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Conserved domains on  [gi|1232570517|gb|OYY12199.1|]
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hypothetical protein B7Y66_00125 [Sphingobacteriia bacterium 35-36-14]

Protein Classification

aminopeptidase P family protein( domain architecture ID 10659798)

aminopeptidase family protein P (peptidase M24) cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

CATH:  3.40.350.10|3.90.230.10
EC:  3.4.11.-
Gene Ontology:  GO:0004177|GO:0016020|GO:0070006|GO:0046872|GO:0006508
MEROPS:  M24
PubMed:  30066404|9434107|12475202

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 218-448 1.37e-106

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


:

Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 316.44  E-value: 1.37e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 218 IAILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYAFKKNGSEyPGYPSINGAAENACVLHYVTNLKLMKNGDLLLSD 297
Cdd:cd01087     1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGAR-LAYSYIVAAGSNAAILHYVHNDQPLKDGDLVLID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 298 CAAEYHGYTADVTRTVPVNGKFSPEQKIIYELVLAAQDSAIAVCKPGMPYSGSDATARRVINRGLIALGIAANDMEA--- 374
Cdd:cd01087    80 AGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDVDEive 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 375 ----RRYFPHGTSHHLGLDVHDLG-----IRGNMPFEPGMYLTVEPGIYIPPGSKCDPKWW-SIGVRIEDDILITKEGNR 444
Cdd:cd01087   160 sgayAKFFPHGLGHYLGLDVHDVGgylryLRRARPLEPGMVITIEPGIYFIPDLLDVPEYFrGGGIRIEDDVLVTEDGPE 239


                  ....
gi 1232570517 445 NLSA 448
Cdd:cd01087   240 NLTR 243
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 32-148 4.80e-32

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


:

Pssm-ID: 198079  Cd Length: 135  Bit Score: 118.88  E-value: 4.80e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517   32 LSPEFHAGRRAAFKEKMPAKSVGIFFASQVRLRNDDVDYQYAQSKNFYYFTGLEEPNSLLLLFKEPttilgKTGTEFIFV 111
Cdd:smart01011   1 IPAAEYAARRRRLAAKLFPGSVAVLPAGPEKVRSNDTDYPFRQDSDFYYLTGFDEPDAVLVLDPSG-----GGGKSTLFV 75

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1232570517  112 QNRDPQREMWNGKILGIEGVTNRYKFSNVFLNKEFTA 148
Cdd:smart01011  76 PPRDPEDELWDGPRLGLEEAKEKFGVDEVYPIDELDA 112
 
Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 218-448 1.37e-106

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 316.44  E-value: 1.37e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 218 IAILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYAFKKNGSEyPGYPSINGAAENACVLHYVTNLKLMKNGDLLLSD 297
Cdd:cd01087     1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGAR-LAYSYIVAAGSNAAILHYVHNDQPLKDGDLVLID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 298 CAAEYHGYTADVTRTVPVNGKFSPEQKIIYELVLAAQDSAIAVCKPGMPYSGSDATARRVINRGLIALGIAANDMEA--- 374
Cdd:cd01087    80 AGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDVDEive 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 375 ----RRYFPHGTSHHLGLDVHDLG-----IRGNMPFEPGMYLTVEPGIYIPPGSKCDPKWW-SIGVRIEDDILITKEGNR 444
Cdd:cd01087   160 sgayAKFFPHGLGHYLGLDVHDVGgylryLRRARPLEPGMVITIEPGIYFIPDLLDVPEYFrGGGIRIEDDVLVTEDGPE 239


                  ....
gi 1232570517 445 NLSA 448
Cdd:cd01087   240 NLTR 243
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 32-464 3.91e-104

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 317.05  E-value: 3.91e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517  32 LSPEFHAGRRAAFKEKMPAKSVGIFFASQVRLRNDDVDYQYAQSKNFYYFTGLEEPNSLLLLFKEPTTilgkTGTEFIFV 111
Cdd:PRK10879    1 MTQQEFQRRRQALLAKMQPGSAALIFAAPEATRSADSEYPYRQNSDFWYFTGFNEPEAVLVLIKSDDT----HNHSVLFN 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 112 QNRDPQREMWNGKILGIEGVTNRYKFSNVFLNKEFTANTFNL-NDYDSVLTAfrsedifQTYPRTRDELSRMAgvVDSLI 190
Cdd:PRK10879   77 RVRDLTAEIWFGRRLGQDAAPEKLGVDRALPFSEINQQLYQLlNGLDVVYHA-------QGEYAYADEIVFSA--LEKLR 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 191 KQYKKPIAARTTAQ----IMTALRGIKQPEEIAILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYAFKKNGSEYPGY 266
Cdd:PRK10879  148 KGSRQNLTAPATLTdwrpWVHEMRLFKSPEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEIHHEFNRHGARYPSY 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 267 PSINGAAENACVLHYVTNLKLMKNGDLLLSDCAAEYHGYTADVTRTVPVNGKFSPEQKIIYELVLAAQDSAIAVCKPGMP 346
Cdd:PRK10879  228 NTIVGSGENGCILHYTENESEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTPAQREIYDIVLESLETSLRLYRPGTS 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 347 YSGSDATARRVINRGLIALGIAANDMEA-------RRYFPHGTSHHLGLDVHDLGIRG---NMPFEPGMYLTVEPGIYIP 416
Cdd:PRK10879  308 IREVTGEVVRIMVSGLVKLGILKGDVDQliaenahRPFFMHGLSHWLGLDVHDVGVYGqdrSRILEPGMVLTVEPGLYIA 387

