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Conserved domains on  [gi|1199428313|ref|WP_087168779|]
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MULTISPECIES: type II toxin-antitoxin system RelE/ParE family toxin [Clostridia]

Protein Classification

type II toxin-antitoxin system RelE/ParE family toxin( domain architecture ID 10007814)

type II toxin-antitoxin (TA) system RelE/ParE family toxin is the RelE/ParE-like toxin component of a type II toxin-antitoxin system, its activity is attenuated by interaction with its cognate antitoxin

Gene Ontology:  GO:0110001|GO:0090729
PubMed:  20143871|20487277|28279904|15718296

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
4-96 4.50e-18

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


:

Pssm-ID: 442885  Cd Length: 96  Bit Score: 72.23  E-value: 4.50e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199428313   4 YSVKLMSRALRDLDGIYDYIAHTlLEPGTALKLVGRIEDAILSLETMPYRCpeRRRGAYANRGYRQLFVENYTAVFRIDE 83
Cdd:COG3668     1 MKVRWTPEAEADLEEIYDYIAED-WGPEAAERYLDEIEEAIELLAEFPELG--RPRPELRVPGLRELVVGPYVIFYRVDD 77

                          90
                  ....*....|...
gi 1199428313  84 akKTVIVVTVRYS 96
Cdd:COG3668    78 --DTVEILRVLHG 88
 
Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
4-96 4.50e-18

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


Pssm-ID: 442885  Cd Length: 96  Bit Score: 72.23  E-value: 4.50e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199428313   4 YSVKLMSRALRDLDGIYDYIAHTlLEPGTALKLVGRIEDAILSLETMPYRCpeRRRGAYANRGYRQLFVENYTAVFRIDE 83
Cdd:COG3668     1 MKVRWTPEAEADLEEIYDYIAED-WGPEAAERYLDEIEEAIELLAEFPELG--RPRPELRVPGLRELVVGPYVIFYRVDD 77

                          90
                  ....*....|...
gi 1199428313  84 akKTVIVVTVRYS 96
Cdd:COG3668    78 --DTVEILRVLHG 88
ParE_toxin pfam05016
ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II ...
 6-94 2.69e-12

ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.


Pssm-ID: 398610 [Multi-domain]  Cd Length: 91  Bit Score: 57.44  E-value: 2.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199428313   6 VKLMSRALRDLDGIYDYIAhtLLEPGTALKLVGRIEDAILSLETMPYRCPERRRGAYanRGYRQLFVENYTAVFRIDEAK 85
Cdd:pfam05016   1 VILTPKALKDLKKIADYIA--QDNPDAAERFLKALEEALELLAENPALGRPLPEGGL--KGLRRIRIGDYRIIYRIDDDD 76


                  ....*....
gi 1199428313  86 KTVIVVTVR 94
Cdd:pfam05016  77 LVILILRVG 85
 
Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
4-96 4.50e-18

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


Pssm-ID: 442885  Cd Length: 96  Bit Score: 72.23  E-value: 4.50e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199428313   4 YSVKLMSRALRDLDGIYDYIAHTlLEPGTALKLVGRIEDAILSLETMPYRCpeRRRGAYANRGYRQLFVENYTAVFRIDE 83
Cdd:COG3668     1 MKVRWTPEAEADLEEIYDYIAED-WGPEAAERYLDEIEEAIELLAEFPELG--RPRPELRVPGLRELVVGPYVIFYRVDD 77

                          90
                  ....*....|...
gi 1199428313  84 akKTVIVVTVRYS 96
Cdd:COG3668    78 --DTVEILRVLHG 88
ParE_toxin pfam05016
ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II ...
 6-94 2.69e-12

ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.


Pssm-ID: 398610 [Multi-domain]  Cd Length: 91  Bit Score: 57.44  E-value: 2.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199428313   6 VKLMSRALRDLDGIYDYIAhtLLEPGTALKLVGRIEDAILSLETMPYRCPERRRGAYanRGYRQLFVENYTAVFRIDEAK 85
Cdd:pfam05016   1 VILTPKALKDLKKIADYIA--QDNPDAAERFLKALEEALELLAENPALGRPLPEGGL--KGLRRIRIGDYRIIYRIDDDD 76


                  ....*....
gi 1199428313  86 KTVIVVTVR 94
Cdd:pfam05016  77 LVILILRVG 85
RelE COG2026
mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system [Defense ...
 3-93 3.25e-04

mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system [Defense mechanisms];


Pssm-ID: 441629  Cd Length: 85  Bit Score: 36.33  E-value: 3.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1199428313   3 KYSVKLMSRALRDLDGiydyiahtlLEPGTALklvgRIEDAILSLETMPYRCPERRRGAYanRGYRQLFVENYTAVFRID 82
Cdd:COG2026     1 MYKVEFTPRALKDLKK---------LDKKVQK----RIKKKIEELAENPRPGGKKLKGSL--KGLYRLRVGDYRIIYEID 65

                          90
                  ....*....|.
gi 1199428313  83 EAKKTVIVVTV 93
Cdd:COG2026    66 DDELVVLVLAI 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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