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Conserved domains on  [gi|1232315549|gb|OYV96629|]
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MAG: hypothetical protein B7Z73_00395 [Planctomycetia bacterium 21-64-5]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
3-152 3.57e-25

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


:

Pssm-ID: 440354  Cd Length: 136  Bit Score: 98.07  E-value: 3.57e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549   3 PFEKVLVGVDllqadgvgstnFSPPVAEAIKHGLWLAEKSAASVTFFAAIDLPeetiASLGGDAAHMAGQLRTSGGRALD 82
Cdd:COG0589     1 MYKRILVPTD-----------GSEEAERALEYAAELAKALGAELHLLHVVDPP----PSAAAGPEELEEELREEAEEALE 65

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549  83 HLVHEAQARGLTADARLVRGEGWVELTREAERGKYDVVIVGTRNVGAVGRFLFGSTAMKLLHNCPCPVWV 152
Cdd:COG0589    66 EAAERLEEAGVEVETVVREGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
PRK11175 super family cl28723
universal stress protein UspE; Provisional
 4-312 5.03e-20

universal stress protein UspE; Provisional


The actual alignment was detected with superfamily member PRK11175:

Pssm-ID: 236871 [Multi-domain]  Cd Length: 305  Bit Score: 88.40  E-value: 5.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549   4 FEKVLVGVDLLQADgvgstnfSPPVAEAIKhglwLAEKSAASVTFFAAI-DLPEETIASLGGDAAHMAGQLRTSGGRA-L 81
Cdd:PRK11175    3 YQNILVVIDPNQDD-------QPALRRAVY----LAQRNGGKITAFLPIyDFSYEMTTLLSPDEREAMRQGVISQRTAwI 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549  82 DHLVHEAQARGLTADARLVrgegW----VE-LTREAERGKYDVVIVGTRNVGAVGRFLFGSTAMKLLHNCPCPVWVARPE 156
Cdd:PRK11175   72 REQAKPYLDAGIPIEIKVV----WhnrpFEaIIQEVIAGGHDLVVKMTHQHDKLESVIFTPTDWHLLRKCPCPVLMVKDQ 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549 157 PHPLPTSILVASDLS------------------EVAENALrlglalgalsGAKVNLLHAvdYPldrlwST------GLLD 212
Cdd:PRK11175  148 DWPEGGKILVAVNVAseepyhdalneklveeaiDLAEQLN----------HAEVHLVNA--YP-----VTpiniaiELPE 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549 213 TSTQIYHDKVKADARQRLDEqLARVAGPHPAKVelHVAEGLS---IADTAildfirvHHVD--LLLMGTMARGGIPGVFI 287
Cdd:PRK11175  211 FDPSVYNDAIRGQHLLAMKA-LRQKFGIDEEQT--HVEEGLPeevIPDLA-------EHLDaeLVILGTVGRTGLSAAFL 280

                         330       340
                  ....*....|....*....|....*
gi 1232315549 288 GNTAERLVTHVSCSLLAVKPADFIS 312
Cdd:PRK11175  281 GNTAEHVIDHLNCDLLAIKPDGYVS 305
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
3-152 3.57e-25

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 98.07  E-value: 3.57e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549   3 PFEKVLVGVDllqadgvgstnFSPPVAEAIKHGLWLAEKSAASVTFFAAIDLPeetiASLGGDAAHMAGQLRTSGGRALD 82
Cdd:COG0589     1 MYKRILVPTD-----------GSEEAERALEYAAELAKALGAELHLLHVVDPP----PSAAAGPEELEEELREEAEEALE 65

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549  83 HLVHEAQARGLTADARLVRGEGWVELTREAERGKYDVVIVGTRNVGAVGRFLFGSTAMKLLHNCPCPVWV 152
Cdd:COG0589    66 EAAERLEEAGVEVETVVREGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 6-153 7.05e-21

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 86.63  E-value: 7.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549   6 KVLVGVDllqadgvgstnFSPPVAEAIKHGLWLAEKSAASVTFFAAIDLPEETIASLGGDAAHMAgqLRTSGGRALDHLV 85
Cdd:cd00293     1 KILVAVD-----------GSEESERALEWALELAKRPGAELTLLHVVDPPPSSSLSGGLEELADE--LKEEAEELLEEAK 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1232315549  86 HEAQARGLTADARLVRGEGWVELTREAERGKYDVVIVGTRNVGAVGRFLFGSTAMKLLHNCPCPVWVA 153
Cdd:cd00293    68 KLAEEAGVEVETIVVEGDPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLVV 135
PRK11175 PRK11175
universal stress protein UspE; Provisional
 4-312 5.03e-20

universal stress protein UspE; Provisional


Pssm-ID: 236871 [Multi-domain]  Cd Length: 305  Bit Score: 88.40  E-value: 5.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549   4 FEKVLVGVDLLQADgvgstnfSPPVAEAIKhglwLAEKSAASVTFFAAI-DLPEETIASLGGDAAHMAGQLRTSGGRA-L 81
Cdd:PRK11175    3 YQNILVVIDPNQDD-------QPALRRAVY----LAQRNGGKITAFLPIyDFSYEMTTLLSPDEREAMRQGVISQRTAwI 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549  82 DHLVHEAQARGLTADARLVrgegW----VE-LTREAERGKYDVVIVGTRNVGAVGRFLFGSTAMKLLHNCPCPVWVARPE 156
Cdd:PRK11175   72 REQAKPYLDAGIPIEIKVV----WhnrpFEaIIQEVIAGGHDLVVKMTHQHDKLESVIFTPTDWHLLRKCPCPVLMVKDQ 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549 157 PHPLPTSILVASDLS------------------EVAENALrlglalgalsGAKVNLLHAvdYPldrlwST------GLLD 212
Cdd:PRK11175  148 DWPEGGKILVAVNVAseepyhdalneklveeaiDLAEQLN----------HAEVHLVNA--YP-----VTpiniaiELPE 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549 213 TSTQIYHDKVKADARQRLDEqLARVAGPHPAKVelHVAEGLS---IADTAildfirvHHVD--LLLMGTMARGGIPGVFI 287
Cdd:PRK11175  211 FDPSVYNDAIRGQHLLAMKA-LRQKFGIDEEQT--HVEEGLPeevIPDLA-------EHLDaeLVILGTVGRTGLSAAFL 280

                         330       340
                  ....*....|....*....|....*
gi 1232315549 288 GNTAERLVTHVSCSLLAVKPADFIS 312
Cdd:PRK11175  281 GNTAEHVIDHLNCDLLAIKPDGYVS 305
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
164-305 3.92e-19

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 81.89  E-value: 3.92e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549 164 ILVASDLSEVAENALRLGLALGALSGAKVNLLHAVDYPLDRLWSTGLLDtstqiyhDKVKADARQRLDEqLARVAGPHPA 243
Cdd:COG0589     5 ILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAAAGPEELE-------EELREEAEEALEE-AAERLEEAGV 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1232315549 244 KVELHVAEGlSIADtAILDFIRVHHVDLLLMGTMARGGIPGVFIGNTAERLVTHVSCSLLAV 305
Cdd:COG0589    77 EVETVVREG-DPAE-AILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLVV 136
USP-E_repeat2 cd23660
Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP ...
 189-307 3.04e-17

Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467506  Cd Length: 148  Bit Score: 77.31  E-value: 3.04e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549 189 GAKVNLLHAVDYPLDRLwSTGLLDTSTQIYHDKVKADARQRLDEQLARvagPHPAKVELHVAEGLsiADTAILDFIRVHH 268
Cdd:cd23660    36 KAELHLVSAWPVTPENI-AIELPEFDPTEYVDAIRGRHLEAMKALRQK---FGIDEEQTHVLEGL--PEEVIPDFAEELD 109

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1232315549 269 VDLLLMGTMARGGIPGVFIGNTAERLVTHVSCSLLAVKP 307
Cdd:cd23660   110 ADIVVLGTVARTGLSGALIGNTAEHVLDHLNCDLLALKP 148
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 7-154 8.41e-17

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 75.52  E-value: 8.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549   7 VLVGVDllqadgvgstnFSPPVAEAIKHGLWLAEKSAASVTFFAAIDLPEETIASLGGDAAHMAGQLRTSGGRALDHLVH 86
Cdd:pfam00582   1 ILVAVD-----------GSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAAA 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1232315549  87 EAQARGLTADARLVRGEGWVELTREAERGKYDVVIVGTRNVGAVGRFLFGSTAMKLLHNCPCPVWVAR 154
Cdd:pfam00582  70 AAEAGGVKVEVVVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 164-306 1.28e-14

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 69.74  E-value: 1.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549 164 ILVASDLSEVAENALRLGLALGALSGAKVNLLHAVDYPLDRLWSTGLLDTSTQIYHDKvkadARQRLDEQLARVAGPHPA 243
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELE----LAEAEALAAAAAAEAGGV 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1232315549 244 KVELHVAEGlsIADTAILDFIRVHHVDLLLMGTMARGGIPGVFIGNTAERLVTHVSCSLLAVK 306
Cdd:pfam00582  77 KVEVVVVVG--DPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
3-152 3.57e-25

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 98.07  E-value: 3.57e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549   3 PFEKVLVGVDllqadgvgstnFSPPVAEAIKHGLWLAEKSAASVTFFAAIDLPeetiASLGGDAAHMAGQLRTSGGRALD 82
Cdd:COG0589     1 MYKRILVPTD-----------GSEEAERALEYAAELAKALGAELHLLHVVDPP----PSAAAGPEELEEELREEAEEALE 65

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549  83 HLVHEAQARGLTADARLVRGEGWVELTREAERGKYDVVIVGTRNVGAVGRFLFGSTAMKLLHNCPCPVWV 152
Cdd:COG0589    66 EAAERLEEAGVEVETVVREGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 6-153 7.05e-21

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 86.63  E-value: 7.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549   6 KVLVGVDllqadgvgstnFSPPVAEAIKHGLWLAEKSAASVTFFAAIDLPEETIASLGGDAAHMAgqLRTSGGRALDHLV 85
Cdd:cd00293     1 KILVAVD-----------GSEESERALEWALELAKRPGAELTLLHVVDPPPSSSLSGGLEELADE--LKEEAEELLEEAK 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1232315549  86 HEAQARGLTADARLVRGEGWVELTREAERGKYDVVIVGTRNVGAVGRFLFGSTAMKLLHNCPCPVWVA 153
Cdd:cd00293    68 KLAEEAGVEVETIVVEGDPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLVV 135
PRK11175 PRK11175
universal stress protein UspE; Provisional
 4-312 5.03e-20

universal stress protein UspE; Provisional


Pssm-ID: 236871 [Multi-domain]  Cd Length: 305  Bit Score: 88.40  E-value: 5.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549   4 FEKVLVGVDLLQADgvgstnfSPPVAEAIKhglwLAEKSAASVTFFAAI-DLPEETIASLGGDAAHMAGQLRTSGGRA-L 81
Cdd:PRK11175    3 YQNILVVIDPNQDD-------QPALRRAVY----LAQRNGGKITAFLPIyDFSYEMTTLLSPDEREAMRQGVISQRTAwI 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549  82 DHLVHEAQARGLTADARLVrgegW----VE-LTREAERGKYDVVIVGTRNVGAVGRFLFGSTAMKLLHNCPCPVWVARPE 156
Cdd:PRK11175   72 REQAKPYLDAGIPIEIKVV----WhnrpFEaIIQEVIAGGHDLVVKMTHQHDKLESVIFTPTDWHLLRKCPCPVLMVKDQ 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549 157 PHPLPTSILVASDLS------------------EVAENALrlglalgalsGAKVNLLHAvdYPldrlwST------GLLD 212
Cdd:PRK11175  148 DWPEGGKILVAVNVAseepyhdalneklveeaiDLAEQLN----------HAEVHLVNA--YP-----VTpiniaiELPE 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549 213 TSTQIYHDKVKADARQRLDEqLARVAGPHPAKVelHVAEGLS---IADTAildfirvHHVD--LLLMGTMARGGIPGVFI 287
Cdd:PRK11175  211 FDPSVYNDAIRGQHLLAMKA-LRQKFGIDEEQT--HVEEGLPeevIPDLA-------EHLDaeLVILGTVGRTGLSAAFL 280

                         330       340
                  ....*....|....*....|....*
gi 1232315549 288 GNTAERLVTHVSCSLLAVKPADFIS 312
Cdd:PRK11175  281 GNTAEHVIDHLNCDLLAIKPDGYVS 305
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
164-305 3.92e-19

