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Conserved domains on  [gi|119618746|gb|EAW98340|]
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density-regulated protein, isoform CRA_c, partial [Homo sapiens]

Protein Classification

SUI1 family translation initiation factor( domain architecture ID 960)

SUI1 family translation initiation factor is involved in the regulation of translation initiation, recognizing the start codon on mRNA by the ribosome and interacting with other components of the translation initiation complex to facilitate the assembly of the translation machinery.

Gene Ontology:  GO:0003723|GO:0003743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
eIF1_SUI1_like super family cl00229
Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic ...
 1-112 3.19e-47

Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown. The function of non-eukaryotic family members is also unclear.


The actual alignment was detected with superfamily member TIGR01159:

Pssm-ID: 469673  Cd Length: 173  Bit Score: 149.26  E-value: 3.19e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119618746    1 MPDVAKCRQWLEKNFPNEFAKLTVENSPKQEA---GISEGQGTAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRA 77
Cdd:TIGR01159  20 SGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAeavTIGEAQEEKGEKDLLGIQKAQEAREGGKKKKKLPQKVTIKREPRT 99

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 119618746   78 KKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASV 112
Cdd:TIGR01159 100 KRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSV 134
 
Name Accession Description Interval E-value
DRP1 TIGR01159
density-regulated protein DRP1; This protein family shows weak but suggestive similarity to ...
 1-112 3.19e-47

density-regulated protein DRP1; This protein family shows weak but suggestive similarity to translation initiation factor SUI1 and its prokaryotic homologs.


Pssm-ID: 273472  Cd Length: 173  Bit Score: 149.26  E-value: 3.19e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119618746    1 MPDVAKCRQWLEKNFPNEFAKLTVENSPKQEA---GISEGQGTAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRA 77
Cdd:TIGR01159  20 SGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAeavTIGEAQEEKGEKDLLGIQKAQEAREGGKKKKKLPQKVTIKREPRT 99

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 119618746   78 KKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASV 112
Cdd:TIGR01159 100 KRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSV 134
DENR_C cd11607
C-terminal domain of DENR and related proteins; DENR (density regulated protein), together ...
 67-112 4.55e-21

C-terminal domain of DENR and related proteins; DENR (density regulated protein), together with MCT-1 (multiple copies T cell malignancies), has been shown to have similar function as eIF2D translation initiation factor (also known as ligatin), which is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211320  Cd Length: 86  Bit Score: 79.91  E-value: 4.55e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 119618746  67 QKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASV 112
Cdd:cd11607    1 SKVTIKRISRNKRKFVTTVTGLETFGIDLKKAAKLFAKKFACGASV 46
SUI1 pfam01253
Translation initiation factor SUI1;
66-112 7.20e-09

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 48.58  E-value: 7.20e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 119618746   66 PQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASV 112
Cdd:pfam01253   1 QPKIHIRVEQRGGRKTVTTVSGLEPFGIDLKKLAKELKKKFACGGTV 47
 
Name Accession Description Interval E-value
DRP1 TIGR01159
density-regulated protein DRP1; This protein family shows weak but suggestive similarity to ...
 1-112 3.19e-47

density-regulated protein DRP1; This protein family shows weak but suggestive similarity to translation initiation factor SUI1 and its prokaryotic homologs.


Pssm-ID: 273472  Cd Length: 173  Bit Score: 149.26  E-value: 3.19e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119618746    1 MPDVAKCRQWLEKNFPNEFAKLTVENSPKQEA---GISEGQGTAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRA 77
Cdd:TIGR01159  20 SGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAeavTIGEAQEEKGEKDLLGIQKAQEAREGGKKKKKLPQKVTIKREPRT 99

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 119618746   78 KKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASV 112
Cdd:TIGR01159 100 KRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSV 134
DENR_C cd11607
C-terminal domain of DENR and related proteins; DENR (density regulated protein), together ...
 67-112 4.55e-21

C-terminal domain of DENR and related proteins; DENR (density regulated protein), together with MCT-1 (multiple copies T cell malignancies), has been shown to have similar function as eIF2D translation initiation factor (also known as ligatin), which is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211320  Cd Length: 86  Bit Score: 79.91  E-value: 4.55e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 119618746  67 QKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASV 112
Cdd:cd11607    1 SKVTIKRISRNKRKFVTTVTGLETFGIDLKKAAKLFAKKFACGASV 46
eIF1_SUI1_like cd00474
Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic ...
 68-112 1.57e-11

Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown. The function of non-eukaryotic family members is also unclear.


Pssm-ID: 211317  Cd Length: 78  Bit Score: 55.51  E-value: 1.57e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 119618746  68 KVTIAKIPRAKKKYVTRVCGLATFeIDLKEAQRFFAQKFSCGASV 112
Cdd:cd00474    1 KIHIKVEQRSGGKKVTKVEGLPAY-IDLRKLADELKKKLGCGGSV 44
SUI1 pfam01253
Translation initiation factor SUI1;
66-112 7.20e-09

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 48.58  E-value: 7.20e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 119618746   66 PQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASV 112
Cdd:pfam01253   1 QPKIHIRVEQRGGRKTVTTVSGLEPFGIDLKKLAKELKKKFACGGTV 47
eIF2D_C cd11608
C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also ...
 66-112 2.55e-03

C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also known as ligatin) is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211321  Cd Length: 85  Bit Score: 34.08  E-value: 2.55e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 119618746  66 PQKVTIAKipRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASV 112
Cdd:cd11608    1 PIDITTER--RQGNKKVTLISGLESFGIDPEEFAKELQKKCAASTSV 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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