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1232570517 417 PGSKCDPKWWSIGVRIEDDILITKEGNRNLSAGAPRTVAEIEKL-AKAK 464
Cdd:PRK10879  388 PDADVPEQYRGIGIRIEDDIVITETGNENLTASVVKKPDEIEALmAAAR 436
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
203-457 3.91e-94

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 286.72  E-value: 3.91e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 203 AQIMTALRGIKQPEEIAILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYAFKKNGSEYPGYPSINGAAENACVLHYV 282
Cdd:COG0006    64 SDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRRGAEGPSFDTIVASGENAAIPHYT 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 283 TNLKLMKNGDLLLSDCAAEYHGYTADVTRTVPVnGKFSPEQKIIYELVLAAQDSAIAVCKPGMPYSGSDATARRVINRGL 362
Cdd:COG0006   144 PTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAV-GEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAG 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 363 IalgiaandmeaRRYFPHGTSHHLGLDVHD---LGIRGNMPFEPGMYLTVEPGIYIPPgskcdpkWWsiGVRIEDDILIT 439
Cdd:COG0006   223 Y-----------GEYFPHGTGHGVGLDVHEgpqISPGNDRPLEPGMVFTIEPGIYIPG-------IG--GVRIEDTVLVT 282

                         250
                  ....*....|....*...
gi 1232570517 440 KEGNRNLSAgAPRTVAEI 457
Cdd:COG0006   283 EDGAEVLTR-LPRELLEL 299
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 219-440 1.00e-73

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 230.98  E-value: 1.00e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 219 AILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYA-FKKNGSEYPGYPSINGAAENACVLHYVTNLKLMKNGDLLLSD 297
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAArLRRGGARGPAFPPIVASGPNAAIPHYIPNDRVLKPGDLVLID 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 298 CAAEY-HGYTADVTRTVpVNGKFSPEQKIIYELVLAAQDSAIAVCKPGMPYSGSDATARRVINRGlialGIAAndmearr 376
Cdd:pfam00557  81 VGAEYdGGYCSDITRTF-VVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEA----GLGE------- 148

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1232570517 377 YFPHGTSHHLGLDVHDLGI----RGNMPFEPGMYLTVEPGIYIPPGskcdpkwWSiGVRIEDDILITK 440
Cdd:pfam00557 149 YFPHGLGHGIGLEVHEGPYisrgGDDRVLEPGMVFTIEPGIYFIPG-------WG-GVRIEDTVLVTE 208
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 32-148 4.80e-32

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


Pssm-ID: 198079  Cd Length: 135  Bit Score: 118.88  E-value: 4.80e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517   32 LSPEFHAGRRAAFKEKMPAKSVGIFFASQVRLRNDDVDYQYAQSKNFYYFTGLEEPNSLLLLFKEPttilgKTGTEFIFV 111
Cdd:smart01011   1 IPAAEYAARRRRLAAKLFPGSVAVLPAGPEKVRSNDTDYPFRQDSDFYYLTGFDEPDAVLVLDPSG-----GGGKSTLFV 75

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1232570517  112 QNRDPQREMWNGKILGIEGVTNRYKFSNVFLNKEFTA 148
Cdd:smart01011  76 PPRDPEDELWDGPRLGLEEAKEKFGVDEVYPIDELDA 112
AMP_N pfam05195
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 37-146 3.90e-31

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain (pfam01321). However, little or no sequence similarity exists between the two families.


Pssm-ID: 461581 [Multi-domain]  Cd Length: 121  Bit Score: 116.07  E-value: 3.90e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517  37 HAGRRAAFKEKMPAKSVGIFFASQVRLRNDDVDYQYAQSKNFYYFTGLEEPNSLLLLFKEPttilGKTGTEFIFVQNRDP 116
Cdd:pfam05195   1 YAERRARLLAKLPPNSVAILPGAPEKYRNGDVFYPFRQDSDFYYLTGFNEPDAVLVLEGGD----IDSGKETLFVPPKDP 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 1232570517 117 QREMWNGKILGIEGVTNRYKFSNVFLNKEF 146
Cdd:pfam05195  77 EDEIWDGPRLGPEEAKELFGVDEVYPIDEL 106
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 212-411 1.22e-18

