NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1231988177|gb|OYT49581|]
View 

hypothetical protein B6U79_01515, partial [Candidatus Bathyarchaeota archaeon ex4484_231]

Protein Classification

ROK family protein( domain architecture ID 11449187)

ROK (Repressor, ORF, Kinase) family protein functions as a sugar kinase or may act as a transcriptional regulator involved in carbohydrate-dependent transcriptional control

CATH:  3.30.420.40
Gene Ontology:  GO:0005524
PubMed:  20512568|17979299
SCOP:  3000092|4000330

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ASKHA_ATPase-like super family cl49607
ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA ...
 6-205 8.48e-72

ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA superfamily, also known as actin-like ATPase domain superfamily, includes acetate and sugar kinases, heat-shock cognate 70 (Hsp70) and actin family proteins. They either function as conformational hydrolases (e.g. Hsp70, actin) that perform simple ATP hydrolysis, or as metabolite kinases (e.g. glycerol kinase) that catalyze the transfer of a phosphoryl group from ATP to their cognate substrates. Both activities depend on the presence of specific metal cations. ASKHA superfamily members share a common core fold that includes an actin-like ATPase domain consisting of two subdomains (denoted I _ II) with highly similar ribonuclease (RNase) H-like folds. The fold of each subdomain is characterized by a central five strand beta-sheet and flanking alpha-helices. The two subdomains form an active site cleft in which ATP binds at the bottom. Another common feature of ASKHA superfamily members is the coupling of phosphoryl-group transfer to conformational rearrangement, leading to domain closure. Substrate binding triggers protein motion.


The actual alignment was detected with superfamily member cd24063:

Pssm-ID: 483947 [Multi-domain]  Cd Length: 308  Bit Score: 220.29  E-value: 8.48e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   6 KNIVGIGIGSAGPLDLKRGGLMKPTNIPYDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLSTGI 85
Cdd:cd24063    58 DSIEGIGVSSAGPLDLRKGTIVNSPNIKGKEIPLVEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYITISTGI 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  86 GGGIYVDGHLLIGKDGNATEIGHFTIDYDGLLLCGCGKRGHWEAYCSGNGIPNFVRLLIEDK---------NPEEVETS- 155
Cdd:cd24063   138 GGGVIVDGRLLLGKNGNAAEVGHLVVDTESGLKCGCGGYGHWEAFASGRGIPRFAREWAEGFssrtslklrNPGGEGITa 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177 156 ------------LLLKII-----------------------------TLNNGDLVIDPIKRHVKEHARNRVPEIIVTPLG 194
Cdd:cd24063   218 kevfsaarkgdpLALKIIeklaryngrgianvinaydpeliviggsvFNNNKDILDPLIEYLEKNPAISKGPEIVLSELG 297

                         250
                  ....*....|.
gi 1231988177 195 GDVVIYGALAL 205
Cdd:cd24063   298 DDVGLIGALAL 308
 
Name Accession Description Interval E-value
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 6-205 8.48e-72

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 220.29  E-value: 8.48e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   6 KNIVGIGIGSAGPLDLKRGGLMKPTNIPYDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLSTGI 85
Cdd:cd24063    58 DSIEGIGVSSAGPLDLRKGTIVNSPNIKGKEIPLVEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYITISTGI 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  86 GGGIYVDGHLLIGKDGNATEIGHFTIDYDGLLLCGCGKRGHWEAYCSGNGIPNFVRLLIEDK---------NPEEVETS- 155
Cdd:cd24063   138 GGGVIVDGRLLLGKNGNAAEVGHLVVDTESGLKCGCGGYGHWEAFASGRGIPRFAREWAEGFssrtslklrNPGGEGITa 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177 156 ------------LLLKII-----------------------------TLNNGDLVIDPIKRHVKEHARNRVPEIIVTPLG 194
Cdd:cd24063   218 kevfsaarkgdpLALKIIeklaryngrgianvinaydpeliviggsvFNNNKDILDPLIEYLEKNPAISKGPEIVLSELG 297

                         250
                  ....*....|.
gi 1231988177 195 GDVVIYGALAL 205
Cdd:cd24063   298 DDVGLIGALAL 308
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 3-208 3.04e-58

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 185.87  E-value: 3.04e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   3 PQAKNIVGIGIGSAGPLDLKRGGLMKPTNIP-YDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITL 81
Cdd:COG1940    62 ISRGRILGIGIGVPGPVDPETGVVLNAPNLPgWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTL 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  82 STGIGGGIYVDGHLLIGKDGNATEIGHFTIDYDGlLLCGCGKRGHWEAYCSGNGIPNFVRLLIEDKN--PEEVET----- 154
Cdd:COG1940   142 GTGIGGGIVINGKLLRGANGNAGEIGHMPVDPDG-PLCGCGNRGCLETYASGPALLRRARELGGAEKltAEELFAaarag 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177 155 -SLLLKIIT----------------------------LNNGDLVIDPIKRHVKEHARNRV---PEIIVTPLGGDVVIYGA 202
Cdd:COG1940   221 dPLALEVLDeaarylgiglanlinlldpevivlgggvSAAGDLLLEPIREALAKYALPPAredPRIVPASLGDDAGLLGA 300


                  ....*.
gi 1231988177 203 LALAFH 208
Cdd:COG1940   301 AALALE 306
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 4-136 5.10e-39

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 135.93  E-value: 5.10e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   4 QAKNIVGIGIGSAGPLDLKRGGLMKPTNIPYDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLST 83
Cdd:pfam00480  52 KFGELIAVGIGSPGLISPKYGYITNTPNIGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGT 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1231988177  84 GIGGGIYVDGHLLIGKDGNATEIGHFTIDYDGlLLCGCGKRGHWEAYCSGNGI 136
Cdd:pfam00480 132 GVGGGVISNGKLFTGRNGVAGEIGHIQLDPNG-PKCGCGNHGCLETIASGRAL 183
ROK_glcA_fam TIGR00744
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ...
 8-141 3.09e-37

ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]


Pssm-ID: 273246 [Multi-domain]  Cd Length: 318  Bit Score: 131.95  E-value: 3.09e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   8 IVGIGIGSAGPLDLKRGGLMKPTNIPYDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLSTGIGG 87
Cdd:TIGR00744  58 IVAIGIGAPGPVNRQRGTVYFAVNLDWKQEPLKEKVEARVGLPVVVENDANAAALGEYKKGAGKGARDVICITLGTGLGG 137

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1231988177  88 GIYVDGHLLIGKDGNATEIGHFTIDYDGLLLCGCGKRGHWEAYCSGNGIPNFVR 141
Cdd:TIGR00744 138 GIIINGEIRHGHNGVGAEIGHIRMVPDGRLLCNCGKQGCIETYASATGLVRYAK 191
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 38-136 3.05e-21

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 88.82  E-value: 3.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  38 PLVEPLQDALGIPTYLLNDCSTAVMGEKHfGAGKEHENLAYITLSTGIGGGIYVDGHLLIGKDGNATEIGHFTIDYDGlL 117
Cdd:PRK05082   87 PLVQTLEQLTDLPTIALNDAQAAAWAEYQ-ALPDDIRNMVFITVSTGVGGGIVLNGKLLTGPGGLAGHIGHTLADPHG-P 164

                          90
                  ....*....|....*....
gi 1231988177 118 LCGCGKRGHWEAYCSGNGI 136
Cdd:PRK05082  165 VCGCGRRGCVEAIASGRAI 183
 
Name Accession Description Interval E-value
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 6-205 8.48e-72

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 220.29  E-value: 8.48e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   6 KNIVGIGIGSAGPLDLKRGGLMKPTNIPYDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLSTGI 85
Cdd:cd24063    58 DSIEGIGVSSAGPLDLRKGTIVNSPNIKGKEIPLVEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYITISTGI 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  86 GGGIYVDGHLLIGKDGNATEIGHFTIDYDGLLLCGCGKRGHWEAYCSGNGIPNFVRLLIEDK---------NPEEVETS- 155
Cdd:cd24063   138 GGGVIVDGRLLLGKNGNAAEVGHLVVDTESGLKCGCGGYGHWEAFASGRGIPRFAREWAEGFssrtslklrNPGGEGITa 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177 156 ------------LLLKII-----------------------------TLNNGDLVIDPIKRHVKEHARNRVPEIIVTPLG 194
Cdd:cd24063   218 kevfsaarkgdpLALKIIeklaryngrgianvinaydpeliviggsvFNNNKDILDPLIEYLEKNPAISKGPEIVLSELG 297

                         250
                  ....*....|.
gi 1231988177 195 GDVVIYGALAL 205
Cdd:cd24063   298 DDVGLIGALAL 308
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 3-208 3.04e-58

