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Conserved domains on  [gi|119609296|gb|EAW88890|]
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FK506 binding protein 4, 59kDa, isoform CRA_a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
43-134 4.82e-43

FKBP-type peptidyl-prolyl cis-trans isomerase;


:

Pssm-ID: 459735  Cd Length: 94  Bit Score: 146.96  E-value: 4.82e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296   43 GTEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGS-PPK 121
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPV 80

                          90
                  ....*....|...
gi 119609296  122 IPPNATLVFEVEL 134
Cdd:pfam00254  81 IPPNATLVFEVEL 93
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
275-429 2.27e-18

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 83.81  E-value: 2.27e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 275 ERGTVYFKEGKYKQALlqykkivswleyeSSFSneeaqkaQALRL-----ASHLNLAMCHLKLQAFSAAIESCNKALELD 349
Cdd:COG4785   78 ERGVAYDSLGDYDLAI-------------ADFD-------QALELdpdlaEAYNNRGLAYLLLGDYDAALEDFDRALELD 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 350 SNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREkKLYANMFERLAEEENKAKAEA 429
Cdd:COG4785  138 PDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAERKLDPEKALA-LLLEDWATAYLLQGDTEEARE 216
FKBP_N_2 super family cl39441
BDBT FKBP like N-terminal; This is the N-terminal domain of the beta chain found in Drosophila ...
 144-253 7.72e-03

BDBT FKBP like N-terminal; This is the N-terminal domain of the beta chain found in Drosophila melanogaster protein BDBT (a FK506-Binding Protein) which stimulates the DBT circadian function. The domain contains the DBT-binding site. The domain is structurally homologous to the peptidyl prolyl isomerase (PPIase) regions of FK506-binding proteins despite low sequence homology. BDBT is structurally related to the immunophilin FKBP51 and it shares a common domain organization consisting of PPIase-like and TPR domains with noncanonical immunophilins such as FKBP38 or FKBPL.


The actual alignment was detected with superfamily member pfam18023:

Pssm-ID: 375495  Cd Length: 113  Bit Score: 36.25  E-value: 7.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296  144 EEEDGGIIRRIQTRGEGY-AKPNEGAIVEVALEGY---------YKDKLFDQRELRFEIGEGENlDLPYGLERAIQRMEK 213
Cdd:pfam18023   2 ESADKSISKEVLSFGFQGlEKPTEVSSCIVLVENLqnvtlrkdqGLEKYYIYEEKEIVIGEADT-PIDEYIEILLEMMKL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 119609296  214 GEHSIVylkpSYAFGSVGKEKFQIPpnaeLKYELHLKSFE 253
Cdd:pfam18023  81 GETAEC----TIATKTGESGTGDII----IKFELTLIKIE 112
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
43-134 4.82e-43

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 146.96  E-value: 4.82e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296   43 GTEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGS-PPK 121
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPV 80

                          90
                  ....*....|...
gi 119609296  122 IPPNATLVFEVEL 134
Cdd:pfam00254  81 IPPNATLVFEVEL 93
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 35-134 1.06e-41

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 143.40  E-value: 1.06e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296  35 KVIKrEGTGtEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYG 114
Cdd:COG0545    4 KVLK-EGTG-AKPKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYG 81

                         90       100
                 ....*....|....*....|
gi 119609296 115 SAGSPPKIPPNATLVFEVEL 134
Cdd:COG0545   82 ERGAGGVIPPNSTLVFEVEL 101
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
275-429 2.27e-18

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 83.81  E-value: 2.27e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 275 ERGTVYFKEGKYKQALlqykkivswleyeSSFSneeaqkaQALRL-----ASHLNLAMCHLKLQAFSAAIESCNKALELD 349
Cdd:COG4785   78 ERGVAYDSLGDYDLAI-------------ADFD-------QALELdpdlaEAYNNRGLAYLLLGDYDAALEDFDRALELD 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 350 SNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREkKLYANMFERLAEEENKAKAEA 429
Cdd:COG4785  138 PDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAERKLDPEKALA-LLLEDWATAYLLQGDTEEARE 216
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 28-138 2.67e-18

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 84.43  E-value: 2.67e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296  28 KQDEGVLKVIKREGTGtEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKgeVIKAWDIAIATMKVGEVCHITC 107
Cdd:PRK10902 143 TTSTGLLYKVEKEGTG-EAPKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDG--VIPGWTEGLKNIKKGGKIKLVI 219

                         90       100       110
                 ....*....|....*....|....*....|.
gi 119609296 108 KPEYAYGSAGSpPKIPPNATLVFEVELFEFK 138
Cdd:PRK10902 220 PPELAYGKAGV-PGIPANSTLVFDVELLDVK 249
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 250-395 1.75e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.02  E-value: 1.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296  250 KSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEyessfsneeaQKAQALRLashlnLAMCH 329
Cdd:TIGR02917 275 KNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAP----------NSHQARRL-----LASIQ 339

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119609296  330 LKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAV 395
Cdd:TIGR02917 340 LRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGI 405
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 323-390 1.67e-06

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 49.55  E-value: 1.67e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119609296 323 LNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAK 390
Cdd:cd24142    4 LEKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGYEK 71
TPR_1 pfam00515
Tetratricopeptide repeat;
321-352 6.84e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 39.71  E-value: 6.84e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 119609296  321 SHLNLAMCHLKLQAFSAAIESCNKALELDSNN 352
Cdd:pfam00515   3 ALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 326-439 1.01e-04

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 44.39  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 326 AMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNkaaktqlavcqqrirrqlA 405
Cdd:PLN03088  43 AQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEEYQTAKAALEKGASLAPGD------------------S 104

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 119609296 406 REKKLYANMFERLAEEEN-----KAKAEASSGDHPTDTE 439
Cdd:PLN03088 105 RFTKLIKECDEKIAEEEKdlvqpVPSDLPSSVTAPPVEE 143
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 322-352 1.30e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 38.97  E-value: 1.30e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 119609296   322 HLNLAMCHLKLQAFSAAIESCNKALELDSNN 352
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
FKBP_N_2 pfam18023
BDBT FKBP like N-terminal; This is the N-terminal domain of the beta chain found in Drosophila ...
 144-253 7.72e-03

BDBT FKBP like N-terminal; This is the N-terminal domain of the beta chain found in Drosophila melanogaster protein BDBT (a FK506-Binding Protein) which stimulates the DBT circadian function. The domain contains the DBT-binding site. The domain is structurally homologous to the peptidyl prolyl isomerase (PPIase) regions of FK506-binding proteins despite low sequence homology. BDBT is structurally related to the immunophilin FKBP51 and it shares a common domain organization consisting of PPIase-like and TPR domains with noncanonical immunophilins such as FKBP38 or FKBPL.


Pssm-ID: 375495  Cd Length: 113  Bit Score: 36.25  E-value: 7.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296  144 EEEDGGIIRRIQTRGEGY-AKPNEGAIVEVALEGY---------YKDKLFDQRELRFEIGEGENlDLPYGLERAIQRMEK 213
Cdd:pfam18023   2 ESADKSISKEVLSFGFQGlEKPTEVSSCIVLVENLqnvtlrkdqGLEKYYIYEEKEIVIGEADT-PIDEYIEILLEMMKL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 119609296  214 GEHSIVylkpSYAFGSVGKEKFQIPpnaeLKYELHLKSFE 253
Cdd:pfam18023  81 GETAEC----TIATKTGESGTGDII----IKFELTLIKIE 112
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
43-134 4.82e-43

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 146.96  E-value: 4.82e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296   43 GTEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGS-PPK 121
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPV 80

                          90
                  ....*....|...
gi 119609296  122 IPPNATLVFEVEL 134
Cdd:pfam00254  81 IPPNATLVFEVEL 93
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 35-134 1.06e-41

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 143.40  E-value: 1.06e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296  35 KVIKrEGTGtEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYG 114
Cdd:COG0545    4 KVLK-EGTG-AKPKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYG 81

                         90       100
                 ....*....|....*....|
gi 119609296 115 SAGSPPKIPPNATLVFEVEL 134
Cdd:COG0545   82 ERGAGGVIPPNSTLVFEVEL 101
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
275-429 2.27e-18

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 83.81  E-value: 2.27e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 275 ERGTVYFKEGKYKQALlqykkivswleyeSSFSneeaqkaQALRL-----ASHLNLAMCHLKLQAFSAAIESCNKALELD 349
Cdd:COG4785   78 ERGVAYDSLGDYDLAI-------------ADFD-------QALELdpdlaEAYNNRGLAYLLLGDYDAALEDFDRALELD 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 350 SNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREkKLYANMFERLAEEENKAKAEA 429
Cdd:COG4785  138 PDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAERKLDPEKALA-LLLEDWATAYLLQGDTEEARE 216
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 28-138 2.67e-18

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 84.43  E-value: 2.67e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296  28 KQDEGVLKVIKREGTGtEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKgeVIKAWDIAIATMKVGEVCHITC 107
Cdd:PRK10902 143 TTSTGLLYKVEKEGTG-EAPKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDG--VIPGWTEGLKNIKKGGKIKLVI 219

                         90       100       110
                 ....*....|....*....|....*....|.
gi 119609296 108 KPEYAYGSAGSpPKIPPNATLVFEVELFEFK 138
Cdd:PRK10902 220 PPELAYGKAGV-PGIPANSTLVFDVELLDVK 249
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 4-136 1.23e-17

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 81.00  E-value: 1.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296   4 EEMKATESGAQSAPLpmegvdispKQDEGVLkvikregtgtemPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGK 83
Cdd:PRK11570  95 EGVNSTESGLQFRVL---------TQGEGAI------------PARTDRVRVHYTGKLIDGTVFDSSVARGEPAEFPVNG 153

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 119609296  84 geVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFE 136
Cdd:PRK11570 154 --VIPGWIEALTLMPVGSKWELTIPHELAYGERGAGASIPPFSTLVFEVELLE 204
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
276-402 4.76e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.88  E-value: 4.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 276 RGTVYFKEGKYKQALLQYKKIVS-WLEYESSFSN-----------EEAQKA--QALRL-----ASHLNLAMCHLKLQAFS 336
Cdd:COG0457   14 LGLAYRRLGRYEEAIEDYEKALElDPDDAEALYNlglaylrlgryEEALADyeQALELdpddaEALNNLGLALQALGRYE 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119609296 337 AAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRR 402
Cdd:COG0457   94 EALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGR 159
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 277-400 3.44e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 68.48  E-value: 3.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 277 GTVYFKEGKYKQALLQYKKIvswLEYESSFsneeaqkAQAlrlasHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGL 356
Cdd:COG3914  119 GNLLLALGRLEEALAALRRA---LALNPDF-------AEA-----YLNLGEALRRLGRLEEAIAALRRALELDPDNAEAL 183

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 119609296 357 FRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRI 400
Cdd:COG3914  184 NNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQA 227
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 267-402 1.44e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.56  E-value: 1.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 267 LEQSTIVKERGTVYFKEGKYKQALLQYKKivswleyessfsneeAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKAL 346
Cdd:COG3914   75 LLLAALLELAALLLQALGRYEEALALYRR---------------ALALNPDNAEALFNLGNLLLALGRLEEALAALRRAL 139

