|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
20-411 |
6.59e-62 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 204.77 E-value: 6.59e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 20 IWILAGGRLLSELGTGFTLFYAPIFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDspIWGRRKTLLLSAVFSAIG 99
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLAD--RFGRKPVMLAGLLLRALG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 100 STVLTATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGgnFRWLF 179
Cdd:cd17329 79 FALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS--FRLLF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 180 AIDATSFVIFFAVIWNAIRETsQLSLGEKKHHLGWSGWRILLQDHILWVYVLVNIMFTTYISQLHSTLPIYLQRVvvsdg 259
Cdd:cd17329 157 LAAAVLFLLAALVLLFLLPET-RPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEI----- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 260 GRLNEGIIAGLFAVHLLMAIVVQLPVAKMLRNLSHPQTLSVSAIIWSGGFAAVWWSGwaksGIWISGIALAIFAIALVSY 339
Cdd:cd17329 231 LGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFAN----TLAVLILAMIVLTLGEMLV 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1210186094 340 TPSAAAFVSEIAPVERRGIYLSVNSLCWAVGYFIGPSLGGWAMDQTSnvISIYWLGLAATTPIAIAILTYLQ 411
Cdd:cd17329 307 FPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG--PGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
28-412 |
1.16e-32 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 126.54 E-value: 1.16e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 28 LLSELGTGFTLFYAPIFfVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDspIWGRRKTLLLSAVFSAIGSTVLTATF 107
Cdd:cd17325 6 FLDMLGYGIIIPILPLY-AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSD--RFGRKRLLLLGLLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 108 DFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGnFRWLFAIDATSFV 187
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCAALAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 188 IFFAVIWNAIRET-SQLSLGEKKHHLGWSGWRILLQDHILWVYVLVNIMFTTYISQLHSTLPIYLQRVvvsdgGRLNEGI 266
Cdd:cd17325 162 LALVLALLLLPEPrPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAEL-----GGLSPAQ 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 267 IAGLFAVHLLMAIVVQLPVAKMLRNLSHPQTLSVSAIIWSGGFAAVWWSgwakSGIWISGIALAIFAIALVSYTPSAAAF 346
Cdd:cd17325 237 IGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA----TSFWLLLLLLALLGLGLGLVFPATLAL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1210186094 347 VSEIAPVERRGIYLSVNSLCWAVGYFIGPSLGGWAMDQTSNVISIYWLGLAAttpIAIAILTYLQR 412
Cdd:cd17325 313 LADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALL---LLAAVLFLLLR 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
18-410 |
5.63e-31 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 123.47 E-value: 5.63e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 18 SQIWILAGGRLLSELGTGFTLFYAPIFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDS--PIWGRRKT-LLLSAV 94
Cdd:COG2211 10 KEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRtrTRWGRRRPwILIGAI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 95 FSAIGSTVL------TATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRR-EAYAITRLADNLGLGMGIILAGW 167
Cdd:COG2211 90 PLALSFVLLftapdlSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERtRLSSWRFAFAGLGGLLASVLPPP 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 168 LVSAGG-----NFRWLFAIDATSFVIFFAVIWNAIRETSQlslGEKKHHLGWSGWRILLQDHILWVYVLVNIMFTTYISQ 242
Cdd:COG2211 170 LVAAFGgdaalGYRLTALIFAVLGLLAFLLTFFGTKERPV---PEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALAL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 243 LHSTLPIYLQRVVvsdggRLNEGIIAGLFAVHLLMAIVVQLPVAKMLRNLSHPQTLSVSAIIWSGGFAAVWWSGWakSGI 322
Cdd:COG2211 247 VAALLLYYFKYVL-----GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGP--GNL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 323 WISGIALAIFAIALVSYTPSAAAFVSEIAPVE-------RRGIYLSVNSLCWAVGYFIGPSLGGWAMD---------QTS 386
Cdd:COG2211 320 WLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgrrREGLYFGIFTFAIKLGQALAGALAGLLLAlfgyvagaaQSP 399
|
410 420
....*....|....*....|....
gi 1210186094 387 NVISIYWLGLAAtTPIAIAILTYL 410
Cdd:COG2211 400 SALTGIRLLFFL-LPAVLLLLAAL 422
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
20-370 |
6.76e-30 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 118.54 E-value: 6.76e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 20 IWILAGGRLLSELGTGFTLFYAPiFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDspIWGRRKTLLLSAVFSAIG 99
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD--RFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 100 STVLTATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGnFRWLF 179
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 180 AIDATSFVIFFAVIWNAIRETsqlslGEKKHHLGWSGWRILLQDHILWVYVLVNIMFTTYISQLHSTLPIYLQRVVvsdg 259
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPES-----RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL---- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 260 gRLNEGIIAGLFAVHLLMAIVVQLPVAKMLRNLSHPQTLSVSAIIWSGGFAAVWWSGwaksGIWISGIALAIFAIALVSY 339
Cdd:COG2814 239 -GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG----SLWLLLLALFLLGFGFGLL 313
|
330 340 350
....*....|....*....|....*....|.
gi 1210186094 340 TPSAAAFVSEIAPVERRGIYLSVNSLCWAVG 370
Cdd:COG2814 314 FPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
23-375 |
8.67e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 107.12 E-value: 8.67e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 23 LAGGRLLSELGTGFTLFYAPIFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDspIWGRRKTLLLSAVFSAIGSTV 102
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD--RFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 103 LTATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGnFRWLFAID 182
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 183 ATSFVIFFAVIW--NAIRETSQLSLGEKKHHLGWSGWRILLQDHILWvYVLVNIMFTTYISQLHSTLPIYLQRVvvsdgg 260
Cdd:pfam07690 158 AILSLLAAVLLLlpRPPPESKRPKPAEEARLSLIVAWKALLRDPVLW-LLLALLLFGFAFFGLLTYLPLYQEVL------ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 261 RLNEGIIAGLFAVHLLMAIVVQLPVAKMLRNLSHPQTLSVSAIIWSGGFAAVWWSGWAKSGIWIsGIALAIFAIALVSYT 340
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWL-LLALLLLGFGFGLVF 309
|
330 340 350
....*....|....*....|....*....|....*
gi 1210186094 341 PSAAAFVSEIAPVERRGIYLSVNSLCWAVGYFIGP 375
Cdd:pfam07690 310 PALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
21-411 |
1.95e-21 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 94.99 E-value: 1.95e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 21 WILAGGRLLSELGTGFTLFYAPIFfVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDspIWGRRKTLLLSAVFSAIGS 100
Cdd:cd06173 2 RLLWLAQLLSALGDWIFTVALPWL-VLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLAD--RFDRRRLLILADLLRALLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 101 TVLTATFDF-----VTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGnF 175
Cdd:cd06173 79 AVLALLALLgslslWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLG-P 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 176 RWLFAIDATSFVIFFAVIWnAIRETSQLSLGEKKHHLG---WSGWRILLQDHILWVYVLVNIMFTTYISQLHSTLPIYLQ 252
Cdd:cd06173 158 GGAFAINALSFLLSALLLL-FIRRPPPAAPGESSSLLLrdlREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 253 RVVVSDGGRLneGIIAGLFAVHLLMAIVVqlpVAKMLRNLSHPQTLSVSAIIWSGGFAAVWWSgwakSGIWISGIALAIF 332
Cdd:cd06173 237 EVLGGGAAGY--GLLLAAFGVGALLGALL---LGRLSKRRRRGRLLLIGALLLGLALLVLGLS----PSLWLLLAALFLL 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1210186094 333 AIALVSYTPSAAAFVSEIAPVERRGIYLSVNSLCWAVGYFIGPSLGGWAMDQTSNVISIYWLGLAAttpIAIAILTYLQ 411
Cdd:cd06173 308 GLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALL---LLAALLLLLL 383
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
49-398 |
8.02e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 90.56 E-value: 8.02e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 49 VGLSATSVGIALGTASISGIAGRVCGGLWTDSpiWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWP 128
Cdd:cd06174 26 FGLSASQLGLLFALFSLGYALLQPLAGLLADR--FGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 129 ATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSA-GGNFRWLFAIDATSFVIFFAVIWNAIRETSQLSLGE 207
Cdd:cd06174 104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAK 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 208 KK---HHLGWSGWRILLQDHILWVYVLVNIMFTTYISQLHSTLPIYLQRVVVSDGgrLNEGIIAGLFAVHLLMAIVVQLP 284
Cdd:cd06174 184 NEeasSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSV--AVAGLLLSLFGLAGALGSLLLGL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 285 VAKmlRNLSHPQTLSVSAIIWSGGFAAVWWSgwakSGIWISGIALAIFAIALVSYTPSAAAFVSEIAPVERRGIYLSVNS 364
Cdd:cd06174 262 LSD--RLIGRKPLLLIGLLLMALGLALLLLA----PSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLN 335
|
330 340 350
....*....|....*....|....*....|....
gi 1210186094 365 LCWAVGYFIGPSLGGWAMDQTSNVISIYWLGLAA 398
Cdd:cd06174 336 TFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVL 369
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
43-415 |
1.56e-17 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 83.78 E-value: 1.56e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 43 IFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDspIWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFG 122
Cdd:COG2223 29 PPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVD--RFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 123 AGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGnFRWLFAIDATSFVIFFAVIWNAIRETSQ 202
Cdd:COG2223 107 GGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG-WRNAFLILGILLLVVAVLAWLFLRDPPA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 203 LSLGEKKHhlGWSGWRILLQDHILWVYVLVNIMFTTYISQLHSTLPIYLQrvvvsDGGRLNEGIIAGLFAVHLLMAIVVQ 282
Cdd:COG2223 186 GAAAAAKA--SLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLV-----DQFGLSAATAGLLAALFALLGALGR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 283 LPVAKMLRNLSHPQTLSVSAIIWSGGFAAVWWSGwakSGIWISGIALAIFAIALVSYTPSAAAFVSEIAPVERRGIYLSV 362
Cdd:COG2223 259 PLGGWLSDRIGGRRVLLIVFALMALGLLLLALAL---GSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGL 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1210186094 363 NSLCWAVGYFIGPSLGGWAMDQTSNVISIYWLGLAATTPIAIAILTYLQRIRN 415
Cdd:COG2223 336 VGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRR 388
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-194 |
8.62e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 81.47 E-value: 8.62e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 17 DSQIWILAGGRLLSELGTGFTLFYAPIFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDSpiWGRRKTLLLSAVFS 96
Cdd:cd17325 198 DRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDR--IGRKPLILIGLLLS 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 97 AIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGnFR 176
Cdd:cd17325 276 AVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FA 354
|
170
....*....|....*...
gi 1210186094 177 WLFAIDATSFVIFFAVIW 194
Cdd:cd17325 355 TPFLAAAALLLLAAVLFL 372
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
44-407 |
2.41e-16 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 79.89 E-value: 2.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 44 FFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDspIWGRRKTLLLSA-VFSAIGSTVLTATFDFVTLVIGNIIGGFG 122
Cdd:cd17370 24 LFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSD--RTGKRKPLVILGyGLSALAKPLLALAGSWQLVLLLRILERLG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 123 AGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVS-AGGNFRWLFAIDATSFVIFFAVIWNAIRETS 201
Cdd:cd17370 102 KGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYlLGGNYRTIFLLAAIPALLALLILLFVVKEYP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 202 QLSLGEKKHHlgWSGWRILlqDHILWVYVLVNIMFTtyISQLHSTLPIY-LQRVVVSDggrlneGIIAGLFAVHLLMAIV 280
Cdd:cd17370 182 RPPKLRKKSK--KTSLKKL--PKAFWLYLLAVALFA--LGNFSFAFLILrAQELGLSA------ALIPLLYALFNLVYAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 281 VQLPVAKMLRNLSHPQTLSVSAIIWSGGFAAVWWSgwakSGIWISGIALAIFAIALVSYTPSAAAFVSEIAPVERRGIYL 360
Cdd:cd17370 250 AAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALG----SSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAY 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1210186094 361 SVNSLCWAVGYFIGPSLGGWAMDQTSNVISIYWLGLAATtpIAIAIL 407
Cdd:cd17370 326 GLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLAL--IALLLL 370
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
59-412 |
1.55e-14 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 74.53 E-value: 1.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 59 ALGTASISGIAGRVCGglwtdspIWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLT 138
Cdd:cd17473 45 ALFIALFAPLAGWLAD-------RFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYF 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 139 TPQNRREAYAITRLADNLGLGMGIILAGWLvsAGGNFRWLFAIDATSFVIFFAVIWnAIRETSQLSLGEKKHHLgwSGWR 218
Cdd:cd17473 118 EGEERAKMLGLQSAAMSLGGVVFLLLGGAL--AEIGWRAPFLVYLLALPVLILVLL-FLPEPARKSKSAASPGA--ATAA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 219 ILLQDHILWVYVLVNIMFTTYisqlhSTLPIYLQRVVVSDGGrLNEGIIAGLFAVHLLMAIVVQLPVAKMLRNLSHPQTL 298
Cdd:cd17473 193 ALPWKRVLPIYFLAFLAMLLF-----YVIPIQLPFLLQERGG-GSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 299 SVSAIIWSGGFAAVWWSgwakSGIWISGIALAIFAIALVSYTPSAAAFVSEIAPVERRGIYLSVNSLCWAVGYFIGPSLG 378
Cdd:cd17473 267 AIGFALMALGFLLLALA----SGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVL 342
|
330 340 350
....*....|....*....|....*....|....
gi 1210186094 379 GWAMDQTSNVISIYwlGLAATTPIAIAILTYLQR 412
Cdd:cd17473 343 GPLVNLTGGLSGAF--LILGVLALVLAIVLLLLR 374
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
50-407 |
4.18e-14 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 72.98 E-value: 4.18e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 50 GLSATSVGIALGTASISGIAGRVCGGLWTDSpiWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPA 129
Cdd:COG2271 41 GLSAAQLGLLASAFFLGYALGQIPAGLLADR--FGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 130 TEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGnFRWLFAIdaTSFVIFFAVIWNAIRetsqlslgekk 209
Cdd:COG2271 119 ALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-WRAAFLI--LGLPGLLLALLRFWL----------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 210 hhlgwsgwrillqdhILWVYVLVNIMFTTYISQLhstlPIYLQrvvvsDGGRLNEGIIAGLFAVHLLMAIVVQLPVAKML 289
Cdd:COG2271 185 ---------------LALAYFLVYFALYGFLTWL----PTYLV-----EVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 290 RNLSHPQTLSVsaIIWSGGFAAVWWSGWAKSGIWISGIALAIFAIALVSYTPSAAAFVSEIAPVERRGIYLSVNSLCWAV 369
Cdd:COG2271 241 DRLGRRRKLVL--AIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFL 318
|
330 340 350
....*....|....*....|....*....|....*...
gi 1210186094 370 GYFIGPSLGGWAMDQTSNVISIYWLGLAATTPIAIAIL 407
Cdd:COG2271 319 GGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
83-408 |
8.59e-14 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 72.22 E-value: 8.59e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 83 WGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGI 162
Cdd:cd17474 61 FGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGP 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 163 ILAGWLVSAGgnFRWLFAIDATSFVIFFAVIWNAIRET-------SQLSLGEKKHHLGWSGWRIllqdhILWVYVLVNIM 235
Cdd:cd17474 141 LLGGLLAAIS--WRYPFFLLAALIPVAFLAILFLLPEPkekakssSATKLRDLKKALRGRGLLT-----FLVSAFLYFFL 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 236 FTTYIsqlhSTLPIYLQRVVVsdggrLNEGIIAGLFAVHLLMAIVVQLPVAKMLRN-LSHPQTLSVSAIIWSGGFAAVWW 314
Cdd:cd17474 214 YFAFL----TYLPFLLELLYG-----ISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGF 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 315 SgwakSGIWISGIALAIFAIALVSYTPSAAAFVSEIAPVERRGIYLSVNSLCWAVGYFIGPSLGGWAMDQTSNVISIYWL 394
Cdd:cd17474 285 V----PSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVG 360
|
330
....*....|....
gi 1210186094 395 GLAATTPIAIAILT 408
Cdd:cd17474 361 AAIALAAAVLLALL 374
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-202 |
1.40e-13 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 71.44 E-value: 1.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 19 QIWILAGGRLLSELGTGFTLFYAPIFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDSPIWGRRKTLLLSAVFSAI 98
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 99 GSTVLTATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGnFRWL 178
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAA 339
|
170 180
....*....|....*....|....
gi 1210186094 179 FAIDATSFVIFFAVIWNAIRETSQ 202
Cdd:COG2271 340 FLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
50-410 |
1.83e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 71.43 E-value: 1.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 50 GLSATSVGIALGTASISGIAGRVCGGLWTDSpiWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPA 129
Cdd:cd17324 30 GVSVAQAGLLVSAYALGYALGALLLGPLSDR--IERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 130 TEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGnFRWLFAIDATSFVIFFAVIWNAIRetsQLSLGEKK 209
Cdd:cd17324 108 AAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAAFLAIAVLALLAALLLWRLLP---SLPPKKPG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 210 HHLGWSGWRILLQDHILWVYVLVNIMFTTYISQLHSTLPIYLQRVVVSDGGRlnegiIAGLFAVHLLMAIVVQLPVAKML 289
Cdd:cd17324 184 SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSA-----IIGLLLLFGVAGVVGSPLAGRLA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 290 RNLSHPQTlsvsaIIWSGGFAAVWWSGWAKSGIWISGIALAIFAIALVSYTPSAA-AFVSEIAPvERRGIYLSVNSLCWA 368
Cdd:cd17324 259 DRGGRRAL-----LIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALqTRVLRLAP-EARGLASSLYLAAYN 332
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1210186094 369 VGYFIGPSLGGWAMDQTSnVISIYWLGLAAttpIAIAILTYL 410
Cdd:cd17324 333 LGGALGAALGGLVLDHGG-WAGVGWVGAAL---LLLALLLAL 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
36-410 |
4.33e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 69.93 E-value: 4.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 36 FTLFYAPI----FFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDSpiWGRRKTLLLSAVFSAIGSTVLTATFDFVT 111
Cdd:cd17489 9 FLSFYLLLpvlpLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDR--FGRKRLLLIGLLIFALATLLYLLATSVAL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 112 LVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGnFRWLFAIDATSFVIFFA 191
Cdd:cd17489 87 LLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLFIVAAVLALLALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 192 VIWNaIRETSQLSlgEKKHHLGWSGWRILLQDHILWVYVLVNIMFTTYiSQLHSTLPIYLQRVVVSDGGRlnegiiagLF 271
Cdd:cd17489 166 LVFL-VKDPPPVA--AEEAEAGTRAFRRLVEKKVLPPALILFLASIAY-GAISTFLPLYAAERGISNAGL--------FF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 272 AVHLLMAIVVQLPVAKMLRNLSHPQTLSVSAIIWSGGFAAVWWSGwaksGIWISGIALAIFAIALVSYTPSAAAFVSEIA 351
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAG----SPWMLLLAAVLYGLGFGLLFPALQALAVDLV 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1210186094 352 PVERRGIYLSVNSLCWAVGYFIGPSLGGWAMDqtsnVISIYWLGLAATTPIAIAILTYL 410
Cdd:cd17489 310 PPHRRGAANGTFFIFFDLGIGLGGLLLGLVAE----LFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
44-407 |
4.23e-11 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 63.75 E-value: 4.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 44 FFVTKVGLSATSVGIALGTASISGIAGRVCGGLW-TDSPIWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFG 122
Cdd:cd17330 21 FYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWgRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLT 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 123 AGlYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGnFRWLFAIDATSFVIFFAVIWNAIRETSQ 202
Cdd:cd17330 101 GG-NVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYG-YALPFLVAAALALLNLVLVLFFLPPLRR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 203 LslgekkhhlgwsgwrillqdhiLWVYVLVNIMFTTYisqlHSTLPIYLqrvvvSDGGRLNEGIIAGLFAVHLLMAIVVQ 282
Cdd:cd17330 179 L----------------------LLVYFLIALAFAGL----ESVFSLFL-----KDRFGFSPSQIGLLLALVGIAGILAQ 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 283 LPVAKML-RNLSHPQTLSVSAIIWSGGFAAVwwsGWAKSGIWIsGIALAIFAIALVSYTPSAAAFVSEIAPVERRGIYLS 361
Cdd:cd17330 228 LLLIPRLaKRLGERKLLRLGLLLAIIGLLLL---PFASSVPLL-VLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQG 303
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1210186094 362 VNSLCWAVGYFIGPSLGGWAMDQTSNVISIYWLGLAATTPIAIAIL 407
Cdd:cd17330 304 IIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
28-405 |
1.04e-09 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 59.49 E-value: 1.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 28 LLSELGTGFTLFYAPIFFvTKVGLSATSVGIALGTASIsgiaGRVCGGLWTDSPI--WGRRKTLLLSAVFSAIGSTVLTA 105
Cdd:cd17477 6 ALLGLGSGLLLPLLSLRL-EREGVSTALIGLVASAYYL----GILLGSPLVPRLIrrVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 106 TFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGNFRWLFAIDATS 185
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 186 FVIFFAVIWNAIRETSQLSlgekkhhlgWSGWRILLQdhILWVYVLVNIMFTTYISQLHSTLPIYLQRVVVSdggrlnEG 265
Cdd:cd17477 161 ALVPLLLTRRAAPEIEEAE---------SISLRRLLR--IAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLS------VA 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 266 IIAGLFAVHLLMAIVVQLPVAKMLRNLSHPQTLSVSAIIWSGGFAAVWwsgWAKSGIWISGIALAIFAIALVSYTPSAAA 345
Cdd:cd17477 224 QAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLP---LVPGLPLALLVLLFLWGGAAGPLYTLALA 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 346 FVSEIAPVERRGIYLSVNSLCWAVGYFIGPSLGGWAMDQTSNVISIYWLGLAATTPIAIA 405
Cdd:cd17477 301 LAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
75-200 |
1.13e-09 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 56.50 E-value: 1.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 75 GLWTDspIWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLAD 154
Cdd:TIGR00880 19 GLLTD--RFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGI 96
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1210186094 155 NLGLGMGIILAGWLVSAGGnFRWLFAIDATSFVIFFAVIWNAIRET 200
Cdd:TIGR00880 97 ALGPLLGPPLGGVLAQFLG-WRAPFLFLAILALAAFILLAFLLPET 141
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
50-415 |
2.56e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 58.71 E-value: 2.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 50 GLSATSVGIALGTASISGIAGRVCGGLWTDspIWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPA 129
Cdd:COG0738 39 GLSDAQAGLLLFAFFLGYLLASLPAGRLID--RFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 130 TEAVVADLtTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGNFRWLFAIDATSFVIFFAVIWNAIRETSQLSLGEKK 209
Cdd:COG0738 117 ANPYVAAL-GPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEE 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 210 HHLGWSGWRILLQDHILWVYVLvnIMFTTYISQ--LHSTLPIYLQrvvvsDGGRLNEGIIAGLFAVHLLMAIVVQLPVAK 287
Cdd:COG0738 196 AAGSAASLKSLLKNPRLLLGGL--AIFLYVGAEgaIGDWLPLYLK-----DVLGLSEATAALGLSLFWGGMTIGRFLGGF 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 288 MLRNLSHPQTLSVSAIIWSGGFAAVWWSgwakSGIWISGIALAIFAIALVSYTPSAAAFVSEIAPvERRGIYLSVNSLCW 367
Cdd:COG0738 269 LLKRFGPVRLLRLSALLAAVGLLLALLA----PGPWLALIGLALVGLGLSLMFPTIFSLALDGLG-KRTAAAVSAVLIMG 343
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1210186094 368 AVGYFIGPSLGGWAMDQTSNVISiYWLGLAATTPIAIAILtYLQRIRN 415
Cdd:COG0738 344 IVGGAIGPPLIGFLADAFGLRAA-FLVPLVCYLLILLLAL-ALKRKRR 389
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
50-401 |
4.63e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 57.61 E-value: 4.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 50 GLSATSVGIALGTASISGIAGRVCGGLWTDSpiWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAglYWPA 129
Cdd:cd17472 28 GATPTLIGLALGIYGLTQAIFQIPFGLLSDR--IGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGA--ISSV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 130 TEAVVADLTTPQNRREAYAITRLADNLGLGMGIILaGWLVSAGGNFRWLFAIDATSFVIFFAVIWNAIRETSQLSLGEKK 209
Cdd:cd17472 104 VMALLADLTREENRTKAMALIGASIGIAFAISMVL-GPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEK 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 210 HhlgWSGWRILLQDHILWVYVLVNIMFTTYISQLHSTLPIYLQRVVVSDGgrlNEGIIaglFAVHLLMAIVVQLPVAKML 289
Cdd:cd17472 183 E---KKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKG---QLWKV---YLPAILIGFILMVPFVIYA 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 290 RNLSHPQTLSVSAIIWSG-GFAAVWWSgwAKSGIWISgIALAIFAIALVSYTPSAAAFVSEIAPVERRGIYLSVNSLCWA 368
Cdd:cd17472 254 EKKGKMKQVFVSSILLIAvGFLLLLFA--ATSLWLLI-IGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQF 330
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1210186094 369 VGYFIGPSLGGW--------AMDQTSNVISIYWLGLAATTP 401
Cdd:cd17472 331 LGSFLGGALGGLlwgllgysSVFLTILILALLWLLVSFLLP 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-157 |
6.45e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 57.29 E-value: 6.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 3 QQPKSRGGLSIPQFDSQIWILAGGRLLSELGTGFTLFYAPIFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDSpi 82
Cdd:COG2814 192 ARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR-- 269
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1210186094 83 WGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLG 157
Cdd:COG2814 270 FGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
39-408 |
1.91e-08 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 56.07 E-value: 1.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 39 FYAPIFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDS--PIWGRRKT-LLLSAVFSAIGSTVLTATFDFVT---- 111
Cdd:cd17332 20 TYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRtrSRWGRFRPwLLWGAIPLALLFVLLFTTPDGSGtgkl 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 112 --LVIGNIIGGFGAGLYWPATEAVVADLTT-PQNRREAYAITRLADNLGLGMGIILAGWLVSAGGN------FRWLFAID 182
Cdd:cd17332 100 iyALITYILLDLLYTLVNIPYTALIPELTDdPEERTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGgnasrgYFLTALII 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 183 ATSFVIFFAVIWNAIRETSQLSLGEKKHHLGWSGWRILLQDHILWVYVLVNIMFTTYISQLHSTLPIYLQRVvvsDGGRL 262
Cdd:cd17332 180 GIIGIILLLICFFGTRERVVPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYV---LGGRA 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 263 NEGIIAGLFAVHLLMAIVVQLPVakmLRNLSHPQTLSVSAIIWSGGFAAVWWSGWAKSGIWISGIALAIFAIALVSYTPS 342
Cdd:cd17332 257 ELVLLLLLILSGALLALLPWPPL---KKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPW 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 343 A-AAFVSEIA----PVERRGIYLSVNSLCWAVGYFIGPSLGGW----------AMDQTSNVISIYWLgLAATTPIAIAIL 407
Cdd:cd17332 334 AmLADVIDYGelktGKRREGIFYSVMTFFRKLGLALAGALVGLilslagyvanAAAQSASALNGIRL-LIAVLPAVLLLL 412
|
.
gi 1210186094 408 T 408
Cdd:cd17332 413 A 413
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
19-194 |
2.40e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 55.27 E-value: 2.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 19 QIWILAGGRLLSELGTGFTLFYAPIFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDSPIWGRRKTLLLSAVFSAI 98
Cdd:cd17319 180 QVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 99 GSTVLTATFDFVTLVIGNI-IGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGNFRW 177
Cdd:cd17319 260 VGLLLAYLTTSPVVAVILLsLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTA 339
|
170
....*....|....*..
gi 1210186094 178 LFAIDATSFVIFFAVIW 194
Cdd:cd17319 340 AFLFLAAVALLAALLVL 356
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
50-304 |
1.03e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 53.28 E-value: 1.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 50 GLSATSVGIALGTASISGIAGRVCGGLWTDspIWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPA 129
Cdd:COG0477 45 GASSAQLGWIVSAYLLGRAIGLLLFGRLGD--RYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 130 TEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGnFRWLFAIDATSFVIFFAVIWNaIRETSQLSLGEKK 209
Cdd:COG0477 123 ALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG-WRWIFLINAPLGLLALVLRLR-LPESRGLLLALLA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 210 HHLGWSGWRILLQDHILWVYVLVNIMFTTYISQLHSTLPIYLQRVVVSDGGRLNEGIIAGLFAVHLLMAIVVQLPVAKML 289
Cdd:COG0477 201 LALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLL 280
|
250
....*....|....*
gi 1210186094 290 RNLSHPQTLSVSAII 304
Cdd:COG0477 281 LLLLLLLLLLLALLL 295
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
50-194 |
1.05e-07 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 53.51 E-value: 1.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 50 GLSATSVGIALGTASISGIAGRVCGGLWTDspIWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPA 129
Cdd:cd17362 35 NLSSLQSGLVVSGSLLGALLGSLVAGALID--RLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHA 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1210186094 130 TEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGNFRWLFAIDATSFVIFFAVIW 194
Cdd:cd17362 113 APVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVGGWRYMYGLAAPPALLLGIGMW 177
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
44-406 |
4.26e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 51.79 E-value: 4.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 44 FFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDspIWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGA 123
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLAD--RKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 124 GLYWPATeAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGNFRWLFAIdATSFVIFFAVIWnairETSQL 203
Cdd:cd17478 99 AAFHPEG-ARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILL-IIPGLAVALLLL----RLRPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 204 SLGEKKHHLGWSGWRILLQDHILWVYVLVNIMF--TTYISQLHSTLPIYLQRVVVSdggRLNEGIIAGLFavhLLMAIVV 281
Cdd:cd17478 173 KKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFlrSWVLSSLTTFLPFYLVQRGYS---LVFAGLLLSLF---LFAGAIG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 282 QLPVAKMLRNLSHPQTLSVSAIIWSGGFAAVWWsgwakSGIWISGIALAIFAIALVSYTPSAAAFVSEIAPvERRGIyls 361
Cdd:cd17478 247 TLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLL-----TPGIWSYILLVLAGFLLFASFPVTVVLAQELLP-GNVGL--- 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1210186094 362 VNSLCWAVGYFIG---PSLGGWAMDQTSNVISIYWLGLAATTPIAIAI 406
Cdd:cd17478 318 ASGLMMGLSFGLGgigAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
82-416 |
5.93e-07 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 51.67 E-value: 5.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 82 IWGRRKTLLLSAVFSAIGSTVLTAT-----FDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNL 156
Cdd:pfam05977 71 NFDRRKIMLAGQLLLALVSTLLTLLaglglLSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNI 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 157 GLGMGIILAGWLVSAGGNFrWLFAIDATSFVIFFAVIWNAIRETSQLSLGEKKHHLGWS-GWRILLQDHILWVYVLVNIM 235
Cdd:pfam05977 151 ARSVGPALGGVLLAAFGPA-FTFALNALSYFAVIAALWRWKRAAPASPLPRERIFGAVRaGLRFTAMSRELRSVLVRAFA 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 236 FTTYISQLHSTLPIYLQRVVvsDGGRLNEGIIAGLFAVHllmAIVVQLPVAKMLRNLSHPQTLSVSAIiwsgGFAAVWWS 315
Cdd:pfam05977 230 FGLSASAVWALLPLVARDLL--DGDAIFYGILLGAVGVG---AILGALSLPRLRERLGSDRLVLLASV----VTALVLLS 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 316 GWAKSGIWISGIALAIFAIALVSYTPSAAAFVSEIAPVERRGIYLSVnslcWAVGYFIGPSLGGWAMDQTSNVISIYW-L 394
Cdd:pfam05977 301 LALAPNLWLAIPVLLLGGAAWITALTTLNVAVQLSVPRWVRGRALAV----YQTVFFGGMAAGSWLWGAVAEALSVTGaL 376
|
330 340
....*....|....*....|..
gi 1210186094 395 GLAATTPIAIAILTYLQRIRNM 416
Cdd:pfam05977 377 LGAAAALLAGAAAGLRFRLPEG 398
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
44-407 |
1.32e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 49.93 E-value: 1.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 44 FFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDspIWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGA 123
Cdd:cd17475 21 FLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLD--RFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 124 GLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGnFRWLFAIDATSFVIFFAVIWNAIRETSQL 203
Cdd:cd17475 99 GSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYG-WRAAFVVAGLVSILAAVLFWLFYREPPAA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 204 SLGEKKHHLGWSGWRILLQDHILWVYVLVNIMFTTYISQLHSTLPIYLQrvvvsDGGRLNEGIIAGLFAVHLLMAIVVQL 283
Cdd:cd17475 178 SAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLH-----DHLGLSVVAAGALLAVAQLGGALGRI 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 284 PVAKM---LRNLSHPQTLSVSAIIWSGGFAAVWWSGWAkSGIWISGIALAIFAIALVSYTPSAAAFVSEIAPVERRGIYL 360
Cdd:cd17475 253 GLGRVsdrVFGGRRRPVLVITAAIAAAALLVLSLLSPG-TPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTAL 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1210186094 361 SV-NSLCWaVGYFIGPSLGGWAMDQTSNvISIYWLGLAATTPIAIAIL 407
Cdd:cd17475 332 GLaNTINF-IGIAIGPPLFGLLVDATHS-YAPAWLALALLLVLAALLL 377
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
50-410 |
1.47e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 49.88 E-value: 1.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 50 GLSATSVGIALGTASISGIAGRVCGGLWTDspIWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPA 129
Cdd:cd17319 34 GLSPTQYGLIASAFFLGYALFQVPGGWLLD--RFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 130 TEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGnFRWLFAIDAtSFVIFFAVIWnairetsqlslgekk 209
Cdd:cd17319 112 AIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFG-WRWAFIIEG-LLGLLLAVLW--------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 210 hhlgwsgWRILLQdhiLWVYVLVNIMFTTYISQLHSTLPIYLQRVVVSDGgrLNEGIIAGLFAVHLLMAIVVQLPVAKML 289
Cdd:cd17319 175 -------WFYLRQ---VWGLALGYFGINYALYGLLTWLPTYLKQARGFSL--KQVGLLAAIPFLAGAIGMILGGRLSDRL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 290 RNLSHPQTLSVSAIIWSGGFAAVWWSgwakSGIWISGIALAIFAIALVSYTPSAAAFVSEIAPVERRGIYLSVNSLCWAV 369
Cdd:cd17319 243 LRGARRLVIIIGLLLAAVGLLLAYLT----TSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNL 318
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1210186094 370 GYFIGPSLGGWAMDQTSNvISIYWLGLAATTPIAIAILTYL 410
Cdd:cd17319 319 GGFVAPLLIGYLVDATGS-YTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
28-251 |
1.52e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 49.85 E-value: 1.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 28 LLSELGTGFTLFYAPIFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDSpIWGRRKTLLLSAVFSAIGSTVLTATF 107
Cdd:cd17471 6 LLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDR-GGDRKPLILLALLAGALGYLLFAFLR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 108 DF-VTLVIGNIIGGFGAGLYwPATEAVVADLTTPQNRREAYAIT---RLADNLGLGMGIILAGWLVSAGGnFRWLFAIDA 183
Cdd:cd17471 85 NYwVLLLVGVVLLSLGAAAF-PQLFALAREYADRSSGRDATLFNsvlRAAFSLAWVIGPPLAFLLLDVLG-FTGLFLLAA 162