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 81.89  E-value: 3.92e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549 164 ILVASDLSEVAENALRLGLALGALSGAKVNLLHAVDYPLDRLWSTGLLDtstqiyhDKVKADARQRLDEqLARVAGPHPA 243
Cdd:COG0589     5 ILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAAAGPEELE-------EELREEAEEALEE-AAERLEEAGV 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1232315549 244 KVELHVAEGlSIADtAILDFIRVHHVDLLLMGTMARGGIPGVFIGNTAERLVTHVSCSLLAV 305
Cdd:COG0589    77 EVETVVREG-DPAE-AILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLVV 136
USP-E_repeat2 cd23660
Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP ...
 189-307 3.04e-17

Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467506  Cd Length: 148  Bit Score: 77.31  E-value: 3.04e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549 189 GAKVNLLHAVDYPLDRLwSTGLLDTSTQIYHDKVKADARQRLDEQLARvagPHPAKVELHVAEGLsiADTAILDFIRVHH 268
Cdd:cd23660    36 KAELHLVSAWPVTPENI-AIELPEFDPTEYVDAIRGRHLEAMKALRQK---FGIDEEQTHVLEGL--PEEVIPDFAEELD 109

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1232315549 269 VDLLLMGTMARGGIPGVFIGNTAERLVTHVSCSLLAVKP 307
Cdd:cd23660   110 ADIVVLGTVARTGLSGALIGNTAEHVLDHLNCDLLALKP 148
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 7-154 8.41e-17

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 75.52  E-value: 8.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549   7 VLVGVDllqadgvgstnFSPPVAEAIKHGLWLAEKSAASVTFFAAIDLPEETIASLGGDAAHMAGQLRTSGGRALDHLVH 86
Cdd:pfam00582   1 ILVAVD-----------GSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAAA 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1232315549  87 EAQARGLTADARLVRGEGWVELTREAERGKYDVVIVGTRNVGAVGRFLFGSTAMKLLHNCPCPVWVAR 154
Cdd:pfam00582  70 AAEAGGVKVEVVVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 164-306 1.28e-14

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 69.74  E-value: 1.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549 164 ILVASDLSEVAENALRLGLALGALSGAKVNLLHAVDYPLDRLWSTGLLDTSTQIYHDKvkadARQRLDEQLARVAGPHPA 243
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELE----LAEAEALAAAAAAEAGGV 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1232315549 244 KVELHVAEGlsIADTAILDFIRVHHVDLLLMGTMARGGIPGVFIGNTAERLVTHVSCSLLAVK 306
Cdd:pfam00582  77 KVEVVVVVG--DPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 164-305 3.47e-14

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 68.53  E-value: 3.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549 164 ILVASDLSEVAENALRLGLALGALSGAKVNLLHAVDYPldrlwSTGLLDTSTQIYHDKVKADARQRLdEQLARVAGPHPA 243
Cdd:cd00293     2 ILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPP-----PSSSLSGGLEELADELKEEAEELL-EEAKKLAEEAGV 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1232315549 244 KVELHVAEGlsIADTAILDFIRVHHVDLLLMGTMARGGIPGVFIGNTAERLVTHVSCSLLAV 305
Cdd:cd00293    76 EVETIVVEG--DPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLVV 135
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 52-154 1.66e-10

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 58.40  E-value: 1.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549  52 IDLPEETIASLGGDAAHMAGQLRTSGGRALDHLVHEAQA-RGLTADARLVRGEGWVELTREAERGKYDVVIVGTRNVGAV 130
Cdd:cd23659    40 PSLPAASLGSGSEEWEALEEEAREKAEKLLEKYEKKLKEeKGIKVKVEVVAGDPGEVICKAAEELKADLIVMGSRGLGAL 119

                          90       100
                  ....*....|....*....|....
gi 1232315549 131 GRFLFGSTAMKLLHNCPCPVWVAR 154
Cdd:cd23659   120 KRTLLGSVSDYVVHHSPCPVLVVR 143
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 164-306 4.86e-10

