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Conserved domains on  [gi|12229836|sp|Q99665|]
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RecName: Full=Interleukin-12 receptor subunit beta-2; Short=IL-12 receptor subunit beta-2; Short=IL-12R subunit beta-2; Short=IL-12R-beta-2; Short=IL-12RB2; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lep_receptor_Ig super family cl05692
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 28-110 5.61e-12

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


The actual alignment was detected with superfamily member pfam06328:

Pssm-ID: 461878  Cd Length: 87  Bit Score: 62.26  E-value: 5.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836    28 CKRGDVTVkPSHVILLGSTVNITCSLKPrQGCFHYSRRNKLILYKFDR------RINFHHGHSlnSQVTGLPLGTT--LF 99
Cdd:pfam06328   1 EPCGHISP-SPPVVRLGSNVTASCILKE-NCCSHLGVEAQIIVWKLGLelipgsQYTVLNDTV--SSVTLPNLNSTraLL 76

                          90
                  ....*....|.
gi 12229836   100 VCKLACINSDE 110
Cdd:pfam06328  77 TCCLLWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 423-511 1.98e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 1.98e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836 423 APRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALiseniKSYICYEIRVYAL 502
Cdd:cd00063   3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGL-----KPGTEYEFRVRAV 77


                ....*....
gi 12229836 503 SGDQGGCSS 511
Cdd:cd00063  78 NGGGESPPS 86
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 224-316 5.84e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 5.84e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836 224 PLPPWDIRIKFQKASvsRCTLYWR----DEGLVLLNRLRYRPSNSRLWNMVNVTKAKG-RHDLLDLKPFTEYEFQISSKl 298
Cdd:cd00063   1 PSPPTNLRVTDVTST--SVTLSWTppedDGGPITGYVVEYREKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAV- 77

                        90
                ....*....|....*...
gi 12229836 299 hlYKGSWSDWSESLRAQT 316
Cdd:cd00063  78 --NGGGESPPSESVTVTT 93
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
368-608 4.62e-08

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.93  E-value: 4.62e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836 368 TGGKAMTQNITGHTSWTTVIPRTGNWAVA------VSAANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTW 441
Cdd:COG3401 174 TSATAAVATTSLTVTSTTLVDGGGDIEPGttyyyrVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSW 253

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836 442 QPPrkDPSAVQEYVVEWRElhPGGDTQVPLNWLRSRPYNVSALISEniKSYiCYEIRVYALSGDQGGCSSILGNSKHKAP 521
Cdd:COG3401 254 DPV--TESDATGYRVYRSN--SGDGPFTKVATVTTTSYTDTGLTNG--TTY-YYRVTAVDAAGNESAPSNVVSVTTDLTP 326

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836 522 LSGP-HINAITEEKGSILISWNsiPVQEqmGCLLHYRIYWKERDSNSQPQLCEIpyrVSQNSHPINSLQPRVTYVLWMTA 600
Cdd:COG3401 327 PAAPsGLTATAVGSSSITLSWT--ASSD--ADVTGYNVYRSTSGGGTYTKIAET---VTTTSYTDTGLTPGTTYYYKVTA 399


                ....*...
gi 12229836 601 LTAAGESS 608
Cdd:COG3401 400 VDAAGNES 407
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 28-110 5.61e-12

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 62.26  E-value: 5.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836    28 CKRGDVTVkPSHVILLGSTVNITCSLKPrQGCFHYSRRNKLILYKFDR------RINFHHGHSlnSQVTGLPLGTT--LF 99
Cdd:pfam06328   1 EPCGHISP-SPPVVRLGSNVTASCILKE-NCCSHLGVEAQIIVWKLGLelipgsQYTVLNDTV--SSVTLPNLNSTraLL 76

                          90
                  ....*....|.
gi 12229836   100 VCKLACINSDE 110
Cdd:pfam06328  77 TCCLLWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 423-511 1.98e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 1.98e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836 423 APRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALiseniKSYICYEIRVYAL 502
Cdd:cd00063   3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGL-----KPGTEYEFRVRAV 77


                ....*....
gi 12229836 503 SGDQGGCSS 511
Cdd:cd00063  78 NGGGESPPS 86
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 224-316 5.84e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 5.84e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836 224 PLPPWDIRIKFQKASvsRCTLYWR----DEGLVLLNRLRYRPSNSRLWNMVNVTKAKG-RHDLLDLKPFTEYEFQISSKl 298
Cdd:cd00063   1 PSPPTNLRVTDVTST--SVTLSWTppedDGGPITGYVVEYREKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAV- 77

                        90
                ....*....|....*...
gi 12229836 299 hlYKGSWSDWSESLRAQT 316
Cdd:cd00063  78 --NGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
368-608 4.62e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.93  E-value: 4.62e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836 368 TGGKAMTQNITGHTSWTTVIPRTGNWAVA------VSAANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTW 441
Cdd:COG3401 174 TSATAAVATTSLTVTSTTLVDGGGDIEPGttyyyrVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSW 253

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836 442 QPPrkDPSAVQEYVVEWRElhPGGDTQVPLNWLRSRPYNVSALISEniKSYiCYEIRVYALSGDQGGCSSILGNSKHKAP 521
Cdd:COG3401 254 DPV--TESDATGYRVYRSN--SGDGPFTKVATVTTTSYTDTGLTNG--TTY-YYRVTAVDAAGNESAPSNVVSVTTDLTP 326

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836 522 LSGP-HINAITEEKGSILISWNsiPVQEqmGCLLHYRIYWKERDSNSQPQLCEIpyrVSQNSHPINSLQPRVTYVLWMTA 600
Cdd:COG3401 327 PAAPsGLTATAVGSSSITLSWT--ASSD--ADVTGYNVYRSTSGGGTYTKIAET---VTTTSYTDTGLTPGTTYYYKVTA 399


                ....*...
gi 12229836 601 LTAAGESS 608
Cdd:COG3401 400 VDAAGNES 407
fn3 pfam00041
Fibronectin type III domain;
423-511 6.04e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.88  E-value: 6.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836   423 APRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELhpggDTQVPLNWLRSRPYNVSALISeNIKSYICYEIRVYAL 502
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK----NSGEPWNEITVPGTTTSVTLT-GLKPGTEYEVRVQAV 76


                  ....*....
gi 12229836   503 SGDQGGCSS 511
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 521-615 8.29e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 8.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836 521 PLSGPHINAITEEKGSILISWNsiPVQEQMGCLLHYRIYWKERDSnSQPQLCEIPyRVSQNSHPINSLQPRVTYVLWMTA 600
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGS-GDWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRA 76

                        90
                ....*....|....*
gi 12229836 601 LTAAGESSHGNEREF 615
Cdd:cd00063  77 VNGGGESPPSESVTV 91
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 521-607 3.03e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 3.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836    521 PLSGPHINAITEEKGSILISWNSiPVQEQMGcllHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSLQPRVTYVLWMTA 600
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEP-PPDDGIT---GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ....*..
gi 12229836    601 LTAAGES 607
Cdd:smart00060  77 VNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
521-607 1.99e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 1.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836   521 PLSGPHINAITEekGSILISWNsiPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYrvSQNSHPINSLQPRVTYVLWMTA 600
Cdd:pfam00041   2 APSNLTVTDVTS--TSLTVSWT--PPPDGNGPITGYEVEYRPKNSGEPWNEITVPG--TTTSVTLTGLKPGTEYEVRVQA 75


                  ....*..
gi 12229836   601 LTAAGES 607
Cdd:pfam00041  76 VNGGGEG 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 224-297 1.38e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 1.38e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12229836    224 PLPPWDIRIKfqKASVSRCTLYWR--DEGLVLLNRLRYRPSN---SRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSK 297
Cdd:smart00060   1 PSPPSNLRVT--DVTSTSVTLSWEppPDDGITGYIVGYRVEYreeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
fn3 pfam00041
Fibronectin type III domain;
256-306 2.19e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.86  E-value: 2.19e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 12229836   256 RLRYRPSNS-RLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWS 306
Cdd:pfam00041  34 EVEYRPKNSgEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 423-508 1.15e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 38.75  E-value: 1.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836    423 APRQVSANSEGMDNILVTWQPPRKDPSavQEYVVEWRELhpggDTQVPLNWLR-SRPYNVSALISENIKSYICYEIRVYA 501
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVE----YREEGSEWKEvNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ....*..
gi 12229836    502 LSGDQGG 508
Cdd:smart00060  77 VNGAGEG 83
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 28-110 5.61e-12

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 62.26  E-value: 5.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836    28 CKRGDVTVkPSHVILLGSTVNITCSLKPrQGCFHYSRRNKLILYKFDR------RINFHHGHSlnSQVTGLPLGTT--LF 99
Cdd:pfam06328   1 EPCGHISP-SPPVVRLGSNVTASCILKE-NCCSHLGVEAQIIVWKLGLelipgsQYTVLNDTV--SSVTLPNLNSTraLL 76

                          90
                  ....*....|.
gi 12229836   100 VCKLACINSDE 110
Cdd:pfam06328  77 TCCLLWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 423-511 1.98e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 1.98e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836 423 APRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALiseniKSYICYEIRVYAL 502
Cdd:cd00063   3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGL-----KPGTEYEFRVRAV 77


                ....*....
gi 12229836 503 SGDQGGCSS 511
Cdd:cd00063  78 NGGGESPPS 86
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 224-316 5.84e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 5.84e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836 224 PLPPWDIRIKFQKASvsRCTLYWR----DEGLVLLNRLRYRPSNSRLWNMVNVTKAKG-RHDLLDLKPFTEYEFQISSKl 298
Cdd:cd00063   1 PSPPTNLRVTDVTST--SVTLSWTppedDGGPITGYVVEYREKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAV- 77

                        90
                ....*....|....*...
gi 12229836 299 hlYKGSWSDWSESLRAQT 316
Cdd:cd00063  78 --NGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
368-608 4.62e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.93  E-value: 4.62e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836 368 TGGKAMTQNITGHTSWTTVIPRTGNWAVA------VSAANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTW 441
Cdd:COG3401 174 TSATAAVATTSLTVTSTTLVDGGGDIEPGttyyyrVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSW 253

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836 442 QPPrkDPSAVQEYVVEWRElhPGGDTQVPLNWLRSRPYNVSALISEniKSYiCYEIRVYALSGDQGGCSSILGNSKHKAP 521
Cdd:COG3401 254 DPV--TESDATGYRVYRSN--SGDGPFTKVATVTTTSYTDTGLTNG--TTY-YYRVTAVDAAGNESAPSNVVSVTTDLTP 326

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836 522 LSGP-HINAITEEKGSILISWNsiPVQEqmGCLLHYRIYWKERDSNSQPQLCEIpyrVSQNSHPINSLQPRVTYVLWMTA 600
Cdd:COG3401 327 PAAPsGLTATAVGSSSITLSWT--ASSD--ADVTGYNVYRSTSGGGTYTKIAET---VTTTSYTDTGLTPGTTYYYKVTA 399


                ....*...
gi 12229836 601 LTAAGESS 608
Cdd:COG3401 400 VDAAGNES 407
fn3 pfam00041
Fibronectin type III domain;
423-511 6.04e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.88  E-value: 6.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836   423 APRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELhpggDTQVPLNWLRSRPYNVSALISeNIKSYICYEIRVYAL 502
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK----NSGEPWNEITVPGTTTSVTLT-GLKPGTEYEVRVQAV 76


                  ....*....
gi 12229836   503 SGDQGGCSS 511
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 521-615 8.29e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 8.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836 521 PLSGPHINAITEEKGSILISWNsiPVQEQMGCLLHYRIYWKERDSnSQPQLCEIPyRVSQNSHPINSLQPRVTYVLWMTA 600
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGS-GDWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRA 76

                        90
                ....*....|....*
gi 12229836 601 LTAAGESSHGNEREF 615
Cdd:cd00063  77 VNGGGESPPSESVTV 91
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 521-607 3.03e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 3.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836    521 PLSGPHINAITEEKGSILISWNSiPVQEQMGcllHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSLQPRVTYVLWMTA 600
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEP-PPDDGIT---GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ....*..
gi 12229836    601 LTAAGES 607
Cdd:smart00060  77 VNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
521-607 1.99e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 1.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836   521 PLSGPHINAITEekGSILISWNsiPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYrvSQNSHPINSLQPRVTYVLWMTA 600
Cdd:pfam00041   2 APSNLTVTDVTS--TSLTVSWT--PPPDGNGPITGYEVEYRPKNSGEPWNEITVPG--TTTSVTLTGLKPGTEYEVRVQA 75


                  ....*..
gi 12229836   601 LTAAGES 607
Cdd:pfam00041  76 VNGGGEG 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 224-297 1.38e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 1.38e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12229836    224 PLPPWDIRIKfqKASVSRCTLYWR--DEGLVLLNRLRYRPSN---SRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSK 297
Cdd:smart00060   1 PSPPSNLRVT--DVTSTSVTLSWEppPDDGITGYIVGYRVEYreeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
fn3 pfam00041
Fibronectin type III domain;
256-306 2.19e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.86  E-value: 2.19e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 12229836   256 RLRYRPSNS-RLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWS 306
Cdd:pfam00041  34 EVEYRPKNSgEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 423-508 1.15e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 38.75  E-value: 1.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12229836    423 APRQVSANSEGMDNILVTWQPPRKDPSavQEYVVEWRELhpggDTQVPLNWLR-SRPYNVSALISENIKSYICYEIRVYA 501
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVE----YREEGSEWKEvNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ....*..
gi 12229836    502 LSGDQGG 508
Cdd:smart00060  77 VNGAGEG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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