|
Name |
Accession |
Description |
Interval |
E-value |
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
13-383 |
8.40e-59 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 195.84 E-value: 8.40e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 13 LLPVLFAFFVMGFVD-VVGISTSYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLL 91
Cdd:COG0738 10 LIAIYLLFFLWGFATaLWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 92 PFIYYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKvTSMLTLGQFIKAISSTLGPVIAGVAAGLWGN--WHLIFL 169
Cdd:COG0738 90 FALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETA-ASRLNLLHAFFSLGALLGPLLGGLLILLGLSlsWHLPYL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 170 VYAVTTGISWLWLVGTPIAEHKENHGSHVS--NQIWGLLKNTKLILAFSVILLIVGFEIGLMTAVPKYLLERCNMPIEQG 247
Cdd:COG0738 169 ILAVLLLLLALLFLRSKLPEIEEEEEEAAGsaASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 248 GLGCSLYFSARMIGTFVGSILLARYSSRRFLVVNMIAALFVFTIFMISSDGMIILISLFGVGLFCANVFPIVFSMAIQSE 327
Cdd:COG0738 249 ALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGL 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1233026567 328 PSK-ANEISALMIMGVAGGAILPLFMGIIADASNQLFSLFVPLFALVYIFCVSLKMK 383
Cdd:COG0738 329 GKRtAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALK 385
|
|
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
13-381 |
3.57e-49 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 170.87 E-value: 3.57e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 13 LLPVLFAFFVMGFVDVV-GISTSYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLL 91
Cdd:cd17394 1 LALVTSLFFLWGFATNLnDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 92 PF---IYYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAG------------- 155
Cdd:cd17394 81 FIpaaSLRTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSylilsgipstata 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 156 --------VAAGLWGNWHLIFLVYAVTTGISWLWLVGT-----PIAEHKENHGSHVSNQIWGLLKNTKLILAFSVILLIV 222
Cdd:cd17394 161 laamsaaeLQAYKTAELASVQLPYLGIALVLLLLAVLIllsklPEIEAAEAEALGSKGTLLRLLKNPHLRLGVLAIFFYV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 223 GFEIGLMTAVPKYLLE-RCNMPIEQGGLGCSLYFSARMIGTFVGSILLARYSSRRFLVVNMIAALfVFTIFMISSDGMII 301
Cdd:cd17394 241 GAEVAIWSFLINYLMEyIAGLTETSAATFVSYYWGGFMVGRFLGTALLKKISPKKLLAVFALLGL-LLLLGAIFTGGMVA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 302 LISLFGVGLFCANVFPIVFSMAIQSEPSKANEISALMIMGVAGGAILPLFMGIIA-DASNQLFSLFVPLFALVYIFCVSL 380
Cdd:cd17394 320 LYALVLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLVMAIVGGAVVPLIQGAVAdDAAGLRIAFLVPLLCFAYILFYGL 399
|
.
gi 1233026567 381 K 381
Cdd:cd17394 400 R 400
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
13-349 |
2.48e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 99.66 E-value: 2.48e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 13 LLPVLFAFFVMGF-VDVVGISTSYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLL 91
Cdd:COG2814 12 LLALALGAFLSGLgIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 92 PFIYYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLWGnWHLIFLVY 171
Cdd:COG2814 92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWVFLVN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 172 AVTTGISWLWLVGTpIAEHKENHGSHVSNQIWGLLKNTKLILAFSVILLIVGFEIGLMTAVPKYLLERCNMPIEQGGLGC 251
Cdd:COG2814 171 AVLALLALLLLLRL-LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 252 SLYFSARMIGTFVGSILLARYSSRRFLVVNMIAALFVFTIFMISSDGMIILISLFGVGLFCANVFPIVFSMAIQSEPSKA 331
Cdd:COG2814 250 ALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEA 329
|
330
....*....|....*....
gi 1233026567 332 -NEISALMIMGVAGGAILP 349
Cdd:COG2814 330 rGRASGLYNSAFFLGGPLA 348
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
16-373 |
8.54e-22 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 95.47 E-value: 8.54e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 16 VLFAFFVMGFVD-VVGISTSYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLLPFI 94
Cdd:cd17333 1 LYISFFSNGLTDaLLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 95 YYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLgQFIKAISSTLGPVIAGvAAGLWGNWHliFLVYAVT 174
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVL-HGFFGLGALIGPLIAT-SLLTSELSW--SWAYLII 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 175 TGISWLWLVGTPIAEHKENHGSHVSNQIWG--------LLKNTKLILAFSVILLIVGFEIGLMTAVPKYLLERCNMPIEQ 246
Cdd:cd17333 157 GLIYLLLAILILLTLFPELPSARNPQQSVGafsasasrLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 247 GGLGCSLYFSARMIGTFVGSILLARYSSRRFLVVNMIAALFVFTIFMISSDGMIILISLFGVGLFCANVFPIVFSMAIQS 326
Cdd:cd17333 237 AGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISN 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1233026567 327 EP-SKANEISALMIMGVAGGAILPLFMGIIADASN-QLFSLFVPLFALV 373
Cdd:cd17333 317 LPyAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGiQTAMLLITILYAI 365
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
16-378 |
1.60e-19 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 89.16 E-value: 1.60e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 16 VLFAFFVMGFVDVVGISTSYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLLPFIY 95
Cdd:COG2807 24 VLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 96 YSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSkDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLWGnWHLIFLVYAVTT 175
Cdd:COG2807 104 PSVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALG-WRGALAVWALLA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 176 GIS---WLWLVGTPIAEHKENHGSHVSNQIWGLLKNTKLILAFSVILLIVgfeIGLMTAVPKYLLERcNMPIEQGGLGCS 252
Cdd:COG2807 182 LLAlllWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLY---YAVVAWLPPILRDA-GLSAATAGLLLS 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 253 LYFSARMIGTFVGSILLARYSSRRFLVVNMIAALFVFTIFMISSDGMIILISLFGVGLFCANVFPIVFSMAIQ--SEPSK 330
Cdd:COG2807 258 LFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLraRTPAE 337
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1233026567 331 ANEISALMIM-GVAGGAILPLFMGIIADASNQLFSLFVPLFALVYIFCV 378
