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Conserved domains on  [gi|1215229360|gb|ASK71201|]
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glucose/galactose MFS transporter [Shewanella bicestrii]

Protein Classification

sugar MFS transporter( domain architecture ID 13024430)

sugar major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of sugar substrates including glucose, galactose, mannose and fucose

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_FucP_like cd17394
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ...
 15-426 1.30e-113

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340952 [Multi-domain]  Cd Length: 401  Bit Score: 338.81  E-value: 1.30e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  15 MAIVAALFFILGFATWLNGSLMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMGIMMLAGLL 94
Cdd:cd17394     1 LALVTSLFFLWGFATNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  95 FIPAAKTQIFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAPLVFSALILDSFKDRIGT 174
Cdd:cd17394    81 FIPAASLRTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYLILSGIPSTATA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 175 T------LTQVQIDEMANSLVFPYLGMAIFIGVLALAVKKSPLPELSNEDEVAEHTdKGQIKAALSHPNLAFGVIALFVY 248
Cdd:cd17394   161 LaamsaaELQAYKTAELASVQLPYLGIALVLLLLAVLILLSKLPEIEAAEAEALGS-KGTLLRLLKNPHLRLGVLAIFFY 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 249 VAVEVIAGDTIGTFA----LSLGVEHYGVMTSYTMVCMVLGYTLGIILIPRfISQPTALMISAILGLLLTLAILFGDNHS 324
Cdd:cd17394   240 VGAEVAIWSFLINYLmeyiAGLTETSAATFVSYYWGGFMVGRFLGTALLKK-ISPKKLLAVFALLGLLLLLGAIFTGGMV 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 325 yaianallvpfggvalpdTLLFIAFLGLANAIVWPAVWPLALSGLGKLTSTGSALLIMGIAGGAFGPLFWGLMsSATDMG 404
Cdd:cd17394   319 ------------------ALYALVLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLVMAIVGGAVVPLIQGAV-ADDAAG 379

                         410       420
                  ....*....|....*....|..
gi 1215229360 405 QQGGYMVMLPCYLFILFYAVKG 426
Cdd:cd17394   380 LRIAFLVPLLCFAYILFYGLRG 401
 
Name Accession Description Interval E-value
MFS_FucP_like cd17394
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ...
 15-426 1.30e-113

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340952 [Multi-domain]  Cd Length: 401  Bit Score: 338.81  E-value: 1.30e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  15 MAIVAALFFILGFATWLNGSLMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMGIMMLAGLL 94
Cdd:cd17394     1 LALVTSLFFLWGFATNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  95 FIPAAKTQIFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAPLVFSALILDSFKDRIGT 174
Cdd:cd17394    81 FIPAASLRTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYLILSGIPSTATA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 175 T------LTQVQIDEMANSLVFPYLGMAIFIGVLALAVKKSPLPELSNEDEVAEHTdKGQIKAALSHPNLAFGVIALFVY 248
Cdd:cd17394   161 LaamsaaELQAYKTAELASVQLPYLGIALVLLLLAVLILLSKLPEIEAAEAEALGS-KGTLLRLLKNPHLRLGVLAIFFY 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 249 VAVEVIAGDTIGTFA----LSLGVEHYGVMTSYTMVCMVLGYTLGIILIPRfISQPTALMISAILGLLLTLAILFGDNHS 324
Cdd:cd17394   240 VGAEVAIWSFLINYLmeyiAGLTETSAATFVSYYWGGFMVGRFLGTALLKK-ISPKKLLAVFALLGLLLLLGAIFTGGMV 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 325 yaianallvpfggvalpdTLLFIAFLGLANAIVWPAVWPLALSGLGKLTSTGSALLIMGIAGGAFGPLFWGLMsSATDMG 404
Cdd:cd17394   319 ------------------ALYALVLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLVMAIVGGAVVPLIQGAV-ADDAAG 379

                         410       420
                  ....*....|....*....|..
gi 1215229360 405 QQGGYMVMLPCYLFILFYAVKG 426
Cdd:cd17394   380 LRIAFLVPLLCFAYILFYGLRG 401
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
7-432 1.81e-67

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 219.73  E-value: 1.81e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360   7 QQKSSFLPMAIVAALFFILGFATWLNGSLMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMG 86
Cdd:COG0738     2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  87 IMMLAGLLFipaAKTQIFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPeESAAARVSVMGILNKGAGVIAPLVFSALILD 166
Cdd:COG0738    82 LMALGLLLF---ALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 167 SFkdrigttltqvqidemANSLVFPYLGMAIFIGVLALAVKKSPLPELSNEDEVAEHTDKGqIKAALSHPNLAFGVIALF 246
Cdd:COG0738   158 GL----------------SLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAAS-LKSLLKNPRLLLGGLAIF 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 247 VYVAVEVIAGDTIGTFA---LSLGVEHYGVMTSYTMVCMVLGYTLGIILIpRFISQPTALMISAILGllltlailfgdnh 323
Cdd:COG0738   221 LYVGAEGAIGDWLPLYLkdvLGLSEATAALGLSLFWGGMTIGRFLGGFLL-KRFGPVRLLRLSALLA------------- 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 324 syAIANALLVPFGGVALpdTLLFIAFLGLANAIVWPAVWPLALSGLGKLTST-GSALLIMGIAGGAFGPLFWGLMSSATd 402
Cdd:COG0738   287 --AVGLLLALLAPGPWL--ALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAaVSAVLIMGIVGGAIGPPLIGFLADAF- 361

                         410       420       430
                  ....*....|....*....|....*....|
gi 1215229360 403 mGQQGGYMVMLPCYLFILFYAVKGHKMRHW 432
Cdd:COG0738   362 -GLRAAFLVPLVCYLLILLLALALKRKRRK 390
gluP TIGR01272
glucose/galactose transporter; This model describes the glucose/galactose transporter in ...
 95-422 2.23e-52

glucose/galactose transporter; This model describes the glucose/galactose transporter in bacteria. This belongs to the larger facilitator superfamily. Disruption of the loci leads to the total loss of glucose or galactose uptake in E.coli. Putative transporters in other bacterial species were isolated by functional complementation, which restored it functional activity. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273531 [Multi-domain]  Cd Length: 310  Bit Score: 178.17  E-value: 2.23e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  95 FIPAAKTQIFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAPLVFSALILDSFKDrigT 174
Cdd:TIGR01272   1 FGPAASQRYYVLFLGALFVLASGLTILQVAANPYVSILGPIETAASRLALTQAFNKLGTTVAPLFGGSLILSGAGD---L 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 175 TLTQVQIDEMANSLVFPYLGMAIFIGVLALAVKKSPLPELSNEDE-VAEHTDKGQIKAALSHPNLAFGVIALFVYVAVEV 253
Cdd:TIGR01272  78 SMQVATANAEAAKVHTPYLLLAGALAVLAIIFAFLPLPELQEADVaRVSSGDTTQKTSAFQFTHLVLGALGIFVYVGAEV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 254 IAGDTIGTF-----ALSLGVEHYGVMTSYTMVCMVLGYTLGIILIPrFISQPTALMISAILgllltlailfgdnhsyaia 328
Cdd:TIGR01272 158 SAGSFLVNFlsdphALGLPEDQAAHFTAYTWGGAMVGRFIGSAVMP-MISQGRYLAFNAFL------------------- 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 329 nALLVPFGGVALPD--TLLFIAFLGLANAIVWPAVWPLALSGLGKLTSTGSALLIMGIAGGAFGPLFWGLMSSATDMgqQ 406
Cdd:TIGR01272 218 -AVLLSIGAALTHGyvAMWFVLALGLFNSIMFPTIFSLALNALGRHTSQGSGILCLAIVGGAIVPLLQGSLADCLGI--Q 294

                         330
                  ....*....|....*.
gi 1215229360 407 GGYMVMLPCYLFILFY 422
Cdd:TIGR01272 295 LAFALPVPCYLYILFY 310
PRK10133 PRK10133
L-fucose:H+ symporter permease;
4-400 2.37e-31

L-fucose:H+ symporter permease;


Pssm-ID: 182260 [Multi-domain]  Cd Length: 438  Bit Score: 124.62  E-value: 2.37e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360   4 DKSQQKSSFLPMAIVAALFFILGFATWLNGSLMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMAL 83
Cdd:PRK10133   17 DAGQSRSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIIT 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  84 GMGIMMLAGLLFIPAAKTQIFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAPLVFSAL 163
Cdd:PRK10133   97 GLFLYALGAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSL 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 164 ILDSFKDR---IGTTLTQVQIDEMANSLVF----PYLGMAIFIGVLALAVKKSPLPELSNEDevaeHTDKGQIKAALSHP 236
Cdd:PRK10133  177 ILSNVPHQsqdVLDKMTPEQLSAYKHSLVLsvqtPYMIIVAIVLLVALLIMLTKFPALQSDN----HSDAKQGSFSASLS 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 237 NLA------FGVIALFVYVAveviAGDTIGTFALSLGVEHYGVMT--------SYTMVCMVLGYTLGIILIPRFISQpTA 302
Cdd:PRK10133  253 RLArirhwrWAVLAQFCYVG----AQTACWSYLIRYAVEEIPGMTagfaanylTGTMVCFFIGRFTGTWLISRFAPH-KV 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 303 LMISAILGLLLTLAILFGDNHsyaianallvpFGGVALPDTLLFIaflglanAIVWPAVWPLALSGLGKLTSTGSALLIM 382
Cdd:PRK10133  328 LAAYALIAMALCLISAFAGGH-----------VGLIALTLCSAFM-------SIQYPTIFSLGIKNLGQDTKYGSSFIVM 389

                         410
                  ....*....|....*...
gi 1215229360 383 GIAGGAFGPLFWGLMSSA 400
Cdd:PRK10133  390 TIIGGGIVTPVMGFVSDA 407
MFS_1 pfam07690
Major Facilitator Superfamily;
14-157 1.06e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 50.49  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  14 PMAIVAALFFILGFATWLNGSLMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMGIMMLAGL 93
Cdd:pfam07690 201 PVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAL 280

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1215229360  94 LFIPAAKTQIFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAP 157
Cdd:pfam07690 281 GLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_FucP_like cd17394
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ...
 15-426 1.30e-113

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340952 [Multi-domain]  Cd Length: 401  Bit Score: 338.81  E-value: 1.30e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  15 MAIVAALFFILGFATWLNGSLMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMGIMMLAGLL 94
Cdd:cd17394     1 LALVTSLFFLWGFATNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  95 FIPAAKTQIFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAPLVFSALILDSFKDRIGT 174
Cdd:cd17394    81 FIPAASLRTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYLILSGIPSTATA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 175 T------LTQVQIDEMANSLVFPYLGMAIFIGVLALAVKKSPLPELSNEDEVAEHTdKGQIKAALSHPNLAFGVIALFVY 248
Cdd:cd17394   161 LaamsaaELQAYKTAELASVQLPYLGIALVLLLLAVLILLSKLPEIEAAEAEALGS-KGTLLRLLKNPHLRLGVLAIFFY 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 249 VAVEVIAGDTIGTFA----LSLGVEHYGVMTSYTMVCMVLGYTLGIILIPRfISQPTALMISAILGLLLTLAILFGDNHS 324
Cdd:cd17394   240 VGAEVAIWSFLINYLmeyiAGLTETSAATFVSYYWGGFMVGRFLGTALLKK-ISPKKLLAVFALLGLLLLLGAIFTGGMV 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 325 yaianallvpfggvalpdTLLFIAFLGLANAIVWPAVWPLALSGLGKLTSTGSALLIMGIAGGAFGPLFWGLMsSATDMG 404
Cdd:cd17394   319 ------------------ALYALVLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLVMAIVGGAVVPLIQGAV-ADDAAG 379

                         410       420
                  ....*....|....*....|..
gi 1215229360 405 QQGGYMVMLPCYLFILFYAVKG 426
Cdd:cd17394   380 LRIAFLVPLLCFAYILFYGLRG 401
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
7-432 1.81e-67

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 219.73  E-value: 1.81e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360   7 QQKSSFLPMAIVAALFFILGFATWLNGSLMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMG 86
Cdd:COG0738     2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  87 IMMLAGLLFipaAKTQIFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPeESAAARVSVMGILNKGAGVIAPLVFSALILD 166
Cdd:COG0738    82 LMALGLLLF---ALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 167 SFkdrigttltqvqidemANSLVFPYLGMAIFIGVLALAVKKSPLPELSNEDEVAEHTDKGqIKAALSHPNLAFGVIALF 246
Cdd:COG0738   158 GL----------------SLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAAS-LKSLLKNPRLLLGGLAIF 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 247 VYVAVEVIAGDTIGTFA---LSLGVEHYGVMTSYTMVCMVLGYTLGIILIpRFISQPTALMISAILGllltlailfgdnh 323
Cdd:COG0738   221 LYVGAEGAIGDWLPLYLkdvLGLSEATAALGLSLFWGGMTIGRFLGGFLL-KRFGPVRLLRLSALLA------------- 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 324 syAIANALLVPFGGVALpdTLLFIAFLGLANAIVWPAVWPLALSGLGKLTST-GSALLIMGIAGGAFGPLFWGLMSSATd 402
Cdd:COG0738   287 --AVGLLLALLAPGPWL--ALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAaVSAVLIMGIVGGAIGPPLIGFLADAF- 361

                         410       420       430
                  ....*....|....*....|....*....|
gi 1215229360 403 mGQQGGYMVMLPCYLFILFYAVKGHKMRHW 432
Cdd:COG0738   362 -GLRAAFLVPLVCYLLILLLALALKRKRRK 390
gluP TIGR01272
glucose/galactose transporter; This model describes the glucose/galactose transporter in ...
 95-422 2.23e-52

glucose/galactose transporter; This model describes the glucose/galactose transporter in bacteria. This belongs to the larger facilitator superfamily. Disruption of the loci leads to the total loss of glucose or galactose uptake in E.coli. Putative transporters in other bacterial species were isolated by functional complementation, which restored it functional activity. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273531 [Multi-domain]  Cd Length: 310  Bit Score: 178.17  E-value: 2.23e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  95 FIPAAKTQIFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAPLVFSALILDSFKDrigT 174
Cdd:TIGR01272   1 FGPAASQRYYVLFLGALFVLASGLTILQVAANPYVSILGPIETAASRLALTQAFNKLGTTVAPLFGGSLILSGAGD---L 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 175 TLTQVQIDEMANSLVFPYLGMAIFIGVLALAVKKSPLPELSNEDE-VAEHTDKGQIKAALSHPNLAFGVIALFVYVAVEV 253
Cdd:TIGR01272  78 SMQVATANAEAAKVHTPYLLLAGALAVLAIIFAFLPLPELQEADVaRVSSGDTTQKTSAFQFTHLVLGALGIFVYVGAEV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 254 IAGDTIGTF-----ALSLGVEHYGVMTSYTMVCMVLGYTLGIILIPrFISQPTALMISAILgllltlailfgdnhsyaia 328
Cdd:TIGR01272 158 SAGSFLVNFlsdphALGLPEDQAAHFTAYTWGGAMVGRFIGSAVMP-MISQGRYLAFNAFL------------------- 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 329 nALLVPFGGVALPD--TLLFIAFLGLANAIVWPAVWPLALSGLGKLTSTGSALLIMGIAGGAFGPLFWGLMSSATDMgqQ 406
Cdd:TIGR01272 218 -AVLLSIGAALTHGyvAMWFVLALGLFNSIMFPTIFSLALNALGRHTSQGSGILCLAIVGGAIVPLLQGSLADCLGI--Q 294

                         330
                  ....*....|....*.
gi 1215229360 407 GGYMVMLPCYLFILFY 422
Cdd:TIGR01272 295 LAFALPVPCYLYILFY 310
fucP TIGR00885
L-fucose:H+ symporter permease; This family describes the L-fucose permease in bacteria. ...
 13-423 5.09e-32

L-fucose:H+ symporter permease; This family describes the L-fucose permease in bacteria. L-fucose(6-deoxy-L-galactose) is a monosaccharide found in glycoproteins and cell wall polysaccharides. L-fucose is used in bacteria through an inducible pathway mediated by atleast four enzymes: a permease, isomerase, kinase and an aldolase which are encoded by fucP, fucI, fucK, fucA respectively. The fuc genes belong to a regulon comprising of four linked operons: fucO, fucA, fucPIK and fucR. The positive regulator is encoded by fucR, whose protein responds to fuculose-1-phosphate, which acts as an effector. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 211614  Cd Length: 408  Bit Score: 125.74  E-value: 5.09e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  13 LPMAIVAALFFILGFATWLNGSLMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMGIMMLAG 92
Cdd:TIGR00885   3 IPFALITSLFALWGFANDITNPMVPQFQQAFTLTAFQAALVQSAFYGGYFIMAIPAAIFMKKLSYKAGILLGLFLYALGA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  93 LLFIPAAKTQIFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAPLVFSALI---LDSFK 169
Cdd:TIGR00885  83 FLFWPAAEIMNYTLFLVGLFILTAGLGFLETAANPYILVMGPESTATRRLNLAQSFNPFGSIIGMVVAQQLIlsnLPHQS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 170 DRIGTTLTQVQIDEMANSLVF----PYLGMAIFIGVLALAVKKSPLPELSNEDevaehTDKGQIKAALSH----PNLAFG 241
Cdd:TIGR00885 163 QDVLDKLSPEELSAIKHSDLAsvqtPYMIIGAVVLAVALLIMLTKMPALNHSD-----AKQISFSASLSRlariRHYREG 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 242 VIALFVYVAVEVIAGDTIGTFALSLGV-EHYGVMTSY---TMVCMVLGYTLGIILIPRFISQpTALMISAILGLLLTLAI 317
Cdd:TIGR00885 238 VIAQFFYVGVQIMCWTFIIQYAVRLIPgMTAGFAANYnigAMVIFFISRFIGTWLISYLAAH-KVLMAYAIIGMALCLGS 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 318 LFGDNHsyaianallvpFGGVALPDTLLFIaflglanAIVWPAVWPLALSGLGKLTSTGSALLIMGIAGGAFGPlfwGLM 397
Cdd:TIGR00885 317 IFAGGH-----------VGLYCLTLCSAFM-------SLMFPTIYGIALKGLGQDTKYGAAGLVMAIIGGGIVP---PLQ 375

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1215229360 398 SSATDMGQQGG-------YMVMLPCYLFILFYA 423
Cdd:TIGR00885 376 GFIIDMKEIAAapavntsFILPLLCFAVIFIYG 408
PRK10133 PRK10133
L-fucose:H+ symporter permease;
4-400 2.37e-31

L-fucose:H+ symporter permease;


Pssm-ID: 182260 [Multi-domain]  Cd Length: 438  Bit Score: 124.62  E-value: 2.37e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360   4 DKSQQKSSFLPMAIVAALFFILGFATWLNGSLMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMAL 83
Cdd:PRK10133   17 DAGQSRSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIIT 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  84 GMGIMMLAGLLFIPAAKTQIFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAPLVFSAL 163
Cdd:PRK10133   97 GLFLYALGAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSL 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 164 ILDSFKDR---IGTTLTQVQIDEMANSLVF----PYLGMAIFIGVLALAVKKSPLPELSNEDevaeHTDKGQIKAALSHP 236
Cdd:PRK10133  177 ILSNVPHQsqdVLDKMTPEQLSAYKHSLVLsvqtPYMIIVAIVLLVALLIMLTKFPALQSDN----HSDAKQGSFSASLS 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 237 NLA------FGVIALFVYVAveviAGDTIGTFALSLGVEHYGVMT--------SYTMVCMVLGYTLGIILIPRFISQpTA 302
Cdd:PRK10133  253 RLArirhwrWAVLAQFCYVG----AQTACWSYLIRYAVEEIPGMTagfaanylTGTMVCFFIGRFTGTWLISRFAPH-KV 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 303 LMISAILGLLLTLAILFGDNHsyaianallvpFGGVALPDTLLFIaflglanAIVWPAVWPLALSGLGKLTSTGSALLIM 382
Cdd:PRK10133  328 LAAYALIAMALCLISAFAGGH-----------VGLIALTLCSAFM-------SIQYPTIFSLGIKNLGQDTKYGSSFIVM 389

                         410
                  ....*....|....*...
gi 1215229360 383 GIAGGAFGPLFWGLMSSA 400
Cdd:PRK10133  390 TIIGGGIVTPVMGFVSDA 407
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 18-404 3.58e-13

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 70.43  E-value: 3.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  18 VAALFFILGFATWLNGSLMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMGIMMLAGLLFIP 97
Cdd:cd17333     1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  98 AAKtqiFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPeESAAARVSVMGILNKGAGVIAPLVFSALILDSfkdrigttlt 177
Cdd:cd17333    81 TPS---IYLFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLLTSE---------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 178 qvqidemaNSLVFPYLGMAI--FIGVLALAVKKSPLPELSNEDEVAEHTDKGQIKAALSHPNLAFGVIALFVYVAVEVIA 255
Cdd:cd17333   147 --------LSWSWAYLIIGLiyLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAF 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 256 GDTIGTFALSLGVEHYGVMT---SYTMVCMVLGYTLGIILIpRFISQPTALMISAILGLLLTLAILFGDNhsyaianall 332
Cdd:cd17333   219 SSWVPSYLVEKKHVSDGLAGyllSGFWVGITIGRLLGGPIS-RRIKPHTLLVLSGSGALLGLLILLLAPT---------- 287

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1215229360 333 vPFGGVALpdtllfIAFLGLANAIVWPAVWPLALSGLGKL-TSTGSALLIMGIAGGAFGPLFWGLMSSATDMG 404
Cdd:cd17333   288 -LVVGLVA------TALLGLFMAALFPTILSLGISNLPYAkGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQ 353
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
6-388 1.59e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 59.22  E-value: 1.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360   6 SQQKSSFLPMAIVAALFFILGFATWLNGSLMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGM 85
Cdd:COG2814     3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  86 GIMMLAGLLfipAAKTQIFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAPLVfSALIL 165
Cdd:COG2814    83 LLFALGSLL---CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLL-GGLLA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 166 DSFkdrigttltqvqidemanSLVFPYLGMAIFIGVLALAVKKSplpeLSNEDEVAEHTDKGQIKAALSHPNLAFGVIAL 245
Cdd:COG2814   159 DLF------------------GWRWVFLVNAVLALLALLLLLRL----LPESRPAARARLRGSLRELLRRPRLLLLLLLA 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 246 FVYVAVEVIAGDTIGTFA---LSLGVEHYGVMTSYTMVCMVLGYTLGIILIPRFISQPTALMISAIlgllltlailfgdn 322
Cdd:COG2814   217 FLLGFGFFALFTYLPLYLqevLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLL-------------- 282

