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Conserved domains on  [gi|119616238|gb|EAW95832|]
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betaine-homocysteine methyltransferase, isoform CRA_b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
S-methyl_trans super family cl47750
Homocysteine S-methyltransferase; This is a family of related homocysteine ...
 23-192 2.50e-16

Homocysteine S-methyltransferase; This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases also known EC:2.1.1.13; Betaine--homocysteine S-methyltransferase (vitamin B12 dependent), EC:2.1.1.5; and Homocysteine S-methyltransferase, EC:2.1.1.10,.


The actual alignment was detected with superfamily member pfam02574:

Pssm-ID: 460598 [Multi-domain]  Cd Length: 268  Bit Score: 76.81  E-value: 2.50e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616238   23 VIGDGGFVFALEKRGYVKAGP-WTPEAAVeHPEAVRQLHREFLRAGSNVMQTFTFYASEDKL------ENRGASII---- 91
Cdd:pfam02574   1 LILDGGMGTELQRRGLDLTEPlWSNELLT-RPEIIREIHRDYLEAGADIIETNTYQASPIKLaegleeEEAVYELNraav 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616238   92 -------------------GVNCHFDPTISLKTVK---------LMKEG------------LEA---ARLKA-------- 120
Cdd:pfam02574  80 rlareaadeyfvagsigpyGATLSDGYGLSFDELVdfhreqleaLLDGGvdlllfetipdlLEAkaaLELLAeepdlpvw 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616238  121 ---------HLMS-QPLA--------YHTPD-----CNK--------QGFIDLPEFPFGLEP-RVATRWDIQ-----KYA 163
Cdd:pfam02574 160 isftiedgtRLRSgTTLEaavaallhATGPLavgvnCALpeemlpllKELAKDAPTPVSVYPnSTGEVYDLTpeewaEYA 239

                         250       260
                  ....*....|....*....|....*....
gi 119616238  164 REAYNLGVRYIGGCCGFEPYHIRAIAEEL 192
Cdd:pfam02574 240 EGWLEAGANIIGGCCGTTPEHIRAIAEAL 268
 
Name Accession Description Interval E-value
S-methyl_trans pfam02574
Homocysteine S-methyltransferase; This is a family of related homocysteine ...
 23-192 2.50e-16

Homocysteine S-methyltransferase; This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases also known EC:2.1.1.13; Betaine--homocysteine S-methyltransferase (vitamin B12 dependent), EC:2.1.1.5; and Homocysteine S-methyltransferase, EC:2.1.1.10,.


Pssm-ID: 460598 [Multi-domain]  Cd Length: 268  Bit Score: 76.81  E-value: 2.50e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616238   23 VIGDGGFVFALEKRGYVKAGP-WTPEAAVeHPEAVRQLHREFLRAGSNVMQTFTFYASEDKL------ENRGASII---- 91
Cdd:pfam02574   1 LILDGGMGTELQRRGLDLTEPlWSNELLT-RPEIIREIHRDYLEAGADIIETNTYQASPIKLaegleeEEAVYELNraav 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616238   92 -------------------GVNCHFDPTISLKTVK---------LMKEG------------LEA---ARLKA-------- 120
Cdd:pfam02574  80 rlareaadeyfvagsigpyGATLSDGYGLSFDELVdfhreqleaLLDGGvdlllfetipdlLEAkaaLELLAeepdlpvw 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616238  121 ---------HLMS-QPLA--------YHTPD-----CNK--------QGFIDLPEFPFGLEP-RVATRWDIQ-----KYA 163
Cdd:pfam02574 160 isftiedgtRLRSgTTLEaavaallhATGPLavgvnCALpeemlpllKELAKDAPTPVSVYPnSTGEVYDLTpeewaEYA 239

