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Conserved domains on  [gi|1227803197|gb|OXX40102|]
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lytic murein transglycosylase, partial [Vibrio sp. V11_P1A41T118]

Protein Classification

LT_MltC_MltE domain-containing protein( domain architecture ID 13013998)

LT_MltC_MltE domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 16-177 1.61e-99

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


:

Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 284.07  E-value: 1.61e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  16 DIVHRASKKYNIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAGRDVFKLVKNKSGEPSPEYLFDPEKNIDTGTA 95
Cdd:cd16893     1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGLPSKSYLFDPENNIDIGTA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  96 YFYILKNRYLKEVSHPTSLEYSMISAYNGGTGGVLNTFSKDRKRAMRDLNSLQPNQVYWALTQKHPNAESRRYLEKVTKF 175
Cdd:cd16893    81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVLKA 160


                  ..
gi 1227803197 176 KK 177
Cdd:cd16893   161 KK 162
 
Name Accession Description Interval E-value
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 16-177 1.61e-99

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 284.07  E-value: 1.61e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  16 DIVHRASKKYNIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAGRDVFKLVKNKSGEPSPEYLFDPEKNIDTGTA 95
Cdd:cd16893     1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGLPSKSYLFDPENNIDIGTA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  96 YFYILKNRYLKEVSHPTSLEYSMISAYNGGTGGVLNTFSKDRKRAMRDLNSLQPNQVYWALTQKHPNAESRRYLEKVTKF 175
Cdd:cd16893    81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVLKA 160


                  ..
gi 1227803197 176 KK 177
Cdd:cd16893   161 KK 162
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
1-179 9.29e-90

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 266.53  E-value: 9.29e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197   1 PMVADHASKRGYKYADIVHRASKKYNIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAGRDVFKLvKNKSGEPSP 80
Cdd:PRK11671  179 NMVPNHLDKRAHKYLPMVRKASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAGKDVFRM-KGKSGQPSR 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  81 EYLFDPEKNIDTGTAYFYILKNRYLKEVSHPTSLEYSMISAYNGGTGGVLNTFSKDRKRAMRDLNSLQPNQVYWALTQKH 160
Cdd:PRK11671  258 SYLFDPANNIDTGTAYLAILQNVYLGGITNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANIINTMSPGDVYQTLTTRH 337

                         170
                  ....*....|....*....
gi 1227803197 161 PNAESRRYLEKVTKFKKEF 179
Cdd:PRK11671  338 PSAESRRYLYKVNTAQKSY 356
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 4-182 2.83e-46

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 152.07  E-value: 2.83e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197   4 ADHASKRGYKYADIVHRASKKYNIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAGRdvfkLVKNKSGEPSPEYL 83
Cdd:COG0741    93 AALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATARR----LGLKLGLGPSPDDL 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  84 FDPEKNIDTGTAYFYILKNRYLKEVshptsleYSMISAYNGGTGGVLNTFSKDRKRAMRdlnslqpnqvywaltqKHPNA 163
Cdd:COG0741   169 FDPETNIRAGAAYLRELLDRFDGDL-------VLALAAYNAGPGRVRRWLRRNGDRDGE----------------IIPYA 225

                         170
                  ....*....|....*....
gi 1227803197 164 ESRRYLEKVTKFKKEFNAG 182
Cdd:COG0741   226 ETRNYVKKVLANYAIYRAG 244
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 21-140 6.04e-34

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 116.25  E-value: 6.04e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  21 ASKKYNIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAGRDVFKlvknksGEPSPEYLFDPEKNIDTGTAYFYIL 100
Cdd:pfam01464   4 AAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGLR------VNPGVDDLFDPEKNIKAGTKYLKEL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1227803197 101 KNRYLKEVshptsleYSMISAYNGGTGGVLNTFSKDRKRA 140
Cdd:pfam01464  78 YKQYGGDL-------WLALAAYNAGPGRVRKWIKNAGAKD 110
 
Name Accession Description Interval E-value
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 16-177 1.61e-99

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 284.07  E-value: 1.61e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  16 DIVHRASKKYNIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAGRDVFKLVKNKSGEPSPEYLFDPEKNIDTGTA 95
Cdd:cd16893     1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGLPSKSYLFDPENNIDIGTA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  96 YFYILKNRYLKEVSHPTSLEYSMISAYNGGTGGVLNTFSKDRKRAMRDLNSLQPNQVYWALTQKHPNAESRRYLEKVTKF 175
Cdd:cd16893    81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVLKA 160


                  ..
gi 1227803197 176 KK 177
Cdd:cd16893   161 KK 162
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
1-179 9.29e-90

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 266.53  E-value: 9.29e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197   1 PMVADHASKRGYKYADIVHRASKKYNIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAGRDVFKLvKNKSGEPSP 80
Cdd:PRK11671  179 NMVPNHLDKRAHKYLPMVRKASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAGKDVFRM-KGKSGQPSR 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  81 EYLFDPEKNIDTGTAYFYILKNRYLKEVSHPTSLEYSMISAYNGGTGGVLNTFSKDRKRAMRDLNSLQPNQVYWALTQKH 160
Cdd:PRK11671  258 SYLFDPANNIDTGTAYLAILQNVYLGGITNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANIINTMSPGDVYQTLTTRH 337

                         170
                  ....*....|....*....
gi 1227803197 161 PNAESRRYLEKVTKFKKEF 179
Cdd:PRK11671  338 PSAESRRYLYKVNTAQKSY 356
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 4-182 2.83e-46

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 152.07  E-value: 2.83e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197   4 ADHASKRGYKYADIVHRASKKYNIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAGRdvfkLVKNKSGEPSPEYL 83
Cdd:COG0741    93 AALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATARR----LGLKLGLGPSPDDL 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  84 FDPEKNIDTGTAYFYILKNRYLKEVshptsleYSMISAYNGGTGGVLNTFSKDRKRAMRdlnslqpnqvywaltqKHPNA 163
Cdd:COG0741   169 FDPETNIRAGAAYLRELLDRFDGDL-------VLALAAYNAGPGRVRRWLRRNGDRDGE----------------IIPYA 225

                         170
                  ....*....|....*....
gi 1227803197 164 ESRRYLEKVTKFKKEFNAG 182
Cdd:COG0741   226 ETRNYVKKVLANYAIYRAG 244
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
9-174 2.87e-41

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 137.79  E-value: 2.87e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197   9 KRGYKYADIVHRASKKYNIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAGRDVFKLVkNKSGEPSPEYLFDPEK 88
Cdd:PRK15470   34 QRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSGRDVYRRM-GWSGEPTTSELKNPER 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  89 NIDTGTAYFYILKNRYLKEVSHPTSLEYSMISAYNGGTGGVLNTFSKDRKRAMRDLNSLQPNQVYWALTQKHPNAESRRY 168
Cdd:PRK15470  113 NISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSDRKKAISKINDLDADEFLEHVARNHPAPQAPRY 192


                  ....*.
gi 1227803197 169 LEKVTK 174
Cdd:PRK15470  193 IYKLEQ 198
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 12-177 2.24e-34

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 118.38  E-value: 2.24e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  12 YKYADIVHRASKKYNIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAgrdvfKLVKNKSGEP--SPEYLFDPEKN 89
Cdd:cd16896     2 LKYREYIEKYAKEYGVDPLLVAAVIKVESNFNPNAVSSKGAIGLMQIMPETA-----EWIAEKLGLEdfSEDDLYDPETN 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  90 IDTGTAYFYILKNRYLKevshptSLEYsMISAYNGGTGGVL-----NTFSKDRKramrDLNslqpnqvywaltqKHPNAE 164
Cdd:cd16896    77 IRLGTWYLSYLLKEFDG------NLVL-ALAAYNAGPGNVDkwlkdGGWSGDGK----TLD-------------QIPFPE 132

                         170
                  ....*....|...
gi 1227803197 165 SRRYLEKVTKFKK 177
Cdd:cd16896   133 TRHYVKKVLKNYK 145
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 21-140 6.04e-34

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 116.25  E-value: 6.04e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  21 ASKKYNIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAGRDVFKlvknksGEPSPEYLFDPEKNIDTGTAYFYIL 100
Cdd:pfam01464   4 AAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGLR------VNPGVDDLFDPEKNIKAGTKYLKEL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1227803197 101 KNRYLKEVshptsleYSMISAYNGGTGGVLNTFSKDRKRA 140
Cdd:pfam01464  78 YKQYGGDL-------WLALAAYNAGPGRVRKWIKNAGAKD 110
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 14-172 9.90e-34

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 116.81  E-value: 9.90e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  14 YADIVHRASKKYNIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAgRDVFKlvKNKSGEPSPEYLFDPEKNIDTG 93
Cdd:cd13401     6 YRDLVERAAKKNGLDPALVYAIIRQESAFDPDAVSPAGALGLMQLMPATA-KDVAK--KLGLPYYSPRDLFDPEYNIRLG 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1227803197  94 TAYFYILKNRYLKevshptSLEYSmISAYNGGTGGVlntfskdrKRAMRDLNSLQPnqVYWALTqkHPNAESRRYLEKV 172
Cdd:cd13401    83 SAYLAELLDRFDG------NPVLA-LAAYNAGPGRV--------RRWLKRRGDLDP--DLWIET--IPFSETRNYVKRV 142
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 29-172 9.06e-25

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 92.66  E-value: 9.06e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  29 EDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAGRDVFKLVKNksgepspeyLFDPEKNIDTGTAYFYILKNRYLKEV 108
Cdd:cd00254     1 PALVLAVIRVESGFNPRAVSPAGARGLMQLMPGTARDLGRRGVDD---------LFDPEENIRAGARYLRELLDRFGGDL 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1227803197 109 shptsleYSMISAYNGGTGGVLNtfskdrkramrdlnslqpnqvyWALTQKHPNAESRRYLEKV 172
Cdd:cd00254    72 -------ELALAAYNAGPGAVDR----------------------WGGGEVPPYKETRNYVQRV 106
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 13-156 2.88e-21

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 89.35  E-value: 2.88e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  13 KYADIVHRASKKYNIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAGRdvFKlVKNksgepspeyLFDPEKNIDT 92
Cdd:COG4623   263 PYDPLFEKYAEEYGLDWRLLAALAYQESHWNPRARSPTGARGLMQLMPATAKE--LG-VDD---------RLDPEQSIRA 330

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1227803197  93 GTAYFYILKNRYLKEVSHPTSLEYSMiSAYNGGTGGVLntfsKDRKRAMRdlNSLQPNqvYWAL 156
Cdd:COG4623   331 GAKYLRWLYDRFPEAIDEPDRWWFAL-AAYNAGPGHVQ----DARRLAKK--QGLDPD--RWFD 385
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 20-172 3.32e-18

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 77.19  E-value: 3.32e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  20 RASKKYNIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAgRDVFklVKNksgepspeyLFDPEKNIDTGTAYFYI 99
Cdd:cd13403     3 KYAEKYGFDWRLLAAQAYQESRFNPNARSPAGARGLMQLMPSTA-RELG--VND---------RLDPEQNIHAGAKYLRY 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1227803197 100 LKNRYLKEVSHPTSLEYSMiSAYNGGTGGVLNTfskdRKRAMR-DLNslqPNQvyWA-LTQKHPNAESRRYLEKV 172
Cdd:cd13403    71 LRDRFPPDIDEPDRLKFAL-AAYNAGPGHVRDA----RRLAKKyGLN---PNV--WFdNVEVLPLLKSPYYDPVV 135
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 14-129 3.15e-13

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 67.01  E-value: 3.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  14 YADIVHRASKKYNIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVPKTAGRDVFKLvkNKSGEPSPEYLFDPEKNIDTG 93
Cdd:PRK11619  479 WNDEFRRYTSGKGIPQSYAMAIARQESAWNPKARSPVGASGLMQIMPGTATHTVKMF--SIPGYSSSSQLLDPETNINIG 556

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1227803197  94 TAYF-YIL----KNRYLKEvshptsleysmiSAYNGGTGGV 129
Cdd:PRK11619  557 TSYLeYVYqqfgNNRILAS------------AAYNAGPGRV 585
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 23-171 5.21e-13

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 62.54  E-value: 5.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  23 KKYNIPEDLIY-AIIktESSFNPYAVSWANAYGLMQVVPKTAGRdvFKLVKNKsgepspeYL---FDPEKNidTGTAYfy 98
Cdd:cd16894     2 LKEGLPEELKYlALV--ESGFNPDAVSSAGAAGLWQFMPATARE--YGLRVDS-------WVderRDPEKS--TRAAA-- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  99 ilknRYLKEVshptsleYSM-------ISAYNGGTGGVlntfskdrKRAMRDLNSLQPNqVYWALTQkhpNAESRRYLEK 171
Cdd:cd16894    67 ----RYLKDL-------YKRfgdwllaLAAYNAGEGRV--------RRAIKRAGTDKWE-DYYRLYL---PAETRRYVPK 123
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 25-132 3.33e-11

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 57.32  E-value: 3.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  25 YNIPEDLIYAIIKTESSFNPYAV-SWANAYGLMQVVPKTA---GRDvfklvKNKSGEPSPeylFDPEKNIDTGTAYfyiL 100
Cdd:cd13399     1 YGVPPGILAAILGVESGFGPNAGgSPAGAQGIAQFMPSTWkayGVD-----GNGDGKADP---FNPEDAIASAANY---L 69

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1227803197 101 KNRYLKEVSHPTSLEYSMISAYNGGTGGVLNT 132
Cdd:cd13399    70 CRHGWDLNAFLGEDNFLALAAYNAGPGAYANA 101
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 25-126 8.46e-11

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 56.38  E-value: 8.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  25 YNIPEDLIYAIIKTESSFNPYAVSwANA-----YGLMQV----VPKTAgrdvfklvknKSGEPSPEYLFDPEKNIDTGTa 95
Cdd:cd13400     1 YGVPPRLLRAIAKVESGFNPNAIN-RNKngsydIGLMQInsiwLPELA----------RYGITREELLNDPCTNIYVGA- 68

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1227803197  96 yfYILKNRYLKEvshptslEYSM--ISAYNGGT 126
Cdd:cd13400    69 --WILARNIKRY-------GNTWkaVGAYNSGT 92
GEWL cd01021
Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; ...
 4-129 1.05e-09

Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; GEWL) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozymes. This family corresponds to human and mouse lysozyme G-like protein 2.