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1215229360 323 hsYAIANALLVPFGGVALpdTLLFIAFLGLANAIVWPAVWPLALSGLGK-LTSTGSALLIMGIAGGA 388
Cdd:COG2814   283 --LALGLLLLALAGSLWL--LLLALFLLGFGFGLLFPLLQALVAELAPPeARGRASGLYNSAFFLGG 345
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 18-422 1.71e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 55.90  E-value: 1.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  18 VAALFFILGFATWLNGSLMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMGIMMLAGLLFIP 97
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  98 AAktqIFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAPLVFSALILDSFKDrigttlt 177
Cdd:cd06174    81 AP---SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFG------- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 178 qvqideMANSLVFPYLGMAIFIGVLALAVKKSPLPELSNEDEVAEHTDKGQIKAALSHPNLAFGVIALFVYVAVEVIAGD 257
Cdd:cd06174   151 ------WRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFST 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 258 TIGTFALSLG---VEHYGVMTSYTMVCMVLGYTLGIILIPRFISQPTALMISAILGLLLTLAILFGDNHSYAIANALLVP 334
Cdd:cd06174   225 LLPLFLLDLGglsVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLG 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 335 FGgvalpdtllfiafLGLANAIVWpaVWPLALSGLGKLTSTGSALLIMGIAGGAFGPLFWGLMSSATDMGQQGGYMVMLP 414
Cdd:cd06174   305 FG-------------LGGLLPLSF--ALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVL 369


                  ....*...
gi 1215229360 415 CYLFILFY 422
Cdd:cd06174   370 LLLAAILL 377
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 10-206 3.08e-08

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 55.26  E-value: 3.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  10 SSFLPMAIVAALFFILGFatwlngslmpYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMGIMM 89
Cdd:cd17321   176 AAFLLGAALGGLLFLLPL----------YLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTA 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  90 LAGLLFIPAAKTQIFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAPLVFSALILDSFK 169
Cdd:cd17321   246 VGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLS 325

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1215229360 170 DRIGTTLTQVQIDEMANSLVFPYLGMAIFIGVLALAV 206
Cdd:cd17321   326 ANLGDSGVAALLSAAAAAFAAGFHLAFLVAAALALLA 362
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
14-206 1.11e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 53.75  E-value: 1.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  14 PMAIVAALFFILGFATWLNGSLMPY-LKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMGIMMLAG 92
Cdd:COG2211   229 PFLLLLLAYLLFFLALALVAALLLYyFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  93 LLFIPAAKTQIfGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARV-------SVMGILNKGAGVIAPLVFSALIl 165
Cdd:COG2211   309 LLLFFLGPGNL-WLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRrreglyfGIFTFAIKLGQALAGALAGLLL- 386

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1215229360 166 dsfkDRIGTTLTQVQIDEMANSLVFPYLGMAIFIGVLALAV 206
Cdd:COG2211   387 ----ALFGYVAGAAQSPSALTGIRLLFFLLPAVLLLLAALL 423
MFS_1 pfam07690
Major Facilitator Superfamily;
14-157 1.06e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 50.49  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  14 PMAIVAALFFILGFATWLNGSLMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMGIMMLAGL 93
Cdd:pfam07690 201 PVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAL 280

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1215229360  94 LFIPAAKTQIFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAP 157
Cdd:pfam07690 281 GLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
15-421 1.07e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 50.25  E-value: 1.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  15 MAIVAALFFILGFATWLNGSLMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMGIMMLAGLL 94
Cdd:COG2271    12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  95 FipaAKTQIFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAPLVFSALIldsfkdrigt 174
Cdd:COG2271    92 F---GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLL---------- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 175 tltqvqidemansLVFPYLGMAIFIGVLALAVkksplpelsnedevaehtdkgqikaalshpnLAFGVIALFVYVAVEVI 254
Cdd:COG2271   159 -------------AAFGWRAAFLILGLPGLLL-------------------------------ALLRFWLLALAYFLVYF 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 255 AGDTIGTFALSLGVEHYGV-------MTSYTMVCMVLGYTLGIILIPRFISQPTALMISAILGLlltlailfgdnhsyAI 327
Cdd:COG2271   195 ALYGFLTWLPTYLVEVRGLslaqaglLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLA--------------AL 260

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 328 ANALLVPFGGVALpdTLLFIAFLGLANAIVWPAVWPLALSGLGK-LTSTGSALL-IMGIAGGAFGPLFWGLMSSATdmGQ 405
Cdd:COG2271   261 ALLLLALLPSPAL--AIALLFLAGFGLGGAFGLLWALAAELFPKkARGTASGLVnTFGFLGGALGPLLVGYLLDAT--GY 336

                         410
                  ....*....|....*.
gi 1215229360 406 QGGYMVMLPCYLFILF 421
Cdd:COG2271   337 QAAFLLLAALALLAAL 352
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
12-164 1.69e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.79  E-value: 1.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  12 FLPMAIVAALFFILGFATWLNGSLMP-YLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVG--YKNGMALGMGIM 88
Cdd:COG2271   179 LLRFWLLALAYFLVYFALYGFLTWLPtYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLA 258

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1215229360  89 MLAGLLFIPAAKTQIFGLFLCaqlVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAPLVFSALI 164
Cdd:COG2271   259 ALALLLLALLPSPALAIALLF---LAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL 331
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 18-424 3.54e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 45.64  E-value: 3.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  18 VAALFFILGFATWLNGSLMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMGIMMLAGLLFIP 97
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  98 AaktQIFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNkGAGVIAPLVFSALILDSFkdrigttlt 177
Cdd:cd17325    81 A---TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAI-GLGFLIGPLLGGLLADAL--------- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 178 qvqidemanSLVFPYLGMAIFI---GVLALAVKKSPLPELSNEDEVAEHTDKGQIKAALSHPNLAFGVIALFVYVAVEVI 254
Cdd:cd17325   148 ---------GYRAPFLVCAALAllaLVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGAL 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 255 AGdtigtfALSLGVEHYGVMTSYTmvcmvLGYTLGIILIPRFISQPTALMISAILGLLLTLAILFGdnhSYAIANALLVP 334
Cdd:cd17325   219 EP------FLPLYAAELGGLSPAQ-----IGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLL---LSAVALLLLPL 284

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 335 FGGVALpdTLLFIAFLGLANAIVWPAVWPLaLSGLGKLTSTGSALLIMGIA---GGAFGPLFWGLMSSAtdmgqQGGYMV 411
Cdd:cd17325   285 ATSFWL--LLLLLALLGLGLGLVFPATLAL-LADIVPPEGRGTAMGLFNTAfslGMVLGPLLGGFLYDA-----FGFATP 356

                         410
                  ....*....|...
gi 1215229360 412 MLPCYLFILFYAV 424
Cdd:cd17325   357 FLAAAALLLLAAV 369
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
11-156 3.76e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 45.35  E-value: 3.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  11 SFLPMAIVAALFFILGFATWLNGSLmpYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMGIMML 90
Cdd:COG2814   208 RLLLLLLLAFLLGFGFFALFTYLPL--YLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1215229360  91 AGLLFipaAKTQIFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIA 156
Cdd:COG2814   286 GLLLL---ALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 17-163 8.76e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 44.51  E-value: 8.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  17 IVAALFFILGFATwLNGSLMPYLKQiLQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMGIMMLAGLLFI 96
Cdd:cd17489     2 LLANFFFFLSFYL-LLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1215229360  97 PAAKtqiFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAPLVFSAL 163
Cdd:cd17489    80 LATS---VALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFL 143
MFS_1 pfam07690
Major Facilitator Superfamily;
18-336 8.97e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 44.33  E-value: 8.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  18 VAALFFILGFATWLNGSLMP-YLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMGIMMLAGLLFI 96
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  97 PAAKtqiFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAPLVFSALIldsfkDRIGTtl 176
Cdd:pfam07690  81 FASS---LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-----SLFGW-- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 177 tqvqidemanSLVFPYLGMAIFIGVLALAVKKSPLPELSNEDEVAEHTDKGQIKAALSHPNLAFGVIALFVYVAVEVIAG 256
Cdd:pfam07690 151 ----------RAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLL 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360 257 DTIGTFALSLGVEHYGVMTSYTMVCMVLGYTLGII--LIPRFISQPTALMISAILGLLLTLAILFGDNHSYAIANALLVP 334
Cdd:pfam07690 221 TYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLgrLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLL 300


                  ..
gi 1215229360 335 FG 336
Cdd:pfam07690 301 LG 302
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 35-126 4.76e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 42.18  E-value: 4.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  35 LMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMGIMMLAGLLFIPAAKTQIFGLFLCAQLVM 114
Cdd:cd17503   201 LPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIR 280

                          90
                  ....*....|..
gi 1215229360 115 GTGQTLLQTAVN 126
Cdd:cd17503   281 GLGMGLVFMPLN 292
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
5-140 9.97e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 41.01  E-value: 9.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360   5 KSQQKSSFLPMAIVAALFFILGFATWLNGSLMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALG 84
Cdd:COG2807    10 RSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLA 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1215229360  85 MGIMMLAGLLFipAAKTQIFGLFLCAqLVMGTGQTLLQTAVNPYVVRLGPEESAAA 140
Cdd:COG2807    90 LLLLAAGLLLR--SLAPSVALLLAGT-ALIGAGIAVGNVLLPGLIKRWFPDRVGLM 142
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 12-163 1.48e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 40.63  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  12 FLPMAIVAALFFILGFATWLNGSLMpyLKQILQLNPFQASLILFSFYIAVTFTALPSAWVI-RKVGYKNGMALGMgIMML 90
Cdd:cd17474   200 LLTFLVSAFLYFFLYFAFLTYLPFL--LELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLkKRFGARRILVIGL-LLYA 276

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1215229360  91 AGLLFIPAAKTQifGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAPLVFSAL 163
Cdd:cd17474   277 LSLLLLGFVPSL--ALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLL 347
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 17-165 2.86e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 39.48  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  17 IVAALFFILGFATWLN----GSLMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALgmgIMMLAG 92
Cdd:cd17319     3 RIIPLLFLAYVINYLDrvniSVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAV---SMLLWS 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1215229360  93 LLFIPAAKTQIFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAPLVFSALIL 165
Cdd:cd17319    80 LFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLL 152
TerL_ATPase pfam03354
Terminase large subunit, ATPase domain; Terminase large subunit (TerL) from bacteriophages and ...
 75-211 3.23e-03

Terminase large subunit, ATPase domain; Terminase large subunit (TerL) from bacteriophages and evolutionarily related viruses, is an important component of the DNA packing machinery and comprises an ATPase domain, which powers DNA translocation and a nuclease domain that cuts concatemeric DNA. TerL forms pentamers in which the ATPase domains form a ring distal to the capsid. This is the ATPase domain which contains a C-terminal subdomain that sits above the ATPase active site, called the "Lid subdomain" with reference to analogous lid subdomains found in other ATPases. It contains a hydrophobic patch (Trp and Tyr residues) that mediates critical interactions in the interface between adjacent ATPase subunits and assists the positioning of the arginine finger residue that catalyzes ATP hydrolysis. This entry also includes bacterial proteins of unknown function.


Pssm-ID: 460895 [Multi-domain]  Cd Length: 178  Bit Score: 38.45  E-value: 3.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  75 VGYKNGMALGMGIMMLAGLLFIPAAKTQIFglflCAQLVMGTGQTLLQTAVNpyVVRLGPEESAAARVSVMGILNKG--- 151
Cdd:pfam03354  28 VGRKNGKSILDVMIALIELLLFPKPNSQIA----LAATTKDQAEKIFKKFKN--QVKLNKEQILVKDNSILKSMRKGiei 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1215229360 152 ---AGVIAPLVFSALILDsfkdriGTTLTQVQIDEMANslvFPYLGMAIFIgVLALAVKKSPL 211
Cdd:pfam03354 102 sivDGVIKCLSSNEDTLD------GGRPQLVIIDEFGA---FKDNEPLITI-RQGMRKRANPG 154
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 57-164 3.31e-03

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 39.37  E-value: 3.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  57 FYIAVTFTALPSA----WVIRKVGYKNGMALGMGIMMLAGLL-FIPAAKTQIFGLFLCAQLVMGTGQTLLQTavnpYVVR 131
Cdd:COG2270   279 FGLLVQIVAALGAllfgRLDDRIGPKRVILVSLVIWIVVCLAaYFLTTALAFWILGLLIGLVMGGIQALSRS----LLAR 354

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1215229360 132 LGPEESAAARVSVMGILNKGAGVIAPLVFSALI 164
Cdd:COG2270   355 LIPPGREAEFFGLYALSGKAASFLGPLLFGLVT 387
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 13-158 7.26e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 38.30  E-value: 7.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  13 LPMAIVAALFFILGFATWLNgSLMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMGIMMLAG 92
Cdd:cd17324   200 LRLAYLITFLLFGGFFALYT-YLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALL 278

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1215229360  93 LLFIPAAKTQIFGLFLcaqLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAPL 158
Cdd:cd17324   279 LLTLLGPSPLLLLVGL---VLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAAL 341
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 17-168 9.08e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 38.35  E-value: 9.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  17 IVAALFFILGFATwLNGSLMPYLKQILqLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMGIMMLAGLLFI 96
Cdd:cd17332   227 LLAYLLYFLAFNI-VNTVLVYYFKYVL-GGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLF 304

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1215229360  97 PAAKTQIFGLFLCAQL--VMGTGQTLLQTAVNPYVVRLGPEESAAAR----VSVMGILNKGAGVIApLVFSALILDSF 168
Cdd:cd17332   305 FLPPGNLVLILVLAVLagIGYGGANLLPWAMLADVIDYGELKTGKRRegifYSVMTFFRKLGLALA-GALVGLILSLA 381
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 13-164 9.19e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 37.98  E-value: 9.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1215229360  13 LPMAIVAALFFILGFATWLNgsLMPYLKQILQLNPFQASLILFSFYIAVTFTALPSAWVIRKVGYKNGMALGMGIMmlaG 92
Cdd:cd06173   211 RLLLLALALFALLGGALTVL--LPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL---G 285

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1215229360  93 LLFIPAAKTQIFGLFLCAQLVMGTGQTLLQTAVNPYVVRLGPEESAAARVSVMGILNKGAGVIAPLVFSALI 164
Cdd:cd06173   286 LALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA 357
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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