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 185.87  E-value: 3.04e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   3 PQAKNIVGIGIGSAGPLDLKRGGLMKPTNIP-YDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITL 81
Cdd:COG1940    62 ISRGRILGIGIGVPGPVDPETGVVLNAPNLPgWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTL 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  82 STGIGGGIYVDGHLLIGKDGNATEIGHFTIDYDGlLLCGCGKRGHWEAYCSGNGIPNFVRLLIEDKN--PEEVET----- 154
Cdd:COG1940   142 GTGIGGGIVINGKLLRGANGNAGEIGHMPVDPDG-PLCGCGNRGCLETYASGPALLRRARELGGAEKltAEELFAaarag 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177 155 -SLLLKIIT----------------------------LNNGDLVIDPIKRHVKEHARNRV---PEIIVTPLGGDVVIYGA 202
Cdd:COG1940   221 dPLALEVLDeaarylgiglanlinlldpevivlgggvSAAGDLLLEPIREALAKYALPPAredPRIVPASLGDDAGLLGA 300


                  ....*.
gi 1231988177 203 LALAFH 208
Cdd:COG1940   301 AALALE 306
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 1-205 8.56e-46

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 151.85  E-value: 8.56e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   1 KDPQAKNIVGIGIGSAGPLDLKRGGLMKPTNIPYDF-VPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYI 79
Cdd:cd23763    52 EAGVRERILGIGIGVPGPVDPETGIVLFAPNLPWWKnVPLRELLEERLGLPVVVENDANAAALGEAWFGAGRGVRNFVYI 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  80 TLSTGIGGGIYVDGHLLIGKDGNATEIGHFTIdydglllcgcgkrghWEAYCS--GNGIPNFVRLLiedkNPEEVetsll 157
Cdd:cd23763   132 TLGTGIGGGIIIDGKLYRGANGAAGEIGHITV---------------LEEAARylGIGLANLINLL----NPELI----- 187

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1231988177 158 lkIIT---LNNGDLVIDPIKRHVKEHARNRV---PEIIVTPLGGDVVIYGALAL 205
Cdd:cd23763   188 --VLGggvAEAGDLLLEPIREAVRRRALPPLrrrVRIVPSELGDDAGLLGAAAL 239
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 1-207 9.18e-45

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 150.81  E-value: 9.18e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   1 KDPQAKNIVGIGIGSAGPLDLKRGGLMKPTNIP-YDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYI 79
Cdd:cd24059    55 KENIKSKILGIGIGAPGPLDVEKGIILNPPNFPgWENIPLVELLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYI 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  80 TLSTGIGGGIYVDGHLLIGKDGNATEIGHFTIDYDGlLLCGCGKRGHWEAYCS-----------GNGIPNFVRLLIE--- 145
Cdd:cd24059   135 LADEGIGAGIIINGKLYRGVDGYAGEIGHTSIDING-PRCSCGNRGCLELYASipaiekkarsaLGSGRSFQLDIVEalq 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177 146 ------DKNPEEVETSLLLKIITLNN----------------GDLVIDPIKRHVKEHA---RNRVPEIIVTPLGGDVVIY 200
Cdd:cd24059   214 kgdpiaDEVIEEAAKYLGIGLVNLINllnpeaiiiggeliylGERYLEPIEKEVNSRLfgrNAREVRILKSSLGEDAPLL 293


                  ....*..
gi 1231988177 201 GALALAF 207
Cdd:cd24059   294 GAAALVL 300
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 4-136 5.10e-39

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 135.93  E-value: 5.10e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   4 QAKNIVGIGIGSAGPLDLKRGGLMKPTNIPYDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLST 83
Cdd:pfam00480  52 KFGELIAVGIGSPGLISPKYGYITNTPNIGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGT 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1231988177  84 GIGGGIYVDGHLLIGKDGNATEIGHFTIDYDGlLLCGCGKRGHWEAYCSGNGI 136
Cdd:pfam00480 132 GVGGGVISNGKLFTGRNGVAGEIGHIQLDPNG-PKCGCGNHGCLETIASGRAL 183
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 8-187 2.44e-37

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 131.71  E-value: 2.44e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   8 IVGIGIGSAGPLDLKRGGLMKPTNIPYDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLSTGIGG 87
Cdd:cd24061    54 VSAVGVAAAGFVDADRATVLFAPNIAWRNEPLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTDDMVMITVGTGLGG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  88 GIYVDGHLLIGKDGNATEIGHFTIDYDGlLLCGCGKRGHWEAYCSGNGIPNFVRLLIEDkNPEEVETSLLLKIITLNNGd 167
Cdd:cd24061   134 GIVIGGKLLRGAFGIAGEFGHIRVVPDG-LLCGCGSRGCWEQYASGRALVRYAKEAANA-TPEGAAVLLADGSVDGITG- 210