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 85.09  E-value: 1.22e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 212 IKQPEEIAILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYAFKKNGSE-----YPGYPSINGAAENACVLHYVTNLK 286
Cdd:TIGR00500   3 LKSPDEIEKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHGAKpaflgYYGFPGSVCISVNEVVIHGIPDKK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 287 LMKNGDLLLSDCAAEYHGYTADVTRTVPVnGKFSPEQKIIYELVLAAQDSAIAVCKPGMPYSG-SDATARRVINRGLIAL 365
Cdd:TIGR00500  83 VLKDGDIVNIDVGVIYDGYHGDTAKTFLV-GKISPEAEKLLECTEESLYKAIEEAKPGNRIGEiGAAIQKYAEAKGFSVV 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1232570517 366 giaandmeaRRYFPHGtshhLGLDVH-DLGI------RGNMPFEPGMYLTVEP 411
Cdd:TIGR00500 162 ---------REYCGHG----IGRKFHeEPQIpnygkkFTNVRLKEGMVFTIEP 201
 
Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 218-448 1.37e-106

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 316.44  E-value: 1.37e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 218 IAILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYAFKKNGSEyPGYPSINGAAENACVLHYVTNLKLMKNGDLLLSD 297
Cdd:cd01087     1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGAR-LAYSYIVAAGSNAAILHYVHNDQPLKDGDLVLID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 298 CAAEYHGYTADVTRTVPVNGKFSPEQKIIYELVLAAQDSAIAVCKPGMPYSGSDATARRVINRGLIALGIAANDMEA--- 374
Cdd:cd01087    80 AGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDVDEive 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 375 ----RRYFPHGTSHHLGLDVHDLG-----IRGNMPFEPGMYLTVEPGIYIPPGSKCDPKWW-SIGVRIEDDILITKEGNR 444
Cdd:cd01087   160 sgayAKFFPHGLGHYLGLDVHDVGgylryLRRARPLEPGMVITIEPGIYFIPDLLDVPEYFrGGGIRIEDDVLVTEDGPE 239


                  ....
gi 1232570517 445 NLSA 448
Cdd:cd01087   240 NLTR 243
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 32-464 3.91e-104

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 317.05  E-value: 3.91e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517  32 LSPEFHAGRRAAFKEKMPAKSVGIFFASQVRLRNDDVDYQYAQSKNFYYFTGLEEPNSLLLLFKEPTTilgkTGTEFIFV 111
Cdd:PRK10879    1 MTQQEFQRRRQALLAKMQPGSAALIFAAPEATRSADSEYPYRQNSDFWYFTGFNEPEAVLVLIKSDDT----HNHSVLFN 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 112 QNRDPQREMWNGKILGIEGVTNRYKFSNVFLNKEFTANTFNL-NDYDSVLTAfrsedifQTYPRTRDELSRMAgvVDSLI 190
Cdd:PRK10879   77 RVRDLTAEIWFGRRLGQDAAPEKLGVDRALPFSEINQQLYQLlNGLDVVYHA-------QGEYAYADEIVFSA--LEKLR 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 191 KQYKKPIAARTTAQ----IMTALRGIKQPEEIAILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYAFKKNGSEYPGY 266
Cdd:PRK10879  148 KGSRQNLTAPATLTdwrpWVHEMRLFKSPEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEIHHEFNRHGARYPSY 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 267 PSINGAAENACVLHYVTNLKLMKNGDLLLSDCAAEYHGYTADVTRTVPVNGKFSPEQKIIYELVLAAQDSAIAVCKPGMP 346
Cdd:PRK10879  228 NTIVGSGENGCILHYTENESEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTPAQREIYDIVLESLETSLRLYRPGTS 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 347 YSGSDATARRVINRGLIALGIAANDMEA-------RRYFPHGTSHHLGLDVHDLGIRG---NMPFEPGMYLTVEPGIYIP 416
Cdd:PRK10879  308 IREVTGEVVRIMVSGLVKLGILKGDVDQliaenahRPFFMHGLSHWLGLDVHDVGVYGqdrSRILEPGMVLTVEPGLYIA 387

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1232570517 417 PGSKCDPKWWSIGVRIEDDILITKEGNRNLSAGAPRTVAEIEKL-AKAK 464
Cdd:PRK10879  388 PDADVPEQYRGIGIRIEDDIVITETGNENLTASVVKKPDEIEALmAAAR 436
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
203-457 3.91e-94

