NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|119616466|gb|EAW96060|]
View 

elongation factor, RNA polymerase II, 2 [Homo sapiens]

Protein Classification

ELL and Occludin_ELL domain-containing protein( domain architecture ID 12105631)

ELL and Occludin_ELL domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
ELL pfam10390
RNA polymerase II elongation factor ELL; ELL is a family of RNA polymerase II elongation ...
11-291 4.78e-173

RNA polymerase II elongation factor ELL; ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity. by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF. Some members carry an Occludin domain pfam07303 just downstream. There is no S. cerevisiae member.


:

Pssm-ID: 463068  Cd Length: 281  Bit Score: 493.34  E-value: 4.78e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616466   11 EEQRYGLSCGRLGQD-NITVLHVKLTETAIRALETYQSHKNLIPFRPSIQFQGLHGLVKIPKNDPLNEVHNFNFYLSNVG 89
Cdd:pfam10390   1 EEGNYGLSCGRVSDDsNKSVFHVKLTDSALRALESYQNAKLSLSSQPTIQFQGNQGRIKIPRSDNGSEVRTFTFYLSNVG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616466   90 KDNPQGSFDCIQQtFSSSGASQLNCLGFIQDKITVCATNDSYQMTRERMTQAEEESRNRSTKVIKPGGPYVGKRVQIRKA 169
Cdd:pfam10390  81 KDNPQGSFDCIQQ-YVSSGSEQLECLGSIQDKITVCATDDSYQKTRERMAQAEEETRSRSAIVIKPGGTYIGKKVQIRKP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616466  170 PQAVSDTVPERKRSTPMNPANTIRKTHSSSTISQRPYRDRVIHLLALKAYKKPELLARLQKDGVNQKDKNSLGAILQQVA 249
Cdd:pfam10390 160 APAASDAAPSRKRSSPSNPASTIRKTNSSSDVSQRPLRERVIHLLALKPYKKPELLLRLQKDGLSQKDKNSLGSILQEVA 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 119616466  250 NLNSKDLSYTLKDYVFKELQRDWPGYSEIDRRSLESVLSRKL 291
Cdd:pfam10390 240 NLNPKDNTYTLKDHLYKEVQKDWPGYSEGDRQLLKRILVRKL 281
Occludin_ELL pfam07303
Occludin homology domain; This domain represents a conserved region approximately 100 residues ...
532-633 1.44e-47

Occludin homology domain; This domain represents a conserved region approximately 100 residues long within eukaryotic occludin proteins and the RNA polymerase II elongation factor ELL. Occludin is an integral membrane protein that localizes to tight junctions, while ELL is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. This shared domain is thought to mediate protein interactions.


:

Pssm-ID: 462140 [Multi-domain]  Cd Length: 101  Bit Score: 162.31  E-value: 1.44e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616466  532 YIAIVSYEQRQNYKDDFNAEYDEYRALHARMETVARRFIKLDAQRKRLSPGSKEYQNVHEEVLQEYQKIKQsSPNYHEEK 611
Cdd:pfam07303   1 YPPITSDEQRQRYKQEFNAEYDEYKELHAELDAVSRKFQKLDRELKSLPEGSKEYQDIAEEILQEYKKKKK-DPEYQEKK 79
                          90       100
                  ....*....|....*....|..
gi 119616466  612 YRCEYLHNKLAHIKRLIGEFDQ 633
Cdd:pfam07303  80 KRCEYLHNKLSHIKRLILEYDQ 101
 
Name Accession Description Interval E-value
ELL pfam10390
RNA polymerase II elongation factor ELL; ELL is a family of RNA polymerase II elongation ...
11-291 4.78e-173

RNA polymerase II elongation factor ELL; ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity. by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF. Some members carry an Occludin domain pfam07303 just downstream. There is no S. cerevisiae member.


Pssm-ID: 463068  Cd Length: 281  Bit Score: 493.34  E-value: 4.78e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616466   11 EEQRYGLSCGRLGQD-NITVLHVKLTETAIRALETYQSHKNLIPFRPSIQFQGLHGLVKIPKNDPLNEVHNFNFYLSNVG 89
Cdd:pfam10390   1 EEGNYGLSCGRVSDDsNKSVFHVKLTDSALRALESYQNAKLSLSSQPTIQFQGNQGRIKIPRSDNGSEVRTFTFYLSNVG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616466   90 KDNPQGSFDCIQQtFSSSGASQLNCLGFIQDKITVCATNDSYQMTRERMTQAEEESRNRSTKVIKPGGPYVGKRVQIRKA 169
Cdd:pfam10390  81 KDNPQGSFDCIQQ-YVSSGSEQLECLGSIQDKITVCATDDSYQKTRERMAQAEEETRSRSAIVIKPGGTYIGKKVQIRKP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616466  170 PQAVSDTVPERKRSTPMNPANTIRKTHSSSTISQRPYRDRVIHLLALKAYKKPELLARLQKDGVNQKDKNSLGAILQQVA 249
Cdd:pfam10390 160 APAASDAAPSRKRSSPSNPASTIRKTNSSSDVSQRPLRERVIHLLALKPYKKPELLLRLQKDGLSQKDKNSLGSILQEVA 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 119616466  250 NLNSKDLSYTLKDYVFKELQRDWPGYSEIDRRSLESVLSRKL 291
Cdd:pfam10390 240 NLNPKDNTYTLKDHLYKEVQKDWPGYSEGDRQLLKRILVRKL 281
Occludin_ELL pfam07303
Occludin homology domain; This domain represents a conserved region approximately 100 residues ...
532-633 1.44e-47

Occludin homology domain; This domain represents a conserved region approximately 100 residues long within eukaryotic occludin proteins and the RNA polymerase II elongation factor ELL. Occludin is an integral membrane protein that localizes to tight junctions, while ELL is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. This shared domain is thought to mediate protein interactions.


Pssm-ID: 462140 [Multi-domain]  Cd Length: 101  Bit Score: 162.31  E-value: 1.44e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616466  532 YIAIVSYEQRQNYKDDFNAEYDEYRALHARMETVARRFIKLDAQRKRLSPGSKEYQNVHEEVLQEYQKIKQsSPNYHEEK 611
Cdd:pfam07303   1 YPPITSDEQRQRYKQEFNAEYDEYKELHAELDAVSRKFQKLDRELKSLPEGSKEYQDIAEEILQEYKKKKK-DPEYQEKK 79
                          90       100
                  ....*....|....*....|..
gi 119616466  612 YRCEYLHNKLAHIKRLIGEFDQ 633
Cdd:pfam07303  80 KRCEYLHNKLSHIKRLILEYDQ 101
 
Name Accession Description Interval E-value
ELL pfam10390
RNA polymerase II elongation factor ELL; ELL is a family of RNA polymerase II elongation ...
11-291 4.78e-173

RNA polymerase II elongation factor ELL; ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity. by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF. Some members carry an Occludin domain pfam07303 just downstream. There is no S. cerevisiae member.


Pssm-ID: 463068  Cd Length: 281  Bit Score: 493.34  E-value: 4.78e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616466   11 EEQRYGLSCGRLGQD-NITVLHVKLTETAIRALETYQSHKNLIPFRPSIQFQGLHGLVKIPKNDPLNEVHNFNFYLSNVG 89
Cdd:pfam10390   1 EEGNYGLSCGRVSDDsNKSVFHVKLTDSALRALESYQNAKLSLSSQPTIQFQGNQGRIKIPRSDNGSEVRTFTFYLSNVG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616466   90 KDNPQGSFDCIQQtFSSSGASQLNCLGFIQDKITVCATNDSYQMTRERMTQAEEESRNRSTKVIKPGGPYVGKRVQIRKA 169
Cdd:pfam10390  81 KDNPQGSFDCIQQ-YVSSGSEQLECLGSIQDKITVCATDDSYQKTRERMAQAEEETRSRSAIVIKPGGTYIGKKVQIRKP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616466  170 PQAVSDTVPERKRSTPMNPANTIRKTHSSSTISQRPYRDRVIHLLALKAYKKPELLARLQKDGVNQKDKNSLGAILQQVA 249
Cdd:pfam10390 160 APAASDAAPSRKRSSPSNPASTIRKTNSSSDVSQRPLRERVIHLLALKPYKKPELLLRLQKDGLSQKDKNSLGSILQEVA 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 119616466  250 NLNSKDLSYTLKDYVFKELQRDWPGYSEIDRRSLESVLSRKL 291
Cdd:pfam10390 240 NLNPKDNTYTLKDHLYKEVQKDWPGYSEGDRQLLKRILVRKL 281
Occludin_ELL pfam07303
Occludin homology domain; This domain represents a conserved region approximately 100 residues ...
532-633 1.44e-47

Occludin homology domain; This domain represents a conserved region approximately 100 residues long within eukaryotic occludin proteins and the RNA polymerase II elongation factor ELL. Occludin is an integral membrane protein that localizes to tight junctions, while ELL is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. This shared domain is thought to mediate protein interactions.


Pssm-ID: 462140 [Multi-domain]  Cd Length: 101  Bit Score: 162.31  E-value: 1.44e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616466  532 YIAIVSYEQRQNYKDDFNAEYDEYRALHARMETVARRFIKLDAQRKRLSPGSKEYQNVHEEVLQEYQKIKQsSPNYHEEK 611
Cdd:pfam07303   1 YPPITSDEQRQRYKQEFNAEYDEYKELHAELDAVSRKFQKLDRELKSLPEGSKEYQDIAEEILQEYKKKKK-DPEYQEKK 79
                          90       100
                  ....*....|....*....|..
gi 119616466  612 YRCEYLHNKLAHIKRLIGEFDQ 633
Cdd:pfam07303  80 KRCEYLHNKLSHIKRLILEYDQ 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH