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Conserved domains on  [gi|121646761|gb|ABM64095|]
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adenylate kinase, partial [Escherichia coli]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11478412)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

CATH:  3.40.50.300
EC:  2.7.4.-
Gene Ontology:  GO:0050145|GO:0016310|GO:0046872
PubMed:  2841070
SCOP:  3002021

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
adk PRK00279
adenylate kinase; Reviewed
 1-149 1.30e-100

adenylate kinase; Reviewed


:

Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 287.43  E-value: 1.30e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   1 YGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQADAM----KEA 76
Cdd:PRK00279  24 YGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNGFLLDGFPRTIPQAEALdemlKEL 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 121646761  77 GINVDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVKFNPPKVEGKDDVTGEELTTRKDDQEETVRKRLVEYH 149
Cdd:PRK00279 104 GIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQRADDNEETVRKRLEVYH 176
 
Name Accession Description Interval E-value
adk PRK00279
adenylate kinase; Reviewed
 1-149 1.30e-100

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 287.43  E-value: 1.30e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   1 YGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQADAM----KEA 76
Cdd:PRK00279  24 YGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNGFLLDGFPRTIPQAEALdemlKEL 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 121646761  77 GINVDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVKFNPPKVEGKDDVTGEELTTRKDDQEETVRKRLVEYH 149
Cdd:PRK00279 104 GIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQRADDNEETVRKRLEVYH 176
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1-149 7.15e-96

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 275.08  E-value: 7.15e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   1 YGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQADAM----KEA 76
Cdd:COG0563   24 YGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCANGFILDGFPRTVAQAEALdellAEL 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 121646761  77 GINVDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVKFNPPKVEGKDDVTGEELTTRKDDQEETVRKRLVEYH 149
Cdd:COG0563  104 GIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQRADDNEETVRKRLEVYH 176
ADK pfam00406
Adenylate kinase;
1-149 3.64e-90

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 259.93  E-value: 3.64e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761    1 YGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQADA---MKEAG 77
Cdd:pfam00406  20 YGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKNGFLLDGFPRTVPQAEAleeLLERG 99

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121646761   78 INVDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVKFNPPKVEGKDDVTGEELTTRKDDQEETVRKRLVEYH 149
Cdd:pfam00406 100 IKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNEETVKKRLETYH 171
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1-149 3.70e-73

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 217.87  E-value: 3.70e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761    1 YGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQE-DCRNGFLLDGFPRTIPQADAMKEAGIN 79
Cdd:TIGR01351  23 YGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNdDNENGFILDGFPRTLSQAEALDALLEE 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 121646761   80 -VDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVKFNPPKVEGKDDVTGEELTTRKDDQEETVRKRLVEYH 149
Cdd:TIGR01351 103 pIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDDTEEVVKKRLEVYK 173
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1-149 5.86e-70

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 209.02  E-value: 5.86e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   1 YGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQA---DAMKEAG 77
Cdd:cd01428   23 YGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKGFILDGFPRTVDQAealDELLDEG 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121646761  78 INVDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVkfnppkveGKDDVTGEELTTRKDDQEETVRKRLVEYH 149
Cdd:cd01428  103 IKPDKVIELDVPDEVLIERILGRRICPVSGRVYHL--------GKDDVTGEPLSQRSDDNEETIKKRLEVYK 166
 
Name Accession Description Interval E-value
adk PRK00279
adenylate kinase; Reviewed
 1-149 1.30e-100

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 287.43  E-value: 1.30e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   1 YGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQADAM----KEA 76
Cdd:PRK00279  24 YGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNGFLLDGFPRTIPQAEALdemlKEL 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 121646761  77 GINVDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVKFNPPKVEGKDDVTGEELTTRKDDQEETVRKRLVEYH 149
Cdd:PRK00279 104 GIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQRADDNEETVRKRLEVYH 176
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1-149 7.15e-96

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 275.08  E-value: 7.15e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   1 YGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQADAM----KEA 76
Cdd:COG0563   24 YGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCANGFILDGFPRTVAQAEALdellAEL 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 121646761  77 GINVDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVKFNPPKVEGKDDVTGEELTTRKDDQEETVRKRLVEYH 149
Cdd:COG0563  104 GIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQRADDNEETVRKRLEVYH 176
ADK pfam00406
Adenylate kinase;
1-149 3.64e-90

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 259.93  E-value: 3.64e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761    1 YGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQADA---MKEAG 77
Cdd:pfam00406  20 YGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKNGFLLDGFPRTVPQAEAleeLLERG 99

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121646761   78 INVDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVKFNPPKVEGKDDVTGEELTTRKDDQEETVRKRLVEYH 149
Cdd:pfam00406 100 IKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNEETVKKRLETYH 171
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1-149 3.70e-73

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 217.87  E-value: 3.70e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761    1 YGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQE-DCRNGFLLDGFPRTIPQADAMKEAGIN 79
Cdd:TIGR01351  23 YGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNdDNENGFILDGFPRTLSQAEALDALLEE 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 121646761   80 -VDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVKFNPPKVEGKDDVTGEELTTRKDDQEETVRKRLVEYH 149
Cdd:TIGR01351 103 pIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDDTEEVVKKRLEVYK 173
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1-149 5.86e-70

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 209.02  E-value: 5.86e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   1 YGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQA---DAMKEAG 77
Cdd:cd01428   23 YGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKGFILDGFPRTVDQAealDELLDEG 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121646761  78 INVDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVkfnppkveGKDDVTGEELTTRKDDQEETVRKRLVEYH 149
Cdd:cd01428  103 IKPDKVIELDVPDEVLIERILGRRICPVSGRVYHL--------GKDDVTGEPLSQRSDDNEETIKKRLEVYK 166
PLN02674 PLN02674
adenylate kinase
 1-149 5.32e-51

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 162.75  E-value: 5.32e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   1 YGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQADAMKEA---- 76
Cdd:PLN02674  55 YCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKKPSCQKGFILDGFPRTVVQAQKLDEMlakq 134

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 121646761  77 GINVDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVKFNPPKVEGKDDVTGEELTTRKDDQEETVRKRLVEYH 149
Cdd:PLN02674 135 GAKIDKVLNFAIDDAILEERITGRWIHPSSGRTYHTKFAPPKVPGVDDVTGEPLIQRKDDTAAVLKSRLEAFH 207
PLN02842 PLN02842
nucleotide kinase
 1-149 2.23e-45

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 154.63  E-value: 2.23e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   1 YGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQED-CRNGFLLDGFPRTIPQADAMKEAGIN 79
Cdd:PLN02842  21 FGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDaKEKGWLLDGYPRSFAQAQSLEKLKIR 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761  80 VDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVKFNPPkvegKDDVTGEELTTRKDDQEETVRKRLVEYH 149
Cdd:PLN02842 101 PDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPP----ESEEIKARLITRPDDTEEKVKARLQIYK 166
PRK14528 PRK14528
adenylate kinase; Provisional
 1-149 5.29e-40

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 132.83  E-value: 5.29e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   1 YGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQADA----MKEA 76
Cdd:PRK14528  25 LSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKNGFLLDGFPRTVEQADAldalLKNE 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 121646761  77 GINVDYVLEFDVPDELIVDRIVGRRVhapsgrvyhvkfnppkVEGkddvtgeelttRKDDQEETVRKRLVEYH 149
Cdd:PRK14528 105 GKSIDKAINLEVPDGELLKRLLGRAE----------------IEG-----------RADDNEATIKNRLDNYN 150
adk PRK02496
adenylate kinase; Provisional
 2-149 9.49e-38

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 126.79  E-value: 9.49e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   2 GIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQADA----MKEAG 77
Cdd:PRK02496  26 HIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAANGWILDGFPRKVTQAAFldelLQEIG 105

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121646761  78 INVDYVLEFDVPDELIVDRIVGRrvhapsgrvyhvkfnppkvegkddvtgeeltTRKDDQEETVRKRLVEYH 149
Cdd:PRK02496 106 QSGERVVNLDVPDDVVVERLLAR-------------------------------GRKDDTEEVIRRRLEVYR 146
PRK13808 PRK13808
adenylate kinase; Provisional
 1-148 4.95e-36

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 126.54  E-value: 4.95e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   1 YGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQADA----MKEA 76
Cdd:PRK13808  24 YGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAANGFILDGFPRTVPQAEAldalLKDK 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121646761  77 GINVDYVLEFDVPDELIVDRiVGRRVHAPSGRvyhvkfnppkvegkddvtGEELttRKDDQEETVRKRLVEY 148
Cdd:PRK13808 104 QLKLDAVVELRVNEGALLAR-VETRVAEMRAR------------------GEEV--RADDTPEVLAKRLASY 154
PRK14532 PRK14532
adenylate kinase; Provisional
 2-149 9.48e-35

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 119.54  E-value: 9.48e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   2 GIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQA---DAMKEA-G 77
Cdd:PRK14532  25 GMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEAAGGAIFDGFPRTVAQAealDKMLASrG 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121646761  78 INVDYVLEFDVPDELIVDRIVGRrvHAPSGrvyhvkfnppkvegkddvtgeelttRKDDQEETVRKRLVEYH 149
Cdd:PRK14532 105 QKIDVVIRLKVDDEALIERIVKR--FEEQG-------------------------RPDDNPEVFVTRLDAYN 149
PRK14530 PRK14530
adenylate kinase; Provisional
 1-145 8.16e-34

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 117.97  E-value: 8.16e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   1 YGIPQISTGDMLRA-AVKSGSELGKQ---AKDIMDAGKLVTDELVIALVKERIAQEDcrnGFLLDGFPRTIPQADAMKEA 76
Cdd:PRK14530  27 FGVEHVTTGDALRAnKQMDISDMDTEydtPGEYMDAGELVPDAVVNEIVEEALSDAD---GFVLDGYPRNLEQAEYLESI 103

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 121646761  77 gINVDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVKFNPPKVEGKDDVTGEELTTRKDDQEETVRKRL 145
Cdd:PRK14530 104 -TDLDVVLYLDVSEEELVDRLTGRRVCPDCGANYHVEFNQPEEEGVCDECGGELIQRDDDTEETVRERL 171
PLN02459 PLN02459
probable adenylate kinase
 2-148 4.98e-32

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 114.56  E-value: 4.98e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   2 GIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERI--AQEDCRNGFLLDGFPRTIPQADAMKEAgIN 79
Cdd:PLN02459  54 GVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLeaGEEEGESGFILDGFPRTVRQAEILEGV-TD 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761  80 VDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVKfnPPKVEGKDDVTG-------------EELTTRKDDQEETVRKRLV 146
Cdd:PLN02459 133 IDLVVNLKLREEVLVEKCLGRRICSECGKNFNVA--DIDLKGEDGRPGivmppllpppecaSKLITRADDTEEVVKARLR 210


                 ..
gi 121646761 147 EY 148
Cdd:PLN02459 211 VY 212
PRK14527 PRK14527
adenylate kinase; Provisional
 2-148 3.48e-31

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 110.26  E-value: 3.48e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   2 GIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQ-EDCRngFLLDGFPRTIPQADA----MKEA 76
Cdd:PRK14527  31 GLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDELAGmEPVR--VIFDGFPRTLAQAEAldrlLEEL 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121646761  77 GINVDYVLEFDVPDELIVDRIVGRrvhapsgrvyhvkfnppkvegkddvtgEELTTRKDDQEETVRKRLVEY 148
Cdd:PRK14527 109 GARLLAVVLLEVPDEELIRRIVER---------------------------ARQEGRSDDNEETVRRRQQVY 153
PRK14529 PRK14529
adenylate kinase; Provisional
 1-144 2.99e-30

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 108.65  E-value: 2.99e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   1 YGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIaQEDCRNGFLLDGFPRTIPQA----DAMKEA 76
Cdd:PRK14529  24 YDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETL-KQDGKNGWLLDGFPRNKVQAeklwEALQKE 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 121646761  77 GINVDYVLEFDVPDELIVDRIVGRRVHA-PSGRVYHVKFNPPKVEGKD-DVTGEELTTRKDDQ-EETVRKR 144
Cdd:PRK14529 103 GMKLDYVIEILLPREVAKNRIMGRRLCKnDNNHPNNIFIDAIKPDGDVcRVCGGELSTRADDQdEEAINKR 173
PRK14526 PRK14526
adenylate kinase; Provisional
 5-149 5.68e-29

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 105.32  E-value: 5.68e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   5 QISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQADAMKEAGINVDyVL 84
Cdd:PRK14526  28 HISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKNNDNFILDGFPRNINQAKALDKFLPNIK-II 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 121646761  85 EFDVPDELIVDRIVGRRVHAPSGRVYHVKFNPPKVEGKDDVTGEELTTRKDDQEETVRKRLVEYH 149
Cdd:PRK14526 107 NFLIDEELLIKRLSGRRICKSCNNIFNIYTLPTKEKGICDVCKGDLYQRKDDKEESLKTRLQEYK 171
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 3-148 8.57e-27

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 99.87  E-value: 8.57e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   3 IPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQ--EDCRNGFLLDGFPRTIPQAdamKEAGI-- 78
Cdd:PTZ00088  32 LKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKvtDDCFKGFILDGFPRNLKQC---KELGKit 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761  79 NVDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHV------KFNPPKVEGKDDVTG----EELTTRKDDQEETVRKRLVEY 148
Cdd:PTZ00088 109 NIDLFVNIYLPRNILIKKLLGRRICNTCNRNFNIahirsdPYDMPPILPPADCEGckgnPKLQKRSDDTEEIVAHRLNTY 188
PRK14531 PRK14531
adenylate kinase; Provisional
 1-148 5.82e-25

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 94.11  E-value: 5.82e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   1 YGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIaQEDCRNGFLLDGFPRTIPQADAMK----EA 76
Cdd:PRK14531  26 HGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQL-KALNSGGWLLDGFPRTVAQAEALEplleEL 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121646761  77 GINVDYVLEFDVPDELIVDRIVGRrvhapsgrvyhvkfnppkvegkddvtgeeltTRKDDQEETVRKRLVEY 148
Cdd:PRK14531 105 KQPIEAVVLLELDDAVLIERLLAR-------------------------------GRADDNEAVIRNRLEVY 145
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 1-149 9.84e-25

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 93.73  E-value: 9.84e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761    1 YGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERI-AQEDCRNGFLLDGFPRTIPQADAMKEAGIN 79
Cdd:TIGR01360  27 YGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMvAALGTSKGFLIDGYPREVKQGEEFERRIGP 106

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   80 VDYVLEFDVPDELIVDRIVGRRvhAPSGRVyhvkfnppkvegkddvtgeelttrkDDQEETVRKRLVEYH 149
Cdd:TIGR01360 107 PTLVLYFDCSEDTMVKRLLKRA--ETSGRV-------------------------DDNEKTIKKRLETYY 149
AAA_17 pfam13207
AAA domain;
1-101 8.09e-20

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 79.59  E-value: 8.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761    1 YGIPQISTGDMLRAAVKSGSelGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQADAMKE----- 75
Cdd:pfam13207  19 LGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERIAEEAGEGGVIVDGHPRIKTPAGYLPGlpvev 96

                          90       100
                  ....*....|....*....|....*..
gi 121646761   76 -AGINVDYVLEFDVPDELIVDRIVGRR 101
Cdd:pfam13207  97 lRELKPDAIILLEADPEEILERRLKDR 123
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 1-149 2.07e-19

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 79.72  E-value: 2.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761    1 YGIPQISTGDMLRAAVK-SGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQADA---MKEA 76
Cdd:TIGR01359  23 FGFTHLSAGDLLRAEIKrEGSENGSLIESYIKEGKIVPSEVTVELLKKAIQEDGSSKKFLIDGFPRNEENLEAwekLMDN 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 121646761   77 GINVDYVLEFDVPDELIVDRIVGRRVhaPSGRVyhvkfnppkvegkddvtgeelttrkDDQEETVRKRLVEYH 149
Cdd:TIGR01359 103 KVNFKFVLFFDCPEETMIKRLLKRGQ--TSGRV-------------------------DDNIETLKKRFRTYN 148
ADK_lid pfam05191
Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular ...
 100-135 4.31e-18

Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organizms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function.


Pssm-ID: 461578 [Multi-domain]  Cd Length: 36  Bit Score: 72.11  E-value: 4.31e-18
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 121646761  100 RRVHAPSGRVYHVKFNPPKVEGKDDVTGEELTTRKD 135
Cdd:pfam05191   1 RRVCPKCGRIYHVYFNPPKVEGVCDVCGGELVQRDD 36
PLN02200 PLN02200
adenylate kinase family protein
 1-145 1.38e-13

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 65.30  E-value: 1.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121646761   1 YGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDcRNGFLLDGFPRTIPQADAMKEA-GIN 79
Cdd:PLN02200  67 FGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESSD-NNKFLIDGFPRTEENRIAFERIiGAE 145

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 121646761  80 VDYVLEFDVPDELIVDRIVGRRvhapSGRVyhvkfnppkvegkddvtgeelttrkDDQEETVRKRL 145
Cdd:PLN02200 146 PNVVLFFDCPEEEMVKRVLNRN----QGRV-------------------------DDNIDTIKKRL 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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