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Conserved domains on  [gi|12003207|gb|AAG43485|]
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NS1-binding protein-like protein [Homo sapiens]

Protein Classification

kelch-like protein; kelch-like protein 12( domain architecture ID 13033714)

kelch-like protein may act as substrate adaptors for Cullin 3 ubiquitin ligases; kelch-like protein 12 (KLHL12) is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-137 7.11e-76

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 237.93  E-value: 7.11e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  14 FIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTA 93
Cdd:cd18306   1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 12003207  94 QLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISY 137
Cdd:cd18306  81 RLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
349-627 3.86e-57

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 194.22  E-value: 3.86e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 349 KPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPM-RTPRARFQMAVLMGQLYVVGGSNGHS 427
Cdd:COG3055   4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGAN 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 428 DDLSC---GEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGqkGLKNCDVFDPVTKLWTSCAPL-NIRRH 503
Cdd:COG3055  84 PSSTPlndVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG--NVAWVEVYDPATGTWTQLAPLpTPRDH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 504 QSAVCELGGYLYIIGGAeswnclntveRYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAIscVEMYDPTR 583
Cdd:COG3055 162 LAAAVLPDGKILVIGGR----------NGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDE--VEAYDPAT 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 12003207 584 NEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGN----EFLNTVEVYN 627
Cdd:COG3055 230 NTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPgvrtPLVTSAEVYD 277
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 129-225 1.11e-43

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


:

Pssm-ID: 350577  Cd Length: 99  Bit Score: 151.62  E-value: 1.11e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 129 MDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDNVCLPS--NGKLYTKVINWVQRSI 206
Cdd:cd18502   1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQIEVILESNQELESinERKLCQLVLEWVQRSI 80

                        90
                ....*....|....*....
gi 12003207 207 WENGDSLEELMEEVQTLYY 225
Cdd:cd18502  81 EEGGLDLDDLTEKVHMLYL 99
 
Name Accession Description Interval E-value
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-137 7.11e-76

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 237.93  E-value: 7.11e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  14 FIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTA 93
Cdd:cd18306   1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 12003207  94 QLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISY 137
Cdd:cd18306  81 RLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
349-627 3.86e-57

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 194.22  E-value: 3.86e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 349 KPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPM-RTPRARFQMAVLMGQLYVVGGSNGHS 427
Cdd:COG3055   4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGAN 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 428 DDLSC---GEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGqkGLKNCDVFDPVTKLWTSCAPL-NIRRH 503
Cdd:COG3055  84 PSSTPlndVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG--NVAWVEVYDPATGTWTQLAPLpTPRDH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 504 QSAVCELGGYLYIIGGAeswnclntveRYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAIscVEMYDPTR 583
Cdd:COG3055 162 LAAAVLPDGKILVIGGR----------NGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDE--VEAYDPAT 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 12003207 584 NEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGN----EFLNTVEVYN 627
Cdd:COG3055 230 NTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPgvrtPLVTSAEVYD 277
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 129-225 1.11e-43

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 151.62  E-value: 1.11e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 129 MDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDNVCLPS--NGKLYTKVINWVQRSI 206
Cdd:cd18502   1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQIEVILESNQELESinERKLCQLVLEWVQRSI 80

                        90
                ....*....|....*....
gi 12003207 207 WENGDSLEELMEEVQTLYY 225
Cdd:cd18502  81 EEGGLDLDDLTEKVHMLYL 99
PHA03098 PHA03098
kelch-like protein; Provisional
 23-638 1.36e-43

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 164.17  E-value: 1.36e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207   23 NALRKSGQFCDVRLQVC--GHEMLAHRAVLACCSPYLFEIFNSDSDPHGIShVKFDDlnpEAVEVLLNYAYTAQLKADKE 100
Cdd:PHA03098   1 MYSFELQKFCDESIIIVngGGIIKVHKIILSSSSEYFKKMFKNNFKENEIN-LNIDY---DSFNEVIKYIYTGKINITSN 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  101 LVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEV 180
Cdd:PHA03098  77 NVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIK 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  181 ML---------EDNVCLpsngklytKVINWVQRSIWENGDSLEELMEEVQTLYYSAD--HKLldgnlldgqaevfgsddd 249
Cdd:PHA03098 157 ILsddklnvssEDVVLE--------IIIKWLTSKKNNKYKDICLILKVLRITFLSEEgiKKL------------------ 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  250 hiqfvqKKPPRENGHKQISSSStgclsspnatvQSPKHewkIVASEKTSNNTYLclavldgifcviflhgrnspqssptS 329
Cdd:PHA03098 211 ------KRWKLRIKKKKIVFNK-----------RCIKI---IYSKKYNLNKILP-------------------------R 245

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  330 TPKLSKSLSFEMQQDEliekpmSPMQYArsglgtaemngkliaaggynreeclrtveCYNPHTDHWSFLAPmRTPRARFQ 409
Cdd:PHA03098 246 SSTFGSIIYIHITMSI------FTYNYI-----------------------------TNYSPLSEINTIID-IHYVYCFG 289

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  410 MAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSdpYGQKGLKNCDVFDPVT 489
Cdd:PHA03098 290 SVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGI--YNSISLNTVESWKPGE 367

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  490 KLWTSCAPLNIRRHQSAVCELGGYLYIIGGA-ESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGF- 567
Cdd:PHA03098 368 SKWREEPPLIFPRYNPCVVNVNNLIYVIGGIsKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIs 447

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12003207  568 --DGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTK 638
Cdd:PHA03098 448 yiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCK 520
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 22-127 1.18e-28

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 110.04  E-value: 1.18e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207    22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLkADKEL 101
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*.
gi 12003207   102 VKDVYSAAKKLKMDRVKQVCGDYLLS 127
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIK 105
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 33-128 2.10e-22

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 91.98  E-value: 2.10e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207     33 DVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKL 112
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*.
gi 12003207    113 KMDRVKQVCGDYLLSR 128
Cdd:smart00225  81 QIPGLVELCEEFLLKL 96
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 134-229 8.30e-18

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 78.92  E-value: 8.30e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207    134 CISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLE-DNVCLPSNGKLYTKVINWVQRSIWENGDS 212
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSsDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90
                   ....*....|....*..
gi 12003207    213 LEELMEEVQTLYYSADH 229
Cdd:smart00875  81 LPELLEHVRLPLLSPDY 97
Kelch smart00612
Kelch domain;
514-559 1.20e-14

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 68.35  E-value: 1.20e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 12003207    514 LYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNG 559
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 595-635 2.98e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 64.17  E-value: 2.98e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 12003207   595 PRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSP 635
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSK 41
PLN02153 PLN02153
epithiospecifier protein
 404-613 8.39e-13

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 70.02  E-value: 8.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  404 PRARFQMAVLMGQLYVVGGS---NGHSD-DLScgeMYDSNIDDWIPVPE----LRTNRCNAGVCALNGKLYIVGGSDPyg 475
Cdd:PLN02153  22 PRCSHGIAVVGDKLYSFGGElkpNEHIDkDLY---VFDFNTHTWSIAPAngdvPRISCLGVRMVAVGTKLYIFGGRDE-- 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  476 QKGLKNCDVFDPVTKLWTSCAPLNIR-----RHQSAVCELGGYLYIIGGAESWNCLNTVER------YNPENNTWT-LIA 543
Cdd:PLN02153  97 KREFSDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGVSKGGLMKTPERfrtieaYNIADGKWVqLPD 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  544 P-MNVARRG-AGVAVLNGKLFVCGGFDGS--------HAISCVEMYDPTRNEW---KMMGNMTSPRSNAGIATVGNTIYA 610
Cdd:PLN02153 177 PgENFEKRGgAGFAVVQGKIWVVYGFATSilpggksdYESNAVQFFDPASGKWtevETTGAKPSARSVFAHAVVGKYIII 256


                 ...
gi 12003207  611 VGG 613
Cdd:PLN02153 257 FGG 259
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 134-220 4.55e-10

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 57.17  E-value: 4.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207   134 CISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLE-DNVCLPSNGKLYTKVINWVQRSIWENGDS 212
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSsDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80


                  ....*...
gi 12003207   213 LEELMEEV 220
Cdd:pfam07707  81 LPELLSAV 88
 
Name Accession Description Interval E-value
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-137 7.11e-76

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 237.93  E-value: 7.11e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  14 FIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTA 93
Cdd:cd18306   1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 12003207  94 QLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISY 137
Cdd:cd18306  81 RLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
349-627 3.86e-57

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 194.22  E-value: 3.86e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 349 KPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPM-RTPRARFQMAVLMGQLYVVGGSNGHS 427
Cdd:COG3055   4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGAN 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 428 DDLSC---GEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGqkGLKNCDVFDPVTKLWTSCAPL-NIRRH 503
Cdd:COG3055  84 PSSTPlndVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG--NVAWVEVYDPATGTWTQLAPLpTPRDH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 504 QSAVCELGGYLYIIGGAeswnclntveRYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAIscVEMYDPTR 583
Cdd:COG3055 162 LAAAVLPDGKILVIGGR----------NGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDE--VEAYDPAT 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 12003207 584 NEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGN----EFLNTVEVYN 627
Cdd:COG3055 230 NTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPgvrtPLVTSAEVYD 277
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
442-634 2.13e-48

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 170.72  E-value: 2.13e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 442 DWIPVPELRTNRCNAGVCALNGKLYIVGGSDpyGQKGLKNCDVFDPVTKLWTSCAPLNI-RRHQSAVCELGGYLYIIGG- 519
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLS--GGSASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGf 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 520 ---AESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPR 596
Cdd:COG3055  80 tgaNPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPR 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12003207 597 SNAGIATVGN-TIYAVGGFDG-----------------------------------NEFLNTVEVYNLESNEWS 634
Cdd:COG3055 160 DHLAAAVLPDgKILVIGGRNGsgfsntwttlaplptaraghaaavlggkilvfggeSGFSDEVEAYDPATNTWT 233
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 129-225 1.11e-43

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 151.62  E-value: 1.11e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 129 MDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDNVCLPS--NGKLYTKVINWVQRSI 206
Cdd:cd18502   1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQIEVILESNQELESinERKLCQLVLEWVQRSI 80

                        90
                ....*....|....*....
gi 12003207 207 WENGDSLEELMEEVQTLYY 225
Cdd:cd18502  81 EEGGLDLDDLTEKVHMLYL 99
PHA03098 PHA03098
kelch-like protein; Provisional
 23-638 1.36e-43

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 164.17  E-value: 1.36e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207   23 NALRKSGQFCDVRLQVC--GHEMLAHRAVLACCSPYLFEIFNSDSDPHGIShVKFDDlnpEAVEVLLNYAYTAQLKADKE 100
Cdd:PHA03098   1 MYSFELQKFCDESIIIVngGGIIKVHKIILSSSSEYFKKMFKNNFKENEIN-LNIDY---DSFNEVIKYIYTGKINITSN 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  101 LVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEV 180
Cdd:PHA03098  77 NVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIK 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  181 ML---------EDNVCLpsngklytKVINWVQRSIWENGDSLEELMEEVQTLYYSAD--HKLldgnlldgqaevfgsddd 249
Cdd:PHA03098 157 ILsddklnvssEDVVLE--------IIIKWLTSKKNNKYKDICLILKVLRITFLSEEgiKKL------------------ 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  250 hiqfvqKKPPRENGHKQISSSStgclsspnatvQSPKHewkIVASEKTSNNTYLclavldgifcviflhgrnspqssptS 329
Cdd:PHA03098 211 ------KRWKLRIKKKKIVFNK-----------RCIKI---IYSKKYNLNKILP-------------------------R 245

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  330 TPKLSKSLSFEMQQDEliekpmSPMQYArsglgtaemngkliaaggynreeclrtveCYNPHTDHWSFLAPmRTPRARFQ 409
Cdd:PHA03098 246 SSTFGSIIYIHITMSI------FTYNYI-----------------------------TNYSPLSEINTIID-IHYVYCFG 289

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  410 MAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSdpYGQKGLKNCDVFDPVT 489
Cdd:PHA03098 290 SVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGI--YNSISLNTVESWKPGE 367

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  490 KLWTSCAPLNIRRHQSAVCELGGYLYIIGGA-ESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGF- 567
Cdd:PHA03098 368 SKWREEPPLIFPRYNPCVVNVNNLIYVIGGIsKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIs 447

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12003207  568 --DGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTK 638
Cdd:PHA03098 448 yiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCK 520
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
492-635 1.02e-37

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 141.45  E-value: 1.02e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 492 WTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARR-GAGVAVLNGKLFVCGGFDGS 570
Cdd:COG3055   3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRhHAAAVAQDGKLYVFGGFTGA 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12003207 571 HAISC----VEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSP 635
Cdd:COG3055  83 NPSSTplndVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQ 151
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 22-127 1.18e-28

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 110.04  E-value: 1.18e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207    22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLkADKEL 101
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*.
gi 12003207   102 VKDVYSAAKKLKMDRVKQVCGDYLLS 127
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIK 105
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-134 6.29e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 102.90  E-value: 6.29e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKE 100
Cdd:cd18242  11 TMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTETVHVTVE 90

                        90       100       110
                ....*....|....*....|....*....|....
gi 12003207 101 LVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSC 134
Cdd:cd18242  91 NVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-112 5.10e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 98.78  E-value: 5.10e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  31 FCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAK 110
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80


                ..
gi 12003207 111 KL 112
Cdd:cd18186  81 KL 82
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-135 4.40e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 94.86  E-value: 4.40e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18237  12 MNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISVNSNN 91

                        90       100       110
                ....*....|....*....|....*....|....
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCI 135
Cdd:cd18237  92 VQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-130 9.46e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 93.65  E-value: 9.46e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  18 SVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKA 97
Cdd:cd18235   8 AFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTAEIQV 87

                        90       100       110
                ....*....|....*....|....*....|...
gi 12003207  98 DKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMD 130
Cdd:cd18235  88 TEENVQVLLPAANLLQLTDVRDACCDFLQSQLH 120
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 33-128 2.10e-22

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 91.98  E-value: 2.10e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207     33 DVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKL 112
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*.
gi 12003207    113 KMDRVKQVCGDYLLSR 128
Cdd:smart00225  81 QIPGLVELCEEFLLKL 96
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-136 2.16e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 92.74  E-value: 2.16e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18238   6 LHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTLTVDN 85

                        90       100       110
                ....*....|....*....|....*....|....*
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCIS 136
Cdd:cd18238  86 VQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-135 1.69e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 87.46  E-value: 1.69e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  20 AKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADK 99
Cdd:cd18256   9 AQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEVTV 88

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 12003207 100 ELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCI 135
Cdd:cd18256  89 SNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCI 124
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-128 2.14e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 86.95  E-value: 2.14e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18247  10 MEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGRIAIDTSN 89

                        90       100
                ....*....|....*....|....*..
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYLLSR 128
Cdd:cd18247  90 VQSLLVGASFLQLQSVKDACCEFLKER 116
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-134 2.57e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 87.00  E-value: 2.57e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18240   8 FNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPITAEN 87

                        90       100       110
                ....*....|....*....|....*....|...
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSC 134
Cdd:cd18240  88 VEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-135 3.01e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 87.19  E-value: 3.01e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18259  23 LQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYTGKLTINQGN 102

                        90       100       110
                ....*....|....*....|....*....|....
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCI 135
Cdd:cd18259 103 VEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCL 136
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-130 1.48e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 85.47  E-value: 1.48e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  18 SVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKA 97
Cdd:cd18246  26 AFVSMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIVV 105

                        90       100       110
                ....*....|....*....|....*....|...
gi 12003207  98 DKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMD 130
Cdd:cd18246 106 GEGNVQTLLPAASLLQLNGVRDACCKFLLSQLD 138
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-134 7.05e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 82.83  E-value: 7.05e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18255   9 LNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSELTLDLDC 88

                        90       100       110
                ....*....|....*....|....*....|...
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSC 134
Cdd:cd18255  89 IQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-131 9.64e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 82.20  E-value: 9.64e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18257   9 LNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQAT 88

                        90       100       110
                ....*....|....*....|....*....|
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYLLSRMDV 131
Cdd:cd18257  89 VESLLPAANLLQIKLVLKECCDFLESQLDP 118
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-127 3.32e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 81.06  E-value: 3.32e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  18 SVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIF----------NSDSDPHGIS--HVKFDDLNPeavev 85
Cdd:cd18228   6 LLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLvgqasprlvlVSPAGKCVLDlhHVTVTGFAP----- 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 12003207  86 LLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLS 127
Cdd:cd18228  81 LLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKS 122
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-136 8.07e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 80.25  E-value: 8.07e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207   9 FEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLA--------HRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNP 80
Cdd:cd18273   4 LEDAAHARALLAQLKSFYDARLLTDVTIEVNGPGSGPgsgrlfpcNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDS 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 12003207  81 EAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCIS 136
Cdd:cd18273  84 ESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVG 139
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 134-229 8.30e-18

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 78.92  E-value: 8.30e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207    134 CISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLE-DNVCLPSNGKLYTKVINWVQRSIWENGDS 212
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSsDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90
                   ....*....|....*..
gi 12003207    213 LEELMEEVQTLYYSADH 229
Cdd:smart00875  81 LPELLEHVRLPLLSPDY 97
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-135 2.59e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 78.65  E-value: 2.59e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  17 SSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLK 96
Cdd:cd18249   9 QTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYTSQIT 88

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 12003207  97 ADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCI 135
Cdd:cd18249  89 VEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCL 127
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-125 3.38e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 78.05  E-value: 3.38e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  19 VAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDS--DPHGISHVKFddLNPEAVEVLLNYAYTAQLK 96
Cdd:cd18326  13 LSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAvvDQQNVYEIDF--VSAEALTALLDFAYTATLT 90

                        90       100
                ....*....|....*....|....*....
gi 12003207  97 ADKELVKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18326  91 VSTSNVGDILSAARLLEIPAVSHVCADLL 119
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-135 5.29e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 78.11  E-value: 5.29e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207   8 MFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDD-LNPEAVEVL 86
Cdd:cd18267  17 LFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHDsIHPEVLELL 96

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 12003207  87 LNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCI 135
Cdd:cd18267  97 LDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCL 145
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-129 7.97e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 77.07  E-value: 7.97e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18339  12 MNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEEN 91

                        90       100
                ....*....|....*....|....*...
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYLLSRM 129
Cdd:cd18339  92 VQVLLPAASLLQLMDVRQNCCDFLQSQL 119
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-138 9.33e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 77.01  E-value: 9.33e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  13 NFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYT 92
Cdd:cd18336   1 NHAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYT 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 12003207  93 AQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYR 138
Cdd:cd18336  81 GVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGIR 126
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-135 1.63e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 76.40  E-value: 1.63e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALR---KSGQFCDVRLQVCGHEML-AHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKA 97
Cdd:cd18252   9 LDAFRtfyLDGLFTDITLQCASGQIFhCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICI 88

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 12003207  98 DKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCI 135
Cdd:cd18252  89 TERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCL 126
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-136 1.70e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 76.41  E-value: 1.70e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18340  18 LKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQN 97

                        90       100       110
                ....*....|....*....|....*....|....*
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCIS 136
Cdd:cd18340  98 VQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLA 132
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-136 2.58e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 75.90  E-value: 2.58e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18269  18 LKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQN 97

                        90       100       110
                ....*....|....*....|....*....|....*
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCIS 136
Cdd:cd18269  98 VQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCLA 132
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-125 3.43e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 74.90  E-value: 3.43e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18198  16 LNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLEFAYTATLTVSTAN 95

                        90       100
                ....*....|....*....|....
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18198  96 VGDILSAARLLEIPCVSHVCAEIL 119
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-130 7.44e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 74.34  E-value: 7.44e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  11 DENFIESSVAKLNALRKSGQFCDVRLQVCGH----EMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVL 86
Cdd:cd18248   1 LEDHTKEAFQIMNELRLSQQLCDVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 12003207  87 LNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMD 130
Cdd:cd18248  81 IEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQLD 124
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-123 1.25e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 73.29  E-value: 1.25e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHV-KFDDLNPEAVEVLLNYAYTAQLKADK 99
Cdd:cd18293   5 QLHRQQNSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAGQKVVlELQGLKAHTLLKLVDFLYTSELEVSS 84

                        90       100
                ....*....|....*....|....
gi 12003207 100 ELVKDVYSAAKKLKMDRVKQVCGD 123
Cdd:cd18293  85 EEAQDVLAAARRLQISELESLCLE 108
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-125 1.59e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 72.76  E-value: 1.59e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFN-----SDSDPHGISHvkfDDLNPEAVEVLLNYAYTAQLK 96
Cdd:cd18245   5 LNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNynppkDDGSTYKIEL---EGISVEVMEEILDYIYTGQIK 81

                        90       100
                ....*....|....*....|....*....
gi 12003207  97 ADKELVKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18245  82 LSEDNIQDIVQAADLLLMTDLKDLCCEFL 110
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-134 1.86e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 73.26  E-value: 1.86e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18250  12 LSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTGRVTVTQDN 91

                        90       100       110
                ....*....|....*....|....*....|...
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSC 134
Cdd:cd18250  92 VEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-121 4.12e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 71.84  E-value: 4.12e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18328  16 LNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAILEFAYTSTLTITTSN 95

                        90       100
                ....*....|....*....|
gi 12003207 102 VKDVYSAAKKLKMDRVKQVC 121
Cdd:cd18328  96 VKHILNAAQMLEIQCIINVC 115
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-129 4.41e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 72.03  E-value: 4.41e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18338  12 MNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEEN 91

                        90       100
                ....*....|....*....|....*...
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYLLSRM 129
Cdd:cd18338  92 VQVLLPAAGLLQLQDVKKTCCEFLESQL 119
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-136 5.47e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 72.19  E-value: 5.47e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18341  18 LKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDLNDGN 97

                        90       100       110
                ....*....|....*....|....*....|....*
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCIS 136
Cdd:cd18341  98 VQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLA 132
Kelch smart00612
Kelch domain;
514-559 1.20e-14

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 68.35  E-value: 1.20e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 12003207    514 LYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNG 559
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-134 1.29e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 70.63  E-value: 1.29e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  16 ESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQL 95
Cdd:cd18253   3 ESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKV 82

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 12003207  96 KADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSC 134
Cdd:cd18253  83 KITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-135 2.34e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 70.22  E-value: 2.34e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKE 100
Cdd:cd18276  11 QLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSSDLHLTNS 90

                        90       100       110
                ....*....|....*....|....*....|....*
gi 12003207 101 LVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCI 135
Cdd:cd18276  91 NVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCL 125
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-135 2.51e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 69.80  E-value: 2.51e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18265  14 LNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDN 93

                        90       100       110
                ....*....|....*....|....*....|....
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCI 135
Cdd:cd18265  94 VESVLEASDLLQVSKLREACVRFLEGQLHPCNCL 127
Kelch smart00612
Kelch domain;
560-606 2.52e-14

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 67.20  E-value: 2.52e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 12003207    560 KLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGN 606
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-135 9.17e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 68.50  E-value: 9.17e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  16 ESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKF-DDLNPEAVEVLLNYAYTAQ 94
Cdd:cd18254   7 DCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFhDSLHPEVLELLLDFAYSSR 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 12003207  95 LKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCI 135
Cdd:cd18254  87 IIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 127
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-121 1.33e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 67.59  E-value: 1.33e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFnSDSDPHGISHVKFD-DLNPEAVEVLLNYAYTAQLKADKE 100
Cdd:cd18215  10 LNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIF-TDQLKNNVSVINLDpEIEPEGFRILLDFMYTSRLNLREG 88

                        90       100
                ....*....|....*....|.
gi 12003207 101 LVKDVYSAAKKLKMDRVKQVC 121
Cdd:cd18215  89 NIMAVMATAMYLQMEHVVDTC 109
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-139 1.59e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 67.90  E-value: 1.59e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207   6 YLMFEDENFiESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEV 85
Cdd:cd18264   4 FLAYSKSHG-EAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQR 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 12003207  86 LLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRN 139
Cdd:cd18264  83 VLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENCCFSAN 136
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-125 1.68e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 67.56  E-value: 1.68e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHV-------KFDDLNPEAVEVLLNYAYTAQ 94
Cdd:cd18327  16 LNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAgggqdvcELDFVGPEALGALLEFAYTAT 95

                        90       100       110
                ....*....|....*....|....*....|.
gi 12003207  95 LKADKELVKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18327  96 LTISSSNMREVLRAARLLEIPCVADACADIL 126
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-135 1.77e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 66.62  E-value: 1.77e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  32 CDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKK 111
Cdd:cd18234   2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACL 81

                        90       100
                ....*....|....*....|....
gi 12003207 112 LKMDRVKQVCGDYLLSRMDVTSCI 135
Cdd:cd18234  82 LQLSEVVEACCGFLMKQLHPSNCL 105
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 595-635 2.98e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 64.17  E-value: 2.98e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 12003207   595 PRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSP 635
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSK 41
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-135 3.87e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 66.95  E-value: 3.87e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  31 FCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAK 110
Cdd:cd18270  26 LTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAINDSTVEQLYETAC 105

                        90       100
                ....*....|....*....|....*
gi 12003207 111 KLKMDRVKQVCGDYLLSRMDVTSCI 135
Cdd:cd18270 106 FLQVEDVLQRCREYLIKKINAENCV 130
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-121 4.69e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 66.53  E-value: 4.69e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSG-QFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGIS-HVKFDDLNPEAVEVLLNYAYTAQLKAD 98
Cdd:cd18207  16 NLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPrELEMHTISSKVFGDILDFAYTSRIVVR 95

                        90       100
                ....*....|....*....|...
gi 12003207  99 KELVKDVYSAAKKLKMDRVKQVC 121
Cdd:cd18207  96 LESFPELMTAAKFLLMRSVIDIC 118
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-135 5.06e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 65.99  E-value: 5.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDphgISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18260   9 LNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPS---LQRVELNDISPLGLATVITYAYTGKLTLSLYT 85

                        90       100       110
                ....*....|....*....|....*....|....
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCI 135
Cdd:cd18260  86 IGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-135 5.31e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 66.16  E-value: 5.31e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  17 SSVAKLNALRKSGQFCDVRLQV-CGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQL 95
Cdd:cd18274   8 SILQQLKAMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYTSRV 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 12003207  96 KADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCI 135
Cdd:cd18274  88 TLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSI 127
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-135 6.01e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 66.01  E-value: 6.01e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18271  15 LQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITDDN 94

                        90       100       110
                ....*....|....*....|....*....|....
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCI 135
Cdd:cd18271  95 VEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCL 128
PLN02153 PLN02153
epithiospecifier protein
 404-613 8.39e-13

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 70.02  E-value: 8.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  404 PRARFQMAVLMGQLYVVGGS---NGHSD-DLScgeMYDSNIDDWIPVPE----LRTNRCNAGVCALNGKLYIVGGSDPyg 475
Cdd:PLN02153  22 PRCSHGIAVVGDKLYSFGGElkpNEHIDkDLY---VFDFNTHTWSIAPAngdvPRISCLGVRMVAVGTKLYIFGGRDE-- 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  476 QKGLKNCDVFDPVTKLWTSCAPLNIR-----RHQSAVCELGGYLYIIGGAESWNCLNTVER------YNPENNTWT-LIA 543
Cdd:PLN02153  97 KREFSDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGVSKGGLMKTPERfrtieaYNIADGKWVqLPD 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  544 P-MNVARRG-AGVAVLNGKLFVCGGFDGS--------HAISCVEMYDPTRNEW---KMMGNMTSPRSNAGIATVGNTIYA 610
Cdd:PLN02153 177 PgENFEKRGgAGFAVVQGKIWVVYGFATSilpggksdYESNAVQFFDPASGKWtevETTGAKPSARSVFAHAVVGKYIII 256


                 ...
gi 12003207  611 VGG 613
Cdd:PLN02153 257 FGG 259
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-121 8.46e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 65.16  E-value: 8.46e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  18 SVAKLNAL---RKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFddlnPEAVEVLLNYAYTAQ 94
Cdd:cd18232   2 SVKVLQALnkqREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESF----AEVFGLLLDFFYTGE 77

                        90       100
                ....*....|....*....|....*..
gi 12003207  95 LKADKELVKDVYSAAKKLKMDRVKQVC 121
Cdd:cd18232  78 LALTRENRDRVLLAAKELRVPEAVELC 104
Kelch smart00612
Kelch domain;
369-415 9.72e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 62.96  E-value: 9.72e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 12003207    369 KLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMG 415
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-128 1.27e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 65.23  E-value: 1.27e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  14 FIESSVAKLNALRKS---GQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYA 90
Cdd:cd18323   3 FPDHSRHLLQSLREQrhqGFLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKEQLDKRDLVCINNEIVTAPAFSLLLEFM 82

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 12003207  91 YTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSR 128
Cdd:cd18323  83 YEGRLSFNDTPVEDVLAAASYLHMNDIVKVCKKRLQAR 120
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-125 1.29e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 64.97  E-value: 1.29e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDpHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18278  22 LNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTE-NDLVVSLPEEVTARGFGPLLQFAYTAKLLLSREN 100

                        90       100
                ....*....|....*....|....
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18278 101 IQEVIRCAEFLRMHNLEDSCFRFL 124
PHA02790 PHA02790
Kelch-like protein; Provisional
 417-634 1.46e-12

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 70.07  E-value: 1.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  417 LYVVGG-----SNGHSDDLSCGEmydsniDDWIPVPELRTNRCNAGVCALNGKLYIVGG-SDPYGQKGLKNCDVFdpvtk 490
Cdd:PHA02790 274 VYLIGGwmnneIHNNAIAVNYIS------NNWIPIPPMNSPRLYASGVPANNKLYVVGGlPNPTSVERWFHGDAA----- 342

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  491 lWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNclNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGgfdgs 570
Cdd:PHA02790 343 -WVNMPSLLKPRCNPAVASINNVIYVIGGHSETD--TTTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVG----- 414

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12003207  571 haiSCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWS 634
Cdd:PHA02790 415 ---RNAEFYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSWN 475
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 548-593 1.96e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 61.86  E-value: 1.96e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 12003207   548 ARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMT 593
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 501-546 2.08e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 61.86  E-value: 2.08e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 12003207   501 RRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMN 546
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-121 2.99e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 63.72  E-value: 2.99e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDpHGISHVKF-DDLNPEAVEVLLNYAYTAQLKADKE 100
Cdd:cd18332  10 LNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVG-EGVSVLTLpSGLEARGFQLLLDFMYTSRLPLTPR 88

                        90       100
                ....*....|....*....|.
gi 12003207 101 LVKDVYSAAKKLKMDRVKQVC 121
Cdd:cd18332  89 TVPAVLAAATYLQMEHVVETC 109
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-121 3.23e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 63.51  E-value: 3.23e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSdphgiSHVKFDDLNPEAVEVLLNYAYTAQLKADKE 100
Cdd:cd18205   8 KANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNS-----QHYTLDFLSPKTFQQILEYAYTATLQAKVE 82

                        90       100
                ....*....|....*....|.
gi 12003207 101 LVKDVYSAAKKLKMDRVKQVC 121
Cdd:cd18205  83 DLDDLLYAAEILEIEYLEEQC 103
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-121 4.41e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 63.33  E-value: 4.41e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHgiSHVKFDDLN---PEAVEVLLNYAYTAQLKA 97
Cdd:cd18202   9 QLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAVS--SHEAVVDLSgfcKSSFLPLLEFAYTSELTF 86

                        90       100
                ....*....|....*....|....
gi 12003207  98 DKELVKDVYSAAKKLKMDRVKQVC 121
Cdd:cd18202  87 DFCSMAEVAMLARHLFMNEVLEIC 110
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-138 4.57e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 63.53  E-value: 4.57e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  16 ESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQL 95
Cdd:cd18335   4 EQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCL 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 12003207  96 KADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYR 138
Cdd:cd18335  84 ELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGIR 126
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-125 6.47e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 63.03  E-value: 6.47e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  10 EDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFE---IFNSDSDphgishVKFDDLNPEAVEVL 86
Cdd:cd18227   4 EFPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDqvlLKNSRRI------VLPDVMNPRVFENI 77

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 12003207  87 LNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18227  78 LLSCYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELL 116
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-136 7.09e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 62.88  E-value: 7.09e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207   9 FEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLN 88
Cdd:cd18268   1 FKDQDLSSELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 12003207  89 YAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCIS 136
Cdd:cd18268  81 YVYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLS 128
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-114 8.89e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 62.33  E-value: 8.89e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNS-DSDPhgisHVKFDDLNPEAVEVLLNYAYTAQLKA-D 98
Cdd:cd18221   8 RLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDfTQEP----LVEIEGVSNMAFRHLIEFTYTAKLMVqG 83

                        90
                ....*....|....*.
gi 12003207  99 KELVKDVYSAAKKLKM 114
Cdd:cd18221  84 EEEANDVWKAAEYLQM 99
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-121 9.47e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 62.53  E-value: 9.47e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYlFEIFNSD-SDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKE 100
Cdd:cd18194  14 LREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMY-FHLFYRDrLDKRDLVRLNSDIVTAPAFGLLLDFMYEGRLALRDL 92

                        90       100
                ....*....|....*....|.
gi 12003207 101 LVKDVYSAAKKLKMDRVKQVC 121
Cdd:cd18194  93 PVEDVLAAASYLHMYDIVKVC 113
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-124 1.54e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 60.97  E-value: 1.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  31 FCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSD----SDPHGIShVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVY 106
Cdd:cd18307   1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNdmkaTDELSIT-IDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLL 79

                        90
                ....*....|....*...
gi 12003207 107 SAAKKLKMDRVKQVCGDY 124
Cdd:cd18307  80 KGAKYFNIPRLKDHCVDF 97
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-131 2.09e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 61.39  E-value: 2.09e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18279   9 LGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKM 88

                        90       100       110
                ....*....|....*....|....*....|
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYLLSRMDV 131
Cdd:cd18279  89 ADDLLAAADKYALERLKVMCEDALCSNLSV 118
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-138 2.15e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 61.62  E-value: 2.15e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207   9 FEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLN 88
Cdd:cd18337   1 FQALNHAEQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQ 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 12003207  89 YAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYR 138
Cdd:cd18337  81 YAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIR 130
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-121 3.41e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 60.71  E-value: 3.41e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPhgishVKFDDLNPEAVEVLLNYAYTAQLKADKE 100
Cdd:cd18206  12 QLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQKDV-----VHLDISNAAGLGQVLEFMYTAKLSLSPE 86

                        90       100
                ....*....|....*....|.
gi 12003207 101 LVKDVYSAAKKLKMDRVKQVC 121
Cdd:cd18206  87 NVDDVLAVATFLQMQDIVTAC 107
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 30-121 3.42e-11

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 60.05  E-value: 3.42e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  30 QFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAA 109
Cdd:cd18314   5 EFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLA 84

                        90
                ....*....|..
gi 12003207 110 KKLKMDRVKQVC 121
Cdd:cd18314  85 SKYQVPDLEKLC 96
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 132-220 3.69e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 60.32  E-value: 3.69e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 132 TSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKLYTKVINWVQRSIWENG 210
Cdd:cd18445   4 SNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVcELISSDDLTVPSEEKVFEAVMSWVNHDPENRK 83

                        90
                ....*....|
gi 12003207 211 DSLEELMEEV 220
Cdd:cd18445  84 EHLAELLEHV 93
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 357-402 4.56e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 58.01  E-value: 4.56e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 12003207   357 ARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMR 402
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-131 9.55e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 59.48  E-value: 9.55e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18345   9 LGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKAPNLDKM 88

                        90       100       110
                ....*....|....*....|....*....|
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYLLSRMDV 131
Cdd:cd18345  89 ADDLLAAADKYALERLKVMCEEALCSNLSV 118
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-130 9.76e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 59.98  E-value: 9.76e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  16 ESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQL 95
Cdd:cd18261  13 DAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYTGQI 92

                        90       100       110
                ....*....|....*....|....*....|....*
gi 12003207  96 KADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMD 130
Cdd:cd18261  93 LLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELN 127
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-134 1.09e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 59.87  E-value: 1.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  23 NALRKSGQFCDVRL---QVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDD------LNPEAVEVLLNYAYTA 93
Cdd:cd18241  15 NEQRKQGLFCDITLafgGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKwssepgPDPDTVEAVIQYMYTG 94

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 12003207  94 QLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSC 134
Cdd:cd18241  95 RIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-121 1.25e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 59.28  E-value: 1.25e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18325  14 LSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSDIVTAPAFSLLLEFMYEGKLEFSSLP 93

                        90       100
                ....*....|....*....|
gi 12003207 102 VKDVYSAAKKLKMDRVKQVC 121
Cdd:cd18325  94 VEDVLAAASYLHMYDIVKVC 113
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-135 1.28e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 59.22  E-value: 1.28e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGIS---HVKFDDLNPEAVEVLLNYAYTAQLKA 97
Cdd:cd18258   7 ELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGeklELTMSNINADVLELLLEFVYTGSLII 86

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 12003207  98 DKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCI 135
Cdd:cd18258  87 DSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCL 124
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-121 1.55e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 59.67  E-value: 1.55e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYlFEIFNSDS-DPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKE 100
Cdd:cd18324  14 LSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMY-FHLFYKDQlDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDL 92

                        90       100
                ....*....|....*....|.
gi 12003207 101 LVKDVYSAAKKLKMDRVKQVC 121
Cdd:cd18324  93 PIEDVLAAASYLHMYDIVKVC 113
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-128 1.80e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 58.91  E-value: 1.80e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  16 ESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDD--LNPEAVEVLLNYAYTA 93
Cdd:cd18196   6 EQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSevVTAEAFAALIDMMYTS 85

                        90       100       110
                ....*....|....*....|....*....|....*
gi 12003207  94 QLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSR 128
Cdd:cd18196  86 TLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTR 120
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-125 2.13e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 57.86  E-value: 2.13e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  32 CDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDphgishvkfDDLN---PEAVEV-----LLNYAYTAQLKADKELVK 103
Cdd:cd18955   2 CDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTD---------GDLVitlPEEVTVkgfepLLQFAYTAKLLLSKENVL 72

                        90       100
                ....*....|....*....|..
gi 12003207 104 DVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18955  73 EVCRCAEFLGVHNIEKACFDFL 94
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-125 2.64e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 58.15  E-value: 2.64e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  16 ESSVAKLNAL------RKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPhgishvkfdDLN---PEAVEV- 85
Cdd:cd18277   6 ESSVHSTNVLlslndqRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQADA---------ELNitlPEEVTVk 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 12003207  86 ----LLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18277  77 gfepLIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
585-635 3.16e-10

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 61.33  E-value: 3.16e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 12003207 585 EWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSP 635
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSE 52
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-121 3.60e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 57.74  E-value: 3.60e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPY---LFEIFNSDSDphgiSHVKFDDLNPEAVEVLLNYAYTAQLKAD 98
Cdd:cd18204   9 LNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYfkkLFKKLEVDSS----SVIEIDFLRSDIFEEVLNYMYTAKISVK 84

                        90       100
                ....*....|....*....|...
gi 12003207  99 KELVKDVYSAAKKLKMDRVKQVC 121
Cdd:cd18204  85 KEDVNLMMSSGQILGIRFLDKLC 107
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 134-220 4.55e-10

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 57.17  E-value: 4.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207   134 CISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLE-DNVCLPSNGKLYTKVINWVQRSIWENGDS 212
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSsDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80


                  ....*...
gi 12003207   213 LEELMEEV 220
Cdd:pfam07707  81 LPELLSAV 88
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 31-113 4.58e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 56.40  E-value: 4.58e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  31 FCDVRLqVC-GHEMLAHRAVLACCSPYLFEIFnSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAA 109
Cdd:cd18315   1 LVDVTL-ACeGGSLKAHKLVLAAASPYFAALL-KETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLA 78


                ....
gi 12003207 110 KKLK 113
Cdd:cd18315  79 ELLQ 82
Kelch smart00612
Kelch domain;
416-463 4.59e-10

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 55.26  E-value: 4.59e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 12003207    416 QLYVVGGSNGhSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNG 463
Cdd:smart00612   1 KIYVVGGFDG-GQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-131 5.20e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 57.42  E-value: 5.20e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKE 100
Cdd:cd18342  12 ELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDK 91

                        90       100       110
                ....*....|....*....|....*....|.
gi 12003207 101 LVKDVYSAAKKLKMDRVKQVCGDYLLSRMDV 131
Cdd:cd18342  92 MADDLLAAADKYALERLKVMCEDALCSNLSV 122
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-121 6.21e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 57.15  E-value: 6.21e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVkFDDLNPEAVEVLLNYAYTAQLKADKE 100
Cdd:cd18224  16 ELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTELDVARTYV-VDFITPANFEKVLSFIYTSELFTDLI 94

                        90       100
                ....*....|....*....|.
gi 12003207 101 LVKDVYSAAKKLKMDRVKQVC 121
Cdd:cd18224  95 NVGVIYEVAEKLGMEDLLKAC 115
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 453-499 6.46e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 54.93  E-value: 6.46e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 12003207   453 RCNAGVCALNGKLYIVGGSDpyGQKGLKNCDVFDPVTKLWTSCAPLN 499
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFD--GNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-131 7.37e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 56.94  E-value: 7.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18343  12 LGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKM 91

                        90       100       110
                ....*....|....*....|....*....|
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYLLSRMDV 131
Cdd:cd18343  92 ADNLLAAADKYALERLKVMCEEALCNNLSV 121
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-125 9.04e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 56.57  E-value: 9.04e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207   7 LMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYlFEIFNSDSDPHG--ISHVKfddlNPEAVE 84
Cdd:cd18220   1 IQFDVPEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPY-FRDHSALSTMSGlsISVIK----NPNVFE 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 12003207  85 VLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18220  76 QLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL 116
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 132-220 9.91e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 56.16  E-value: 9.91e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 132 TSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLK-LEVMLEDNVCLPSNGKLYTKVINWVQRSIWENG 210
Cdd:cd18457   4 NNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEvLEILSRDELNVKSEEQVFEAALAWVKYDRENRE 83

                        90
                ....*....|
gi 12003207 211 DSLEELMEEV 220
Cdd:cd18457  84 EYLPELLSKV 93
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-125 1.15e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 56.59  E-value: 1.15e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207   7 LMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFN-SDSDPHGISHVKfddlNPEAVEV 85
Cdd:cd18222   1 IQLEIPDFSNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSlNEMSTVSISVIK----NPTVFEQ 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 12003207  86 LLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18222  77 LLSFCYTGRICLQLADIISYLTAASFLQMQHIIDKCTQIL 116
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-125 1.19e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 56.40  E-value: 1.19e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFnSDSDPHGISHVKFD-DLNPEAVEVLLNYAYTAQLKADKE 100
Cdd:cd18331  15 LNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIF-TDQLKCNLSVINLDpEINPEGFNILLDFMYTSRLNLREG 93

                        90       100
                ....*....|....*....|....*
gi 12003207 101 LVKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18331  94 NIMAVMATAMYLQMEHVVDTCRKFI 118
Kelch smart00612
Kelch domain;
608-635 1.36e-09

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 53.72  E-value: 1.36e-09
                           10        20
                   ....*....|....*....|....*...
gi 12003207    608 IYAVGGFDGNEFLNTVEVYNLESNEWSP 635
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTP 29
PHA02790 PHA02790
Kelch-like protein; Provisional
 374-588 1.69e-09

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 60.44  E-value: 1.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  374 GGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSnghsDDLSCGEMYDSNIDDWIPVPELRTNR 453
Cdd:PHA02790 278 GGWMNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGL----PNPTSVERWFHGDAAWVNMPSLLKPR 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  454 CNAGVCALNGKLYIVGG---SDPYGQKGLKNCDV--FDPVTKL--WTSCAPLNIRRhqsavcelggyLYIIGgaeswncl 526
Cdd:PHA02790 354 CNPAVASINNVIYVIGGhseTDTTTEYLLPNHDQwqFGPSTYYphYKSCALVFGRR-----------LFLVG-------- 414

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12003207  527 NTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKM 588
Cdd:PHA02790 415 RNAEFYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSWNI 476
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-123 1.74e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 56.02  E-value: 1.74e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGH----EMLAHRAVLACCSPYLFEIF-NSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLK 96
Cdd:cd18211  16 MHKLRLLGHLCDVTVQVEHQgskeEFSAHKAVLAASSKYFKEVFlNEKISDGKNTNVMLNEIYTADFASFLEFVYTAKVE 95

                        90       100
                ....*....|....*....|....*..
gi 12003207  97 ADKELVKDVYSAAKKLKMDRVKQVCGD 123
Cdd:cd18211  96 VEEDRVQRMLEIAEKLKCLDLSETCFQ 122
PLN02193 PLN02193
nitrile-specifier protein
 457-613 1.76e-09

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 60.35  E-value: 1.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  457 GVC--ALNGKLYIVGGSDPYGQ-KGLKNcdvFDPVTKLWTSCAPL----NIRRHQSAVCELGGyLYIIGGAESWNCLNTV 529
Cdd:PLN02193 221 GVRmvSIGSTLYVFGGRDASRQyNGFYS---FDTTTNEWKLLTPVeegpTPRSFHSMAADEEN-VYVFGGVSATARLKTL 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  530 ERYNPENNTWTLIA-PMN--VARRGAGVAVLNGKLFVCGGFDGSHaISCVEMYDPTRNEW---KMMGNMTSPRSNAGIAT 603
Cdd:PLN02193 297 DSYNIVDKKWFHCStPGDsfSIRGGAGLEVVQGKVWVVYGFNGCE-VDDVHYYDPVQDKWtqvETFGVRPSERSVFASAA 375

                        170
                 ....*....|
gi 12003207  604 VGNTIYAVGG 613
Cdd:PLN02193 376 VGKHIVIFGG 385
PLN02193 PLN02193
nitrile-specifier protein
 453-634 2.27e-09

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 59.97  E-value: 2.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  453 RCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWT-----------SCapLNIRrhqsaVCELGGYLYIIGGAE 521
Cdd:PLN02193 166 RCSHGIAQVGNKIYSFGGEFTPNQPIDKHLYVFDLETRTWSispatgdvphlSC--LGVR-----MVSIGSTLYVFGGRD 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  522 SWNCLNTVERYNPENNTWTLIAPMN---VARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEW---KMMGNMTSP 595
Cdd:PLN02193 239 ASRQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWfhcSTPGDSFSI 318

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 12003207  596 RSNAGIATVGNTIYAVGGFDGNEfLNTVEVYNLESNEWS 634
Cdd:PLN02193 319 RGGAGLEVVQGKVWVVYGFNGCE-VDDVHYYDPVQDKWT 356
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-95 2.42e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 55.43  E-value: 2.42e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207   7 LMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSD-----PHGIshvkfddlNPE 81
Cdd:cd18290   3 LQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSavvelPAAV--------QPQ 74

                        90
                ....*....|....
gi 12003207  82 AVEVLLNYAYTAQL 95
Cdd:cd18290  75 SFQQILSFCYTGRL 88
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-136 2.63e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 55.41  E-value: 2.63e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  14 FIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLfeIFNSDSDphgISHVKFDDLNPEAVEVLLNYAYT- 92
Cdd:cd18303   1 FISRLLKTVASLFDKELYSDITIKLADKSIPAHKFVLAARSEKW--SNENLAS---TNELDLSDISYEVVLALLRWLYTd 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 12003207  93 -AQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCIS 136
Cdd:cd18303  76 eLDLTLDDEFLLELMKAAKRFQLTDLVERCERALMSSVNVDNCIR 120
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-125 3.41e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 55.20  E-value: 3.41e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  19 VAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYlFEIFNSDSDPHGISHVKF--DDLNPEAVEVLLNYAYTAQLK 96
Cdd:cd18956  11 LGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVY-FHLFYRDRPAGGRDTVRLngDIVTAPAFGRLLDFMYEGRLD 89

                        90       100
                ....*....|....*....|....*....
gi 12003207  97 ADKELVKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18956  90 LRSLPVEDVLAAASYLHMYDIVKVCKGRL 118
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-125 3.52e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 55.22  E-value: 3.52e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207   7 LMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFN-SDSDPHGISHVKfddlNPEAVEV 85
Cdd:cd18214   1 LHFRFENYGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFLlNDSREVQISILQ----NSEVGRQ 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 12003207  86 LLNYAYTAQLK-ADKELVkDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18214  77 LLLSCYTGVLEfPEMELV-NYLTAASFLQMSHIVERCTQAL 116
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-121 3.53e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 54.83  E-value: 3.53e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPY----LFEIFNSDSDPhgiSHVKFDDLNPEAVEVLLNYAYTAQLK 96
Cdd:cd18329  11 QLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYfkmlLSQNAKETGQP---TVATFDVFSPDTFTIILDFVYSGKLS 87

                        90       100
                ....*....|....*....|....*
gi 12003207  97 ADKELVKDVYSAAKKLKMDRVKQVC 121
Cdd:cd18329  88 LTSQNVIEVMSAASYLQMTDVISVC 112
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-131 4.69e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 55.05  E-value: 4.69e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  11 DENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNsdsdphgISHVKFDDLNPEAVEVLLNYA 90
Cdd:cd18243  12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS-------INNLVLQGCSSIGLRLVLEYL 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 12003207  91 YTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDV 131
Cdd:cd18243  85 YTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISV 125
PHA02713 PHA02713
hypothetical protein; Provisional
 329-482 4.97e-09

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 59.25  E-value: 4.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  329 STPKLSKSLSFEMQQDELIEKPmsPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARF 408
Cdd:PHA02713 315 NNPSLNKVYKINIENKIHVELP--PMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSY 392

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  409 QMAVLMGQLYVVGGSNGHSDDLSCGEM-----------------YDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVggS 471
Cdd:PHA02713 393 GMCVLDQYIYIIGGRTEHIDYTSVHHMnsidmeedthssnkvirYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVV--C 470

                        170
                 ....*....|.
gi 12003207  472 DPYGQKGLKNC 482
Cdd:PHA02713 471 DIKDEKNVKTC 481
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-99 7.43e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 53.72  E-value: 7.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  17 SSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIF-NSDSDPHGISHVKFDDlnPEAVEVLLNYAYTAQL 95
Cdd:cd18209   4 SLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFtEKENESQSVFQLDFCE--PDAFENVLNYIYSSSL 81


                ....
gi 12003207  96 KADK 99
Cdd:cd18209  82 FVEK 85
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 129-221 8.45e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 54.33  E-value: 8.45e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 129 MDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLE-DNVCLPSNGKLYTKVINWVQRSIW 207
Cdd:cd18452   1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKsDEIQVDSEEPVFEAVLNWVKHDKE 80

                        90
                ....*....|....
gi 12003207 208 ENGDSLEELMEEVQ 221
Cdd:cd18452  81 EREDYLPELLQYVR 94
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-121 8.68e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 53.60  E-value: 8.68e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPhgISHVKFDDLNPEAVEVLLNYAYTAQLKADKE 100
Cdd:cd18217   8 RLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDN--IVFLDQSQVSADGFQKLLEFIYTGNLNLDSW 85

                        90       100
                ....*....|....*....|.
gi 12003207 101 LVKDVYSAAKKLKMDRVKQVC 121
Cdd:cd18217  86 NVAEIHQAASYLGMEEVVAKC 106
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-117 9.69e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 54.27  E-value: 9.69e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207   7 LMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNsdsdphGISHVKFD---DLNPEAV 83
Cdd:cd18289   5 LHIEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFS------GNSKSAFElpaTVPPACF 78

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 12003207  84 EVLLNYAYTAQLK--ADKELVkdVYSAAKKLKMDRV 117
Cdd:cd18289  79 QQILSFCYTGKLTmaASEQLV--VMYTAGFLQIQHI 112
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-125 1.08e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 53.31  E-value: 1.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  13 NFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYlfeiFNSDSDPHGISHVKFDD-LNPEAVEVLLNYAY 91
Cdd:cd18210   3 EITSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPY----FHDQVLLKNMSSISLPGvMDPGAFESVLASAY 78

                        90       100       110
                ....*....|....*....|....*....|....
gi 12003207  92 TAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18210  79 TGKLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-125 1.13e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 53.32  E-value: 1.13e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFE-IFNSDSDPHGISHVkfddLNPEAVEVLLNYAYTAQLKADKE 100
Cdd:cd18200   9 LNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDkLLLNDTNCLVLPSV----IEAAAFENLLQLIYSGRLTLCMD 84

                        90       100
                ....*....|....*....|....*
gi 12003207 101 LVKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18200  85 ALPSHLLVASGLQMWQVVDRCSELL 109
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 25-119 1.16e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 53.41  E-value: 1.16e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  25 LRK---SGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNS---DSDPHGISHVKfddLNPEAVEVLLNYAYTAQLKAD 98
Cdd:cd18295  10 LRRlleQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETkwkDKREINLKHPL---VNPDAFRALLQYLYTGRLEIH 86

                        90       100
                ....*....|....*....|.
gi 12003207  99 KELVKDVYSAAKKLKMDRVKQ 119
Cdd:cd18295  87 VDDVEDCKRLAKQCRLEELIE 107
PHA02790 PHA02790
Kelch-like protein; Provisional
 497-633 1.22e-08

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 57.75  E-value: 1.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  497 PLNIRR-----HQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSh 571
Cdd:PHA02790 252 PMNMDQiidifHMCTSTHVGEVVYLIGGWMNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNP- 330

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12003207  572 aiSCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFdgNEFLNTVEVYNLESNEW 633
Cdd:PHA02790 331 --TSVERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIGGH--SETDTTTEYLLPNHDQW 388
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-131 1.27e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 53.81  E-value: 1.27e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKA--DK 99
Cdd:cd18344  14 LGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTGKAPHlhSH 93

                        90       100       110
                ....*....|....*....|....*....|..
gi 12003207 100 ELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDV 131
Cdd:cd18344  94 SMACDVLAAADKYGLEGLKVLCEDALCRNLSV 125
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-132 1.33e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 53.53  E-value: 1.33e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIF---NSDSDPHGISHVkfDDLNPEAVEVLLNYAYTAQLKA 97
Cdd:cd18230  11 ELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYcqvQKTSDQATVTHL--DIVTAQGFKAIIDFMYSAHLAL 88

                        90       100       110
                ....*....|....*....|....*....|....*
gi 12003207  98 DKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVT 132
Cdd:cd18230  89 TSKNVIEVMSAASYLQMTDIVQACHNFIKAALDIS 123
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-112 1.52e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 52.87  E-value: 1.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  15 IESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSdsdpHGI---SHV-KFDDLNPEAVEVLLNYA 90
Cdd:cd18223   2 SDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSS----QEIwisSHVlELPDLKAEVFAEILNFI 77

                        90       100
                ....*....|....*....|...
gi 12003207  91 YTAQLKA-DKELVKDVYSAAKKL 112
Cdd:cd18223  78 YSSKVVVkRQETVTDLVAAGKKL 100
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 129-228 1.68e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 52.70  E-value: 1.68e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 129 MDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLP-RLKLEVMLEDNVCLPSNGKLYTKVINWVQRSIW 207
Cdd:cd18456   1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPlKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                        90       100
                ....*....|....*....|.
gi 12003207 208 ENGDSLEELMEEVQTLYYSAD 228
Cdd:cd18456  81 GRRQHVPRLMKCVRLPLLSRD 101
PHA03098 PHA03098
kelch-like protein; Provisional
 509-641 1.74e-08

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 57.47  E-value: 1.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  509 ELGGYLYIIGGaeSWNCLNTVERYNPENNTWTLIAPMNVaRRGAGVAVLNGKLFVCGGFDGS-HAISCVEMYDPTRNEWK 587
Cdd:PHA03098 248 TFGSIIYIHIT--MSIFTYNYITNYSPLSEINTIIDIHY-VYCFGSVVLNNVIYFIGGMNKNnLSVNSVVSYDTKTKSWN 324

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 12003207  588 MMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTKIFQ 641
Cdd:PHA03098 325 KVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIF 378
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 34-112 1.85e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 51.51  E-value: 1.85e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12003207  34 VRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKL 112
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-125 1.86e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 52.81  E-value: 1.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPY----LFEIFNSDSDPhgiSHVKFDDLNPEAVEVLLNYAYTAQLK 96
Cdd:cd18199   8 QLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYfrmlLSHYIQDTGRP---STASFDVFSSDAFSIILDFVYSGKLS 84

                        90       100
                ....*....|....*....|....*....
gi 12003207  97 ADKELVKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18199  85 LTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-125 3.13e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 52.18  E-value: 3.13e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207   7 LMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDphgiSHVKFDDL-NPEAVEV 85
Cdd:cd18197   1 LHFKFEQQGDAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFLLNQS----KQVRITILqSAEVGRK 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 12003207  86 LLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18197  77 LLLSCYTGALEVKKKELLKYLTAASYLQMVHIVEKCTEAL 116
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-125 3.27e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 52.24  E-value: 3.27e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIF-----NSDSdphgiSHVKFDDLNPEAVEVLLNYAYTAQL- 95
Cdd:cd18287  13 IGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLyggmrESQQ-----SEIELKDTNAEAFKALLKYIYTGRLt 87

                        90       100       110
                ....*....|....*....|....*....|..
gi 12003207  96 --KADKELVKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18287  88 ltDLKEDVLLDVLGLAHQYGFEELEAAISDYL 119
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 132-221 4.28e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 52.34  E-value: 4.28e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 132 TSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKLYTKVINWVQRSIWENG 210
Cdd:cd18512   4 TNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVcSLIASDKLTISSEEKVFEAVIAWVNHDKEVRQ 83

                        90
                ....*....|.
gi 12003207 211 DSLEELMEEVQ 221
Cdd:cd18512  84 EHMAHLMEHVR 94
Kelch_6 pfam13964
Kelch motif;
502-549 4.43e-08

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 49.64  E-value: 4.43e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 12003207   502 RHQSAVCELGGYLYIIGGAE-SWNCLNTVERYNPENNTWTLIAPMNVAR 549
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTnASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch smart00612
Kelch domain;
464-512 4.53e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 49.48  E-value: 4.53e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 12003207    464 KLYIVGGSDpyGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGG 512
Cdd:smart00612   1 KIYVVGGFD--GGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-130 4.79e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 51.74  E-value: 4.79e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPY--------LFEIFNSDSDPHGISHvkfddlnpEAVEVLLNYAYTA 93
Cdd:cd18251  14 LVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYfrgmfaggLREMQQTEVLIHGVSY--------NAMCKILDFIYTS 85

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 12003207  94 QLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMD 130
Cdd:cd18251  86 ELELSLDNVQETLTAACQLQIPEVIGFCCDFLMSWVD 122
PRK14131 PRK14131
N-acetylneuraminate epimerase;
510-616 6.10e-08

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 55.02  E-value: 6.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  510 LGGYLYI-IGGAE-SWNCLNTveryNPENNTWTLIAPM-NVARRGAGVAVLNGKLFVCGGF-----DGS-HAISCVEMYD 580
Cdd:PRK14131  37 DNNTVYVgLGSAGtSWYKLDL----NAPSKGWTKIAAFpGGPREQAVAAFIDGKLYVFGGIgktnsEGSpQVFDDVYKYD 112

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 12003207  581 PTRNEWKMMgNMTSPRSNAGIATV---GNTIYAVGG-----FDG 616
Cdd:PRK14131 113 PKTNSWQKL-DTRSPVGLAGHVAVslhNGKAYITGGvnkniFDG 155
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-125 6.57e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 51.09  E-value: 6.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  30 QFCDVRLQV--CGHEMLAHRAVLACCSPYLFEIF------NSDSDPHGIShvkfdDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18294  13 EFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFltgpqkESTQSPLVLS-----DIEPEVFRAVLEFIYTNCVTLSNHT 87

                        90       100
                ....*....|....*....|....
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18294  88 VIEVLAAAVEYGLDELRKLCERFI 111
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-121 6.89e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 51.22  E-value: 6.89e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  13 NFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLfeifnSDSDPHGISHVKFDD-LNPEAVEVLLNYAY 91
Cdd:cd18208   7 NFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFF-----QDKLLLGYSDIEIPSvVSVQSVQKLIDFMY 81

                        90       100       110
                ....*....|....*....|....*....|
gi 12003207  92 TAQLKADKELVKDVYSAAKKLKMDRVKQVC 121
Cdd:cd18208  82 SGVLRVSQSEALQILTAASILQIKTVIDEC 111
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-125 7.84e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 51.08  E-value: 7.84e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  19 VAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPY---LFEIFNSDSDPHgiSHVKFDDLNPEAVEVLLNYAYTAQL 95
Cdd:cd18330   6 LGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYfraLLIHYIQDSGRH--STASLDIVTSEAFSIILDFLYSGKL 83

                        90       100       110
                ....*....|....*....|....*....|
gi 12003207  96 KADKELVKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18330  84 DLCSENVIEVMSAASYLQMTDVVNFCKGYI 113
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 132-220 8.85e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 50.38  E-value: 8.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 132 TSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLED-NVCLPSNGKLYTKVINWVQRSIWENG 210
Cdd:cd18448   5 SNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSsDLNVESESQVYEAVMKWVKHDPQHRK 84

                        90
                ....*....|
gi 12003207 211 DSLEELMEEV 220
Cdd:cd18448  85 RHLDDLLSQV 94
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 129-203 1.10e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 49.91  E-value: 1.10e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12003207 129 MDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDNVcLPSNGK--LYTKVINWVQ 203
Cdd:cd18465   1 MSVETCLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNK-LKNCSEidLFRAAIRWLQ 76
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-135 1.44e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 50.62  E-value: 1.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207   9 FEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLN 88
Cdd:cd18236   2 FDDTGLSLVLQNGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLD 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 12003207  89 YAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCI 135
Cdd:cd18236  82 YTYTSKVLITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENCV 128
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-121 1.47e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 49.94  E-value: 1.47e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  25 LRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGIShvkFDDLNPEAVEVLLNYAYTAQLKADKELVKD 104
Cdd:cd18218  12 LRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTNPNPGQWCL---GEGISPSTFKQLLDFVYGESVEVQPGELRP 88

                        90
                ....*....|....*..
gi 12003207 105 VYSAAKKLKMDRVKQVC 121
Cdd:cd18218  89 LLEAARALEVESLEEAC 105
PRK14131 PRK14131
N-acetylneuraminate epimerase;
502-629 1.57e-07

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 53.87  E-value: 1.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  502 RHQSAVCELGGYLYIIGGAESWN------CLNTVERYNPENNTWT---LIAPMNVArRGAGVAVLNGKLFVCGG-----F 567
Cdd:PRK14131  75 REQAVAAFIDGKLYVFGGIGKTNsegspqVFDDVYKYDPKTNSWQkldTRSPVGLA-GHVAVSLHNGKAYITGGvnkniF 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  568 DG---------------------------------SHAIScvemYDPTRNEWKMMGnmTSPRS-NAGIATV--GNTIYAV 611
Cdd:PRK14131 154 DGyfedlaaagkdktpkdkindayfdkkpedyffnKEVLS----YDPSTNQWKNAG--ESPFLgTAGSAVVikGNKLWLI 227

                        170       180
                 ....*....|....*....|.
gi 12003207  612 GGfdgnEF---LNTVEVYNLE 629
Cdd:PRK14131 228 NG----EIkpgLRTDAVKQGK 244
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 31-130 2.13e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 49.99  E-value: 2.13e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  31 FCDVRLQVCGHEMLAHRAVLACCSPYLFEIFN-----SDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDV 105
Cdd:cd18296  17 FPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRdhfaeSEENNGSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDV 96

                        90       100
                ....*....|....*....|....*
gi 12003207 106 YSAAKKLKMDRVKQVCGDYLLSRMD 130
Cdd:cd18296  97 LYVADMYLLPGLKRLCGTVLAQSLD 121
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-124 2.47e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 49.79  E-value: 2.47e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  19 VAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPhGISHVKFDDLNPEAVEVLLNYAYTAQLKAD 98
Cdd:cd18212  11 LTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGEV-GQSIYMLEGMVAETFGALLEFIYTGCLQVG 89

                        90       100
                ....*....|....*....|....*.
gi 12003207  99 KELVKDVYSAAKKLKMDRVKQVCGDY 124
Cdd:cd18212  90 EKSLEQILATAQFLKVNDLVKAYSDY 115
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-121 2.92e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 49.63  E-value: 2.92e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQL------ 95
Cdd:cd18280   5 FGALLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDELpddvep 84

                        90       100       110
                ....*....|....*....|....*....|..
gi 12003207  96 ------KADKELVKDVYSAAKKLKMDRVKQVC 121
Cdd:cd18280  85 agsdssSLDTTMAQHLLAAADRYALERLRLLC 116
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 129-203 3.32e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 48.44  E-value: 3.32e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12003207 129 MDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKLYTKVINWVQ 203
Cdd:cd18458   2 LDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLvALISRDELNVRCESEVYNAVIRWVK 77
Kelch_3 pfam13415
Galactose oxidase, central domain;
511-557 3.90e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 46.90  E-value: 3.90e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 12003207   511 GGYLYIIGGA--ESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVL 557
Cdd:pfam13415   1 GDKLYIFGGLgfDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 130-184 4.34e-07

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 46.89  E-value: 4.34e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12003207 130 DVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLED 184
Cdd:cd14733   1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 132-206 4.45e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 48.76  E-value: 4.45e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12003207 132 TSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVML-EDNVCLPSNGKLYTKVINWVQRSI 206
Cdd:cd18510   5 SNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLaSDDINVPDEETIFQALMMWVRHDL 80
BTB1_POZ_LZTR1 cd18308
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 25-125 7.11e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349617 [Multi-domain]  Cd Length: 156  Bit Score: 49.30  E-value: 7.11e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  25 LRKSGQFCDVRLqVCGHE---MLAHRAVLACCSPYL------------------FEIFNSDSDPHGIS-------HVKFD 76
Cdd:cd18308  17 LLESRQFCDVEF-IVGEEeerIPAHIAFVAARSKWLrnkilqarerqkqkaeqeVEDEGSEADSSSASkndspmlEVRLP 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  77 DLNPEAVEVLLNYAYTAQLK-----------ADKELVKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18308  96 EADPEAFELILSFIYTDKIDptrkgqdpgsnEVVLLMMDVYRLALQFQMSRLEQLCVQYL 155
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-123 7.80e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 48.35  E-value: 7.80e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDS---DPHGISHVKFDDLNPEAVEV----------LL 87
Cdd:cd18195   8 QLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLplgAAAVAAAPGATQSPERVLELpgvkagvfsdVL 87

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 12003207  88 NYAYTAQLKAD-KELVKDVYSAAKKLKMDRVKQVCGD 123
Cdd:cd18195  88 NFIYSSRVALPgSAAAKELGAAGKRLGIPFLQGLEGG 124
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-125 8.10e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 48.41  E-value: 8.10e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPY---LFEIFNSDS-DPHGISHVkfDDLNPEAVEVLLNYAYTAQLK 96
Cdd:cd18201  11 ELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFfktLYCFTNKEScDQTTVTHL--DVVAVQGFSVILDFMYSGNLV 88

                        90       100
                ....*....|....*....|....*....
gi 12003207  97 ADKELVKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18201  89 LTSQNAIEVMSVASYLQMTEVVQSCRNFI 117
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 128-221 9.62e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 47.42  E-value: 9.62e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 128 RMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKLYTKVINWVQRSI 206
Cdd:cd18459   1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLiDIISSDELNVRSEEQVFNAVMAWVKYNI 80

                        90
                ....*....|....*
gi 12003207 207 WENGDSLEELMEEVQ 221
Cdd:cd18459  81 QERRPHLPQVLQHVR 95
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-128 1.10e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 47.61  E-value: 1.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  45 AHRAVLACCSPYLFEIFNSDSDPHGIShVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDY 124
Cdd:cd18231  30 AHKGVLAAYSQFFHSLFTQNKQLQRVE-LSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLNAAAVLQMNDIAASCQEL 108


                ....
gi 12003207 125 LLSR 128
Cdd:cd18231 109 IDSR 112
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 132-217 1.33e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 47.32  E-value: 1.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 132 TSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLK-LEVMLEDNVCLPSNGKLYTKVINWVQRSIWENG 210
Cdd:cd18509   5 SNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEElHKLLASDDVNVPDEETIFHALMMWVKYDMQRRC 84


                ....*..
gi 12003207 211 DSLEELM 217
Cdd:cd18509  85 SDLSMLL 91
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 21-114 1.48e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 47.19  E-value: 1.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSGQFCDVRLQ-VCGHEMLAHRAVLACCSPYlfeiFNS--------DSDPHGISHVKFDdlnpeAVEVLLNYAY 91
Cdd:cd18311   4 RLQNLFNKTEYCDLTLQfRDNEQLKVHRLVLSACTDY----FNVleqtceivDDTLIMPNELQAD-----AVVPVINFMY 74

                        90       100
                ....*....|....*....|...
gi 12003207  92 TAQLKADKELVKDVYSAAKKLKM 114
Cdd:cd18311  75 TGQLEFEEKSYGKLLRTAKELNM 97
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 33-92 1.70e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 46.90  E-value: 1.70e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12003207  33 DVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDS----DPHGISHVKFDDLNPEAVEVLLNYAYT 92
Cdd:cd18301  20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLltseDAVGCDVVHIEKVPPEIFEQLLQFIYT 83
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-121 2.13e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 46.78  E-value: 2.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  14 FIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPylfeiFNSDSDPHGISHVKFDDLNP-EAVEVLLNYAYT 92
Cdd:cd18229   1 FSKSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSP-----FFHDKLLLGHSEIEVPPVVPaQTVRQLVEFMYS 75

                        90       100
                ....*....|....*....|....*....
gi 12003207  93 AQLKADKELVKDVYSAAKKLKMDRVKQVC 121
Cdd:cd18229  76 GSLVVAQSEALQILTAASILQIKTVIDEC 104
PHA02713 PHA02713
hypothetical protein; Provisional
 494-613 2.16e-06

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 50.78  E-value: 2.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  494 SCAPLNIRRHQSAVCElggYLYIIGGAESWN--CLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSH 571
Cdd:PHA02713 288 STIPNHIINYASAIVD---NEIIIAGGYNFNnpSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTN 364

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 12003207  572 AISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGG 613
Cdd:PHA02713 365 VERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGG 406
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 132-221 2.57e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 46.60  E-value: 2.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 132 TSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVML-EDNVCLPSNGKLYTKVINWVQRSIWENG 210
Cdd:cd18511   5 SNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLaSDDMNIPNEETILNALLSWVRHDVEQRR 84

                        90
                ....*....|.
gi 12003207 211 DSLEELMEEVQ 221
Cdd:cd18511  85 KDLSKLLAYIR 95
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 129-206 2.58e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 45.78  E-value: 2.58e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12003207 129 MDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLE-DNVCLPSNGKLYTKVINWVQRSI 206
Cdd:cd18480   1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEaDELNVPDEEAVLKAVLRWTKHDL 79
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-125 3.82e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 46.81  E-value: 3.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL 101
Cdd:cd18266  16 LNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVIDFLYSSELPLDGGN 95

                        90       100
                ....*....|....*....|....
gi 12003207 102 VKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18266  96 IDYVLETAHLLQIWKVVDFCCEYL 119
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 132-229 4.46e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 46.60  E-value: 4.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 132 TSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKLYTKVINWVQRSIWENG 210
Cdd:cd18513   4 TNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVcSLISSDKLTVSSEEKVFEAVISWIKYDKEARL 83

                        90
                ....*....|....*....
gi 12003207 211 DSLEELMEEVQTLYYSADH 229
Cdd:cd18513  84 EHMAKLMEHVRLPLLPRDY 102
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 32-135 5.32e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 45.96  E-value: 5.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  32 CDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKK 111
Cdd:cd18263  14 CDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWENLFEATCTALQ 93

                        90       100
                ....*....|....*....|....
gi 12003207 112 LKMDRVKQVCGDYLLSRMDVTSCI 135
Cdd:cd18263  94 LQISGALALCLDFLQREISPARCL 117
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-134 6.84e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 45.17  E-value: 6.84e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  33 DVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSdphgishVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKL 112
Cdd:cd18275   6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDI-------LKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFL 78

                        90       100
                ....*....|....*....|..
gi 12003207 113 KMDRVKQVCGDYLLSRMDVTSC 134
Cdd:cd18275  79 QMPCAAQCAVDAVRAQLCLGNC 100
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-121 1.20e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 44.87  E-value: 1.20e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIF--NSDSDPH-GISHvkfddlNPEAVEVLLNYAYTAQLK-A 97
Cdd:cd18203  16 MNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFllNPSSELQvSLMH------SSRVVADLLLSCYTGALEfS 89

                        90       100
                ....*....|....*....|....
gi 12003207  98 DKELVkDVYSAAKKLKMDRVKQVC 121
Cdd:cd18203  90 VRDIV-NYLTAASYLQMEHVVEKC 112
Kelch_3 pfam13415
Galactose oxidase, central domain;
462-508 1.25e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 42.66  E-value: 1.25e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 12003207   462 NGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVC 508
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSAT 47
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 130-203 1.37e-05

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 43.55  E-value: 1.37e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12003207 130 DVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKLYTKVINWVQ 203
Cdd:cd18508   1 DATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLtELISSDRLNVPSEERVYEAAVAWLK 75
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-135 1.41e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 45.27  E-value: 1.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  29 GQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSA 108
Cdd:cd18272  30 GLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEELQETYEV 109

                        90       100
                ....*....|....*....|....*..
gi 12003207 109 AKKLKMDRVKQVCGDYLLSRMDVTSCI 135
Cdd:cd18272 110 ADMYQLTALFEECSRFLARTVQVRNCL 136
Kelch_6 pfam13964
Kelch motif;
453-502 1.69e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 42.32  E-value: 1.69e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 12003207   453 RCNAGVCALNGKLYIVGGSDPYGqKGLKNCDVFDPVTKLWTSCAPLNIRR 502
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNAS-PALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 404-450 1.78e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.21  E-value: 1.78e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 12003207   404 PRARFQMAVLMGQLYVVGGSNGHSdDLSCGEMYDSNIDDWIPVPELR 450
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQ-SLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-127 1.81e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 44.43  E-value: 1.81e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  10 EDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSpYLFEIFNSDSDPHGISHVKfddLNPEAVEVLLNY 89
Cdd:cd18225   2 ELPNYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASS-LLFKSLLDSTDTISIDASV---VSPEEFALLLEM 77

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 12003207  90 AYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLS 127
Cdd:cd18225  78 VYTGKLPPGKHNFTKIISVADSLQMFDVAVSCKNLLTS 115
PHA02713 PHA02713
hypothetical protein; Provisional
 432-611 2.88e-05

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 47.31  E-value: 2.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  432 CGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDpYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELG 511
Cdd:PHA02713 273 CILVYNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYN-FNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVID 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  512 GYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGG------FDGSHAISCVEM------- 578
Cdd:PHA02713 352 DTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGrtehidYTSVHHMNSIDMeedthss 431

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 12003207  579 -----YDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAV 611
Cdd:PHA02713 432 nkvirYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVV 469
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 22-125 5.20e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 42.58  E-value: 5.20e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFCDVRLQV-CGHEMLAHRAVLACCSPYLFEIFNSdsdphgisHVKF---DDLNPEAVEVLLNYAYTAQLKA 97
Cdd:cd18299   3 LRNLLHSPSCADVVFILqGGVRIFAHRIVLAAASSVFADLFLM--------MTVVtldSDITPEAFRRVLEFLYTGVLDE 74

                        90       100
                ....*....|....*....|....*...
gi 12003207  98 DKELVKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18299  75 NEDDLKELKDAAELLELFDLVMMCTNVL 102
PLN02153 PLN02153
epithiospecifier protein
 453-633 5.53e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 45.75  E-value: 5.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  453 RCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWtSCAPLNirrhqsavcelggylyiiGGAESWNCLntvery 532
Cdd:PLN02153  23 RCSHGIAVVGDKLYSFGGELKPNEHIDKDLYVFDFNTHTW-SIAPAN------------------GDVPRISCL------ 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  533 npenntwtliapmnvarrGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMT-----SPRSNAGIATVGNT 607
Cdd:PLN02153  78 ------------------GVRMVAVGTKLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKLDeeggpEARTFHSMASDENH 139

                        170       180       190
                 ....*....|....*....|....*....|..
gi 12003207  608 IYAVGGFDGNEFLN------TVEVYNLESNEW 633
Cdd:PLN02153 140 VYVFGGVSKGGLMKtperfrTIEAYNIADGKW 171
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-125 6.66e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 42.57  E-value: 6.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIF-NSDSDPHGISHVKFDDLNpeAVEVLLNYAYTAQLKADK 99
Cdd:cd18233   8 QLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFqNSSSQKNDVFHLDIKNVG--GIGQILDFMYTSHLDLNQ 85

                        90       100
                ....*....|....*....|....*.
gi 12003207 100 ELVKDVYSAAKKLKMDRVKQVCGDYL 125
Cdd:cd18233  86 DNVQVMLDIAQCLQVQNVLNMCYTFL 111
PLN02193 PLN02193
nitrile-specifier protein
 388-519 8.06e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 45.72  E-value: 8.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  388 YNPHTDHWSFLAPMR---TPRARFQMAVLMGQLYVVGGSnGHSDDLSCGEMYdsNIDD--WI----PVPELrTNRCNAGV 458
Cdd:PLN02193 249 FDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGV-SATARLKTLDSY--NIVDkkWFhcstPGDSF-SIRGGAGL 324

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12003207  459 CALNGKLYIVggsdpYGQKGLKNCDV--FDPVTKLWTSCAPLNIR---RHQSAVCELGGYLYIIGG 519
Cdd:PLN02193 325 EVVQGKVWVV-----YGFNGCEVDDVhyYDPVQDKWTQVETFGVRpseRSVFASAAVGKHIVIFGG 385
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 28-120 9.59e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 42.25  E-value: 9.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  28 SGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL-VKDVY 106
Cdd:cd18286  14 NGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLPDDVnLGELL 93

                        90
                ....*....|....
gi 12003207 107 SAAKKLKMDRVKQV 120
Cdd:cd18286  94 SLADMYGLDGLKDV 107
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 134-220 1.06e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 41.93  E-value: 1.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 134 CISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKLYTKVINWVQRSIWENGDS 212
Cdd:cd18444   7 CLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVaKLLASDDLNVPSEETIFHALLLWVKHDLPERKKH 86


                ....*...
gi 12003207 213 LEELMEEV 220
Cdd:cd18444  87 LAKLLALI 94
Kelch_6 pfam13964
Kelch motif;
595-634 1.46e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 39.63  E-value: 1.46e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 12003207   595 PRSNAGIATVGNTIYAVGGF-DGNEFLNTVEVYNLESNEWS 634
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWE 41
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-112 1.54e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 41.36  E-value: 1.54e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  11 DENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDdlnpeAVEVLLNYA 90
Cdd:cd18219   1 DTQYSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSVAGQVVELNFIRAD-----IFAEILNYI 75

                        90       100
                ....*....|....*....|...
gi 12003207  91 YTAQL-KADKELVKDVYSAAKKL 112
Cdd:cd18219  76 YSSKIvRVRSDLLEELIKSGQLL 98
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 129-221 1.80e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 40.94  E-value: 1.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 129 MDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLK-LEVMLEDNVCLPSNGKLYTKVINWVQRSIW 207
Cdd:cd18460   1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRlLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                        90
                ....*....|....
gi 12003207 208 ENGDSLEELMEEVQ 221
Cdd:cd18460  81 HRQHFWPELLQHVR 94
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 20-117 2.05e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 41.04  E-value: 2.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  20 AKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVkfdDLNPEAVEVLLNYAYTAQLKADK 99
Cdd:cd18262   7 GEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFRERLLGSNGPLPPLSL---EVTPVGWEAVLTFAYTGVLGRNP 83

                        90
                ....*....|....*...
gi 12003207 100 ELVKDVYSAAKKLKMDRV 117
Cdd:cd18262  84 ATVGDILVAAEALGAPRV 101
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 29-91 2.24e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 41.22  E-value: 2.24e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12003207  29 GQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNP--EAVEVLLNYAY 91
Cdd:cd18309  18 GDFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVPsrQAFDSLLRYIY 82
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-118 2.26e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 40.94  E-value: 2.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  27 KSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNsdSDPHgISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVY 106
Cdd:cd18226  18 KQSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLS--KNPN-TDAVTLDHVSYSVFQHLLEFLYTSEFFVYENEIPLVL 94

                        90
                ....*....|...
gi 12003207 107 SAAKKLK-MDRVK 118
Cdd:cd18226  95 EAAKFLDiIDAVK 107
Kelch_3 pfam13415
Galactose oxidase, central domain;
605-636 3.23e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.81  E-value: 3.23e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 12003207   605 GNTIYAVGG--FDGNEFLNTVEVYNLESNEWSPY 636
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQI 34
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 134-217 3.74e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 39.99  E-value: 3.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 134 CISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKLYTKVINWVQRSIWENGDS 212
Cdd:cd18455   5 CIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLkELLSRDKLNVGNEEYIFEAVLRWVRHDPEERKVH 84


                ....*
gi 12003207 213 LEELM 217
Cdd:cd18455  85 LKDLM 89
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 128-203 4.54e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 40.03  E-value: 4.54e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12003207 128 RMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVML-EDNVCLPSNGKLYTKVINWVQ 203
Cdd:cd18447   1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLnQDTLTVRAEDQVYDAAVRWLK 77
Kelch_6 pfam13964
Kelch motif;
357-405 5.24e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.09  E-value: 5.24e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 12003207   357 ARSGLGTAEMNGKLIAAGGY-NREECLRTVECYNPHTDHWSFLAPMRTPR 405
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 29-121 7.25e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 39.53  E-value: 7.25e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  29 GQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKEL-VKDVYS 107
Cdd:cd18300   7 GLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEDGdCVGLIV 86

                        90
                ....*....|....
gi 12003207 108 AAKKLKMDRVKQVC 121
Cdd:cd18300  87 LANRLCLPRLVALC 100
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 130-220 8.35e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 39.32  E-value: 8.35e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 130 DVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKLYTKVINWVQRSIWE 208
Cdd:cd18468   1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIvEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                        90
                ....*....|..
gi 12003207 209 NGDSLEELMEEV 220
Cdd:cd18468  81 RKQHIAELLAVV 92
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 129-216 9.47e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 39.07  E-value: 9.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 129 MDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLE-DNVCLPSNGKLYTKVINWVQRSIW 207
Cdd:cd18483   1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNsDDLNVEKEEHVYESIIHWFEHEQS 80


                ....*....
gi 12003207 208 ENGDSLEEL 216
Cdd:cd18483  81 KREMHLPEI 89
Kelch_4 pfam13418
Galactose oxidase, central domain;
501-545 9.76e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.21  E-value: 9.76e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 12003207   501 RRHQSAVCELGGYLYIIGGaESWNC--LNTVERYNPENNTWTLIAPM 545
Cdd:pfam13418   2 RAYHTSTSIPDDTIYLFGG-EGEDGtlLSDLWVFDLSTNEWTRLGSL 47
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-121 1.02e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 39.44  E-value: 1.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSdphgISHVKFDDLNPEAVEVLLNYAYTAQLKADKE 100
Cdd:cd18216  10 QLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHDN----LIHLDQDMVSPTVFQQILDFIYTGKLLDSLF 85

                        90       100
                ....*....|....*....|....
gi 12003207 101 LV---KDVYSAAKKLKMDRVKQVC 121
Cdd:cd18216  86 EEpnlSEVLAAANYLQLPDLAALC 109
Kelch_6 pfam13964
Kelch motif;
548-596 1.02e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.31  E-value: 1.02e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 12003207   548 ARRGAGVAVLNGKLFVCGGFDGSH-AISCVEMYDPTRNEWKMMGNMTSPR 596
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASpALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-121 1.36e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 39.12  E-value: 1.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  21 KLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSdphgISHVKFDDLNPEAVEVLLNYAYTAQL----K 96
Cdd:cd18333  11 QLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHDN----LINLDHEMVSPGIFRLILDYIYTGRLsegdP 86

                        90       100
                ....*....|....*....|....*
gi 12003207  97 ADKELVKDVYSAAKKLKMDRVKQVC 121
Cdd:cd18333  87 GSEQNLGAVLAAASYLQIPDLVALC 111
Kelch_4 pfam13418
Galactose oxidase, central domain;
595-635 1.46e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.82  E-value: 1.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 12003207   595 PRSN-AGIATVGNTIYAVGGFDGN-EFLNTVEVYNLESNEWSP 635
Cdd:pfam13418   1 PRAYhTSTSIPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWTR 43
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-125 1.56e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 38.43  E-value: 1.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  45 AHRAVLACCSPYLFEIFNSDSdPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDY 124
Cdd:cd18349  26 AHKYVLAVGSSVFYAMFYGDL-AEVKSEIHIPDVEPAAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPALAKACVNF 104


                .
gi 12003207 125 L 125
Cdd:cd18349 105 L 105
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 595-635 1.79e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 36.55  E-value: 1.79e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 12003207   595 PRSNAGIATVGNTIYAVGGFDGN--EFLNTVEVYNLESNEWSP 635
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLgdLSSSDVLVYDPETNVWTE 43
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 128-221 1.80e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 38.20  E-value: 1.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 128 RMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDNVC----LPSNGKlytKVINWVQ 203
Cdd:cd18469   2 QIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLqvrdEQSRLE---AVLRWVG 78

                        90
                ....*....|....*...
gi 12003207 204 RSIWENGDSLEELMEEVQ 221
Cdd:cd18469  79 HDPQARAAHLPELLSLVH 96
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-124 1.82e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 38.42  E-value: 1.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  11 DENFIESsvakLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEV---LL 87
Cdd:cd18292   1 SREFLQD----IAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEDPECAAVfekFL 76

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 12003207  88 NYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDY 124
Cdd:cd18292  77 RYLYTGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 129-221 1.86e-03

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 38.23  E-value: 1.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 129 MDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKLYTKVINWVQRSIW 207
Cdd:cd18466   1 IDPANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLvKILRSEELSIEDEYQVFTAAMEWILKDVG 80

                        90
                ....*....|....
gi 12003207 208 ENGDSLEELMEEVQ 221
Cdd:cd18466  81 KRKKHVVEVLEPVR 94
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 501-545 2.01e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 36.55  E-value: 2.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 12003207   501 RRHQSAVCELGGYLYIIGGA-ESWNC-LNTVERYNPENNTWTLIAPM 545
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSdGLGDLsSSDVLVYDPETNVWTEVPRL 47
BTB_POZ_BTBD12_SLX4 cd18288
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-121 2.83e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349597 [Multi-domain]  Cd Length: 116  Bit Score: 37.83  E-value: 2.83e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  15 IESSVAKLNALRKSGQFCDVRLQV-CGHEMLAHRAVLACCSPYLFEIFNS------DSDPHGISHVKFDDLNPEAVEVLL 87
Cdd:cd18288   2 LGKLAADFSAMVNNPHLSDVQFQTdSGEVLYAHSFVLYARCPLLIQMVHSegfsveEEGGVTTRRVLLGDVSGEAARCFL 81

                        90       100       110
                ....*....|....*....|....*....|....
gi 12003207  88 NYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVC 121
Cdd:cd18288  82 QYLYTADTGLPPGLSPHVSELADRFGVSELVHLC 115
Kelch_4 pfam13418
Galactose oxidase, central domain;
453-498 3.09e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.05  E-value: 3.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 12003207   453 RCNAGVCAL-NGKLYIVGGSDPYGqKGLKNCDVFDPVTKLWTSCAPL 498
Cdd:pfam13418   2 RAYHTSTSIpDDTIYLFGGEGEDG-TLLSDLWVFDLSTNEWTRLGSL 47
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 128-204 3.43e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 36.60  E-value: 3.43e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12003207 128 RMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVML-EDNVCLPSNGKLYTKVINWVQR 204
Cdd:cd18463   1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYIsNDELVVPKEEEVFEAVMRWVYH 78
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-95 3.75e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 37.66  E-value: 3.75e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12003207  21 KLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIF-NSDSDphgISHVKFDDLNPEAVEVLLNYAYTAQL 95
Cdd:cd18193  11 QLNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFvHQTSE---CVRLKPTDIQPDIFSYLLHLMYTGKM 83
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 129-203 4.05e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 37.16  E-value: 4.05e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12003207 129 MDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKLYTKVINWVQ 203
Cdd:cd18470   1 INVENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQInEFLIDDDLQLPSEITAFQIAMKWLD 76
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 129-221 4.05e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 37.23  E-value: 4.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207 129 MDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKLYTKVINWVQRSIW 207
Cdd:cd18467   1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELdEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                        90
                ....*....|....
gi 12003207 208 ENGDSLEELMEEVQ 221
Cdd:cd18467  81 ERQKYLAQLLHCVR 94
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-129 4.88e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 37.42  E-value: 4.88e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  45 AHRAVLACCSPYLFEIFNSDSDPHGiSHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDY 124
Cdd:cd18281  40 AHKFVLSIGSAVFDAMFNGGMATTS-AEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEF 118


                ....*
gi 12003207 125 LLSRM 129
Cdd:cd18281 119 LKKNL 123
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-125 6.12e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 36.99  E-value: 6.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  45 AHRAVLACCSPYLFEIFNSDSDPHGiSHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDY 124
Cdd:cd18282  25 AHKYVLATGSSVFYAMFYGGLAENK-NEIEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLARACVQF 103


                .
gi 12003207 125 L 125
Cdd:cd18282 104 L 104
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 549-587 6.13e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 35.00  E-value: 6.13e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 12003207   549 RRGAGVAVLNGKLFVCGGFDGSHAISCVEM--YDPTRNEWK 587
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLGDLSSSDVlvYDPETNVWT 42
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 22-96 6.98e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 37.29  E-value: 6.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12003207  22 LNALRKSGQFC-DVRLQV-CGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVK--FDDLNP------EAVEVLLNYAY 91
Cdd:cd18310   8 ENLLDSPDLFYsDAEIIVeGGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKleLRELIPggivgyDAFMLVLSYLY 87


                ....*
gi 12003207  92 TAQLK 96
Cdd:cd18310  88 SGRLR 92
Kelch_3 pfam13415
Galactose oxidase, central domain;
558-602 7.41e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.96  E-value: 7.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 12003207   558 NGKLFVCGG--FDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIA 602
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSAT 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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