NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|119611228|gb|EAW90822|]
View 

SFT2 domain containing 2 [Homo sapiens]

Protein Classification

Got1/Sft2-like family vesicle transport protein( domain architecture ID 10514491)

Got1/Sft2-like family vesicle transport protein similar to vesicle transport protein SFT2A/2B/2C that may be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Got1 pfam04178
Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the ...
 34-145 5.03e-34

Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the syntaxin family of SNARE proteins, Sed5, present in early Golgi cisternae. Got1 is thought to facilitate Sed5-dependent fusion events. This is a family of sequences derived from eukaryotic proteins. They are similar to a region of a SNARE-like protein required for traffic through the Golgi complex, SFT2 protein. This is a conserved protein with four putative transmembrane helices, thought to be involved in vesicular transport in later Golgi compartments.


:

Pssm-ID: 461210  Cd Length: 110  Bit Score: 115.28  E-value: 5.03e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119611228   34 IKGFIACFAIGILCSLLGTVLLWVPRkgLHLFAVFYTFGNIASIGSTIFLMGPVKQLKRMFEPTRLIATIMVLLCFALTL 113
Cdd:pfam04178   1 LIGFGICLLLGVLCFFLSFFLFVLAK--PRKFALLYTLGNILFLGSTGFLIGPKKQLKHMFSKERLPFTIAYLGSLLLTL 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 119611228  114 CSAFWWHNKGLALIFCILQSLALTWYSLSFIP 145
Cdd:pfam04178  79 YFALILKSYGLTLLFSIIQFLALVWYFLSYIP 110
 
Name Accession Description Interval E-value
Got1 pfam04178
Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the ...
 34-145 5.03e-34

Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the syntaxin family of SNARE proteins, Sed5, present in early Golgi cisternae. Got1 is thought to facilitate Sed5-dependent fusion events. This is a family of sequences derived from eukaryotic proteins. They are similar to a region of a SNARE-like protein required for traffic through the Golgi complex, SFT2 protein. This is a conserved protein with four putative transmembrane helices, thought to be involved in vesicular transport in later Golgi compartments.


Pssm-ID: 461210  Cd Length: 110  Bit Score: 115.28  E-value: 5.03e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119611228   34 IKGFIACFAIGILCSLLGTVLLWVPRkgLHLFAVFYTFGNIASIGSTIFLMGPVKQLKRMFEPTRLIATIMVLLCFALTL 113
Cdd:pfam04178   1 LIGFGICLLLGVLCFFLSFFLFVLAK--PRKFALLYTLGNILFLGSTGFLIGPKKQLKHMFSKERLPFTIAYLGSLLLTL 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 119611228  114 CSAFWWHNKGLALIFCILQSLALTWYSLSFIP 145
Cdd:pfam04178  79 YFALILKSYGLTLLFSIIQFLALVWYFLSYIP 110
SFT2 COG5102
Membrane protein involved in ER to Golgi transport [Intracellular trafficking and secretion];
16-152 3.82e-10

Membrane protein involved in ER to Golgi transport [Intracellular trafficking and secretion];


Pssm-ID: 227433  Cd Length: 201  Bit Score: 56.08  E-value: 3.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119611228  16 RSGLSEVVEAS--SLSWSTRIKGFIACFAIGILCSLLGTVLLWVPRKGLHLFAVFYTFGNIASIGSTIFLMGPVKQLKRM 93
Cdd:COG5102   48 KYDLEHYFQSSefGLSRFERAVLFSACLLGAGACSAFLYFMFPVLRLKPRKFILLWTMGSLLFVLMFGFLLGFRAYLEGL 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 119611228  94 FEPTRLIATIMVLLCFALTLCSAFWWHNKGLALIFCILQSLALTWYSLSFIPFARDAVK 152
Cdd:COG5102  128 TSKERLPHSSWFFGTTLLTIYVVLKYKRTLLNIAFCFLQVVSFIMYSITFFPFGTSGVS 186
 
Name Accession Description Interval E-value
Got1 pfam04178
Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the ...
 34-145 5.03e-34

Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the syntaxin family of SNARE proteins, Sed5, present in early Golgi cisternae. Got1 is thought to facilitate Sed5-dependent fusion events. This is a family of sequences derived from eukaryotic proteins. They are similar to a region of a SNARE-like protein required for traffic through the Golgi complex, SFT2 protein. This is a conserved protein with four putative transmembrane helices, thought to be involved in vesicular transport in later Golgi compartments.


Pssm-ID: 461210  Cd Length: 110  Bit Score: 115.28  E-value: 5.03e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119611228   34 IKGFIACFAIGILCSLLGTVLLWVPRkgLHLFAVFYTFGNIASIGSTIFLMGPVKQLKRMFEPTRLIATIMVLLCFALTL 113
Cdd:pfam04178   1 LIGFGICLLLGVLCFFLSFFLFVLAK--PRKFALLYTLGNILFLGSTGFLIGPKKQLKHMFSKERLPFTIAYLGSLLLTL 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 119611228  114 CSAFWWHNKGLALIFCILQSLALTWYSLSFIP 145
Cdd:pfam04178  79 YFALILKSYGLTLLFSIIQFLALVWYFLSYIP 110
SFT2 COG5102
Membrane protein involved in ER to Golgi transport [Intracellular trafficking and secretion];
16-152 3.82e-10

Membrane protein involved in ER to Golgi transport [Intracellular trafficking and secretion];


Pssm-ID: 227433  Cd Length: 201  Bit Score: 56.08  E-value: 3.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119611228  16 RSGLSEVVEAS--SLSWSTRIKGFIACFAIGILCSLLGTVLLWVPRKGLHLFAVFYTFGNIASIGSTIFLMGPVKQLKRM 93
Cdd:COG5102   48 KYDLEHYFQSSefGLSRFERAVLFSACLLGAGACSAFLYFMFPVLRLKPRKFILLWTMGSLLFVLMFGFLLGFRAYLEGL 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 119611228  94 FEPTRLIATIMVLLCFALTLCSAFWWHNKGLALIFCILQSLALTWYSLSFIPFARDAVK 152
Cdd:COG5102  128 TSKERLPHSSWFFGTTLLTIYVVLKYKRTLLNIAFCFLQVVSFIMYSITFFPFGTSGVS 186
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH