAEDFC 321
Cdd:PTZ00176  235 gNYIKLREDWWTANRDQVWKAMTCVAPENA-YFRKTeADGIGISSLILPYSKCGRDTDPPVVDYIPQRLRWMSEWSEYFC 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  322 RKREYKLENAKNKCRgnyengepkycsrngyDCKKTVRGKNilvsDTE---CTKCSVVCTPFVKWIDNQKEEFLKQKEKY 398
Cdd:PTZ00176  314 NVLNKEIDEMNNQCK----------------DCEMSRRCNN----DTEgekCKKCKEQCQIFKELVSKWKNQFDKQSMKY 373
                         410
                  ....*....|....*
gi 124015243  399 hKEIQKKedKTTTIT 413
Cdd:PTZ00176  374 -MELYNK--ASTNIT 385
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
852-1030 1.37e-51

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 180.55  E-value: 1.37e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   852 AYMPPRRQHMCTSNLENLDVDSVIKNdkasHSLLGDVLLSANHEAKKIKELYEKnkdqsgQNDKNGLTDDkTVCRAMKNS 931
Cdd:pfam05424    1 ACAPPRRLHLCVKNLEKINSGNTTTT----HDLLKAVILAAKYEGFSLWHKYKK------KNTKYGDIPS-EFCRQMAYS 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   932 FADIGDIIRGRDLWD-NKDQVTLQDHLKTIFGKIKGELKGEDKynrddkKSPPYKQLRADWWEANRDQIWEAMIC----- 1005
Cdd:pfam05424   70 FADIGDIIRGKDLYLgNNKKKKLEENLKKIFKKIYEKLTSKGK------DDGNYYQLREDWWEANREDIWKAMTCaltyg 143
                          170       180       190
                   ....*....|....*....|....*....|....*
gi 124015243  1006 ----------ETKSHPTIKCDKTTPYDDYIPQRLR 1030
Cdd:pfam05424  144 akyfrktcgdGISPSTAGCNDDVPTYFDYVPQFLR 178
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
816-1196 5.31e-50

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 196.79  E-value: 5.31e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  816 NGNNG-----EPCEGKDgsNKRFEIGTKWETG-----GTVQMTETEAYMPPRRQHMCTSNLENLdvdsVIKNDKASHSLL 885
Cdd:PTZ00176   77 NINNGypparNPCDGRN--QNRFDENGESYCNsdkirGNENNSNAGACAPFRRQNMCDKNLEYL----INKNTENTHDLL 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  886 GDVLLSANHEAKKIKELYeKNKDQSgqndkngltddkTVCRAMKNSFADIGDIIRGRDLWDNKDQVTLQDHLKTIFGKIK 965
Cdd:PTZ00176  151 GNVLVTAKYEGESIVNNH-PDKDKS------------SVCTALARSFADIGDIVRGKDMFKRNKHDNVENGLREVFKKIY 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  966 GELKGEDKYNR-DDKKSPPYKQLRADWWEANRDQIWEAMICETKSH------------------PTIKCDKTT--PYDDY 1024
Cdd:PTZ00176  218 EGLKNNGAREHyKEVKNGNYIKLREDWWTANRDQVWKAMTCVAPENayfrkteadgigisslilPYSKCGRDTdpPVVDY 297
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 1025 IPQRLRWMTEWAEWYCKAQTEAYGELLRDCGSCTGKVQCKEGTK--ECKDCKSSCEKYTEFVNKWKPQWNTMEIKYVPLY 1102
Cdd:PTZ00176  298 IPQRLRWMSEWSEYFCNVLNKEIDEMNNQCKDCEMSRRCNNDTEgeKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELY 377
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 1103 LQAKN--AYYGISFPGADY---------------QLMVDFLSKLHTSSVAAIGKNGETTNspyatpagyihqearvgKCL 1165
Cdd:PTZ00176  378 NKASTniTKQNSSAPERGYrrnhrrrgydddtnvQLFLKKVIENNECKVESLGKYLDKTS-----------------HCG 440
                         410       420       430
                  ....*....|....*....|....*....|..
gi 124015243 1166 EQNVFCDNN-GNNEKYAFKKTPPLYKYACECK 1196
Cdd:PTZ00176  441 NYNFNYDNTpGSNRSNAFEITPEKFKKACKCK 472
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
2169-2350 6.14e-43

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 155.89  E-value: 6.14e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2169 ACIPPRRQKLCVHYLKQ----SMTNTNELKYAFIKCAAAETFLLWQYYKSKNGNannldntliGGNIPEEFKRQMFYTFG 2244
Cdd:pfam05424    1 ACAPPRRLHLCVKNLEKinsgNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTK---------YGDIPSEFCRQMAYSFA 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2245 DYRDLCLDTDLSSKTDIHSAVsiaKDNIYKVFKKNYQTSIDH----------RKSWWETNGPVIWEGMLCALEK-ASGDK 2313
Cdd:pfam05424   72 DIGDIIRGKDLYLGNNKKKKL---EENLKKIFKKIYEKLTSKgkddgnyyqlREDWWEANREDIWKAMTCALTYgAKYFR 148
                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 124015243  2314 DKLIGDNSIYTyanvkFSGGDNPPTLekFAQRPQFLR 2350
Cdd:pfam05424  149 KTCGDGISPST-----AGCNDDVPTY--FDYVPQFLR 178
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
1307-1533 3.05e-34

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 130.86  E-value: 3.05e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  1307 ICIPPRRRKLYVTPLTKWENNSgsdtvvsgetlktsgTSSQSDktppastpatsstsstssqnatqLLTAFVESAAVETF 1386
Cdd:pfam05424    1 ACAPPRRLHLCVKNLEKINSGN---------------TTTTHD-----------------------LLKAVILAAKYEGF 42
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  1387 FLWDRYkkikekeieekrkrengglyiiikkkdilsdqdhPQNKLNRGEIPEEFKRQMFYTLADYKDILFSGskddntks 1466
Cdd:pfam05424   43 SLWHKY----------------------------------KKKNTKYGDIPSEFCRQMAYSFADIGDIIRGK-------- 80
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  1467 stynDILRGDKEiqerERKVKDAINNYFSNNGNKQP--PSSPPNSEKL-KSWWNNNAKHIWNAMVCALTY 1533
Cdd:pfam05424   81 ----DLYLGNNK----KKKLEENLKKIFKKIYEKLTskGKDDGNYYQLrEDWWEANREDIWKAMTCALTY 142
PFEMP pfam03011
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ...
590-734 4.13e-27

PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.


Pssm-ID: 281064  Cd Length: 154  Bit Score: 109.51  E-value: 4.13e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   590 LFLNWIDEMLKDSILWRKELDRCIKNEKESNCIRECKSKCDCFERWVEQKEQEWKQLEKHY-EEEDFSEDFGIEWTPYGT 668
Cdd:pfam03011    1 LFKRWVEYFLEDSIKWRKKLKSCINNGKGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFlKQYKLKGLTGKTLDEYLD 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124015243   669 LELYL-KNIYLEMIQKDYPQEKLVQEM-QTINEENSNDIFN---CTKENNSITKFLQHEAQEAKKCKENNP 734
Cdd:pfam03011   81 LKSFLeTFLFYIDIKEAYGDVKELKKLeEILDEEGCSAGAEsakNNKNEDAIDKLLDKEEKKANNCKEKHK 151
PFEMP pfam03011
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ...
1890-2037 4.54e-20

PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.


Pssm-ID: 281064  Cd Length: 154  Bit Score: 89.48  E-value: 4.54e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  1890 FLEYWLEDFIESYYILKKKklIEQCTKNG-GETCNENSKNGCACVKEWVEQKTTEWGDIKKHF----KIQNRENAFDIKY 1964
Cdd:pfam03011    1 LFKRWVEYFLEDSIKWRKK--LKSCINNGkGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFlkqyKLKGLTGKTLDEY 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124015243  1965 K-VETFLGDLIPRMDLTNGKEKIQELNKFLRSY-ECNCAENSPNGKESTPKDIVECLLTKLEDKANKCKTQTSGS 2037
Cdd:pfam03011   79 LdLKSFLETFLFYIDIKEAYGDVKELKKLEEILdEEGCSAGAESAKNNKNEDAIDKLLDKEEKKANNCKEKHKEN 153
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
2154-2492 1.26e-19

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 97.41  E-value: 1.26e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2154 EWTCDENKI----KIGQEGACIPPRRQKLCVHYLKQSMTNTNELKYAFIKcaaaeTFLLWQYYKSKNGNANNLDNTligg 2229
Cdd:PTZ00176  102 ESYCNSDKIrgneNNSNAGACAPFRRQNMCDKNLEYLINKNTENTHDLLG-----NVLVTAKYEGESIVNNHPDKD---- 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2230 niPEEFKRQMFYTFGDYRDLCLDTDLSSKTDihsavsiaKDNIYK----VFKKNYQTSIDH-----------------RK 2288
Cdd:PTZ00176  173 --KSSVCTALARSFADIGDIVRGKDMFKRNK--------HDNVENglreVFKKIYEGLKNNgarehykevkngnyiklRE 242
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2289 SWWETNGPVIWEGMLC-ALEKASGDKDKLIG---DNSIYTYAnvKFSGGDNPPTLEKFAQRpqfLRWMTEWGENFCKEQK 2364
Cdd:PTZ00176  243 DWWTANRDQVWKAMTCvAPENAYFRKTEADGigiSSLILPYS--KCGRDTDPPVVDYIPQR---LRWMSEWSEYFCNVLN 317
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2365 REYKVLLAKCKDCDVdgDGKCN-----GKCVACKKQCKEYQYWLEKWINNYKKQKGRY------------TQVKEIPL-- 2425
Cdd:PTZ00176  318 KEIDEMNNQCKDCEM--SRRCNndtegEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYmelynkastnitKQNSSAPErg 395
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124015243 2426 YKDDKDLQASDD---ARVYLDTQLKNMTCTNGS------TNENCEYKCMNKASSTNTDMPESLDEKPKKVKDKCNC 2492
Cdd:PTZ00176  396 YRRNHRRRGYDDdtnVQLFLKKVIENNECKVESlgkyldKTSHCGNYNFNYDNTPGSNRSNAFEITPEKFKKACKC 471
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
854-1115 4.23e-13

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 75.84  E-value: 4.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  854 MPPRRQHMCTSNLENLDVDSVIKNDKAShsllgDVLLSANHEAKKIKELYEKNKDQSGQndkngltddktvcrAMKNSFA 933
Cdd:PTZ00176  527 VPPRRRNLCINLFSKKDYKMKDENDFKE-----DLLNAAFSQGKLLGKKYSNYSNEAYE--------------AMKFSYA 587
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  934 DIGDIIRGRDLWDnkDQVTLQDHLKTIfgkIKGELKGEDKYNRDDkksppykqlradWWEANRDQIWEAMICETKSHPTI 1013
Cdd:PTZ00176  588 DYSDIVKGTDMMN--DLKKLNKELNTL---LKETEKGDISVDRKT------------WWDDNKNVVWNAMLCGYKTENEN 650
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 1014 KCDKTT----PYDDYIPQRLRWMTEWAEWYCKAQteaygeLLRdcgSCTGKVQCK---EGTKECK-------DCKSSCEK 1079
Cdd:PTZ00176  651 QQLNSSwcnvPDDDNIDQFLRWLTEWAQQYCKEK------LIK---AHIINTKCKdivEGRKHKSmvditdvECKRLFID 721
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 124015243 1080 YTEFVNKWKPQWNTMEIKYVPLYlQAKNAyyGISFP 1115
Cdd:PTZ00176  722 YEEWFRYRYNQWKGLSEKYIKIK-KSKNS--GVNIP 754
NTS pfam15447
N-terminal segments of PfEMP1; This family, the N-terminal segment, is the most variable part ...
17-52 7.29e-12

N-terminal segments of PfEMP1; This family, the N-terminal segment, is the most variable part of the variant surface antigen family of Plasmodium falciparum, the erythrocyte membrane protein-1 (PfEMP1) proteins. PfEMP1 is an important target for protective immunity and is implicated in the pathology of malaria through its ability to adhere to host endothelial receptors. A structural and functional study of the N-terminal domain of PfEMP1 from the VarO variant comprising the N-terminal segment (NTS) and the first DBL domain (DBL1alpha1), shows this region is directly implicated in rosetting. NTS, previously thought to be a structurally independent component of PfEMP1, forms an integral part of the DBL1alpha domain that is found to be the important heparin-binding site. This family is closely associated with PFEMP, pfam03011, and Duffy_binding, pfam05424.


Pssm-ID: 406013 [Multi-domain]  Cd Length: 36  Bit Score: 62.03  E-value: 7.29e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 124015243    17 DAKNLLDSIGKIVHDQVKNgEAQTYKEALKGDLQKA 52
Cdd:pfam15447    1 SAKHLLDRIGKDVHDKVKK-EAKRYKSELKGDLSKA 35
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
104-425 3.35e-11

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 69.68  E-value: 3.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  104 IKDSENNDNsiGACAPYRRLHLC-------DYnleKMGRTSTTKHDLLAEVCMAAKYEGgsikthytphqHKYGDSDSQI 176
Cdd:PTZ00176  515 VKNKENDNN--GVLVPPRRRNLCinlfskkDY---KMKDENDFKEDLLNAAFSQGKLLG-----------KKYSNYSNEA 578
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  177 CTVLARSFADIGDIIRGKDLyLGDKKKKQNEterekLEQKLKEifkkihsevTTNGELQKRygqdgqnfyqlREDWWYAN 256
Cdd:PTZ00176  579 YEAMKFSYADYSDIVKGTDM-MNDLKKLNKE-----LNTLLKE---------TEKGDISVD-----------RKTWWDDN 632
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  257 RETVWKAMTCEapesasyfRKTcdggENPTATQGNCKCingDVPTYfDYVPQYLRWFEEWAEDFCRKREYKLENAKNKCR 336
Cdd:PTZ00176  633 KNVVWNAMLCG--------YKT----ENENQQLNSSWC---NVPDD-DNIDQFLRWLTEWAQQYCKEKLIKAHIINTKCK 696
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  337 GNYENGEPKycsrngydckktvrgKNILVSDTECTKCSVvctPFVKWIDNQKEEFLKQKEKYhkeIQKKEDKTTTITIGD 416
Cdd:PTZ00176  697 DIVEGRKHK---------------SMVDITDVECKRLFI---DYEEWFRYRYNQWKGLSEKY---IKIKKSKNSGVNIPS 755

                  ....*....
gi 124015243  417 KTINNLYVS 425
Cdd:PTZ00176  756 EECAASYVT 764
CIDR1_gamma pfam18562
Cysteine-Rich Interdomain Region 1 gamma; Rosetting is the capacity of infected RBCs to bind ...
1814-1874 2.83e-09

Cysteine-Rich Interdomain Region 1 gamma; Rosetting is the capacity of infected RBCs to bind uninfected RBCs, which is consistently associated with severe malaria in African children. The rosette-forming PfEMP1 adhesins, namely IT4/R29, Palo Alto 89F5 VarO, 3D7/PF13_0003 and IT4/var60, belong to a specific sub-group called groupA/UpsA var genes and all four present a specific Duffy Binding-Like and and Cysteine-Rich Interdomain Region (DBL1alpha1-CIDR1gamma) double domain Head region found at the extracellular region of PfEMP1. This entry represents the CIDR1gamma domain which increases the binding affinity to VarO (Palo Alto VarO parasites).


Pssm-ID: 408346  Cd Length: 52  Bit Score: 54.97  E-value: 2.83e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124015243  1814 TANITVEMVDRRGPFIEKYLRNsktsqnslFKDSYLFKSVRNQNWTCKfNGENMDICKLTN 1874
Cdd:pfam18562    1 TTTIDMLVSDNRGIKFENDLKE--------CKEAGIFKGIRKDQWKCG-KVCGYDVCKLKN 52
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
1471-1769 1.32e-03

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 44.64  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 1471 DILRG--------DKEIQERERKVKDAINNYFSNNGNKQ--PPSSPPNSEKLKS-WWNNNAKHIWNAMVC-----ALTYK 1534
Cdd:PTZ00176  189 DIVRGkdmfkrnkHDNVENGLREVFKKIYEGLKNNGAREhyKEVKNGNYIKLREdWWTANRDQVWKAMTCvapenAYFRK 268
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 1535 ENGSGGDgkttitqdeslkeqllengkqpkqngthdytYENVVLkdensdtrPKTTGGEKTTlntPKLRDFveIPTFFRY 1614
Cdd:PTZ00176  269 TEADGIG-------------------------------ISSLIL--------PYSKCGRDTD---PPVVDY--IPQRLRW 304
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 1615 LHEWGEEFCRKRKDKFKKLDKECRgvnnsgdpkycsgdghDCEKnSLKHHKMFEDSLCSGCYEQCRKYR----KW---ID 1687
Cdd:PTZ00176  305 MSEWSEYFCNVLNKEIDEMNNQCK----------------DCEM-SRRCNNDTEGEKCKKCKEQCQIFKelvsKWknqFD 367
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 1688 IKFVEYHKQEKKYEEEKQKLNGNSNNEVY---------------QKFYEQIKEK-----KTAAGFLQSLKHCKN---NEG 1744
Cdd:PTZ00176  368 KQSMKYMELYNKASTNITKQNSSAPERGYrrnhrrrgydddtnvQLFLKKVIENneckvESLGKYLDKTSHCGNynfNYD 447
                         330       340
                  ....*....|....*....|....*
gi 124015243 1745 DGSDPNNKISFENPLETFNPSTYCK 1769
Cdd:PTZ00176  448 NTPGSNRSNAFEITPEKFKKACKCK 472
 
Name Accession Description Interval E-value
ATS pfam15445
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and ...
2548-2975 0e+00

acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and relatively conserved acidic terminal segment of the Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1). this domain appears to be present in all variants of the highly polymorphic PfEMP1 proteins.


Pssm-ID: 373851 [Multi-domain]  Cd Length: 446  Bit Score: 751.25  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2548 TIPIGISLALGSIAFLFIKKKTKSSVGNLFQILQIPKSDYNIPTLKSKNRYIPYRSGTYKGKTYIYMEGDSSGDEKYAFM 2627
Cdd:pfam15445    1 TIPWSVGIAFAAFTYFFLKKKTKSSVGNLFQILQIPKGDYDIPTLKSKNRYIPYASDRYKGKTYIYMEGDSSGDEKYAFM 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2628 SDTTDVTSSESEYEELDISDIYVPGSPKYKTLIEVVLEPSGNNTtasdkNTPSDTQNDIQNDGIPSS-KITDNEWNTLKD 2706
Cdd:pfam15445   81 SDTTDITSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSKNNT-----NTPSDTQNDIPSDDIPSTnKITDEEWNTLKH 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2707 EFISQYLQSEPLDVPNDYSSRDIPFNTQPSTLYFDNNQEKPFITSIHDRNLYSGEEYN--YNVNMVNNDDIPINRDNNVY 2784
Cdd:pfam15445  156 DFISNMLQNTQNDEPNILHSGNVPNNTHPNTLSRDNMEEKPFIMSIHDRNLYTGEEYSynINMSTNSMDDIPKYVSNNVY 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2785 SGIDLINDALNGD--YDIYDEILKRKENELFGTNHTKHTTTNRVATQICDGPITNQLNLFHRWLDRHRNMCEQWNNKEDI 2862
Cdd:pfam15445  236 SGIDLINDTLSGNqhIDIYDEVLKRKENELFGTNHTKHTSTNSVAKNTNSDPILNQLNLFHKWLDRHRDMCEKWKNKEER 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2863 LNKLNEEWNKDNDRA-------NVPNDNKTLNTDVSIQIHMDNPKPINEFTN---------MDTILDDLEKYNEPYYDV- 2925
Cdd:pfam15445  316 LDKLKEEWNKENNHSgdihpsdDIPSDNKVLNTDVSIQIDMDNPKPKNEFTNmdtnpdnstMDTILDDLEKYNEPYYDIy 395
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 124015243  2926 QDDIYYDVHDHDASTVDTNAMDVPSKVQIEMDVNT-KLVKEKYPISDVWDI 2975
Cdd:pfam15445  396 EDDIYYDVNDHDASTVDSNNMDVPSKVQIEMDVNNtKLVEEKYPISDVWNI 446
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
2149-2975 8.04e-166

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 551.56  E-value: 8.04e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2149 KETYSEWTCDENKIKIG-QEGACIPPRRQKLCVHYLKQS---MTNTNELKYAFIKCAAAETFLLWQYYKskngnannldn 2224
Cdd:PTZ00176  504 KNDLSEWNNSGVKNKENdNNGVLVPPRRRNLCINLFSKKdykMKDENDFKEDLLNAAFSQGKLLGKKYS----------- 572
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2225 tliggNIPEEFKRQMFYTFGDYRDLCLDTDLSSKTdihSAVSIAKDNIYKVFKKNyQTSIDhRKSWWETNGPVIWEGMLC 2304
Cdd:PTZ00176  573 -----NYSNEAYEAMKFSYADYSDIVKGTDMMNDL---KKLNKELNTLLKETEKG-DISVD-RKTWWDDNKNVVWNAMLC 642
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2305 ALeKASGDKDKLigdNSiyTYANVkfSGGDNPPtlekfaqrpQFLRWMTEWGENFCKEQKREYKVLLAKCKDCdVDG--- 2381
Cdd:PTZ00176  643 GY-KTENENQQL---NS--SWCNV--PDDDNID---------QFLRWLTEWAQQYCKEKLIKAHIINTKCKDI-VEGrkh 704
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2382 DGKCNGKCVACKKQCKEYQYWLEKWINNYKKQKGRYTQVKEIPlyKDDKDLQASDDARVYLDTQLKNMTCT--------N 2453
Cdd:PTZ00176  705 KSMVDITDVECKRLFIDYEEWFRYRYNQWKGLSEKYIKIKKSK--NSGVNIPSEECAASYVTKHCNGCICNlrdmedihK 782
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2454 GSTNENCEYKCMNKASSTNTD--------MPESLDEKPKKVKDKCNCIRDECS-GLSvtgsGFSHVSAFGGGVPEPKCKG 2524
Cdd:PTZ00176  783 NINNQNELMKEMINIIKFDTDqyrtqlqnISNSMEINPKSVKTAVDTTKDIVSyGLA----GTMGVAAIGLQAGDFLGKK 858
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2525 FEEHLPKKMEP--PQYDPTNDILKT------TIPIGISLALGSIAFLF-IKKKTKSSVgNLFQILQIPKSDYNIPTLKSK 2595
Cdd:PTZ00176  859 IQDLYNEFMKPveKKLDTSSKNLNIyedpniMVPAGIGVALTLGLLLFkMRRKAKRQV-DMIRILQMSQNEYGIPTTKSP 937
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2596 NRYIPYRSGTYKGKTYIYMEGDSSgDEKYAFMSDTTDVTSSESEYEELDISDIYVPGSPKYKTLIEVVLEPSgnnttasd 2675
Cdd:PTZ00176  938 NKYVPYGSQRYKGKTYLYVEGDTD-EEKYMFMSDTTDITSSESEYEEMDINDIYVPGSPKYKTLIEVVLEPS-------- 1008
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2676 kntPSDTQNDIQNDGIPSSKITDNEWNTLKDEFISQYLQSEPLDvpNDYSSRDIPFNTQPSTLYFDNNQEKPFITSIHDR 2755
Cdd:PTZ00176 1009 ---KRDTQNDIPSDNTPSYKLTDEEWNQLKDDFISQYLPNTEPN--NNYRSGNSPTNTNNTTTSHDNMGEKPFIMSIHDR 1083
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2756 NLYSGEEYNYN-VNMVNNDDIPINRDNNVYSGIDLINDALNGD--YDIYDEILKRKENELFGTNHTKHTTTNRVA-TQIC 2831
Cdd:PTZ00176 1084 NLYTGEEISYNiNMSTNTMDDPKYVSNNVYSGIDLINDTLSGNqhIDIYDEVLKRKENELFGTNHVKQTSIHSVAkNTYS 1163
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2832 DGPITNQLNLFHRWLDRHRNMCEQWNNKEDILNKLNEEWNKDNDRANVPNDNKTLNTDVSIQIHMDNPKPINEFTNMDTI 2911
Cdd:PTZ00176 1164 DDAITNKINLFHKWLDRHRDMCEKWENHHERLAKLKEKWENDNDGGNVPSDNHVLNTDVSIEIDMDNPKPINQFSNMDIN 1243
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124015243 2912 LDdlekyNEPYYDVQDDIYYDVHDHDAS---------TVDTNA--MDVPSKVQIEMDV--NTK--LVKEKYPISDVWDI 2975
Cdd:PTZ00176 1244 VD-----TPTMDNMEDDIYYDVNDNDDDndqpsvydiPMDHNKvdVDVPKKVHIEMKIlnNTSngSLEQQFPISDVWNI 1317
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
116-311 1.28e-88

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 286.48  E-value: 1.28e-88
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   116 ACAPYRRLHLCDYNLEKMGRT-STTKHDLLAEVCMAAKYEGGSIKTHYTPHQHKYGDSDSQICTVLARSFADIGDIIRGK 194
Cdd:pfam05424    1 ACAPPRRLHLCVKNLEKINSGnTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTKYGDIPSEFCRQMAYSFADIGDIIRGK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   195 DLYLGDKKKKqnetereKLEQKLKEIFKKIHSEVTTNgelqkryGQDGQNFYQLREDWWYANRETVWKAMTCEAPESASY 274
Cdd:pfam05424   81 DLYLGNNKKK-------KLEENLKKIFKKIYEKLTSK-------GKDDGNYYQLREDWWEANREDIWKAMTCALTYGAKY 146
                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 124015243   275 FRKTCDGGENPTATqgnckCINGDVPTYFDYVPQYLR 311
Cdd:pfam05424  147 FRKTCGDGISPSTA-----GCNDDVPTYFDYVPQFLR 178
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
16-413 2.28e-67

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 252.65  E-value: 2.28e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   16 KDAKNLLDSIGKIVHDQVKNgeAQTYKEALKGDLQKA---NGIGE-----RASSNKTCDLVQEYYGRADN---SNRYPCA 84
Cdd:PTZ00176   13 LSARNVLENIGNEIKDKREN--ESKYTDKLKGSLWEArfsDGLSSsfgdvRSGYYDSCSLDHKFHTNINNgypPARNPCD 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   85 NRQTVRFSDEYGGQCTYNRIKDSENNDNSiGACAPYRRLHLCDYNLEKMGRTST-TKHDLLAEVCMAAKYEGGSIKTHYt 163
Cdd:PTZ00176   91 GRNQNRFDENGESYCNSDKIRGNENNSNA-GACAPFRRQNMCDKNLEYLINKNTeNTHDLLGNVLVTAKYEGESIVNNH- 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  164 PHQHKygdsdSQICTVLARSFADIGDIIRGKDLYlgdKKKKQNEterekLEQKLKEIFKKIHSEVTTNGeLQKRYGQDGQ 243
Cdd:PTZ00176  169 PDKDK-----SSVCTALARSFADIGDIVRGKDMF---KRNKHDN-----VENGLREVFKKIYEGLKNNG-AREHYKEVKN 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  244 -NFYQLREDWWYANRETVWKAMTCEAPESAsYFRKT-CDGGENPTATQGNCKCINGDVPTYFDYVPQYLRWFEEWAEDFC 321
Cdd:PTZ00176  235 gNYIKLREDWWTANRDQVWKAMTCVAPENA-YFRKTeADGIGISSLILPYSKCGRDTDPPVVDYIPQRLRWMSEWSEYFC 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  322 RKREYKLENAKNKCRgnyengepkycsrngyDCKKTVRGKNilvsDTE---CTKCSVVCTPFVKWIDNQKEEFLKQKEKY 398
Cdd:PTZ00176  314 NVLNKEIDEMNNQCK----------------DCEMSRRCNN----DTEgekCKKCKEQCQIFKELVSKWKNQFDKQSMKY 373
                         410
                  ....*....|....*
gi 124015243  399 hKEIQKKedKTTTIT 413
Cdd:PTZ00176  374 -MELYNK--ASTNIT 385
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
852-1030 1.37e-51

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 180.55  E-value: 1.37e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   852 AYMPPRRQHMCTSNLENLDVDSVIKNdkasHSLLGDVLLSANHEAKKIKELYEKnkdqsgQNDKNGLTDDkTVCRAMKNS 931
Cdd:pfam05424    1 ACAPPRRLHLCVKNLEKINSGNTTTT----HDLLKAVILAAKYEGFSLWHKYKK------KNTKYGDIPS-EFCRQMAYS 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   932 FADIGDIIRGRDLWD-NKDQVTLQDHLKTIFGKIKGELKGEDKynrddkKSPPYKQLRADWWEANRDQIWEAMIC----- 1005
Cdd:pfam05424   70 FADIGDIIRGKDLYLgNNKKKKLEENLKKIFKKIYEKLTSKGK------DDGNYYQLREDWWEANREDIWKAMTCaltyg 143
                          170       180       190
                   ....*....|....*....|....*....|....*
gi 124015243  1006 ----------ETKSHPTIKCDKTTPYDDYIPQRLR 1030
Cdd:pfam05424  144 akyfrktcgdGISPSTAGCNDDVPTYFDYVPQFLR 178
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
816-1196 5.31e-50

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 196.79  E-value: 5.31e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  816 NGNNG-----EPCEGKDgsNKRFEIGTKWETG-----GTVQMTETEAYMPPRRQHMCTSNLENLdvdsVIKNDKASHSLL 885
Cdd:PTZ00176   77 NINNGypparNPCDGRN--QNRFDENGESYCNsdkirGNENNSNAGACAPFRRQNMCDKNLEYL----INKNTENTHDLL 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  886 GDVLLSANHEAKKIKELYeKNKDQSgqndkngltddkTVCRAMKNSFADIGDIIRGRDLWDNKDQVTLQDHLKTIFGKIK 965
Cdd:PTZ00176  151 GNVLVTAKYEGESIVNNH-PDKDKS------------SVCTALARSFADIGDIVRGKDMFKRNKHDNVENGLREVFKKIY 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  966 GELKGEDKYNR-DDKKSPPYKQLRADWWEANRDQIWEAMICETKSH------------------PTIKCDKTT--PYDDY 1024
Cdd:PTZ00176  218 EGLKNNGAREHyKEVKNGNYIKLREDWWTANRDQVWKAMTCVAPENayfrkteadgigisslilPYSKCGRDTdpPVVDY 297
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 1025 IPQRLRWMTEWAEWYCKAQTEAYGELLRDCGSCTGKVQCKEGTK--ECKDCKSSCEKYTEFVNKWKPQWNTMEIKYVPLY 1102
Cdd:PTZ00176  298 IPQRLRWMSEWSEYFCNVLNKEIDEMNNQCKDCEMSRRCNNDTEgeKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELY 377
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 1103 LQAKN--AYYGISFPGADY---------------QLMVDFLSKLHTSSVAAIGKNGETTNspyatpagyihqearvgKCL 1165
Cdd:PTZ00176  378 NKASTniTKQNSSAPERGYrrnhrrrgydddtnvQLFLKKVIENNECKVESLGKYLDKTS-----------------HCG 440
                         410       420       430
                  ....*....|....*....|....*....|..
gi 124015243 1166 EQNVFCDNN-GNNEKYAFKKTPPLYKYACECK 1196
Cdd:PTZ00176  441 NYNFNYDNTpGSNRSNAFEITPEKFKKACKCK 472
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
2169-2350 6.14e-43

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 155.89  E-value: 6.14e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2169 ACIPPRRQKLCVHYLKQ----SMTNTNELKYAFIKCAAAETFLLWQYYKSKNGNannldntliGGNIPEEFKRQMFYTFG 2244
Cdd:pfam05424    1 ACAPPRRLHLCVKNLEKinsgNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTK---------YGDIPSEFCRQMAYSFA 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  2245 DYRDLCLDTDLSSKTDIHSAVsiaKDNIYKVFKKNYQTSIDH----------RKSWWETNGPVIWEGMLCALEK-ASGDK 2313
Cdd:pfam05424   72 DIGDIIRGKDLYLGNNKKKKL---EENLKKIFKKIYEKLTSKgkddgnyyqlREDWWEANREDIWKAMTCALTYgAKYFR 148
                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 124015243  2314 DKLIGDNSIYTyanvkFSGGDNPPTLekFAQRPQFLR 2350
Cdd:pfam05424  149 KTCGDGISPST-----AGCNDDVPTY--FDYVPQFLR 178
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
1307-1533 3.05e-34

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 130.86  E-value: 3.05e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  1307 ICIPPRRRKLYVTPLTKWENNSgsdtvvsgetlktsgTSSQSDktppastpatsstsstssqnatqLLTAFVESAAVETF 1386
Cdd:pfam05424    1 ACAPPRRLHLCVKNLEKINSGN---------------TTTTHD-----------------------LLKAVILAAKYEGF 42
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  1387 FLWDRYkkikekeieekrkrengglyiiikkkdilsdqdhPQNKLNRGEIPEEFKRQMFYTLADYKDILFSGskddntks 1466
Cdd:pfam05424   43 SLWHKY----------------------------------KKKNTKYGDIPSEFCRQMAYSFADIGDIIRGK-------- 80
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  1467 stynDILRGDKEiqerERKVKDAINNYFSNNGNKQP--PSSPPNSEKL-KSWWNNNAKHIWNAMVCALTY 1533
Cdd:pfam05424   81 ----DLYLGNNK----KKKLEENLKKIFKKIYEKLTskGKDDGNYYQLrEDWWEANREDIWKAMTCALTY 142
PFEMP pfam03011
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ...
590-734 4.13e-27

PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.


Pssm-ID: 281064  Cd Length: 154  Bit Score: 109.51  E-value: 4.13e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243   590 LFLNWIDEMLKDSILWRKELDRCIKNEKESNCIRECKSKCDCFERWVEQKEQEWKQLEKHY-EEEDFSEDFGIEWTPYGT 668
Cdd:pfam03011    1 LFKRWVEYFLEDSIKWRKKLKSCINNGKGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFlKQYKLKGLTGKTLDEYLD 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124015243   669 LELYL-KNIYLEMIQKDYPQEKLVQEM-QTINEENSNDIFN---CTKENNSITKFLQHEAQEAKKCKENNP 734
Cdd:pfam03011   81 LKSFLeTFLFYIDIKEAYGDVKELKKLeEILDEEGCSAGAEsakNNKNEDAIDKLLDKEEKKANNCKEKHK 151
PFEMP pfam03011
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ...
1890-2037 4.54e-20

PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.


Pssm-ID: 281064  Cd Length: 154  Bit Score: 89.48  E-value: 4.54e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  1890 FLEYWLEDFIESYYILKKKklIEQCTKNG-GETCNENSKNGCACVKEWVEQKTTEWGDIKKHF----KIQNRENAFDIKY 1964
Cdd:pfam03011    1 LFKRWVEYFLEDSIKWRKK--LKSCINNGkGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFlkqyKLKGLTGKTLDEY 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124015243  1965 K-VETFLGDLIPRMDLTNGKEKIQELNKFLRSY-ECNCAENSPNGKESTPKDIVECLLTKLEDKANKCKTQTSGS 2037
Cdd:pfam03011   79 LdLKSFLETFLFYIDIKEAYGDVKELKKLEEILdEEGCSAGAESAKNNKNEDAIDKLLDKEEKKANNCKEKHKEN 153
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
2154-2492 1.26e-19

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 97.41  E-value: 1.26e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2154 EWTCDENKI----KIGQEGACIPPRRQKLCVHYLKQSMTNTNELKYAFIKcaaaeTFLLWQYYKSKNGNANNLDNTligg 2229
Cdd:PTZ00176  102 ESYCNSDKIrgneNNSNAGACAPFRRQNMCDKNLEYLINKNTENTHDLLG-----NVLVTAKYEGESIVNNHPDKD---- 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2230 niPEEFKRQMFYTFGDYRDLCLDTDLSSKTDihsavsiaKDNIYK----VFKKNYQTSIDH-----------------RK 2288
Cdd:PTZ00176  173 --KSSVCTALARSFADIGDIVRGKDMFKRNK--------HDNVENglreVFKKIYEGLKNNgarehykevkngnyiklRE 242
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2289 SWWETNGPVIWEGMLC-ALEKASGDKDKLIG---DNSIYTYAnvKFSGGDNPPTLEKFAQRpqfLRWMTEWGENFCKEQK 2364
Cdd:PTZ00176  243 DWWTANRDQVWKAMTCvAPENAYFRKTEADGigiSSLILPYS--KCGRDTDPPVVDYIPQR---LRWMSEWSEYFCNVLN 317
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 2365 REYKVLLAKCKDCDVdgDGKCN-----GKCVACKKQCKEYQYWLEKWINNYKKQKGRY------------TQVKEIPL-- 2425
Cdd:PTZ00176  318 KEIDEMNNQCKDCEM--SRRCNndtegEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYmelynkastnitKQNSSAPErg 395
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124015243 2426 YKDDKDLQASDD---ARVYLDTQLKNMTCTNGS------TNENCEYKCMNKASSTNTDMPESLDEKPKKVKDKCNC 2492
Cdd:PTZ00176  396 YRRNHRRRGYDDdtnVQLFLKKVIENNECKVESlgkyldKTSHCGNYNFNYDNTPGSNRSNAFEITPEKFKKACKC 471
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
854-1115 4.23e-13

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 75.84  E-value: 4.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  854 MPPRRQHMCTSNLENLDVDSVIKNDKAShsllgDVLLSANHEAKKIKELYEKNKDQSGQndkngltddktvcrAMKNSFA 933
Cdd:PTZ00176  527 VPPRRRNLCINLFSKKDYKMKDENDFKE-----DLLNAAFSQGKLLGKKYSNYSNEAYE--------------AMKFSYA 587
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  934 DIGDIIRGRDLWDnkDQVTLQDHLKTIfgkIKGELKGEDKYNRDDkksppykqlradWWEANRDQIWEAMICETKSHPTI 1013
Cdd:PTZ00176  588 DYSDIVKGTDMMN--DLKKLNKELNTL---LKETEKGDISVDRKT------------WWDDNKNVVWNAMLCGYKTENEN 650
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 1014 KCDKTT----PYDDYIPQRLRWMTEWAEWYCKAQteaygeLLRdcgSCTGKVQCK---EGTKECK-------DCKSSCEK 1079
Cdd:PTZ00176  651 QQLNSSwcnvPDDDNIDQFLRWLTEWAQQYCKEK------LIK---AHIINTKCKdivEGRKHKSmvditdvECKRLFID 721
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 124015243 1080 YTEFVNKWKPQWNTMEIKYVPLYlQAKNAyyGISFP 1115
Cdd:PTZ00176  722 YEEWFRYRYNQWKGLSEKYIKIK-KSKNS--GVNIP 754
NTS pfam15447
N-terminal segments of PfEMP1; This family, the N-terminal segment, is the most variable part ...
17-52 7.29e-12

N-terminal segments of PfEMP1; This family, the N-terminal segment, is the most variable part of the variant surface antigen family of Plasmodium falciparum, the erythrocyte membrane protein-1 (PfEMP1) proteins. PfEMP1 is an important target for protective immunity and is implicated in the pathology of malaria through its ability to adhere to host endothelial receptors. A structural and functional study of the N-terminal domain of PfEMP1 from the VarO variant comprising the N-terminal segment (NTS) and the first DBL domain (DBL1alpha1), shows this region is directly implicated in rosetting. NTS, previously thought to be a structurally independent component of PfEMP1, forms an integral part of the DBL1alpha domain that is found to be the important heparin-binding site. This family is closely associated with PFEMP, pfam03011, and Duffy_binding, pfam05424.


Pssm-ID: 406013 [Multi-domain]  Cd Length: 36  Bit Score: 62.03  E-value: 7.29e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 124015243    17 DAKNLLDSIGKIVHDQVKNgEAQTYKEALKGDLQKA 52
Cdd:pfam15447    1 SAKHLLDRIGKDVHDKVKK-EAKRYKSELKGDLSKA 35
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
104-425 3.35e-11

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 69.68  E-value: 3.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  104 IKDSENNDNsiGACAPYRRLHLC-------DYnleKMGRTSTTKHDLLAEVCMAAKYEGgsikthytphqHKYGDSDSQI 176
Cdd:PTZ00176  515 VKNKENDNN--GVLVPPRRRNLCinlfskkDY---KMKDENDFKEDLLNAAFSQGKLLG-----------KKYSNYSNEA 578
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  177 CTVLARSFADIGDIIRGKDLyLGDKKKKQNEterekLEQKLKEifkkihsevTTNGELQKRygqdgqnfyqlREDWWYAN 256
Cdd:PTZ00176  579 YEAMKFSYADYSDIVKGTDM-MNDLKKLNKE-----LNTLLKE---------TEKGDISVD-----------RKTWWDDN 632
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  257 RETVWKAMTCEapesasyfRKTcdggENPTATQGNCKCingDVPTYfDYVPQYLRWFEEWAEDFCRKREYKLENAKNKCR 336
Cdd:PTZ00176  633 KNVVWNAMLCG--------YKT----ENENQQLNSSWC---NVPDD-DNIDQFLRWLTEWAQQYCKEKLIKAHIINTKCK 696
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243  337 GNYENGEPKycsrngydckktvrgKNILVSDTECTKCSVvctPFVKWIDNQKEEFLKQKEKYhkeIQKKEDKTTTITIGD 416
Cdd:PTZ00176  697 DIVEGRKHK---------------SMVDITDVECKRLFI---DYEEWFRYRYNQWKGLSEKY---IKIKKSKNSGVNIPS 755

                  ....*....
gi 124015243  417 KTINNLYVS 425
Cdd:PTZ00176  756 EECAASYVT 764
CIDR1_gamma pfam18562
Cysteine-Rich Interdomain Region 1 gamma; Rosetting is the capacity of infected RBCs to bind ...
1814-1874 2.83e-09

Cysteine-Rich Interdomain Region 1 gamma; Rosetting is the capacity of infected RBCs to bind uninfected RBCs, which is consistently associated with severe malaria in African children. The rosette-forming PfEMP1 adhesins, namely IT4/R29, Palo Alto 89F5 VarO, 3D7/PF13_0003 and IT4/var60, belong to a specific sub-group called groupA/UpsA var genes and all four present a specific Duffy Binding-Like and and Cysteine-Rich Interdomain Region (DBL1alpha1-CIDR1gamma) double domain Head region found at the extracellular region of PfEMP1. This entry represents the CIDR1gamma domain which increases the binding affinity to VarO (Palo Alto VarO parasites).


Pssm-ID: 408346  Cd Length: 52  Bit Score: 54.97  E-value: 2.83e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124015243  1814 TANITVEMVDRRGPFIEKYLRNsktsqnslFKDSYLFKSVRNQNWTCKfNGENMDICKLTN 1874
Cdd:pfam18562    1 TTTIDMLVSDNRGIKFENDLKE--------CKEAGIFKGIRKDQWKCG-KVCGYDVCKLKN 52
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
1471-1769 1.32e-03

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 44.64  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 1471 DILRG--------DKEIQERERKVKDAINNYFSNNGNKQ--PPSSPPNSEKLKS-WWNNNAKHIWNAMVC-----ALTYK 1534
Cdd:PTZ00176  189 DIVRGkdmfkrnkHDNVENGLREVFKKIYEGLKNNGAREhyKEVKNGNYIKLREdWWTANRDQVWKAMTCvapenAYFRK 268
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 1535 ENGSGGDgkttitqdeslkeqllengkqpkqngthdytYENVVLkdensdtrPKTTGGEKTTlntPKLRDFveIPTFFRY 1614
Cdd:PTZ00176  269 TEADGIG-------------------------------ISSLIL--------PYSKCGRDTD---PPVVDY--IPQRLRW 304
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 1615 LHEWGEEFCRKRKDKFKKLDKECRgvnnsgdpkycsgdghDCEKnSLKHHKMFEDSLCSGCYEQCRKYR----KW---ID 1687
Cdd:PTZ00176  305 MSEWSEYFCNVLNKEIDEMNNQCK----------------DCEM-SRRCNNDTEGEKCKKCKEQCQIFKelvsKWknqFD 367
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124015243 1688 IKFVEYHKQEKKYEEEKQKLNGNSNNEVY---------------QKFYEQIKEK-----KTAAGFLQSLKHCKN---NEG 1744
Cdd:PTZ00176  368 KQSMKYMELYNKASTNITKQNSSAPERGYrrnhrrrgydddtnvQLFLKKVIENneckvESLGKYLDKTSHCGNynfNYD 447
                         330       340
                  ....*....|....*....|....*
gi 124015243 1745 DGSDPNNKISFENPLETFNPSTYCK 1769
Cdd:PTZ00176  448 NTPGSNRSNAFEITPEKFKKACKCK 472
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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