NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1205914884|ref|NP_001339359|]
View 

RCC1 and BTB domain-containing protein 2 isoform 6 [Homo sapiens]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 76-263 8.68e-45

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 155.13  E-value: 8.68e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914884  76 GTNCCGCLGLGDVQSTIEPRRLDSLNG-KKIAClsyGSGpHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNL 154
Cdd:COG5184    73 GNNSYGQLGDGTTTDRTTPVKVPGLTGvVAVAA---GYY-HSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914884 155 SNkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGcLQNkvVVTIACGQMCCMAVVDTGEVYVW 234
Cdd:COG5184   149 SG--VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGG-LSG--VVAVAAGGDHSCALKSDGTVWCW 223

                         170       180
                  ....*....|....*....|....*....
gi 1205914884 235 GYNGNGQLGLGNSGNQPTPCRVAALQGIR 263
Cdd:COG5184   224 GSNSSGQLGDGTTTDRATPVQVAGLTGVV 252
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 76-263 8.68e-45

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 155.13  E-value: 8.68e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914884  76 GTNCCGCLGLGDVQSTIEPRRLDSLNG-KKIAClsyGSGpHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNL 154
Cdd:COG5184    73 GNNSYGQLGDGTTTDRTTPVKVPGLTGvVAVAA---GYY-HSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914884 155 SNkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGcLQNkvVVTIACGQMCCMAVVDTGEVYVW 234
Cdd:COG5184   149 SG--VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGG-LSG--VVAVAAGGDHSCALKSDGTVWCW 223

                         170       180
                  ....*....|....*....|....*....
gi 1205914884 235 GYNGNGQLGLGNSGNQPTPCRVAALQGIR 263
Cdd:COG5184   224 GSNSSGQLGDGTTTDRATPVQVAGLTGVV 252
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
175-225 2.33e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 63.31  E-value: 2.33e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1205914884 175 DGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKvVVTIACGQMCCMAV 225
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNK-VVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 76-263 8.68e-45

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 155.13  E-value: 8.68e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914884  76 GTNCCGCLGLGDVQSTIEPRRLDSLNG-KKIAClsyGSGpHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNL 154
Cdd:COG5184    73 GNNSYGQLGDGTTTDRTTPVKVPGLTGvVAVAA---GYY-HSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914884 155 SNkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGcLQNkvVVTIACGQMCCMAVVDTGEVYVW 234
Cdd:COG5184   149 SG--VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGG-LSG--VVAVAAGGDHSCALKSDGTVWCW 223

                         170       180
                  ....*....|....*....|....*....
gi 1205914884 235 GYNGNGQLGLGNSGNQPTPCRVAALQGIR 263
Cdd:COG5184   224 GSNSSGQLGDGTTTDRATPVQVAGLTGVV 252
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 76-253 8.70e-42

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 147.05  E-value: 8.70e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914884  76 GTNCCGCLGLGDVQSTIEPRRLDSLNGkkIACLSYGSGpHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTnLS 155
Cdd:COG5184   174 GANSYGQLGDGTTTDRPTPVQVGGLSG--VVAVAAGGD-HSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAG-LT 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914884 156 NkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGcLQNkvVVTIACGQMCCMAVVDTGEVYVWG 235
Cdd:COG5184   250 G--VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPG-LSG--VVAVAAGSSHTCALLTDGTVWCWG 324

                         170
                  ....*....|....*...
gi 1205914884 236 YNGNGQLGLGNSGNQPTP 253
Cdd:COG5184   325 DNAYGQLGDGTTTDRSTP 342
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 76-263 2.88e-40

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 143.19  E-value: 2.88e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914884  76 GTNCCGCLGLGDVQSTIEPRRLDSLNG-KKIAClsyGSGpHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIStNL 154
Cdd:COG5184    23 GDNSYGQLGDGTTTDRSTPVRVPGLSNvVAVAA---GGD-HTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVP-GL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914884 155 SNkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNkvVVTIACGQMCCMAVVDTGEVYVW 234
Cdd:COG5184    98 TG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG--VVAIAAGGYHTCALKSDGTVWCW 173

                         170       180
                  ....*....|....*....|....*....
gi 1205914884 235 GYNGNGQLGLGNSGNQPTPCRVAALQGIR 263
Cdd:COG5184   174 GANSYGQLGDGTTTDRPTPVQVGGLSGVV 202
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 76-263 1.96e-39

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 140.88  E-value: 1.96e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914884  76 GTNCCGCLGLGDVQSTIEPRRLDsLNGKKIACLSYGSGpHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTnLS 155
Cdd:COG5184   123 GDNSSGQLGDGTTTNRLTPVQVD-AGLSGVVAIAAGGY-HTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGG-LS 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914884 156 NkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGcLQNkvVVTIACGQMCCMAVVDTGEVYVWG 235
Cdd:COG5184   200 G--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAG-LTG--VVAIAAGGSHTCALKSDGTVWCWG 274

                         170       180
                  ....*....|....*....|....*...
gi 1205914884 236 YNGNGQLGLGNSGNQPTPCRVAALQGIR 263
Cdd:COG5184   275 DNSYGQLGDGTTTDRSTPVKVPGLSGVV 302
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 115-258 2.53e-37

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 135.49  E-value: 2.53e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914884 115 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIStNLSNkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGST 194
Cdd:COG5184     9 HSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVP-GLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTT 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1205914884 195 VNQPIPRRVTGclqNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAA 258
Cdd:COG5184    86 TDRTTPVKVPG---LTGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDA 146
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 160-263 4.64e-26

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 105.06  E-value: 4.64e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914884 160 IEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGcLQNkvVVTIACGQMCCMAVVDTGEVYVWGYNGN 239
Cdd:COG5184     1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPG-LSN--VVAVAAGGDHTCALKADGTVWCWGNNSY 77

                          90       100
                  ....*....|....*....|....
gi 1205914884 240 GQLGLGNSGNQPTPCRVAALQGIR 263
Cdd:COG5184    78 GQLGDGTTTDRTTPVKVPGLTGVV 101
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
175-225 2.33e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 63.31  E-value: 2.33e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1205914884 175 DGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKvVVTIACGQMCCMAV 225
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNK-VVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
122-172 2.68e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 60.22  E-value: 2.68e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1205914884 122 EGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKqVIEVACGSYHSLVL 172
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNK-VVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
159-188 3.72e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 53.97  E-value: 3.72e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 1205914884 159 VIEVACGSYHSLVLTSDGEVFAWGYNNSGQ 188
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
229-267 4.46e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 51.36  E-value: 4.46e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1205914884 229 GEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRV 267
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQV 40
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
212-241 1.87e-03

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 35.09  E-value: 1.87e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1205914884 212 VVTIACGQMCCMAVVDTGEVYVWGYNGNGQ 241
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH