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MULTISPECIES: transcription termination/antitermination protein NusG [unclassified Flavonifractor]
transcription termination/antitermination protein NusG( domain architecture ID 11415705)
transcription termination/antitermination protein NusG (N-Utilization Substance G) is involved in transcription elongation and termination in bacteria
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
NusG | COG0250 | Transcription termination/antitermination protein NusG [Transcription]; |
1-172 | 8.53e-69 | ||||
Transcription termination/antitermination protein NusG [Transcription]; : Pssm-ID: 440020 [Multi-domain] Cd Length: 171 Bit Score: 206.21 E-value: 8.53e-69
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Name | Accession | Description | Interval | E-value | ||||
NusG | COG0250 | Transcription termination/antitermination protein NusG [Transcription]; |
1-172 | 8.53e-69 | ||||
Transcription termination/antitermination protein NusG [Transcription]; Pssm-ID: 440020 [Multi-domain] Cd Length: 171 Bit Score: 206.21 E-value: 8.53e-69
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nusG | TIGR00922 | transcription termination/antitermination factor NusG; NusG proteins are transcription factors ... |
7-170 | 5.10e-63 | ||||
transcription termination/antitermination factor NusG; NusG proteins are transcription factors which are aparrently universal in prokaryotes (archaea and eukaryotes have homologs that may have related functions). The essential components of these factors include an N-terminal RNP-like (ribonucleoprotein) domain and a C-terminal KOW motif (pfam00467) believed to be a nucleic acid binding domain. In E. coli, NusA has been shown to interact with RNA polymerase and termination factor Rho. This model covers a wide variety of bacterial species but excludes mycoplasmas which are covered by a separate model (TIGR01956).The function of all of these NusG proteins is likely to be the same at the level of interaction with RNA and other protein factors to affect termination; however different species may utilize NusG towards different processes and in combination with different suites of affector proteins.In E. coli, NusG promotes rho-dependent termination. It is an essential gene. In Streptomyces virginiae and related species, an additional N-terminal sequence is also present and is suggested to play a role in butyrolactone-mediated autoregulation. In Thermotoga maritima, NusG has a long insert, fails to substitute for E. coli NusG (with or without the long insert), is a large 0.7 % of total cellular protein, and has a general, sequence non-specific DNA and RNA binding activity that blocks ethidium staining, yet permits transcription.Archaeal proteins once termed NusG share the KOW domain but are actually a ribosomal protein corresponding to L24p in bacterial and L26e in eukaryotes (TIGR00405). [Transcription, Transcription factors] Pssm-ID: 273341 [Multi-domain] Cd Length: 172 Bit Score: 191.75 E-value: 5.10e-63
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NGN_Bact_1 | cd09891 | Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; The ... |
6-108 | 1.24e-51 | ||||
Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; The N-Utilization Substance G (NusG) protein is involved in transcription elongation and termination in bacteria. NusG is essential in Escherichia coli and associates with RNA polymerase elongation and Rho-termination. Homologs of the NusG gene exist in all bacteria. The NusG N-terminal domain (NGN) is similar in all NusG homologs, but its C-terminal domain and the linker that separates these two domains are different. The domain organization of NusG suggests that the common properties of NusG and its homologs are due to their similar NGN domains. Pssm-ID: 193580 [Multi-domain] Cd Length: 107 Bit Score: 160.33 E-value: 1.24e-51
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NGN | smart00738 | In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold; In Spt5p, ... |
6-108 | 5.21e-38 | ||||
In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold; In Spt5p, this domain may confer affinity for Spt4p.Spt4p Pssm-ID: 197850 [Multi-domain] Cd Length: 106 Bit Score: 125.95 E-value: 5.21e-38
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NusG | pfam02357 | Transcription termination factor nusG; |
6-108 | 8.08e-35 | ||||
Transcription termination factor nusG; Pssm-ID: 426736 [Multi-domain] Cd Length: 96 Bit Score: 117.33 E-value: 8.08e-35
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antiterm_LoaP | NF033641 | antiterminator LoaP; LoaP is a paralog of NusG with an extensive presence in Firmicutes. The ... |
7-171 | 6.02e-20 | ||||
antiterminator LoaP; LoaP is a paralog of NusG with an extensive presence in Firmicutes. The founding member, from Bacillus amyloliquefaciens, was shown to serve as an antiterminator for the transcription of genes involved in antibiotic biosynthesis. Pssm-ID: 468124 [Multi-domain] Cd Length: 166 Bit Score: 81.28 E-value: 6.02e-20
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antiterm_UpxY | NF033644 | UpxY family transcription antiterminator; The UpxY family of NusG-related transcription ... |
7-153 | 4.90e-10 | ||||
UpxY family transcription antiterminator; The UpxY family of NusG-related transcription antiterminators was described originally from a paralogous family of eight members from Bacteriodes fragilis, UpaY to UphY, each of which was associated with a distinct capsular polysaccharide biosynthesis locus. There is no UpxY protein per se. Pssm-ID: 468125 [Multi-domain] Cd Length: 162 Bit Score: 55.17 E-value: 4.90e-10
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rfaH | PRK09014 | transcription/translation regulatory transformer protein RfaH; |
43-133 | 1.28e-03 | ||||
transcription/translation regulatory transformer protein RfaH; Pssm-ID: 181611 [Multi-domain] Cd Length: 162 Bit Score: 37.56 E-value: 1.28e-03
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Name | Accession | Description | Interval | E-value | |||||
NusG | COG0250 | Transcription termination/antitermination protein NusG [Transcription]; |
1-172 | 8.53e-69 | |||||
Transcription termination/antitermination protein NusG [Transcription]; Pssm-ID: 440020 [Multi-domain] Cd Length: 171 Bit Score: 206.21 E-value: 8.53e-69
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nusG | TIGR00922 | transcription termination/antitermination factor NusG; NusG proteins are transcription factors ... |
7-170 | 5.10e-63 | |||||
transcription termination/antitermination factor NusG; NusG proteins are transcription factors which are aparrently universal in prokaryotes (archaea and eukaryotes have homologs that may have related functions). The essential components of these factors include an N-terminal RNP-like (ribonucleoprotein) domain and a C-terminal KOW motif (pfam00467) believed to be a nucleic acid binding domain. In E. coli, NusA has been shown to interact with RNA polymerase and termination factor Rho. This model covers a wide variety of bacterial species but excludes mycoplasmas which are covered by a separate model (TIGR01956).The function of all of these NusG proteins is likely to be the same at the level of interaction with RNA and other protein factors to affect termination; however different species may utilize NusG towards different processes and in combination with different suites of affector proteins.In E. coli, NusG promotes rho-dependent termination. It is an essential gene. In Streptomyces virginiae and related species, an additional N-terminal sequence is also present and is suggested to play a role in butyrolactone-mediated autoregulation. In Thermotoga maritima, NusG has a long insert, fails to substitute for E. coli NusG (with or without the long insert), is a large 0.7 % of total cellular protein, and has a general, sequence non-specific DNA and RNA binding activity that blocks ethidium staining, yet permits transcription.Archaeal proteins once termed NusG share the KOW domain but are actually a ribosomal protein corresponding to L24p in bacterial and L26e in eukaryotes (TIGR00405). [Transcription, Transcription factors] Pssm-ID: 273341 [Multi-domain] Cd Length: 172 Bit Score: 191.75 E-value: 5.10e-63
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NGN_Bact_1 | cd09891 | Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; The ... |
6-108 | 1.24e-51 | |||||
Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; The N-Utilization Substance G (NusG) protein is involved in transcription elongation and termination in bacteria. NusG is essential in Escherichia coli and associates with RNA polymerase elongation and Rho-termination. Homologs of the NusG gene exist in all bacteria. The NusG N-terminal domain (NGN) is similar in all NusG homologs, but its C-terminal domain and the linker that separates these two domains are different. The domain organization of NusG suggests that the common properties of NusG and its homologs are due to their similar NGN domains. Pssm-ID: 193580 [Multi-domain] Cd Length: 107 Bit Score: 160.33 E-value: 1.24e-51
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NGN | smart00738 | In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold; In Spt5p, ... |
6-108 | 5.21e-38 | |||||
In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold; In Spt5p, this domain may confer affinity for Spt4p.Spt4p Pssm-ID: 197850 [Multi-domain] Cd Length: 106 Bit Score: 125.95 E-value: 5.21e-38
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NusG | pfam02357 | Transcription termination factor nusG; |
6-108 | 8.08e-35 | |||||
Transcription termination factor nusG; Pssm-ID: 426736 [Multi-domain] Cd Length: 96 Bit Score: 117.33 E-value: 8.08e-35
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NGN | cd08000 | N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; The N-Utilization ... |
6-108 | 4.20e-23 | |||||
N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; The N-Utilization Substance G (NusG) and its eukaryotic homolog Spt5 are involved in transcription elongation and termination. NusG contains an NGN domain at its N-terminus and Kyrpides Ouzounis and Woese (KOW) repeats at its C-terminus in bacteria and archaea. The eukaryotic ortholog, Spt5, is a large protein composed of an acidic N-terminus, an NGN domain, and multiple KOW motifs at its C-terminus. Spt5 forms a Spt4-Spt5 complex that is an essential RNA Polymerase II elongation factor. NusG was originally discovered as an N-dependent antitermination enhancing activity in Escherichia coli and has a variety of functions, such as being involved in RNA polymerase elongation and Rho-termination in bacteria. Orthologs of the NusG gene exist in all bacteria, but its functions and requirements are different. The diverse activities suggest that, after diverging from a common ancestor, NusG proteins became specialized in different bacteria. Pssm-ID: 193574 [Multi-domain] Cd Length: 99 Bit Score: 87.76 E-value: 4.20e-23
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KOW_NusG | cd06091 | NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; KOW_NusG motif ... |
116-171 | 8.22e-21 | |||||
NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; KOW_NusG motif is one of the two domains of N-Utilization Substance G (NusG) a transcription elongation and Rho-termination factor in bacteria and archaea. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. The eukaryotic ortholog of NusG is Spt5 with multiple KOW motifs at its C-terminus. Pssm-ID: 240515 [Multi-domain] Cd Length: 56 Bit Score: 80.58 E-value: 8.22e-21
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antiterm_LoaP | NF033641 | antiterminator LoaP; LoaP is a paralog of NusG with an extensive presence in Firmicutes. The ... |
7-171 | 6.02e-20 | |||||
antiterminator LoaP; LoaP is a paralog of NusG with an extensive presence in Firmicutes. The founding member, from Bacillus amyloliquefaciens, was shown to serve as an antiterminator for the transcription of genes involved in antibiotic biosynthesis. Pssm-ID: 468124 [Multi-domain] Cd Length: 166 Bit Score: 81.28 E-value: 6.02e-20
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NGN_SP_RfaH | cd09892 | N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; ... |
7-108 | 3.36e-15 | |||||
N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; RfaH is an operon-specific virulence regulator, thought to have arisen from an early duplication of N-Utilization Substance G (NusG). Paralogs of eubacterial NusG, NusG SP (Specialized Paralog of NusG), are more diverse and often found as the first ORF in operons encoding secreted proteins and LPS biosynthesis genes. NusG SP family members are operon-specific transcriptional antitermination factors. NusG is essential in Escherichia coli and is associated with RNA polymerase elongation and Rho-termination in bacteria. In contrast, RfaH is a non-essential protein that controls expression of operons containing an ops (operon polarity suppressor) element in their transcribed DNA. RfaH and NusG are different in their response to Rho-dependent terminators and regulatory targets. The NusG N-terminal (NGN) domain is quite similar in all NusG orthologs, but its C-terminal domains and the linker that separate these two domains are different. The domain organization of NusG and its homologs suggest that the common properties of NusG and RfaH are due to their similar NGN domains. Pssm-ID: 193581 [Multi-domain] Cd Length: 96 Bit Score: 67.20 E-value: 3.36e-15
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RfaH | TIGR01955 | transcription elongation factor/antiterminator RfaH; This model represents the transcription ... |
7-170 | 5.91e-14 | |||||
transcription elongation factor/antiterminator RfaH; This model represents the transcription elongation factor/antiterminator, RfaH. This protein is most closely related to the transcriptional termination/antitermination protein NusG (TIGR00922) and contains the KOW motif (pfam00467). This protein appears to be limited to the gamma proteobacteria. In E. coli, this gene appears to control the expression of haemolysin, sex factor and lipopolysaccharide genes. [Transcription, Transcription factors] Pssm-ID: 131010 [Multi-domain] Cd Length: 159 Bit Score: 65.56 E-value: 5.91e-14
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NusG_myco | TIGR01956 | NusG family protein; This model represents a family of Mycoplasma proteins orthologous to the ... |
6-169 | 1.07e-12 | |||||
NusG family protein; This model represents a family of Mycoplasma proteins orthologous to the bacterial transcription termination/antitermination factor NusG. These sequences from Mycoplasma are notably diverged (long branches in a Neighbor-joining phylogenetic tree) from the bacterial species. And although NusA and ribosomal protein S10 (NusE) appear to be present, NusB may be absent in Mycoplasmas calling into question whether these species have a functional Nus system including this family as a member. Pssm-ID: 273895 [Multi-domain] Cd Length: 258 Bit Score: 63.83 E-value: 1.07e-12
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NGN_plant | cd09890 | Plant N-Utilization Substance G (NusG) N-terminal (NGN) domain; The N-Utilization Substance G ... |
7-94 | 4.15e-12 | |||||
Plant N-Utilization Substance G (NusG) N-terminal (NGN) domain; The N-Utilization Substance G (NusG) protein and its eukaryotic homolog, Spt5, are involved in transcription elongation and termination. NusG contains a NGN domain at its N-terminus and Kyrpides Ouzounis and Woese (KOW) repeats at its C-terminus in bacteria and archaea. The eukaryotic ortholog, Spt5, is a large protein comprising an acidic N-terminus, an NGN domain, and multiple KOW motifs at its C-terminus. Spt5 forms an Spt4-Spt5 complex that is an essential RNA polymerase II elongation factor. The bacterial infected plants contain bacterial DNA, such as NGN sequences, that can be used to clone the DNA of uncultured organisms. Pssm-ID: 193579 Cd Length: 113 Bit Score: 59.67 E-value: 4.15e-12
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NGN_SP_TaA | cd09893 | N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), TaA; ... |
7-108 | 3.80e-11 | |||||
N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), TaA; The N-Utilization Substance G (NusG) protein is involved in transcription elongation and termination. NusG is essential in Escherichia coli and is associated with RNA polymerase elongation and Rho-termination in bacteria. Paralogs of eubacterial NusG, NusG SP (Specialized Paralog of NusG), are more diverse and often found as the first ORF in operons encoding secreted proteins and LPS biosynthesis genes. NusG SP family members are operon-specific transcriptional antiterminationn factors. TaA is a NusG SP factor that is required for synthesis of a polyketide antibiotic TA in Myxococcus xanthus. Orthologs of the NusG gene exist in all bacteria, but its functions and requirements are different. The NusG N-terminal (NGN) domain is quite similar in all NusG orthologs, but its C-terminal domains and the linker that separate these two domains are different. The domain organization of NusG and its orthologs suggest that the common properties of NusG and its orthologs and paralogs are due to their similar NGN domains. Pssm-ID: 193582 [Multi-domain] Cd Length: 95 Bit Score: 56.55 E-value: 3.80e-11
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antiterm_UpxY | NF033644 | UpxY family transcription antiterminator; The UpxY family of NusG-related transcription ... |
7-153 | 4.90e-10 | |||||
UpxY family transcription antiterminator; The UpxY family of NusG-related transcription antiterminators was described originally from a paralogous family of eight members from Bacteriodes fragilis, UpaY to UphY, each of which was associated with a distinct capsular polysaccharide biosynthesis locus. There is no UpxY protein per se. Pssm-ID: 468125 [Multi-domain] Cd Length: 162 Bit Score: 55.17 E-value: 4.90e-10
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NGN_SP | cd09886 | N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP); The ... |
6-108 | 3.96e-09 | |||||
N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP); The N-Utilization Substance G (NusG) protein is involved in transcription elongation and termination. NusG is essential in Escherichia coli and is associated with RNA polymerase elongation and Rho-termination in bacteria. Paralogs of eubacterial NusG, NusG SP (Specialized Paralog of NusG), are more diverse and often found as the first ORF in operons encoding secreted proteins and LPS biosynthesis genes. NusG SP family members are operon-specific transcriptional antitermination factors. The NusG N-terminal (NGN) domain is quite similar in all NusG orthologs, but its C-terminal domains and the linker that separate these two domains are different. The domain organization of NusG and its orthologs suggest that the common properties of NusG and its orthologs and paralogs are due to their similar NGN domains. Pssm-ID: 193575 [Multi-domain] Cd Length: 97 Bit Score: 51.21 E-value: 3.96e-09
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NGN_Bact_2 | cd09889 | Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 2; The ... |
6-106 | 5.50e-09 | |||||
Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 2; The N-Utilization Substance G (NusG) protein is involved in transcription elongation and termination. NusG is essential in Escherichia coli and associates with RNA polymerase elongation and Rho-termination. Paralogs of eubacterial NusG, NusG SP (Specialized Paralog of NusG), are more diverse and often found as the first ORF in operons encoding secreted proteins and LPS biosynthesis genes. NusG SP family members are operon-specific transcriptional antitermination factors. The NusG N-terminal domain (NGN) is quite similar in all NusG orthologs, but its C-terminal domain and the linker that separates these two domains are different. The domain organization of NusG and its orthologs suggests that the common properties of NusG and its orthologs and paralogs are due to their similar NGN domains. Pssm-ID: 193578 [Multi-domain] Cd Length: 100 Bit Score: 51.17 E-value: 5.50e-09
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NGN_SP_UpxY | cd09895 | N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; ... |
6-108 | 2.81e-06 | |||||
N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; The N-Utilization Substance G (NusG) proteins are involved in transcription elongation and termination. NusG is essential in Escherichia coli and is associated with RNA polymerase elongation and Rho-termination. Paralogs of eubacterial NusG, NusG SP (Specialized Paralog of NusG), are more diverse and often found as the first ORF in operons encoding secreted proteins and LPS (lipopolysaccharide) biosynthesis genes. NusG SP family members are operon-specific transcriptional antitermination factors. UpxY proteins, UpxY proteins, where the x is replaced by the letter designation of the specific polysaccharide (UpaY to UphY), are a family of NusG SP factors that act specifically in transcriptional antitermination of operons from which they are encoded. UpxYs are necessary and specific for transcription regulation of the polysaccharide biosynthesis operon. Orthologs of the NusG gene exist in all bacteria, but their functions and requirements are different. The NusG N-terminal (NGN) domain is similar in all NusG orthologs, but its C-terminal domain and the linker that separate these two domains are different. The domain organization of NusG and its orthologs suggests that the common properties of NusG and its orthologs and paralogs are due to their similar NGN domains. Pssm-ID: 193584 [Multi-domain] Cd Length: 95 Bit Score: 43.72 E-value: 2.81e-06
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NGN_SP_AnfA1 | cd09894 | N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), AnFA1; ... |
5-108 | 5.58e-06 | |||||
N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), AnFA1; Regulation of the afp, antifeeding prophage, gene cluster is mediated by AnFA1, a RfaH-like transcriptional antiterminator. RfaH is an operon-specific virulence regulator, thought to arisen from an early duplication of N-Utilization Substance G (NusG). NusG is essential in Escherichia coli and is associated with RNA polymerase elongation and Rho-termination in bacteria. Paralogs of eubacterial NusG, NusG SP (Specialized Paralog of NusG), are more diverse and often found as the first ORF in operons encoding secreted proteins and LPS biosynthesis genes. NusG SP family members are operon-specific transcriptional antitermination factors. Orthologs of the NusG gene exist in all bacteria, but their functions and requirements are different. The NusG N-terminal domain (NGN) is similar in all NusG orthologs, but its C-terminal domain and the linker that separate these two domains are different. The domain organization of NusG and its orthologs suggests that the common properties of NusG and its orthologs and paralogs are due to their similar NGN domains. Pssm-ID: 193583 [Multi-domain] Cd Length: 99 Bit Score: 43.04 E-value: 5.58e-06
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rfaH | PRK09014 | transcription/translation regulatory transformer protein RfaH; |
43-133 | 1.28e-03 | |||||
transcription/translation regulatory transformer protein RfaH; Pssm-ID: 181611 [Multi-domain] Cd Length: 162 Bit Score: 37.56 E-value: 1.28e-03
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KOW | cd00380 | KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); KOW domain is known ... |
122-170 | 5.89e-03 | |||||
KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. The KOW motif contains an invariants glycine residue and comprises alternating blocks of hydrophilic and hydrophobic residues. Pssm-ID: 240504 Cd Length: 49 Bit Score: 33.35 E-value: 5.89e-03
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Blast search parameters | ||||
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