Cdd:COG2807 338 AAALSGMAQSvGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLV 386
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-380 |
6.57e-17 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 81.07 E-value: 6.57e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 11 RKLLPVLFAFFVMGFVDVVGIST--SYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIA 88
Cdd:COG2271 9 WRILALLFLAYFLNYLDRSNLSVaaPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 89 MLLPFIYYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLWGnWHLIF 168
Cdd:COG2271 89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-WRAAF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 169 LVYAVTTGiswlwlvgtpiaehkenhgshvsnqIWGLLkntKLILAFSVILLIVGFEIGLMTAVPKYLLERCNMPIEQGG 248
Cdd:COG2271 168 LILGLPGL-------------------------LLALL---RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 249 LGCSLYFSARMIGTFVGSILLARYSSRR--FLVVNMIAALFVFTIFMISSDGMIILISLFGVGLFCANVFPIVFSMAIQS 326
Cdd:COG2271 220 LLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAEL 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1233026567 327 EPSK--ANEISALMIMGVAGGAILPLFMGIIADASN-QLFSLFVPLFALVYIFCVSL 380
Cdd:COG2271 300 FPKKarGTASGLVNTFGFLGGALGPLLVGYLLDATGyQAAFLLLAALALLAALLALL 356
|
|
| gluP |
TIGR01272 |
glucose/galactose transporter; This model describes the glucose/galactose transporter in ... |
95-375 |
1.15e-16 |
|
glucose/galactose transporter; This model describes the glucose/galactose transporter in bacteria. This belongs to the larger facilitator superfamily. Disruption of the loci leads to the total loss of glucose or galactose uptake in E.coli. Putative transporters in other bacterial species were isolated by functional complementation, which restored it functional activity. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273531 [Multi-domain] Cd Length: 310 Bit Score: 79.94 E-value: 1.15e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 95 YYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGV---------------AAG 159
Cdd:TIGR01272 7 QRYYVLFLGALFVLASGLTILQVAANPYVSILGPIETAASRLALTQAFNKLGTTVAPLFGGSlilsgagdlsmqvatANA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 160 LWGNWHLIFLVYAVTTGISWLWLVGTPIAEHKENHGSHVSN----QIWGLLKNTKLILAFSVILLIVGFEIGLMTAVPKY 235
Cdd:TIGR01272 87 EAAKVHTPYLLLAGALAVLAIIFAFLPLPELQEADVARVSSgdttQKTSAFQFTHLVLGALGIFVYVGAEVSAGSFLVNF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 236 LLER--CNMPIEQGGLGCSLYFSARMIGTFVGSILLARYSSRRFLVVNMIAALFVFTIFMISSdGMIILISLFGVGLFCA 313
Cdd:TIGR01272 167 LSDPhaLGLPEDQAAHFTAYTWGGAMVGRFIGSAVMPMISQGRYLAFNAFLAVLLSIGAALTH-GYVAMWFVLALGLFNS 245
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1233026567 314 NVFPIVFSMAIQSEPSKANEISALMIMGVAGGAILPLFMGIIADASNQLFSLFVPLFALVYI 375
Cdd:TIGR01272 246 IMFPTIFSLALNALGRHTSQGSGILCLAIVGGAIVPLLQGSLADCLGIQLAFALPVPCYLYI 307
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
16-380 |
9.56e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 77.85 E-value: 9.56e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 16 VLFAFFVMGFV-DVVGISTSYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLLPFI 94
Cdd:cd06174 1 LLLGFFLTGLArGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 95 YYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAG-VAAGLWGNWHLIFLVYAV 173
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGiLASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 174 TTGISWLWLV-------GTPIAEHKENHGSHVSNQIWGLLKNTKLILAFSVILLIVGFEIGLMTAVPKYLLERCNMPIEQ 246
Cdd:cd06174 161 LALLAAILLLlvvpdppESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 247 GGLGCSLYFSARMIGTFVGSILLARYSSRR-FLVVNMIAALFVFTIFMISSDGMIILISLFGVGLFCANVFPIVFSMAIQ 325
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKpLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1233026567 326 SEP--SKANEISALMIMGVAGGAILPLFMGIIADASNQLFSLFVPLFALVYIFCVSL 380
Cdd:cd06174 321 LFPpeIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
40-376 |
2.12e-15 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 76.83 E-value: 2.12e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 40 FGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLLPFIYYSFVSVLMAFALLGIGNTILQVSl 119
Cdd:cd17478 26 LGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPE- 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 120 NPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLWGNWH-LIFLVYAVTTGISWLWLVGTPIAEHKENHGSHV 198
Cdd:cd17478 105 GARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGlLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 199 SNQIWGLLKNTKLILAFSVILLIVGFEIGLMTAVPKYLLERcNMPIEQGGLGCSLYFSARMIGTFVGSILLARYSSRRFL 278
Cdd:cd17478 185 SARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQR-GYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVI 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 279 VVNMIAALFvFTIFMISSDGMIILISLFGVGLFCANVFPIVFSMAIQSEPSKANEISALMI-MGVAGGAILPLFMGIIAD 357
Cdd:cd17478 264 IASLLLAAP-FLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMgLSFGLGGIGAPVLGALAD 342
|
330 340
....*....|....*....|...
gi 1233026567 358 ASN----QLFSLFVPLFALVYIF 376
Cdd:cd17478 343 AFGlesvLLILALLPLLGALLAF 365
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
16-348 |
6.25e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 75.15 E-value: 6.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 16 VLFAFFVMGFVDVVGISTSYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLLPFIY 95
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 96 YSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLWGnWHLIFLVYAVTT 175
Cdd:pfam07690 83 SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 176 GIS-WLWLVGTPIAEHKENHGSHVSNQI----WGLLKNTKLILAFSVILLIVGFEIGLMTAVPKYLLERcNMPIEQGGLG 250
Cdd:pfam07690 162 LLAaVLLLLPRPPPESKRPKPAEEARLSlivaWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 251 CSLYFSARMIGTFVGSILLARYSSRRFLVVNMIAALFVFTIFMISS---DGMIILISLFGVGLFCANVFPIVFSMAIQS- 326
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSltlSSLWLLLALLLLGFGFGLVFPALNALVSDLa 320
|
330 340
....*....|....*....|..
gi 1233026567 327 EPSKANEISALMIMGVAGGAIL 348
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGAL 342
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-378 |
8.42e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 75.30 E-value: 8.42e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 11 RKLLPVLFAFFVMGFVDVVGIST--SYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIA 88
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVlaPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 89 MLLPFIYYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLWGnWHLIF 168
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG-WRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 169 LVYAVTTGIS--WLWLVGTPIAEHKENHGSHVSNQIWGLLKNTKLILAFSVILLIVGFEIGLMTAVPKYLLERCNMPIEQ 246
Cdd:COG2223 163 LILGILLLVVavLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAAT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 247 GGLGCSLYFSARMIGTFVGSILLARYSSRR-FLVVNMIAALFVFTIFMISSDGMIILISLFGVGLFCANVFPIVFSMAIQ 325
Cdd:COG2223 243 AGLLAALFALLGALGRPLGGWLSDRIGGRRvLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPD 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1233026567 326 SEPSK-ANEISALMIMGVA-GGAILPLFMGIIADASNQLFSLFVpLFALVYIFCV 378
Cdd:COG2223 323 IFPTKnAGAVYGLVGAAGGlGGFLGPLLFGALLDATGSYTAAFL-VFAVLALVAL 376
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
38-348 |
1.27e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 71.43 E-value: 1.27e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 38 NDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLLPFIYYSFVSVLMAFALLGIGNTILQV 117
Cdd:cd17324 27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 118 SLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLWGnWHLIFLVYAVTTGISWLWLV-GTPIAEHKENHGS 196
Cdd:cd17324 107 IAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAAFLAIAVLALLAALLLWrLLPSLPPKKPGSL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 197 HVSNQIWGLLKNTKLILAFSVILLIVGFEIGLMTAVPKYLLERCNMPIEQGGLGCSLYFSARMIGTFVGSILLARYSSRR 276
Cdd:cd17324 186 GLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRA 265
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1233026567 277 FLVVN--MIAALFVFTIFMISSDGMIILISLFGVGLFCANvfPIVFSMAIQSEPSKANEISALMI----MGVAGGAIL 348
Cdd:cd17324 266 LLIALllLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAH--SALQTRVLRLAPEARGLASSLYLaaynLGGALGAAL 341
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
16-382 |
5.31e-13 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 69.52 E-value: 5.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 16 VLFAFFVMGF-VDVVGISTSYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLLPFI 94
Cdd:cd17474 4 VFFATLLAVLgVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 95 YYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLWgnWHLIFLVYAVT 174
Cdd:cd17474 84 SDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAIS--WRYPFFLLAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 175 TGIS-WLWLVGTPIAEHKENHGSHVSNQIWGLLKNTKLILAFSVI--LLIVGFeIGLMTAVPKYLLERCNMPIEQGGLGC 251
Cdd:cd17474 162 IPVAfLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSafLYFFLY-FAFLTYLPFLLELLYGISPIIIGLLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 252 SLYFSARMIGTF-VGSILLARYSSRRFLVVNMIAALFVFTIFMISSDGMIILISLFGVGLFCANVFPIVFSMAIQSEPS- 329
Cdd:cd17474 241 AGWSVLLALGSLfVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEe 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1233026567 330 -KANEISALMIMGVAGGAILPLFMGIIADASNqLFSLFVPLFALVYIFCVSLKM 382
Cdd:cd17474 321 eRGTASSLYNFVRFLGQAVGPLLFGLLLEIFG-LSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
14-358 |
8.59e-13 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 69.19 E-value: 8.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 14 LPVLFAFFVMGFVDVVGISTSY--VKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLL 91
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLpdIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 92 -PFIYYsFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLWGNWHLIFLV 170
Cdd:cd17328 81 sSFAPN-FWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 171 YA---VTTGISWLWLVGTP---IAEHKENHGSHVSNqIWGLLKNTKLILAFSVILL---IVGFEIGLMTA-VPKYLLeRC 240
Cdd:cd17328 160 TGvlgVLLAILLLLFVREPprgAAEGGVMAKSTATS-FLADLKALAKNPSFILSTLgftAVSFVTGALAFwAPTFFL-RA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 241 NMPIEQGGLGCSLYFS-----ARMIGTFVGSIL---LARYSSRRFLVVNMIAAL----FVFTIFMISSDGMIILISLFGV 308
Cdd:cd17328 238 FGVGDLSSADVGLIFGaitciAGVLGVLLGGILadrLRRKTPRADPLVCAVGLLaaapFLFLALVLALSNLLLAWVLLFL 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1233026567 309 GLFCAN-----VFPIVFSMAIQSEPSKANEISALMIMgVAGGAILPLFMGIIADA 358
Cdd:cd17328 318 GEFLLSlnwapVFAILLYVVIPTRRSTASAIQILLSH-LLGDAGSPYLIGLISDL 371
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
20-358 |
2.72e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 67.22 E-value: 2.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 20 FFVMGFVDVVGIST------SYVKnDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLLPF 93
Cdd:cd17325 1 LSLALFLDMLGYGIiipilpLYAE-SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 94 IYYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLWGnWHLIFLVYAV 173
Cdd:cd17325 80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 174 TTGIS----WLWLVGTPIAEHKENHGSHVSNQIWGLLKNTKLILAFSVILLIVGFEIGLM-TAVPKYLLERCNMPIEQGG 248
Cdd:cd17325 159 LALLAlvlaLLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALePFLPLYAAELGGLSPAQIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 249 LGCSLYFSARMIGTFVGSILLARYSSRRFLVVNMIAALFVFTIFMISSDGMIILISLFGVGLFCANVFPIVFSMAIQSEP 328
Cdd:cd17325 239 LLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVP 318
|
330 340 350
....*....|....*....|....*....|..
gi 1233026567 329 SKANE--ISALMIMGVAGGAILPLFMGIIADA 358
Cdd:cd17325 319 PEGRGtaMGLFNTAFSLGMVLGPLLGGFLYDA 350
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
66-382 |
2.55e-11 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 64.56 E-value: 2.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 66 GLLMGHIGRKKTVLLSALITGIAMLLPFIYYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKAI 145
Cdd:PRK03699 63 AWLMEIIPLKRQLIFGFALMILAVAGLMFSHSLALFSIAMFVLGVVSGITMSIGTFLITHVYEGKQRGSRLLFTDSFFSM 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 146 SSTLGPVIAGVAAGLWGNWHLIFL---VYAVTTGISWLWLVGTPIAEHKENHGSHVSNQIWGLlknTKLILAFSVILLIV 222
Cdd:PRK03699 143 AGMIFPIIAAYLLARSIEWYWVYAcigLVYVAIFILTLFSEFPALGKHAPKADKPVAKEKWGI---GVLFLAIAALLYIL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 223 GfEIGLMTAVPKYLLERCNMPIEQGGLGCSLYFSARMIGTFVGSILLARYSSRRFLVVNMIAALFVFTIFMISSDGMIIL 302
Cdd:PRK03699 220 A-QLTFISWVPEYAQKKFGMSLEDAGNLVSNFWMAYMVGMWIFSFIVRFFDLQRILTVLAGLALVLMYLFVNTDDPSHLL 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 303 ISLFGVGLFCANVFPIVFSMAI-QSEPSKANEISALMIMGVAGGAILPLFMGIIadasNQLFSLFVPLFALVYIFCVSLK 381
Cdd:PRK03699 299 YAILGLGFFSSAIYTTIITLGSqQTKVASPKLVNFILTCGTIGTMLTFVVTSPI----VAHFGLQAALLTANGLYAVVFV 374
|
.
gi 1233026567 382 M 382
Cdd:PRK03699 375 M 375
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
13-380 |
3.65e-11 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 63.74 E-value: 3.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 13 LLPVLFAFFVMGFVD--VVGISTSYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAML 90
Cdd:cd17319 4 IIPLLFLAYVINYLDrvNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 91 LPFIYYSFVSVLMAFALLGI---GNTILQVSLNPLLLDVVSKDKVTSMLTLGQfikAISSTLGPVIAGVAAGLWGnWHLI 167
Cdd:cd17319 84 LTGFATSLTSLYVLRFLLGVaeaGFFPGAIKALAEWFPARERGRATGLFNSGA---PLGAAIGPPLSGWLLLLFG-WRWA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 168 FLVYAVTT---GISWLWLVGtpiaehkenhgshvsnQIWGLLkntkliLAFSVILLIVGfeiGLMTAVPKYLLERCNMPI 244
Cdd:cd17319 160 FIIEGLLGlllAVLWWFYLR----------------QVWGLA------LGYFGINYALY---GLLTWLPTYLKQARGFSL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 245 EQGGLGCSLYFSARMIGTFVGSILLARYS--SRRFLVVNMIAALFVFTIFMISSDGMIILISLFGVGLFCANVFPIVFSM 322
Cdd:cd17319 215 KQVGLLAAIPFLAGAIGMILGGRLSDRLLrgARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWS 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1233026567 323 AIQSEPSKANEISALMIMGVAG---GAILPLFMGIIADASNQLFSLFVPLFALVYIFCVSL 380
Cdd:cd17319 295 LPADLLPGEAAATAGGLINSGGnlgGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLV 355
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
44-366 |
5.61e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 63.36 E-value: 5.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 44 DTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLLPFIYYSFVSVLMAFALLGIGNTILQVSLNPLL 123
Cdd:cd17473 34 ELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 124 LDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLwgNWHLIFLVYAVTTGI---SWLWLVGTPIAEHKENHGSHVSN 200
Cdd:cd17473 114 GDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI--GWRAPFLVYLLALPVlilVLLFLPEPARKSKSAASPGAATA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 201 QiwGLLKNTKLILAFSVILLIVGFEIgLMTAVPKYLLERCNMPIEQGGLGCSLYFSARMIGTFVGSILLARYSSRRFLVV 280
Cdd:cd17473 192 A--ALPWKRVLPIYFLAFLAMLLFYV-IPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 281 NMIAALFVFTIFMISSDGMIILISLFGVGLFCANVFPIVFSMAIQ-SEPSKANEISALMIMGVAGGAIL-PLFMGIIADA 358
Cdd:cd17473 269 GFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSlVPPELRGRAMGIVTSAFFLGQFLsPLVLGPLVNL 348
|
....*...
gi 1233026567 359 SNQLFSLF 366
Cdd:cd17473 349 TGGLSGAF 356
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
14-379 |
7.99e-11 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 63.05 E-value: 7.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 14 LPVLFAFFVMGFVDVV-GISTSYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLLP 92
Cdd:cd17393 2 LAVAAFFFINGILMASwATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 93 FIYYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLgqfiKAISST---LGPVIAGVAAGLWGNWHLIFL 169
Cdd:cd17393 82 GLAPSVPALALALFLFGAANGALDVAMNAQGVAVERAYGRPIMSSL----HAMWSLgglAGALLGAAAIGAGVSPGVHLL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 170 VYAVT------TGISWLWLVGTPIAEHKENHGSHVsnqiwGLLKNTKLILAFSVILLIVGFEIGLMTAVPKYLLERCN-M 242
Cdd:cd17393 158 AAAVLlllaalVAIRALLPGTGEAAEDRPDGAGKP-----GFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLgA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 243 PIEQGGLGCSLYFSARMIGTFVGSILLARYSSRRFLVVNMIAALFVFTIFMISSDGMIILISLFGVGLFCANVFPIVFSM 322
Cdd:cd17393 233 SAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSA 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1233026567 323 AIQSEPSKANE-ISALMIMGVAGGAILPLFMGIIADASNQLFSLFVPLFALVYIFCVS 379
Cdd:cd17393 313 AGALPGLAAGIaVARVATLGYLGFLVGPPLIGFLADATGLRTAFLVVALLALLVALLA 370
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
43-356 |
1.69e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.86 E-value: 1.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 43 NDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLS-ALITGIAMLLPFIYY----SFVSVLMAFALLGIGNTILQV 117
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdLLRALLAAVLALLALlgslSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 118 SLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLWGNwHLIFLVYAVTTGISWLWLVGTPIAEHKENHGSH 197
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGP-GGAFAINALSFLLSALLLLFIRRPPPAAPGESS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 198 VSNQ------IWGLLKNTKLILAFSVILLIVGFEIGLMTAVPKYLLERCNMPIEQGGLGcslyFSARMIGTFVGSILLAR 271
Cdd:cd06173 191 SLLLrdlregLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLL----LAAFGVGALLGALLLGR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 272 YSSRRFLVVNMIAALFVFTIFMI----SSDGMIILISLFGVGLFCANVFPIVFSMAIQS-EPSKANEISALMIMGVAGGA 346
Cdd:cd06173 267 LSKRRRRGRLLLIGALLLGLALLvlglSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRvPDELRGRVFSVYNALNSGAM 346
|
330
....*....|
gi 1233026567 347 ILPLFMGIIA 356
Cdd:cd06173 347 PLGALLAGLL 356
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
16-348 |
8.67e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 59.88 E-value: 8.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 16 VLFAFFVMGFVDVVGISTSYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLLPFIY 95
Cdd:cd17321 2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 96 YSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLWGnWHLIFLVYAVTT 175
Cdd:cd17321 82 PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFG-WRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 176 GISWLWlvgtpiaehkenhgshvsnqiwgllknTKLILAFSVILLIVGF-EIGLMTAVPKYLLERCNMPIEQGGLGCSLY 254
Cdd:cd17321 161 LVALLL---------------------------ARTFSGAVLAAFLLGAaLGGLLFLLPLYLQGVLGYSPLQAGLALLPL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 255 FSARMIGTFVGSILLARYSSRRFLVVNM-IAALFVFTIFMISSDG----MIILISLFGVGLfcANVFPIVFSMAIQS-EP 328
Cdd:cd17321 214 ALAMLVAAPLAGRLADRFGPRLVLVAGLlLTAVGLLLLALLGADSsvwlLLPGLVLLGLGL--GLFATPLTNAALSSvPK 291
|
330 340
....*....|....*....|
gi 1233026567 329 SKANEISALMIMGVAGGAIL 348
Cdd:cd17321 292 EKAGAASGILNTARQLGGAL 311
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-162 |
1.85e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 58.74 E-value: 1.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 15 PVLFAFFVMGFVDVVGISTS------YVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIA 88
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALepflplYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1233026567 89 MLLPFIYYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLWG 162
Cdd:cd17325 279 LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
74-322 |
6.94e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.22 E-value: 6.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 74 RKKTVLLSALITGIAMLLPFI------YYSFVSVLMAFALLGIGNTILQVSLNPLLLDVV-SKDKVTSMLTLGQFIKAIS 146
Cdd:COG2211 80 RRPWILIGAIPLALSFVLLFTapdlspTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTpDYEERTRLSSWRFAFAGLG 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 147 STLGPVIAGVAAGLWG-----NWHLIFLVYAVTTGISWLWLV-GTPIAEHKENHGSHVSNQIWGLLKNTKLILAFSVILL 220
Cdd:COG2211 160 GLLASVLPPPLVAAFGgdaalGYRLTALIFAVLGLLAFLLTFfGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLL 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 221 IVGFEIGLMTAVPKYLLERCNMPIEQGGLGCSLYFSARMIGTFVGSILLARYSSRRFLVVNMI--AALFVFTIFMISSDG 298
Cdd:COG2211 240 FFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLlaALGLLLLFFLGPGNL 319
|
250 260
....*....|....*....|....
gi 1233026567 299 MIILISLFGVGLFCANVFPIVFSM 322
Cdd:COG2211 320 WLLLVLAALAGIGLGAILVLPWAM 343
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
18-360 |
1.01e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 56.48 E-value: 1.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 18 FAFFVMGfvdvVGISTSYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLLPFIYYS 97
Cdd:cd17475 8 ASLVAQG----IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 98 FVSVLMAFALLGIGNTILQVSLNPLLLDVVSK-DKVTSM------LTLGqfiKAISSTLGPVIAGVAaglwgNWHLIFLV 170
Cdd:cd17475 84 YPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPrERGLAMgirqtgVPLG---GALAAALLPPLALHY-----GWRAAFVV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 171 YAV----TTGISWLWLVGTPIAEHKENHGSHVSNQIWGLLKNTKLILAFSVILLIVGFEIGLMTAVPKYLLERCNMPIEQ 246
Cdd:cd17475 156 AGLvsilAAVLFWLFYREPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 247 GGlgcsLYFSARMIGTFVGSILLARYSSRRF----------LVVNMIAALFVFTIFMISSDGMIILISLFGVGLFCANVF 316
Cdd:cd17475 236 AG----ALLAVAQLGGALGRIGLGRVSDRVFggrrrpvlviTAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWN 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1233026567 317 PIVFSM-AIQSEPSKANEISALMIMGVAGG-AILPLFMGIIADASN 360
Cdd:cd17475 312 GLYLTLvAESAGPEQAGTALGLANTINFIGiAIGPPLFGLLVDATH 357
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
39-376 |
3.67e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 54.49 E-value: 3.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 39 DFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLLPFIYYSFVSVLMAFALLGIGNTILQVS 118
Cdd:cd17477 25 REGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 119 LNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAglwGNWHLIFLVYAVTTGISWLWLVGTPIAEHKENHGSHV 198
Cdd:cd17477 105 SESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVG---TAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAESI 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 199 SnqIWGLLKntKLILAFSVILLIVGFEIGLMTAVPKYLLeRCNMPIEQGGLGCSLYFSARMIGTFVGSILLARYSSRRFL 278
Cdd:cd17477 182 S--LRRLLR--IAPLALLGAFVAGFLEGAFYSLLPLYGL-RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 279 VVNM-IAALFVFTIFMISSDGMIILISLFGVGLFCANVFPIVFSMAIQS-EPSKANEISALMIMGVAGGAIL-PLFMGII 355
Cdd:cd17477 257 LGCAlLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRlPGDELVAANAALLLLYGLGSVIgPLLAGAL 336
|
330 340
....*....|....*....|..
gi 1233026567 356 ADA-SNQLFSLFVPLFALVYIF 376
Cdd:cd17477 337 MDAfGPHGLFLFLAAVALLFLL 358
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
38-380 |
1.05e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 53.35 E-value: 1.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 38 NDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLLPFIYYSFVSVLMAFALLGIGNTILQV 117
Cdd:cd17320 27 RDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 118 SLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIaGVAAGLWGNWHLIFLVYAVTTGI----SWLWLVGTPIAEHKEN 193
Cdd:cd17320 107 VARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLL-GGLLLLFFGWRAIFVFLALLGLLllllVLLFLPETLPEEKRKP 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 194 HGSHVSNQIWGLLKNTKLILAFSVILLIVGFEIGLMTAVPKYLLERCNMPIEQGGLGCSLYFSARMIGTFVGSILLARYS 273
Cdd:cd17320 186 LLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFG 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 274 SRRFLVVNMI-----AALFVFTIFMISSDGMIILISLFGVGLFCANVFPIVFSMAIQSEPSKANEISALM-IMGVAGGAI 347
Cdd:cd17320 266 PRRLLRLGLLlllaaALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLgFLQFLIGAL 345
|
330 340 350
....*....|....*....|....*....|...
gi 1233026567 348 LPLFMGIIADASNQLFSLFVPLFALVYIFCVSL 380
Cdd:cd17320 346 AGALVGLLPNGTALPMGLLILVLGLLALLLLIL 378
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
7-192 |
1.55e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.98 E-value: 1.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 7 NKSVRKLLpVLFAFFVMGFVDVVGISTSYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITG 86
Cdd:COG2211 227 NRPFLLLL-LAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 87 IAMLLPFIYY--SFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTS-------MLTLGQFIKAISSTLGPVIAGV- 156
Cdd:COG2211 306 LGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrreglYFGIFTFAIKLGQALAGALAGLl 385
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1233026567 157 -------------AAGLWGNWHLIFLVYAVTTGISWLWLVGTPIAEHKE 192
Cdd:COG2211 386 lalfgyvagaaqsPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERH 434
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
31-357 |
1.70e-07 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 52.76 E-value: 1.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 31 ISTSYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLLpfiyYSFVSVLMAFALLGI 110
Cdd:TIGR00881 16 LAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLF----FGFSTSLWVMAALWA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 111 GNTILQVSLNPLLLDVVSK-------DKVTSMLTLGQFIKAIsstLGPVIAGVAAGLWGNWHLIFLV---YAVTTGISWL 180
Cdd:TIGR00881 92 LNGIFQGMGWPPCGRTVTKwfsrserGTWVSFWNCSHNVGGG---LLPPLVLFGIAELYSWHWVFIVpgiIAIIVSLICF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 181 WL-------VGTPIAEHKENHGSHVSNQ------------IWGLLKNTKLILAFSVILLIVGFEIGLMTAVPKYLLERCN 241
Cdd:TIGR00881 169 LLlrdspqsCGLPPAEEMPNEEPDGDAEkkeeeltkkqifLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 242 MPIEQGGLGCSLYFSARMIGTFVGSILLAR-YSSRRFLV-----VNMIAALFVFTIFMISSDGMIIlISLFGVGLFcANV 315
Cdd:TIGR00881 249 FSKEKASWAFTLYELGGLVGTLLAGWLSDKlFNGRRGPLavffmALIIVSLLVYWLNPAANPLMDL-ICLFALGFL-VYG 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1233026567 316 FPIVFSM-AIQSEPSKANEISALMI--MGVAGGAILPLFMGIIAD 357
Cdd:TIGR00881 327 PQMLIGViASELAPKKAAGTAAGFVgfFAYLGGILAGLPLGYLAD 371
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
11-294 |
6.75e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 50.69 E-value: 6.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 11 RKLLPVLFAFFVMGFVDVVGISTSYVKNDFGLNDTLANLlpmmVFLWFAVCSLPTGLLMGHI----GRKKTVLLSALITG 86
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGL----VLALSAVAGIVASLIGGRLadrfGRKPVMLAGLLLRA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 87 IAMLLPFIYYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLWGNWhl 166
Cdd:cd17329 77 LGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRL-- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 167 IFLVYAVTTGIS--WLWLVGTPIAEHKENHGSHVSNQIWGLLKNTKLILAFSVILLIVGF-EIGLMTAVPKYLLERCNMP 243
Cdd:cd17329 155 LFLAAAVLFLLAalVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLiYFQLESTLPVYVVEILGLG 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1233026567 244 IEQGGlgcsLYFSARMIGTFVGSILLARYSSRRFLVVNMIAALFVFTIFMI 294
Cdd:cd17329 235 ESLLG----LLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFA 281
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-183 |
1.06e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 50.26 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 13 LLPVLFAFFVMGFVDVVGISTSYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAM-LL 91
Cdd:COG2223 209 LLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLlLL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 92 PFIYYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLWGNWHLIFLVY 171
Cdd:COG2223 289 ALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVF 368
|
170
....*....|..
gi 1233026567 172 AVTTGISWLWLV 183
Cdd:COG2223 369 AVLALVALVLTL 380
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
50-374 |
2.80e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 48.74 E-value: 2.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 50 LPMMVFLWFAVCSLP-TGLLMGHIGRKKTVLLSALITGIAMLLPFIYYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVS 128
Cdd:cd17489 35 LVVGLFTLAALLARPfAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 129 KD---KVTSMLTLGQFIKAIsstLGPVIAGVAAGLWGNWhLIFLVYAVTTGISWLWLVGTPIAEHKENHGSHVSNQIWGL 205
Cdd:cd17489 115 PSrrgEGIGYYGLATTLAMA---LGPALGLFLYQHLGFA-VLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRR 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 206 LKNtKLILAFSVILLIVGFEIG-LMTAVPKYLLERcnmPIEQGGLGCSLYFSARMIGTFVGSILLARYSSRRFLVVNMIA 284
Cdd:cd17489 191 LVE-KKVLPPALILFLASIAYGaISTFLPLYAAER---GISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 285 ALFVFTIFMISSDGMIILISLFGVGLFCANVFPIVFSMAIQ-SEPSKANEISALMIMGVAGG-AILPLFMGIIADASNQ- 361
Cdd:cd17489 267 LALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDlVPPHRRGAANGTFFIFFDLGiGLGGLLLGLVAELFGYr 346
|
330
....*....|....*.
gi 1233026567 362 ---LFSLFVPLFALVY 374
Cdd:cd17489 347 amfLLAAVVVLLALVL 362
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
29-376 |
1.30e-05 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 46.80 E-value: 1.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 29 VGISTSYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLLPfIYYSFVSVLMAFALL 108
Cdd:cd17339 18 VGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLR-SLGGIALLFLGTALA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 109 GIGNTILQVslnplLLDVVSKDK-------VTSMLTLG-QFIKAISSTLGPVIAGVAAGLWGNWHLIFLVYAVTTGISWL 180
Cdd:cd17339 97 GAGIAVGNV-----LLPSLIKRDfprrvglMTGLYTTSmNLGAALASGLSVPLAQALGGGWRGALAIWALPALLALLIWL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 181 WLV-GTPIAEHKENHGSHVSnqiwgLLKNTkliLAFSVIL---LIVGFEIGLMTAVPKYLLERcNMPIEQGGLGCSLYFS 256
Cdd:cd17339 172 PQLrRRKRAAAAAAPLTKIS-----VWRSP---LAWQVTLfmgLQSLLFYTLMAWLPTILIDA-GLSAATAGWLLSLFQL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 257 ARMIGTFVGSILLARYSSRRFLVVNMIAALFV-FTIFMISSDGMIIL-ISLFGVGLFCAnvFPIVFSMAIQSEPSKAnEI 334
Cdd:cd17339 243 VGIPASLLVPILATRLKNQRPIVVLLAVLFIIgVLGLLFAPTALALLwAVLLGLGGGAA--FSLALTLISLRSSDPA-EA 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1233026567 335 SALMIMGVAGGAIL----PLFMGIIADASNQLFSLFVPLFALVYIF 376
Cdd:cd17339 320 AALSGMAQSVGYLLaalgPLLFGVLHDLTGSWTAPLVLLLALTVLQ 365
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
13-295 |
1.51e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 46.34 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 13 LLPVLFAFFVMGF-VDVVGISTSYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLL 91
Cdd:COG0477 16 LLALALGTFLEGLdFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 92 PFIYYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLWGnWHLIFLVY 171
Cdd:COG0477 96 CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG-WRWIFLIN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 172 AVttgISWLWLVGTPIAEHKENHGSHVSNQIWGLLKNTKLILAFSVILLIVGFEIGLMTAVPKYLLERCNMPIEQGGLGC 251
Cdd:COG0477 175 AP---LGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1233026567 252 SLYFSARMIGTFVGSILLARYSSRRFLVVNMIAALFVFTIFMIS 295
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| PRK10133 |
PRK10133 |
L-fucose:H+ symporter permease; |
254-376 |
1.11e-04 |
|
L-fucose:H+ symporter permease;
Pssm-ID: 182260 [Multi-domain] Cd Length: 438 Bit Score: 44.11 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 254 YFSARM----IGTFVGSILLARYSSRRFLVVNMIAALfVFTIFMISSDGMIILISLFGVGLFCANVFPIVFSMAIQSEPS 329
Cdd:PRK10133 300 YLTGTMvcffIGRFTGTWLISRFAPHKVLAAYALIAM-ALCLISAFAGGHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQ 378
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1233026567 330 KANEISALMIMGVAGGAILPLFMGIIADASNQLFSL-FVP--LFALVYIF 376
Cdd:PRK10133 379 DTKYGSSFIVMTIIGGGIVTPVMGFVSDAAGNIPTAeLIPalCFAVIFIF 428
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
35-322 |
2.17e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 42.98 E-value: 2.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 35 YVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHI-----GRKKTVLLSALItgIAMLLPFIYYSFVSVLMAFA--- 106
Cdd:cd17332 25 FYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTrsrwgRFRPWLLWGAIP--LALLFVLLFTTPDGSGTGKLiya 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 107 -----LLGIGNTILQV---SLNPLLLDvvSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLWGN----------WHLIF 168
Cdd:cd17332 103 lityiLLDLLYTLVNIpytALIPELTD--DPEERTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGgnasrgyfltALIIG 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 169 LVYAVTTGISWLWLVGTPIAEHKENHGSHVSNQIWGLLKNTKLILaFSVILLIVGFEIGLMTAVPKYLLERCNMPIEQGG 248
Cdd:cd17332 181 IIGIILLLICFFGTRERVVPPEEEKSKLPLLKSLKALLKNRPFLI-LLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELV 259
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1233026567 249 LGCSLYFSARMIGTFVGSILLARYSSRRFLVVNMIAALFVFTIFMISSDGMIILISLFGV--GLFCANVFPIVFSM 322
Cdd:cd17332 260 LLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVlaGIGYGGANLLPWAM 335
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
65-328 |
2.32e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.95 E-value: 2.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 65 TGLLMGHIGRKKTVLLSALITGIAMLLPFIYYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKA 144
Cdd:cd17503 51 SGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVIL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 145 ISSTLGPVIAGVAAGLWgNWHLIFLVYAVTTGISwlwLVGTPIAEhkenhgshvsnqiWGLLKNTKLILAFSVILLIVGF 224
Cdd:cd17503 131 LAPAIGPTLGGWLTDNL-SWRWIFYINLPIGILA---LLLAPLLD-------------LRLFKDRNFTLGLLLSFLLGLG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 225 EIGLMTAVPKYLLERCNMPIEQGGLGCSLYFSARMIGTFVGSILLARYSSRRFLVVNMI---AALFVFTIFMISSDGMII 301
Cdd:cd17503 194 LFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLllaLGTLLLAFLTPDTSLWLI 273
|
250 260
....*....|....*....|....*..
gi 1233026567 302 LISLFGVGLFCANVFPIVFSMAIQSEP 328
Cdd:cd17503 274 ILPLFIRGLGMGLVFMPLNTLALNSLP 300
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
3-178 |
4.65e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 41.84 E-value: 4.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 3 ICVENKSVRKLLPVLFAFFvMGFVDVVGISTSYVK-----------NDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGH 71
Cdd:cd17313 229 LKIMPRSLLRLLLVIFFWW-IAFFPFELFFTDYMGeevyhgtsaasSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKK 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 72 IGRKKTVLLSALITGIAMLLPFIYYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGqfIKAISSTLGP 151
Cdd:cd17313 308 IGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRGQGTDTG--LLNLAISLAQ 385
|
170 180 190
....*....|....*....|....*....|
gi 1233026567 152 VIAGVAAGLW---GNWHLIFLVYAVTTGIS 178
Cdd:cd17313 386 ILVSLLAGPIidvKGYGTVFPVAAVASFLS 415
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
16-183 |
6.68e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 41.37 E-value: 6.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 16 VLFAFFVMGFVDVVGIStsYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLLPFIY 95
Cdd:cd17370 207 LAVALFALGNFSFAFLI--LRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALG 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 96 YSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVaagLWGNWHL--IFLVYAV 173
Cdd:cd17370 285 SSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGY---LWDLISPsaAFLFSAV 361
|
170
....*....|
gi 1233026567 174 TTGISWLWLV 183
Cdd:cd17370 362 LALIALLLLL 371
|
|
| MFS_MFSD4 |
cd17395 |
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily ... |
81-355 |
1.08e-03 |
|
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily domain-containing protein 4 (MFSD4) subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The MFSD4 subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340953 [Multi-domain] Cd Length: 367 Bit Score: 40.59 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 81 SALITGIAMLLPFIYYSFVSVLMaFALLGIGNTILQVSLNPLLLDVVsKDKVTSMLTLGQFIKAISSTLGPVIAGVAAgL 160
Cdd:cd17395 69 SLLIALVLAVIPFCKDVKVLASV-MAIAGLAMGCLDTGANMQIVRMW-QKDSAPFLQVLHFSFGFGAFLAPLIADPFL-S 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 161 WGNWhlIFLVYAVTTGISWLWLVGTPIAEHKENHGSHVSNQIWGLLKNTKLILAFSVILLIVGFEIGLMTAVPKYLLERC 240
Cdd:cd17395 146 YAYW--IMALINLPVPMAVLMLLSKERLLTCCSQRRRKNLRRAPYSFFAIHITGALFLFMYVGLEGAYGAFVYSYAVEKP 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 241 NMPIEQGGLGCSLYFSARMIGTFVGSILLARYSSRRFLVVNMIAALFVFTIFMISSDGMIIL-ISLFGVGLFCANVFPIV 319
Cdd:cd17395 224 GVGHKVAAYLPSLFWGTFTLGRLLSIPISSRMKPATMVVLNVVGVVVTSLVLLLFSKSVVFLwIGTASLGLFLASTFPSM 303
|
250 260 270
....*....|....*....|....*....|....*.
gi 1233026567 320 FSMAIQSEPSKANEISALMIMGVAGGAILPLFMGII 355
Cdd:cd17395 304 LSYTEDSLQYTGCSTTVLVTGAGLGEMVLPMLVGSI 339
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
11-182 |
1.83e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.91 E-value: 1.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 11 RKLLPVLFAFFVMGFVD--VVGISTSYVKNDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIA 88
Cdd:cd06173 208 PLLRLLLLALALFALLGgaLTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 89 MLLPFIYYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLWGnWHLIF 168
Cdd:cd06173 288 LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALG-LSAVF 366
|
170
....*....|....
gi 1233026567 169 LVYAVTTGISWLWL 182
Cdd:cd06173 367 LLAGALLLLAALLL 380
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
10-180 |
3.67e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.10 E-value: 3.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 10 VRKLLPVLFAFFVMGFVDVVGISTS--YVKNDFGLNDTLANLLPMMVFLWFAVCSLP-TGLLMGHIGRKKTVLLSALITG 86
Cdd:cd17330 173 LPPLRRLLLVYFLIALAFAGLESVFslFLKDRFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAI 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 87 IAMLLPFIYYSFVSVLMAFALLGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLWGN--- 163
Cdd:cd17330 253 IGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPgvp 332
|
170
....*....|....*..
gi 1233026567 164 WHLIFLVYAVTTGISWL 180
Cdd:cd17330 333 FLLAAGLLLIALFLLSL 349
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
40-156 |
5.81e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 38.33 E-value: 5.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 40 FGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIA-MLLPFIYYSFVSVLMAFALLGIGNTILQVS 118
Cdd:cd17504 212 FGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGlLLLALLHSSLWALVVALLLIGIGLGLAFAS 291
|
90 100 110
....*....|....*....|....*....|....*...
gi 1233026567 119 LNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGV 156
Cdd:cd17504 292 LPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGA 329
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
215-358 |
6.36e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.17 E-value: 6.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 215 FSVILLIVGFEIGLMTAVPKYLLERCNMPIEQGGLGCSLYFSARMIGTFVGSILLARYSSRRFLVVNMIAALFVFTIFMI 294
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1233026567 295 SSDGMIILISLFGVGLFCANVFPIVFSMAIQSEPSKANE--ISALMIMGVAGGAILPLFMGIIADA 358
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGraLGLVSAGFGLGAALGPLLGGLLASL 147
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
71-305 |
7.59e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 37.91 E-value: 7.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 71 HIGRKKTVLLSALITGIAMLL-PFIYYSFVSVLMAFALLGIGNTIL-QV-SLNPLLLDVVSKDKVTSMLTLGQFIKAISS 147
Cdd:cd17471 59 GGDRKPLILLALLAGALGYLLfAFLRNYWVLLLVGVVLLSLGAAAFpQLfALAREYADRSSGRDATLFNSVLRAAFSLAW 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 148 TLGPVIAGVAAGLWGnWHLIFLVYAVTTGISWLWLVGTPIAEHKENHGSHVSNQIWGLLKNTKLILAFSVILLIVGFEIG 227
Cdd:cd17471 139 VIGPPLAFLLLDVLG-FTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSM 217
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1233026567 228 LMTAVPKYLLERCNMPIEQGGLGCSLYFSARMIGTFVGSILLARYSSRRFLVVNMIAALfVFTIFMISSDGMIILISL 305
Cdd:cd17471 218 YIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGV-LFYLGLALATSLWQLIAL 294
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
38-363 |
8.19e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 37.94 E-value: 8.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 38 NDFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLLPFIYYSFVSVLMAFALLGIGNTILQV 117
Cdd:cd17504 24 REFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 118 SLNpLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGVAAGLWGnWHLIFLVYAVTTGISWLWLVGTPIaehkenhgSH 197
Cdd:cd17504 104 AFA-LVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLG-WRWIFWTAAPVAVLLAALVPLIDL--------RL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 198 VSNQIWGLLKNTKLILAFSVILLIVGFEIGLMTAVPKYLLercnMPIEQGGLGCSLYFSARMIGTFVGSILLARYSSRRF 277
Cdd:cd17504 174 LRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFG----LGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 278 LVVNMIAAL--FVFTIFMISSDGMIILISLF---GVGLFCANVFPIVFSMAIQSEPSKANEISALMImgVAGGAILPLFM 352
Cdd:cd17504 250 LLIGLVISAvgLLLLALLHSSLWALVVALLLigiGLGLAFASLPNIVVESVPPDRTGIATGMNTVLR--TIGSAIGPAIA 327
|
330
....*....|.
gi 1233026567 353 GIIADASNQLF 363
Cdd:cd17504 328 GAILTTYTVSI 338
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
7-180 |
8.84e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 37.97 E-value: 8.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 7 NKSVRKLLPVLFAFFVMGFVDVVGISTS--------YVKNDFGLNDTLANLLPMMV-FLWFAVCSLPTGLLMGHIGRKKT 77
Cdd:cd17331 197 LKEILRLLRLPGVAFLLLVKLLSGLPIGmfqsmfslVAMDFFGLTPEENGYLMSYAgVLGMVVQGLLVGPLTKRFGERSL 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 78 VLLSALITGIAMLLpFIYYSFVSVLMAFAL-LGIGNTILQVSLNPLLLDVVSKDKVTSMLTLGQFIKAISSTLGPVIAGV 156
Cdd:cd17331 277 LKLSVALLAIGYLL-LAFVTTVWQLLVLLLpLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGA 355
|
170 180
....*....|....*....|....*..
gi 1233026567 157 ---AAGLWGNWHLIFLVYAVTTGISWL 180
Cdd:cd17331 356 llqAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
39-382 |
8.95e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.05 E-value: 8.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 39 DFGLNDTLANLLPMMVFLWFAVCSLPTGLLMGHIGRKKTVLLSALITGIAMLLPFIYYSFVSVLMAFALLGIGNTILQVS 118
Cdd:cd17371 28 EFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 119 LNPLLLDVVSKDK-------VTSMLTLGQFIKAISSTLgpvIAGVAAGLWGnWHLIFLVYAVTTGISWL---WLVGTPIA 188
Cdd:cd17371 108 GAALMAEYVPARHrgkalgyVQSGWAVGWLLATLLAAL---LFPLLPPEIA-WRVLFLLGALPALLVLFirrFVKEPPQW 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 189 EHKENHGSHV--SNQIWGLLKNTKLILAFSVILLIVGFEIG---LMTAVPKYLLERCNMPIEQGGLGCSLYFSARMIGTF 263
Cdd:cd17371 184 QAARAARRHFadRPSLRELFSPPLLRTTLLASLLATGALGGyygITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1233026567 264 VGSILLARYSSRR-FLVVNMIAALFVFTIFMISSDGMIILISLFGVGLFCANVFPIVFSMAIQSEPS--KANEISALMIM 340
Cdd:cd17371 264 AGGFLADRIGRRNnFALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTavRATAQGFCYNV 343
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1233026567 341 GVAGGAILPLFMGIIADASNqlFSLFVPLFALVYIFCVSLKM 382
Cdd:cd17371 344 GRIIGALFPFLVGFLATSGS--LGTAIAVFAAVYYIAGLVLA 383
|
|
| |