Pssm-ID: 381601 [Multi-domain]  Cd Length: 174  Bit Score: 54.91  E-value: 1.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197   4 ADHASKRGYKYADIVHRASKKYNIPEDLIYAIIKTESSFNpyAVSW-------ANAYGLMQVvpktagrDVfklvknksG 76
Cdd:cd01021    27 AETDLNRLNKYKDCIKQVGKKLCIDPALIAAIISRESRAG--AALDkngwgdhGNGFGLMQV-------DK--------R 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1227803197  77 EPSPEYLFDPEKNIDTGTAyfyILKNrYLKEVS--HPT-SLEYSM---ISAYNGGTGGV 129
Cdd:cd01021    90 YHPPKGAWDSEEHIEQATG---ILID-FIKTVQrkHPSwSPEQQLkggIAAYNAGVGNV 144
mltD PRK10783
membrane-bound lytic murein transglycosylase D; Provisional
 23-65 2.78e-06

membrane-bound lytic murein transglycosylase D; Provisional


Pssm-ID: 182727 [Multi-domain]  Cd Length: 456  Bit Score: 46.27  E-value: 2.78e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1227803197  23 KKYNIPEDLIYAIIkTESSFNPYAVSWANAYGLMQVVPKTaGR 65
Cdd:PRK10783  113 KKRNMPMELVLLPI-VESAFDPHATSGANAAGIWQIIPST-GR 153
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 32-96 4.79e-06

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 42.40  E-value: 4.79e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1227803197  32 IYAIIKTESSFNP--YAVSWANAYGLMQVVPKTAGRDVFKLVKNksgepspeyLFDPEKNIDTGTAY 96
Cdd:cd00442     2 LAAIIGQESGGNKpaNAGSGSGAAGLFQFMPGTWKAYGKNSSSD---------LNDPEASIEAAAKY 59
PHA00368 PHA00368
internal virion protein D
 14-144 1.12e-05

internal virion protein D


Pssm-ID: 222785 [Multi-domain]  Cd Length: 1315  Bit Score: 44.77  E-value: 1.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197   14 YADIVHRASKKYNIPEDLIYAIIKTESSFNPYAVSWANAYGLMQVVpkTAGRDVFKLVKNksgepsPEYLFDPEKNIDTG 93
Cdd:PHA00368    11 YDGLFQKAADAHGVSYDLLRKVGWDESRFNPTAKSPTGPKGLMQFT--KATAKALGLIVD------DDDRLDPELAIDAG 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1227803197   94 TAYFYILKNRYlkevshpTSLEYSMISAYNGGTG------------GVLNTFSKDRKRAMRDL 144
Cdd:PHA00368    83 ARYLADLVGKY-------DGDELKAALAYNQGEGrlgapqleaydkGDFASISEEGRNYLRNL 138
LT_VirB1-like cd16892
VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up ...
 26-131 4.55e-05

VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up type IV secretion systems (T4SS). T4SS are macromolecular assemblies generally composed of VirB1-11 and VirD4 proteins, and are used by bacteria to transport material across their membranes. VirB1 acts as a lytic transglycosylase (LT), and is important with respect to piercing the peptidoglycan layer in the periplasm. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381613 [Multi-domain]  Cd Length: 143  Bit Score: 41.38  E-value: 4.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227803197  26 NIPEDLIYAIIKTESSFNPYAVSW------------------ANAY---------GLMQVvpktagrdvfklvkNKSGEP 78
Cdd:cd16892     8 GVHPETLAAIVQVESGGNPYAIGVnggklsrqpktkaeaiatARQLiaaghnfdvGLGQI--------------NSRNLA 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1227803197  79 ----SPEYLFDPEKNIDTGTAyfyILKNRYLKEVSHPTSLEYSM---ISAYNGG--TGGVLN 131
Cdd:cd16892    74 rlglTVEDVFDPCTNLKAGAT---ILTECYARAKKTGGDGQAALraaLSCYNTGnfTRGFSN 132
PRK15328 PRK15328
type III secretion system invasion protein IagB;
14-58 2.36e-04

type III secretion system invasion protein IagB;


Pssm-ID: 185228 [Multi-domain]  Cd Length: 160  Bit Score: 39.85  E-value: 2.36e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1227803197  14 YADIVHRASKKYNIPEDLIYAIIKTESSFNPYAV----SWANAYGLMQV 58
Cdd:PRK15328   18 WADCWLQAEKMFNIESELLYAIAQQESAMKPGAIghnrDGSTDLGLMQI 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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