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Conserved domains on  [gi|1233977113|ref|WP_094622351|]
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MULTISPECIES: lytic transglycosylase domain-containing protein [unclassified Rhodococcus (in: high G+C Gram-positive bacteria)]

Protein Classification

lytic transglycosylase domain-containing protein( domain architecture ID 12989787)

lytic transglycosylase domain-containing protein similar to lytic transglycosylase which catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc)

PubMed:  9723170|7479697|8765311

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 91-233 1.73e-28

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


:

Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 103.93  E-value: 1.73e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233977113  91 CGIAWTTLAGIGYIESRHGTYQGSSvqpdglvappirgipldggpgvaeipdtdggsmdgdaeFDRAMGPMQFIPETWKK 170
Cdd:cd13399     1 YGVPPGILAAILGVESGFGPNAGGS--------------------------------------PAGAQGIAQFMPSTWKA 42

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1233977113 171 WGVDANGDGIADPDNIDDAALTAARYLCARGGDLR--TAQGWESALMAYNLS-GQYLRDVRDRAAA 233
Cdd:cd13399    43 YGVDGNGDGKADPFNPEDAIASAANYLCRHGWDLNafLGEDNFLALAAYNAGpGAYANAVLELAAT 108
 
Name Accession Description Interval E-value
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 91-233 1.73e-28

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 103.93  E-value: 1.73e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233977113  91 CGIAWTTLAGIGYIESRHGTYQGSSvqpdglvappirgipldggpgvaeipdtdggsmdgdaeFDRAMGPMQFIPETWKK 170
Cdd:cd13399     1 YGVPPGILAAILGVESGFGPNAGGS--------------------------------------PAGAQGIAQFMPSTWKA 42

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1233977113 171 WGVDANGDGIADPDNIDDAALTAARYLCARGGDLR--TAQGWESALMAYNLS-GQYLRDVRDRAAA 233
Cdd:cd13399    43 YGVDGNGDGKADPFNPEDAIASAANYLCRHGWDLNafLGEDNFLALAAYNAGpGAYANAVLELAAT 108
MltB COG2951
Membrane-bound lytic murein transglycosylase B [Cell wall/membrane/envelope biogenesis];
157-201 2.42e-09

Membrane-bound lytic murein transglycosylase B [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442193 [Multi-domain]  Cd Length: 326  Bit Score: 56.33  E-value: 2.42e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1233977113 157 AMGPMQFIPETWKKWGVDANGDGIADP-DNIDDAALTAARYLCARG 201
Cdd:COG2951   181 AMGQTQFMPSSYLRYAVDFDGDGRRDLwNSPPDALASTANYLKKHG 226
SLT_2 pfam13406
Transglycosylase SLT domain; This family is related to the SLT domain pfam01464.
 146-201 2.26e-08

Transglycosylase SLT domain; This family is related to the SLT domain pfam01464.


Pssm-ID: 404311 [Multi-domain]  Cd Length: 292  Bit Score: 53.32  E-value: 2.26e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1233977113 146 GSMDGdaefdrAMGPMQFIPETWKKWGVDANGDGIADP-DNIDDAALTAARYLCARG 201
Cdd:pfam13406 150 GSWAG------AMGQTQFMPSSYLAYAVDFDGDGRRDLwNSPPDALASVANYLKQHG 200
MltB_2 TIGR02283
lytic murein transglycosylase; Members of this family are closely related to the MltB family ...
 146-210 5.60e-07

lytic murein transglycosylase; Members of this family are closely related to the MltB family lytic murein transglycosylases described by TIGR02282 and are likewise all proteobacterial, although that family and this one form clearly distinct clades. Several species have one member of each family. Many members of this family (unlike the MltB family) contain an additional C-terminal domain, a putative peptidoglycan binding domain (pfam01471), not included in region described by this model. Many sequences appear to contain N-terminal lipoprotein attachment sites, as does E. coli MltB in TIGR02282. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274067 [Multi-domain]  Cd Length: 300  Bit Score: 49.30  E-value: 5.60e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1233977113 146 GSMDGdaefdrAMGPMQFIPETWKKWGVDANGDGIADP-DNIDDAALTAARYLCARGgdLRTAQGW 210
Cdd:TIGR02283 151 GSWAG------AMGQTQFLPSSYLNYAVDFDGDGRRDIwNSVPDALASTANYLVNGG--WKRGEPW 208
PRK10760 PRK10760
murein hydrolase B; Provisional
 154-201 1.30e-04

murein hydrolase B; Provisional


Pssm-ID: 236754 [Multi-domain]  Cd Length: 359  Bit Score: 42.42  E-value: 1.30e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1233977113 154 FDRAMGPMQFIPETWKKWGVDANGDGIADPDNIDDAALTAARYLCARG 201
Cdd:PRK10760  215 FAGAMGYGQFMPSSFKQYAVDFNGDGHINLWDPVDAIGSVANYFKAHG 262
 
Name Accession Description Interval E-value
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 91-233 1.73e-28

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 103.93  E-value: 1.73e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233977113  91 CGIAWTTLAGIGYIESRHGTYQGSSvqpdglvappirgipldggpgvaeipdtdggsmdgdaeFDRAMGPMQFIPETWKK 170
Cdd:cd13399     1 YGVPPGILAAILGVESGFGPNAGGS--------------------------------------PAGAQGIAQFMPSTWKA 42

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1233977113 171 WGVDANGDGIADPDNIDDAALTAARYLCARGGDLR--TAQGWESALMAYNLS-GQYLRDVRDRAAA 233
Cdd:cd13399    43 YGVDGNGDGKADPFNPEDAIASAANYLCRHGWDLNafLGEDNFLALAAYNAGpGAYANAVLELAAT 108
MltB COG2951
Membrane-bound lytic murein transglycosylase B [Cell wall/membrane/envelope biogenesis];
157-201 2.42e-09

Membrane-bound lytic murein transglycosylase B [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442193 [Multi-domain]  Cd Length: 326  Bit Score: 56.33  E-value: 2.42e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1233977113 157 AMGPMQFIPETWKKWGVDANGDGIADP-DNIDDAALTAARYLCARG 201
Cdd:COG2951   181 AMGQTQFMPSSYLRYAVDFDGDGRRDLwNSPPDALASTANYLKKHG 226
SLT_2 pfam13406
Transglycosylase SLT domain; This family is related to the SLT domain pfam01464.
 146-201 2.26e-08

Transglycosylase SLT domain; This family is related to the SLT domain pfam01464.


Pssm-ID: 404311 [Multi-domain]  Cd Length: 292  Bit Score: 53.32  E-value: 2.26e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1233977113 146 GSMDGdaefdrAMGPMQFIPETWKKWGVDANGDGIADP-DNIDDAALTAARYLCARG 201
Cdd:pfam13406 150 GSWAG------AMGQTQFMPSSYLAYAVDFDGDGRRDLwNSPPDALASVANYLKQHG 200
MltB_2 TIGR02283
lytic murein transglycosylase; Members of this family are closely related to the MltB family ...
 146-210 5.60e-07

lytic murein transglycosylase; Members of this family are closely related to the MltB family lytic murein transglycosylases described by TIGR02282 and are likewise all proteobacterial, although that family and this one form clearly distinct clades. Several species have one member of each family. Many members of this family (unlike the MltB family) contain an additional C-terminal domain, a putative peptidoglycan binding domain (pfam01471), not included in region described by this model. Many sequences appear to contain N-terminal lipoprotein attachment sites, as does E. coli MltB in TIGR02282. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274067 [Multi-domain]  Cd Length: 300  Bit Score: 49.30  E-value: 5.60e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1233977113 146 GSMDGdaefdrAMGPMQFIPETWKKWGVDANGDGIADP-DNIDDAALTAARYLCARGgdLRTAQGW 210
Cdd:TIGR02283 151 GSWAG------AMGQTQFLPSSYLNYAVDFDGDGRRDIwNSVPDALASTANYLVNGG--WKRGEPW 208
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 157-239 1.28e-05

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 42.97  E-value: 1.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233977113 157 AMGPMQFIPETWKKWGVDANGDgIADP-DNIDdaalTAARYLCARggdLRTAQG-WESALMAYNLSGQYLRDVRDRAAAY 234
Cdd:cd00254    24 ARGLMQLMPGTARDLGRRGVDD-LFDPeENIR----AGARYLREL---LDRFGGdLELALAAYNAGPGAVDRWGGGEVPP 95


                  ....*
gi 1233977113 235 SVGTR 239
Cdd:cd00254    96 YKETR 100
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 157-218 6.20e-05

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 43.06  E-value: 6.20e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1233977113 157 AMGPMQFIPETWKKWGVDAN-GDGIADPDNIDDAALTAARYLcargGDLRTAQG--WESALMAYN 218
Cdd:COG0741   141 ARGLMQLMPATARRLGLKLGlGPSPDDLFDPETNIRAGAAYL----RELLDRFDgdLVLALAAYN 201
PRK10760 PRK10760
murein hydrolase B; Provisional
 154-201 1.30e-04

murein hydrolase B; Provisional


Pssm-ID: 236754 [Multi-domain]  Cd Length: 359  Bit Score: 42.42  E-value: 1.30e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1233977113 154 FDRAMGPMQFIPETWKKWGVDANGDGIADPDNIDDAALTAARYLCARG 201
Cdd:PRK10760  215 FAGAMGYGQFMPSSFKQYAVDFNGDGHINLWDPVDAIGSVANYFKAHG 262
MltB TIGR02282
lytic murein transglycosylase B; This family consists of lytic murein transglycosylases ...
 141-201 2.94e-04

lytic murein transglycosylase B; This family consists of lytic murein transglycosylases (murein hydrolases) in the family of MltB, which is a membrane-bound lipoprotein in Escherichia coli. The N-terminal lipoprotein modification motif is conserved in about half the members of this family. The term Slt35 describes a naturally occurring soluble fragment of MltB. Members of this family never contain the putative peptidoglycan binding domain described by pfam01471, which is associated with several classes of bacterial cell wall lytic enzymes. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274066 [Multi-domain]  Cd Length: 290  Bit Score: 41.22  E-value: 2.94e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1233977113 141 PDTDGGSMDGdaefdrAMGPMQFIPETWKKWGVDANGDGIAD-PDNIDDAALTAARYLCARG 201
Cdd:TIGR02282 141 PLTLKGSYAG------AMGYPQFMPSSYRQYAVDFDGDGHIDlWNSPDDAIGSVANYFHAHG 196
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 156-218 5.73e-03

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 35.96  E-value: 5.73e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1233977113 156 RAMGPMQFIPETWKKWG--VDANGDGIADPdniDDAALTAARYLcargGDLRTAQG-WESALMAYN 218
Cdd:cd16894    29 GAAGLWQFMPATAREYGlrVDSWVDERRDP---EKSTRAAARYL----KDLYKRFGdWLLALAAYN 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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