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1210186094 184 TSFVIFFAVIWNAIRETSQLSLGEKKHHLGWSGWRILlqdhILWVYVLVNIMFTTYISQLHSTLPIYL 251
Cdd:cd17471 163 LLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNR----RLLLLFAAFTLLFAANSMYIIAMPLYV 226
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
32-410 |
2.10e-06 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 49.50 E-value: 2.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 32 LGTGFTLFYAPIFFvTKVGLSATSVGIALGTASISGIAGRVCGGLWTDSpiWGRRKTLLLSAVFSAIGSTVLTATFD--F 109
Cdd:cd17335 11 AALGSLLPFLSVYL-KQLGLSPTQIGILIGIRPFVRFLSAPLWGALADR--FGKRKALLLLSLLAAVLFFLSLFFVAqiF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 110 VTLVIGNIIGGFGAGLYWPATEAVVadLTTPQNRREAYAITRLADNLGLGMGIILAGWLV---SAGGNFRWLFAIdatsF 186
Cdd:cd17335 88 WLLLLLVILGAFFSAPVVPLVDSIT--LQYLGEERERYGKQRLWGSIGFGIAALLVGILIdrsSTYKNYTIAFYV----F 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 187 VIFFAVIWNAIRETSQLSLGEKKHHLGWSGWRILLQDHILWVYVLVNIMFTTYISQlHSTLPIYLQRVvvsdGGrlNEGI 266
Cdd:cd17335 162 AVLMLLALLLALKFPFRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLI-YSFLFWHLQDL----GG--SKTL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 267 IAGLFAVHLLMAIVVQLPVAKMLRNLSHPQTLSVSAIIWSGGFAAVWWSgwakSGIWISGIALAIFAIALVSYTPSAAAF 346
Cdd:cd17335 235 IGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFL----ENPWLVLPIELLHGLTFALVWAAAVSY 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1210186094 347 VSEIAPVERR----GIYlsvNSLCWAVGYFIGPSLGGWAMDQTSNVISIYWLGLAATTPIAIAILTYL 410
Cdd:cd17335 311 ASAAAPPGLRataqGLL---QGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
43-394 |
3.16e-06 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 48.90 E-value: 3.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 43 IFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDSpiWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFG 122
Cdd:PRK11646 35 IRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADR--FGAKPMIVTGMLMRAAGFATMAIAHEPWLLWLSCILSGLG 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 123 AGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAggNFRWLFAIDATSFVIffAVIWNAIR---- 198
Cdd:PRK11646 113 GTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQY--DFRLVCATGAVLFVL--AAAFNAWLlpay 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 199 --ETSQLSLGEkkhhlgwsGWRILLQDHILWVYVLVNIMFTTYISQLHSTLPIylqrvvvsdggRLNEgiIAG------- 269
Cdd:PRK11646 189 klSTVRTPVRE--------GMTRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPI-----------MVND--IAGspsavkw 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 270 LFAVHLLMAIVVQLPVAK-MLRNLSHPQTLSVSAIIWSGGFAAVwwsGWAKSGIWISGIaLAIFAIALVSYTPSAAAFVS 348
Cdd:PRK11646 248 MYAIEACLSLTLLYPIARwSEKRFRLEHRLMAGLLIMSLSMFPI---GMVSNLQQLFTL-ICLFYIGSIIAEPARETLSA 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1210186094 349 EIAPVERRGIYLSVNSLCWAVGYFIGPSLGGWAMDqTSNVISIYWL 394
Cdd:PRK11646 324 SLADARARGSYMGFSRLGLALGGAIGYIGGGWLFD-LGKALNQPEL 368
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
4-194 |
3.80e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 48.77 E-value: 3.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 4 QPKSRGGLSIPQFDSQIW-ILAGGRLLSELGTGFtLFYAPIFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDSPI 82
Cdd:cd17475 184 ASTLLRSLKEVLRNRDVWlIAIAGALLVAPQFAL-LTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVF 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 83 WGRRKTLLLSAVFSAIGSTVLTATFDFVT----LVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGL 158
Cdd:cd17475 263 GGRRRPVLVITAAIAAAALLVLSLLSPGTplwlLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGI 342
|
170 180 190
....*....|....*....|....*....|....*.
gi 1210186094 159 GMGIILAGWLVSAGGNFRWLFAIDATSFVIFFAVIW 194
Cdd:cd17475 343 AIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
82-379 |
3.86e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 48.71 E-value: 3.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 82 IWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMG 161
Cdd:cd17321 57 RFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALG 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 162 IILAGWLVSAGGnFRWLFAIdatsFVIFFAVIwnairetsqlslgekkhhlgwsgwrILLQDHILWVYVLVNIMFTTYIS 241
Cdd:cd17321 137 PLLGGLLLELFG-WRWIFLI----NVPIGLVA-------------------------LLLARTFSGAVLAAFLLGAALGG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 242 QLhSTLPIYLQRVvvsdgGRLNEGIIAGLFAVHLLMAIVVQLPVAKMLRNLSHPQTLSVSAIIWSGGFAavWWSGW-AKS 320
Cdd:cd17321 187 LL-FLLPLYLQGV-----LGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLL--LLALLgADS 258
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1210186094 321 GIWISGIALAIFAIALVSYTPSAAAFVSEIAPVERRGIYLSVNSLCWAVGYFIGPSLGG 379
Cdd:cd17321 259 SVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLG 317
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
36-407 |
5.20e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.98 E-value: 5.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 36 FTLFYAPIFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDspIWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIG 115
Cdd:cd17316 18 IGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGD--RIGRKKALILTLLLFGLATLLIGLLPTPILLLVL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 116 NIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGNF---RWLFAIDATSFVIFFav 192
Cdd:cd17316 96 RFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDwgwRILFLIGALPALLAL-- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 193 iwnairetsqlslgekkhhlgwsgwrillqdhILWVYVLVNIMFTTYISQLHSTLPIYLQRVVVSDGGrLNEGIIAGLFA 272
Cdd:cd17316 174 --------------------------------LLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLG-LSPATSSLYLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 273 VHLLMAIVVQLPVAKMLRNLSHPQTLSVSAIIwsGGFAAVWWSGWAKSGIWISGIALAIFAIALVSYTPSAAAFVSEIAP 352
Cdd:cd17316 221 LISLGALVGALIAGLLSDRIGRKKTLVIGLIL--SGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFP 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1210186094 353 VERRGiylSVNSLCWAVGYFIG---PSLGGWAMDQTSNVISIYWLGLAATTPIAIAIL 407
Cdd:cd17316 299 TEVRA---TGVGLSYNLGRLGGggaPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
21-397 |
7.39e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 47.65 E-value: 7.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 21 WILAGGRLLSELGTGFTLFYAPIFFV---TKVGLSATSVGIALGTASISGIAGRVCGGLWTDSpiWGRRKTLLLSAVFSA 97
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIpiiAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDR--FGPRRVMLLGLLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 98 IGSTVLTATFDFVTLVIG-NIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGnFR 176
Cdd:cd17355 80 AGLVLLALATSLWQLYLLwGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFG-WR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 177 WLFAIDATSFVIFFAVIWNAIR----ETSQLSLGEKKHHLGWSGWRILLQDHILWVYVLVNIM--FTTYISQLHstLPIY 250
Cdd:cd17355 159 TALLVLALLALLVLVPVLLLLRrrpaDLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLcgFAVVGLIVH--LVPY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 251 LQrvvvsdGGRLNEGIIAGLFAVHLLMAIVVQLPVAKMLRNLSHPQTLSVSAIIWSGGFAAVWWSGWAKSGIWIsgiALA 330
Cdd:cd17355 237 LA------DRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLL---FAA 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1210186094 331 IFAIALVSYTPSAAAFVSEIAPVERRGIYLSVNSLCWAVGYFIGPSLGGWAMDQTSNVISIYWLGLA 397
Cdd:cd17355 308 LFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVA 374
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
43-194 |
7.43e-06 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 47.61 E-value: 7.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 43 IFFVTKVGLSATSVGIAL---------GTASISGIAGRVCGGL----------WTDspIWGRRKTLLLSAVFSAIGSTVL 103
Cdd:cd17390 1 LYLVGFLDLFGVSMILPLlsthirslgASPTVIGLIGSVYGALqlfssplvgsWSD--VVGRRPVLLICLLLTALGYVLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 104 TATFDFVTLVIGNIIGG-FGAGLywPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGNFRWLFAID 182
Cdd:cd17390 79 GFSTSLALLFLSRIPLGiFKHTQ--SLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLC 156
|
170
....*....|..
gi 1210186094 183 ATSFVIFFAVIW 194
Cdd:cd17390 157 SAIFILNAGLVW 168
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
82-410 |
9.00e-06 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 47.57 E-value: 9.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 82 IWGRRKTLLLSAVFSAIGSTVL-TATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRRE--AYAITRLADNLGL 158
Cdd:cd17346 67 VLGARRTVFIGGILMALGYLLLaLSPFSVSMLYLGLALIIVGNGLFKPNISSLVGKLYDENDPRRdsGFSIFYMGINLGA 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 159 GMGIILAGWLVSAGGnFRWLFAIDATSFVIFFAVIWnaireTSQLSLGEKKHHLgwsgwrillqdhILWVYVLVNIMFTT 238
Cdd:cd17346 147 FLAPLLCGTLGDNYG-YHYGFGLAAVGMLLGLLIFL-----LGRKKLLERKKML------------AIIILFLFAVVFWA 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 239 YISQLHSTLPIYLQRVVvsDGGRLNEGIIAGLFAVHLLMAIVVQLPV--------AKMLRNLSHPQTLSVSAIIWSGGF- 309
Cdd:cd17346 209 IYEQAGTSLALFADENV--DRLLGGFTIPPSWFQSLNPLFIILLAPIlaalwtklGKRGKDPSIPTKFALGLLLLGLSFl 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 310 ----AAVWWSGWAKSGIWISGIALAIFAIALVSYTPSAAAFVSEIAPVERRGIYLSVNSLCWAVGYFIGPSLGG-----W 380
Cdd:cd17346 287 lmvlAASFAGGSGKVSALWLVLSYFLQTLGELCLSPVGLSMITKLAPAKFAGFMMGLWFLASALGNILAGYLAGfyaqpK 366
|
330 340 350
....*....|....*....|....*....|
gi 1210186094 381 AMDQTSNVISIYWLGLAATTpIAIAILTYL 410
Cdd:cd17346 367 DPLASALVYTDYFGLIGVIA-LVAGIILLL 395
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
80-239 |
1.39e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 46.85 E-value: 1.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 80 SPIWGR------RKTLLLSAVFSAIGSTVLTATF-DFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRL 152
Cdd:cd17328 51 SPIFGYlgdrynRKWILAVGILIWSAATLLSSFApNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYF 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 153 ADNLGLGMGIILAGWLVSAGGNFRWLFAIDATSFVIFFAVIWNAIRETSQLSLGEKKHHLG-----WSGWRILLQDhilW 227
Cdd:cd17328 131 AIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKStatsfLADLKALAKN---P 207
|
170
....*....|..
gi 1210186094 228 VYVLVNIMFTTY 239
Cdd:cd17328 208 SFILSTLGFTAV 219
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
50-194 |
1.84e-05 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 46.41 E-value: 1.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 50 GLSATSVGIALGTASISGIAGRVCGGLWTDSpiWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPA 129
Cdd:cd17359 32 NLTPFLEGLVVSSALLGAAIGALFAGRLADR--FGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASAL 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1210186094 130 TEAVVADLTTPQNRREAYAITRLADNLGLGMGIIL---------AGWLVSAGgnFRWLFAIDATSFVIFFAVIW 194
Cdd:cd17359 110 VPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVnylianaggADWLGAEG--WRWMLGLEAIPAILFLLGML 181
|
|
| PRK10054 |
PRK10054 |
efflux MFS transporter YdeE; |
23-421 |
2.02e-05 |
|
efflux MFS transporter YdeE;
Pssm-ID: 182213 Cd Length: 395 Bit Score: 46.27 E-value: 2.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 23 LAGGRLLSELGTGFTLFYAPIFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDSpiWGRRKTLLLSAVFSAIGSTV 102
Cdd:PRK10054 12 LLASSLLLTIGRGATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADK--FDKKRYMLLAITAFASGFIA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 103 LTATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGNFR-WLFAI 181
Cdd:PRK10054 90 IPLVNNVTLVVLFFALINCAYSVFSTVLKAWFADNLSSTSKTKIFSLNYTMLNIGWTVGPPLGTLLVMQSINLPfWLAAI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 182 DAtSFVIFFAVIWnairETSQLSLGEKKHHLGWSGwRILLQDHILWVYVLVNIMFTTYISQLHSTLPIYLqrVVVSDGGr 261
Cdd:PRK10054 170 CS-AFPLVFIQIW----VQRSEKAIATETGSVWSP-SVLLQDKALLWFTCSGFLASFVSGAFASCISQYV--MVVADSD- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 262 LNEGIIAGLFAVHLLMAIVVQLPVAKMLRNLSHPQTLSVSAIIWSGGFAAVWWSGwakSGIWISGIALAIFAIALVSYTP 341
Cdd:PRK10054 241 FAEKVVAVVLPVNAAMVVSLQYSVGRRLNAANIRPLMTAGTLCFVIGLVGFIFSG---NSLLLWGMSAAVFTVGEIIYAP 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 342 SAAAFVSEIAPVERRGIYLSVNSLCWaVGYFIGPSLGGWAMdQTSNVISIYWLGLAAttpIAIAILTYLQRIRNMPIQKP 421
Cdd:PRK10054 318 GEYMLIDHIAPPGMKASYFSAQSLGW-LGAAINPLVSGVIL-TTLPPWSLFVILALA---IVAAWLLMLKGMRARPWGQP 392
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
35-206 |
2.69e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 46.03 E-value: 2.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 35 GFTLFYAPIFfvtKVGLSATSVGIALGTASISGIAGRVCGGLWTDspIWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVI 114
Cdd:cd17315 18 GALLYIAKDL---GFGLSTSLQGLVVSSLLLGAAIGSLFGGPLAD--RFGRRKSLLIAAVLYVIGALLSALAPNVWVLIV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 115 GNIIGGFGAGLYWPATEAVVADlTTPQNRREAYAITRladNLGLGMGIILA-----GWLVSAGGNFRWLFAIdATSFVIF 189
Cdd:cd17315 93 GRFLLGLGVGLASVLVPLYISE-IAPAKIRGALGTLN---QLMITFGILLAyllglALSLSPPGWWRLMFAL-AAVPALL 167
|
170
....*....|....*..
gi 1210186094 190 FAVIWNAIRETSQLSLG 206
Cdd:cd17315 168 QLLLMFFLPESRALLVG 184
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
7-194 |
3.73e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 45.68 E-value: 3.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 7 SRGGLSIPQFDSQIWILAGGRLLSELGTGFTLFYAPIFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWtdSPIWGRR 86
Cdd:cd06173 197 LREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRL--SKRRRRG 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 87 KTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAG 166
Cdd:cd06173 275 RLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAG 354
|
170 180
....*....|....*....|....*...
gi 1210186094 167 WLVSAGGNFRWLFAIDATSFVIFFAVIW 194
Cdd:cd06173 355 LLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
80-193 |
3.91e-05 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 45.73 E-value: 3.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 80 SPIWG-------RRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPATeAVVADLTTPQNRREAYAITRL 152
Cdd:cd17389 81 SPITGaasdvygRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLST-AIVADVTSPKKRSKGMALIGV 159
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1210186094 153 ADNLGLGMGIILAGWLVSAGGNFRWLFAIDATSFVIFFAVI 193
Cdd:cd17389 160 AFSLGFIIGPMIGAYFASFTRSLGEVFFSMPALFALVLALA 200
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
82-379 |
5.16e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 45.29 E-value: 5.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 82 IWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLywPATEAVVADLTTPQNRreAYAITRLADNLGLGM- 160
Cdd:cd17331 61 LFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPSVFMHAM--QAAQMVVTDLTDPGER--AAALGRLGLSYGIGMv 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 161 -GIILAGWLVSAGGNFRWLF---AIDATSFVIFFAVI---WNAIRETSQLSLGEKKHHLGWSGWRILLQDHILWVYVLVN 233
Cdd:cd17331 137 vGSFLGGLLTKKFGEQAAALvaaVGSLLSIVLVILLIpsnTKSKREKEAKESASPPSVFNLKEILRLLRLPGVAFLLLVK 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 234 IMFTTYISQLHSTLPiylqrVVVSDGGRLNEGIIAGLFAVHLLMAIVVQLPVAKMLRNLSHPQTL---SVSAIIWSGGFA 310
Cdd:cd17331 217 LLSGLPIGMFQSMFS-----LVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLlklSVALLAIGYLLL 291
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1210186094 311 AVWWSgwaksgIWISGIALAIFAIALVSYTPSAAAFVSEIAPVERRGIYLSVNSLCWAVGYFIGPSLGG 379
Cdd:cd17331 292 AFVTT------VWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGG 354
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
262-410 |
5.52e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.96 E-value: 5.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 262 LNEGIIAGLFAVHLLMAIVVQLPVAKMLRNLSHPQTLSVSAIIWSGGFAAVWWSgwakSGIWISGIALAIFAIALVSYTP 341
Cdd:COG2814 42 ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA----PSLWLLLAARFLQGLGAGALFP 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1210186094 342 SAAAFVSEIAPVERRGIYLSVNSLCWAVGYFIGPSLGGWAMDQTSnVISIYWLGLAATTPIAIAILTYL 410
Cdd:COG2814 118 AALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWVFLVNAVLALLALLLLLRLL 185
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
54-193 |
6.22e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 45.31 E-value: 6.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 54 TSVGIALGTASISGIAGRVcgglwtdSPIWGRRKTLLLSAVFSAIGSTV-LTATfDFVTLVIGNIIGGFGAGLYWPATeA 132
Cdd:cd06179 37 ISTAWSLAQAVLGPIVGRL-------SDLFGRRWFFIGGNLLGVVGSIVaGTAK-SVNMLIGGQALIGIGAGTQGLGA-A 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1210186094 133 VVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGN-FRWLFAIDATSFVIFFAVI 193
Cdd:cd06179 108 VASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAgWRWIFYINAIFNALALILL 169
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
21-194 |
7.22e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 44.47 E-value: 7.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 21 WILAGGRLLSELGtGFTLFYAPIFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDSPIWGRRKTLLLSAVFSAIGS 100
Cdd:cd17352 186 VLLALGVSFAMLG-FFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 101 TVLTATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGNFRWLFA 180
Cdd:cd17352 265 LAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFY 344
|
170
....*....|....
gi 1210186094 181 IdATSFVIFFAVIW 194
Cdd:cd17352 345 F-CGACLLLSGVLL 357
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
50-181 |
9.73e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 44.11 E-value: 9.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 50 GLSATSVGIALGTASISGIAGRVCGGLWTDSpiWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPA 129
Cdd:cd17365 30 GLSPAQLGPVGSAALFGMAIGALLAGPLADR--FGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPN 107
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1210186094 130 TEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGnFRWLFAI 181
Cdd:cd17365 108 AITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFG-WRSVFLL 158
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
50-407 |
1.08e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 44.09 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 50 GLSATSVGIALGTASISGIAGRVCGGLWTDSpiWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPA 129
Cdd:COG2807 49 GLSATQAGLLTTLPLLAFGLFAPLAPRLARR--FGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 130 TEAVVADLtTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGnFRWLFAIDATSFVIFFAVIWNAIRETSQLSLGEKK 209
Cdd:COG2807 127 LPGLIKRW-FPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALG-WRGALAVWALLALLALLLWLPLLRRRPAAAAAAPA 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 210 HHLGWSGWRILLQDHILWVYVLVNIMFTTYISQlhstLPIYLQrvvvsDGGrLNEGIIAGLFAVHLLMAIVVQLPVAKML 289
Cdd:COG2807 205 AASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAW----LPPILR-----DAG-LSAATAGLLLSLFQLAGIPGSLLVPLLA 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 290 RNLSHPQ-TLSVSAIIWSGGFAAVWWSGWAKSGIWIsgialAIFAIALVSYTPSAAAFVSEIAPveRRGIYLSVNSLCWA 368
Cdd:COG2807 275 DRLGDRRpLLLLLGLLGLAGLLGLLLAPGSLPWLWA-----VLLGLGQGGLFPLALTLIGLRAR--TPAEAAALSGMAQS 347
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1210186094 369 VGY---FIGPSLGGWAMDQTSNVISIYWLGLAATTPIAIAIL 407
Cdd:COG2807 348 VGYllaALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGL 389
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
80-397 |
1.44e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 43.72 E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 80 SPIWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLG 159
Cdd:cd17320 58 SDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 160 MGIILAGWLVSAGGnFRWLFAIDATSFVIFFAVIWNAIRETSQLSLGEKKHHLGWSGWRILLQDHILWVYVLVNIMFTTY 239
Cdd:cd17320 138 LAPLLGGLLLLFFG-WRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAG 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 240 ISQLHSTLPIylqrvVVSDGGRLNEGIIAGLFAVHLLMAIVVQLPVAKMLRNLSHPQTLSVSaiIWSGGFAAVWWSGWAK 319
Cdd:cd17320 217 LFAYLAAAPF-----IYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLG--LLLLLAAALVLLLAAL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 320 SG---IWISGIALAIFAIALVSYTPSAAAFVSEIAPvERRGIYLSVNSLCWAVGYFIGPSLGGWAMDQTSNVISIYWLGL 396
Cdd:cd17320 290 LGglsLWPLVAPLFLIFFGFGLIFPNATSLALEPFP-HVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVL 368
|
.
gi 1210186094 397 A 397
Cdd:cd17320 369 G 369
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
270-386 |
2.01e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.18 E-value: 2.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 270 LFAVHLLMAIVVQLPVAKMLRNLSHPQTLSVSAIIWSGGFAAVWWSgwakSGIWISGIALAIFAIALVSYTPSAAAFVSE 349
Cdd:pfam07690 37 LLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA----SSLWLLLVLRVLQGLGAGALFPAALALIAD 112
|
90 100 110
....*....|....*....|....*....|....*..
gi 1210186094 350 IAPVERRGIYLSVNSLCWAVGYFIGPSLGGWAMDQTS 386
Cdd:pfam07690 113 WFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG 149
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
35-194 |
2.02e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 43.33 E-value: 2.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 35 GFTLFYA-----PIFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDSpiWGRRKTLLLSAVFSAIGSTVLTATFDF 109
Cdd:cd17473 209 AMLLFYVipiqlPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRR--LGKRRLLAIGFALMALGFLLLALASGL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 110 VTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGNFRWLFAIDATSFVIF 189
Cdd:cd17473 287 WVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVL 366
|
....*
gi 1210186094 190 FAVIW 194
Cdd:cd17473 367 AIVLL 371
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
265-421 |
2.48e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.93 E-value: 2.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 265 GIIAGLFAVHLLMAIVVQLPVAKMLRNLSHPQTLSVSAIIWSGGFAAVWWSgwakSGIWISGIALAIFAIALVSYTPSAA 344
Cdd:cd17478 31 AQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFA----PNYWLLLLLVALAGIGSAAFHPEGA 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1210186094 345 AFVSEIAPvERRGIYLSVNSLCWAVGYFIGPSLGGWAMDQTSNVISIYWLGLAAttpIAIAILTYLQRIRNMPIQKP 421
Cdd:cd17478 107 RLASQAAG-GRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPG---LAVALLLLRLRPLKKPEAKK 179
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
230-407 |
2.74e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.97 E-value: 2.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 230 VLVNIMFTTYISQLHSTLPIYLQrvvvSDGGRLNE-GIIAGLFavhLLMAIVVQLPVAKMLRNLSHPQTLSVSAIIWSGG 308
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAH----DLGGSEAVaGLVVGLF---TLAALLARPFAGRLLDRFGRKRLLLIGLLIFALA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 309 FAAVWWSGwaksGIWISGIALAIFAIALVSYTPSAAAFVSEIAPVERRGIYLSVNSLCWAVGYFIGPSLGGWAMDQTsnv 388
Cdd:cd17489 75 TLLYLLAT----SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL--- 147
|
170
....*....|....*....
gi 1210186094 389 iSIYWLGLAATTPIAIAIL 407
Cdd:cd17489 148 -GFAVLFIVAAVLALLALL 165
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
20-194 |
2.94e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.59 E-value: 2.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 20 IWILAGGRLLSELGTGFTLFYAPIFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDspIWGRRKTLLLSAVFSAIG 99
Cdd:cd17316 179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSD--RIGRKKTLVIGLILSGIL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 100 STVLT--ATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGNFRW 177
Cdd:cd17316 257 ALPLFylLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGV 336
|
170
....*....|....*..
gi 1210186094 178 LFAIDATSFVIFFAVIW 194
Cdd:cd17316 337 PALILALLAIVALIVAL 353
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
50-198 |
3.14e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 42.55 E-value: 3.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 50 GLSATSVGIALGTASISGIAGRVCGGLWTDSpIWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGnIIGGFGAGLYWPA 129
Cdd:COG2807 246 GLSAATAGLLLSLFQLAGIPGSLLVPLLADR-LGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWA-VLLGLGQGGLFPL 323
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 130 TEAVVADLT-TPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGNFRWLFAIDATSFVIFFAVIWNAIR 198
Cdd:COG2807 324 ALTLIGLRArTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGR 393
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
9-172 |
3.27e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 42.55 E-value: 3.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 9 GGLSIPqFDSQIWILAGGRLLSELGTGFTLFYAPIFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTdsPIWGR-RK 87
Cdd:cd17502 159 GGLALA-LLRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALI--SKTGRyKP 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 88 TLLLSAVFSAIGS---TVLTATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGI-I 163
Cdd:cd17502 236 LIVIGTILMSVGAgllTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVaI 315
|
....*....
gi 1210186094 164 LAGWLVSAG 172
Cdd:cd17502 316 TDVFLVALA 324
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
17-194 |
3.30e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 42.64 E-value: 3.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 17 DSQIWILAGGRLLSELGTGFTLFYAPIFFVTKvGLSATSVGIALGTASISGIAGRVCGGLWTDSpiWGRRKTLLLSAVFS 96
Cdd:cd17355 209 SASFWLLALAFFLCGFAVVGLIVHLVPYLADR-GISPAAAAVALALIGLFNIVGRLLSGWLGDR--YSPRRLLAASYALR 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 97 AIGSTVLTA-TFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGNF 175
Cdd:cd17355 286 ALGLALLLLlPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSY 365
|
170
....*....|....*....
gi 1210186094 176 RWLFAIDATSFVIFFAVIW 194
Cdd:cd17355 366 TAAWALAVALGLIAALLVL 384
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
82-379 |
4.01e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 42.18 E-value: 4.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 82 IWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYwPATEAVVADLTTPQNRREAYAItrLADNLGLGMG 161
Cdd:cd17504 57 LYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPERVPVAQGI--LSATFGIGAG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 162 I--ILAGWLVSAGGnFRWLFAIDATSFVIFFAVIwnairetSQLSLGekkhhlgwsgwriLLQDHILWVYVLVNIMFTTY 239
Cdd:cd17504 134 IglPLGGWIVQHLG-WRWIFWTAAPVAVLLAALV-------PLIDLR-------------LLRRRNVLLANITALLAGFG 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 240 ISQLHSTLPIYLQRVVVSDGGRLNEGIIAGLFAVHLLMAIVVQLpVAKMLRNLSHPQTLSVSAIIWSGGFAAVWWSGwak 319
Cdd:cd17504 193 MFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPL-AGRLIARVGPRRVLLIGLVISAVGLLLLALLH--- 268
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 320 SGIWISGIALAIFAIALVSYTPSAAAFVSEIAPVERRGIYLSVNSLCWAVGYFIGPSLGG 379
Cdd:cd17504 269 SSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAG 328
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
84-181 |
4.53e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.18 E-value: 4.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 84 GRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGII 163
Cdd:cd17503 59 GTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPT 138
|
90
....*....|....*...
gi 1210186094 164 LAGWLVSAgGNFRWLFAI 181
Cdd:cd17503 139 LGGWLTDN-LSWRWIFYI 155
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
80-379 |
5.27e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 41.87 E-value: 5.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 80 SPIWGR------RKTLLLSAvfsAIGSTVLTATFDFVT----LVIGNIIGGFGAGlYWPATEAVVADlTTPQNRrEAYAI 149
Cdd:cd17391 53 SPIWGRladrygRKPMLLRA---SLGMAIVIGLMAFVTnvwqLLILRLLQGVFSG-YVPNATALIAS-QTPKEK-SGWAL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 150 TRLADNLGLG--MGIILAGWLVSAGGnFRWLFAIdaTSFVIFFAVIWNA--IRETSQlSLGEKKHHLGWSGWRILLQDHI 225
Cdd:cd17391 127 GTLSTGVVAGtlIGPLLGGFLADLFG-IRNVFFI--TGGLLFLAFLLTLffVKEDFK-PVEKKKMVSTKEVWNSVPNPSL 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 226 LWVyvlvnIMFTTYISQL--HSTLPIYLQRVVVSDGGRLNEGIIAGL-FAVHLLMAIVVQLPVAKMLRNLSHPQTLSVSA 302
Cdd:cd17391 203 LIS-----LFVTTFIIQLanQSIEPILTLYIRQLMGDASNLAFISGLvFSATGVSSLLSAPRLGKLGDRIGHHRILLGAL 277
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1210186094 303 IIwsggFAAVWWSGWAKSGIWISGIALAIFAIALVSYTPSAAAFVSEIAPVERRGIYLSVNSLCWAVGYFIGPSLGG 379
Cdd:cd17391 278 LA----SALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGS 350
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
28-172 |
6.35e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.77 E-value: 6.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 28 LLSELGTGFTLFYAPIFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDSpiWGRRKTLLLSAVFSAIGS---TVLT 104
Cdd:cd17321 178 FLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADR--FGPRLVLVAGLLLTAVGLlllALLG 255
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1210186094 105 ATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAG 172
Cdd:cd17321 256 ADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAG 323
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
60-181 |
8.20e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 41.40 E-value: 8.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 60 LGTASISGIAGRVcgglwtdSPIWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTT 139
Cdd:cd17502 41 LTSTAFQPIYGKL-------SDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVP 113
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1210186094 140 PQNRREAYAITRLADNLGLGMGIILAGWLVSAGGnFRWLFAI 181
Cdd:cd17502 114 PRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLS-WRWCFYI 154
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
34-194 |
8.34e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 41.49 E-value: 8.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 34 TGFTLFYAPIFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDspIWGRRKTLLLSAVFSAIGSTVLTATFDFVT-- 111
Cdd:pfam00083 26 IDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGD--RFGRKKSLLIANVLFVIGAVLQGAAKGKWSvy 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 112 -LVIGNIIGGFGAGLYWPATEAVVADLTTPQNRreaYAITRLaDNLGLGMGIILAGWLV------SAGGNFRWLFAIDAT 184
Cdd:pfam00083 104 qLIVGRVLVGIGVGGASVLAPMYISEIAPKKLR---GALGSL-YQLAITFGILLAYIFGlglnktSNSDGWRIPLGLQLV 179
|
170
....*....|
gi 1210186094 185 SFVIFFAVIW 194
Cdd:pfam00083 180 PALLLIIGLL 189
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
20-187 |
1.17e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 41.07 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 20 IWILAGGRLLSELGTGFTLFyAPIFFVT---KVGLSATSVGIALGTAS-ISGIAGRVCGGLWTDSPIWGRRKTLLLSAVF 95
Cdd:cd17328 210 ILSTLGFTAVSFVTGALAFW-APTFFLRafgVGDLSSADVGLIFGAITcIAGVLGVLLGGILADRLRRKTPRADPLVCAV 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 96 SAIGST------VLTATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADN-LGLGMGIILAGWL 168
Cdd:cd17328 289 GLLAAApflflaLVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHlLGDAGSPYLIGLI 368
|
170
....*....|....*....
gi 1210186094 169 VSAGGNFRWLFAIDATSFV 187
Cdd:cd17328 369 SDLLRQNKDSPLAEAASLQ 387
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
20-232 |
1.94e-03 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 40.06 E-value: 1.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 20 IWILAGGRLLSELGTGFTLFYAPiFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDSpiWGRRKTLLLSAVFSAIG 99
Cdd:TIGR00710 7 ALLLGCLSILGPLGIDMYLPAFP-EIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDR--YGRRPVLLLGLFIFALS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 100 STVLTATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGnFRWLF 179
Cdd:TIGR00710 84 SLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLS-WHAIF 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1210186094 180 AIDATSFVIFFAVIWNAIRETSQLslgEKKHHLG--WSGWRILLQDHILWVYVLV 232
Cdd:TIGR00710 163 AFLSLAGILLSALIFFILPETLPY---EARIQIStyFETFLLLLKSKMFWGYALI 214
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
40-130 |
2.45e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.84 E-value: 2.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 40 YAPIFFVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDspIWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIG 119
Cdd:COG0738 232 WLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLK--RFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALV 309
|
90
....*....|.
gi 1210186094 120 GFGAGLYWPAT 130
Cdd:COG0738 310 GLGLSLMFPTI 320
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
52-190 |
2.98e-03 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 39.56 E-value: 2.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 52 SATSVGIALGTASISGIAGRvcgglwtdspiWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPATE 131
Cdd:cd17360 42 SSTVAGAAVGAAIGGWLNDR-----------FGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVP 110
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1210186094 132 AVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGNFRWLFAIDATSFVIFF 190
Cdd:cd17360 111 LYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPGGWRWMLGLAAVPAVLQF 169
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
39-173 |
3.57e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.13 E-value: 3.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 39 FYAPIF--FVTKVGLSATSVGIALGTASISGIAGRVCGGLWTDSpIWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGN 116
Cdd:cd17490 14 VYVPFLspYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDR-IGKRKLFIIIGLLFTVLASLIMILFPSPWGLLIAR 92
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1210186094 117 IIGGFGAGlYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGG 173
Cdd:cd17490 93 FLSGIAAA-TWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFG 148
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
50-181 |
5.19e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.82 E-value: 5.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 50 GLSATSVGIALGTASISGIAGRVCGGLWTDSpiWGRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPA 129
Cdd:cd17371 30 GLDEAEAGLLGTVTLAGGAIGGILGGILADR--FGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAA 107
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1210186094 130 TEAVVADLTTPQNRREAYAITRLADNLGLGMGIILAGWLVSAGGN---FRWLFAI 181
Cdd:cd17371 108 GAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPeiaWRVLFLL 162
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
84-197 |
5.40e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.78 E-value: 5.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210186094 84 GRRKTLLLSAVFSAIGSTVLTATFDFVTLVIGNIIGGFGAGLYWPATEAVVADLTTPQNRREAYAITRLADNLGLGMGII 163
Cdd:cd17391 268 GHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPL 347
|
90 100 110
....*....|....*....|....*....|....
gi 1210186094 164 LAGwLVSAGGNFRWLFAIdaTSFVIFFAVIWNAI 197
Cdd:cd17391 348 LGS-AIAAHFGYRAVFVV--TALLVLLNAIWSFI 378
|
|
| |
