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Conserved domains on  [gi|121588511|gb|ABM61091|]
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Lytic transglycosylase, catalytic [Halorhodospira halophila SL1]

Protein Classification

LT_MltC_MltE domain-containing protein( domain architecture ID 13013998)

LT_MltC_MltE domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 217-380 2.11e-98

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


:

Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 289.46  E-value: 2.11e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 217 EDVEAEAERYDVDPALMLAVMHSESSFNPMARSHIPAYGLMQIVPESAGRDVAQRVYGEQRLFSPDYLYNPDNNIRAGAV 296
Cdd:cd16893    1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGLPSKSYLFDPENNIDIGTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 297 YLDILDSSYLSAIEDPESRLYAVISAYNTGAGNVARAFvdGTNVSAAAEVINDMSPDEVYETLAENLPYEETRNYLVNVA 376
Cdd:cd16893   81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTF--SSDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVL 158


                 ....
gi 121588511 377 SRHQ 380
Cdd:cd16893  159 KAKK 162
 
Name Accession Description Interval E-value
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 217-380 2.11e-98

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 289.46  E-value: 2.11e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 217 EDVEAEAERYDVDPALMLAVMHSESSFNPMARSHIPAYGLMQIVPESAGRDVAQRVYGEQRLFSPDYLYNPDNNIRAGAV 296
Cdd:cd16893    1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGLPSKSYLFDPENNIDIGTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 297 YLDILDSSYLSAIEDPESRLYAVISAYNTGAGNVARAFvdGTNVSAAAEVINDMSPDEVYETLAENLPYEETRNYLVNVA 376
Cdd:cd16893   81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTF--SSDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVL 158


                 ....
gi 121588511 377 SRHQ 380
Cdd:cd16893  159 KAKK 162
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
162-383 1.59e-59

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 196.81  E-value: 1.59e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 162 QRVLSEISAEDVEEMMAQAKAEQRQEpegdGRRDILSFSVPMPESRASDKAEEFREDVEAEAERYDVDPALMLAVMHSES 241
Cdd:PRK11671 143 QPIRWEGRASNFADYLLQNKLQSRSN----GLRIIYSVTINMVPNHLDKRAHKYLPMVRKASRKYGVDESLILAIMQTES 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 242 SFNPMARSHIPAYGLMQIVPESAGRDVAQRvYGEQRLFSPDYLYNPDNNIRAGAVYLDILDSSYLSAIEDPESRLYAVIS 321
Cdd:PRK11671 219 SFNPYAVSRSDALGLMQVVQHTAGKDVFRM-KGKSGQPSRSYLFDPANNIDTGTAYLAILQNVYLGGITNPTSRRYAVIT 297

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121588511 322 AYNTGAGNVARAFVDGTNvsAAAEVINDMSPDEVYETLAENLPYEETRNYLVNVASRHQAYR 383
Cdd:PRK11671 298 AYNGGAGSVLRVFSNDKI--QAANIINTMSPGDVYQTLTTRHPSAESRRYLYKVNTAQKSYR 357
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 113-383 3.71e-37

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 134.74  E-value: 3.71e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 113 AVQAAAQRLDELLQTTLAEAYEGDEVTQRTWDRLDIPESETTAAGNSDEQRVLSEISAEDVEEMMAQAKAEQRQEPEGDG 192
Cdd:COG0741    1 AAAAAAAAAALALAASAAAALALALLAAAAAAAALAAAAAALAAAAAAAAGAAAAAASAAAGGPALAAALAAADALAAFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 193 RRDILSFSVPMPESRASDKAEEFREDVEAEAERYDVDPALMLAVMHSESSFNPMARSHIPAYGLMQIVPESAgRDVAQRV 272
Cdd:COG0741   81 AIAALAAELLALAALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATA-RRLGLKL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 273 ygeQRLFSPDYLYNPDNNIRAGAVYLDILDSSYLsaiedpeSRLYAVISAYNTGAGNVARAFVDGTNVSaaaevindmsp 352
Cdd:COG0741  160 ---GLGPSPDDLFDPETNIRAGAAYLRELLDRFD-------GDLVLALAAYNAGPGRVRRWLRRNGDRD----------- 218

                        250       260       270
                 ....*....|....*....|....*....|.
gi 121588511 353 devyetlAENLPYEETRNYLVNVASRHQAYR 383
Cdd:COG0741  219 -------GEIIPYAETRNYVKKVLANYAIYR 242
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 221-334 9.22e-26

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 100.07  E-value: 9.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511  221 AEAERYDVDPALMLAVMHSESSFNPMARSHIPAYGLMQIVPESAGRdvaqrvYGEQRLFSPDYLYNPDNNIRAGAVYLDI 300
Cdd:pfam01464   3 KAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKR------LGLRVNPGVDDLFDPEKNIKAGTKYLKE 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 121588511  301 LDSSYLsaiedpeSRLYAVISAYNTGAGNVARAF 334
Cdd:pfam01464  77 LYKQYG-------GDLWLALAAYNAGPGRVRKWI 103
 
Name Accession Description Interval E-value
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 217-380 2.11e-98

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 289.46  E-value: 2.11e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 217 EDVEAEAERYDVDPALMLAVMHSESSFNPMARSHIPAYGLMQIVPESAGRDVAQRVYGEQRLFSPDYLYNPDNNIRAGAV 296
Cdd:cd16893    1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGLPSKSYLFDPENNIDIGTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 297 YLDILDSSYLSAIEDPESRLYAVISAYNTGAGNVARAFvdGTNVSAAAEVINDMSPDEVYETLAENLPYEETRNYLVNVA 376
Cdd:cd16893   81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTF--SSDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVL 158


                 ....
gi 121588511 377 SRHQ 380
Cdd:cd16893  159 KAKK 162
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
162-383 1.59e-59

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 196.81  E-value: 1.59e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 162 QRVLSEISAEDVEEMMAQAKAEQRQEpegdGRRDILSFSVPMPESRASDKAEEFREDVEAEAERYDVDPALMLAVMHSES 241
Cdd:PRK11671 143 QPIRWEGRASNFADYLLQNKLQSRSN----GLRIIYSVTINMVPNHLDKRAHKYLPMVRKASRKYGVDESLILAIMQTES 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 242 SFNPMARSHIPAYGLMQIVPESAGRDVAQRvYGEQRLFSPDYLYNPDNNIRAGAVYLDILDSSYLSAIEDPESRLYAVIS 321
Cdd:PRK11671 219 SFNPYAVSRSDALGLMQVVQHTAGKDVFRM-KGKSGQPSRSYLFDPANNIDTGTAYLAILQNVYLGGITNPTSRRYAVIT 297

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121588511 322 AYNTGAGNVARAFVDGTNvsAAAEVINDMSPDEVYETLAENLPYEETRNYLVNVASRHQAYR 383
Cdd:PRK11671 298 AYNGGAGSVLRVFSNDKI--QAANIINTMSPGDVYQTLTTRHPSAESRRYLYKVNTAQKSYR 357
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 113-383 3.71e-37

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 134.74  E-value: 3.71e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 113 AVQAAAQRLDELLQTTLAEAYEGDEVTQRTWDRLDIPESETTAAGNSDEQRVLSEISAEDVEEMMAQAKAEQRQEPEGDG 192
Cdd:COG0741    1 AAAAAAAAAALALAASAAAALALALLAAAAAAAALAAAAAALAAAAAAAAGAAAAAASAAAGGPALAAALAAADALAAFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 193 RRDILSFSVPMPESRASDKAEEFREDVEAEAERYDVDPALMLAVMHSESSFNPMARSHIPAYGLMQIVPESAgRDVAQRV 272
Cdd:COG0741   81 AIAALAAELLALAALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATA-RRLGLKL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 273 ygeQRLFSPDYLYNPDNNIRAGAVYLDILDSSYLsaiedpeSRLYAVISAYNTGAGNVARAFVDGTNVSaaaevindmsp 352
Cdd:COG0741  160 ---GLGPSPDDLFDPETNIRAGAAYLRELLDRFD-------GDLVLALAAYNAGPGRVRRWLRRNGDRD----------- 218

                        250       260       270
                 ....*....|....*....|....*....|.
gi 121588511 353 devyetlAENLPYEETRNYLVNVASRHQAYR 383
Cdd:COG0741  219 -------GEIIPYAETRNYVKKVLANYAIYR 242
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 214-375 4.20e-33

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 120.69  E-value: 4.20e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 214 EFREDVEAEAERYDVDPALMLAVMHSESSFNPMARSHIPAYGLMQIVPESAgRDVAQRvYGEQrLFSPDYLYNPDNNIRA 293
Cdd:cd16896    3 KYREYIEKYAKEYGVDPLLVAAVIKVESNFNPNAVSSKGAIGLMQIMPETA-EWIAEK-LGLE-DFSEDDLYDPETNIRL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 294 GAVYLdildsSYLsaIEDPESRLYAVISAYNTGAGNVARAFVDGTNvsaaaevindmspDEVYETLaENLPYEETRNYLV 373
Cdd:cd16896   80 GTWYL-----SYL--LKEFDGNLVLALAAYNAGPGNVDKWLKDGGW-------------SGDGKTL-DQIPFPETRHYVK 138


                 ..
gi 121588511 374 NV 375
Cdd:cd16896  139 KV 140
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 215-383 1.84e-30

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 114.11  E-value: 1.84e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 215 FREDVEAEAERYDVDPALMLAVMHSESSFNPMARSHIPAYGLMQIVPeSAGRDVAQRvYGEqRLFSPDYLYNPDNNIRAG 294
Cdd:cd13401    6 YRDLVERAAKKNGLDPALVYAIIRQESAFDPDAVSPAGALGLMQLMP-ATAKDVAKK-LGL-PYYSPRDLFDPEYNIRLG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 295 AVYLDILDSSYlsaiedPESRLYAvISAYNTGAGNVARAFVDGtnvsaaaeviNDMSPDEvyetLAENLPYEETRNYLVN 374
Cdd:cd13401   83 SAYLAELLDRF------DGNPVLA-LAAYNAGPGRVRRWLKRR----------GDLDPDL----WIETIPFSETRNYVKR 141


                 ....*....
gi 121588511 375 VASRHQAYR 383
Cdd:cd13401  142 VLENYVVYR 150
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
220-372 3.54e-28

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 109.67  E-value: 3.54e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 220 EAEAERYDVDPALMLAVMHSESSFNPMARSHIPAYGLMQIVPESAGRDVAQRV--YGEQrlfSPDYLYNPDNNIRAGAVY 297
Cdd:PRK15470  44 QKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSGRDVYRRMgwSGEP---TTSELKNPERNISMGAAY 120

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 121588511 298 LDILDSSYLSAIEDPESRLYAVISAYNTGAGNVARAFvdGTNVSAAAEVINDMSPDEVYETLAENLPYEETRNYL 372
Cdd:PRK15470 121 LNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTF--SSDRKKAISKINDLDADEFLEHVARNHPAPQAPRYI 193
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 221-334 9.22e-26

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 100.07  E-value: 9.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511  221 AEAERYDVDPALMLAVMHSESSFNPMARSHIPAYGLMQIVPESAGRdvaqrvYGEQRLFSPDYLYNPDNNIRAGAVYLDI 300
Cdd:pfam01464   3 KAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKR------LGLRVNPGVDDLFDPEKNIKAGTKYLKE 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 121588511  301 LDSSYLsaiedpeSRLYAVISAYNTGAGNVARAF 334
Cdd:pfam01464  77 LYKQYG-------GDLWLALAAYNAGPGRVRKWI 103
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 223-333 5.58e-22

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 91.44  E-value: 5.58e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 223 AERYDVDPALMLAVMHSESSFNPMARSHIPAYGLMQIVPEsagrdVAQRVYGEQRlfspdylYNPDNNIRAGAVYLDILD 302
Cdd:cd13403    5 AEKYGFDWRLLAAQAYQESRFNPNARSPAGARGLMQLMPS-----TARELGVNDR-------LDPEQNIHAGAKYLRYLR 72

                         90       100       110
                 ....*....|....*....|....*....|.
gi 121588511 303 SSYlSAIEDPESRLYAVISAYNTGAGNVARA 333
Cdd:cd13403   73 DRF-PPDIDEPDRLKFALAAYNAGPGHVRDA 102
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 230-380 6.35e-21

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 86.88  E-value: 6.35e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 230 PALMLAVMHSESSFNPMARSHIPAYGLMQIVPESAgRDVAQRvygeqrlfSPDYLYNPDNNIRAGAVYLDILdssylsaI 309
Cdd:cd00254    1 PALVLAVIRVESGFNPRAVSPAGARGLMQLMPGTA-RDLGRR--------GVDDLFDPEENIRAGARYLREL-------L 64

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 121588511 310 EDPESRLYAVISAYNTGAGNVARAFVdgtnvsaaaevindmspdevyetlAENLPYEETRNYLVNVASRHQ 380
Cdd:cd00254   65 DRFGGDLELALAAYNAGPGAVDRWGG------------------------GEVPPYKETRNYVQRVLAYYQ 111
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 206-333 8.69e-21

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 93.20  E-value: 8.69e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 206 SRASDKAEEFREDVEAEAERYDVDPALMLAVMHSESSFNPMARSHIPAYGLMQIVPESAGR-DVAQRvygeqrlfspdyl 284
Cdd:COG4623  255 RRIEGRLPPYDPLFEKYAEEYGLDWRLLAALAYQESHWNPRARSPTGARGLMQLMPATAKElGVDDR------------- 321

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 121588511 285 YNPDNNIRAGAVYLDILDSSYLSAIEDPEsRLYAVISAYNTGAGNVARA 333
Cdd:COG4623  322 LDPEQSIRAGAKYLRWLYDRFPEAIDEPD-RWWFALAAYNAGPGHVQDA 369
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 227-385 8.18e-12

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 66.62  E-value: 8.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 227 DVDPALMLAVMHSESSFNPMARSHIPAYGLMQIVPESAGRDVAQrvYGEQRLFSPDYLYNPDNNIRAGAVYLDILDSSYl 306
Cdd:PRK11619 491 GIPQSYAMAIARQESAWNPKARSPVGASGLMQIMPGTATHTVKM--FSIPGYSSSSQLLDPETNINIGTSYLEYVYQQF- 567

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 307 saiedPESRLYAViSAYNTGAGNVARAFVD-GTNVSAAAEVindmspdevyetlaENLPYEETRNYLVNVASRHQAYRDF 385
Cdd:PRK11619 568 -----GNNRILAS-AAYNAGPGRVRTWLGNsAGRIDAVAFV--------------ESIPFSETRGYVKNVLAYDAYYRYF 627
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 226-298 2.93e-08

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 51.38  E-value: 2.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 226 YDVDPALMLAVMHSESSFNPMARSHIP----AYGLMQI----VPEsagrdVAQRVYGEQRLfspdyLYNPDNNIRAGAVY 297
Cdd:cd13400    1 YGVPPRLLRAIAKVESGFNPNAINRNKngsyDIGLMQInsiwLPE-----LARYGITREEL-----LNDPCTNIYVGAWI 70


                 .
gi 121588511 298 L 298
Cdd:cd13400   71 L 71
LT_VirB1-like cd16892
VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up ...
 227-326 4.64e-08

VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up type IV secretion systems (T4SS). T4SS are macromolecular assemblies generally composed of VirB1-11 and VirD4 proteins, and are used by bacteria to transport material across their membranes. VirB1 acts as a lytic transglycosylase (LT), and is important with respect to piercing the peptidoglycan layer in the periplasm. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381613 [Multi-domain]  Cd Length: 143  Bit Score: 51.78  E-value: 4.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 227 DVDPALMLAVMHSESSFNPMA-------RSHIPA--------------------YGLMQIvpESA-----GRDVAQrvyg 274
Cdd:cd16892    8 GVHPETLAAIVQVESGGNPYAigvnggkLSRQPKtkaeaiatarqliaaghnfdVGLGQI--NSRnlarlGLTVED---- 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 121588511 275 eqrlfspdyLYNPDNNIRAGAvylDILDSSYLSAIE---DPESRLYAVISAYNTG 326
Cdd:cd16892   82 ---------VFDPCTNLKAGA---TILTECYARAKKtggDGQAALRAALSCYNTG 124
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 224-372 1.13e-06

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 47.13  E-value: 1.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 224 ERYDVdPALMLAVMHSESSFNPMARSHIPAYGLMQIVPESAgRDVAQRVYGE--QRlfspdylYNPDNNIRAGAVYLdil 301
Cdd:cd16894    2 LKEGL-PEELKYLALVESGFNPDAVSSAGAAGLWQFMPATA-REYGLRVDSWvdER-------RDPEKSTRAAARYL--- 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 121588511 302 dssylsaiedpeSRLYA-------VISAYNTGAGNVARAfvdgtnvsaaaevINDMSPDEVYETLAENLPyEETRNYL 372
Cdd:cd16894   70 ------------KDLYKrfgdwllALAAYNAGEGRVRRA-------------IKRAGTDKWEDYYRLYLP-AETRRYV 121
PRK10859 PRK10859
membrane-bound lytic murein transglycosylase MltF;
224-333 5.34e-05

membrane-bound lytic murein transglycosylase MltF;


Pssm-ID: 236778 [Multi-domain]  Cd Length: 482  Bit Score: 45.25  E-value: 5.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 224 ERY--DVDPALMLAVMHSESSFNPMARSHIPAYGLMQIVpesagRDVAQRVYGEQRLfspdylyNPDNNIRAGAVYLDIL 301
Cdd:PRK10859 295 EKYagELDWRLLAAIAYQESHWNPQATSPTGVRGLMMLT-----RNTAQSMGVTDRL-------DPEQSIRGGARYLQDL 362

                         90       100       110
                 ....*....|....*....|....*....|....
gi 121588511 302 DSSYLSAIEDPEsRLYAVISAYNTGAGNV--ARA 333
Cdd:PRK10859 363 MERLPESIPEPE-RIWFALAAYNIGYGHMldARR 395
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 226-333 2.24e-04

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 40.37  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121588511 226 YDVDPALMLAVMHSESSFNPMA-RSHIPAYGLMQIVPESAgRDVAqrVYGEQrlFSPDYLYNPDNNIRAGAvyldildsS 304
Cdd:cd13399    1 YGVPPGILAAILGVESGFGPNAgGSPAGAQGIAQFMPSTW-KAYG--VDGNG--DGKADPFNPEDAIASAA--------N 67

                         90       100       110
                 ....*....|....*....|....*....|....
gi 121588511 305 YLSAIEDPESRLYA-----VISAYNTGAGNVARA 333
Cdd:cd13399   68 YLCRHGWDLNAFLGednflALAAYNAGPGAYANA 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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