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Conserved domains on  [gi|119623992|gb|EAX03587|]
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FK506 binding protein like, isoform CRA_a [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
200-338 5.55e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.81  E-value: 5.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 200 ELETSEKEALAReeraRGTELFRAGNPEGAARCYGRALRLLLtlpppgppERTVLHANLAACQLLLGQPQLAAQSCDRVL 279
Cdd:COG0457    2 ELDPDDAEAYNN----LGLAYRRLGRYEEAIEDYEKALELDP--------DDAEALYNLGLAYLRLGRYEEALADYEQAL 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 280 EREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKV-VIQGKNQDA 338
Cdd:COG0457   70 ELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLAlLELGRYDEA 129
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
200-338 5.55e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.81  E-value: 5.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 200 ELETSEKEALAReeraRGTELFRAGNPEGAARCYGRALRLLLtlpppgppERTVLHANLAACQLLLGQPQLAAQSCDRVL 279
Cdd:COG0457    2 ELDPDDAEAYNN----LGLAYRRLGRYEEAIEDYEKALELDP--------DDAEALYNLGLAYLRLGRYEEALADYEQAL 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 280 EREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKV-VIQGKNQDA 338
Cdd:COG0457   70 ELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLAlLELGRYDEA 129
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 187-348 8.57e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 53.93  E-value: 8.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992  187 LTLASFTQGRDSWELETSE-KEALAREERA-----RGTELFRAGNPEGAARCYGRALRLlltlpppgppERTVLHANLAA 260
Cdd:TIGR02917  96 LARAYLLQGKFQQVLDELPgKTLLDDEGAAellalRGLAYLGLGQLELAQKSYEQALAI----------DPRSLYAKLGL 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992  261 CQLLLGQPQL--AAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKVVIQGKNQDA 338
Cdd:TIGR02917 166 AQLALAENRFdeARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEE 245

                         170
                  ....*....|..
gi 119623992  339 GL--AQGLRKMF 348
Cdd:TIGR02917 246 AEkhADALLKKA 257
TPR_1 pfam00515
Tetratricopeptide repeat;
287-319 1.13e-06

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 44.33  E-value: 1.13e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 119623992  287 KALYRRGVAQAALGNLEKATADLKKVLAIDPKN 319
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 287-319 2.04e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 40.89  E-value: 2.04e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 119623992   287 KALYRRGVAQAALGNLEKATADLKKVLAIDPKN 319
Cdd:smart00028   2 EALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 262-317 2.31e-04

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 42.62  E-value: 2.31e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 119623992 262 QLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDP 317
Cdd:cd24142   10 LLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDP 65
PRK09782 PRK09782
bacteriophage N4 receptor, outer membrane subunit; Provisional
 223-327 1.73e-03

bacteriophage N4 receptor, outer membrane subunit; Provisional


Pssm-ID: 236624 [Multi-domain]  Cd Length: 987  Bit Score: 40.28  E-value: 1.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 223 AGNPEGAARCYGRALRLLLtlpppgppERTVLHANLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAAlGNL 302
Cdd:PRK09782 555 AGNGAARDRWLQQAEQRGL--------GDNALYWWLHAQRYIPGQPELALNDLTRSLNIAPSANAYVARATIYRQR-HNV 625

                         90       100
                 ....*....|....*....|....*
gi 119623992 303 EKATADLKKVLAIDPKNRAAQEELG 327
Cdd:PRK09782 626 PAAVSDLRAALELEPNNSNYQAALG 650
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
200-338 5.55e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.81  E-value: 5.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 200 ELETSEKEALAReeraRGTELFRAGNPEGAARCYGRALRLLLtlpppgppERTVLHANLAACQLLLGQPQLAAQSCDRVL 279
Cdd:COG0457    2 ELDPDDAEAYNN----LGLAYRRLGRYEEAIEDYEKALELDP--------DDAEALYNLGLAYLRLGRYEEALADYEQAL 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 280 EREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKV-VIQGKNQDA 338
Cdd:COG0457   70 ELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLAlLELGRYDEA 129
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 158-341 2.06e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 71.18  E-value: 2.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 158 ELIEKCLESMCQGEEAELQLPGHSGPPVRLTLASFTQGRDSWELETSEKEALAREERARGTELFRAGNPEGAARCYGRAL 237
Cdd:COG3914   26 LALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRAL 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 238 RLLLtlpppgppERTVLHANLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDP 317
Cdd:COG3914  106 ALNP--------DNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDP 177

                        170       180
                 ....*....|....*....|....
gi 119623992 318 KNRAAQEELGKVVIQGKNQDAGLA 341
Cdd:COG3914  178 DNAEALNNLGNALQDLGRLEEAIA 201
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
215-341 2.92e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.49  E-value: 2.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 215 ARGTELFRAGNPEGAARCYGRALRLLLtlpppgppERTVLHANLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGV 294
Cdd:COG0457   47 NLGLAYLRLGRYEEALADYEQALELDP--------DDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGL 118

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 119623992 295 AQAALGNLEKATADLKKVLAIDPKNRAAQEELGKVVIQGKNQDAGLA 341
Cdd:COG0457  119 ALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALE 165
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 171-323 1.56e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 68.48  E-value: 1.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 171 EEAELQLPGHSGPPVRLTLASFTQGRDSwELETSEKEALAREERA------RGTELFRAGNPEGAARCYGRALRLLLtlp 244
Cdd:COG3914   68 AAAAAALLLLAALLELAALLLQALGRYE-EALALYRRALALNPDNaealfnLGNLLLALGRLEEALAALRRALALNP--- 143

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119623992 245 ppgppERTVLHANLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQ 323
Cdd:COG3914  144 -----DFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAH 217
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 207-342 1.89e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 60.98  E-value: 1.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 207 EALAREERARGTELFRAGNPEGAARCYGRALRLLLtlpppgppERTVLHANLAACQLLLGQPQLAAQSCDRVLEREPGHL 286
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDP--------DNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEP 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 119623992 287 KALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKVVIQGKNQDAGLAQ 342
Cdd:COG4783   73 EARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAA 128
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 220-323 2.39e-11

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 60.40  E-value: 2.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 220 LFRAGNPEGAARCYGRALRLLLtlpppgppERTVLHANLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAAL 299
Cdd:COG4235   27 YLRLGRYDEALAAYEKALRLDP--------DNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQ 98

                         90       100
                 ....*....|....*....|....
gi 119623992 300 GNLEKATADLKKVLAIDPKNRAAQ 323
Cdd:COG4235   99 GDYAEAIAAWQKLLALLPADAPAR 122
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
216-322 2.61e-11

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 62.63  E-value: 2.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 216 RGTELFRAGNPEGAARCYGRALRLLLtlpppgppERTVLHANLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVA 295
Cdd:COG4785   79 RGVAYDSLGDYDLAIADFDQALELDP--------DLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIA 150

                         90       100
                 ....*....|....*....|....*..
gi 119623992 296 QAALGNLEKATADLKKVLAIDPKNRAA 322
Cdd:COG4785  151 LYYLGRYELAIADLEKALELDPNDPER 177
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 255-338 2.09e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 57.71  E-value: 2.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 255 HANLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKV-VIQG 333
Cdd:COG4235   20 WLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAaFQQG 99


                 ....*
gi 119623992 334 KNQDA 338
Cdd:COG4235  100 DYAEA 104
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 201-341 1.22e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 58.20  E-value: 1.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 201 LETSEKEALAREERARGteLFRAGNPEGAARCYGRALRLLLtlpppgppERTVLHANLAACQLLLGQPQLAAQSCDRVLE 280
Cdd:COG2956  103 LELDPDDAEALRLLAEI--YEQEGDWEKAIEVLERLLKLGP--------ENAHAYCELAELYLEQGDYDEAIEALEKALK 172

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119623992 281 REPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKVVIQGKNQDAGLA 341
Cdd:COG2956  173 LDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALE 233
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 205-317 1.26e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 56.51  E-value: 1.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 205 EKEALAREERARGTELFRAGNPEGAARCYGRALRLLLtlpppgppERTVLHANLAACQLLLGQPQLAAQSCDRVLEREPG 284
Cdd:COG5010   49 KLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDP--------NNPELYYNLALLYSRSGDKDEAKEYYEKALALSPD 120

                         90       100       110
                 ....*....|....*....|....*....|...
gi 119623992 285 HLKALYRRGVAQAALGNLEKATADLKKVLAIDP 317
Cdd:COG5010  121 NPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 208-342 1.85e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 55.74  E-value: 1.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 208 ALAREERARGTELFRAGNPEGAARCYGRALRLLLTLPPPGPPERTVLHANLAACQLLLGQPQLAAQSCDRVLEREPGHLK 287
Cdd:COG5010   10 LPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPE 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 119623992 288 ALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKVVIQGKNQDAGLAQ 342
Cdd:COG5010   90 LYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAA 144
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
226-342 3.78e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 56.08  E-value: 3.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 226 PEGAARCYGRALRLLLTLPPPGPPERTVLHANLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKA 305
Cdd:COG4785   47 ALAAAALAAAALAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAA 126

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 119623992 306 TADLKKVLAIDPKNRAAQEELGKVVIQGKNQDAGLAQ 342
Cdd:COG4785  127 LEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIAD 163
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 200-319 1.14e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 53.27  E-value: 1.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 200 ELETSEKEALAreerARGTELFRAGNPEGAARCYGRALRLLLtlpppgppERTVLHANLAACQLLLGQPQLAAQSCDRVL 279
Cdd:COG4783   32 ELDPDNPEAFA----LLGEILLQLGDLDEAIVLLHEALELDP--------DEPEARLNLGLALLKAGDYDEALALLEKAL 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 119623992 280 EREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKN 319
Cdd:COG4783  100 KLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
220-321 1.59e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 51.71  E-value: 1.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 220 LFRAGNPEGAARCYGRALRLLLtlpppgppERTVLHANLAACQLLLGQPQlAAQSCDRVLEREPGHLKALYRRGVAQAAL 299
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDP--------DNADALNNLGLLLLEQGRYD-EAIALEKALKLDPNNAEALLNLAELLLEL 72

                         90       100
                 ....*....|....*....|..
gi 119623992 300 GNLEKATADLKKVLAIDPKNRA 321
Cdd:COG3063   73 GDYDEALAYLERALELDPSALR 94
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
216-324 3.24e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.86  E-value: 3.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 216 RGTELFRAGNPEGAARCYGRALRLLLtlpppgppERTVLHANLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVA 295
Cdd:COG0457   82 LGLALQALGRYEEALEDYDKALELDP--------DDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIA 153

                         90       100
                 ....*....|....*....|....*....
gi 119623992 296 QAALGNLEKATADLKKVLAIDPKNRAAQE 324
Cdd:COG0457  154 LEKLGRYEEALELLEKLEAAALAALLAAA 182
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 219-324 3.77e-08

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 51.15  E-value: 3.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 219 ELFRAGNPEGAARCYGRALRLLLTLPPPGPPertvlHANLAACQLLLGQPQLAAQSCDRVLEREPGHLK---ALYRRGVA 295
Cdd:COG1729    2 ALLKAGDYDEAIAAFKAFLKRYPNSPLAPDA-----LYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdALLKLGLS 76

                         90       100
                 ....*....|....*....|....*....
gi 119623992 296 QAALGNLEKATADLKKVLAIDPKNRAAQE 324
Cdd:COG1729   77 YLELGDYDKARATLEELIKKYPDSEAAKE 105
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 201-347 5.18e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.58  E-value: 5.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 201 LETSEKEALAREERARgtELFRAGNPEGAARCYGRALRLLLTLPPpgppertvLHANLAACQLLLGQPQLAAQSCDRVLE 280
Cdd:COG2956  137 LKLGPENAHAYCELAE--LYLEQGDYDEAIEALEKALKLDPDCAR--------ALLLLAELYLEQGDYEEAIAALERALE 206

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119623992 281 REPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNrAAQEELGKVVIQGKNQDAGLAQGLRKM 347
Cdd:COG2956  207 QDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSD-DLLLALADLLERKEGLEAALALLERQL 272
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 187-348 8.57e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 53.93  E-value: 8.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992  187 LTLASFTQGRDSWELETSE-KEALAREERA-----RGTELFRAGNPEGAARCYGRALRLlltlpppgppERTVLHANLAA 260
Cdd:TIGR02917  96 LARAYLLQGKFQQVLDELPgKTLLDDEGAAellalRGLAYLGLGQLELAQKSYEQALAI----------DPRSLYAKLGL 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992  261 CQLLLGQPQL--AAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKVVIQGKNQDA 338
Cdd:TIGR02917 166 AQLALAENRFdeARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEE 245

                         170
                  ....*....|..
gi 119623992  339 GL--AQGLRKMF 348
Cdd:TIGR02917 246 AEkhADALLKKA 257
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
261-338 1.03e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.40  E-value: 1.03e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119623992 261 CQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKAtADLKKVLAIDPKNRAAQEELGKVVI-QGKNQDA 338
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLeLGDYDEA 78
TPR_1 pfam00515
Tetratricopeptide repeat;
287-319 1.13e-06

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 44.33  E-value: 1.13e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 119623992  287 KALYRRGVAQAALGNLEKATADLKKVLAIDPKN 319
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 219-341 1.67e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.96  E-value: 1.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 219 ELFRA-GNPEGAARCYGRALRLLLtlpppgppERTVLHANLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQA 297
Cdd:COG2956   50 NLYRRrGEYDRAIRIHQKLLERDP--------DRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYE 121

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 119623992 298 ALGNLEKATADLKKVLAIDPKNRAAQEELGKVVIQGKNQDAGLA 341
Cdd:COG2956  122 QEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIE 165
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 254-342 1.88e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.57  E-value: 1.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 254 LHANLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKVVIQG 333
Cdd:COG2956   44 AHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQE 123


                 ....*....
gi 119623992 334 KNQDAGLAQ 342
Cdd:COG2956  124 GDWEKAIEV 132
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 271-341 4.80e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 45.38  E-value: 4.80e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119623992 271 AAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKVVIQGKNQDAGLA 341
Cdd:COG4235    2 AIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEE 72
TPR_19 pfam14559
Tetratricopeptide repeat;
266-329 1.75e-05

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 42.19  E-value: 1.75e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119623992  266 GQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKV 329
Cdd:pfam14559   2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALLAKL 65
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 287-319 2.04e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 40.89  E-value: 2.04e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 119623992   287 KALYRRGVAQAALGNLEKATADLKKVLAIDPKN 319
Cdd:smart00028   2 EALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
279-338 2.54e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.00  E-value: 2.54e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119623992 279 LEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKV-VIQGKNQDA 338
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAyLRLGRYEEA 61
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 287-318 2.23e-04

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 37.89  E-value: 2.23e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 119623992  287 KALYRRGVAQAALGNLEKATADLKKVLAIDPK 318
Cdd:pfam07719   2 EALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 262-317 2.31e-04

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 42.62  E-value: 2.31e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 119623992 262 QLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDP 317
Cdd:cd24142   10 LLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDP 65
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 201-326 2.47e-04

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 43.05  E-value: 2.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992  201 LETSEKEALAREERARGTELFRAGNPEGAARCYGRALRLLltlpppgppERTVLHANLAACQLLLGQPQLAAQSCDRVLE 280
Cdd:TIGR00990 118 LSEEERKKYAAKLKEKGNKAYRNKDFNKAIKLYSKAIECK---------PDPVYYSNRAACHNALGDWEKVVEDTTAALE 188

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 119623992  281 REPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEEL 326
Cdd:TIGR00990 189 LDPDYSKALNRRANAYDGLGKYADALLDLTASCIIDGFRNEQSAQA 234
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 263-338 3.54e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 39.59  E-value: 3.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 263 LLLGQPQLAAQSCDRVLEREPGHL---KALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQE---ELGKV-VIQGKN 335
Cdd:COG1729    4 LKAGDYDEAIAAFKAFLKRYPNSPlapDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDallKLGLSyLELGDY 83


                 ...
gi 119623992 336 QDA 338
Cdd:COG1729   84 DKA 86
TPR_9 pfam13371
Tetratricopeptide repeat;
266-322 1.13e-03

Tetratricopeptide repeat;


Pssm-ID: 463860 [Multi-domain]  Cd Length: 73  Bit Score: 37.20  E-value: 1.13e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 119623992  266 GQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAA 322
Cdd:pfam13371   9 EDWERALAVVERLLLLAPDDPEERRDRGLLYAQLGCFQAALEDLEAYLELAPDAPDA 65
PRK09782 PRK09782
bacteriophage N4 receptor, outer membrane subunit; Provisional
 223-327 1.73e-03

bacteriophage N4 receptor, outer membrane subunit; Provisional


Pssm-ID: 236624 [Multi-domain]  Cd Length: 987  Bit Score: 40.28  E-value: 1.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992 223 AGNPEGAARCYGRALRLLLtlpppgppERTVLHANLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAAlGNL 302
Cdd:PRK09782 555 AGNGAARDRWLQQAEQRGL--------GDNALYWWLHAQRYIPGQPELALNDLTRSLNIAPSANAYVARATIYRQR-HNV 625

                         90       100
                 ....*....|....*....|....*
gi 119623992 303 EKATADLKKVLAIDPKNRAAQEELG 327
Cdd:PRK09782 626 PAAVSDLRAALELEPNNSNYQAALG 650
TPR_8 pfam13181
Tetratricopeptide repeat;
286-318 2.88e-03

Tetratricopeptide repeat;


Pssm-ID: 404131 [Multi-domain]  Cd Length: 33  Bit Score: 34.68  E-value: 2.88e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 119623992  286 LKALYRRGVAQAALGNLEKATADLKKVLAIDPK 318
Cdd:pfam13181   1 AEAYYNLGLIYLKLGDYEEAKEYYEKALELDPD 33
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 220-292 5.01e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 38.82  E-value: 5.01e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119623992 220 LFRAGNPEGAARCYGRALRLLLtlpppgppERTVLHANLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRR 292
Cdd:COG3914  156 LRRLGRLEEAIAALRRALELDP--------DNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 265-319 5.31e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 35.00  E-value: 5.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 119623992  265 LGQPQLAAQSCDRVLERE---PGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKN 319
Cdd:pfam13432  10 AGDYDDAAAALEAALARFpesPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPGD 67
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 258-340 6.18e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.53  E-value: 6.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992  258 LAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKVVIQGKNQD 337
Cdd:TIGR02917 607 LGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTE 686


                  ...
gi 119623992  338 AGL 340
Cdd:TIGR02917 687 SAK 689
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 258-327 7.17e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.53  E-value: 7.17e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992  258 LAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELG 327
Cdd:TIGR02917 335 LASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLG 404
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 216-339 8.17e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.14  E-value: 8.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119623992  216 RGTELFRAGNPEGAARCYGRALRLLLTLPPPgppertvlHANLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVA 295
Cdd:TIGR02917 199 KGDLLLSLGNIELALAAYRKAIALRPNNIAV--------LLALATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALV 270

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 119623992  296 QAALGNLEKATADLKKVLAIDPKNRAAQEELGKVVIQ-GKNQDAG 339
Cdd:TIGR02917 271 DFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQlGNLEQAY 315
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 277-342 9.14e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.14  E-value: 9.14e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119623992  277 RVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKVVIQGKNQDAGLAQ 342
Cdd:TIGR02917 286 DALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIAT 351
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 255-318 9.47e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.14  E-value: 9.47e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119623992  255 HANLAACQLLLGQPQLAAQSCDRVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPK 318
Cdd:TIGR02917 196 LLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPN 259
TPR_11 pfam13414
TPR repeat;
298-329 9.80e-03

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 33.60  E-value: 9.80e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 119623992  298 ALGNLEKATADLKKVLAIDPKNRAAQEELGKV 329
Cdd:pfam13414   6 EQGKYEEAIEAYKKALKLDPDNPEAYYNLGLA 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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