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 56.86  E-value: 4.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549 164 ILVASDLSEVAENALRLGLALGALSGAKVNLLHAVDYPLDRLWSTGLLDTSTQIYHDKVKADARQRLDEQLARVAGPHPA 243
Cdd:cd23659     3 VLIAVDGSEESEYALEWALENLHRPGDEVVLLHVIEPPSLPAASLGSGSEEWEALEEEAREKAEKLLEKYEKKLKEEKGI 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1232315549 244 KVELHVAEGLsiADTAILDFIRVHHVDLLLMGTMARGGIPGVFIGNTAERLVTHVSCSLLAVK 306
Cdd:cd23659    83 KVKVEVVAGD--PGEVICKAAEELKADLIVMGSRGLGALKRTLLGSVSDYVVHHSPCPVLVVR 143
USP-A-like cd23657
universal stress protein A and similar proteins; The universal stress protein UspA is a small ...
 164-307 1.10e-06

universal stress protein A and similar proteins; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. In general, these proteins form dimers and have domains for nucleotide binding activity. The crystal structure of Haemophilus influenzae UspA reveals an asymmetric dimer with a tertiary alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, but unlike MJ0577, it lacks ATP-binding activity.


Pssm-ID: 467504  Cd Length: 138  Bit Score: 47.30  E-value: 1.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549 164 ILVASDLSEVAENALRLGLALGALSGAKVNLLHAVDYPLDrlWSTGLLDTSTQIYHDKVKADARQRLDeQLARVAGPHPA 243
Cdd:cd23657     4 ILVAVDLSPESQSLVDKAVEIARENDAKLSLIHVDEDISE--YYTGLIDVDIAALQDLESTMLEEALK-NLSELAGYPVD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1232315549 244 KVelHVAEGlSIADTaILDFIRVHHVDLLLMGTMARGGIPgvFIGNTAERLVTHVSCSLLAVKP 307
Cdd:cd23657    81 HT--FIGYG-DLKEE-ILEVAKKHNVDLIVCGHHGDFGLS--LLGSSARAVLNSAPCDVLIVPL 138
USP-E_repeat1 cd23943
Universal stress protein E, repeat 1; UspE is a tandem-type USP that consists of two USP ...
 108-154 6.63e-04

Universal stress protein E, repeat 1; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467508  Cd Length: 143  Bit Score: 39.46  E-value: 6.63e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1232315549 108 LTREAERGKYDVVIVGTRNVGAVGRFLFGSTAMKLLHNCPCPVWVAR 154
Cdd:cd23943    97 IIQEVIAGNHDLVLKMAHQHDRLESLIFTPTDWHLLRKCPSPVWMVK 143
USP_Rv2623_repeat2 cd23661
universal stress protein Rv2623 and similar proteins, USP repeat 2; Mycobacterium tuberculosis ...
 85-154 2.50e-03

universal stress protein Rv2623 and similar proteins, USP repeat 2; Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth in vitro and in vivo and is required for the entry of the tubercle bacillus into the chronic phase of infection in the host. In addition, Rv2623 binds ATP and the growth-regulatory attribute of this USP is dependent on its ATP-binding activity. Rv2623 is thought to function as an ATP-dependent signaling intermediate in a pathway that promotes persistent infection. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although Usp lacks ATP-binding activity.


Pssm-ID: 467507 [Multi-domain]  Cd Length: 133  Bit Score: 37.49  E-value: 2.50e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315549  85 VHEAQARGLTADARLVRGEGWVELTREAERGkyDVVIVGTRNVGAVGRFLFGSTAMKLLHNCPCPVWVAR 154
Cdd:cd23661    66 GWQERYPDVHVHKVVVRDRPARVLLEASERA--QLVVVGSHGRGGFAGMLLGSVSRAVLHSAPCPVIVVR 133
USP_Rv2623_repeat1 cd23944
universal stress protein Rv2623 and similar proteins, USP repeat 1; Mycobacterium tuberculosis ...
 106-154 2.65e-03

universal stress protein Rv2623 and similar proteins, USP repeat 1; Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth in vitro and in vivo and is required for the entry of the tubercle bacillus into the chronic phase of infection in the host. In addition Rv2623 binds ATP and the growth-regulatory attribute of this USP is dependent on its ATP-binding activity. Rv2623 is thought to function as an ATP-dependent signaling intermediate in a pathway that promotes persistent infection. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although Usp lacks ATP-binding activity.


Pssm-ID: 467509  Cd Length: 140  Bit Score: 37.38  E-value: 2.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1232315549 106 VELTREAErgkydVVIVGTRNVGAVGRFLFGSTAMKLLHNCPCPVWVAR 154
Cdd:cd23944    97 VEASRDAT-----MVVVGSRGIGALAGLLLGSVSTSLVRHAHCPVAVIH 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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