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 119609296 347 ELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRR 402
Cdd:COG3914  140 ALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGR 195
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 238-429 4.36e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 63.21  E-value: 4.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 238 PPNAELKYEL-----HLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVswleyessfsNEEAQ 312
Cdd:COG2956   73 PDRAEALLELaqdylKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLL----------KLGPE 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 313 KAQAlrlasHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQ 392
Cdd:COG2956  143 NAHA-----YCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPR 217

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 119609296 393 LAVCQQRIRR------------QLAREKKLYANMFERLAEEENKAKAEA 429
Cdd:COG2956  218 LAELYEKLGDpeealellrkalELDPSDDLLLALADLLERKEGLEAALA 266
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
321-402 6.20e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 62.33  E-value: 6.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 321 SHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRI 400
Cdd:COG0457   10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQAL 89


                 ..
gi 119609296 401 RR 402
Cdd:COG0457   90 GR 91
SlpA COG1047
Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein ...
 50-145 7.09e-11

Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440668 [Multi-domain]  Cd Length: 138  Bit Score: 59.73  E-value: 7.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296  50 GDRVFVHYTGWLLDGTKFDSSLDRkDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGsagsppkiPPNATLV 129
Cdd:COG1047    4 GDVVTLHYTLKLEDGEVFDSTFEG-EPLEFLHGAGQLIPGLEEALEGMEVGDKKTVTLPPEEAYG--------ERDPELV 74

                         90
                 ....*....|....*.
gi 119609296 130 FEVELFEFKGEDLTEE 145
Cdd:COG1047   75 QTVPREQFPEDEELEV 90
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
247-429 8.51e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.95  E-value: 8.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 247 LHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIvswLEYESSFSNeeaqkaqalrlaSHLNLA 326
Cdd:COG0457   53 LRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKA---LELDPDDAE------------ALYNLG 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 327 MCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAR 406
Cdd:COG0457  118 LALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLL 197

                        170       180
                 ....*....|....*....|...
gi 119609296 407 EKKLYANMFERLAEEENKAKAEA 429
Cdd:COG0457  198 ALLLALEQALRKKLAILTLAALA 220
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 322-430 1.41e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 58.86  E-value: 1.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 322 HLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVC-QQRI 400
Cdd:COG4235   20 WLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAaFQQG 99

                         90       100       110
                 ....*....|....*....|....*....|
gi 119609296 401 RRQLAREkkLYANMFERLAEEENKAKAEAS 430
Cdd:COG4235  100 DYAEAIA--AWQKLLALLPADAPARLLEAS 127
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 276-386 4.32e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 57.51  E-value: 4.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 276 RGTVYFKEGKYKQALLQYkkivswleyessfsnEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKG 355
Cdd:COG4783   44 LGEILLQLGDLDEAIVLL---------------HEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEA 108

                         90       100       110
                 ....*....|....*....|....*....|.
gi 119609296 356 LFRRGEAHLAVNDFELARADFQKVLQLYPNN 386
Cdd:COG4783  109 YLRLARAYRALGRPDEAIAALEKALELDPDD 139
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 280-390 5.18e-10

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 56.54  E-value: 5.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 280 YFKEGKYKQALLQYKKIVSwlEYESSfsneeaqkaqALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEK---GL 356
Cdd:COG1729    3 LLKAGDYDEAIAAFKAFLK--RYPNS----------PLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdAL 70

                         90       100       110
                 ....*....|....*....|....*....|....
gi 119609296 357 FRRGEAHLAVNDFELARADFQKVLQLYPNNKAAK 390
Cdd:COG1729   71 LKLGLSYLELGDYDKARATLEELIKKYPDSEAAK 104
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 252-394 2.33e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 58.20  E-value: 2.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 252 FEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSwleyessfsnEEAQKAQALRLashlnLAMCHLK 331
Cdd:COG2956   58 YDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLE----------LDPDDAEALRL-----LAEIYEQ 122

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119609296 332 LQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLA 394
Cdd:COG2956  123 EGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLA 185
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 288-410 4.95e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 54.97  E-value: 4.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 288 QALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVN 367
Cdd:COG5010   23 LVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSG 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 119609296 368 DFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKL 410
Cdd:COG5010  103 DKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAAL 145
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 275-426 7.25e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 56.66  E-value: 7.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 275 ERGTVYFKEGKYKQALLQYKKIVswleyESSFSNEEAqkaqalrlasHLNLAMCHLKLQAFSAAIESCNKALELDSNNEK 354
Cdd:COG2956   13 FKGLNYLLNGQPDKAIDLLEEAL-----ELDPETVEA----------HLALGNLYRRRGEYDRAIRIHQKLLERDPDRAE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 355 GLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIR---------RQLAREKKLYANMFERLAEEENKA 425
Cdd:COG2956   78 ALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGdwekaievlERLLKLGPENAHAYCELAELYLEQ 157


                 .
gi 119609296 426 K 426
Cdd:COG2956  158 G 158
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 275-410 1.08e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 53.66  E-value: 1.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 275 ERGTVYFKEGKYKQALLQYKKIVswleyESSFSNEEAqkaqalrlasHLNLAMCHLKLQAFSAAIESCNKALELDSNNEK 354
Cdd:COG4783    9 ALAQALLLAGDYDEAEALLEKAL-----ELDPDNPEA----------FALLGEILLQLGDLDEAIVLLHEALELDPDEPE 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 119609296 355 GLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKL 410
Cdd:COG4783   74 ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAAL 129
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 250-395 1.75e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.02  E-value: 1.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296  250 KSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEyessfsneeaQKAQALRLashlnLAMCH 329
Cdd:TIGR02917 275 KNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAP----------NSHQARRL-----LASIQ 339

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119609296  330 LKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAV 395
Cdd:TIGR02917 340 LRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGI 405
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
279-385 2.46e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 51.32  E-value: 2.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 279 VYFKEGKYKQALLQYKKivswleyessfsneeAQKAQALRLASHLNLAMCHLKLQAFSAAIEsCNKALELDSNNEKGLFR 358
Cdd:COG3063    1 LYLKLGDLEEAEEYYEK---------------ALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLN 64

                         90       100
                 ....*....|....*....|....*..
gi 119609296 359 RGEAHLAVNDFELARADFQKVLQLYPN 385
Cdd:COG3063   65 LAELLLELGDYDEALAYLERALELDPS 91
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 337-394 6.33e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 51.16  E-value: 6.33e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 119609296 337 AAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLA 394
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLA 58
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 307-402 1.78e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 53.46  E-value: 1.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 307 SNEEAQKAQALRLASHLNLAMCHLKLQA---FSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLY 383
Cdd:COG3914   63 AAGEAAAAAAALLLLAALLELAALLLQAlgrYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALN 142

                         90
                 ....*....|....*....
gi 119609296 384 PNNKAAKTQLAVCQQRIRR 402
Cdd:COG3914  143 PDFAEAYLNLGEALRRLGR 161
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 274-384 2.68e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 49.96  E-value: 2.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 274 KERGTVYFKEGKYKQALLQYKKIVswleyESSFSNEEAqkaqalrlasHLNLAMCHLKLQAFSAAIESCNKALELDSNNE 353
Cdd:COG5010   58 SPSDNLYNKLGDFEESLALLEQAL-----QLDPNNPEL----------YYNLALLYSRSGDKDEAKEYYEKALALSPDNP 122

                         90       100       110
                 ....*....|....*....|....*....|.
gi 119609296 354 KGLFRRGEAHLAVNDFELARADFQKVLQLYP 384
Cdd:COG5010  123 NAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
322-389 5.77e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 50.30  E-value: 5.77e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119609296 322 HLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAA 389
Cdd:COG4785   76 YYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYA 143
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 240-399 6.49e-07

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 51.91  E-value: 6.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296  240 NAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRL 319
Cdd:TIGR00990 283 SNELDEETGNGQLQLGLKSPESKADESYEEAARAFEKALDLGKLGEKEAIALNLRGTFKCLKGKHLEALADLSKSIELDP 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296  320 A---SHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVC 396
Cdd:TIGR00990 363 RvtqSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFIFSHIQLGVT 442


                  ...
gi 119609296  397 QQR 399
Cdd:TIGR00990 443 QYK 445
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 316-399 1.31e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.49  E-value: 1.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 316 ALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAV 395
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGL 80


                 ....
gi 119609296 396 CQQR 399
Cdd:COG4783   81 ALLK 84
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 323-390 1.67e-06

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 49.55  E-value: 1.67e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119609296 323 LNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAK 390
Cdd:cd24142    4 LEKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGYEK 71
OM_YfiO TIGR03302
outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a ...
 275-411 1.97e-06

outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a near-essential protein of the outer membrane, part of a complex involved in protein insertion into the bacterial outer membrane. Many proteins in this family are annotated as ComL, based on the involvement of this protein in natural transformation with exogenous DNA in Neisseria gonorrhoeae. This protein family shows sequence similarity to, but is distinct from, the tol-pal system protein YbgF (TIGR02795). [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274513 [Multi-domain]  Cd Length: 235  Bit Score: 48.70  E-value: 1.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296  275 ERGTVYFKEGKYKQALLQYKKIVSwlEYESSfsnEEAQKAQalrlashLNLAMCHLKLQAFSAAIESCNKALELDSNNEK 354
Cdd:TIGR03302  38 EEAKEALDSGDYTEAIKYFEALES--RYPFS---PYAEQAQ-------LDLAYAYYKSGDYAEAIAAADRFIRLHPNHPD 105

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119609296  355 ---GLFRRGEAHLA-VNDFE-------LARADFQKVLQLYPNNK---AAKTQLAVCqqriRRQLArEKKLY 411
Cdd:TIGR03302 106 adyAYYLRGLSNYNqIDRVDrdqtaarEAFEAFQELIRRYPNSEyapDAKKRMDYL----RNRLA-GKELY 171
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 309-425 2.02e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 50.47  E-value: 2.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296  309 EEAQKAQALrlaSHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKA 388
Cdd:TIGR02917 458 EKKQPDNAS---LHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLR 534

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 119609296  389 AKTQLAvcqqRIRRQLAREKKlYANMFERLAEEENKA 425
Cdd:TIGR02917 535 AILALA----GLYLRTGNEEE-AVAWLEKAAELNPQE 566
BamD COG4105
Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope ...
 251-406 2.93e-06

Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443281 [Multi-domain]  Cd Length: 254  Bit Score: 48.34  E-value: 2.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 251 SFEKAKESWemnSEEKLeqstivKERGTVYFKEGKYKQALLQYKKIVSWLEYessfsNEEAQKAQalrlashLNLAMCHL 330
Cdd:COG4105   22 SFKKALKSW---DAEEL------YEEAKEALEKGDYEKAIKLFEELEPRYPG-----SPYAEQAQ-------LMLAYAYY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 331 KLQAFSAAIESCNKALELDSNNEK---GLFRRGEAH-LAVNDFEL-------ARADFQKVLQLYPNNKAAktqlAVCQQR 399
Cdd:COG4105   81 KQGDYEEAIAAADRFIKLYPNSPNadyAYYLRGLSYyEQSPDSDRdqtstrkAIEAFQELINRYPDSEYA----EDAKKR 156

                        170
                 ....*....|
gi 119609296 400 I---RRQLAR 406
Cdd:COG4105  157 IdelRDKLAR 166
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
264-426 3.13e-05

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 45.26  E-value: 3.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 264 EEKLEQSTIVKER---GTVYFKEGKYKQALLQYkkivswleyESSFSNEEAQKAQALrlashLNLAMCHLKLQAFSAAIE 340
Cdd:COG4700   80 EKALEFADTVQNRvrlADALLELGRYDEAIELY---------EEALTGIFADDPHIL-----LGLAQALFELGRYAEALE 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 341 SCNKALELDSNnekglFRRGEAHL-------AVNDFELARADFQKVLQLYPNNKA----------------AKTQLAVCQ 397
Cdd:COG4700  146 TLEKLIAKNPD-----FKSSDAHLlyaraleALGDLEAAEAELEALARRYSGPEAryryakflarqgrtaeAKELLEEIL 220

                        170       180
                 ....*....|....*....|....*....
gi 119609296 398 QRIRRQLAREKKLYANMFERLAEEENKAK 426
Cdd:COG4700  221 DEAKHMPKHYRRLNREWIREAKKLLKSLR 249
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
305-402 6.44e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 44.14  E-value: 6.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 305 SFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDsNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYP 384
Cdd:COG4785   26 LAALLFAAVLALAIALADLALALAAAALAAAALAAERIDRALALP-DLAQLYYERGVAYDSLGDYDLAIADFDQALELDP 104

                         90
                 ....*....|....*...
gi 119609296 385 NNKAAKTQLAVCQQRIRR 402
Cdd:COG4785  105 DLAEAYNNRGLAYLLLGD 122
TPR_1 pfam00515
Tetratricopeptide repeat;
321-352 6.84e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 39.71  E-value: 6.84e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 119609296  321 SHLNLAMCHLKLQAFSAAIESCNKALELDSNN 352
Cdd:pfam00515   3 ALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 326-439 1.01e-04

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 44.39  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 326 AMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNkaaktqlavcqqrirrqlA 405
Cdd:PLN03088  43 AQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEEYQTAKAALEKGASLAPGD------------------S 104

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 119609296 406 REKKLYANMFERLAEEEN-----KAKAEASSGDHPTDTE 439
Cdd:PLN03088 105 RFTKLIKECDEKIAEEEKdlvqpVPSDLPSSVTAPPVEE 143
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 322-352 1.30e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 38.97  E-value: 1.30e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 119609296   322 HLNLAMCHLKLQAFSAAIESCNKALELDSNN 352
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_1 pfam00515
Tetratricopeptide repeat;
354-386 3.29e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 37.79  E-value: 3.29e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 119609296  354 KGLFRRGEAHLAVNDFELARADFQKVLQLYPNN 386
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
346-402 6.31e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.15  E-value: 6.31e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 119609296 346 LELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRR 402
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGR 57
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 354-385 6.42e-04

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 37.12  E-value: 6.42e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 119609296  354 KGLFRRGEAHLAVNDFELARADFQKVLQLYPN 385
Cdd:pfam07719   2 EALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 316-422 6.45e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.64  E-value: 6.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 316 ALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAv 395
Cdd:COG2956    5 VAAALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELA- 83

                         90       100       110
                 ....*....|....*....|....*....|
gi 119609296 396 cqqrirrQLAREKKLYA---NMFERLAEEE 422
Cdd:COG2956   84 -------QDYLKAGLLDraeELLEKLLELD 106
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 276-430 8.19e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.99  E-value: 8.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296  276 RGTVYFKEGKYKQALLQYKKI--------------VSWLEYESSFsnEEAQK-AQALR------LASHLNLAMCHLKLQA 334
Cdd:TIGR02917 199 KGDLLLSLGNIELALAAYRKAialrpnniavllalATILIEAGEF--EEAEKhADALLkkapnsPLAHYLKALVDFQKKN 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296  335 FSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRR------------ 402
Cdd:TIGR02917 277 YEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRvdeaiatlspal 356

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 119609296  403 ----------QLAREKKLYANMFERLAEEENKAKAEAS 430
Cdd:TIGR02917 357 gldpddpaalSLLGEAYLALGDFEKAAEYLAKATELDP 394
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 354-386 1.66e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.89  E-value: 1.66e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 119609296   354 KGLFRRGEAHLAVNDFELARADFQKVLQLYPNN 386
Cdd:smart00028   2 EALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 308-386 1.88e-03

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 39.63  E-value: 1.88e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119609296  308 NEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNN 386
Cdd:TIGR02521  20 RSSRTTDRNKAAKIRVQLALGYLEQGDLEVAKENLDKALEHDPDDYLAYLALALYYQQLGELEKAEDSFRRALTLNPNN 98
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 310-434 4.01e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.02  E-value: 4.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296 310 EAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAA 389
Cdd:COG5010   11 PLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPEL 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 119609296 390 KTQLAVCQQRI-RRQLARE--KKLYANMFERLAEEENKAKAEASSGDH 434
Cdd:COG5010   91 YYNLALLYSRSgDKDEAKEyyEKALALSPDNPNAYSNLAALLLSLGQD 138
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 261-376 4.54e-03

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 39.58  E-value: 4.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296  261 MNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNeeaqkaqalrlashlnLAMCHLKLQAFSAAIE 340
Cdd:TIGR00990 118 LSEEERKKYAAKLKEKGNKAYRNKDFNKAIKLYSKAIECKPDPVYYSN----------------RAACHNALGDWEKVVE 181

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 119609296  341 SCNKALELDSNNEKGLFRRGEAHLAVNDFELARADF 376
Cdd:TIGR00990 182 DTTAALELDPDYSKALNRRANAYDGLGKYADALLDL 217
FKBP_N_2 pfam18023
BDBT FKBP like N-terminal; This is the N-terminal domain of the beta chain found in Drosophila ...
 144-253 7.72e-03

BDBT FKBP like N-terminal; This is the N-terminal domain of the beta chain found in Drosophila melanogaster protein BDBT (a FK506-Binding Protein) which stimulates the DBT circadian function. The domain contains the DBT-binding site. The domain is structurally homologous to the peptidyl prolyl isomerase (PPIase) regions of FK506-binding proteins despite low sequence homology. BDBT is structurally related to the immunophilin FKBP51 and it shares a common domain organization consisting of PPIase-like and TPR domains with noncanonical immunophilins such as FKBP38 or FKBPL.


Pssm-ID: 375495  Cd Length: 113  Bit Score: 36.25  E-value: 7.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296  144 EEEDGGIIRRIQTRGEGY-AKPNEGAIVEVALEGY---------YKDKLFDQRELRFEIGEGENlDLPYGLERAIQRMEK 213
Cdd:pfam18023   2 ESADKSISKEVLSFGFQGlEKPTEVSSCIVLVENLqnvtlrkdqGLEKYYIYEEKEIVIGEADT-PIDEYIEILLEMMKL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 119609296  214 GEHSIVylkpSYAFGSVGKEKFQIPpnaeLKYELHLKSFE 253
Cdd:pfam18023  81 GETAEC----TIATKTGESGTGDII----IKFELTLIKIE 112
TPR_12 pfam13424
Tetratricopeptide repeat;
317-385 8.21e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 35.06  E-value: 8.21e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119609296  317 LRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKG--------LFRRGEAHLAVNDFELARADFQKVLQLYPN 385
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPdhpltattLLNLGRLYLELGRYEEALELLERALALAEK 77
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 277-395 9.53e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.53  E-value: 9.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119609296  277 GTVYFKEGKYKQALLQYKKIVSwLEYEssfsneeaqKAQALRLashlnLAMCHLKLQAFSAAIESCNKALELDSNNE-KG 355
Cdd:TIGR02917  63 GKIYLALGDYAAAEKELRKALS-LGYP---------KNQVLPL-----LARAYLLQGKFQQVLDELPGKTLLDDEGAaEL 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 119609296  356 LFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAV 395
Cdd:TIGR02917 128 LALRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQ 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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