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Conserved domains on  [gi|1232993989|gb|OZB89948.1|]
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MarR family transcriptional regulator [Microbacterium sp. 14-71-5]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-140 2.65e-31

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 109.29  E-value: 2.65e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232993989   2 DTPRRPERTGFLLSQLGSFAAARFAELVKPAGLTPATAGALRILARNPGLSQRALADRLGAVPSRVVVLVDALENAGLVS 81
Cdd:COG1846     4 EPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1232993989  82 RTRDPDDRRHHRLDLTDAGRAALQGLRAAAEQQNADILGPLDPGEREAFAALISRLASA 140
Cdd:COG1846    84 REPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-140 2.65e-31

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 109.29  E-value: 2.65e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232993989   2 DTPRRPERTGFLLSQLGSFAAARFAELVKPAGLTPATAGALRILARNPGLSQRALADRLGAVPSRVVVLVDALENAGLVS 81
Cdd:COG1846     4 EPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1232993989  82 RTRDPDDRRHHRLDLTDAGRAALQGLRAAAEQQNADILGPLDPGEREAFAALISRLASA 140
Cdd:COG1846    84 REPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
27-127 1.17e-21

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 83.41  E-value: 1.17e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232993989   27 ELVKPAGLTPATAGALRILARNPGLSQRALADRLGAVPSRVVVLVDALENAGLVSRTRDPDDRRHHRLDLTDAGRAALQG 106
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|.
gi 1232993989  107 LRAAAEQQNADILGPLDPGER 127
Cdd:smart00347  81 LLEARSETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 33-90 1.69e-12

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 58.75  E-value: 1.69e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1232993989  33 GLTPATAGALRILARNPGLSQRALADRLGAVPSRVVVLVDALENAGLVSRTRDPDDRR 90
Cdd:pfam12802   2 GLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 49-137 4.94e-07

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 46.54  E-value: 4.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232993989  49 PGLSQRALADRLG-AVPSRVVVLvDALENAGLVSRTRDPDDRRHHRLDLTDAGRAALQGLRAAAEQQNADILGPLDPGER 127
Cdd:PRK03573   45 PEQSQIQLAKAIGiEQPSLVRTL-DQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVEAVINKTRAEILHGISAEEI 123

                          90
                  ....*....|
gi 1232993989 128 EAFAALISRL 137
Cdd:PRK03573  124 EQLITLIAKL 133
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-140 2.65e-31

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 109.29  E-value: 2.65e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232993989   2 DTPRRPERTGFLLSQLGSFAAARFAELVKPAGLTPATAGALRILARNPGLSQRALADRLGAVPSRVVVLVDALENAGLVS 81
Cdd:COG1846     4 EPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1232993989  82 RTRDPDDRRHHRLDLTDAGRAALQGLRAAAEQQNADILGPLDPGEREAFAALISRLASA 140
Cdd:COG1846    84 REPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
27-127 1.17e-21

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 83.41  E-value: 1.17e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232993989   27 ELVKPAGLTPATAGALRILARNPGLSQRALADRLGAVPSRVVVLVDALENAGLVSRTRDPDDRRHHRLDLTDAGRAALQG 106
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|.
gi 1232993989  107 LRAAAEQQNADILGPLDPGER 127
Cdd:smart00347  81 LLEARSETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 33-90 1.69e-12

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 58.75  E-value: 1.69e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1232993989  33 GLTPATAGALRILARNPGLSQRALADRLGAVPSRVVVLVDALENAGLVSRTRDPDDRR 90
Cdd:pfam12802   2 GLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 34-92 7.18e-11

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 54.48  E-value: 7.18e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1232993989  34 LTPATAGALRILARNPGLSQRALADRLGAVPSRVVVLVDALENAGLVSRTRDPDDRRHH 92
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 49-137 4.94e-07

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 46.54  E-value: 4.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232993989  49 PGLSQRALADRLG-AVPSRVVVLvDALENAGLVSRTRDPDDRRHHRLDLTDAGRAALQGLRAAAEQQNADILGPLDPGER 127
Cdd:PRK03573   45 PEQSQIQLAKAIGiEQPSLVRTL-DQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVEAVINKTRAEILHGISAEEI 123

                          90
                  ....*....|
gi 1232993989 128 EAFAALISRL 137
Cdd:PRK03573  124 EQLITLIAKL 133
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
42-80 2.55e-06

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 42.04  E-value: 2.55e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1232993989  42 LRILARNPGLSQRALADRLGAVPSRVVVLVDALENAGLV 80
Cdd:pfam13412   7 LNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_27 pfam13463
Winged helix DNA-binding domain;
34-100 2.87e-06

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 42.66  E-value: 2.87e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1232993989  34 LTPATAGALRIL-ARNPGLSQRALADRLGAVPSRVVVLVDALENAGLVSRTRDPDDRRHHRLDLTDAG 100
Cdd:pfam13463   1 LTRLEALILHNIgHRGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
GbsR COG1510
DNA-binding transcriptional regulator GbsR, MarR family [Transcription];
1-92 1.52e-05

DNA-binding transcriptional regulator GbsR, MarR family [Transcription];


Pssm-ID: 441119  Cd Length: 164  Bit Score: 42.61  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232993989   1 MDTPRRPERTGFLLsqlgsfaaaRFAELVKPAGLTPATAgalRILA----RNPGLSQRALADRLGAVPSRVVVLVDALEN 76
Cdd:COG1510     1 MSEKLEEAKERFIE---------AFGEMGERWGLPRSAG---RIYAllylSDEPLTADELAEELGVSKSSVSTALRELED 68

                          90
                  ....*....|....*.
gi 1232993989  77 AGLVSRTRDPDDRRHH 92
Cdd:COG1510    69 WGLVRRVRKPGDRKDY 84
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
40-109 2.52e-05

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 41.01  E-value: 2.52e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1232993989  40 GALR---ILARNPGLSQRALADRLgavpsrvvvlvDALENAGLVSRTRDPDDRRHHRLDLTDAGRAALQGLRA 109
Cdd:COG1733    34 GPRRfgeLRRSLPGISQKMLTQRL-----------RELEEDGLVERTVYPEVPPRVEYSLTEKGRSLLPVLDA 95
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
42-92 8.84e-05

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 40.63  E-value: 8.84e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1232993989  42 LRILARNPGLSQRALADRLGAVPSRVVVLVDALENAGLVSRTRDPDDRRHH 92
Cdd:COG3398   103 LLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYY 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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