                         250       260
                  ....*....|....*....|....*....
gi 119616238  164 REAYNLGVRYIGGCCGFEPYHIRAIAEEL 192
Cdd:pfam02574 240 EGWLEAGANIIGGCCGTTPEHIRAIAEAL 268
PRK08645 PRK08645
bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; ...
 81-205 1.09e-10

bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed


Pssm-ID: 236321 [Multi-domain]  Cd Length: 612  Bit Score: 61.78  E-value: 1.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616238  81 DKLENRGASIIGVNCHFDPTISLKTVKLMkegleAARLKAHLMSQPLA-YhtPDC--NKQGFIDLPEFpFGleprvatrw 157
Cdd:PRK08645 191 KELVAAGADVVGLNCGLGPYHMLEALERI-----PIPENAPLSAYPNAgL--PEYvdGRYVYSANPEY-FA--------- 253

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 119616238 158 diqKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPergfLPPASEK 205
Cdd:PRK08645 254 ---EYALEFVEQGVRLIGGCCGTTPEHIRAMARALKG----LKPVTEK 294
MHT1 COG2040
Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and ...
 17-89 1.40e-08

Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism];


Pssm-ID: 441643 [Multi-domain]  Cd Length: 301  Bit Score: 54.82  E-value: 1.40e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119616238  17 LNAGEIVIGDGGFVFALEKRGYVKAGP-WTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGAS 89
Cdd:COG2040    8 LLMGRILLLDGGMGTELERRGGDLLDPlWSAFALLEAPELVRAVHRDYFAAGADVITTNSYQASPDGLAELGYS 81
metH TIGR02082
5-methyltetrahydrofolate--homocysteine methyltransferase; This family represents ...
 76-203 4.45e-06

5-methyltetrahydrofolate--homocysteine methyltransferase; This family represents 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13), one of at least three different enzymes able to convert homocysteine to methionine by transferring a methyl group on to the sulfur atom. It is also called the vitamin B12(or cobalamine)-dependent methionine synthase. Other methionine synthases include 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (MetE, EC 2.1.1.14, the cobalamin-independent methionine synthase) and betaine-homocysteine methyltransferase. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 273959 [Multi-domain]  Cd Length: 1181  Bit Score: 47.85  E-value: 4.45e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616238    76 FYASedkLENRGASIIGVNCHFDPtislktvKLMKEGLEaaRLKAHlMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVAt 155
Cdd:TIGR02082  218 FLTS---LEHAGIDMIGLNCALGP-------DEMRPHLK--HLSEH-AEAYVSCHPNAGLPNAFGEYDLTPDELAKALA- 283

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 119616238   156 rwdiqKYAREaynLGVRYIGGCCGFEPYHIRAIAEELA----PERGFLPPAS 203
Cdd:TIGR02082  284 -----DFAAE---GGLNIVGGCCGTTPDHIRAIAEAVKnikpRQRPVLYEPS 327
 
Name Accession Description Interval E-value
S-methyl_trans pfam02574
Homocysteine S-methyltransferase; This is a family of related homocysteine ...
 23-192 2.50e-16

Homocysteine S-methyltransferase; This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases also known EC:2.1.1.13; Betaine--homocysteine S-methyltransferase (vitamin B12 dependent), EC:2.1.1.5; and Homocysteine S-methyltransferase, EC:2.1.1.10,.


Pssm-ID: 460598 [Multi-domain]  Cd Length: 268  Bit Score: 76.81  E-value: 2.50e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616238   23 VIGDGGFVFALEKRGYVKAGP-WTPEAAVeHPEAVRQLHREFLRAGSNVMQTFTFYASEDKL------ENRGASII---- 91
Cdd:pfam02574   1 LILDGGMGTELQRRGLDLTEPlWSNELLT-RPEIIREIHRDYLEAGADIIETNTYQASPIKLaegleeEEAVYELNraav 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616238   92 -------------------GVNCHFDPTISLKTVK---------LMKEG------------LEA---ARLKA-------- 120
Cdd:pfam02574  80 rlareaadeyfvagsigpyGATLSDGYGLSFDELVdfhreqleaLLDGGvdlllfetipdlLEAkaaLELLAeepdlpvw 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616238  121 ---------HLMS-QPLA--------YHTPD-----CNK--------QGFIDLPEFPFGLEP-RVATRWDIQ-----KYA 163
Cdd:pfam02574 160 isftiedgtRLRSgTTLEaavaallhATGPLavgvnCALpeemlpllKELAKDAPTPVSVYPnSTGEVYDLTpeewaEYA 239

                         250       260
                  ....*....|....*....|....*....
gi 119616238  164 REAYNLGVRYIGGCCGFEPYHIRAIAEEL 192
Cdd:pfam02574 240 EGWLEAGANIIGGCCGTTPEHIRAIAEAL 268
PRK08645 PRK08645
bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; ...
 81-205 1.09e-10

bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed


Pssm-ID: 236321 [Multi-domain]  Cd Length: 612  Bit Score: 61.78  E-value: 1.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616238  81 DKLENRGASIIGVNCHFDPTISLKTVKLMkegleAARLKAHLMSQPLA-YhtPDC--NKQGFIDLPEFpFGleprvatrw 157
Cdd:PRK08645 191 KELVAAGADVVGLNCGLGPYHMLEALERI-----PIPENAPLSAYPNAgL--PEYvdGRYVYSANPEY-FA--------- 253

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 119616238 158 diqKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPergfLPPASEK 205
Cdd:PRK08645 254 ---EYALEFVEQGVRLIGGCCGTTPEHIRAMARALKG----LKPVTEK 294
MHT1 COG2040
Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and ...
 17-89 1.40e-08

Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism];


Pssm-ID: 441643 [Multi-domain]  Cd Length: 301  Bit Score: 54.82  E-value: 1.40e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119616238  17 LNAGEIVIGDGGFVFALEKRGYVKAGP-WTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGAS 89
Cdd:COG2040    8 LLMGRILLLDGGMGTELERRGGDLLDPlWSAFALLEAPELVRAVHRDYFAAGADVITTNSYQASPDGLAELGYS 81
mmuM PRK09485
homocysteine methyltransferase; Provisional
 13-194 1.86e-07

homocysteine methyltransferase; Provisional


Pssm-ID: 181899 [Multi-domain]  Cd Length: 304  Bit Score: 51.40  E-value: 1.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616238  13 ILERLNAGEIVIGDGGFVFALEKRGYVKAGP-WTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGASIi 91
Cdd:PRK09485   4 FKELLAQGPVLILDGALATELEARGCDLNDSlWSAKVLLENPELIYQVHLDYFRAGADCAITASYQATFQGFAARGLSE- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616238  92 gvnchfDPTISL--KTVKLMKEGLEAArLKAHLM--------------------------SQPLAYHTP----------D 133
Cdd:PRK09485  83 ------AEAEELirRSVELAKEARDEF-WAEKPLvagsvgpygayladgseyrgdyglseEELQDFHRPriealaeagaD 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616238 134 C----------NKQGFIDL--PEFP-------FGLE---------------------------------PRVAT------ 155
Cdd:PRK09485 156 LlacetipnldEAEALVELlkEEFPgvpawlsFTLRdgthisdgtplaeaaallaaspqvvavgvnctaPELVTaaiaal 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119616238 156 -----------------------RW-------DIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAP 194
Cdd:PRK09485 236 ravtdkplvvypnsgevydavtkTWhgpaddaSLGELAPEWYAAGARLIGGCCRTTPEDIAALAAALKT 304
PLN02489 PLN02489
homocysteine S-methyltransferase
 9-90 7.87e-07

homocysteine S-methyltransferase


Pssm-ID: 215269  Cd Length: 335  Bit Score: 49.63  E-value: 7.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616238   9 AKKGILERL--NAGEIVIGDGGFVFALEKRGYVKAGP-WTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLEN 85
Cdd:PLN02489   7 QMSSLLEDLlrQAGGCAVIDGGFATELERHGADLNDPlWSAKCLITSPHLIRKVHLDYLEAGADIIITASYQATIQGFES 86


                 ....*
gi 119616238  86 RGASI 90
Cdd:PLN02489  87 RGLSR 91
MetH1 COG0646
Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport ...
 10-84 3.52e-06

Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Methionine synthase I (cobalamin-dependent), methyltransferase domain is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440411 [Multi-domain]  Cd Length: 809  Bit Score: 48.31  E-value: 3.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616238  10 KKGILERLnAGEIVIGDGGFVFALEKRGyVKAGPWTPEAA------VEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKL 83
Cdd:COG0646    3 RAALLELL-KERILILDGAMGTMLQAYG-LTEGDFRGEKGcnellnLTRPDVIREIHRAYLEAGADIIETNTFGANRIKL 80


                 .
gi 119616238  84 E 84
Cdd:COG0646   81 A 81
MetH1 COG0646
Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport ...
 75-213 4.44e-06

Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Methionine synthase I (cobalamin-dependent), methyltransferase domain is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440411 [Multi-domain]  Cd Length: 809  Bit Score: 47.92  E-value: 4.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616238  75 TFYASedkLENRGASIIGVNCHFDPtislktvKLMKEGLEAARLKA--HLMSQPLAyhtpdcnkqGfidLPEfPFGLEpr 152
Cdd:COG0646  206 AFATS---LEHLGPDAIGLNCALGP-------DEMRPHVEELSEVAdtPVSAYPNA---------G---LPN-LVGGR-- 260

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119616238 153 vaTRWDIQ-----KYAREAYNLG-VRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWgSGL 213
Cdd:COG0646  261 --TVYDETpeemaEYAEEFAEAGgVNIVGGCCGTTPEHIRAIAEAVKGLPPRKRPPPPPALRL-SGL 324
metH TIGR02082
5-methyltetrahydrofolate--homocysteine methyltransferase; This family represents ...
 76-203 4.45e-06

5-methyltetrahydrofolate--homocysteine methyltransferase; This family represents 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13), one of at least three different enzymes able to convert homocysteine to methionine by transferring a methyl group on to the sulfur atom. It is also called the vitamin B12(or cobalamine)-dependent methionine synthase. Other methionine synthases include 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (MetE, EC 2.1.1.14, the cobalamin-independent methionine synthase) and betaine-homocysteine methyltransferase. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 273959 [Multi-domain]  Cd Length: 1181  Bit Score: 47.85  E-value: 4.45e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119616238    76 FYASedkLENRGASIIGVNCHFDPtislktvKLMKEGLEaaRLKAHlMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVAt 155
Cdd:TIGR02082  218 FLTS---LEHAGIDMIGLNCALGP-------DEMRPHLK--HLSEH-AEAYVSCHPNAGLPNAFGEYDLTPDELAKALA- 283

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 119616238   156 rwdiqKYAREaynLGVRYIGGCCGFEPYHIRAIAEELA----PERGFLPPAS 203
Cdd:TIGR02082  284 -----DFAAE---GGLNIVGGCCGTTPDHIRAIAEAVKnikpRQRPVLYEPS 327
PRK07534 PRK07534
betaine--homocysteine S-methyltransferase;
162-193 2.00e-04

betaine--homocysteine S-methyltransferase;


Pssm-ID: 236045 [Multi-domain]  Cd Length: 336  Bit Score: 42.04  E-value: 2.00e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 119616238 162 YAREAYNLGVRYIGGCCGFEPYHIRAIAEELA 193
Cdd:PRK07534 263 YAVLARDAGARIIGGCCGTMPEHLAAMRAALD 294
metH PRK09490
B12-dependent methionine synthase; Provisional
 159-201 1.71e-03

B12-dependent methionine synthase; Provisional


Pssm-ID: 236539 [Multi-domain]  Cd Length: 1229  Bit Score: 39.78  E-value: 1.71e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 119616238  159 IQKYAREAYnlgVRYIGGCCGFEPYHIRAIAEELAPergfLPP 201
Cdd:PRK09490  298 IGEFAESGF---LNIVGGCCGTTPEHIAAIAEAVAG----LPP 333
MetH2 COG1410
Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; ...
 143-194 5.35e-03

Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Methionine synthase I, cobalamin-binding domain is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 441020 [Multi-domain]  Cd Length: 1141  Bit Score: 38.40  E-value: 5.35e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 119616238  143 PEFPFGLEPRVATRWDIQKYAREAynlGVRYIGGCCGFEPYHIRAIAEELAP 194
Cdd:COG1410   257 NGFGEYDETPEEMAAALAEFAEEG---GVNIVGGCCGTTPEHIRAIAEAVAG 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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