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Conserved domains on  [gi|123794889|sp|Q3UPW2|]
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RecName: Full=ETS-related transcription factor Elf-3; AltName: Full=E74-like factor 3; AltName: Full=Epithelial-restricted with serine box; AltName: Full=Epithelium-restricted Ets protein ESX; AltName: Full=Epithelium-specific Ets transcription factor 1; Short=ESE-1

Protein Classification

SAM domain-containing protein( domain architecture ID 10170775)

SAM (sterile alpha motif) domain-containing protein may be involved in protein-protein interaction and in developmental regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 292-379 1.34e-43

erythroblast transformation specific domain; variation of the helix-turn-helix motif


:

Pssm-ID: 197710  Cd Length: 87  Bit Score: 146.26  E-value: 1.34e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123794889   292 GTHLWEFIRDILIHPElNEGLMKWENRHEGVFKFLRSEAVAQLWGQKKKNSNMTYEKLSRAMRYYYKREILERVDGRRLV 371
Cdd:smart00413   1 GIQLWQFLLDLLLDPE-NSDIIKWTDRDEGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLV 79


                   ....*...
gi 123794889   372 YKFGKNSS 379
Cdd:smart00413  80 YKFVKNPL 87
SAM_PNT-ESE-1-like cd08537
Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators; SAM ...
 74-151 6.09e-42

Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators; SAM Pointed domain of ESE-1-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. SAM Pointed domain of ESE-1 provides a potential docking site for signaling kinase Pak1 in humans. ESE-1 factors are involved in regulation of gene expression in different types of epithelial cells. ESE-1 is expressed in many different organs including intestine, stomach, pancreas, lungs, kidneys, and prostate. The DNA binding consensus motif for ESE-1 consists of a purine-rich GGA[AT] core sequence. The expression profile of these factors is altered in epithelial cancers if compared to normal tissues. Members of this subfamily are potential targets for cancer therapy.


:

Pssm-ID: 188880  Cd Length: 81  Bit Score: 141.90  E-value: 6.09e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 123794889  74 EKASWTSERPQFWSKTQVLEWISYQVEKNKYDASSIDFSRCDMDGATLCSCALEELRLVFGP-LGDQLHAQLRDLTSNS 151
Cdd:cd08537    3 TKGSWDQENPQFWSKQNVLEWISYHVEKNKYDASSLDLSYCTMDGLTLCACAKEQLMLVFGPeLGDLLHHSLEELTSRY 81
 
Name Accession Description Interval E-value
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 292-379 1.34e-43

erythroblast transformation specific domain; variation of the helix-turn-helix motif


Pssm-ID: 197710  Cd Length: 87  Bit Score: 146.26  E-value: 1.34e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123794889   292 GTHLWEFIRDILIHPElNEGLMKWENRHEGVFKFLRSEAVAQLWGQKKKNSNMTYEKLSRAMRYYYKREILERVDGRRLV 371
Cdd:smart00413   1 GIQLWQFLLDLLLDPE-NSDIIKWTDRDEGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLV 79


                   ....*...
gi 123794889   372 YKFGKNSS 379
Cdd:smart00413  80 YKFVKNPL 87
SAM_PNT-ESE-1-like cd08537
Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators; SAM ...
 74-151 6.09e-42

Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators; SAM Pointed domain of ESE-1-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. SAM Pointed domain of ESE-1 provides a potential docking site for signaling kinase Pak1 in humans. ESE-1 factors are involved in regulation of gene expression in different types of epithelial cells. ESE-1 is expressed in many different organs including intestine, stomach, pancreas, lungs, kidneys, and prostate. The DNA binding consensus motif for ESE-1 consists of a purine-rich GGA[AT] core sequence. The expression profile of these factors is altered in epithelial cancers if compared to normal tissues. Members of this subfamily are potential targets for cancer therapy.


Pssm-ID: 188880  Cd Length: 81  Bit Score: 141.90  E-value: 6.09e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 123794889  74 EKASWTSERPQFWSKTQVLEWISYQVEKNKYDASSIDFSRCDMDGATLCSCALEELRLVFGP-LGDQLHAQLRDLTSNS 151
Cdd:cd08537    3 TKGSWDQENPQFWSKQNVLEWISYHVEKNKYDASSLDLSYCTMDGLTLCACAKEQLMLVFGPeLGDLLHHSLEELTSRY 81
Ets pfam00178
Ets-domain;
294-374 2.57e-37

Ets-domain;


Pssm-ID: 459700  Cd Length: 80  Bit Score: 129.92  E-value: 2.57e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123794889  294 HLWEFIRDILIHPElNEGLMKWENRHEGVFKFLRSEAVAQLWGQKKKNSNMTYEKLSRAMRYYYKREILERVDGRRLVYK 373
Cdd:pfam00178   1 QLWQFLLDLLTDPE-YSDIIKWTDKEEGEFRLVDPEAVARLWGKRKGNPKMTYEKLSRALRYYYKKGILEKVPGKRLTYR 79


                  .
gi 123794889  374 F 374
Cdd:pfam00178  80 F 80
SAM_PNT pfam02198
Sterile alpha motif (SAM)/Pointed domain;
67-151 5.03e-26

Sterile alpha motif (SAM)/Pointed domain;


Pssm-ID: 460486  Cd Length: 83  Bit Score: 100.05  E-value: 5.03e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123794889   67 LAVLHLAEKASWTSERPQFWSKTQVLEWISYQVekNKYDASSIDFSRCDMDGATLCSCALEELRLVFGPLGDQLHAQLRD 146
Cdd:pfam02198   1 LPSFEKEQLRLWIPADPRLWTKDHVLEWLEWAV--DEFDLSKIDFSQFDMNGKALCSLGKEEFLQRAPGPGDILWSHLQI 78


                  ....*
gi 123794889  147 LTSNS 151
Cdd:pfam02198  79 LRKAS 83
SAM_PNT smart00251
SAM / Pointed domain; A subfamily of the SAM domain
 72-150 7.89e-24

SAM / Pointed domain; A subfamily of the SAM domain


Pssm-ID: 128547  Cd Length: 82  Bit Score: 93.87  E-value: 7.89e-24
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 123794889    72 LAEKASWTSERPQFWSKTQVLEWISYQVekNKYDASSIDFSRCDMDGATLCSCALEELRLVFGPLGDQLHAQLRDLTSN 150
Cdd:smart00251   6 KEQKRLGIPADPQLWTEDHVLEWLEWAV--KEFSLSPIDFSKFDMSGKELCSMSKEEFLERAPFGGDILWSHLQILRKA 82
 
Name Accession Description Interval E-value
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 292-379 1.34e-43

erythroblast transformation specific domain; variation of the helix-turn-helix motif


Pssm-ID: 197710  Cd Length: 87  Bit Score: 146.26  E-value: 1.34e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123794889   292 GTHLWEFIRDILIHPElNEGLMKWENRHEGVFKFLRSEAVAQLWGQKKKNSNMTYEKLSRAMRYYYKREILERVDGRRLV 371
Cdd:smart00413   1 GIQLWQFLLDLLLDPE-NSDIIKWTDRDEGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLV 79


                   ....*...
gi 123794889   372 YKFGKNSS 379
Cdd:smart00413  80 YKFVKNPL 87
SAM_PNT-ESE-1-like cd08537
Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators; SAM ...
 74-151 6.09e-42

Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators; SAM Pointed domain of ESE-1-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. SAM Pointed domain of ESE-1 provides a potential docking site for signaling kinase Pak1 in humans. ESE-1 factors are involved in regulation of gene expression in different types of epithelial cells. ESE-1 is expressed in many different organs including intestine, stomach, pancreas, lungs, kidneys, and prostate. The DNA binding consensus motif for ESE-1 consists of a purine-rich GGA[AT] core sequence. The expression profile of these factors is altered in epithelial cancers if compared to normal tissues. Members of this subfamily are potential targets for cancer therapy.


Pssm-ID: 188880  Cd Length: 81  Bit Score: 141.90  E-value: 6.09e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 123794889  74 EKASWTSERPQFWSKTQVLEWISYQVEKNKYDASSIDFSRCDMDGATLCSCALEELRLVFGP-LGDQLHAQLRDLTSNS 151
Cdd:cd08537    3 TKGSWDQENPQFWSKQNVLEWISYHVEKNKYDASSLDLSYCTMDGLTLCACAKEQLMLVFGPeLGDLLHHSLEELTSRY 81
Ets pfam00178
Ets-domain;
294-374 2.57e-37

Ets-domain;


Pssm-ID: 459700  Cd Length: 80  Bit Score: 129.92  E-value: 2.57e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123794889  294 HLWEFIRDILIHPElNEGLMKWENRHEGVFKFLRSEAVAQLWGQKKKNSNMTYEKLSRAMRYYYKREILERVDGRRLVYK 373
Cdd:pfam00178   1 QLWQFLLDLLTDPE-YSDIIKWTDKEEGEFRLVDPEAVARLWGKRKGNPKMTYEKLSRALRYYYKKGILEKVPGKRLTYR 79


                  .
gi 123794889  374 F 374
Cdd:pfam00178  80 F 80
SAM_PNT pfam02198
Sterile alpha motif (SAM)/Pointed domain;
67-151 5.03e-26

Sterile alpha motif (SAM)/Pointed domain;


Pssm-ID: 460486  Cd Length: 83  Bit Score: 100.05  E-value: 5.03e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123794889   67 LAVLHLAEKASWTSERPQFWSKTQVLEWISYQVekNKYDASSIDFSRCDMDGATLCSCALEELRLVFGPLGDQLHAQLRD 146
Cdd:pfam02198   1 LPSFEKEQLRLWIPADPRLWTKDHVLEWLEWAV--DEFDLSKIDFSQFDMNGKALCSLGKEEFLQRAPGPGDILWSHLQI 78


                  ....*
gi 123794889  147 LTSNS 151
Cdd:pfam02198  79 LRKAS 83
SAM_PNT_ESE cd08757
Sterile alpha motif (SAM)/Pointed domain of ESE-like ETS transcriptional regulators; SAM ...
 83-149 8.68e-26

Sterile alpha motif (SAM)/Pointed domain of ESE-like ETS transcriptional regulators; SAM Pointed domain of ESE-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. It can act as a major transactivator by providing a potential docking site for co-activators. ETS factors are important for cell differentiation. They can be involved in regulation of gene expression in different types of epithelial cells. They are expressed in salivary gland, intestine, stomach, pancreas, lungs, kidneys, colon, mammary gland, and prostate. Members of this group are proto-oncogenes. Expression profiles of these factors are altered in epithelial cancers, which makes them potential targets for cancer therapy.


Pssm-ID: 188885  Cd Length: 69  Bit Score: 98.95  E-value: 8.68e-26
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 123794889  83 PQFWSKTQVLEWISYQVEKNKYDASSIDFSRCD-MDGATLCSCALEELRLVFGPLGDQLHAQLRDLTS 149
Cdd:cd08757    2 PQHWTKNDVLDWLLFVAEQNKIDAEEINFQKFDnIDGQTLCSMSLEEFIERDGVYGNLLYAELRRLLS 69
SAM_PNT smart00251
SAM / Pointed domain; A subfamily of the SAM domain
 72-150 7.89e-24

SAM / Pointed domain; A subfamily of the SAM domain


Pssm-ID: 128547  Cd Length: 82  Bit Score: 93.87  E-value: 7.89e-24
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 123794889    72 LAEKASWTSERPQFWSKTQVLEWISYQVekNKYDASSIDFSRCDMDGATLCSCALEELRLVFGPLGDQLHAQLRDLTSN 150
Cdd:smart00251   6 KEQKRLGIPADPQLWTEDHVLEWLEWAV--KEFSLSPIDFSKFDMSGKELCSMSKEEFLERAPFGGDILWSHLQILRKA 82
SAM_PNT cd08203
Sterile alpha motif (SAM)/Pointed domain; Sterile alpha motif (SAM)/Pointed domain is found in ...
 83-149 5.45e-17

Sterile alpha motif (SAM)/Pointed domain; Sterile alpha motif (SAM)/Pointed domain is found in about 40% of transcriptional regulators of ETS family (initially named for Erythroblastosis virus, E26-E Twenty Six). SAM Pointed domain containing proteins of this family additionally have a C-terminal ETS DNA-binding domain. In a few cases, SAM Pointed domain appears as a single domain protein. Members of this group are mostly involved in regulation of embryonic development and growth control in eukaryotes. SAM Pointed domains mediate protein-protein interactions. Depending on the subgroup, they can interact with other SAM Pointed domains forming homo or hetero dimers/oligomers and/or they can recruit a protein kinase to its target which can be a SAM Pointed domain containing protein itself or another protein that has no kinase docking site. Thus, SAM Pointed domains participate in transcriptional regulation and signal transduction. Some genes coding ETS family transcriptional regulators are proto-oncogenes. They are prone to chromosomal translocations resulting in gene fusions. Chimeric proteins with SAM Pointed domains were found in a number of different human tumors including myeloid leukemia, lymphoblastic leukemia, Ewing's sarcoma and primitive neuroectodermal tumor. Members of this family are potential targets for cancer therapy.


Pssm-ID: 188876  Cd Length: 67  Bit Score: 74.67  E-value: 5.45e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 123794889  83 PQFWSKTQVLEWISYQVEKNKYDAssIDFSRCDMDGATLCSCALEELRLVFGP-LGDQLHAQLRDLTS 149
Cdd:cd08203    2 PLEWTPEHVQQWLSWVSKKFSLDP--IDPDRFPMNGKELCALSKEDFRERAPSrGGDVLASHLALLRK 67
SAM_PNT-ESE-3-like cd08539
Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators; SAM ...
 78-150 2.77e-13

Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators; SAM Pointed domain of ESE-3-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. It can act as a major transactivator by providing a potential docking site for co-activators. The ESE-3 transcriptional activator is involved in regulation of glandular epithelium differentiation through the MAP kinase signaling cascade. It is found to be expressed in glandular epithelium of prostate, pancreas, salivary gland, and trachea. Additionally, ESE-3 is differentially expressed during monocyte-derived dendritic cells development. DNA binding consensus motif for ESE-3 consists of purine-rich GGAA/T core sequence. The expression profiles of these factors are altered in epithelial cancers. Members of this subfamily are potential targets for cancer therapy.


Pssm-ID: 188882  Cd Length: 78  Bit Score: 64.67  E-value: 2.77e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 123794889  78 WTSERPQFWSKTQVLEWISYQVEKNKYDASSIDFSRCDMDGATLCSCALEELRLVFGPLGDQLHAQLRDLTSN 150
Cdd:cd08539    4 WHEIHPQYWTKFQVWEWLQHLLDTNQLDANCIPFQEFDINGEHLCSMSLQEFTRAAGTAGQLLYSNLQHLKWN 76
SAM_PNT-ESE-2-like cd08538
Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators; SAM ...
 78-147 1.98e-09

Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators; SAM Pointed domain of ESE-2-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. It can act as a major transactivator by providing a potential docking site for co-activators. ESE-2 factors are involved in regulation of gene expression in a variety of epithelial (glandular and secretory) cells. ESE-2 mRNA was found in skin keratinocytes, salivary gland, mammary gland, stomach, prostate, and kidneys. The DNA binding consensus motif for ESE-2 consists of a GGA core and AT-rich flanks. The expression profiles of these factors are altered in epithelial cancers. Members of this subfamily are potential targets for cancer therapy.


Pssm-ID: 188881  Cd Length: 84  Bit Score: 53.87  E-value: 1.98e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123794889  78 WTSERPQFWSKTQVLEWISYQVEKNKYDASSIDFSRCDMDGATLCSCALEELRLVFGPLGDQLHAQLRDL 147
Cdd:cd08538    8 WTSVHPEYWTKRHVWEWLQFCCDQYKLDANCISFCHFNISGLQLCSMTQEEFLDAAGICGEYLYFILQNI 77
SAM_PNT-PDEF-like cd08532
Sterile alpha motif (SAM)/Pointed domain of prostate-derived ETS factor; SAM Pointed domain of ...
 83-144 1.28e-05

Sterile alpha motif (SAM)/Pointed domain of prostate-derived ETS factor; SAM Pointed domain of PDEF-like (Prostate-Derived ETS Factor) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. In human males this activator is highly expressed in the prostate gland and enhances androgen-mediated activation of the PSA promoter though interaction with the DNA binding domain of androgen receptor. PDEF may play a role in prostate cancer development as well as in goblet cell formation and mucus production in the epithelial lining of respiratory and intestinal tracts.


Pssm-ID: 188878  Cd Length: 81  Bit Score: 43.12  E-value: 1.28e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 123794889  83 PQFWSKTQVLEWIsyQVEKNKYDASSIDFSRCDMDGATLCSCALEELRLVFGPLGDQLHAQL 144
Cdd:cd08532   14 PYQWSTANVQAWL--QWTEHQYRLPPNPPRCFQMNGKTLCALSEEDFVRRAPQGGDTLHAQL 73
SAM_PNT-ETS-1 cd08542
Sterile alpha motif (SAM)/Pointed domain of ETS-1; SAM Pointed domain of ETS-1 subfamily of ...
 83-151 2.21e-05

Sterile alpha motif (SAM)/Pointed domain of ETS-1; SAM Pointed domain of ETS-1 subfamily of ETS transcriptional activators is a protein-protein interaction domain. The ETS-1 activator is regulated by phosphorylation. It contains a docking site for the ERK2 MAP (Mitogen Activated Protein) kinase, while the ERK2 phosphorylation site is located in the N-terminal disordered region upstream of the SAM Pointed domain. Mutations of the kinase docking site residues inhibit phosphorylation. ETS-1 activators play a role in a number of different physiological processes, and they are expressed during embryonic development, including blood vessel formation, hematopoietic, lymphoid, neuronal and osteogenic differentiation. The Ets-1 gene is a proto-oncogene involved in progression of different tumors (including breast cancer, meningioma, and prostate cancer). Members of this subfamily are potential molecular targets for selective cancer therapy.


Pssm-ID: 176092  Cd Length: 88  Bit Score: 42.66  E-value: 2.21e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 123794889  83 PQFWSKTQVLEWISYQVekNKYDASSIDFSRCDMDGATLCSCALE---ELRLVFgpLGDQLHAQLRDLTSNS 151
Cdd:cd08542   19 PREWTETHVREWVMWAV--NEFSLKGVDFQKFCMSGAALCALGKEcflELAPDF--VGDILWEHLEILQKED 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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