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Conserved domains on  [gi|1236518615|ref|YP_009414284|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Cheirogaleus crossleyi]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-173 1.83e-78

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 230.84  E-value: 1.83e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236518615   1 MVYAVFLLSVILVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236518615  81 TWGSNVVVWGALLMGFMMELLMILWVVGHDGVEVVVGLGSLESWMFFVEKGMSVVREDSLGVAALYSKTSWFMMIAGWSL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|...
gi 1236518615 161 FVSVLIVIEIIRG 173
Cdd:MTH00109  162 FIGVFVIIEITRG 174
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-173 1.83e-78

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 230.84  E-value: 1.83e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236518615   1 MVYAVFLLSVILVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236518615  81 TWGSNVVVWGALLMGFMMELLMILWVVGHDGVEVVVGLGSLESWMFFVEKGMSVVREDSLGVAALYSKTSWFMMIAGWSL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|...
gi 1236518615 161 FVSVLIVIEIIRG 173
Cdd:MTH00109  162 FIGVFVIIEITRG 174
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 9.28e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 51.35  E-value: 9.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236518615  21 SKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSNVVVWGALLMGFMMel 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLL-- 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236518615 101 lmilwvvghdGVEVVVGLGSLESWMFFVEKGMSVVREDSLGVaALYSKTSWFMMIAGWSLFVSVLIVIEI 170
Cdd:pfam00499  83 ----------LALLLLVLLSASLTPAAAAAAPDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-173 1.83e-78

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 230.84  E-value: 1.83e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236518615   1 MVYAVFLLSVILVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236518615  81 TWGSNVVVWGALLMGFMMELLMILWVVGHDGVEVVVGLGSLESWMFFVEKGMSVVREDSLGVAALYSKTSWFMMIAGWSL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|...
gi 1236518615 161 FVSVLIVIEIIRG 173
Cdd:MTH00109  162 FIGVFVIIEITRG 174
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-173 1.00e-35

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 122.17  E-value: 1.00e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236518615   1 MVYAVFLLSVILVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138    1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236518615  81 TWGSNVVVwgallmgfmmeLLMILWVVGHDGVEVVVGLGSLE-SWMFFVE-KGMSVVREDSLGVAALYSKTSWFMMIAGW 158
Cdd:MTH00138   81 SWGSWSVL-----------GYVVGYLVGVVLAAGLFWGGWYEgSWVVVDElKEFSVLRGDVGGVALMYSSGGGMLVICAW 149

                         170
                  ....*....|....*
gi 1236518615 159 SLFVSVLIVIEIIRG 173
Cdd:MTH00138  150 VLLLTLFVVLELTRG 164
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-173 7.70e-32

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 112.25  E-value: 7.70e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236518615   1 MVYAVFLLSVILVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065    1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236518615  81 TWGSNVVVWGALLMGFMMELLMILWvvghdgvevvVGLGSLESWMFFVEKGMSVVREDSLGVAALYSKTSWFMMIAGWSL 160
Cdd:MTH00065   81 AWGSWSVLVYVLFYLLLLIVGYILF----------GCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                         170
                  ....*....|...
gi 1236518615 161 FVSVLIVIEIIRG 173
Cdd:MTH00065  151 LLTLFVVLEVTRG 163
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-174 3.59e-27

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 100.21  E-value: 3.59e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236518615   1 MVYAVFLLSVILVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115    1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236518615  81 TWGSNVVVWGalLMGFMMELLMILWVVGHDGVEVVVGLGSLESWmffvekGMSVVREDSLGVAALYSKTSWFMMIAGWSL 160
Cdd:MTH00115   81 AWGDWGVVGY--VVGFVLVVVVVGVVVGGLWGMEGVGVVTVDSG------GLFVVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                         170
                  ....*....|....
gi 1236518615 161 FVSVLIVIEIIRGW 174
Cdd:MTH00115  153 LLTLFVVLELVRGL 166
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-173 4.42e-16

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 71.56  E-value: 4.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236518615   1 MVYAVFLLSVILVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214    1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236518615  81 TWGSnvvvwGALLMGFMMELLmilwvvghdGVEVVVGLGSLESWMFFVEKGMSVVREDSLGVAALYSKTSWFMMIAGWSL 160
Cdd:MTH00214   81 SWGG-----WSVLLFFLFYLL---------GLGFVGFYFYGGWEMLSWMGVDEANNLDLSGVSDLYSRGFFLLLLGGVVL 146

                         170
                  ....*....|...
gi 1236518615 161 FVSVLIVIEIIRG 173
Cdd:MTH00214  147 FLVLFVVLELVRG 159
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 1-173 3.58e-10

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 55.68  E-value: 3.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236518615   1 MVYAVFLLSVILVLGFMSFSSkpSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00045    1 MVFYLFLILMLFGSTLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236518615  81 TWGSNVVvwgallmgFMMELLMILWVvghdgvevvvgLGSLESWM-FFVEKGMSVVREDSLGVAALYSKTSWFMMIAGWS 159
Cdd:MTH00045   79 VSNLGEV--------LVLSLLLSLWV-----------FISFDNFLeLSNNNWSLVSLSDLVGSSELYNSGGLYLLLGGFI 139

                         170
                  ....*....|....
gi 1236518615 160 LFVSVLIVIEIIRG 173
Cdd:MTH00045  140 LLVALVVALVISFG 153
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 9.28e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 51.35  E-value: 9.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236518615  21 SKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSNVVVWGALLMGFMMel 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLL-- 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236518615 101 lmilwvvghdGVEVVVGLGSLESWMFFVEKGMSVVREDSLGVaALYSKTSWFMMIAGWSLFVSVLIVIEI 170
Cdd:pfam00499  83 ----------LALLLLVLLSASLTPAAAAAAPDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 7-78 4.22e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 38.83  E-value: 4.22e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1236518615   7 LLSVILVLGFMsFSSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEY 78
Cdd:MTH00212    6 LLSLLLLLMLL-FPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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