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Conserved domains on  [gi|1207186980|ref|XP_017210196|]
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zinc finger protein 239-like isoform X2 [Danio rerio]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 243-325 2.19e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 52.41  E-value: 2.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186980 243 GEKPYKCS--HCDKRFSQSSQIKLHeRIHtgekpykcSHCDKRFNQLPHLKSHERIHTGEKPYKCSHCDKRFNRLESQKR 320
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*
gi 1207186980 321 HeRTH 325
Cdd:COG5189   417 H-RKH 420
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
26-325 4.97e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 4.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186980  26 CTQCGTSLANKRNLKTHMMIHTGERPFTCSQ--CGKSFRDSSALSRHMLIHTGEKTHTCGQCGKS--FLLASGLNAHLIV 101
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLSSSSS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186980 102 HATEKPSCSVCGKSFASEVIIRRHQKIHTGVREYVCSEC-GKTFFTSTSLQQHQRIHTGEKPYICSYCDKRFSQLPylki 180
Cdd:COG5048   116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN---- 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186980 181 hkmIHTGEKPYKCSHCDKRFNNLGSLKTHERIHTGEKPYKCSHCDKRFSHLL------SLKTHESNHTGEKPYKCSHCDK 254
Cdd:COG5048   192 ---VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLlsqspsSLSSSDSSSSASESPRSSLPTA 268

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207186980 255 RFSQSSQIKLHERIHTG-EKPYKCSHCDKRFNQLPHLKSHER--IHTGE--KPYKCSH--CDKRFNRLESQKRHERTH 325
Cdd:COG5048   269 SSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346
 
Name Accession Description Interval E-value
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 243-325 2.19e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 52.41  E-value: 2.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186980 243 GEKPYKCS--HCDKRFSQSSQIKLHeRIHtgekpykcSHCDKRFNQLPHLKSHERIHTGEKPYKCSHCDKRFNRLESQKR 320
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*
gi 1207186980 321 HeRTH 325
Cdd:COG5189   417 H-RKH 420
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
26-325 4.97e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 4.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186980  26 CTQCGTSLANKRNLKTHMMIHTGERPFTCSQ--CGKSFRDSSALSRHMLIHTGEKTHTCGQCGKS--FLLASGLNAHLIV 101
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLSSSSS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186980 102 HATEKPSCSVCGKSFASEVIIRRHQKIHTGVREYVCSEC-GKTFFTSTSLQQHQRIHTGEKPYICSYCDKRFSQLPylki 180
Cdd:COG5048   116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN---- 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186980 181 hkmIHTGEKPYKCSHCDKRFNNLGSLKTHERIHTGEKPYKCSHCDKRFSHLL------SLKTHESNHTGEKPYKCSHCDK 254
Cdd:COG5048   192 ---VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLlsqspsSLSSSDSSSSASESPRSSLPTA 268

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207186980 255 RFSQSSQIKLHERIHTG-EKPYKCSHCDKRFNQLPHLKSHER--IHTGE--KPYKCSH--CDKRFNRLESQKRHERTH 325
Cdd:COG5048   269 SSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346
zf-H2C2_2 pfam13465
Zinc-finger double domain;
289-314 1.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.52e-04
                          10        20
                  ....*....|....*....|....*.
gi 1207186980 289 HLKSHERIHTGEKPYKCSHCDKRFNR 314
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
205-230 3.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 3.60e-04
                          10        20
                  ....*....|....*....|....*.
gi 1207186980 205 SLKTHERIHTGEKPYKCSHCDKRFSH 230
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 161-209 2.67e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 2.67e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1207186980 161 KPYiCSYCDKRFSQLPYLKIH-KMIHtgekpYKCSHCDKRFNNLGSLKTH 209
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHqKAKH-----FKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 243-325 2.19e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 52.41  E-value: 2.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186980 243 GEKPYKCS--HCDKRFSQSSQIKLHeRIHtgekpykcSHCDKRFNQLPHLKSHERIHTGEKPYKCSHCDKRFNRLESQKR 320
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*
gi 1207186980 321 HeRTH 325
Cdd:COG5189   417 H-RKH 420
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
26-325 4.97e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 4.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186980  26 CTQCGTSLANKRNLKTHMMIHTGERPFTCSQ--CGKSFRDSSALSRHMLIHTGEKTHTCGQCGKS--FLLASGLNAHLIV 101
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLSSSSS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186980 102 HATEKPSCSVCGKSFASEVIIRRHQKIHTGVREYVCSEC-GKTFFTSTSLQQHQRIHTGEKPYICSYCDKRFSQLPylki 180
Cdd:COG5048   116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN---- 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186980 181 hkmIHTGEKPYKCSHCDKRFNNLGSLKTHERIHTGEKPYKCSHCDKRFSHLL------SLKTHESNHTGEKPYKCSHCDK 254
Cdd:COG5048   192 ---VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLlsqspsSLSSSDSSSSASESPRSSLPTA 268

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207186980 255 RFSQSSQIKLHERIHTG-EKPYKCSHCDKRFNQLPHLKSHER--IHTGE--KPYKCSH--CDKRFNRLESQKRHERTH 325
Cdd:COG5048   269 SSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
55-322 1.36e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186980  55 SQCGKSFRDSSALSRHMLIHTGEKTHTCGQCGKSFLLASGLNAHLIVHATEKPSCSVCGKSFASEVIIRRHQKIHTGVRE 134
Cdd:COG5048   175 SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186980 135 YVCSECGKTFFTSTSLQQHQRIHTGE-------KPYICSYCDKRFSQLPYLKIHK--MIHTGE--KPYKCSH--CDKRFN 201
Cdd:COG5048   255 SSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFS 334

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186980 202 NLGSLKTHERIHTGEKPYKC--SHCDKRFSHLLSLKTHES--NHTGEKPYK---CSH--CDKRFSQSSQIKLHERIHTGE 272
Cdd:COG5048   335 RNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSlqQYKDLKNDKkseTLSnsCIRNFKRDSNLSLHIITHLSF 414

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1207186980 273 KPY--KCSHCDKRFNQLPHLKSHERIHTGEKPYKCSHCDKRFNRLESQKRHE 322
Cdd:COG5048   415 RPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 159-242 3.11e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 3.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186980 159 GEKPYICSY--CDKRFSQLPYLKIHKmihtgekpyKCSHCDKRFNNLGSLKTHERIHTGEKPYKCSHCDKRFSHLLSLKT 236
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1207186980 237 HESNHT 242
Cdd:COG5189   417 HRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
189-343 5.95e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 5.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186980 189 KPYKCSHCDKRFNNLGSLKTHER--IHTGE--KPYKCSH--CDKRFSHLLSLKTHESNHTGEKPYKC--SHCDKRFSQSS 260
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186980 261 QIKLHERIH-----TGEKPYKCSH--CDKRFNQLPHLKSHERIHTGEKPY--KCSHCDKRFNRLESQKRHERTHNGETQV 331
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|..
gi 1207186980 332 RFSQSETLNNTQ 343
Cdd:COG5048   448 LCSILKSFRRDL 459
zf-H2C2_2 pfam13465
Zinc-finger double domain;
289-314 1.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.52e-04
                          10        20
                  ....*....|....*....|....*.
gi 1207186980 289 HLKSHERIHTGEKPYKCSHCDKRFNR 314
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
205-230 3.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 3.60e-04
                          10        20
                  ....*....|....*....|....*.
gi 1207186980 205 SLKTHERIHTGEKPYKCSHCDKRFSH 230
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
161-288 4.24e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 4.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186980 161 KPYICSYCDKRFSQLPYLKIHKMIHTGEKPYKCSH--CDKRFNNLGSLKTHERIHTGEKPYKCSHCdkrFSHLLSLKTHE 238
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKS---LPLSNSKASSS 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1207186980 239 SNHTgekpykCSHCDKRFSQSSQIKLHERIHTGEKPYKCSHCDKRFNQLP 288
Cdd:COG5048   109 SLSS------SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLP 152
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
273-341 8.88e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 8.88e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207186980 273 KPYKCSHCDKRFNQLPHLKSHERIHTGEKPYKCSH--CDKRFNRLESQKRHERTHNGETQVRFSQSETLNN 341
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSN 102
zf-H2C2_2 pfam13465
Zinc-finger double domain;
38-61 1.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.89e-03
                          10        20
                  ....*....|....*....|....
gi 1207186980  38 NLKTHMMIHTGERPFTCSQCGKSF 61
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
263-286 2.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.49e-03
                          10        20
                  ....*....|....*....|....
gi 1207186980 263 KLHERIHTGEKPYKCSHCDKRFNQ 286
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
177-202 2.54e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.54e-03
                          10        20
                  ....*....|....*....|....*.
gi 1207186980 177 YLKIHKMIHTGEKPYKCSHCDKRFNN 202
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 161-209 2.67e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 2.67e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1207186980 161 KPYiCSYCDKRFSQLPYLKIH-KMIHtgekpYKCSHCDKRFNNLGSLKTH 209
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHqKAKH-----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
149-174 3.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 3.80e-03
                          10        20
                  ....*....|....*....|....*.
gi 1207186980 149 SLQQHQRIHTGEKPYICSYCDKRFSQ 174
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
233-258 4.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.58e-03
                          10        20
                  ....*....|....*....|....*.
gi 1207186980 233 SLKTHESNHTGEKPYKCSHCDKRFSQ 258
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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