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Conserved domains on  [gi|119608254|gb|EAW87848|]
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phytanoyl-CoA dioxygenase domain containing 1, isoform CRA_b [Homo sapiens]

Protein Classification

2OG-Fe(II) oxygenase family protein( domain architecture ID 229412)

2OG-Fe(II) oxygenase family protein belongs to the large and diverse Fe(II)- and 2-oxoglutarate (2-OG)-dependent dioxygenase superfamily and may share a common reaction mechanism, using Fe(II) and the cosubstrate 2-OG in the active site to activate oxygen, resulting in the two-electron oxidation of a target substrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2OG-FeII_Oxy super family cl21496
2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and ...
 12-149 5.82e-16

2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily. This family includes the C-terminal of prolyl 4-hydroxylase alpha subunit. The holoenzyme has the activity EC:1.14.11.2 catalysing the reaction: Procollagen L-proline + 2-oxoglutarate + O2 <=> procollagen trans- 4-hydroxy-L-proline + succinate + CO2. The full enzyme consists of a alpha2 beta2 complex with the alpha subunit contributing most of the parts of the active site. The family also includes lysyl hydrolases, isopenicillin synthases and AlkB.


The actual alignment was detected with superfamily member pfam05721:

Pssm-ID: 473886  Cd Length: 213  Bit Score: 74.80  E-value: 5.82e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119608254   12 FQQDGFLVLEGFLSAEECVAMQQRIGEIVaemdvplhcrtefstqeeeqlraqgstDYFLSSGDKIRFFFEKGVFDEKGN 91
Cdd:pfam05721   1 FREDGYLVIEGFLSPEEVAALRAEAERLL---------------------------DRAAESGPDKDDFFDEKAAGDETG 53

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119608254   92 FLvppEKSINKIGHALHAhdpvfksithsFKVQTLARSLGLQMPVVV---QSMY----IFKSPLI 149
Cdd:pfam05721  54 LL---EKSITKRDHFLHP-----------FYLADLARAILGSPVYVAnvlQSMYqdlsIFKQPGT 104
 
Name Accession Description Interval E-value
PhyH pfam05721
Phytanoyl-CoA dioxygenase (PhyH); This family is made up of several eukaryotic phytanoyl-CoA ...
 12-149 5.82e-16

Phytanoyl-CoA dioxygenase (PhyH); This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalysing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.


Pssm-ID: 399029  Cd Length: 213  Bit Score: 74.80  E-value: 5.82e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119608254   12 FQQDGFLVLEGFLSAEECVAMQQRIGEIVaemdvplhcrtefstqeeeqlraqgstDYFLSSGDKIRFFFEKGVFDEKGN 91
Cdd:pfam05721   1 FREDGYLVIEGFLSPEEVAALRAEAERLL---------------------------DRAAESGPDKDDFFDEKAAGDETG 53

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119608254   92 FLvppEKSINKIGHALHAhdpvfksithsFKVQTLARSLGLQMPVVV---QSMY----IFKSPLI 149
Cdd:pfam05721  54 LL---EKSITKRDHFLHP-----------FYLADLARAILGSPVYVAnvlQSMYqdlsIFKQPGT 104
PhyH COG5285
Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family [Secondary ...
 4-147 4.58e-11

Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 444095  Cd Length: 237  Bit Score: 61.59  E-value: 4.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119608254   4 LSPSQLQKFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMdvplhcrtefstqeeeqlRAQGSTDYFLSSGDKIRFFFEk 83
Cdd:COG5285    2 LTDEQIAFFERDGYLVLRGVLSPEEVAALRAALDRLLAEA------------------PDEGDLEYSEADGGRLRRIYN- 62

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119608254  84 gvfdekgnflvppeksinkighaLHAHDPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKSP 147
Cdd:COG5285   63 -----------------------LHRRDPAFRDLARHPRILAVAEQLLGPDVRLHHSQLFFKPP 103
 
Name Accession Description Interval E-value
PhyH pfam05721
Phytanoyl-CoA dioxygenase (PhyH); This family is made up of several eukaryotic phytanoyl-CoA ...
 12-149 5.82e-16

Phytanoyl-CoA dioxygenase (PhyH); This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalysing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.


Pssm-ID: 399029  Cd Length: 213  Bit Score: 74.80  E-value: 5.82e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119608254   12 FQQDGFLVLEGFLSAEECVAMQQRIGEIVaemdvplhcrtefstqeeeqlraqgstDYFLSSGDKIRFFFEKGVFDEKGN 91
Cdd:pfam05721   1 FREDGYLVIEGFLSPEEVAALRAEAERLL---------------------------DRAAESGPDKDDFFDEKAAGDETG 53

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119608254   92 FLvppEKSINKIGHALHAhdpvfksithsFKVQTLARSLGLQMPVVV---QSMY----IFKSPLI 149
Cdd:pfam05721  54 LL---EKSITKRDHFLHP-----------FYLADLARAILGSPVYVAnvlQSMYqdlsIFKQPGT 104
PhyH COG5285
Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family [Secondary ...
 4-147 4.58e-11

Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 444095  Cd Length: 237  Bit Score: 61.59  E-value: 4.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119608254   4 LSPSQLQKFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMdvplhcrtefstqeeeqlRAQGSTDYFLSSGDKIRFFFEk 83
Cdd:COG5285    2 LTDEQIAFFERDGYLVLRGVLSPEEVAALRAALDRLLAEA------------------PDEGDLEYSEADGGRLRRIYN- 62

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119608254  84 gvfdekgnflvppeksinkighaLHAHDPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKSP 147
Cdd:COG5285   63 -----------------------LHRRDPAFRDLARHPRILAVAEQLLGPDVRLHHSQLFFKPP 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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