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Conserved domains on  [gi|1197511524|ref|YP_009368229|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Lepilemur wrightae]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 6.25e-73

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 216.98  E-value: 6.25e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511524   1 MAYVMFLLSVIFVLGCMSFSSKPSPIYGGVGLIVSGAVGCMIIVGFGGAFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511524  81 TWGSSVVVLGSMLVGAIMELLVVVWVVGEGDFEVVVGFGDLEDWIVFMGKEVGVVREDSLGVSSLYNYVSWFVVIAGWFL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|..
gi 1197511524 161 FMSVLIVIEIVR 172
Cdd:MTH00109  162 FIGVFVIIEITR 173
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 6.25e-73

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 216.98  E-value: 6.25e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511524   1 MAYVMFLLSVIFVLGCMSFSSKPSPIYGGVGLIVSGAVGCMIIVGFGGAFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511524  81 TWGSSVVVLGSMLVGAIMELLVVVWVVGEGDFEVVVGFGDLEDWIVFMGKEVGVVREDSLGVSSLYNYVSWFVVIAGWFL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|..
gi 1197511524 161 FMSVLIVIEIVR 172
Cdd:MTH00109  162 FIGVFVIIEITR 173
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 8.53e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 48.65  E-value: 8.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511524  21 SKPSPIYGGVGLIVSGAVGCMIIVGFGGAFVGLMVFLVYLGGMLVVFGYTTAMATEEYPETWGSSVVVLGSMLVGAIMEL 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLLLA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511524 101 LVVVWVVGEGDFEVVVGFGdledwivfmgkeVGVVREDSLGVSSLYNYVsWFVVIAGWFLFMSVLIVIEI 170
Cdd:pfam00499  85 LLLLVLLSASLTPAAAAAA------------PDVGNIEAIGELLFTDYL-LPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 6.25e-73

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 216.98  E-value: 6.25e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511524   1 MAYVMFLLSVIFVLGCMSFSSKPSPIYGGVGLIVSGAVGCMIIVGFGGAFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511524  81 TWGSSVVVLGSMLVGAIMELLVVVWVVGEGDFEVVVGFGDLEDWIVFMGKEVGVVREDSLGVSSLYNYVSWFVVIAGWFL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|..
gi 1197511524 161 FMSVLIVIEIVR 172
Cdd:MTH00109  162 FIGVFVIIEITR 173
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-172 1.21e-31

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 111.77  E-value: 1.21e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511524   1 MAYVMFLLSVIFVLGCMSFSSKPSPIYGGVGLIVSGAVGCMIIVGFGGAFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138    1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511524  81 TWGsSVVVLGSMLVGAIMELLVVVWVVG---EGDFEVVVGFGDLedwivfmgkevGVVREDSLGVSSLYNYVSWFVVIAG 157
Cdd:MTH00138   81 SWG-SWSVLGYVVGYLVGVVLAAGLFWGgwyEGSWVVVDELKEF-----------SVLRGDVGGVALMYSSGGGMLVICA 148

                         170
                  ....*....|....*
gi 1197511524 158 WFLFMSVLIVIEIVR 172
Cdd:MTH00138  149 WVLLLTLFVVLELTR 163
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-172 2.67e-28

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 103.00  E-value: 2.67e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511524   1 MAYVMFLLSVIFVLGCMSFSSKPSPIYGGVGLIVSGAVGCMIIVGFGGAFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065    1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511524  81 TWGSSVVVlgsMLVGAIMELLVVVWVvgegdfeVVVGFGDLEDWIVFMGKEVGVVREDSLGVSSLYNYVSWFVVIAGWFL 160
Cdd:MTH00065   81 AWGSWSVL---VYVLFYLLLLIVGYI-------LFGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                         170
                  ....*....|..
gi 1197511524 161 FMSVLIVIEIVR 172
Cdd:MTH00065  151 LLTLFVVLEVTR 162
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-172 2.50e-22

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 87.88  E-value: 2.50e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511524   1 MAYVMFLLSVIFVLGCMSFSSKPSPIYGGVGLIVSGAVGCMIIVGFGGAFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115    1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511524  81 TWGSSVVVLGsmLVGAIMELLVVVWVVGEGDFEVVVGFGDLEDWIVFmgkevgVVREDSLGVSSLYNYVSWFVVIAGWFL 160
Cdd:MTH00115   81 AWGDWGVVGY--VVGFVLVVVVVGVVVGGLWGMEGVGVVTVDSGGLF------VVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                         170
                  ....*....|..
gi 1197511524 161 FMSVLIVIEIVR 172
Cdd:MTH00115  153 LLTLFVVLELVR 164
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-172 3.27e-13

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 63.85  E-value: 3.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511524   1 MAYVMFLLSVIFVLGCMSFSSKPSPIYGGVGLIVSGAVGCMIIVGFGGAFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214    1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511524  81 TWGSsvvvlgsmlvgaIMELLVVVWVVGEGDFEVVVGFGDLEDWIVFMGKEVGVVreDSLGVSSLYNYVSWFVVIAGWFL 160
Cdd:MTH00214   81 SWGG------------WSVLLFFLFYLLGLGFVGFYFYGGWEMLSWMGVDEANNL--DLSGVSDLYSRGFFLLLLGGVVL 146

                         170
                  ....*....|..
gi 1197511524 161 FMSVLIVIEIVR 172
Cdd:MTH00214  147 FLVLFVVLELVR 158
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 24-172 6.04e-10

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 54.91  E-value: 6.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511524  24 SPIYGGVGLIVSGAVGCMIIVGFGGAFVGLMVFLVYLGGMLVVFGYTTAMATEEYPetwgsSVVVLGSMLVgaiMELLVV 103
Cdd:MTH00045   22 SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYP-----SVSNLGEVLV---LSLLLS 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1197511524 104 VWvvgegdfeVVVGFGDLEDWIVFMGKEVGVvrEDSLGVSSLYNYVSWFVVIAGWFLFMSVLIVIEIVR 172
Cdd:MTH00045   94 LW--------VFISFDNFLELSNNNWSLVSL--SDLVGSSELYNSGGLYLLLGGFILLVALVVALVISF 152
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 8.53e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 48.65  E-value: 8.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511524  21 SKPSPIYGGVGLIVSGAVGCMIIVGFGGAFVGLMVFLVYLGGMLVVFGYTTAMATEEYPETWGSSVVVLGSMLVGAIMEL 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLLLA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511524 101 LVVVWVVGEGDFEVVVGFGdledwivfmgkeVGVVREDSLGVSSLYNYVsWFVVIAGWFLFMSVLIVIEI 170
Cdd:pfam00499  85 LLLLVLLSASLTPAAAAAA------------PDVGNIEAIGELLFTDYL-LPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 5-78 1.78e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 39.99  E-value: 1.78e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1197511524   5 MFLLSVIFVLGCMsFSSKPSPIYGGVGLIVSGAVGCMIIVGFGGAFVGLMVFLVYLGGMLVVFGYTTAMATEEY 78
Cdd:MTH00212    4 SLLLSLLLLLMLL-FPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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