NCBI Conserved Domain Search

NCBI

3D Macromolecular Structures

Conserved Domains

Conserved domains on [gi|1212989074|ref|NP_001340094|]

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zinc finger MYM-type protein 2 isoform 4 [Homo sapiens]

Protein Classification

heavy metal translocating P-type ATPase( domain architecture ID 10534316)

heavy metal translocating P-type ATPase is an integral membrane transporter that generates and maintains electrochemical gradients across cellular membranes by translocating heavy metals, and is distinguished from other transport ATPases (F-, V-, and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

462-502

4.12e-06

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

:

Pssm-ID: 428958 Cd Length: 40 Bit Score: 44.67 E-value: 4.12e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1212989074  462 LIMNCCEQCGEYLPSKGAGNnVLVIDGQQKRFCCQSCVSEY 502
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVI-VLQNDGSVGQFCSQSCLDSY 40

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

634-671

8.68e-06

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

:

Pssm-ID: 428958 Cd Length: 40 Bit Score: 43.51 E-value: 8.68e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1212989074  634 DIQLKCNYCKNSFCSKPE--ILEWENKVHQFCSKTCSDDY 671
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTviVLQNDGSVGQFCSQSCLDSY 40

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

531-570

3.05e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

:

Pssm-ID: 428958 Cd Length: 40 Bit Score: 41.97 E-value: 3.05e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1212989074  531 GKLTTCTGCRTQCRFFDMTQCIGPNGYMEPYCSTACMNSH 570
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVIVLQNDGSVGQFCSQSCLDSY 40

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

722-758

6.25e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

:

Pssm-ID: 428958 Cd Length: 40 Bit Score: 41.20 E-value: 6.25e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1212989074  722 LRCVTCNYCSQLCKKGATK---ELDGVVRDFCSEDCCKKF 758
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVivlQNDGSVGQFCSQSCLDSY 40

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

764-799

2.55e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

:

Pssm-ID: 428958 Cd Length: 40 Bit Score: 39.66 E-value: 2.55e-04

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1212989074  764 KAARCDCCKSQGTLKE---RVQWRGEMKHFCDQHCLLRF 799
Cdd:pfam06467    2 VKATCWFCKKLIKNKPtviVLQNDGSVGQFCSQSCLDSY 40

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

368-409

3.78e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

:

Pssm-ID: 428958 Cd Length: 40 Bit Score: 38.89 E-value: 3.78e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1212989074  368 APKKLCVMCKKDITTMKGtiVAQVDSSESFQEFCSTSCLSLY 409
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPT--VIVLQNDGSVGQFCSQSCLDSY 40

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

327-363

1.01e-03

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

:

Pssm-ID: 428958 Cd Length: 40 Bit Score: 37.74 E-value: 1.01e-03

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1212989074  327 VKVTCANCKKPLQKGQTAY--QRKGSAHLFCSTTCLSSF 363
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

420-456

1.14e-03

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

:

Pssm-ID: 428958 Cd Length: 40 Bit Score: 37.74 E-value: 1.14e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1212989074  420 LNKSRCTICGKLTEIRHE---VSFKNMTHKLCSDHCFNRY 456
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40

Name

Accession

Description

Interval

E-value

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

462-502

4.12e-06

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

Pssm-ID: 428958 Cd Length: 40 Bit Score: 44.67 E-value: 4.12e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1212989074  462 LIMNCCEQCGEYLPSKGAGNnVLVIDGQQKRFCCQSCVSEY 502
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVI-VLQNDGSVGQFCSQSCLDSY 40

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

634-671

8.68e-06

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

Pssm-ID: 428958 Cd Length: 40 Bit Score: 43.51 E-value: 8.68e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1212989074  634 DIQLKCNYCKNSFCSKPE--ILEWENKVHQFCSKTCSDDY 671
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTviVLQNDGSVGQFCSQSCLDSY 40

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

531-570

3.05e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

Pssm-ID: 428958 Cd Length: 40 Bit Score: 41.97 E-value: 3.05e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1212989074  531 GKLTTCTGCRTQCRFFDMTQCIGPNGYMEPYCSTACMNSH 570
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVIVLQNDGSVGQFCSQSCLDSY 40

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

722-758

6.25e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

Pssm-ID: 428958 Cd Length: 40 Bit Score: 41.20 E-value: 6.25e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1212989074  722 LRCVTCNYCSQLCKKGATK---ELDGVVRDFCSEDCCKKF 758
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVivlQNDGSVGQFCSQSCLDSY 40

TRASH

metallochaperone-like domain;

467-504

6.78e-05

metallochaperone-like domain;

Pssm-ID: 214799 Cd Length: 39 Bit Score: 41.21 E-value: 6.78e-05

                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1212989074   467 CEQCGEYLPSKGAGNNVlVIDGQQKRFCCQSCVSEYKQ 504
Cdd:smart00746    1 CSFCGKDIYNPGTGIMV-VNDGKVYYFCSSKCLSKFKK 37

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

764-799

2.55e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

Pssm-ID: 428958 Cd Length: 40 Bit Score: 39.66 E-value: 2.55e-04

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1212989074  764 KAARCDCCKSQGTLKE---RVQWRGEMKHFCDQHCLLRF 799
Cdd:pfam06467    2 VKATCWFCKKLIKNKPtviVLQNDGSVGQFCSQSCLDSY 40

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

368-409

3.78e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

Pssm-ID: 428958 Cd Length: 40 Bit Score: 38.89 E-value: 3.78e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1212989074  368 APKKLCVMCKKDITTMKGtiVAQVDSSESFQEFCSTSCLSLY 409
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPT--VIVLQNDGSVGQFCSQSCLDSY 40

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

327-363

1.01e-03

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

Pssm-ID: 428958 Cd Length: 40 Bit Score: 37.74 E-value: 1.01e-03

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1212989074  327 VKVTCANCKKPLQKGQTAY--QRKGSAHLFCSTTCLSSF 363
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

420-456

1.14e-03

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

Pssm-ID: 428958 Cd Length: 40 Bit Score: 37.74 E-value: 1.14e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1212989074  420 LNKSRCTICGKLTEIRHE---VSFKNMTHKLCSDHCFNRY 456
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40

TRASH

metallochaperone-like domain;

331-367

1.32e-03

metallochaperone-like domain;

Pssm-ID: 214799 Cd Length: 39 Bit Score: 37.36 E-value: 1.32e-03

                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1212989074   331 CANCKKPLQKGQTA--YQRKGSAHLFCSTTCLSSFSHKP 367
Cdd:smart00746    1 CSFCGKDIYNPGTGimVVNDGKVYYFCSSKCLSKFKKKR 39

TRASH

metallochaperone-like domain;

727-759

1.98e-03

metallochaperone-like domain;

Pssm-ID: 214799 Cd Length: 39 Bit Score: 36.97 E-value: 1.98e-03

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1212989074   727 CNYCSQLCKKGATKEL---DGVVRDFCSEDCCKKFQ 759
Cdd:smart00746    1 CSFCGKDIYNPGTGIMvvnDGKVYYFCSSKCLSKFK 36

TRASH

metallochaperone-like domain;

639-674

6.71e-03

metallochaperone-like domain;

Pssm-ID: 214799 Cd Length: 39 Bit Score: 35.43 E-value: 6.71e-03

                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1212989074   639 CNYCKNSFCSK--PEILEWENKVHQFCSKTCSDDYKKL 674
Cdd:smart00746    1 CSFCGKDIYNPgtGIMVVNDGKVYYFCSSKCLSKFKKK 38

Name

Accession

Description

Interval

E-value

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

462-502

4.12e-06

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

Pssm-ID: 428958 Cd Length: 40 Bit Score: 44.67 E-value: 4.12e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1212989074  462 LIMNCCEQCGEYLPSKGAGNnVLVIDGQQKRFCCQSCVSEY 502
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVI-VLQNDGSVGQFCSQSCLDSY 40

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

634-671

8.68e-06

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

Pssm-ID: 428958 Cd Length: 40 Bit Score: 43.51 E-value: 8.68e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1212989074  634 DIQLKCNYCKNSFCSKPE--ILEWENKVHQFCSKTCSDDY 671
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTviVLQNDGSVGQFCSQSCLDSY 40

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

531-570

3.05e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

Pssm-ID: 428958 Cd Length: 40 Bit Score: 41.97 E-value: 3.05e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1212989074  531 GKLTTCTGCRTQCRFFDMTQCIGPNGYMEPYCSTACMNSH 570
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVIVLQNDGSVGQFCSQSCLDSY 40

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

722-758

6.25e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

Pssm-ID: 428958 Cd Length: 40 Bit Score: 41.20 E-value: 6.25e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1212989074  722 LRCVTCNYCSQLCKKGATK---ELDGVVRDFCSEDCCKKF 758
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVivlQNDGSVGQFCSQSCLDSY 40

TRASH

metallochaperone-like domain;

467-504

6.78e-05

metallochaperone-like domain;

Pssm-ID: 214799 Cd Length: 39 Bit Score: 41.21 E-value: 6.78e-05

                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1212989074   467 CEQCGEYLPSKGAGNNVlVIDGQQKRFCCQSCVSEYKQ 504
Cdd:smart00746    1 CSFCGKDIYNPGTGIMV-VNDGKVYYFCSSKCLSKFKK 37

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

764-799

2.55e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

Pssm-ID: 428958 Cd Length: 40 Bit Score: 39.66 E-value: 2.55e-04

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1212989074  764 KAARCDCCKSQGTLKE---RVQWRGEMKHFCDQHCLLRF 799
Cdd:pfam06467    2 VKATCWFCKKLIKNKPtviVLQNDGSVGQFCSQSCLDSY 40

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

368-409

3.78e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

Pssm-ID: 428958 Cd Length: 40 Bit Score: 38.89 E-value: 3.78e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1212989074  368 APKKLCVMCKKDITTMKGtiVAQVDSSESFQEFCSTSCLSLY 409
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPT--VIVLQNDGSVGQFCSQSCLDSY 40

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

327-363

1.01e-03

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

Pssm-ID: 428958 Cd Length: 40 Bit Score: 37.74 E-value: 1.01e-03

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1212989074  327 VKVTCANCKKPLQKGQTAY--QRKGSAHLFCSTTCLSSF 363
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40

Arc_trans_TRASH

Archaeal TRASH domain; This region is found in the C-terminus of a number of archaeal ...

639-673

1.10e-03

Archaeal TRASH domain; This region is found in the C-terminus of a number of archaeal transcriptional regulators. It is thought to function as a metal-sensing regulatory module.

Pssm-ID: 285580 Cd Length: 37 Bit Score: 37.84 E-value: 1.10e-03

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1212989074  639 CNYCKNSFCSKPEILEWENKVHQFCSKTCSDDYKK 673
Cdd:pfam08394    1 CDYCGKEIVGEPITYKLKNKVYYFCCPTCLSQLKK 35

zf-FCS

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...

420-456

1.14e-03

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.

Pssm-ID: 428958 Cd Length: 40 Bit Score: 37.74 E-value: 1.14e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1212989074  420 LNKSRCTICGKLTEIRHE---VSFKNMTHKLCSDHCFNRY 456
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40

TRASH

metallochaperone-like domain;

331-367

1.32e-03

metallochaperone-like domain;

Pssm-ID: 214799 Cd Length: 39 Bit Score: 37.36 E-value: 1.32e-03

                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1212989074   331 CANCKKPLQKGQTA--YQRKGSAHLFCSTTCLSSFSHKP 367
Cdd:smart00746    1 CSFCGKDIYNPGTGimVVNDGKVYYFCSSKCLSKFKKKR 39

TRASH

metallochaperone-like domain;

727-759

1.98e-03

metallochaperone-like domain;

Pssm-ID: 214799 Cd Length: 39 Bit Score: 36.97 E-value: 1.98e-03

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1212989074   727 CNYCSQLCKKGATKEL---DGVVRDFCSEDCCKKFQ 759
Cdd:smart00746    1 CSFCGKDIYNPGTGIMvvnDGKVYYFCSSKCLSKFK 36

TRASH

metallochaperone-like domain;

639-674

6.71e-03

metallochaperone-like domain;

Pssm-ID: 214799 Cd Length: 39 Bit Score: 35.43 E-value: 6.71e-03

                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1212989074   639 CNYCKNSFCSK--PEILEWENKVHQFCSKTCSDDYKKL 674
Cdd:smart00746    1 CSFCGKDIYNPgtGIMVVNDGKVYYFCSSKCLSKFKKK 38

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01

References:

Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

Functional characterization of the conserved domain architecture found on the query. Click here to see more details.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options