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 286.72  E-value: 3.91e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 203 AQIMTALRGIKQPEEIAILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYAFKKNGSEYPGYPSINGAAENACVLHYV 282
Cdd:COG0006    64 SDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRRGAEGPSFDTIVASGENAAIPHYT 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 283 TNLKLMKNGDLLLSDCAAEYHGYTADVTRTVPVnGKFSPEQKIIYELVLAAQDSAIAVCKPGMPYSGSDATARRVINRGL 362
Cdd:COG0006   144 PTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAV-GEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAG 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 363 IalgiaandmeaRRYFPHGTSHHLGLDVHD---LGIRGNMPFEPGMYLTVEPGIYIPPgskcdpkWWsiGVRIEDDILIT 439
Cdd:COG0006   223 Y-----------GEYFPHGTGHGVGLDVHEgpqISPGNDRPLEPGMVFTIEPGIYIPG-------IG--GVRIEDTVLVT 282

                         250
                  ....*....|....*...
gi 1232570517 440 KEGNRNLSAgAPRTVAEI 457
Cdd:COG0006   283 EDGAEVLTR-LPRELLEL 299
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 219-440 1.00e-73

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 230.98  E-value: 1.00e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 219 AILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYA-FKKNGSEYPGYPSINGAAENACVLHYVTNLKLMKNGDLLLSD 297
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAArLRRGGARGPAFPPIVASGPNAAIPHYIPNDRVLKPGDLVLID 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 298 CAAEY-HGYTADVTRTVpVNGKFSPEQKIIYELVLAAQDSAIAVCKPGMPYSGSDATARRVINRGlialGIAAndmearr 376
Cdd:pfam00557  81 VGAEYdGGYCSDITRTF-VVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEA----GLGE------- 148

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1232570517 377 YFPHGTSHHLGLDVHDLGI----RGNMPFEPGMYLTVEPGIYIPPGskcdpkwWSiGVRIEDDILITK 440
Cdd:pfam00557 149 YFPHGLGHGIGLEVHEGPYisrgGDDRVLEPGMVFTIEPGIYFIPG-------WG-GVRIEDTVLVTE 208
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 218-442 9.94e-67

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 212.75  E-value: 9.94e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 218 IAILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYAFKKNGSEYPGYPSINGAAENACVLHYVTNLKLMKNGDLLLSD 297
Cdd:cd01092     1 IELLRKAARIADKAFEELLEFIKPGMTEREVAAELEYFMRKLGAEGPSFDTIVASGPNSALPHGVPSDRKIEEGDLVLID 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 298 CAAEYHGYTADVTRTVPVnGKFSPEQKIIYELVLAAQDSAIAVCKPGMPYSGSDATARRVI-NRGLialgiaandmeaRR 376
Cdd:cd01092    81 FGAIYDGYCSDITRTVAV-GEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEVDKAARDVIeEAGY------------GE 147

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1232570517 377 YFPHGTSHHLGLDVH---DLGIRGNMPFEPGMYLTVEPGIYIppgskcdPKWWsiGVRIEDDILITKEG 442
Cdd:cd01092   148 YFIHRTGHGVGLEVHeapYISPGSDDVLEEGMVFTIEPGIYI-------PGKG--GVRIEDDVLVTEDG 207
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 218-442 9.01e-51

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 171.48  E-value: 9.01e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 218 IAILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYAFKKNGSeYPGYPSINGAAENACVLHYVTNLKLMKNGDLLLSD 297
Cdd:cd01066     1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGG-YPAGPTIVGSGARTALPHYRPDDRRLQEGDLVLVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 298 CAAEYHGYTADVTRTVPVnGKFSPEQKIIYELVLAAQDSAIAVCKPGMPYSGSDATARRVINRGLialgiaandmeARRY 377
Cdd:cd01066    80 LGGVYDGYHADLTRTFVI-GEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHG-----------LGPN 147

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1232570517 378 FPHGTSHHLGLDVHDLGI---RGNMPFEPGMYLTVEPGIYIPPGskcdpkwwsIGVRIEDDILITKEG 442
Cdd:cd01066   148 FGHRTGHGIGLEIHEPPVlkaGDDTVLEPGMVFAVEPGLYLPGG---------GGVRIEDTVLVTEDG 206
PRK09795 PRK09795
aminopeptidase; Provisional
 191-454 4.27e-40

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 147.78  E-value: 4.27e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 191 KQYKKPIAARTTAQIMTALRGIKQPEEIAILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYAFKKNGSEYPGYPSIN 270
Cdd:PRK09795  106 HRWQSELNAKLVSATPDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKASFDTIV 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 271 GAAENACVLHYVTNLKLMKNGDLLLSDCAAEYHGYTADVTRTVPVNGKFSPEQK----IIYELVLAAQDSAIAVCKPGMP 346
Cdd:PRK09795  186 ASGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAEShplfNVYQIVLQAQLAAISAIRPGVR 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 347 YSGSDATARRVINRGLIAlgiaandmearRYFPHGTSHHLGLDVHD---LGIRGNMPFEPGMYLTVEPGIYIPPGSkcdp 423
Cdd:PRK09795  266 CQQVDDAARRVITEAGYG-----------DYFGHNTGHAIGIEVHEdprFSPRDTTTLQPGMLLTVEPGIYLPGQG---- 330

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1232570517 424 kwwsiGVRIEDDILITKEGNRNLSAgAPRTV 454
Cdd:PRK09795  331 -----GVRIEDVVLVTPQGAEVLYA-MPKTV 355
PRK13607 PRK13607
proline dipeptidase; Provisional
 210-446 1.06e-32

proline dipeptidase; Provisional


Pssm-ID: 237444 [Multi-domain]  Cd Length: 443  Bit Score: 128.86  E-value: 1.06e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 210 RGIKQPEEIAILEKAAAISVEGHNEVMKAVKPGMTEYQAQaiMEY--AFKKNGSEYPgYPSINGAAENACVLHYvTNLKL 287
Cdd:PRK13607  159 RAYKTDYELACMREAQKIAVAGHRAAKEAFRAGMSEFDIN--LAYltATGQRDNDVP-YGNIVALNEHAAVLHY-TKLDH 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 288 MKNGDL--LLSDCAAEYHGYTADVTRTVPvngkfSPEQKIIYELVLA---AQDSAIAVCKPGMPYSGSDATARRVINRGL 362
Cdd:PRK13607  235 QAPAEMrsFLIDAGAEYNGYAADITRTYA-----AKEDNDFAALIKDvnkEQLALIATMKPGVSYVDLHIQMHQRIAKLL 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 363 IALGIAaNDMEA---------RRYFPHGTSHHLGLDVHDLGirGNM--------------PF-------EPGMYLTVEPG 412
Cdd:PRK13607  310 RKFQIV-TGLSEeamveqgitSPFFPHGLGHPLGLQVHDVA--GFMqddrgthlaapekhPYlrctrvlEPGMVLTIEPG 386

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1232570517 413 IYI-----------PPGSKCDpkWWSI-------GVRIEDDILITKEGNRNL 446
Cdd:PRK13607  387 LYFidsllaplregPFSKHFN--WQKIdalkpfgGIRIEDNVVVHENGVENM 436
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 32-148 4.80e-32

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


Pssm-ID: 198079  Cd Length: 135  Bit Score: 118.88  E-value: 4.80e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517   32 LSPEFHAGRRAAFKEKMPAKSVGIFFASQVRLRNDDVDYQYAQSKNFYYFTGLEEPNSLLLLFKEPttilgKTGTEFIFV 111
Cdd:smart01011   1 IPAAEYAARRRRLAAKLFPGSVAVLPAGPEKVRSNDTDYPFRQDSDFYYLTGFDEPDAVLVLDPSG-----GGGKSTLFV 75

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1232570517  112 QNRDPQREMWNGKILGIEGVTNRYKFSNVFLNKEFTA 148
Cdd:smart01011  76 PPRDPEDELWDGPRLGLEEAKEKFGVDEVYPIDELDA 112
AMP_N pfam05195
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 37-146 3.90e-31

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain (pfam01321). However, little or no sequence similarity exists between the two families.


Pssm-ID: 461581 [Multi-domain]  Cd Length: 121  Bit Score: 116.07  E-value: 3.90e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517  37 HAGRRAAFKEKMPAKSVGIFFASQVRLRNDDVDYQYAQSKNFYYFTGLEEPNSLLLLFKEPttilGKTGTEFIFVQNRDP 116
Cdd:pfam05195   1 YAERRARLLAKLPPNSVAILPGAPEKYRNGDVFYPFRQDSDFYYLTGFNEPDAVLVLEGGD----IDSGKETLFVPPKDP 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 1232570517 117 QREMWNGKILGIEGVTNRYKFSNVFLNKEF 146
Cdd:pfam05195  77 EDEIWDGPRLGPEEAKELFGVDEVYPIDEL 106
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 244-440 6.23e-26

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 104.95  E-value: 6.23e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 244 TEYQAQAIMEYaFKKNGSEYPG--YPSINGAAENACVLHY----VTNLKLMKNGdLLLSDCAAEYHGYTADVTRTVPVnG 317
Cdd:cd01085    31 TELSAADKLEE-FRRQQKGYVGlsFDTISGFGPNGAIVHYspteESNRKISPDG-LYLIDSGGQYLDGTTDITRTVHL-G 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 318 KFSPEQKIIYELVLAAQ-DSAIAVCKPGMPYSGSDATARRVI-NRGLialgiaanDmearryFPHGTSHHLG--LDVHDL 393
Cdd:cd01085   108 EPTAEQKRDYTLVLKGHiALARAKFPKGTTGSQLDALARQPLwKAGL--------D------YGHGTGHGVGsfLNVHEG 173

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1232570517 394 GIR-----GNMPFEPGMYLTVEPGIYIpPGskcdpKWwsiGVRIEDDILITK 440
Cdd:cd01085   174 PQSispapNNVPLKAGMILSNEPGYYK-EG-----KY---GIRIENLVLVVE 216
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 212-411 1.22e-18

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 85.09  E-value: 1.22e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 212 IKQPEEIAILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYAFKKNGSE-----YPGYPSINGAAENACVLHYVTNLK 286
Cdd:TIGR00500   3 LKSPDEIEKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHGAKpaflgYYGFPGSVCISVNEVVIHGIPDKK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 287 LMKNGDLLLSDCAAEYHGYTADVTRTVPVnGKFSPEQKIIYELVLAAQDSAIAVCKPGMPYSG-SDATARRVINRGLIAL 365
Cdd:TIGR00500  83 VLKDGDIVNIDVGVIYDGYHGDTAKTFLV-GKISPEAEKLLECTEESLYKAIEEAKPGNRIGEiGAAIQKYAEAKGFSVV 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1232570517 366 giaandmeaRRYFPHGtshhLGLDVH-DLGI------RGNMPFEPGMYLTVEP 411
Cdd:TIGR00500 162 ---------REYCGHG----IGRKFHeEPQIpnygkkFTNVRLKEGMVFTIEP 201
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
212-413 1.95e-18

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 84.67  E-value: 1.95e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 212 IKQPEEIAILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYAFKKNGSE-----YPGYP-----SINGAaenacVLHY 281
Cdd:COG0024     3 IKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDHGAIpaflgYYGFPksictSVNEV-----VVHG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 282 VTNLKLMKNGDLLLSDCAAEYHGYTADVTRTVPVnGKFSPEQKiiyELVLAAQDS---AIAVCKPGMPYS------GSDA 352
Cdd:COG0024    78 IPSDRVLKDGDIVNIDVGAILDGYHGDSARTFVV-GEVSPEAR---RLVEVTEEAlyaGIAAAKPGNRLGdighaiQSYA 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1232570517 353 TARR-VINRGLIALGIaandmearryfphGTSHHLGLDVHDLGIRG-NMPFEPGMYLTVEPGI 413
Cdd:COG0024   154 ESNGySVVREFVGHGI-------------GREMHEEPQVPNYGRPGrGPRLKPGMVLAIEPMI 203
PRK05716 PRK05716
methionine aminopeptidase; Validated
 212-413 9.55e-17

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 79.79  E-value: 9.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 212 IKQPEEIAILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYAFKKNGSE-----YPGYP-----SINgaaENACvlHY 281
Cdd:PRK05716    5 IKTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRDQGAIpaplgYHGFPksictSVN---EVVC--HG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 282 VTNLKLMKNGDLLLSDCAAEYHGYTADVTRTVPVnGKFSPEQKiiyELVLAAQDS---AIAVCKPGMPYSGSDATARRVI 358
Cdd:PRK05716   80 IPSDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGV-GEISPEDK---RLCEVTKEAlylGIAAVKPGARLGDIGHAIQKYA 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1232570517 359 nrglialgiaandmEARRYFP------HG--TSHHLGLDV-HDLGIRGNMPFEPGMYLTVEPGI 413
Cdd:PRK05716  156 --------------EAEGFSVvreycgHGigRKFHEEPQIpHYGAPGDGPVLKEGMVFTIEPMI 205
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 218-442 1.88e-16

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 78.69  E-value: 1.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 218 IAILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYAFKKNGS-----EYPGYPSINGAAENACVLHYVTNLKLMKNGD 292
Cdd:cd01086     1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAypaplGYYGFPKSICTSVNEVVCHGIPDDRVLKDGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 293 LLLSDCAAEYHGYTADVTRTVPVnGKFSPEQKIIYELVLAAQDSAIAVCKPGMPYSG-SDATARRVINRGLIALgiaand 371
Cdd:cd01086    81 IVNIDVGVELDGYHGDSARTFIV-GEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDiGHAIEKYAEKNGYSVV------ 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 372 meaRRYfphgTSHHLGLDVHD------LGIRG-NMPFEPGMYLTVEPGIYIppGS---KCDPKWWSIGVR-------IED 434
Cdd:cd01086   154 ---REF----GGHGIGRKFHEepqipnYGRPGtGPKLKPGMVFTIEPMINL--GTyevVTLPDGWTVVTKdgslsaqFEH 224


                  ....*...
gi 1232570517 435 DILITKEG 442
Cdd:cd01086   225 TVLITEDG 232
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 212-443 4.88e-14

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 71.79  E-value: 4.88e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 212 IKQPEEIAILEKAAAISVEGHNEVMKAVKPGMTEYQ----AQAIMEY-----AFKKngseYPGYPSINGAAENACVLHYV 282
Cdd:PRK12896   10 IKSPRELEKMRKIGRIVATALKEMGKAVEPGMTTKEldriAEKRLEEhgaipSPEG----YYGFPGSTCISVNEEVAHGI 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 283 TNLKLMKNGDLLLSDCAAEYHGYTADVTRTVPVnGKFSPEqkiIYELVLAAQDS---AIAVCKPGMPYSGsdatarrvin 359
Cdd:PRK12896   86 PGPRVIKDGDLVNIDVSAYLDGYHGDTGITFAV-GPVSEE---AEKLCRVAEEAlwaGIKQVKAGRPLND---------- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 360 rglIALGIAAndmEARRyfpHG-------TSHHLGLDVHdlgirgNMP--------------FEPGMYLTVEPgiYIPPG 418
Cdd:PRK12896  152 ---IGRAIED---FAKK---NGysvvrdlTGHGVGRSLH------EEPsviltytdplpnrlLRPGMTLAVEP--FLNLG 214

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1232570517 419 SK------------CDPKWWSigVRIEDDILITKEGN 443
Cdd:PRK12896  215 AKdaetlddgwtvvTPDKSLS--AQFEHTVVVTRDGP 249
PRK15173 PRK15173
peptidase; Provisional
 202-447 2.98e-11

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 64.35  E-value: 2.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 202 TAQIMTALRGIKQPEEIAILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYA-FKKNGSEYPGYPSINGAAENACVLh 280
Cdd:PRK15173   85 SSSIFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAvMSKSETHFSRFHLISVGADFSPKL- 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 281 YVTNLKLMkNGDLLLSDCAAEYHGYTADVTRTVPVnGKFSPEQKIIYELVLAAQDSAIAVCKPGMPYSGS-DATARRVIN 359
Cdd:PRK15173  164 IPSNTKAC-SGDLIKFDCGVDVDGYGADIARTFVV-GEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVfDSTMEVIKK 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 360 RGLIALGiaandmeaRRYFPHGTSHHLGLDVHD-LGIRGNMPFEPGMYLTVEPGIYippgskcdpkWWSIG-VRIEDDIL 437
Cdd:PRK15173  242 SGLPNYN--------RGHLGHGNGVFLGLEESPfVSTHATESFTSGMVLSLETPYY----------GYNLGsIMIEDMIL 303

                         250
                  ....*....|
gi 1232570517 438 ITKEGNRNLS 447
Cdd:PRK15173  304 INKEGIEFLS 313
PRK14575 PRK14575
putative peptidase; Provisional
 202-447 6.73e-11

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 63.96  E-value: 6.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 202 TAQIMTALRGIKQPEEIAILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYA-FKKNGSEYPGYPSINGAAENACVLh 280
Cdd:PRK14575  168 SSSIFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAvMSKSETHFSRFHLISVGADFSPKL- 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 281 YVTNLKLMkNGDLLLSDCAAEYHGYTADVTRTVPVnGKFSPEQKIIYELVLAAQDSAIAVCKPGMPYSGS-DATARRVIN 359
Cdd:PRK14575  247 IPSNTKAC-SGDLIKFDCGVDVDGYGADIARTFVV-GEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVfDSTMEVIKK 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 360 RGLIALGiaandmeaRRYFPHGTSHHLGLDVHD-LGIRGNMPFEPGMYLTVEPGIYippgskcdpkWWSIG-VRIEDDIL 437
Cdd:PRK14575  325 SGLPNYN--------RGHLGHGNGVFLGLEESPfVSTHATESFTSGMVLSLETPYY----------GYNLGsIMIEDMIL 386

                         250
                  ....*....|
gi 1232570517 438 ITKEGNRNLS 447
Cdd:PRK14575  387 INKEGIEFLS 396
PRK12897 PRK12897
type I methionyl aminopeptidase;
212-442 2.02e-10

type I methionyl aminopeptidase;


Pssm-ID: 171806  Cd Length: 248  Bit Score: 61.20  E-value: 2.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 212 IKQPEEIAILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYAFKKNGSE-----YPGYPSINGAAENACVLHYVTNLK 286
Cdd:PRK12897    4 IKTKNEIDLMHESGKLLASCHREIAKIMKPGITTKEINTFVEAYLEKHGATseqkgYNGYPYAICASVNDEMCHAFPADV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 287 LMKNGDLLLSDCAAEYHGYTADVTRTVPVnGKFSPEQKiiyELVLAAQDSAiavckpgmpYSGSDataRRVINRGLIALG 366
Cdd:PRK12897   84 PLTEGDIVTIDMVVNLNGGLSDSAWTYRV-GKVSDEAE---KLLLVAENAL---------YKGID---QAVIGNRVGDIG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 367 IAANDMEARRYFPHG---TSHHLGLDVHD------LGIRGNMP-FEPGMYLTVEPGIYIPPG-SKCDPKWWS-------I 428
Cdd:PRK12897  148 YAIESYVANEGFSVArdfTGHGIGKEIHEepaifhFGKQGQGPeLQEGMVITIEPIVNVGMRySKVDLNGWTartmdgkL 227

                         250
                  ....*....|....
gi 1232570517 429 GVRIEDDILITKEG 442
Cdd:PRK12897  228 SAQYEHTIAITKDG 241
PLN03158 PLN03158
methionine aminopeptidase; Provisional
 212-451 1.67e-06

methionine aminopeptidase; Provisional


Pssm-ID: 215607 [Multi-domain]  Cd Length: 396  Bit Score: 50.22  E-value: 1.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 212 IKQPEEIAILEKAAAISVEGHNEVMKAVKPGMTEYQAQAIMEYAFKKNGseypGYPS-IN--------GAAENACVLHYV 282
Cdd:PLN03158  137 IKTPEQIQRMRETCRIAREVLDAAARAIKPGVTTDEIDRVVHEATIAAG----GYPSpLNyhffpkscCTSVNEVICHGI 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 283 TNLKLMKNGDLLLSDCAAEYHGYTADVTRTVPVnGKFSPEQKIIYELVLAAQDSAIAVCKPGMPYSgsdaTARRVINRGL 362
Cdd:PLN03158  213 PDARKLEDGDIVNVDVTVYYKGCHGDLNETFFV-GNVDEASRQLVKCTYECLEKAIAIVKPGVRYR----EVGEVINRHA 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 363 IALGIAAndmeARRYFPHGTSH--HLGLDV----HDLGIrGNMpfEPGMYLTVEPgiYIPPGSKCDPKW---WSI----G 429
Cdd:PLN03158  288 TMSGLSV----VKSYCGHGIGElfHCAPNIphyaRNKAV-GVM--KAGQVFTIEP--MINAGVWRDRMWpdgWTAvtadG 358

                         250       260
                  ....*....|....*....|....*
gi 1232570517 430 VR---IEDDILITKEGNRNLSAGAP 451
Cdd:PLN03158  359 KRsaqFEHTLLVTETGVEVLTARLP 383
PRK14576 PRK14576
putative endopeptidase; Provisional
 178-447 2.01e-06

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 50.01  E-value: 2.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 178 ELSRMAGVVDSLIKQYKKPIAARTTAQIMTALRGIKQPEEIAILEKAAAISVEGHNEVMKAVKPGMTEYQAQAimeyAFK 257
Cdd:PRK14576  143 ELQAMSNGGKGVLDKVAPGLKLVDSTALFNEIRMIKSPWEIEHLRKSAEITEYGIASAAKKIRVGCTAAELTA----AFK 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 258 kngSEYPGYPSINGAAENACVLHYVTNLKLM------KNGDLLLSDCAAEYHGYTADVTRTVpVNGKFSPEQKIIYELVL 331
Cdd:PRK14576  219 ---AAVMSFPETNFSRFNLISVGDNFSPKIIadttpaKVGDLIKFDCGIDVAGYGADLARTF-VLGEPDKLTQQIYDTIR 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 332 AAQDSAIAVCKPGMPYsgsdataRRVINRGLIALGIAANDMEARRYFPHGTSHHLGLDVHD-LGIRGNMPFEPGMYLTVE 410
Cdd:PRK14576  295 TGHEHMLSMVAPGVKL-------KAVFDSTMAVIKTSGLPHYNRGHLGHGDGVFLGLEEVPfVSTQATETFCPGMVLSLE 367

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1232570517 411 PGIY-IPPGSkcdpkwwsigVRIEDDILITKEGNRNLS 447
Cdd:PRK14576  368 TPYYgIGVGS----------IMLEDMILITDSGFEFLS 395
Creatinase cd01090
Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea.
 218-447 3.23e-03

Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea.


Pssm-ID: 238523 [Multi-domain]  Cd Length: 228  Bit Score: 39.06  E-value: 3.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 218 IAILEKAAAISVEGHNEVMKAVKPGMTEYQ-AQAIMEYAFKKNGSEYP------------GYPSINGAAenacvlHYVTN 284
Cdd:cd01090     1 IALIRHGARIADIGGAAVVEAIREGVPEYEvALAGTQAMVREIAKTFPevelmdtwtwfqSGINTDGAH------NPVTN 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 285 LKLMKnGDLLLSDCAAEYHGYTADVTRTVPVnGKFSPEQKIIYELVLAAQDSAIAVCKPGMpySGSDATARrvINRGLia 364
Cdd:cd01090    75 RKVQR-GDILSLNCFPMIAGYYTALERTLFL-DEVSDAHLKIWEANVAVHERGLELIKPGA--RCKDIAAE--LNEMY-- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232570517 365 lgiAANDMEARRYFPHGtsHHLGLDVHDLG------IRGNMP--FEPGMYLTVEPGIYIP---PGSKcdpkwwsiGVRiE 433
Cdd:cd01090   147 ---REHDLLRYRTFGYG--HSFGVLSHYYGreagleLREDIDtvLEPGMVVSMEPMIMLPegqPGAG--------GYR-E 212

                         250
                  ....*....|....*
gi 1232570517 434 DDILITKE-GNRNLS 447
Cdd:cd01090   213 HDILVINEnGAENIT 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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