NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1233028414|gb|AST54074|]
View 

DNA-binding response regulator [Parabacteroides sp. CT06]

Protein Classification

LytR/AlgR family response regulator transcription factor( domain architecture ID 11461715)

LytR/AlgR family response regulator transcription factor with a signal receiver (REC) and a DNA-binding domain may be part of a two-component regulatory system

CATH:  3.40.50.2300|2.40.50.1020
Gene Ontology:  GO:0000160|GO:0000156|GO:0003677
PubMed:  11557134|27013338|18462668|31100988|20226724|16740923|12034833
SCOP:  4003632|4004734

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 3-226 5.96e-75

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


:

Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 226.62  E-value: 5.96e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   3 TLTCMIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMVP---PSTRVIF 79
Cdd:COG3279     1 MMKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLReldPPPPIIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414  80 TTAFKEYAFDSYEVNALDFLLKPIRYHKFLGAAEKARQWFEMNSV----KEERGSLFVRVDSQLRQVEISRILYVTGLKD 155
Cdd:COG3279    81 TTAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAaeasPEEKDRIFVKSGGKLVKIPLDDILYIEAEGN 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1233028414 156 YVMIYLEGeaRPLITHVTMKAMEEMLSTGRFMRVHRSYIVALDKIRSVDRNNCVYI---GKEIIHVTDAYKEAF 226
Cdd:COG3279   161 YVKIHTKD--KKYLVRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEKNFNGEVvlkNGEEIPVSRRYKKEF 232
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 3-226 5.96e-75

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 226.62  E-value: 5.96e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   3 TLTCMIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMVP---PSTRVIF 79
Cdd:COG3279     1 MMKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLReldPPPPIIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414  80 TTAFKEYAFDSYEVNALDFLLKPIRYHKFLGAAEKARQWFEMNSV----KEERGSLFVRVDSQLRQVEISRILYVTGLKD 155
Cdd:COG3279    81 TTAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAaeasPEEKDRIFVKSGGKLVKIPLDDILYIEAEGN 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1233028414 156 YVMIYLEGeaRPLITHVTMKAMEEMLSTGRFMRVHRSYIVALDKIRSVDRNNCVYI---GKEIIHVTDAYKEAF 226
Cdd:COG3279   161 YVKIHTKD--KKYLVRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEKNFNGEVvlkNGEEIPVSRRYKKEF 232
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 6-117 2.42e-34

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 119.18  E-value: 2.42e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   6 CMIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV-----PPstRVIFT 80
Cdd:cd17532     1 ALIVDDEPLAREELRYLLEEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLsklakPP--LIVFV 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1233028414  81 TAFKEYAFDSYEVNALDFLLKPIRYHKFLGAAEKARQ 117
Cdd:cd17532    79 TAYDEYAVEAFELNAVDYLLKPFSEERLAEALAKLRK 115
PRK11697 PRK11697
two-component system response regulator BtsR;
4-201 4.56e-27

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 103.77  E-value: 4.56e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   4 LTCMIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTL-RESPvDVLFLDIQMPDLDGLNLSRMVPPST--RVIFT 80
Cdd:PRK11697    2 IKVLIVDDEPLAREELRELLQEEGDIEIVGECSNAIEAIGAIhRLKP-DVVFLDIQMPRISGLELVGMLDPEHmpYIVFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414  81 TAFKEYAFDSYEVNALDFLLKPI---RYHKFLgaaEKARQWFEMNSVkeergsLFVRVDSQLRQ-----------VEISR 146
Cdd:PRK11697   81 TAFDEYAIKAFEEHAFDYLLKPIdpaRLAKTL---ARLRQERSPQDV------LLPEAQPPLKHipctghnriklLPLEE 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1233028414 147 ILYVTglKDYVMIYLEGEARPLITHVTMKAMEEMLStgrFMRVHRSYIVALDKIR 201
Cdd:PRK11697  152 VEFVS--SRLSGVHVVSAEGKGFTELTLKTLEEKTP---LLRCHRQYLVNPAAIQ 201
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 7-103 4.09e-17

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 74.11  E-value: 4.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLrlAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV---PPSTRVIFTTAF 83
Cdd:pfam00072   2 LIVDDDPLIRELLRQLLEKEGYV--VAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIrrrDPTTPVIILTAH 79

                          90       100
                  ....*....|....*....|..
gi 1233028414  84 --KEYAFDSYEVNALDFLLKPI 103
Cdd:pfam00072  80 gdEDDAVEALEAGADDFLSKPF 101
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 137-229 9.10e-17

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 72.99  E-value: 9.10e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414  137 SQLRQVEISRILYVTGLKDYVMIYLEGEArpLITHVTMKAMEEMLSTGRFMRVHRSYIVALDKIRSVDRNNC-----VYI 211
Cdd:smart00850   1 GRIVLIPLDDILYIEAEGNYVTVHTKDGT--YLVRGTLKELEERLDPDNFFRIHRSYIVNLDHIKEIEPWFNgtyllILK 78

                           90
                   ....*....|....*...
gi 1233028414  212 GKEIIHVTDAYKEAFNAY 229
Cdd:smart00850  79 NGEEVPVSRRYLKELKER 96
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 8-103 3.80e-06

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 46.71  E-value: 3.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   8 IVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLN-LSRMVPPST----RVIFTTA 82
Cdd:TIGR02875   7 IADDNKEFCNLLKEYLAAQPDMEVVGVAHNGVDALELIKEQQPDVVVLDIIMPHLDGIGvLEKLNEIELsarpRVIMLSA 86

                          90       100
                  ....*....|....*....|...
gi 1233028414  83 FKEYAFDSYEVN--ALDFLLKPI 103
Cdd:TIGR02875  87 FGQEKITQRAVAlgADYYVLKPF 109
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 3-226 5.96e-75

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 226.62  E-value: 5.96e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   3 TLTCMIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMVP---PSTRVIF 79
Cdd:COG3279     1 MMKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLReldPPPPIIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414  80 TTAFKEYAFDSYEVNALDFLLKPIRYHKFLGAAEKARQWFEMNSV----KEERGSLFVRVDSQLRQVEISRILYVTGLKD 155
Cdd:COG3279    81 TTAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAaeasPEEKDRIFVKSGGKLVKIPLDDILYIEAEGN 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1233028414 156 YVMIYLEGeaRPLITHVTMKAMEEMLSTGRFMRVHRSYIVALDKIRSVDRNNCVYI---GKEIIHVTDAYKEAF 226
Cdd:COG3279   161 YVKIHTKD--KKYLVRKTLKELEEKLPPKQFFRVHRSYIVNLDKIKEIEKNFNGEVvlkNGEEIPVSRRYKKEF 232
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 6-117 2.42e-34

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 119.18  E-value: 2.42e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   6 CMIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV-----PPstRVIFT 80
Cdd:cd17532     1 ALIVDDEPLAREELRYLLEEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLsklakPP--LIVFV 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1233028414  81 TAFKEYAFDSYEVNALDFLLKPIRYHKFLGAAEKARQ 117
Cdd:cd17532    79 TAYDEYAVEAFELNAVDYLLKPFSEERLAEALAKLRK 115
PRK11697 PRK11697
two-component system response regulator BtsR;
4-201 4.56e-27

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 103.77  E-value: 4.56e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   4 LTCMIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTL-RESPvDVLFLDIQMPDLDGLNLSRMVPPST--RVIFT 80
Cdd:PRK11697    2 IKVLIVDDEPLAREELRELLQEEGDIEIVGECSNAIEAIGAIhRLKP-DVVFLDIQMPRISGLELVGMLDPEHmpYIVFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414  81 TAFKEYAFDSYEVNALDFLLKPI---RYHKFLgaaEKARQWFEMNSVkeergsLFVRVDSQLRQ-----------VEISR 146
Cdd:PRK11697   81 TAFDEYAIKAFEEHAFDYLLKPIdpaRLAKTL---ARLRQERSPQDV------LLPEAQPPLKHipctghnriklLPLEE 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1233028414 147 ILYVTglKDYVMIYLEGEARPLITHVTMKAMEEMLStgrFMRVHRSYIVALDKIR 201
Cdd:PRK11697  152 VEFVS--SRLSGVHVVSAEGKGFTELTLKTLEEKTP---LLRCHRQYLVNPAAIQ 201
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 7-117 9.94e-21

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 83.93  E-value: 9.94e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPY-LRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV---PPSTRVIFTTA 82
Cdd:cd17536     2 LIVDDEPLIREGLKKLIDWEELgFEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIrelYPDIKIIILSG 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1233028414  83 FK--EYAFDSYEVNALDFLLKPIRYHKFLGAAEKARQ 117
Cdd:cd17536    82 YDdfEYAQKAIRLGVVDYLLKPVDEEELEEALEKAKE 118
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 5-102 1.48e-19

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 80.20  E-value: 1.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   5 TCMIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV---PPSTRVIFTT 81
Cdd:COG4753     1 KVLIVDDEPLIREGLKRILEWEAGFEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIrelDPDTKIIILS 80

                          90       100
                  ....*....|....*....|...
gi 1233028414  82 AF--KEYAFDSYEVNALDFLLKP 102
Cdd:COG4753    81 GYsdFEYAQEAIKLGADDYLLKP 103
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-117 3.02e-19

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 80.78  E-value: 3.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   1 MKTLTCMIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV---PPSTRV 77
Cdd:COG4565     1 MKMIRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELrarGPDVDV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1233028414  78 IFTTAFKEYAF--DSYEVNALDFLLKPIRYHKFLGAAEKARQ 117
Cdd:COG4565    81 IVITAARDPETvrEALRAGVVDYLIKPFTFERLREALERYLE 122
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 7-102 3.15e-17

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 74.19  E-value: 3.15e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLrlAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV---PPSTRVIFTTAF 83
Cdd:cd00156     1 LIVDDDPAIRELLKSLLEREGYE--VDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLrelPPDIPVIVLTAK 78

                          90       100
                  ....*....|....*....|.
gi 1233028414  84 --KEYAFDSYEVNALDFLLKP 102
Cdd:cd00156    79 adEEDAVRALELGADDYLVKP 99
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 7-103 4.09e-17

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 74.11  E-value: 4.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLrlAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV---PPSTRVIFTTAF 83
Cdd:pfam00072   2 LIVDDDPLIRELLRQLLEKEGYV--VAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIrrrDPTTPVIILTAH 79

                          90       100
                  ....*....|....*....|..
gi 1233028414  84 --KEYAFDSYEVNALDFLLKPI 103
Cdd:pfam00072  80 gdEDDAVEALEAGADDFLSKPF 101
PRK14084 PRK14084
DNA-binding response regulator;
1-204 6.94e-17

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 77.10  E-value: 6.94e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   1 MKTLtcmIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV-----PPst 75
Cdd:PRK14084    1 MKAL---IVDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDINLMDESGIELAAKIqkmkePP-- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414  76 RVIFTTAFKEYAFDSYEVNALDFLLKPIRYHKFLGAAEKARQwfEMNSVKEERGSLFVRVDSQLRQV---EISRILYVTG 152
Cdd:PRK14084   76 AIIFATAHDQFAVKAFELNATDYILKPFEQKRIEQAVNKVRA--TKAKDDNNASAIANDMSANFDQSlpiEIDDKIHMLN 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1233028414 153 LKDYVMIYLEGEARPLIT-------HVTMKAMEEMLSTGRFMRVHRSYIVALDKIRSVD 204
Cdd:PRK14084  154 QQDIIAIGVHNGITTIHTtnhkyetTEPLNRYEKRLNPTYFIRIHRSYIINKKHIKEVE 212
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 137-229 9.10e-17

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 72.99  E-value: 9.10e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414  137 SQLRQVEISRILYVTGLKDYVMIYLEGEArpLITHVTMKAMEEMLSTGRFMRVHRSYIVALDKIRSVDRNNC-----VYI 211
Cdd:smart00850   1 GRIVLIPLDDILYIEAEGNYVTVHTKDGT--YLVRGTLKELEERLDPDNFFRIHRSYIVNLDHIKEIEPWFNgtyllILK 78

                           90
                   ....*....|....*...
gi 1233028414  212 GKEIIHVTDAYKEAFNAY 229
Cdd:smart00850  79 NGEEVPVSRRYLKELKER 96
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-115 2.22e-16

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 72.58  E-value: 2.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   1 MKTLTCMIVDDEPLAVKMLEDFVSRTPYLRLAASfnDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV-----PPST 75
Cdd:COG0784     3 LGGKRILVVDDNPDNRELLRRLLERLGYEVTTAE--DGAEALELLRAGPPDLILLDINMPGMDGLELLRRIralprLPDI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1233028414  76 RVIFTTA--FKEYAFDSYEVNALDFLLKPIRYHKFLGAAEKA 115
Cdd:COG0784    81 PIIALTAyaDEEDRERALEAGADDYLTKPVDPEELLEALRRL 122
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 7-115 8.13e-15

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 72.69  E-value: 8.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPY-LRLAASFNDpvlALSTLRESPVDVLFLDIQMPDLDGLNLSRMV---PPSTRVIFTTA 82
Cdd:COG2204     6 LVVDDDPDIRRLLKELLERAGYeVETAASGEE---ALALLREEPPDLVLLDLRMPGMDGLELLRELralDPDLPVILLTG 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1233028414  83 F--KEYAFDSYEVNALDFLLKPIRYHKFLGAAEKA 115
Cdd:COG2204    83 YgdVETAVEAIKAGAFDYLTKPFDLEELLAAVERA 117
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 137-231 3.01e-14

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 66.08  E-value: 3.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414 137 SQLRQVEISRILYVTGLKDYVMIYLEGEARplITHVTMKAMEEMLSTGRFMRVHRSYIVALDKIRSVDRN-NCVYI---- 211
Cdd:pfam04397   1 DRIILVPIDDILYIEAEDKYVTIHTANGEY--LTRGTLKELEEKLPPDGFFRCHRSYLVNLNKIKEIDPDfNGTYEltlk 78

                          90       100
                  ....*....|....*....|
gi 1233028414 212 GKEIIHVTDAYKEAFNAYLK 231
Cdd:pfam04397  79 NGEKIPVSRRYLKELKELLG 98
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 7-109 1.11e-13

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 65.16  E-value: 1.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLRLAaSFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNL---------SRMVPpstrV 77
Cdd:cd17551     4 LIVDDNPTNLLLLEALLRSAGYLEVV-SFTDPREALAWCRENPPDLILLDYMMPGMDGLEFirrlralpgLEDVP----I 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1233028414  78 IFTTA-----FKEYAFdsyEVNALDFLLKPIRYHKFL 109
Cdd:cd17551    79 VMITAdtdreVRLRAL---EAGATDFLTKPFDPVELL 112
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 3-104 2.39e-13

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 66.09  E-value: 2.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   3 TLTCMIVDDEPLAVKMLEDFVSRTPYLRLAASfnDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV--PPSTR---V 77
Cdd:COG3706     1 PARILVVDDDPTNRKLLRRLLEAAGYEVVEAA--DGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLraDPRTAdipI 78

                          90       100
                  ....*....|....*....|....*....
gi 1233028414  78 IFTTAF--KEYAFDSYEVNALDFLLKPIR 104
Cdd:COG3706    79 IFLTALddEEDRARALEAGADDYLTKPFD 107
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 7-103 3.90e-13

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 66.34  E-value: 3.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLRLAAsfNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV-----PPSTRVIFTT 81
Cdd:COG3437    10 LIVDDDPENLELLRQLLRTLGYDVVTA--ESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLradpsTRDIPVIFLT 87

                          90       100
                  ....*....|....*....|....
gi 1233028414  82 AF--KEYAFDSYEVNALDFLLKPI 103
Cdd:COG3437    88 ALadPEDRERALEAGADDYLTKPF 111
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 4-108 2.72e-12

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 61.49  E-value: 2.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   4 LTCMIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMVP---PSTRVIFT 80
Cdd:cd19925     1 INVLIVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRaagHDVDVIVV 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1233028414  81 TAFKEYAF--DSYEVNALDFLLKPIRYHKF 108
Cdd:cd19925    81 TAANDVETvrEALRLGVVDYLIKPFTFERL 110
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 7-103 9.29e-12

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 59.83  E-value: 9.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLRLAASfnDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMVP--PSTR---VIFTT 81
Cdd:cd19920     2 LIVDDVPDNLRLLSELLRAAGYRVLVAT--DGQQALQRAQAEPPDLILLDVMMPGMDGFEVCRRLKadPATRhipVIFLT 79

                          90       100
                  ....*....|....*....|....*..
gi 1233028414  82 AF-----KEYAFdsyEVNALDFLLKPI 103
Cdd:cd19920    80 ALtdtedKVKGF---ELGAVDYITKPF 103
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 7-102 5.06e-11

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 58.17  E-value: 5.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV----PpsTRVI---- 78
Cdd:cd17541     4 LIVDDSAVMRKLLSRILESDPDIEVVGTARDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRImaerP--TPVVmvss 81

                          90       100
                  ....*....|....*....|....
gi 1233028414  79 FTTAFKEYAFDSYEVNALDFLLKP 102
Cdd:cd17541    82 LTEEGAEITLEALELGAVDFIAKP 105
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 7-104 3.39e-10

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 57.66  E-value: 3.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPY-LRLAASFNDpvlALSTLRESPVDVLFLDIQMPDLDGLNLSRMV---PPSTRVIFTTA 82
Cdd:COG0745     5 LVVEDDPDIRELLADALEREGYeVDTAADGEE---ALELLEEERPDLILLDLMLPGMDGLEVCRRLrarPSDIPIIMLTA 81

                          90       100
                  ....*....|....*....|....
gi 1233028414  83 F--KEYAFDSYEVNALDFLLKPIR 104
Cdd:COG0745    82 RddEEDRVRGLEAGADDYLTKPFD 105
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 7-101 3.55e-10

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 55.60  E-value: 3.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV---PPSTRVIFTTAF 83
Cdd:cd17535     2 LIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLrrrYPDLKVIVLTAH 81

                          90       100
                  ....*....|....*....|
gi 1233028414  84 KE--YAFDSYEVNALDFLLK 101
Cdd:cd17535    82 DDpeYVLRALKAGAAGYLLK 101
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 50-108 1.12e-09

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 54.94  E-value: 1.12e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1233028414  50 VDVLFLDIQMPDLDGLNLS---RMVPPSTRVIFTTAFKEYAFDSYE--VNALDFLLKPIRYHKF 108
Cdd:cd17533    54 IYFLDIDIKMEEKNGLEVAqkiRKYDPYAIIIFVTTHSEFAPLTFEykVAALDFILKPLKLEEF 117
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 8-103 1.49e-09

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 53.66  E-value: 1.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   8 IVDDEPLAVKMLEDFVSRTPYLRLAAsfNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMVP--PSTR---VIFTTA 82
Cdd:cd17538     4 VVDDEPANRELLEALLSAEGYEVLTA--DSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKedPETRhipVIMITA 81

