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Conserved domains on  [gi|119604770|gb|EAW84364|]
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calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, isoform CRA_d [Homo sapiens]

Protein Classification

voltage-dependent calcium channel subunit alpha-1( domain architecture ID 11999358)

voltage-dependent calcium channel subunit alpha-1 is part of a multisubunit voltage-dependent calcium channel that mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1565-1822 1.87e-71

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 239.86  E-value: 1.87e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770  1565 SPPFEYTIMAMIALNTIVLMMKFYGAS-VAYENALRVFNIVFTSLFSLECVLKVMAFGI-LNYFRDAWNIFDFVTVLGSI 1642
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770  1643 TDILVTEFGNnFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVE 1722
Cdd:pfam00520   81 ISLVLSSVGS-LSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770  1723 DedsdedefQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLsgkpcdknsgiltRECGNEFAYFYFVSFIFLCSFLM 1802
Cdd:pfam00520  160 N--------PDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTI-------------DGKGEFWAYIYFVSFIILGGFLL 218

                          250       260
                   ....*....|....*....|
gi 119604770  1803 LNLFVAVIMDNFEYLTRDSS 1822
Cdd:pfam00520  219 LNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 99-372 7.96e-68

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 229.46  E-value: 7.96e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770    99 SPFEYMILATIIANCIVLALEQHLPDDDKTPmsERLDDTEPYFIGIFCFEAGIKIIALGFAFHkgsYLRNGWNVMDFVVV 178
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLT--TVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVV 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770   179 LTGILATVGTE----FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFH 254
Cdd:pfam00520   77 LPSLISLVLSSvgslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770   255 TtcfeegtddiqgespapcgteepartcpngtkcqpyWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGN 334
Cdd:pfam00520  157 T------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 119604770   335 TWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVE 372
Cdd:pfam00520  201 FWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 487-725 6.49e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 197.87  E-value: 6.49e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770   487 QAFYWTVLSLVALNTLCVAIVHYNQPEW-LSDFLYYAEFIFLGLFMSEMFIKMYGLG-TRPYFHSSFNCFDCGVIIGSIF 564
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGfKKRYFRSPWNILDFVVVLPSLI 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770   565 EVIWAVIKPGtsFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDE 644
Cdd:pfam00520   82 SLVLSSVGSL--SGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770   645 G--TPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSqggvQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQE 722
Cdd:pfam00520  160 NpdNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDG----KGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235


                   ...
gi 119604770   723 LTK 725
Cdd:pfam00520  236 RTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1244-1475 2.58e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 196.33  E-value: 2.58e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770  1244 RYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHqgaYFRDLWNILDFIVVSG 1323
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVLP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770  1324 ALVAFAFTGNSKGKDINtikSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKF 1403
Cdd:pfam00520   79 SLISLVLSSVGSLSGLR---VLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119604770  1404 fhctdeskefekdcrgkyllyeKNEVKARDREWkkyefHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFE 1475
Cdd:pfam00520  156 ----------------------KTWENPDNGRT-----NFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
 1894-1971 5.23e-35

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


:

Pssm-ID: 462591  Cd Length: 77  Bit Score: 128.87  E-value: 5.23e-35
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119604770  1894 NSTLMALIRTALDIKIAKGGaDKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKA 1971
Cdd:pfam08763    1 TATLFALIRTSLKIKLAPAG-EMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
 1831-1884 2.54e-29

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


:

Pssm-ID: 465306  Cd Length: 54  Bit Score: 111.98  E-value: 2.54e-29
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 119604770  1831 EYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLP 1884
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 2234-2504 9.28e-12

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 70.97  E-value: 9.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2234 PDHGRARARDQRWSRSPSEGREHMahrqgSSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPHVS--YSPVIRK--AGG 2309
Cdd:PHA03307  128 PSPAPDLSEMLRPVGSPGPPPAAS-----PPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSppAEPPPSTppAAA 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2310 SGPPQQQQQQQQQQQQQAVARPGRAATSGPRR-------YPGPTAEPLAGDRPPTGGHSSGRSPRMERRV---------P 2373
Cdd:PHA03307  203 SPRPPRRSSPISASASSPAPAPGRSAADDAGAsssdsssSESSGCGWGPENECPLPRPAPITLPTRIWEAsgwngpssrP 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2374 GPARSESPRACRHGgaRWPASGPHVSEGPPGPRHHGYYRGSDYDEADGPGSGGGEEAMAGAYDAPPPVRHASSG-----A 2448
Cdd:PHA03307  283 GPASSSSSPRERSP--SPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSrppppA 360

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2449 TGRSPR-------------------TPRASGPACA-------SPSRHGRRLPNGYYPAHGLARPRGPGSRKGLH---EPY 2499
Cdd:PHA03307  361 DPSSPRkrprpsrapsspaasagrpTRRRARAAVAgrarrrdATGRFPAGRPRPSPLDAGAASGAFYARYPLLTpsgEPW 440


                  ....*
gi 119604770 2500 SESDD 2504
Cdd:PHA03307  441 PGSPP 445
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1565-1822 1.87e-71

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 239.86  E-value: 1.87e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770  1565 SPPFEYTIMAMIALNTIVLMMKFYGAS-VAYENALRVFNIVFTSLFSLECVLKVMAFGI-LNYFRDAWNIFDFVTVLGSI 1642
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770  1643 TDILVTEFGNnFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVE 1722
Cdd:pfam00520   81 ISLVLSSVGS-LSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770  1723 DedsdedefQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLsgkpcdknsgiltRECGNEFAYFYFVSFIFLCSFLM 1802
Cdd:pfam00520  160 N--------PDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTI-------------DGKGEFWAYIYFVSFIILGGFLL 218

                          250       260
                   ....*....|....*....|
gi 119604770  1803 LNLFVAVIMDNFEYLTRDSS 1822
Cdd:pfam00520  219 LNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 99-372 7.96e-68

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 229.46  E-value: 7.96e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770    99 SPFEYMILATIIANCIVLALEQHLPDDDKTPmsERLDDTEPYFIGIFCFEAGIKIIALGFAFHkgsYLRNGWNVMDFVVV 178
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLT--TVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVV 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770   179 LTGILATVGTE----FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFH 254
Cdd:pfam00520   77 LPSLISLVLSSvgslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770   255 TtcfeegtddiqgespapcgteepartcpngtkcqpyWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGN 334
Cdd:pfam00520  157 T------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 119604770   335 TWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVE 372
Cdd:pfam00520  201 FWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 487-725 6.49e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 197.87  E-value: 6.49e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770   487 QAFYWTVLSLVALNTLCVAIVHYNQPEW-LSDFLYYAEFIFLGLFMSEMFIKMYGLG-TRPYFHSSFNCFDCGVIIGSIF 564
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGfKKRYFRSPWNILDFVVVLPSLI 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770   565 EVIWAVIKPGtsFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDE 644
Cdd:pfam00520   82 SLVLSSVGSL--SGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770   645 G--TPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSqggvQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQE 722
Cdd:pfam00520  160 NpdNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDG----KGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235


                   ...
gi 119604770   723 LTK 725
Cdd:pfam00520  236 RTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1244-1475 2.58e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 196.33  E-value: 2.58e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770  1244 RYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHqgaYFRDLWNILDFIVVSG 1323
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVLP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770  1324 ALVAFAFTGNSKGKDINtikSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKF 1403
Cdd:pfam00520   79 SLISLVLSSVGSLSGLR---VLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119604770  1404 fhctdeskefekdcrgkyllyeKNEVKARDREWkkyefHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFE 1475
Cdd:pfam00520  156 ----------------------KTWENPDNGRT-----NFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
 1894-1971 5.23e-35

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 128.87  E-value: 5.23e-35
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119604770  1894 NSTLMALIRTALDIKIAKGGaDKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKA 1971
Cdd:pfam08763    1 TATLFALIRTSLKIKLAPAG-EMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
 1831-1884 2.54e-29

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 111.98  E-value: 2.54e-29
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 119604770  1831 EYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLP 1884
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2234-2504 9.28e-12

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 70.97  E-value: 9.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2234 PDHGRARARDQRWSRSPSEGREHMahrqgSSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPHVS--YSPVIRK--AGG 2309
Cdd:PHA03307  128 PSPAPDLSEMLRPVGSPGPPPAAS-----PPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSppAEPPPSTppAAA 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2310 SGPPQQQQQQQQQQQQQAVARPGRAATSGPRR-------YPGPTAEPLAGDRPPTGGHSSGRSPRMERRV---------P 2373
Cdd:PHA03307  203 SPRPPRRSSPISASASSPAPAPGRSAADDAGAsssdsssSESSGCGWGPENECPLPRPAPITLPTRIWEAsgwngpssrP 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2374 GPARSESPRACRHGgaRWPASGPHVSEGPPGPRHHGYYRGSDYDEADGPGSGGGEEAMAGAYDAPPPVRHASSG-----A 2448
Cdd:PHA03307  283 GPASSSSSPRERSP--SPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSrppppA 360

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2449 TGRSPR-------------------TPRASGPACA-------SPSRHGRRLPNGYYPAHGLARPRGPGSRKGLH---EPY 2499
Cdd:PHA03307  361 DPSSPRkrprpsrapsspaasagrpTRRRARAAVAgrarrrdATGRFPAGRPRPSPLDAGAASGAFYARYPLLTpsgEPW 440


                  ....*
gi 119604770 2500 SESDD 2504
Cdd:PHA03307  441 PGSPP 445
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
 1949-1979 1.16e-10

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 58.00  E-value: 1.16e-10
                            10        20        30
                    ....*....|....*....|....*....|.
gi 119604770   1949 TDLTVGKIYAAMMIMEYYRQSKAKKLQAMRE 1979
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 1998-2498 9.59e-05

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 47.75  E-value: 9.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 1998 QEGGPGQNAL--PSTQLDPG-GALMAHESGLKESPSwVTQRAQEMFQKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRD 2074
Cdd:COG5180     7 LEIRLLATVPipPNAARPVLsPELWAAANNDAVSQG-DRSALASSPTRPYARKIFEPLDIKLALGKPQLPSVAEPEAYLD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2075 -----GYSDSEHYLPMEGQG-----RAASMPRLPAENQRRRGRPRGNnLSTISDTSPMKRSASVL--GPKARRLDDYSLE 2142
Cdd:COG5180    86 pappkSSPDTPEEQLGAPAGdllvlPAAKTPELAAGALPAPAAAAAL-PKAKVTREATSASAGVAlaAALLQRSDPILAK 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2143 R---------VPPEENQRHHQRRRDRSHRASERSLGRYTD--VDTGLGTDLSMTTQSgDLPSKERDQER--GRPKDRKHR 2209
Cdd:COG5180   165 DpdgdsastlPPPAEKLDKVLTEPRDALKDSPEKLDRPKVevKDEAQEEPPDLTGGA-DHPRPEAASSPkvDPPSTSEAR 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2210 QHHHHHHHHHHPPPPDKDRYAQERPDHGRARARDQ-----RWSRSPSEGREHMAHRQGSSSVSGSPAPSTSGTSTPRRGR 2284
Cdd:COG5180   244 SRPATVDAQPEMRPPADAKERRRAAIGDTPAAEPPglpvlEAGSEPQSDAPEAETARPIDVKGVASAPPATRPVRPPGGA 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2285 RQlpqtPSTPRP-HVSYSPVirkaggsgppqqqqqqqqqqqqqavARPGRAATSGPRrypgPTAEPLAGDRPPTgghssg 2363
Cdd:COG5180   324 RD----PGTPRPgQPTERPA-------------------------GVPEAASDAGQP----PSAYPPAEEAVPG------ 364

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2364 rSPrMERRVPGPARSESPRACRHGGARWPA-SGPHVSEGPPGPRH----HGYYRGSD--YDEADGPGSGGGEEAMAGAYD 2436
Cdd:COG5180   365 -KP-LEQGAPRPGSSGGDGAPFQPPNGAPQpGLGRRGAPGPPMGAgdlvQAALDGGGreTASLGGAAGGAGQGPKADFVP 442

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119604770 2437 APPPVRHASSGATGRS----------PRTPRASGPACASPS----RHGRRLPNGYYPAHGLARPRGPGSRKGLHEP 2498
Cdd:COG5180   443 GDAESVSGPAGLADQAgaaastamadFVAPVTDATPVDVADvlgvRPDAILGGNVAPASGLDAETRIIEAEGAPAT 518
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 2329-2461 3.81e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 42.06  E-value: 3.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2329 ARPGRAATSGPRRYPGPTAEPLAGDRPPTGGHSSGRSPRMERRVPGPARSESPRAcRHGGARWPASGPHVSEGPPGPRHH 2408
Cdd:NF040712  193 GRPLRPLATVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARR-RRAGVEQPEDEPVGPGAAPAAEPD 271

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 119604770 2409 GYYRGSDYDEADGPGSGGGEE---AMAGAYDAPPPVRHASSGATGRSPRTPRASGP 2461
Cdd:NF040712  272 EATRDAGEPPAPGAAETPEAAeppAPAPAAPAAPAAPEAEEPARPEPPPAPKPKRR 327
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
 629-722 9.69e-03

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 41.47  E-value: 9.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770  629 ALLGMQLFGGQFnfdegtppTNFDTFPAAIMTVFQILTGeDWNEVMYDgIKSQGGVQGgMVFSIYFIVLTLFGNYTLLNV 708
Cdd:PLN03223 1345 AFIGHVIFGNAS--------VHFSDMTDSINSLFENLLG-DITYFNED-LKNLTGLQF-VVGMIYFYSYNIFVFMILFNF 1413

                          90
                  ....*....|....*...
gi 119604770  709 FLAIAVDNL----ANAQE 722
Cdd:PLN03223 1414 LLAIICDAFgevkANAAE 1431
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1565-1822 1.87e-71

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 239.86  E-value: 1.87e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770  1565 SPPFEYTIMAMIALNTIVLMMKFYGAS-VAYENALRVFNIVFTSLFSLECVLKVMAFGI-LNYFRDAWNIFDFVTVLGSI 1642
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770  1643 TDILVTEFGNnFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVE 1722
Cdd:pfam00520   81 ISLVLSSVGS-LSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770  1723 DedsdedefQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLsgkpcdknsgiltRECGNEFAYFYFVSFIFLCSFLM 1802
Cdd:pfam00520  160 N--------PDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTI-------------DGKGEFWAYIYFVSFIILGGFLL 218

                          250       260
                   ....*....|....*....|
gi 119604770  1803 LNLFVAVIMDNFEYLTRDSS 1822
Cdd:pfam00520  219 LNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 99-372 7.96e-68

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 229.46  E-value: 7.96e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770    99 SPFEYMILATIIANCIVLALEQHLPDDDKTPmsERLDDTEPYFIGIFCFEAGIKIIALGFAFHkgsYLRNGWNVMDFVVV 178
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLT--TVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVV 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770   179 LTGILATVGTE----FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFH 254
Cdd:pfam00520   77 LPSLISLVLSSvgslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770   255 TtcfeegtddiqgespapcgteepartcpngtkcqpyWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGN 334
Cdd:pfam00520  157 T------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 119604770   335 TWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVE 372
Cdd:pfam00520  201 FWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 487-725 6.49e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 197.87  E-value: 6.49e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770   487 QAFYWTVLSLVALNTLCVAIVHYNQPEW-LSDFLYYAEFIFLGLFMSEMFIKMYGLG-TRPYFHSSFNCFDCGVIIGSIF 564
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGfKKRYFRSPWNILDFVVVLPSLI 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770   565 EVIWAVIKPGtsFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDE 644
Cdd:pfam00520   82 SLVLSSVGSL--SGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770   645 G--TPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSqggvQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQE 722
Cdd:pfam00520  160 NpdNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDG----KGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235


                   ...
gi 119604770   723 LTK 725
Cdd:pfam00520  236 RTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1244-1475 2.58e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 196.33  E-value: 2.58e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770  1244 RYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHqgaYFRDLWNILDFIVVSG 1323
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVLP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770  1324 ALVAFAFTGNSKGKDINtikSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKF 1403
Cdd:pfam00520   79 SLISLVLSSVGSLSGLR---VLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119604770  1404 fhctdeskefekdcrgkyllyeKNEVKARDREWkkyefHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFE 1475
Cdd:pfam00520  156 ----------------------KTWENPDNGRT-----NFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
 1894-1971 5.23e-35

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 128.87  E-value: 5.23e-35
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119604770  1894 NSTLMALIRTALDIKIAKGGaDKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKA 1971
Cdd:pfam08763    1 TATLFALIRTSLKIKLAPAG-EMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
 1831-1884 2.54e-29

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 111.98  E-value: 2.54e-29
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 119604770  1831 EYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLP 1884
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2234-2504 9.28e-12

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 70.97  E-value: 9.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2234 PDHGRARARDQRWSRSPSEGREHMahrqgSSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPHVS--YSPVIRK--AGG 2309
Cdd:PHA03307  128 PSPAPDLSEMLRPVGSPGPPPAAS-----PPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSppAEPPPSTppAAA 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2310 SGPPQQQQQQQQQQQQQAVARPGRAATSGPRR-------YPGPTAEPLAGDRPPTGGHSSGRSPRMERRV---------P 2373
Cdd:PHA03307  203 SPRPPRRSSPISASASSPAPAPGRSAADDAGAsssdsssSESSGCGWGPENECPLPRPAPITLPTRIWEAsgwngpssrP 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2374 GPARSESPRACRHGgaRWPASGPHVSEGPPGPRHHGYYRGSDYDEADGPGSGGGEEAMAGAYDAPPPVRHASSG-----A 2448
Cdd:PHA03307  283 GPASSSSSPRERSP--SPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSrppppA 360

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2449 TGRSPR-------------------TPRASGPACA-------SPSRHGRRLPNGYYPAHGLARPRGPGSRKGLH---EPY 2499
Cdd:PHA03307  361 DPSSPRkrprpsrapsspaasagrpTRRRARAAVAgrarrrdATGRFPAGRPRPSPLDAGAASGAFYARYPLLTpsgEPW 440


                  ....*
gi 119604770 2500 SESDD 2504
Cdd:PHA03307  441 PGSPP 445
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
 1949-1979 1.16e-10

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 58.00  E-value: 1.16e-10
                            10        20        30
                    ....*....|....*....|....*....|.
gi 119604770   1949 TDLTVGKIYAAMMIMEYYRQSKAKKLQAMRE 1979
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
 1604-1815 5.91e-10

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 61.91  E-value: 5.91e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770  1604 VFTSLFSLECVLKVMAFGiLNYFRDAWNIFDFVTVLGSITDILvtefgnnfinLSFLRLFRAARLIKLLRQ--------- 1674
Cdd:pfam08016   19 VFFLYFVVEEILKIRKHR-PSYLRSVWNLLDLAIVILSVVLIV----------LNIYRDFLADRLIKSVEAspvtfidfd 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770  1675 -----GYTIRIL-----------LWTFVQSFK-----------ALPYVC---LLIAMLFFIYAIIGMQVFGNigidvede 1724
Cdd:pfam08016   88 rvaqlDNLYRIIlaflvfltwlkLFKVLRFNKtmslftktlsrAWKDLAgfaLMFVIFFFAYAQFGYLLFGT-------- 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770  1725 dsdedefqitEHNNFRTFFQALMLLFRSATG-EAWHNImlsclsgKPCDKNSGILtrecgnefayfYFVSFIFLCSFLML 1803
Cdd:pfam08016  160 ----------QAPNFSNFVKSILTLFRTILGdFGYNEI-------FSGNRVLGPL-----------LFLTFVFLVIFILL 211

                          250
                   ....*....|..
gi 119604770  1804 NLFVAVIMDNFE 1815
Cdd:pfam08016  212 NLFLAIINDSYV 223
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 2249-2460 5.90e-08

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 58.46  E-value: 5.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2249 SPSEGREHMAHRQGSSSVSGSPAPSTSGTSTPRRgrrqlPQTPSTPRPHVSYSPVIRKAGGSGPPQQQQQQQQQQQQQAV 2328
Cdd:PRK07764  604 ASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPA-----EASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAP 678

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2329 ARPGRAATSGPRRYPGPTAEPLAGDRPPTGGHSSgrsprmerrvPGPARSESPRACRHGGARWPASGPHVSEGPPGPRHH 2408
Cdd:PRK07764  679 AAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAG----------QADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDP 748

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 119604770 2409 GYYRGSDYDEADGPGSGGGEEAMAGAYDAPPP-----VRHASSGATGRSPRTPRASG 2460
Cdd:PRK07764  749 PDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSeeeemAEDDAPSMDDEDRRDAEEVA 805
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2263-2492 1.56e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.26  E-value: 1.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2263 SSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPHvsySPVI--RKAGGSGPPQQQQQQQQQQQQQAVARPGRAATSGP- 2339
Cdd:PHA03247 2544 ASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPS---EPAVtsRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPd 2620

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2340 --RRYPGPTAEPLAGDRPPTGGHSSGRSPRMERRVPGPARSESPRACRHGGA---------RW------PASG------- 2395
Cdd:PHA03247 2621 thAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRaaqassppqRPrrraarPTVGsltslad 2700

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2396 PHVSEGPPGPRHHGYYRGSDYdeADGPGSGGGEEAMAGAYDAPPPVRHASS--GATGRSPRTPRASGPACASPSRH---- 2469
Cdd:PHA03247 2701 PPPPPPTPEPAPHALVSATPL--PPGPAAARQASPALPAAPAPPAVPAGPAtpGGPARPARPPTTAGPPAPAPPAApaag 2778

                         250       260
                  ....*....|....*....|....
gi 119604770 2470 -GRRLPNGYYPAHGLARPRGPGSR 2492
Cdd:PHA03247 2779 pPRRLTRPAVASLSESRESLPSPW 2802
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2233-2489 1.12e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 1.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2233 RPDHGRARARDQRWSrSPSEGREHMAHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPHVSYSPVIRKAGGSGP 2312
Cdd:PHA03247 2663 RPRRARRLGRAAQAS-SPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAP 2741

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2313 PQQQQQQQQQQQQQAVARPgrAATSGPRRyPGPTAEPLAG-----DRPPTGGHSSGR----SPR----MERRVPGPARSE 2379
Cdd:PHA03247 2742 PAVPAGPATPGGPARPARP--PTTAGPPA-PAPPAAPAAGpprrlTRPAVASLSESReslpSPWdpadPPAAVLAPAAAL 2818

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2380 SPRACRHGGARWP-ASGPHVSEGPPGPrhhgyyrgsdydeADGPGSGGGEEAMAGAYDAPPPVRHASSG-ATGRSPRTPR 2457
Cdd:PHA03247 2819 PPAASPAGPLPPPtSAQPTAPPPPPGP-------------PPPSLPLGGSVAPGGDVRRRPPSRSPAAKpAAPARPPVRR 2885

                         250       260       270
                  ....*....|....*....|....*....|..
gi 119604770 2458 ASGPAcasPSRHGRRLPngyYPAHGLARPRGP 2489
Cdd:PHA03247 2886 LARPA---VSRSTESFA---LPPDQPERPPQP 2911
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2250-2492 1.95e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 1.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2250 PSEGREHMAHRQGSSSVSGSP------APSTSGTSTPRRGRR-----QLPQTPSTPRPHVSYSPVIRKAGGSGPPQQQQQ 2318
Cdd:PHA03247 2628 PPSPSPAANEPDPHPPPTVPPperprdDPAPGRVSRPRRARRlgraaQASSPPQRPRRRAARPTVGSLTSLADPPPPPPT 2707

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2319 QQQQQQQQAVARPGRAATSGPRR-YPGPTAEPLAgdRPPTGGHSSGRSPRMERRVPGPARSESPRAcrhggARWPASGPH 2397
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQaSPALPAAPAP--PAVPAGPATPGGPARPARPPTTAGPPAPAP-----PAAPAAGPP 2780

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2398 VSEGPPGPRHHGYYRGS---DYDEADGPGSGGGEEAMAGAYDAP----PPVRHASSGATGRSPRTPRASGPACASPSRHG 2470
Cdd:PHA03247 2781 RRLTRPAVASLSESRESlpsPWDPADPPAAVLAPAAALPPAASPagplPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGG 2860

                         250       260
                  ....*....|....*....|....*
gi 119604770 2471 ---RRLPNGYYPAHGLARPRGPGSR 2492
Cdd:PHA03247 2861 dvrRRPPSRSPAAKPAAPARPPVRR 2885
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 2247-2498 3.80e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 52.68  E-value: 3.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2247 SRSPSEGREHMAHRQGSSSVSGSPAPsTSGTSTPRRGRRQLPQTPSTPRPHVSYSPVIRKAGGSGPPQQQQQQQQQQQQQ 2326
Cdd:PRK07764  383 RRLGVAGGAGAPAAAAPSAAAAAPAA-APAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAA 461

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2327 AVARPGRAATSGPRRYPGPTAEPLAGDRPPTgghsSGRSPRMERRVPGPARSESPR---------ACRHGGARWPASGPH 2397
Cdd:PRK07764  462 PSAQPAPAPAAAPEPTAAPAPAPPAAPAPAA----APAAPAAPAAPAGADDAATLRerwpeilaaVPKRSRKTWAILLPE 537

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2398 VSEGPP-------------------GPRHHGYYRGSDYDE-------------ADGPGSGGGEEAMAGAYDAPPPVRHAS 2445
Cdd:PRK07764  538 ATVLGVrgdtlvlgfstgglarrfaSPGNAEVLVTALAEElggdwqveavvgpAPGAAGGEGPPAPASSGPPEEAARPAA 617

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 119604770 2446 SGATGRSPRTPRASGPACASPSRHGRRLPNGYYPAHGLARPRGPGSRKGLHEP 2498
Cdd:PRK07764  618 PAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWP 670
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
2257-2474 1.81e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 50.26  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2257 MAHRQGSSSVSGSPAPSTSGT-STPRRGRRQLPQTPSTPRPHVSYSPVIRKAGGSGPPQQQQQQQQQQQQQAVA----RP 2331
Cdd:PRK12323  361 LAFRPGQSGGGAGPATAAAAPvAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAaarqAS 440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2332 GRAATSGPRRYPGPTAEPLAGDRPPTGGhSSGRSPRMERRVPGPARSESPRACRHGGARW---PASGPHVSEGPPGPRHH 2408
Cdd:PRK12323  441 ARGPGGAPAPAPAPAAAPAAAARPAAAG-PRPVAAAAAAAPARAAPAAAPAPADDDPPPWeelPPEFASPAPAQPDAAPA 519

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2409 GYYRGSDYDEADGPGSGGGEEAMAGAYDAPPPVRHASSG--ATGRSPRTPRASGPACASPSRHG--RRLP 2474
Cdd:PRK12323  520 GWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEpvVAPRPPRASASGLPDMFDGDWPAlaARLP 589
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2262-2505 1.96e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.17  E-value: 1.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2262 GSSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPHVSYSPviRKAGGSGPPqqqqqqqqqqqqqavarpgraaTSGPRR 2341
Cdd:PHA03307   60 AACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASP--AREGSPTPP----------------------GPSSPD 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2342 YPGPTAEPLAGDRPPTGGHSSgrSPRMERRVPGPARSESPRAcrhggarwPASGPHVSEGPPGPRHHGYYRGSDYDEADG 2421
Cdd:PHA03307  116 PPPPTPPPASPPPSPAPDLSE--MLRPVGSPGPPPAASPPAA--------GASPAAVASDAASSRQAALPLSSPEETARA 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2422 PGSGGgeeamagaydAPPPVRHASSGATGRSPRT--PRASGPACASPSrhgrrlpngyyPAHGLARPRGPGSRKGLHEPY 2499
Cdd:PHA03307  186 PSSPP----------AEPPPSTPPAAASPRPPRRssPISASASSPAPA-----------PGRSAADDAGASSSDSSSSES 244


                  ....*.
gi 119604770 2500 SESDDD 2505
Cdd:PHA03307  245 SGCGWG 250
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2234-2494 2.07e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2234 PDHGRARA----RDQRWSRSPSEGREHMAHRQGSSSVSGSPAPSTSG----TSTPRRGRRQLPQTPSTPRPHVSYSPVIR 2305
Cdd:PHA03247 2593 PQSARPRApvddRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDphppPTVPPPERPRDDPAPGRVSRPRRARRLGR 2672

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2306 KAGGSGPPQQQQQQQQQQQQQAVARPGRAATSGPRRYPGPTAEPLAGDRPPTGGHSSGRSPRMERRVPGPARSESPRAcr 2385
Cdd:PHA03247 2673 AAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT-- 2750

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2386 HGGARWPASgPHVSEGPPGPRHHGYYRGSDYDEADGPGSGGGEEAMAGAYDAPPPVRHASSgATGRSPRTPRASGPACAS 2465
Cdd:PHA03247 2751 PGGPARPAR-PPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA-VLAPAAALPPAASPAGPL 2828

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 119604770 2466 P-----SRHGRRLPNG----YYPAHGLARPRGPGSRKG 2494
Cdd:PHA03247 2829 PpptsaQPTAPPPPPGppppSLPLGGSVAPGGDVRRRP 2866
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 2327-2505 2.35e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 49.98  E-value: 2.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2327 AVARPGRAATSGPRRYPGPTAEPLAGDRPPTGGHSSGRsprmerrvPGPARSESPRAcrhGGARWPASGPhvseGPPGPR 2406
Cdd:PRK07764  587 VVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAP--------AAPAPAGAAAA---PAEASAAPAP----GVAAPE 651

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2407 HHGYYRGSDYDEADGPGSGGGEEAMAGAYDAPPPVRHASSGATGRSPR--TPRASGPacASPSRHGRRLPNGYYPAHGLA 2484
Cdd:PRK07764  652 HHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAqpAPAPAAT--PPAGQADDPAAQPPQAAQGAS 729

                         170       180
                  ....*....|....*....|.
gi 119604770 2485 RPRGPGSRKGLHEPYSESDDD 2505
Cdd:PRK07764  730 APSPAADDPVPLPPEPDDPPD 750
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2292-2499 2.77e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.78  E-value: 2.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2292 STPRPHVSYSP-VIRKAGGSG---------PPQQQQQQQQQQQQQAVARPGRAATSGPRRYPGPTAEPLAGDRPPTGGHS 2361
Cdd:PHA03307  731 RTVAPLVRYSPrRARARASAWditdalfsnPSLVPAKLAEALALLEPAEPQRGAGSSPPVRAEAAFRRPGRLRRSGPAAD 810

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2362 SGRSPRMERRVPGPARSESPRACrhGGARWPASGPHvsegPPGPRHHGyyrGSDYDEADGPGSGGGEEAMAGAYDAPPPV 2441
Cdd:PHA03307  811 AASRTASKRKSRSHTPDGGSESS--GPARPPGAAAR----PPPARSSE---SSKSKPAAAGGRARGKNGRRRPRPPEPRA 881

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119604770 2442 RHASSGATGRSPRTPRASGPACASPSRHGRRLpnGYYPAHGLAR-------PRGPgsrkgLHEPY 2499
Cdd:PHA03307  882 RPGAAAPPKAAAAAPPAGAPAPRPRPAPRVKL--GPMPPGGPDPrggfrrvPPGD-----LHTPA 939
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1992-2404 5.30e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.01  E-value: 5.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 1992 EPPSP-TQEGGPGQNALPSTQLDPGGALMAHESGLKESPSwvtqraqemfqKTGTWSPEQGPPTDMPNSQPNSQSVEMRE 2070
Cdd:PHA03307   71 PPPGPgTEAPANESRSTPTWSLSTLAPASPAREGSPTPPG-----------PSSPDPPPPTPPPASPPPSPAPDLSEMLR 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2071 MGRDGYSDSEHYLPMEG----QGRAASMPRLPAENQRRRGRPRGNNLSTISDTSPMKRSASVLGPKARRLDdySLERVPP 2146
Cdd:PHA03307  140 PVGSPGPPPAASPPAAGaspaAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRS--SPISASA 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2147 EENQRHHQRRRDRSHRASERSLGRYTDVDTGLGTDlSMT----TQSGDLPSKERDQERGRPKDRKHrqhhhhhhHHHHPP 2222
Cdd:PHA03307  218 SSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPE-NECplprPAPITLPTRIWEASGWNGPSSRP--------GPASSS 288

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2223 PPDKDRYAQERPDHGRARARDQRWSRSPSEGREHMAH--RQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPhvsy 2300
Cdd:PHA03307  289 SSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSssSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSS---- 364

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2301 spviRKAGGSGppqqqqqqqqqqqqqavARPGRAATSGPRRYPGPTAEPLAGDRpPTGGHSSGRSPR-MERRVPGPARSE 2379
Cdd:PHA03307  365 ----PRKRPRP-----------------SRAPSSPAASAGRPTRRRARAAVAGR-ARRRDATGRFPAgRPRPSPLDAGAA 422

                         410       420       430
                  ....*....|....*....|....*....|.
gi 119604770 2380 SPRACRHG------GARWPASGPHvsegPPG 2404
Cdd:PHA03307  423 SGAFYARYplltpsGEPWPGSPPP----PPG 449
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 1998-2498 9.59e-05

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 47.75  E-value: 9.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 1998 QEGGPGQNAL--PSTQLDPG-GALMAHESGLKESPSwVTQRAQEMFQKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRD 2074
Cdd:COG5180     7 LEIRLLATVPipPNAARPVLsPELWAAANNDAVSQG-DRSALASSPTRPYARKIFEPLDIKLALGKPQLPSVAEPEAYLD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2075 -----GYSDSEHYLPMEGQG-----RAASMPRLPAENQRRRGRPRGNnLSTISDTSPMKRSASVL--GPKARRLDDYSLE 2142
Cdd:COG5180    86 pappkSSPDTPEEQLGAPAGdllvlPAAKTPELAAGALPAPAAAAAL-PKAKVTREATSASAGVAlaAALLQRSDPILAK 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2143 R---------VPPEENQRHHQRRRDRSHRASERSLGRYTD--VDTGLGTDLSMTTQSgDLPSKERDQER--GRPKDRKHR 2209
Cdd:COG5180   165 DpdgdsastlPPPAEKLDKVLTEPRDALKDSPEKLDRPKVevKDEAQEEPPDLTGGA-DHPRPEAASSPkvDPPSTSEAR 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2210 QHHHHHHHHHHPPPPDKDRYAQERPDHGRARARDQ-----RWSRSPSEGREHMAHRQGSSSVSGSPAPSTSGTSTPRRGR 2284
Cdd:COG5180   244 SRPATVDAQPEMRPPADAKERRRAAIGDTPAAEPPglpvlEAGSEPQSDAPEAETARPIDVKGVASAPPATRPVRPPGGA 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2285 RQlpqtPSTPRP-HVSYSPVirkaggsgppqqqqqqqqqqqqqavARPGRAATSGPRrypgPTAEPLAGDRPPTgghssg 2363
Cdd:COG5180   324 RD----PGTPRPgQPTERPA-------------------------GVPEAASDAGQP----PSAYPPAEEAVPG------ 364

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2364 rSPrMERRVPGPARSESPRACRHGGARWPA-SGPHVSEGPPGPRH----HGYYRGSD--YDEADGPGSGGGEEAMAGAYD 2436
Cdd:COG5180   365 -KP-LEQGAPRPGSSGGDGAPFQPPNGAPQpGLGRRGAPGPPMGAgdlvQAALDGGGreTASLGGAAGGAGQGPKADFVP 442

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119604770 2437 APPPVRHASSGATGRS----------PRTPRASGPACASPS----RHGRRLPNGYYPAHGLARPRGPGSRKGLHEP 2498
Cdd:COG5180   443 GDAESVSGPAGLADQAgaaastamadFVAPVTDATPVDVADvlgvRPDAILGGNVAPASGLDAETRIIEAEGAPAT 518
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 2327-2505 3.46e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.13  E-value: 3.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2327 AVARPGRAATSGPRRYPGPTAEPLAGDRPPTGGHSSGRSPrmerrvpGPARSESPRACRHGGARWPASGPHVSEGPPGPR 2406
Cdd:PRK07764  593 GAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGA-------AAAPAEASAAPAPGVAAPEHHPKHVAVPDASDG 665

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2407 HHGYYRGSDYDEADGPGSGGGEEAMAGAYDAPPPVRHASSGATgrsPRTPRASGPACASPSRHGRRLPNGYYPAHGLARP 2486
Cdd:PRK07764  666 GDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAAT---PPAGQADDPAAQPPQAAQGASAPSPAADDPVPLP 742

                         170
                  ....*....|....*....
gi 119604770 2487 RGPGSRKGLHEPYSESDDD 2505
Cdd:PRK07764  743 PEPDDPPDPAGAPAQPPPP 761
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2230-2383 6.85e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.16  E-value: 6.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2230 AQERPDHGRARARDQRwSRSPSEGREHMAHRQGSSSVSGSPAPST-SGTSTPRRGRRQLPQTPSTPRPHVSYSPVIRKAG 2308
Cdd:PHA03307  794 AAFRRPGRLRRSGPAA-DAASRTASKRKSRSHTPDGGSESSGPARpPGAAARPPPARSSESSKSKPAAAGGRARGKNGRR 872

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2309 GSGPPQQQQQQQQQQQQQAVARPGRAAtsGPRRYPGPTAEPLAGDRPPtgghsSGRSPRME-RRVP-----GPARSESPR 2382
Cdd:PHA03307  873 RPRPPEPRARPGAAAPPKAAAAAPPAG--APAPRPRPAPRVKLGPMPP-----GGPDPRGGfRRVPpgdlhTPAPSAAAL 945


                  .
gi 119604770 2383 A 2383
Cdd:PHA03307  946 A 946
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
2308-2493 8.40e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.87  E-value: 8.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2308 GGSGPPQQQQQQQQQQQQQAVARPGRAATSGPRRYPGPTAEPLAGDRPPTGGHSSGRSPRMErrVPGPARSESPRacRHG 2387
Cdd:PRK12323  370 GGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPE--ALAAARQASAR--GPG 445

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2388 GARWPASGPHVSEGPPGPRHHGYYRGSDYDEADGPGSGGGEEAMAGAYDAPPPVRHASSGATGRSPRTPRAS--GPACAS 2465
Cdd:PRK12323  446 GAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAApaGWVAES 525

                         170       180
                  ....*....|....*....|....*...
gi 119604770 2466 PSRHGRRLPNGYYPAHGLARPRGPGSRK 2493
Cdd:PRK12323  526 IPDPATADPDDAFETLAPAPAAAPAPRA 553
PHA03378 PHA03378
EBNA-3B; Provisional
 2281-2493 9.15e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 44.67  E-value: 9.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2281 RRGRRQLPQTPSTPR-------PHVSYSPVIRKAGGSGPPQqqqqqqqqqqqqavARPGRAATsgPRRYPGPTaeplagd 2353
Cdd:PHA03378  648 FPTPHQPPQVEITPYkptwtqiGHIPYQPSPTGANTMLPIQ--------------WAPGTMQP--PPRAPTPM------- 704

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2354 RPPTGGHSSGRSPRMerrVPGPARsesPRACRHGGARWPASGPHVSEGPPGPRHHGYYRGSDYDEADGPGSGGGEEAMAG 2433
Cdd:PHA03378  705 RPPAAPPGRAQRPAA---ATGRAR---PPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQP 778

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2434 AYDAPPPVRHASSGATgrSPRTPRASGPACASPSRhgRRLPNGYYPAHGLARPRGPGSRK 2493
Cdd:PHA03378  779 PPQAPPAPQQRPRGAP--TPQPPPQAGPTSMQLMP--RAAPGQQGPTKQILRQLLTGGVK 834
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 2329-2461 3.81e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 42.06  E-value: 3.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2329 ARPGRAATSGPRRYPGPTAEPLAGDRPPTGGHSSGRSPRMERRVPGPARSESPRAcRHGGARWPASGPHVSEGPPGPRHH 2408
Cdd:NF040712  193 GRPLRPLATVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARR-RRAGVEQPEDEPVGPGAAPAAEPD 271

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 119604770 2409 GYYRGSDYDEADGPGSGGGEE---AMAGAYDAPPPVRHASSGATGRSPRTPRASGP 2461
Cdd:NF040712  272 EATRDAGEPPAPGAAETPEAAeppAPAPAAPAAPAAPEAEEPARPEPPPAPKPKRR 327
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2267-2469 4.34e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 4.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2267 SGSPAPSTSGTSTPRRGRRQLP----QTPSTPRPHVSYSPVIRKAGGSGPPQQQQQQQQQQQQQAVARPGRA-ATSGPRR 2341
Cdd:PHA03247 2868 SRSPAAKPAAPARPPVRRLARPavsrSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPqPPLAPTT 2947

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770 2342 YPGPTAEPLAGDRPPTGGH-SSGRSPRMERRVP-------GPARSESPRAcRHGGAR---WPASGPHVSEGPPGPRH--H 2408
Cdd:PHA03247 2948 DPAGAGEPSGAVPQPWLGAlVPGRVAVPRFRVPqpapsreAPASSTPPLT-GHSLSRvssWASSLALHEETDPPPVSlkQ 3026

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119604770 2409 GYYRGSDYDEADGPGS--GGGEEAMAGAYDAPPPVRHaSSGATGRSPRTPRASgpACASPSRH 2469
Cdd:PHA03247 3027 TLWPPDDTEDSDADSLfdSDSERSDLEALDPLPPEPH-DPFAHEPDPATPEAG--ARESPSSQ 3086
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
 515-712 8.34e-03

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 40.34  E-value: 8.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770   515 LSDFLYYAEFIFLGL---FMSEMFIKmYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPG----------------T 575
Cdd:pfam08016    6 RSLFILLCEIVFVVFflyFVVEEILK-IRKHRPSYLRSVWNLLDLAIVILSVVLIVLNIYRDFladrliksveaspvtfI 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770   576 SFG------------ISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFnfd 643
Cdd:pfam08016   85 DFDrvaqldnlyriiLAFLVFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGTQA--- 161

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119604770   644 egtppTNFDTFPAAIMTVFQILTG-EDWNEVMYdgiksqggvqGGMVFSI-YFIVLTLFGNYTLLNVFLAI 712
Cdd:pfam08016  162 -----PNFSNFVKSILTLFRTILGdFGYNEIFS----------GNRVLGPlLFLTFVFLVIFILLNLFLAI 217
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
 629-722 9.69e-03

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 41.47  E-value: 9.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604770  629 ALLGMQLFGGQFnfdegtppTNFDTFPAAIMTVFQILTGeDWNEVMYDgIKSQGGVQGgMVFSIYFIVLTLFGNYTLLNV 708
Cdd:PLN03223 1345 AFIGHVIFGNAS--------VHFSDMTDSINSLFENLLG-DITYFNED-LKNLTGLQF-VVGMIYFYSYNIFVFMILFNF 1413

                          90
                  ....*....|....*...
gi 119604770  709 FLAIAVDNL----ANAQE 722
Cdd:PLN03223 1414 LLAIICDAFgevkANAAE 1431
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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