                         170       180
                  ....*....|....*....|
gi 1231988177 168 lvidpikRHVKEHARNRVPE 187
Cdd:cd24061   211 -------KHISEAARAGDPV 223
ROK_glcA_fam TIGR00744
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ...
 8-141 3.09e-37

ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]


Pssm-ID: 273246 [Multi-domain]  Cd Length: 318  Bit Score: 131.95  E-value: 3.09e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   8 IVGIGIGSAGPLDLKRGGLMKPTNIPYDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLSTGIGG 87
Cdd:TIGR00744  58 IVAIGIGAPGPVNRQRGTVYFAVNLDWKQEPLKEKVEARVGLPVVVENDANAAALGEYKKGAGKGARDVICITLGTGLGG 137

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1231988177  88 GIYVDGHLLIGKDGNATEIGHFTIDYDGLLLCGCGKRGHWEAYCSGNGIPNFVR 141
Cdd:TIGR00744 138 GIIINGEIRHGHNGVGAEIGHIRMVPDGRLLCNCGKQGCIETYASATGLVRYAK 191
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 8-208 3.91e-37

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 131.15  E-value: 3.91e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   8 IVGIGIGSAGPLDLKRGGLMKPTNIPYDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLSTGIGG 87
Cdd:cd24076    63 ILGIGVGVPGLVDSEDGVVLLAPNLGWRDVPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGA 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  88 GIYVDGHLLIGKDGNATEIGHFTIDYDGlLLCGCGKRGHWEAYCSGNGIPNFVRLLIEDKNP------------------ 149
Cdd:cd24076   143 GIILDGELYRGASGFAGEIGHMTVDPDG-PPCSCGNRGCWETYASERALLRAAGRLGAGGEPlslaelveaaragdpaal 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177 150 ---EEVETSLLLKIITLNN----------------GDLVIDPIKRHVKEHA---RNRVPEIIVTPLGGDVVIYGALALAF 207
Cdd:cd24076   222 aalEEVGEYLGIGLANLVNtfnpelvvlggalaplGPWLLPPLRAEVARRAlpaPARDVRIVVSRLGEDAAALGAAALAI 301


                  .
gi 1231988177 208 H 208
Cdd:cd24076   302 D 302
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 6-136 3.69e-35

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 125.75  E-value: 3.69e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   6 KNIVGIGIGSAGPLDLKRGGLMKPT-NIP-YDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLST 83
Cdd:cd24068    55 YDIEGIGISSAGQVDPKTGEVIYATdNLPgWTGTNLKEELEERFGLPVAVENDVNCAALAEKWLGAAKGLDDFLCLTLGT 134

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1231988177  84 GIGGGIYVDGHLLIGKDGNATEIGHFTIDYDGlLLCGCGKRGHWEAYCSGNGI 136
Cdd:cd24068   135 GIGGAIILDGRLYRGANGSAGELGHMVVDPGG-RPCCCGGKGCLEQYASGTAL 186
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 8-208 1.16e-32

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 119.58  E-value: 1.16e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   8 IVGIGIGSAGPLDLKRGGLMKPTNIPYDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLSTGIGG 87
Cdd:cd24073    62 LLGIGVGLPGLVDAETGICRWSPLLGWRDVPLAELLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGC 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  88 GIYVDGHLLIGKDGNATEIGHFTIDYDGlLLCGCGKRGHWEAYCSGNGIPNFVRLLIEDKNPEEVET---------SLLL 158
Cdd:cd24073   142 GLVVDGRLYRGAHGGAGEIGHTTVDPDG-PPCRCGKRGCLEAYASDPAILRQAREAGLRGEPLTIEDllaaaragdPAAR 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177 159 KI---------------ITLNN-------------GDLVIDPIKRHVKEHARNRV---PEIIVTPLGGDVVIYGALALAF 207
Cdd:cd24073   221 AIlrragralglalanlVNLLDpeliiisgegvraGDLLFEPMREALRAHVFPGLasdLELVIHPWGDEAWARGAAALAL 300


                  .
gi 1231988177 208 H 208
Cdd:cd24073   301 Q 301
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 11-136 2.90e-32

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 118.20  E-value: 2.90e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  11 IGIGSAGPLDLKRGGLMKPTNIP-YDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLSTGIGGGI 89
Cdd:cd24065    59 VGLGVPGPLDFRRGRVRFAPNIPgLTDFPIRRGLAERLGLPVVLENDANAAALAEHHYGAARGTESSVYVTISTGIGGGL 138

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1231988177  90 YVDGHLLIGKDGNATEIGHFTIDYDGlLLCGCGKRGHWEAYCSGNGI 136
Cdd:cd24065   139 VLGGRVLRGRHGQAGEIGHTTVLPGG-PMCGCGLVGCLEALASGRAL 184
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 2-165 5.35e-32

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 117.78  E-value: 5.35e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   2 DPQAKNIVGIGIGSAGPLDLKRGGLMKPTNIPYDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITL 81
Cdd:cd24062    56 GYSKEDLIGIGVGVPGPVDVETGTVEVAVNLGWKNFPLKDKLEALTGIPVVIDNDANAAALGEMWKGAGQGAKDLVFITL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  82 STGIGGGIYVDGHLLIGKDGNATEIGHFTIDYDGLLLCGCGKRGHWEAYCSGNGIPNFVRLLIedknpEEVETSLLLKII 161
Cdd:cd24062   136 GTGVGGGVIANGKIVHGANGAAGEIGHITVNPEGGAPCNCGKTGCLETVASATGIVRIAREEL-----EEGKGSSALRIL 210


                  ....
gi 1231988177 162 TLNN 165
Cdd:cd24062   211 ALGG 214
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 1-160 3.57e-30

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 113.15  E-value: 3.57e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   1 KDPQAKNIVGIGIGSAGPLDLKRGGLMKPTNIPYDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYIT 80
Cdd:cd24071    55 NKHVEKKLLGIGIAVSGLVDSKKGIVIRSTILGWENVELKKILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICVT 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  81 LSTGIGGGIYVDGHLLIGKDGNATEIGHFTIDYDGlLLCGCGKRGHWEAYCSGNGIPNFVRLLIEDKNPEEVETSLLLKI 160
Cdd:cd24071   135 VGAGIGSSLVIDGKLYTGNFGGAGEIGHMTIQPDG-RKCYCGQKGCLEAYASFEALVNEIKELTESYPLSLLKELEDFEI 213
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 11-136 6.73e-30

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 111.61  E-value: 6.73e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  11 IGIGSAGPLDLKRGGLMKPTNIP-YDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLSTGIGGGI 89
Cdd:cd24069    55 VAVASTGIIRDGVLTALNPKNLGgLSGFPLADALQQLLGVPVVLLNDAQAAAWGEYQAGDGEGVGNLVFITVSTGVGGGL 134

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1231988177  90 YVDGHLLIGKDGNATEIGHFTIDYDGlLLCGCGKRGHWEAYCSGNGI 136
Cdd:cd24069   135 VLNGQLLTGPNGLAGHIGHTLADPPG-PVCGCGRRGCVEAIASGTAI 180
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 8-141 5.74e-28

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 107.20  E-value: 5.74e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   8 IVGIGIGSAGPLDLKRGGLMKPTNIP-YDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLSTGIG 86
Cdd:cd24064    56 LLGIGIGSPGSIDRENGIVRFSPNFPdWRNFPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKGSNHIIGLTLGTGVG 135

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1231988177  87 GGIYVDGHLLIGKDGNATEIGHFTIDYDGlLLCGCGKRGHWEAYCSGNGIPNFVR 141
Cdd:cd24064   136 SGVICHGQLLTGYDGIAAELGHVIVEPNG-PICGCGNRGCVEAFASATAIIRYAR 189
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 8-169 1.90e-26

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 103.26  E-value: 1.90e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   8 IVGIGIGSAGPLDLKRGGLMKPTNI--PYDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLSTGI 85
Cdd:cd24060    60 ILGVGISTGGRVNPREGIVLHSTKLiqEWSSVDLRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVITGTGI 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  86 GGGIYVDGHLLIGKDGNATEIGHFTIDYDGlLLCGCGKRGHWEAYCSGNGIPNFVRLLIEdknpeevETSLLLKIITLNN 165
Cdd:cd24060   140 GGGIILNHELIHGSSFCAAELGHIVVSLDG-PDCMCGSHGCVEAYASGMALQREAKKLHD-------EDLLLVEGMSVTN 211


                  ....
gi 1231988177 166 GDLV 169
Cdd:cd24060   212 DEEV 215
ASKHA_ATPase_ROK_SaXylR-like cd24077
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ...
 7-206 1.10e-25

ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466927 [Multi-domain]  Cd Length: 295  Bit Score: 100.69  E-value: 1.10e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   7 NIVGIGIGSAGPLDlkrgglmkpTN-----IPYDF--VPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAgkEHENLAYI 79
Cdd:cd24077    61 GLVGIGIGIHGIVD---------ENeiiftPYYDLedIDLKEKLEEKFNVPVYLENEANLSALAERTFSE--DYDNLISI 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  80 TLSTGIGGGIYVDGHLLIGKDGNATEIGHFTIDYDGlLLCGCGKRGHWEAYCS------------GNGIPNF--VRLLIE 145
Cdd:cd24077   130 SIHSGIGAGIIINNQLYRGYNGFAGEIGHMIIVPNG-KPCPCGNKGCLEQYASekallkelsekkGLETLTFddLIQLYN 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177 146 DKNPEEVE---------TSLLLKIITLNNGDLVI-------------DPIKRHVKEHARNRVpEIIVTPLGGDVVIYGAL 203
Cdd:cd24077   209 EGDPEALElidqfikylAIGINNIINTFNPEIIIinsslineipellEKIKEQLSSSFNKYV-EILISTLGKNATLLGGA 287


                  ...
gi 1231988177 204 ALA 206
Cdd:cd24077   288 AVA 290
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 6-207 1.85e-22

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 92.23  E-value: 1.85e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   6 KNIVGIGIGSAGPLDLKRGGLMKPTNIP-YDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLSTG 84
Cdd:cd24070    58 LKPAAIVIGVPGTVDKDRRTVISTPNIPgLDGVNLADILENKLGIPVILERDVNLLLLYDMRAGNLDDEGVVLGFYIGTG 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  85 IGGGIYVDGHLLIGKDGNATEIGHFTIdYDGLLLCGCGKRGHWEAYCSG---------NGIP-NFVRLLIEDKNPEEVET 154
Cdd:cd24070   138 IGNAILINGKPLRGKNGVAGELGHIPV-YGNGKPCGCGNTGCLETYASGraleeiaeeHYPDtPILDIFVDHGDEPELDE 216

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1231988177 155 -----SLLLKI-ITLNNGDLVI-------------DPIKRHVKEHARNRVP----EIIVTPLGGDVVIYGALALAF 207
Cdd:cd24070   217 fvedlALAIATeINILDPDAVIlgggvidmkgfprETLEEYIRKHLRKPYPadnlKIIYAELGPEAGVIGAAIYAF 292
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 2-142 2.53e-22

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 91.91  E-value: 2.53e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   2 DPQAKNIVGIGIGSAGPLDlKRGGLMKPTNIP-YDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYIT 80
Cdd:cd24057    51 DARFGVKGPVGIGIPGVID-PEDGTLITANIPaAKGRPLRADLSARLGRPVRIDNDANCFALSEAWDGAGRGYPSVFGLI 129

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  81 LSTGIGGGIYVDGHLLIGKDGNATEIGHFTIDYDGLLL--------CGCGKRGHWEAYCSGNGipnFVRL 142
Cdd:cd24057   130 LGTGVGGGLVVNGRLVGGRSGIAGEWGHGPLPADALLLgydlpvlrCGCGQTGCLETYLSGRG---LERL 196
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 6-166 2.96e-21

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 89.40  E-value: 2.96e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   6 KNIVGIGIGSAGPLDLKRGGLMKPTNIPYDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLSTGI 85
Cdd:cd24072    58 DRVKGIALAIQGLVDSHKGVSLWSPGAPWRNIEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVINLDYGI 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  86 GGGIYVDGHLLIGKDGNATEIGHFTIDYDGlLLCGCGKRGHWEAYCSGNGIPNFVRLLIE----DKNPEEVETSLLLKII 161
Cdd:cd24072   138 GSAIVIDNKLYIGASSGSGEIGHTKVNPDG-ARCDCGRRGCLETVASNSALKRNARVTLKlgpvSADPEKLTMEQLIEAL 216


                  ....*
gi 1231988177 162 TLNNG 166
Cdd:cd24072   217 EEGEP 221
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 38-136 3.05e-21

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 88.82  E-value: 3.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  38 PLVEPLQDALGIPTYLLNDCSTAVMGEKHfGAGKEHENLAYITLSTGIGGGIYVDGHLLIGKDGNATEIGHFTIDYDGlL 117
Cdd:PRK05082   87 PLVQTLEQLTDLPTIALNDAQAAAWAEYQ-ALPDDIRNMVFITVSTGVGGGIVLNGKLLTGPGGLAGHIGHTLADPHG-P 164

                          90
                  ....*....|....*....
gi 1231988177 118 LCGCGKRGHWEAYCSGNGI 136
Cdd:PRK05082  165 VCGCGRRGCVEAIASGRAI 183
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 7-175 5.99e-20

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 85.88  E-value: 5.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   7 NIVGIGIGSAGPLDLKRGGLMKPTNIPYDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLSTGIG 86
Cdd:cd24075    61 RLIAISITLPGLINPKTGVVHYMPHIQVKSWPIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIG 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  87 GGIYVDGHLLIGKDGNATEIGHFTIDYDGlLLCGCGKRGHWEAYCSGNGIPNFVRLLIEDKNPeeveTSLLLKIITL--- 163
Cdd:cd24075   141 AGIIIDGKLFLGQNGNAGEIGHIQIEPLG-ERCHCGNFGCLETVASNAAIEQRVKKLLKQGYA----SQLTLQDCTIkdi 215

                         170
                  ....*....|....*..
gi 1231988177 164 ----NNGD-LVIDPIKR 175
Cdd:cd24075   216 cqaaLNGDqLAQDVIKR 232
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 2-108 5.16e-18

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 79.90  E-value: 5.16e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   2 DPQAKNIVGIGIGSAGPLDLKRG----GLMKPTNIP-YDFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENL 76
Cdd:cd24067    45 REQEEPIDAIGIASFGPIDLNPTsptyGYITTTPKPgWRNFDILGALKRAFPVPVGFDTDVNAAALAEYRWGAAKGLDSL 124

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1231988177  77 AYITLSTGIGGGIYVDGHLLIGKdgNATEIGH 108
Cdd:cd24067   125 AYITVGTGIGVGLVVNGKPVHGL--LHPEMGH 154
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 2-205 1.43e-16

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 76.07  E-value: 1.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   2 DPQAKNIVGIGIGSAGPLDLKRGGLMKPTNIPY-DFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYIT 80
Cdd:cd24152    48 KRYDEEIDGIAISAPGVIDPETGIIYGGGALPYlKGFNLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVIV 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  81 LSTGIGGGIYVDGHLLIGKDGNATEIGHFTIDYDGLLLCGCGKrghweaYCSGNGIPNFVRL--------------LIED 146
Cdd:cd24152   128 LGTGIGGAIIIDGKLYRGSHFFAGEFSYLLTDDDDKDLLFFSG------LASMFGLVKRYNKakglepldgeeifeKYAK 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177 147 KNPEEVE------TSLLLKIITLN---------------NGDLVIDPIKRHVKEHARNRV-----PEIIVTPLGGDVVIY 200
Cdd:cd24152   202 GDEAAKKildeyiRNLAKLIYNIQyildpevivigggisEQPLFIEDLKKEVNEILANRPgsipkPEIKACKFGNDANLL 281


                  ....*
gi 1231988177 201 GALAL 205
Cdd:cd24152   282 GALYN 286
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 11-136 3.08e-14

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 69.93  E-value: 3.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  11 IGIGSAGPLDlKRGGLMKPTNIPY-DFVPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLSTGIGGGI 89
Cdd:cd24066    59 VGIGTPGSIS-PRTGLVKNANSTWlNGKPLKADLEARLGRPVRIENDANCFALSEATDGAGAGAGVVFGVILGTGVGGGI 137

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1231988177  90 YVDGHLLIGKDGNATEIGHFTIDYDGLL-----LCGCGKRGHWEAYCSGNGI 136
Cdd:cd24066   138 VVNGRVLTGANGIAGEWGHNPLPWPDEDelpgpPCYCGKRGCVETFLSGPAL 189
PRK09698 PRK09698
D-allose kinase; Provisional
 8-134 9.95e-14

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 68.47  E-value: 9.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   8 IVGIGIGSAGPLDLKRGGLMKPTNIPY---DFVPLVEPLQDALGIPTYLLNDCSTAVMGE-KHFgagKEHENLAY-ITLS 82
Cdd:PRK09698   62 CHGIVMGFPALVSKDRRTVISTPNLPLtalDLYDLADKLENTLNCPVFFSRDVNLQLLWDvKEN---NLTQQLVLgAYLG 138

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1231988177  83 TGIGGGIYVDGHLLIGKDGNATEIGHFTIdYDGLLLCGCGKRGHWEAYCSGN 134
Cdd:PRK09698  139 TGMGFAVWMNGAPWTGAHGVAGELGHIPL-GDMTQHCGCGNPGCLETNCSGM 189
ASKHA_ATPase_ROK_Mlc cd24074
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ...
 38-164 2.06e-13

ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466924 [Multi-domain]  Cd Length: 322  Bit Score: 67.72  E-value: 2.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  38 PLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLSTGIGGGIYVDGHLLIGKDGNATEIGHFTIDYDGlL 117
Cdd:cd24074    93 PLGEALEQHTGLPVYVQHDISAWTLAERFFGAAKGAKNIIQIVIDDDIGAGVITDGQLLHAGSSRLGELGHTQIDPYG-K 171

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1231988177 118 LCGCGKRGHWEAYCSGNGIPNFVRLLIEDKNPeeveTSLLLKIITLN 164
Cdd:cd24074   172 RCYCGNHGCLETVASIPAILEQANQLLEQSPD----SMLHGQPISIE 214
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 9-112 4.29e-10

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 57.58  E-value: 4.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   9 VGIGIgsagPLDLKRGGLMKPTNIPYDFV--PLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLA-YITLSTGI 85
Cdd:cd24058    58 VGVGF----PGVVRRGVVRTAANLDKSWIgfDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKGVVlVLTLGTGI 133

                          90       100
                  ....*....|....*....|....*..
gi 1231988177  86 GGGIYVDGHLLIGkdgnaTEIGHFTID 112
Cdd:cd24058   134 GSALFVDGHLVPN-----TELGHLEIR 155
PRK13310 PRK13310
N-acetyl-D-glucosamine kinase; Provisional
 11-135 5.83e-10

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 183967 [Multi-domain]  Cd Length: 303  Bit Score: 57.69  E-value: 5.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  11 IGIGSAGPLDlKRGGLMKPTNIPY-DFVPLVEPLQDALGIPTYLLNDCSTAVMGEkhfgAGKEhENLAYIT-----LSTG 84
Cdd:PRK13310   60 VGIGIPGMPE-TEDGTLYAANVPAaSGKPLRADLSARLGRDVRLDNDANCFALSE----AWDD-EFTQYPLvmgliLGTG 133

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  85 IGGGIYVDGHLLIGKDGNATEIGHFTIDYDGLLL---------CGCGKRGHWEAYCSGNG 135
Cdd:PRK13310  134 VGGGLVFNGKPISGRSYITGEFGHMRLPVDALTLlgwdaplrrCGCGQKGCIENYLSGRG 193
PRK13311 PRK13311
N-acetyl-D-glucosamine kinase; Provisional
 9-135 3.51e-08

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 106271 [Multi-domain]  Cd Length: 256  Bit Score: 52.34  E-value: 3.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   9 VGIGIGSAGPLDlkrGGLMKPTNIPYDF-VPLVEPLQDALGIPTYLLNDCSTAVMGEKHFGAGKEHENLAYITLSTGIGG 87
Cdd:PRK13311   60 VGIGIPGLPNAD---DGTVFTANVPSAMgQPLQADLSRLIQREVRIDNDANCFALSEAWDPEFRTYPTVLGLILGTGVGG 136

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1231988177  88 GIYVDGHLLIGKDGNATEIGHFTIDYDGL---------LLCGCGKRGHWEAYCSGNG 135
Cdd:PRK13311  137 GLIVNGSIVSGRNHITGEFGHFRLPVDALdilgadiprVPCGCGHRGCIENYISGRG 193
ASKHA_NBD_GLK cd24008
nucleotide-binding domain (NBD) of glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7. ...
 1-152 6.06e-05

nucleotide-binding domain (NBD) of glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. Glucokinases are mainly found in invertebrates and microorganisms and highly specific for glucose. Glucokinases belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466858 [Multi-domain]  Cd Length: 313  Bit Score: 42.98  E-value: 6.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177   1 KDPQAKNIVGIGIGSAGPLDlkrGGLMKPTNIPYDFvpLVEPLQDALGI-PTYLLNDC-----STAVMGEKHF------G 68
Cdd:cd24008    48 AELGAPRPKAACIAVAGPVD---GGRVRLTNLDWSI--DAAELRKALGIgRVRLLNDFeaaayGLPALGPEDLlvlyggG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231988177  69 AGKEHENLAYITLSTGIGGGIyvdghLLIGKDGN----ATEIGHFTI----DYDGLLLCGCGKRGH----WEAYCSGNGI 136
Cdd:cd24008   123 GPLPGGPRAVLGPGTGLGVAL-----LVPDGDGGyvvlPSEGGHADFapvtEEEAELLEFLRKRFGrsvsYEDVLSGPGL 197

                         170       180
                  ....*....|....*....|...
gi 1231988177 137 PN---FVRLLI----EDKNPEEV 152
Cdd:cd24008   198 ENiyeFLAKLDgaepPDLTAEEI 220
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH