|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
5-403 |
1.29e-41 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 153.08 E-value: 1.29e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 5 ISKNLAYNMGYQLIGIAAPLITSPYLSRILGAENLGIHSFTMSVALYFMMFMLLGIANYGNRTIAtvkREGKDILSKTFW 84
Cdd:cd13128 1 LAKNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIA---RYRKEKIREIIS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 85 SIYSIQLIMSILVTIAYLAYLYLGAVH-------YKVIAILQLFLLLSNAvdITWFFYGLENFKQIVFRNTLVKLLGLFL 157
Cdd:cd13128 78 TSLVLKLILGILALLLLFLFAFLIAFYdpelvllLYILALSLPFSALNSL--FRGIFQGFEKMKYIVIARIIESVLSLIL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 158 IFLCVRQGTDLWKYTFIN---GSVTLVGQLLLWGQLKGILTWKKIQLKELLPHIKPILILFIPVLAISIFTNMDKYMLGL 234
Cdd:cd13128 156 ALILVLLGGGLIGFALAYliaSVLSAILLLYIYRKKILLPKFFSFDLKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGY 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 235 MVDVKQVGFYDNAGRIIEIPKALIAALGAVMLPRTSYLLAEGqKEKSKYYIEVTILYVMIISSVLMFGLISVSDIFSIIF 314
Cdd:cd13128 236 FLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELYKND-KDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 315 WGEEFLESGRLISAMSPAFVFSVLGNIIrTQYLIPRAKDKDYVVSLIAGAVVNLVLNYFFIKPFGAMGATVSTVLAEFVL 394
Cdd:cd13128 315 FGEEYLPAALVLQILAWGFLFIFLNGIF-GSILQAIGKQKLTLKILLIGALLNVILNLLLIPKYGIIGAAIATLISEFII 393
|
....*....
gi 1209454071 395 SGMQFWSVR 403
Cdd:cd13128 394 FILLLYLLK 402
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
3-399 |
1.57e-36 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 138.54 E-value: 1.57e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 3 NKISKNLAYNMGYQLIGIAAPLITSPYLSRILGAENLGIHSFTMSVALYFMMFMLLGIANYGNRTIAtvkREGKDILSKT 82
Cdd:COG2244 2 KKLLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIVALLSVLADLGLSTALVRFIA---EYREEELRRL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 83 FWSIYSIQLIMSILVTIAYLAYLYLGAVHYK------VIAILQLFLLLSNAVDI-TWFFYGLENFKQIVFRNTLVKLLGL 155
Cdd:COG2244 79 LSTALLLRLLLSLLLALLLLLLAPFIAALLGepelalLLLLLALALLLSALSAVlLALLRGLERFKLLALINILSSLLSL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 156 FLIFLCVRQGTDLWKYTFINGsvtlvgqlllwgqlkgiltwkkiqlkellphikpiLILFIPVLAISIFTNMDKYMLGLM 235
Cdd:COG2244 159 LLALLLALLGLGLWGLVLKYS-----------------------------------LPLLLSGLLGLLLTNLDRLLLGAL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 236 VDVKQVGFYDNAGRIIEIPKALIAALGAVMLPRTSYLLAEGQKEKSKYYIEVTILYVMIISSVLMFGLISVSDIFSIIFW 315
Cdd:COG2244 204 LGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLSLLF 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 316 GEEFLESGRLISAMSPAFVFSVLGNIIrTQYLIPRAKDKDYVVSLIAGAVVNLVLNYFFIKPFGAMGATVSTVLAEFVLS 395
Cdd:COG2244 284 GPEYAEAAPVLPILALGALFLALSGVL-SNLLLALGRTRLLLIISLIGAVLNLVLNLLLIPRYGLVGAAIATLLSYLVLL 362
|
....
gi 1209454071 396 GMQF 399
Cdd:COG2244 363 LLLL 366
|
|
| Polysacc_synt |
pfam01943 |
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ... |
7-270 |
4.11e-16 |
|
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.
Pssm-ID: 426523 [Multi-domain] Cd Length: 274 Bit Score: 78.50 E-value: 4.11e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 7 KNLAYNMGYQLIGIAAPLITSPYLSRILGAENLGIHSFTMSVALYFMMFMLLGIANYGNRTIAtVKREGKDILSKTFWSI 86
Cdd:pfam01943 3 KNVIVLLLSQLITYLLAFVTLPYLARILGPEGFGLYAFALAFVGLLTIFTDFGFNAALVREIA-KYREKYELVSLYWLNA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 87 YSIQLIMSILVTIAYLAYLYLGAVHYKV---IAILQLFLLLSNAVDITWFFYGLENFKQIVFRNTLVKLLGLFLIFLCVR 163
Cdd:pfam01943 82 LLVKLVLVLLFLLLPLIAAFLGLPELAVlyrILALMFLLLPGVVQFRRGLFQGLERMKYALISQIVESLSRVILVFIAVF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 164 QGTDLWKYTFINGSVTLVGQLLLWGQLKGILT--WKKIQLKELLPHIKPILILFIPVLAISIFTNMDKYMLGLMVDVKQV 241
Cdd:pfam01943 162 LPGDIVAALLYQVLAALVGGIIALAVLRKIFRprFVFPSLKLVRKLLSFGAPLFISSLAISLYTYIDSILLGLLLGAGAV 241
|
250 260 270
....*....|....*....|....*....|
gi 1209454071 242 GFYDNAGRIIEIPKALIA-ALGAVMLPRTS 270
Cdd:pfam01943 242 GIYNAAYQLLVAIQGLLNpIVTAVLFPVFS 271
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
325-458 |
3.68e-13 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 66.44 E-value: 3.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 325 LISAMSPAFVFSVLgNIIRTQYLIPRAKDKDYVVSLIAGAVVNLVLNYFFIKPFGAMGATVSTVLAEFVLSGMQFWSVRR 404
Cdd:pfam14667 1 VLQILALSIIFLSL-STVLTSILQGLGRTKLALIALLIGALVKLILNLLLIPLFGIVGAAIATVISLLVVALLNLYYLRR 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1209454071 405 DLDLKRYLKNGLIFYLFGLIM---HLIIIALKTQLPYNIMSLILLIVLGGIVYVIFC 458
Cdd:pfam14667 80 YLGLRLLLRRLLKPLLAALVMgivVYLLLLLLGLLLGLALALLLAVLVGALVYLLLL 136
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
206-458 |
6.79e-13 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 70.56 E-value: 6.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 206 PHIKPILILFIPVLA------ISIFTNMdkyMLGLMVDVKQVGFYDNAGRIIEIPKALIA-ALGAVMLPRTSYLLAEGQK 278
Cdd:COG0728 219 PGVRRVLKLMLPALLgvsvsqINLLVDT---ILASFLPEGSVSALYYADRLYQLPLGLFGvAIGTALLPRLSRAAAAGDL 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 279 EKSKYYIEVTILYVMIISSVLMFGLISVSD-IFSIIFWGEEF-----LESGRLISAMSPAFVFSVLGNIIrTQYLIPRAK 352
Cdd:COG0728 296 EEFRRTLSRGLRLVLLLTLPAAVGLIVLAEpIVRLLFERGAFtaedtALTALALAAYALGLPAFALVKVL-ARAFYARQD 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 353 DKDYVVSLIAGAVVNLVLNYFFIKPFGAMGATVSTVLAEFVLSGMQFWSVRRDL---DLKRYLKNGLIFYLFGLIMHLII 429
Cdd:COG0728 375 TRTPVRIAVIAVVVNIVLNLLLVPPLGHAGLALATSLSALVNALLLLVLLRRRLgglPLRGILRTLLKLLLASLVMGAVL 454
|
250 260 270
....*....|....*....|....*....|....*..
gi 1209454071 430 IALKTQLP--------YNIMSLILLIVLGGIVYVIFC 458
Cdd:COG0728 455 WLLLRLLGdwlgggllGRLLALALLILVGAAVYFALL 491
|
|
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
246-457 |
1.11e-12 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 70.19 E-value: 1.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 246 NAGRIIEIPKALIAALGAVMLPRTSYLLAEGQKEKSKYYIEVTILYVMIISSVLMFGLISVSDIFSIIFWGEEflESGRL 325
Cdd:COG5841 284 MAQPLVNLPTVLATALATSLVPAISEAFAKKDRKLVRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGNP--EGGGI 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 326 ISAMSPAFVFSVLGNIIRT------QYLIPrakdkdyVVSLIAGAVVNLVLNYFFIKPFGAMGATVSTVLAEFVLSGMQF 399
Cdd:COG5841 362 LAILAPSAIFLSLQQVTTGilqglgKQKIP-------VINLLIGLLVKIILNYLLVPLFGIYGAALATVIGYLVAAILNL 434
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1209454071 400 WSVRRDLDLKRYLKNGLIFYLFG---------LIMHLIIIALKTQLPYNIMSLILLIVLGGIVYVIF 457
Cdd:COG5841 435 AALKKYTGFKLDLRRRLLKPLLAslimgivvlLLYRLLSLFLPESRLGALLATLIAVLVGAIVYLLL 501
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
5-408 |
1.17e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 69.44 E-value: 1.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 5 ISKNLAYNMGYQLIGIAAPLITSPYLSRILGAENLGIHSFTMSVALYFMMFMLLGIANygnrtiATVKRegKDILSKTFW 84
Cdd:cd13127 1 AVSGAFWSAISQVVVQLLQFVVTIILARLLTPEDFGLVAMATVFIAFAQLFSDLGLSS------ALIQR--KDLTEEDLS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 85 SIYSIQLIMSILVTIAYLAYLYLGAVHYKVIAILQLFLLLSnavdITWFFYGLE-----------NFKQIVFRNTLVKLL 153
Cdd:cd13127 73 TVFWLNLLLGLLLYLLLFLLAPLIAAFYNEPELIPLLRVLS----LSFLLSGLGsvprallqrelRFKKLAIIELISTLV 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 154 GLFLIFLCVRQGTDLWKYTFINGSVTLVGQLLLWgqlkgILTWKKIQLKELLPHIKPILILFIPVLAISIF----TNMDK 229
Cdd:cd13127 149 SGVVAIVLALLGFGVWALVAQQLVGALVSTVLLW-----ILSRWRPRLSFSLASLKELLSFGSKLLGSNLLnyfsRNLDN 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 230 YMLGLMVDVKQVGFYDNAGRIIEIP-KALIAALGAVMLPrtsyLLAE--GQKEKSKYYIEVTILYVMIISSVLMFGLISV 306
Cdd:cd13127 224 LIIGKFLGAAALGYYSRAYRLALLPvQNITGPITRVLFP----ALSRlqDDPERLRRAYLKALRLLALITFPLMVGLALL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 307 SDIFSIIFWGEEFLESGRLISAMSPAFVFSVLGNIIRTQYLIPRAKDKDYVVSLIaGAVVNLVLNYFFIkPFGAMGATVS 386
Cdd:cd13127 300 AEPLVLLLLGEKWLPAVPILQILALAGLFQPLSSLNGSLLLALGRTDLLLKLGLI-KAVLTVLALLIGI-PYGIIGVAIA 377
|
410 420
....*....|....*....|..
gi 1209454071 387 TVLAEFVLSGMQFWSVRRDLDL 408
Cdd:cd13127 378 YVIASLLSFPLNLYLAGRLIGI 399
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
206-404 |
7.41e-11 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 64.01 E-value: 7.41e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 206 PHIKPILILFIPVLA------ISIFTNMdkyMLGLMVDVKQVGFYDNAGRIIEIPKALIA-ALGAVMLPRTSYLLAEGQK 278
Cdd:cd13123 212 PGVRRVLKLMLPALLgvsvsqINLLVDT---ILASFLPEGSISALYYADRLYQLPLGIFGvAIATALLPRLSRLAAAGDL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 279 EKSKYYIEVTILYVMIISSVLMFGLISVSD-IFSIIFWGEEF-----LESGRLISAMSPAFVFSVLGNII-RTQYLIpra 351
Cdd:cd13123 289 DEFRRTLSRGLRLVLFLLLPAAVGLIVLAEpIVRLLFERGAFtaedtLMTASALAAYALGLPAFALVKLLsRAFYAL--- 365
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1209454071 352 kdKDYVVSLIAGAV---VNLVLNYFFIKPFGAMGATVSTVLAEFVLSGMQFWSVRR 404
Cdd:cd13123 366 --KDTKTPVKIAVIavaVNILLNLLLIKPLGHVGLALATSLSAWVNALLLLVLLRR 419
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
243-408 |
5.32e-09 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 58.25 E-value: 5.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 243 FYDNAGRIIEIPKALIAALGAVMLPRTSYLLAEGQKEKSKYYIEVTILYVMIISSVLMFGLISVSDIFSIIFWGEEflES 322
Cdd:cd13124 272 LTGRAQPLVQLPTVIATALSTSLVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDS--EG 349
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 323 GRLISAMSPAFVFSVLGNIIrTQYLIPRAKDKDYVVSLIAGAVVNLVLNYFFIKPFGAMGATVSTVLAEFVLSGMQFWSV 402
Cdd:cd13124 350 GLILQILAPSILFLSLQQVT-AAILQGLGKVKIPVINLLIGLLVKIVLNYVLIPIFGIYGAAIATVIGFLVAALLNLRAL 428
|
....*.
gi 1209454071 403 RRDLDL 408
Cdd:cd13124 429 KKLLGF 434
|
|
| MATE_like_10 |
cd13125 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
7-404 |
1.11e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240530 [Multi-domain] Cd Length: 409 Bit Score: 50.62 E-value: 1.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 7 KNLAYNMGYQLIGIAAPLITSPYLSRILGAENLGIHSFTMSVALYFMMFMLLGIANYGNRTIATVKR---EGKDILSKTF 83
Cdd:cd13125 1 KVSSLSGISTLIKILAGLIINKVVAVYLGPSGVALLGQLQNFVTILQTIAGGGINNGVVKYTAEYKDdeeKLARVWSTAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 84 WSIYSIQLIMSILVTIA--YLAYLYLGAVHY----KVIAILQLFLLLSNAvdITWFFYGLENFKQIVFRNTLVKLLGLFL 157
Cdd:cd13125 81 RITLILSILGGLLLLLFskPLSSLLFGDIDYswvfILLGLALPLFALNNL--LLAILNGLKEIKRYALINIISSLIGLLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 158 IFLCVrqgtdlWKYTFINGSVTLVGQLLLWG-------QLKGILTWKKIQLKELLPHIKPILILFIPVLAISIFTNMDKY 230
Cdd:cd13125 159 SVLLV------YFYGLKGALLALVLNQSLIFlvtliysRKQPWFKLKYLWGRLDKDIIKKLLKFSLMALVSALSLPLSQI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 231 ----MLGLMVDVKQVGFYDNAGRIIEIPKALI-AALGAVMLPRTSyllaeGQKEKSKYYIEV-----TILYVMIISSVLM 300
Cdd:cd13125 233 ivrnILIRQLGWEAAGYWQAVWKISDVYLGFItTALSTYYLPRLS-----AIKDNKELKREVnkqlkVILPLVAIGALLI 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 301 FGLISVsdIFSIIFwGEEFLEsgrlisaMSPAFVFSVLGNIIRTQ------YLIPRAKDKDYVVSLIAGAVVNLVLNYFF 374
Cdd:cd13125 308 YLLRDL--IIQILF-SEEFLP-------ARELFLWQLIGDFFKIAswllgyILLAKGMTKLFIITEILFALLFVLLSLLF 377
|
410 420 430
....*....|....*....|....*....|
gi 1209454071 375 IKPFGAMGATVSTVLAEFVLSGMQFWSVRR 404
Cdd:cd13125 378 IPLFGLEGAGIAYAINYILYLILMYFIFRK 407
|
|
| Polysacc_synt_3 |
pfam13440 |
Polysaccharide biosynthesis protein; |
30-322 |
2.82e-06 |
|
Polysaccharide biosynthesis protein;
Pssm-ID: 404342 [Multi-domain] Cd Length: 293 Bit Score: 49.13 E-value: 2.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 30 LSRILGAENLGIHSFTMSVALYFMMFMLLGIANygnrtiATVKRegKDILSKTFWSIYSIQLIMSILVTIA------YLA 103
Cdd:pfam13440 2 LARLLSPEDFGVVAIATVVISFANIFVDMGFSS------ALIQK--KDITETDYSTVFTFNLIFGALIYLIlfalapLIA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 104 YLYLGAVHYKVIAILQLFLLLSNAVDI-TWFFYGLENFKQIVFRNTLVKLLGLFLIFLCVRQGTDLWkytfingsvTLVG 182
Cdd:pfam13440 74 SFYNQPELVPVLRVLALVLILNGLSSVqTALLRRDLRFKKLFKITLTSSVIGGIVGIVLAYLGFGVW---------ALVI 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 183 QLLLWGQLKGILTW----KKIQLKELLPHIKPILILFIPVLAISI----FTNMDKYMLGLMVDVKQVGFYDNAGRIIEIP 254
Cdd:pfam13440 145 GTLAQQLLSLVLLWlasdWRPRLTFSLKVIKELFSFGSWLLLSNLlnylARNLDNLIIGKVLGTAALGLYSVAYRLALLP 224
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1209454071 255 KALI-AALGAVMLPRTSYLLAEGQKEKSKYYieVTILYVMIISSVLMFGLISVSDIFSIIFWGEEFLES 322
Cdd:pfam13440 225 TANItSVITKVLFPALSRIQDDKAKLRELYL--RVLRLIAFIVFPIMAGLAVVAEPLVLVLLGSQWLES 291
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
209-418 |
1.06e-04 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 44.36 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 209 KPILILFIPVLAISIFTNM----DKYMLGLM--VDVKQVGFydnAGRIIEIPKALIAALGAVMLPRTSYLLAEGQKEKSK 282
Cdd:COG0534 8 KLLLRLALPIILGNLLQSLyglvDTIFVGRLgtAALAAVGL---AFPIFFLLIALGIGLGVGGTALVAQALGAGDREEAR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 283 YYIEVTILYVMIISSVLM-FGLISVSDIFSIIFWGEEFLESGRL-ISAMSPAFVFSVLGNIIRtQYLIPRAKDKDYVVSL 360
Cdd:COG0534 85 RVLGQALLLALLLGLLLTlLGLLFAPPLLRLLGADPEVLALARDyLRIILLGLPFLLLFNVLN-GILRGLGDTKTPMIIM 163
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 361 IAGAVVNLVLNYFFIKPF--GAMGATVSTVLAEFVLSGMQFWSVRRDLDLKRYLKNGLIF 418
Cdd:COG0534 164 LIGNVLNIVLDPLLIFGGglGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRP 223
|
|
| MATE_epsE_like |
cd13129 |
Multidrug and toxic compound extrusion family and similar proteins; This model represents a ... |
7-394 |
1.73e-04 |
|
Multidrug and toxic compound extrusion family and similar proteins; This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins, including Ralstonia solanaceraum GMI1000 epsE, which may be involved in exporting exopolysaccharide EPS I, a virulence factor. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240534 [Multi-domain] Cd Length: 411 Bit Score: 44.02 E-value: 1.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 7 KNLAYNMGYQLIGIAAPLITSPYLSRILGAENLGIHSFTMSVALYFMMFMLLGIANYGNRTIATVKREGKDILSKTFWSI 86
Cdd:cd13129 4 SGSFWSLGGLVASRGAVFLTNIMVARSLGKHVFGEFGVIQVTIGLLGTFAGFGLGLAATKVIAETKDVDPERAGRIIGLS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 87 YSIQLIMSILVTIA------YLAYLYLGAVHYKVIAILQLFLLLSNAVD--ITWFFYGLENFKQIVFRNTLVKLLG--LF 156
Cdd:cd13129 84 ILLAVVTGALAATVlflsatWIAIATLNAPHLAELLRIAAIILILTAFTgaQTGFLSGFEAFRAIARVNIWAGLLLlpLM 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 157 LIFLCVRQGTD-LWKYTFINGSVTLVGQLLLWGQLKGI-LTWKKIQLKELLphiKPILILFIP-VLAISIFTNMDKYMLG 233
Cdd:cd13129 164 WIGVYIRGLVGaVVILLASAAGNVASNSLILRRECQNQrGPVRTGLTWQEL---RVLFKFSLPsVLSGSMGSPVHWIALA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 234 LMVD----VKQVGFYDNAGRIIEIPKALIAALGAVMLPrtsyLLAE--GQKEKS-KYYIEVTILYVMIISSVLMFGLISV 306
Cdd:cd13129 241 ILVNqpngYAELGLFNAANQWRQFITFLPATLGNVALP----FLAEnfGNNEGMfRQTFRSALLFGLGLSLPLGCVFILA 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 307 SDIFsIIFWGEEFLESGRLISAMSPAFVFSVLGNIIRTQYLIPRAKDKDYVVSlIAGAVVNLVLNYFFIKPFGAMGATVS 386
Cdd:cd13129 317 SQIF-AWLYGKEYGSAAASMRSLAVAAILVGLSVLLGQIIASSGKIWRGFALN-MVWSVIYVAAAYLLLRLYGAPGLALA 394
|
....*...
gi 1209454071 387 TVLAEFVL 394
Cdd:cd13129 395 MSAAYCVL 402
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
10-399 |
1.95e-04 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 43.85 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 10 AYNMGYQLIGIAAPLITSPYLSRILGAENLGIHSFTMSVALYFMMFMLLGIAnyGNRTIATVKREGK-DILSKTFWSIYS 88
Cdd:cd12082 2 APLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVG--TSALISQAIGAGDeEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 89 IQLIMSILVTIAYL--------------AYLYLGAVHYKVIAILQLFLLLSNAvdITWFFYGLENFKQIVFRNTLVKLLG 154
Cdd:cd12082 80 LAILLGLLLAALLLffsplilsllgaeeEVIELAATYLTILILGLPITFLGAV--LSGILQGEGDTRTAMIISVLSNLLN 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 155 LFLIFLCVRQGTDLWKYTFINGSVTLVGQLLLWGQLKGILTWKKIQLKELLPHIKPILILFIPVLAISI----------- 223
Cdd:cd12082 158 ILLDPLLIFGLGPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLpsaiqnsllsl 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 224 -FTNMDKYMLGLMVDVKQVGfYDNAGRIIEIPKALIAALGAVMLPRTSYLLAEGQKEKSKYYIEVTILYVMIISSVLMFG 302
Cdd:cd12082 238 gLLIIVAIVAAFGGAAALAA-YTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 303 LISVSD-IFSIIFWGEEFLESGRLISAMSPAFVFSVLGNIIRTQYLIPRAK-DKDYVVSLIAGAVVNLVLNYFFIK-PFG 379
Cdd:cd12082 317 ILLFPEpILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRtLKSLIVSLLSYWVVRLPLAYVLAYlGLG 396
|
410 420
....*....|....*....|
gi 1209454071 380 AMGATVSTVLAEFVLSGMQF 399
Cdd:cd12082 397 LYGIWLALVISLILAALVLL 416
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
197-449 |
2.52e-04 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 43.43 E-value: 2.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 197 KKIQLKELLPHIKPILILFIPVL---AISIFTNMDKYMLGLMVDVKQVGFYDNAGRIIEIPKALIA-ALGAVMLPRTSYL 272
Cdd:pfam03023 185 LKPRFGFRDKGLKRFLKLMLPTLlgvSVSQLNLLIDTFLASFLAPGSVSYLYYADRIYQLPLGIFGvSISTVLLPRLSRH 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 273 LAEGQKEKSKYYIEVTILYVMIISSVLMFGLISVSD-IFSIIFWG-----EEFLESGRLISAMSPAFVFSVLGNIIRTQY 346
Cdd:pfam03023 265 AADGDWDEFRDLLDQAIRLTLLLMIPVSFGLLVLSIpIVSLLFERgnfspEDVTATAEVLAAYALGLIPYALVKLLSRVF 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 347 LIPRAKDKDYVVSLIAgAVVNLVLNYFFIKPFGAMGATVSTVLAEFVLSGMQFWSVRRDLDLkrYLKNGLIFYLFGLIMH 426
Cdd:pfam03023 345 YAREDTKTPFKISLIS-AVLNILLSLLLLPPLGVAGLALATSLSSLIGLVFLYYILRKRLGG--FDLRGIKTFLASLVVP 421
|
250 260 270
....*....|....*....|....*....|
gi 1209454071 427 LIIIAL-------KTQLPYNIMSLILLIVL 449
Cdd:pfam03023 422 TALMAGvilllssLTQGPWVVGSLLLILVG 451
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
290-432 |
3.24e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 42.90 E-value: 3.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 290 LYVMIISSVLMFGLISV--SDIFSIIFWGEEFLESGRL-ISAMSPAFVFSVLGNIIRTqYLIPRAKDKDYVVSLIAGAVV 366
Cdd:cd13133 88 LYFSLLLAPLLALLSALaaPLLFLLLGHSPEVQALEVEyFRIRILGAPFSLLGAALRA-FFSGIGRTRVVMVANLVMVVV 166
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1209454071 367 NLVLNYFFI---KPFGAM---GATVSTVLAEFVLSGMQFWSVRRDLDLKRYLKNGLIFYLFGLIMHLIIIAL 432
Cdd:cd13133 167 NIVLDYALIfgkLGFPAMgiaGAAIATVIAEAVSLLFFLLLLFRRKNRRRFGLRRAWRFDRELLRRILRLGL 238
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
209-457 |
5.21e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 42.50 E-value: 5.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 209 KPILILFIPVLAISIFtnmdkYMLGLMVDVKQVGFYDN--------AGRIIEIPKALIAALGAVMLPRTSYLLAEGQKEK 280
Cdd:cd13137 1 RRIWSLAWPVILENLL-----QTLVGLVDVFMVGRLGAeaiaavglATQVLWLLLVLNMALGTGTVALVSQSYGAGDYER 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 281 SKYYIEVTILYVMIISSVLM-FGLISVSDIFSIIFWGEEFLESG----RLISAMSPA-FVFSVLGNIIRTQyliprakdK 354
Cdd:cd13137 76 ARRALGQSLLLALLLSLPLAlLGLLFAEPLLRLLGADPEVIALAltylRIVLLGIPFfFLSLVGNAALRGA--------G 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 355 DYVVSL---IAGAVVNLVLNYFFI------KPFGAMGATVSTVLAEFVLSGMQFWSVRRDLDLKRylkngLIFYLFGLIM 425
Cdd:cd13137 148 DTKTPMyimIIVNVLNIVLDYVLIfglwgfPGLGVAGAALATVISRVVGALLLLFLLLRGRLPIK-----ISFKGFRLDR 222
|
250 260 270
....*....|....*....|....*....|..
gi 1209454071 426 HLIIIALKTQLPYNIMSliLLIVLGGIVYVIF 457
Cdd:cd13137 223 KIIKKLLRIGLPAGLEQ--LLRSLGFLVLLAI 252
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
270-400 |
9.49e-03 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 38.26 E-value: 9.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209454071 270 SYLLAEGQKEKSKYYIEVTILYVMIISSVLM-FGLISVSDIFSIIFWGEEFLESG----RLISAMSPAFVFS-VLGNIIR 343
Cdd:cd13143 69 SRRLGAGDREKANRIFSTALLLSLILGLLLTiLGLLFLDPLLRLLGASGELLPYAvdylRIILLGAPFTILSsVLNNLLR 148
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1209454071 344 TQyliprAKDKDYVVSLIAGAVVNLVLNYFFIKPF--GAMGATVSTVLAEFVLSGMQFW 400
Cdd:cd13143 149 AE-----GKPKLAMLGMLIGAVLNIILDPLFIFVLglGIAGAALATVIAQLISLLLLLL 202
|
|
| |