                          90       100
                  ....*....|....*....|...
gi 1233028414  83 F--KEYAFDSYEVNALDFLLKPI 103
Cdd:cd17538    82 LddREDRIRGLEAGADDFLSKPI 104
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 7-114 1.89e-09

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 53.70  E-value: 1.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLRLAASfnDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMVP--PSTRVIFTTAFK 84
Cdd:cd17548     3 LIVEDNPLNMKLARDLLESAGYEVLEAA--DGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLKedPATRDIPVIALT 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1233028414  85 EYAFDSYEVNAL-----DFLLKPIRYHKFLGAAEK 114
Cdd:cd17548    81 AYAMKGDREKILeagcdGYISKPIDTREFLETVAK 115
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
1-131 2.31e-09

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 56.78  E-value: 2.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   1 MKTL-TCMIVDDEPLAVKMLEDFVSRTPYLRLAASfnDPVLALSTLRESPVDVLFLDIQMPDLDG---LNLSRMVPPSTR 76
Cdd:PRK11361    1 MTAInRILIVDDEDNVRRMLSTAFALQGFETHCAN--NGRTALHLFADIHPDVVLMDIRMPEMDGikaLKEMRSHETRTP 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1233028414  77 VIFTTAFKEY--AFDSYEVNALDFLLKPIRYHKFLGAAEKARQwfeMNSVKEERGSL 131
Cdd:PRK11361   79 VILMTAYAEVetAVEALRCGAFDYVIKPFDLDELNLIVQRALQ---LQSMKKEIRHL 132
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-131 2.60e-09

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 54.96  E-value: 2.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   1 MKTLTCMIVDDEPLAVKMLEDFVSRTPYLRLAASfNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMVPPSTR--VI 78
Cdd:COG3707     1 MRGLRVLVVDDEPLRRADLREGLREAGYEVVAEA-ADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPapVI 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1233028414  79 FTTAFKEYAF--DSYEVNALDFLLKPIRYHKFLGAAEKAR-QWFEMNSVKEERGSL 131
Cdd:COG3707    80 LLTAYSDPELieRALEAGVSAYLVKPLDPEDLLPALELALaRFRELRALRRELAKL 135
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 7-102 7.68e-09

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 51.64  E-value: 7.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPY-LRLAASFNDpvlALSTLRESPVDVLFLDIQMPDLDGLNLSRMV---PPSTRVIFTTA 82
Cdd:cd17574     1 LVVEDDEEIAELLSDYLEKEGYeVDTAADGEE---ALELAREEQPDLIILDVMLPGMDGFEVCRRLrekGSDIPIIMLTA 77

                          90       100
                  ....*....|....*....|....*
gi 1233028414  83 FKEyafDSYEVNAL-----DFLLKP 102
Cdd:cd17574    78 KDE---EEDKVLGLelgadDYITKP 99
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 7-105 1.30e-08

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 51.32  E-value: 1.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEP----LAVKMLEDFVSRtpylrlAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV------PPSTR 76
Cdd:cd17546     2 LVVDDNPvnrkVLKKLLEKLGYE------VDVAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIreleggGRRTP 75

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1233028414  77 VIFTTAfkeYAFDSYEVNAL-----DFLLKPIRY 105
Cdd:cd17546    76 IIALTA---NALEEDREKCLeagmdDYLSKPVKL 106
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-102 2.25e-08

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 53.62  E-value: 2.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   1 MKTLTCMIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGL----NLSRMVPpsTR 76
Cdd:PRK00742    1 MMKIRVLVVDDSAFMRRLISEILNSDPDIEVVGTAPDGLEAREKIKKLNPDVITLDVEMPVMDGLdaleKIMRLRP--TP 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 1233028414  77 VI----FTTAFKEYAFDSYEVNALDFLLKP 102
Cdd:PRK00742   79 VVmvssLTERGAEITLRALELGAVDFVTKP 108
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 7-69 2.34e-08

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 51.05  E-value: 2.34e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSR 69
Cdd:COG2197     5 LIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALR 67
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 7-115 3.78e-08

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 50.35  E-value: 3.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYlRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV---PPSTRVIFTTAF 83
Cdd:cd17542     4 LIVDDAAFMRMMLKDILTKAGY-EVVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIkkiDPNAKVIMCSAM 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1233028414  84 KEYAF--DSYEVNALDFLLKPIRYHKFLGAAEKA 115
Cdd:cd17542    83 GQEEMvkEAIKAGAKDFIVKPFQPERVLEAVEKV 116
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 8-115 3.87e-08

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 50.19  E-value: 3.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   8 IVDDEPLAVKMLEDFVSRTPYL-RLAASFNDpvlALSTLRESPVDVLFLDIQMPDLDGLNLSRMVP---PSTRVIFTT-- 81
Cdd:cd17550     3 IVDDEEDIRESLSGILEDEGYEvDTAADGEE---ALKLIKERRPDLVLLDIWLPDMDGLELLKEIKekyPDLPVIMISgh 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1233028414  82 AFKEYAFDSYEVNALDFLLKPIRYHKFLGAAEKA 115
Cdd:cd17550    80 GTIETAVKATKLGAYDFIEKPLSLDRLLLTIERA 113
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 9-71 1.65e-07

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 48.13  E-value: 1.65e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1233028414   9 VDDEPLAVKMLEDFVSRTPYLrlAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV 71
Cdd:cd17602     4 VDDRPSIQKMIEYFLEKQGFR--VVVIDDPLRALTTLLNSKPDLILIDIDMPDLDGYELCSLL 64
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 7-102 2.09e-07

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 47.99  E-value: 2.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLN-LSRMV----PPSTRVIFTT 81
Cdd:cd17561     5 LIADDNREFVQLLEEYLNSQPDMEVVGVAHNGQEALELIEEKEPDVLLLDIIMPHLDGIGvLEKLRrmrlEKRPKIIMLT 84

                          90       100
                  ....*....|....*....|...
gi 1233028414  82 AFKEYAFDSYEVN--ALDFLLKP 102
Cdd:cd17561    85 AFGQEDITQRAVElgASYYILKP 107
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
8-102 2.29e-07

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 50.65  E-value: 2.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   8 IVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV---PPSTRVIFTTAFK 84
Cdd:PRK12555    5 IVNDSPLAVEALRRALARDPDHEVVWVATDGAQAVERCAAQPPDVILMDLEMPRMDGVEATRRImaeRPCPILIVTSLTE 84

                          90       100
                  ....*....|....*....|.
gi 1233028414  85 EYAFDSYEV---NALDFLLKP 102
Cdd:PRK12555   85 RNASRVFEAmgaGALDAVDTP 105
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 7-103 3.25e-07

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 47.58  E-value: 3.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVkMLEDFVSRTPY-LRLAASFNDpvlALSTLRESPVDVLFLDIQMPDLDGLNLSRMV---PPSTRVIFTTA 82
Cdd:cd17572     3 LVEDSPSLAA-LYQEYLSDEGYkVTHVETGKE---ALAFLSDQPPDVVLLDLKLPDMSGMEILKWIqerSLPTSVIVITA 78

                          90       100
                  ....*....|....*....|...
gi 1233028414  83 F--KEYAFDSYEVNALDFLLKPI 103
Cdd:cd17572    79 HgsVDIAVEAMRLGAYDFLEKPF 101
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 32-115 3.44e-07

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 47.65  E-value: 3.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414  32 AASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMVP---PSTRVIFTTAFK--EYAFDSYEVNALDFLLKPIRYH 106
Cdd:cd19919    27 VTSFENAQEALAALASSQPDVLISDIRMPGMDGLALLAQIKqrhPDLPVIIMTAHSdlDSAVSAYQGGAFEYLPKPFDID 106


                  ....*....
gi 1233028414 107 KFLGAAEKA 115
Cdd:cd19919   107 EAVALVERA 115
Spo0A COG5801
Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell ...
 1-83 3.63e-07

Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444503 [Multi-domain]  Cd Length: 264  Bit Score: 49.80  E-value: 3.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   1 MKTLTCMIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGL----NLSRM-VPPST 75
Cdd:COG5801     2 MEKIKVLIADDNREFCELLEEYLSSQPDMEVVGVAYNGLEALELIEEKKPDVVILDIIMPHLDGLgvleKLREMnLEKRP 81


                  ....*...
gi 1233028414  76 RVIFTTAF 83
Cdd:COG5801    82 KVIMLTAF 89
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 8-115 4.11e-07

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 49.87  E-value: 4.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   8 IVDDEPLAVKMLEDFVSRTPYLrlAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMVP---PSTRVIFTTAFK 84
Cdd:PRK10923    8 VVDDDSSIRWVLERALAGAGLT--CTTFENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKqrhPMLPVIIMTAHS 85

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1233028414  85 EY--AFDSYEVNALDFLLKPIRYHKFLGAAEKA 115
Cdd:PRK10923   86 DLdaAVSAYQQGAFDYLPKPFDIDEAVALVERA 118
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 7-83 8.59e-07

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 46.30  E-value: 8.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLRLAASfnDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV---PP--STRVIFTT 81
Cdd:cd17580     2 LVVDDNEDAAEMLALLLELEGAEVTTAH--SGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLrelPWlaNTPAIALT 79


                  ..
gi 1233028414  82 AF 83
Cdd:cd17580    80 GY 81
pleD PRK09581
response regulator PleD; Reviewed
 3-103 2.48e-06

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 47.59  E-value: 2.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   3 TLTCMIVDDEPLAVKMLEDFVSRTPYLRLAASfnDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMVP--PSTR---V 77
Cdd:PRK09581    2 TARILVVDDIPANVKLLEAKLLAEYYTVLTAS--SGAEAIAICEREQPDIILLDVMMPGMDGFEVCRRLKsdPATThipV 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1233028414  78 IFTTafkeyAFDSYE--VNAL-----DFLLKPI 103
Cdd:PRK09581   80 VMVT-----ALDDPEdrVRGLeagadDFLTKPI 107
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 7-86 3.60e-06

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 44.52  E-value: 3.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLRLAASfnDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV---PPSTRVIFTTAF 83
Cdd:cd17554     4 LVVDDEENIRELYKEELEDEGYEVVTAG--NGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIrekKPDLPVIICTAY 81


                  ...
gi 1233028414  84 KEY 86
Cdd:cd17554    82 SEY 84
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 8-103 3.80e-06

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 46.71  E-value: 3.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   8 IVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLN-LSRMVPPST----RVIFTTA 82
Cdd:TIGR02875   7 IADDNKEFCNLLKEYLAAQPDMEVVGVAHNGVDALELIKEQQPDVVVLDIIMPHLDGIGvLEKLNEIELsarpRVIMLSA 86

                          90       100
                  ....*....|....*....|...
gi 1233028414  83 FKEYAFDSYEVN--ALDFLLKPI 103
Cdd:TIGR02875  87 FGQEKITQRAVAlgADYYVLKPF 109
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
7-115 3.91e-06

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 46.95  E-value: 3.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPY-LRLAASFNDpvlALSTLRESPVDVLFLDIQMPDLDGLNLSRMVP---PSTRVIFTTA 82
Cdd:PRK10365    9 LVVDDDISHCTILQALLRGWGYnVALANSGRQ---ALEQVREQVFDLVLCDVRMAEMDGIATLKEIKalnPAIPVLIMTA 85

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1233028414  83 FK--EYAFDSYEVNALDFLLKPIRYHKFLGAAEKA 115
Cdd:PRK10365   86 YSsvETAVEALKTGALDYLIKPLDFDNLQATLEKA 120
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 8-84 4.07e-06

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 44.57  E-value: 4.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   8 IVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLS---RMVPPSTRVIFTTAFK 84
Cdd:cd19930     3 IAEDQEMVRGALAALLELEDDLEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAaelREELPDTKVLIVTTFG 82
PRK13557 PRK13557
histidine kinase; Provisional
 5-117 4.22e-06

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 46.97  E-value: 4.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   5 TCMIVDDEP----LAVKMLEDFVSRTpylRLAASfndPVLALSTLRESP-VDVLFLDIQMP-DLDGLNLSRMVP---PST 75
Cdd:PRK13557  417 TILIVDDRPdvaeLARMILEDFGYRT---LVASN---GREALEILDSHPeVDLLFTDLIMPgGMNGVMLAREARrrqPKI 490

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1233028414  76 RVIFTTAFKEYAFDSYEVNALDF--LLKPIRYHKFlgaAEKARQ 117
Cdd:PRK13557  491 KVLLTTGYAEASIERTDAGGSEFdiLNKPYRRAEL---ARRVRM 531
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 7-102 5.97e-06

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 43.87  E-value: 5.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLRLAASfnDPVLALSTLRESP-VDVLFLDIQMPD-LDGLNL---SRMVPPSTRVIFTT 81
Cdd:cd18161     2 LVVEDDPDVRRLTAEVLEDLGYTVLEAA--SGDEALDLLESGPdIDLLVTDVIMPGgMNGSQLaeeARRRRPDLKVLLTS 79

                          90       100
                  ....*....|....*....|..
gi 1233028414  82 AFKEYAFDSYE-VNALDFLLKP 102
Cdd:cd18161    80 GYAENAIEGGDlAPGVDVLSKP 101
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 7-103 6.21e-06

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 44.19  E-value: 6.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLRLAASfnDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV-----PPSTRVIFTT 81
Cdd:cd19937     1 LVVDDEEDIVELLKYNLEKEGYEVVTAY--DGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILrsdpkTSSIPIIMLT 78

                          90       100
                  ....*....|....*....|....*
gi 1233028414  82 AFKEyAFD---SYEVNALDFLLKPI 103
Cdd:cd19937    79 AKGE-EFDkvlGLELGADDYITKPF 102
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 7-102 6.71e-06

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 43.91  E-value: 6.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLrlAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMVP--PSTRVIFTTAFK 84
Cdd:cd19938     3 LIVEDEPKLAQLLIDYLRAAGYA--PTLLAHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIRrfSDVPIIMVTARV 80

                          90       100
                  ....*....|....*....|.
gi 1233028414  85 EyAFD---SYEVNALDFLLKP 102
Cdd:cd19938    81 E-EIDrllGLELGADDYICKP 100
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
 4-69 8.21e-06

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 43.97  E-value: 8.21e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1233028414   4 LTCMIVDDEPLAVKMLEDFVSRTPYLRLAaSFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSR 69
Cdd:cd17530     1 LRVLVLDDDPFQCMMAATILEDLGPGNVD-EADDGREALVILLCNAPDIIICDLKMPDMDGIEFLR 65
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 7-60 9.35e-06

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 41.79  E-value: 9.35e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1233028414    7 MIVDDEPLAVKMLEDFVSRTPYLrlAASFNDPVLALSTLRESPVDVLFLDIQMP 60
Cdd:smart00448   4 LVVDDDPLLRELLKALLEKEGYE--VDEATDGEEALELLKEEKPDLILLDIMMP 55
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 7-116 1.27e-05

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 43.17  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYlRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMVPPS--TRVIFTTAF- 83
Cdd:cd19932     4 LIAEDEALIRMDLREMLEEAGY-EVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSEniAPIVLLTAYs 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1233028414  84 -KEYAFDSYEVNALDFLLKPIRYHKFLGAAEKAR 116
Cdd:cd19932    83 qQDLVERAKEAGAMAYLVKPFSESDLIPAIEMAI 116
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 7-80 2.14e-05

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 42.39  E-value: 2.14e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLRLAAsfNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV----PPSTRVIFT 80
Cdd:cd17569     4 LLVDDEPNILKALKRLLRREGYEVLTA--TSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVreryPDTVRILLT 79
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 7-106 2.68e-05

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 42.39  E-value: 2.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPY--LRLAASFNDpvlALSTLRESPVDVLFLDIQMP-DLDGLNLSRM------VPpstrV 77
Cdd:cd17534     4 LIVEDEAIIALDLKEILESLGYevVGIADSGEE---AIELAEENKPDLILMDINLKgDMDGIEAAREirekfdIP----V 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1233028414  78 IFTTAF-----KEYAFdsyEVNALDFLLKPIRYH 106
Cdd:cd17534    77 IFLTAYsdeetLERAK---ETNPYGYLVKPFNER 107
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 7-102 3.15e-05

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 42.16  E-value: 3.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLRLAASfnDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSR---MVPPSTRVIFTTAF 83
Cdd:cd17553     4 LIVDDQYGIRILLNEVFNKEGYQTFQAA--NGLQALDIVTKERPDLVLLDMKIPGMDGIEILKrmkVIDENIRVIIMTAY 81

                          90       100
                  ....*....|....*....|.
gi 1233028414  84 KEYAF--DSYEVNALDFLLKP 102
Cdd:cd17553    82 GELDMiqESKELGALTHFAKP 102
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 8-127 3.30e-05

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 43.17  E-value: 3.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   8 IVDDEPL---AVKML---EDFVSRTpylrlaasFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNL-SRMV--PPSTRVI 78
Cdd:COG4566     4 IVDDDEAvrdSLAFLlesAGLRVET--------FASAEAFLAALDPDRPGCLLLDVRMPGMSGLELqEELAarGSPLPVI 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1233028414  79 FTT----------AFKEyafdsyevNALDFLLKPIRYHKFLGAAEKA----RQWFEMNSVKEE 127
Cdd:COG4566    76 FLTghgdvpmavrAMKA--------GAVDFLEKPFDDQALLDAVRRAlardRARRAERARRAE 130
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 7-102 3.70e-05

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 41.99  E-value: 3.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLRLAASfnDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMVPPSTRV--IFTTAFK 84
Cdd:cd17619     4 LIVEDEPVTRATLKSYFEQEGYDVSEAG--DGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQSEVgiILVTGRD 81

                          90       100
                  ....*....|....*....|.
gi 1233028414  85 EyAFD---SYEVNALDFLLKP 102
Cdd:cd17619    82 D-EVDrivGLEIGADDYVTKP 101
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 1-64 4.46e-05

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 41.75  E-value: 4.46e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1233028414   1 MKTLTCmivDDEPLAVKMLedfvSRTpylrLAASFNDPVL-------ALSTLRESPVDVLFLDIQMPDLDG 64
Cdd:cd17593     1 MKVLIC---DDSSMARKQL----ARA----LPADWDVEITfaengeeALEILREGRIDVLFLDLTMPVMDG 60
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 7-108 1.38e-04

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 40.30  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLrlAASFNDPVLALSTLRESP--VDVLFLDIQMPDLDGLNL-----SRMVPPstrVIF 79
Cdd:cd17584     2 LVVDDDPTCLAILKRMLLRCGYQ--VTTCTDAEEALSMLRENKdeFDLVITDVHMPDMDGFEFlelirLEMDLP---VIM 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1233028414  80 TTA--FKEYAFDSYEVNALDFLLKPIRYHKF 108
Cdd:cd17584    77 MSAdgSTSTVMKGLAHGACDYLLKPVSIEDL 107
dpiA PRK10046
two-component response regulator DpiA; Provisional
 4-108 1.42e-04

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 41.54  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   4 LTCMIVDDEPLAVKMLEDFVSRTP---YLRLAASFNDPVLALSTLRESpvdVLFLDIQMPDLDGLNLSRMVPPSTR---V 77
Cdd:PRK10046    5 LTLLIVEDETPLAEMHAEYIRHIPgfsQILLAGNLAQARMMIERFKPG---LILLDNYLPDGRGINLLHELVQAHYpgdV 81

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1233028414  78 IFTTAFK--EYAFDSYEVNALDFLLKPIRYHKF 108
Cdd:PRK10046   82 VFTTAASdmETVSEAVRCGVFDYLIKPIAYERL 114
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 34-102 1.60e-04

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 39.74  E-value: 1.60e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1233028414  34 SFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMVPPSTR--VIFTTAfKEYAFDS---YEVNALDFLLKP 102
Cdd:cd19936    27 TYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQKSTlpVIFLTS-KDDEIDEvfgLRMGADDYITKP 99
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
1-101 1.76e-04

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 41.40  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   1 MKTLTCMIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNL---SRMVPPSTRV 77
Cdd:PRK09935    1 MKPASVIIMDTHPIIRMSIEVLLQKNSELQIVLKTDDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFlkrIKQIQSTVKV 80

                          90       100
                  ....*....|....*....|....*.
gi 1233028414  78 IFTTAFKE--YAFDSYEVNALDFLLK 101
Cdd:PRK09935   81 LFLSSKSEcfYAGRAIQAGANGFVSK 106
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 5-102 2.00e-04

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 39.41  E-value: 2.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   5 TCMIVDDEPLAVKMLEDFVSRTPYLRLAASfnDPVLALSTLR-ESPVDVLFLDIQMPDLDGLNLSRMV---PPSTRVIFT 80
Cdd:cd18160     1 TILLADDEPSVRKFIVTTLKKAGYAVTEAE--SGAEALEKLQqGKDIDIVVTDIVMPEMDGIELAREArkiDPDVKILFI 78

                          90       100
                  ....*....|....*....|....
gi 1233028414  81 TAFKEYAF--DSYEVNALDFLLKP 102
Cdd:cd18160    79 SGGAAAAPelLSDAVGDNATLKKP 102
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 5-81 2.71e-04

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 40.78  E-value: 2.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   5 TCMIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDG---LNLSRMVPPSTRVIFTT 81
Cdd:PRK10651    8 TILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGletLDKLREKSLSGRIVVFS 87
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 7-69 3.34e-04

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 39.29  E-value: 3.34e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLRLAAsfNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSR 69
Cdd:cd17627     2 LVVDDDRAVRESLRRSLRFEGYEVETA--VDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCR 62
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 5-103 3.54e-04

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 39.11  E-value: 3.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   5 TCMIVDDEPLAVKMLEDFVSRTPYLRLAASfnDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMVP---PSTRVIFTT 81
Cdd:cd17555     2 TILVIDDDEVVRESIAAYLEDSGFQVLQAA--DGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITkesPDTPVIVVS 79

                          90       100
                  ....*....|....*....|....
gi 1233028414  82 A--FKEYAFDSYEVNALDFLLKPI 103
Cdd:cd17555    80 GagVMSDAVEALRLGAWDYLTKPI 103
PRK15369 PRK15369
two component system response regulator;
1-101 3.80e-04

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 40.45  E-value: 3.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   1 MKTLTCMIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMVP---PSTRV 77
Cdd:PRK15369    1 MKNYKILLVDDHELIINGIKNMLAPYPRYKIVGQVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHqrwPAMNI 80

                          90       100
                  ....*....|....*....|....*.
gi 1233028414  78 IFTTAFKE--YAFDSYEVNALDFLLK 101
Cdd:PRK15369   81 LVLTARQEehMASRTLAAGALGYVLK 106
PRK10360 PRK10360
transcriptional regulator UhpA;
4-95 3.85e-04

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 40.35  E-value: 3.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   4 LTCMIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMVPPSTRVIFTTAF 83
Cdd:PRK10360    2 ITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSVH 81

                          90
                  ....*....|..
gi 1233028414  84 KEYAFDSYEVNA 95
Cdd:PRK10360   82 DSPALVEQALNA 93
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 5-114 3.99e-04

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 38.82  E-value: 3.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   5 TCMIVDDEPLAVKMLEDFVSRTPYLRLAASfnDPVLALSTLRESPVDVLFLDIQMPDLDGLNLS---RMVP--PSTRVIF 79
Cdd:cd17562     2 KILAVDDSASIRQMVSFTLRGAGYEVVEAA--DGRDALSKAQSKKFDLIITDQNMPNMDGIELIkelRKLPayKFTPILM 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1233028414  80 TT-----AFKEYAfdsYEVNALDFLLKPIRYHKFLGAAEK 114
Cdd:cd17562    80 LTtessdEKKQEG---KAAGATGWLVKPFDPEQLLEVVKK 116
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 52-115 4.81e-04

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 38.73  E-value: 4.81e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1233028414  52 VLFLDIQMPDLDGLNL-----SRMVPPStrVIFTTAFKE--YAFDSYEVNALDFLLKPIRYHKFLGAAEKA 115
Cdd:cd17537    47 CLVLDVRMPGMSGLELqdellARGSNIP--IIFITGHGDvpMAVEAMKAGAVDFLEKPFRDQVLLDAIEQA 115
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 4-66 6.15e-04

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 40.60  E-value: 6.15e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1233028414   4 LTCMIVDDEPLAVK----MLEDFVSRTpylrlaASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLN 66
Cdd:PRK11107  668 LTVMAVDDNPANLKligaLLEEQVEHV------VLCDSGHQAVEQAKQRPFDLILMDIQMPGMDGIR 728
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 5-109 1.09e-03

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 37.81  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   5 TCMIVDDEPLAVKMLEDFVSRTPYLRLAASfnDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMVPPSTRV--IFTTA 82
Cdd:cd17594     1 HVLVVDDDAAMRHLLILYLRERGFDVTAAA--DGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRARSDVpiIIISG 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 1233028414  83 FKEYAFD---SYEVNALDFLLKPIRYHKFL 109
Cdd:cd17594    79 DRRDEIDrvvGLELGADDYLAKPFGLRELL 108
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 7-102 1.21e-03

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 37.13  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPY-LRLAASFNDpvlALSTLRESPVDVLFLDIQMPDLDGLNLSRMVP---PSTRVIFTTA 82
Cdd:cd19926     2 LVVDDEPDIRELLEITLGRMGLdVRSARNVKE---ARELLASEPYDLCLTDMRLPDGSGLELVQHIQqrlPQTPVAVITA 78

                          90       100
                  ....*....|....*....|..
gi 1233028414  83 F--KEYAFDSYEVNALDFLLKP 102
Cdd:cd19926    79 YgsLDTAIEALKAGAFDFLTKP 100
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 5-82 1.38e-03

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 37.33  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   5 TCMIVDDEPLAVKMLedfvsrTPYLRLA----ASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV---PPSTRV 77
Cdd:cd17615     1 RVLVVDDEPNITELL------SMALRYEgwdvETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLradGPDVPV 74


                  ....*
gi 1233028414  78 IFTTA 82
Cdd:cd17615    75 LFLTA 79
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 5-103 2.11e-03

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 37.97  E-value: 2.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   5 TCMIVDDEPLAVKMLEDFVSRTPYL-RLAASFNDpvlALSTLRESPVDVLFLDIQMPDLDGLNLSRMV---PPSTRVIFT 80
Cdd:COG4567     6 SLLLVDDDEAFARVLARALERRGFEvTTAASVEE---ALALLEQAPPDYAVLDLRLGDGSGLDLIEALrerDPDARIVVL 82

                          90       100
                  ....*....|....*....|....*...
gi 1233028414  81 TAfkeYAFDSYEVNA-----LDFLLKPI 103
Cdd:COG4567    83 TG---YASIATAVEAiklgaDDYLAKPA 107
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 8-115 2.70e-03

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 36.70  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   8 IVDDEP---LAVK---MLEDFVSRTpylrlaasFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMV---PPSTRVI 78
Cdd:cd17549     3 LVDDDAdvrEALQqtlELAGFRVRA--------FADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIrelDPDLPVI 74

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1233028414  79 FTTAFK--EYAFDSYEVNALDFLLKPIRYHKFLGAAEKA 115
Cdd:cd17549    75 LITGHGdvPMAVEAMRAGAYDFLEKPFDPERLLDVVRRA 113
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 1-82 2.90e-03

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 37.63  E-value: 2.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   1 MKTLTCMIVDDEPLAVKML------EDFVSRTPYLRLAAsfndpvlaLSTLRESPVDVLFLDIQMPDLDGLNLSRMV--- 71
Cdd:PRK11083    1 MQQPTILLVEDEQAIADTLvyalqsEGFTVEWFERGLPA--------LDKLRQQPPDLVILDVGLPDISGFELCRQLlaf 72

                          90
                  ....*....|.
gi 1233028414  72 PPSTRVIFTTA 82
Cdd:PRK11083   73 HPALPVIFLTA 83
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 3-102 3.10e-03

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 37.74  E-value: 3.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   3 TLTCMIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLAlsTLRESPVDVLFLDIQMPDLDGLNLSRM------VPpstr 76
Cdd:PRK10710   10 TPRILIVEDEPKLGQLLIDYLQAASYATTLLSHGDEVLP--YVRQTPPDLILLDLMLPGTDGLTLCREirrfsdIP---- 83

                          90       100
                  ....*....|....*....|....*....
gi 1233028414  77 VIFTTAFKEyAFD---SYEVNALDFLLKP 102
Cdd:PRK10710   84 IVMVTAKIE-EIDrllGLEIGADDYICKP 111
orf27 CHL00148
Ycf27; Reviewed
 7-102 4.34e-03

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 37.39  E-value: 4.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLRLAASfnDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSRMVPPSTRV--IFTTAFK 84
Cdd:CHL00148   10 LVVDDEAYIRKILETRLSIIGYEVITAS--DGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRKESDVpiIMLTALG 87

                          90       100
                  ....*....|....*....|
gi 1233028414  85 EYA--FDSYEVNALDFLLKP 102
Cdd:CHL00148   88 DVSdrITGLELGADDYVVKP 107
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 7-69 4.54e-03

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 35.71  E-value: 4.54e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1233028414   7 MIVDDEPLAVKMLEDFVSRTPYLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLSR 69
Cdd:cd17565     2 YIVDDDKNIIKILSDIIEDDDLGEVVGEADNGAQAYDEILFLQPDIVLIDLLMPGMDGIQLVR 64
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
3-67 6.23e-03

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 37.65  E-value: 6.23e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1233028414   3 TLTCMIVDDEPLAVKMLEDFVSRTPYLrlAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNL 67
Cdd:PRK10841  801 DMMILVVDDHPINRRLLADQLGSLGYQ--CKTANDGVDALNVLSKNHIDIVLTDVNMPNMDGYRL 863
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
4-159 8.61e-03

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 36.41  E-value: 8.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   4 LTCMIVDDEPLAVKMLEDFVSRTPyLRLAASFNDPVLALSTLRESPVDVLFLDIQMPDLDGLNLS---RMVPPSTRVIFT 80
Cdd:PRK09958    1 MNAIIIDDHPLAIAAIRNLLIKND-IEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLetlRKRQYSGIIIIV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414  81 TAFKE--YAFDSYEVNALDFLLKPIRYHKFLGAAEKARQWFEMNSVKEERGSLFVRVDSQ----LRQVEISRILYVTGLK 154
Cdd:PRK09958   80 SAKNDhfYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQQkldsLSKQEISVMRYILDGK 159


                  ....*
gi 1233028414 155 DYVMI 159
Cdd:PRK09958  160 DNNDI 164
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 8-82 9.48e-03

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 35.22  E-value: 9.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233028414   8 IVDDEP---LAVKM-LEDF----VsrtpylRLAASFNDpvlALSTLRESPVDVLFLDIQMPDLDGLNLSRMVP--PSTR- 76
Cdd:cd17552     6 VIDDEEdirEVVQAcLEKLagweV------LTASSGQE---GLEKAATEQPDAILLDVMMPDMDGLATLKKLQanPETQs 76


                  ....*...
gi 1233028414  77 --VIFTTA 82
Cdd:cd17552    77 ipVILLTA 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH