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Conserved domains on  [gi|1197511605|ref|YP_009368304|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Lepilemur hollandorum]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 4.37e-36

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 117.72  E-value: 4.37e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511605  1 MPSISTNIILAFTAALAGMLVFRSHLMSSLLCLEGMMLSMFVLSTLTIMNLHSTMSFIMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1197511605 81 MSNTYGLDLIQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 4.37e-36

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 117.72  E-value: 4.37e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511605  1 MPSISTNIILAFTAALAGMLVFRSHLMSSLLCLEGMMLSMFVLSTLTIMNLHSTMSFIMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1197511605 81 MSNTYGLDLIQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 4.37e-10

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 51.41  E-value: 4.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511605  3 SISTNIILAFTAALAGMLvFRSHLMSSLLCLEGMMLSMFVLSTLTIMNLHSTMSFIMPILLLVFAACEAAIGLALLVMMS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 1197511605 83 NTYGLDLIQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 4.37e-36

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 117.72  E-value: 4.37e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511605  1 MPSISTNIILAFTAALAGMLVFRSHLMSSLLCLEGMMLSMFVLSTLTIMNLHSTMSFIMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1197511605 81 MSNTYGLDLIQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 11-98 5.18e-22

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 81.93  E-value: 5.18e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511605 11 AFTAALAGMLVFRSHLMSSLLCLEGMMLSMFVLSTLTIMNLHSTMSFIMPILLLVFAACEAAIGLALLVMMSNTYGLDLI 90
Cdd:MTH00126  11 AFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVATARTHGTDRL 90


                 ....*...
gi 1197511605 91 QNLNLLQC 98
Cdd:MTH00126  91 QNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.98e-19

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 74.11  E-value: 6.98e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511605  1 MPSISTNIILAFTAALAGMLVFRSHLMSSLLCLEGMMLSMFVLSTLTIMNLHSTMSFIMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00125   1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                         90
                 ....*....|....*...
gi 1197511605 81 MSNTYGLDLIQNLNLLQC 98
Cdd:MTH00125  81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 8-98 1.10e-16

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 68.48  E-value: 1.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511605  8 IILAFTAALAGMLVFRSHLMSSLLCLEGMMLSMFVLSTLTIMNLHSTMSFIMPILLLVFAACEAAIGLALLVMMSNTYGL 87
Cdd:MTH00067   8 FYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVATTRTHGT 87

                         90
                 ....*....|.
gi 1197511605 88 DLIQNLNLLQC 98
Cdd:MTH00067  88 DHLKNLNLLQC 98
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 9-96 2.18e-12

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 57.65  E-value: 2.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511605  9 ILAFTAALAGMLVFRSHLMSSLLCLEGMMLSMFVLSTLTIMNLHSTMSFIMPILLLVFAACEAAIGLALLVMMSNTYGLD 88
Cdd:MTH00181   6 ISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRTHGSD 85


                 ....*...
gi 1197511605 89 LIQNLNLL 96
Cdd:MTH00181  86 HLLKFNLL 93
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 4.37e-10

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 51.41  E-value: 4.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511605  3 SISTNIILAFTAALAGMLvFRSHLMSSLLCLEGMMLSMFVLSTLTIMNLHSTMSFIMPILLLVFAACEAAIGLALLVMMS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 1197511605 83 NTYGLDLIQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 1.48e-09

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 50.30  E-value: 1.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511605  1 MPSISTNIILAFTAALAGMLVFRSHLMSSLLCLEGMMLSMFVLSTLTIMNLHSTMSFIMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00043   1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                         90
                 ....*....|....*..
gi 1197511605 81 MSNTYGLDLIQNLNLLQ 97
Cdd:MTH00043  81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 8-98 2.42e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 44.58  E-value: 2.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511605  8 IILAFTAALAGMLVFRSHLMSSLLCLEGMMLSMFVLSTLTIMNLHStmSFIMPILLLVFAACEAAIGLALLVMMSNTYGL 87
Cdd:MTH00188   9 ILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEK--ELYLSLVLLTFAACEASVGLALLVSLIRSHGS 86

                         90
                 ....*....|.
gi 1197511605 88 DLIQNLNLLQC 98
Cdd:MTH00188  87 DYVSSLNLIKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 9-98 3.20e-06

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 41.75  E-value: 3.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511605  9 ILAFTAALAGMLVFRSHLMSSLLCLEGMMLSMFVLSTLTIMNLHSTMSFIMpiLLLVFAACEAAIGLALLVMMSNTYGLD 88
Cdd:MTH00149  10 LFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMMFSSSGLISFSSYLFL--IILTFGACEASLGLSLLVSLIRLHGND 87

                         90
                 ....*....|
gi 1197511605 89 LIQNLNLLQC 98
Cdd:MTH00149  88 YVSSLSSLKF 97
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 3.88e-06

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 41.66  E-value: 3.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511605  1 MPSISTNIILAFTAALAGMLVFRSHLMSSLLCLEGMMLSMFVLSTLTIMNLHSTMSFiMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00013   1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFANQVNGM-LAIVLLTFGACEASLGLSLLVL 79

                         90
                 ....*....|....*...
gi 1197511605 81 MSNTYGLDLIQNLNLLQC 98
Cdd:MTH00013  80 MTRSYGNDMLKSLTSNKC 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 8-92 2.45e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 39.37  E-value: 2.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511605  8 IILAFTAALAGMLVFRSHLMSSLLCLEGMMLSMFVLstLTIMNLHSTMSFIMPILLLVFAACEAAIGLALLVMMSNTYGL 87
Cdd:MTH00162   7 FLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFL--LFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIRSHGN 84


                 ....*
gi 1197511605 88 DLIQN 92
Cdd:MTH00162  85 DYFSS 89
ND4L MTH00180
NADH dehydrogenase subunit 4L; Provisional
 9-97 1.04e-03

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177231  Cd Length: 99  Bit Score: 35.01  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511605  9 ILAFTAALAGMLVFRSHLMSSLLCLEGMMLSMFVLSTLTIMNLHSTMSFIMPILLLVFAACEAAIGLALLVMMSNTYGLD 88
Cdd:MTH00180  10 IILFILGVLGIVLNRSNLIIMLMSIELMLLAISLLFLINSVAIDNLIGQIFTIMILTVAAAESAIGLAILVAYYRIRGTI 89


                 ....*....
gi 1197511605 89 LIQNLNLLQ 97
Cdd:MTH00180  90 AVKSLNLLR 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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