NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|119621042|gb|EAX00637|]
View 

cell growth regulator with EF-hand domain 1, isoform CRA_c [Homo sapiens]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 12144783)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

CATH:  1.10.238.10
Gene Ontology:  GO:0005509
PubMed:  2479149|10191494
SCOP:  3001983

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
173-292 7.03e-05

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 44.22  E-value: 7.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621042   173 AKSPLRQETQEAPGPREEAKG--------QVEARRESLDPVQEPGGQAEADGDVPGPRGEAEGQAEAKGDAPGPRGEAGG 244
Cdd:TIGR00927  657 GENGEESGGEAEQEGETETKGenesegeiPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGE 736
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 119621042   245 QAEAEGDAPGPRGEAGGQAEARENGEEAKELPGETLESKNTQNDFEVH 292
Cdd:TIGR00927  737 EGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQ 784
EF-hand_7 pfam13499
EF-hand domain pair;
71-135 1.59e-04

EF-hand domain pair;


:

Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 39.16  E-value: 1.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119621042   71 EQVLLYLFALHDYDQSGQLDGLELLSMLTAAlapGAANSPTTNPVilivDKVLETQDLNGDGLMT 135
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKL---EEGEPLSDEEV----EELFKEFDLDKDGRIS 58
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
173-292 7.03e-05

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 44.22  E-value: 7.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621042   173 AKSPLRQETQEAPGPREEAKG--------QVEARRESLDPVQEPGGQAEADGDVPGPRGEAEGQAEAKGDAPGPRGEAGG 244
Cdd:TIGR00927  657 GENGEESGGEAEQEGETETKGenesegeiPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGE 736
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 119621042   245 QAEAEGDAPGPRGEAGGQAEARENGEEAKELPGETLESKNTQNDFEVH 292
Cdd:TIGR00927  737 EGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQ 784
EF-hand_7 pfam13499
EF-hand domain pair;
71-135 1.59e-04

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 39.16  E-value: 1.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119621042   71 EQVLLYLFALHDYDQSGQLDGLELLSMLTAAlapGAANSPTTNPVilivDKVLETQDLNGDGLMT 135
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKL---EEGEPLSDEEV----EELFKEFDLDKDGRIS 58
PHA03169 PHA03169
hypothetical protein; Provisional
180-292 8.72e-04

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 40.72  E-value: 8.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621042 180 ETQEAPGPREEAKGQVEARRESLDPVQEPGGQAEA-----DGDVPGPRGEAEGQAEAKGDAPGPRGEAGGQAEAEGDAPG 254
Cdd:PHA03169 133 SHSPPPSPPSHPGPHEPAPPESHNPSPNQQPSSFLqpsheDSPEEPEPPTSEPEPDSPGPPQSETPTSSPPPQSPPDEPG 212
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 119621042 255 PRGEAGGQAEARENGEEAKELPGETLESKNTQNDFEVH 292
Cdd:PHA03169 213 EPQSPTPQQAPSPNTQQAVEHEDEPTEPEREGPPFPGH 250
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
173-292 7.03e-05

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 44.22  E-value: 7.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621042   173 AKSPLRQETQEAPGPREEAKG--------QVEARRESLDPVQEPGGQAEADGDVPGPRGEAEGQAEAKGDAPGPRGEAGG 244
Cdd:TIGR00927  657 GENGEESGGEAEQEGETETKGenesegeiPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGE 736
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 119621042   245 QAEAEGDAPGPRGEAGGQAEARENGEEAKELPGETLESKNTQNDFEVH 292
Cdd:TIGR00927  737 EGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQ 784
EF-hand_7 pfam13499
EF-hand domain pair;
71-135 1.59e-04

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 39.16  E-value: 1.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119621042   71 EQVLLYLFALHDYDQSGQLDGLELLSMLTAAlapGAANSPTTNPVilivDKVLETQDLNGDGLMT 135
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKL---EEGEPLSDEEV----EELFKEFDLDKDGRIS 58
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
150-283 1.63e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 43.06  E-value: 1.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621042   150 VEPGEPLAPSPQEPQAVGRQSLLAKSPLRQETQEAPGPREEAKGQVEARR-----ESLDPVQEPGGQAEADGDVPGPRGE 224
Cdd:TIGR00927  654 EAEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEadhkgETEAEEVEHEGETEAEGTEDEGEIE 733
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 119621042   225 AEGQAEAKGDAPGPRGEAGGQAEAEGDAPGPRGEAGGQAEARENGEEAKELPGETLESK 283
Cdd:TIGR00927  734 TGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMK 792
PHA03169 PHA03169
hypothetical protein; Provisional
180-292 8.72e-04

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 40.72  E-value: 8.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621042 180 ETQEAPGPREEAKGQVEARRESLDPVQEPGGQAEA-----DGDVPGPRGEAEGQAEAKGDAPGPRGEAGGQAEAEGDAPG 254
Cdd:PHA03169 133 SHSPPPSPPSHPGPHEPAPPESHNPSPNQQPSSFLqpsheDSPEEPEPPTSEPEPDSPGPPQSETPTSSPPPQSPPDEPG 212
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 119621042 255 PRGEAGGQAEARENGEEAKELPGETLESKNTQNDFEVH 292
Cdd:PHA03169 213 EPQSPTPQQAPSPNTQQAVEHEDEPTEPEREGPPFPGH 250
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
159-300 2.93e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 39.21  E-value: 2.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621042   159 SPQEPQAVGRQSLLAKSPLRQETQEAPGPREEAKGQVEARRESLDPVQEPGGQAEADGDVPGPRGEAEGQA----EAKGD 234
Cdd:TIGR00927  681 SEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGkhevETEGD 760
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119621042   235 APGPRGEAGGQAEAEGDAPGPRGEAGGQAEARENGEEAKELPGETLESKNTQNDFEVHIVQVENDE 300
Cdd:TIGR00927  761 RKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDT 826
PHA03169 PHA03169
hypothetical protein; Provisional
148-278 2.97e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 38.80  E-value: 2.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621042 148 RHVEPGEPLAPSPQEPQAVG-RQSLLAKSPLRQETQEAPGPREEAKGQVEAR---------RESLD-PVQEPGGQAEADG 216
Cdd:PHA03169  36 RRGTAARAAKPAPPAPTTSGpQVRAVAEQGHRQTESDTETAEESRHGEKEERgqggpsgsgSESVGsPTPSPSGSAEELA 115
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119621042 217 DVPGPRGEAEGQAEA---KGDAPGPRGEAGGQAEAEGDAPGPRGEAGGQAEARENGEEAKELPGE 278
Cdd:PHA03169 116 SGLSPENTSGSSPESpasHSPPPSPPSHPGPHEPAPPESHNPSPNQQPSSFLQPSHEDSPEEPEP 180
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
180-274 5.61e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 38.44  E-value: 5.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119621042   180 ETQEAPGPREEAKGQVEARRESLDPVQEPGGQAEADGDVPGPRGEAEGQAEAKGDAPGPRGEAGGQAEAEGDAPGPRGEA 259
Cdd:TIGR00927  753 HEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDET 832
                           90
                   ....*....|....*
gi 119621042   260 GGQAEARENGEEAKE 274
Cdd:TIGR00927  833 GEQELNAENQGEAKQ 847
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH