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Conserved domains on  [gi|119602902|gb|EAW82496|]
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tetracycline transporter-like protein, isoform CRA_a [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 51-432 2.58e-173

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17389:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 391  Bit Score: 491.40  E-value: 2.58e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  51 ESHGRAHDPLYGSWQGG-VDWFATAIGMPVEKRYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVAT 129
Cdd:cd17389   27 DYYGQNDDSGLYSLQISsVDWFRDAIGAPDERRYNSVLFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAI 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 130 SYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASL----------P 199
Cdd:cd17389  107 SYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFasftrslgevF 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 200 LEMAPWFALLFAASDLLFIFCFLPETLPlekrapsialgfrdaadllsplallrfsavargqdppsgdrlSSLRRLGLVY 279
Cdd:cd17389  187 FSMPALFALVLALADLLFIFFFLPETLP------------------------------------------SNLRRLGLVY 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 280 FLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLTMATIQGAYARRIHPGGEVAAVKRALLLLVPAFLLIGWGRSL 359
Cdd:cd17389  225 FLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPGKEKKAVLQGLILLIPAFLLIGWASSV 304

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119602902 360 PVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTVMGTLRSLGALARAAGPLVAASVYWLAGAQACFTTWS 432
Cdd:cd17389  305 TVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLAGSEACYTIGA 377
 
Name Accession Description Interval E-value
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 51-432 2.58e-173

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 491.40  E-value: 2.58e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  51 ESHGRAHDPLYGSWQGG-VDWFATAIGMPVEKRYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVAT 129
Cdd:cd17389   27 DYYGQNDDSGLYSLQISsVDWFRDAIGAPDERRYNSVLFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAI 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 130 SYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASL----------P 199
Cdd:cd17389  107 SYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFasftrslgevF 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 200 LEMAPWFALLFAASDLLFIFCFLPETLPlekrapsialgfrdaadllsplallrfsavargqdppsgdrlSSLRRLGLVY 279
Cdd:cd17389  187 FSMPALFALVLALADLLFIFFFLPETLP------------------------------------------SNLRRLGLVY 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 280 FLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLTMATIQGAYARRIHPGGEVAAVKRALLLLVPAFLLIGWGRSL 359
Cdd:cd17389  225 FLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPGKEKKAVLQGLILLIPAFLLIGWASSV 304

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119602902 360 PVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTVMGTLRSLGALARAAGPLVAASVYWLAGAQACFTTWS 432
Cdd:cd17389  305 TVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLAGSEACYTIGA 377
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
85-410 2.70e-18

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 85.80  E-value: 2.70e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  85 SVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKG-NVSLSTAI 163
Cdd:COG2814   43 SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALAL 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 164 VADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASL----PLEMAPWFALLFAASDLLFIFCFLPETLPLEKRAPSIALgf 239
Cdd:COG2814  123 IADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLadlfGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL-- 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 240 rdaadllspLALLRFSAvargqdppsgdrlssLRRLGLVYFLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLTM 319
Cdd:COG2814  201 ---------RELLRRPR---------------LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGG 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 320 ATIQGAYARRIHPGGEVAAVKRALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTVMGT 399
Cdd:COG2814  257 VLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGL 336

                        330
                 ....*....|.
gi 119602902 400 LRSLGALARAA 410
Cdd:COG2814  337 YNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
85-412 4.93e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 82.08  E-value: 4.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902   85 SVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNV-SLSTAI 163
Cdd:pfam07690  30 SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALfPAALAL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  164 VADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLpLEMAPW---FALLFAASDLLFIFCFLPETLPLEKRAPSIALGFR 240
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL-ASLFGWraaFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  241 DAADLLSPLallrfsavargqdppsgdrLSSLRRLGLVYFLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLTMA 320
Cdd:pfam07690 189 SLIVAWKAL-------------------LRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGA 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  321 TIQ---GAYARRIHPGGEVAAVKRALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTVM 397
Cdd:pfam07690 250 IGRlllGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTAS 329

                         330
                  ....*....|....*
gi 119602902  398 GTLRSLGALARAAGP 412
Cdd:pfam07690 330 GLYNTAGSLGGALGP 344
2_A_01_02 TIGR00880
Multidrug resistance protein;
90-225 7.66e-15

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 71.14  E-value: 7.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902   90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLST-AIVADLG 168
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGaALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119602902  169 SPLARSQGMAVIGVAFSLGFTLGPMLGA----SLPLEMAPWFALLFAASDLLFIFCFLPET 225
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGvlaqFLGWRAPFLFLAILALAAFILLAFLLPET 141
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
96-233 9.96e-07

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 50.68  E-value: 9.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  96 FSVLQFLCAPLtgatSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVS-LSTAIVADLGSPLARS 174
Cdd:PRK11102  39 FAIGQLFYGPM----ADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASvVINALMRDMFPKEEFS 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119602902 175 QGMAVIGVAFSLGFTLGPMLGASLplemAPWFA--------LLFAASDLLFIFCFLPETLPLEKRAP 233
Cdd:PRK11102 115 RMMSFVTLVMTIAPLLAPIIGGWL----LVWFSwhaifwvlALAAILAAALVFFFIPETLPKERRQP 177
 
Name Accession Description Interval E-value
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 51-432 2.58e-173

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 491.40  E-value: 2.58e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  51 ESHGRAHDPLYGSWQGG-VDWFATAIGMPVEKRYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVAT 129
Cdd:cd17389   27 DYYGQNDDSGLYSLQISsVDWFRDAIGAPDERRYNSVLFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAI 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 130 SYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASL----------P 199
Cdd:cd17389  107 SYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFasftrslgevF 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 200 LEMAPWFALLFAASDLLFIFCFLPETLPlekrapsialgfrdaadllsplallrfsavargqdppsgdrlSSLRRLGLVY 279
Cdd:cd17389  187 FSMPALFALVLALADLLFIFFFLPETLP------------------------------------------SNLRRLGLVY 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 280 FLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLTMATIQGAYARRIHPGGEVAAVKRALLLLVPAFLLIGWGRSL 359
Cdd:cd17389  225 FLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPGKEKKAVLQGLILLIPAFLLIGWASSV 304

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119602902 360 PVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTVMGTLRSLGALARAAGPLVAASVYWLAGAQACFTTWS 432
Cdd:cd17389  305 TVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLAGSEACYTIGA 377
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 68-433 1.66e-60

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 200.88  E-value: 1.66e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  68 VDWFATAIGMPV--------EKRYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRS 139
Cdd:cd17330    7 LDALGFGIVFPVlpfyvrefNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRN 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 140 FAAFLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASL----PLEMAPWFALLFAASDL 215
Cdd:cd17330   87 LWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLstpyGYALPFLVAAALALLNL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 216 LFIFCFLPetlplekrapsialgfrdaadllsplallrfsavargqdppsgdrlsSLRRLGLVYFLYLFLFSGLEYTLSF 295
Cdd:cd17330  167 VLVLFFLP-----------------------------------------------PLRRLLLVYFLIALAFAGLESVFSL 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 296 LTHQRFQFSSLQQGKMFFLIGLTMATIQGAYARRIHP-GGEVAAVKRALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAA 374
Cdd:cd17330  200 FLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKrLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTG 279

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 119602902 375 VVVPCLSSVVAGYGSPGQKGTVMGTLRSLGALARAAGPLVAASVYWLAGAQACFTTWSG 433
Cdd:cd17330  280 IVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAG 338
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 90-415 7.13e-26

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 107.70  E-value: 7.13e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGS 169
Cdd:cd17390   34 GLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 170 PLARSQGMAVIGVAFSLGFTLGPMLGASLpLEMAPWFALLFAASDLLFIFCflpetlplekrAPSIALGFRDAADLLspl 249
Cdd:cd17390  114 EQERSRVLGRFNAASSLGFILGPVVGGHL-AETDGGFYYVALLCSAIFILN-----------AGLVWFLLSKLWDLL--- 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 250 aLLRFsavargqdppsgdrlsslrrlglvyflyLFLFSGLEY--TLSFLTHQRFQFSSLQQGKMFFLIGLtMATIQGAYA 327
Cdd:cd17390  179 -LVRF----------------------------LMGFSVLLFrsNFSLYLEERFDLSPKTIGYLISYSGV-LGALSGFLV 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 328 RRI---HPGGEVAAVKRALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTVMGTLRSLG 404
Cdd:cd17390  229 GRIlklYKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVT 308

                        330
                 ....*....|.
gi 119602902 405 ALARAAGPLVA 415
Cdd:cd17390  309 SLARILAPLLS 319
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 47-419 4.98e-24

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 103.10  E-value: 4.98e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  47 PGlleshgrahdpLYGSWQGGVDWFATaigmpvekrynsvlFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMG 126
Cdd:cd17388   23 PT-----------LLREFVGDSADAAT--------------HYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 127 VATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLG---ASLPLEMA 203
Cdd:cd17388   78 AALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGgllGEISPRAP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 204 PWFALLFAASDLLFIFCFLPETLPLEKRAPSialgFRDAADLLSPLALLRfsavargqdppsgdRLSSLRRLGLVYFLYL 283
Cdd:cd17388  158 FLVAAGLNGLNFLLGLFVLPESLPPERRRAF----RWRRANPFGSLRWLT--------------GFPGLLGLLAVFFLIQ 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 284 FLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLTMATIQGAYARRIHPG-GEVAAVKRALLLLVPAFLLIGWGRSLPVL 362
Cdd:cd17388  220 LIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRlGEKRAILLGLAADALGFLLLAFATQGWMV 299

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 119602902 363 GLGLLLYSfAAAVVVPCLSSVVAGYGSPGQKGTVMGTLRSLGALARAAGPLVAASVY 419
Cdd:cd17388  300 FPILILLA-LGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIF 355
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 85-428 2.63e-23

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 100.73  E-value: 2.63e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  85 SVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKG-NVSLSTAI 163
Cdd:cd17325   29 SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAaVWPAAMAL 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 164 VADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAAsdLLFIFCFLPETLPLEKRAPSIALGFRDAA 243
Cdd:cd17325  109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCA--ALALLALVLALLLLPEPRPPPNKRAVSAA 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 244 DLLSPLALLRfsavargqdppsgdRLSSLRRLGLVYFLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLTMATIQ 323
Cdd:cd17325  187 RLRSGLRLLL--------------RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQ 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 324 GAYARRIHPGGEVAAVKRALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTVMGTLRSL 403
Cdd:cd17325  253 PPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTA 332

                        330       340
                 ....*....|....*....|....*
gi 119602902 404 GALARAAGPLVAASVYWLAGAQACF 428
Cdd:cd17325  333 FSLGMVLGPLLGGFLYDAFGFATPF 357
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 90-430 5.14e-23

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 99.95  E-value: 5.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGI-SKGNVSLSTAIVADLG 168
Cdd:cd17474   37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIgAAGLGPLALTLIGDLF 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 169 SPLARSQGMAVIGVAFSLGFTLGPMLGASLplEMAPW---FALLFAASDLLFIFCFLPETLPLEKRAPSIALGFRDAADL 245
Cdd:cd17474  117 EGGERAKAMGLYEAALGLGIAVGPLLGGLL--AAISWrypFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKA 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 246 LSPLALLRFSAVArgqdppsgdrlsslrrlglvyFLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLTMATIQGA 325
Cdd:cd17474  195 LRGRGLLTFLVSA---------------------FLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLF 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 326 YARRIHPG-GEVAAVKRALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTVMGTLRSLG 404
Cdd:cd17474  254 VGRLLKKRfGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVR 333

                        330       340
                 ....*....|....*....|....*.
gi 119602902 405 ALARAAGPLVAASVYWLAGAQACFTT 430
Cdd:cd17474  334 FLGQAVGPLLFGLLLEIFGLSAPFLV 359
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
85-410 2.70e-18

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 85.80  E-value: 2.70e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  85 SVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKG-NVSLSTAI 163
Cdd:COG2814   43 SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALAL 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 164 VADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASL----PLEMAPWFALLFAASDLLFIFCFLPETLPLEKRAPSIALgf 239
Cdd:COG2814  123 IADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLadlfGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL-- 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 240 rdaadllspLALLRFSAvargqdppsgdrlssLRRLGLVYFLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLTM 319
Cdd:COG2814  201 ---------RELLRRPR---------------LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGG 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 320 ATIQGAYARRIHPGGEVAAVKRALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTVMGT 399
Cdd:COG2814  257 VLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGL 336

                        330
                 ....*....|.
gi 119602902 400 LRSLGALARAA 410
Cdd:COG2814  337 YNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
85-412 4.93e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 82.08  E-value: 4.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902   85 SVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNV-SLSTAI 163
Cdd:pfam07690  30 SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALfPAALAL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  164 VADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLpLEMAPW---FALLFAASDLLFIFCFLPETLPLEKRAPSIALGFR 240
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL-ASLFGWraaFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  241 DAADLLSPLallrfsavargqdppsgdrLSSLRRLGLVYFLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLTMA 320
Cdd:pfam07690 189 SLIVAWKAL-------------------LRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGA 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  321 TIQ---GAYARRIHPGGEVAAVKRALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTVM 397
Cdd:pfam07690 250 IGRlllGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTAS 329

                         330
                  ....*....|....*
gi 119602902  398 GTLRSLGALARAAGP 412
Cdd:pfam07690 330 GLYNTAGSLGGALGP 344
2_A_01_02 TIGR00880
Multidrug resistance protein;
90-225 7.66e-15

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 71.14  E-value: 7.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902   90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLST-AIVADLG 168
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGaALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119602902  169 SPLARSQGMAVIGVAFSLGFTLGPMLGA----SLPLEMAPWFALLFAASDLLFIFCFLPET 225
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGvlaqFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 84-426 1.17e-14

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 75.33  E-value: 1.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  84 NSVLFGGLIgSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLiGGISKGNVSLSTAI 163
Cdd:cd17331   33 DSVVFGYLQ-TTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRL-PSVFMHAMQAAQMV 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 164 VADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAAS----DLLFIFCFLPE-TLPLEKRAPSIALG 238
Cdd:cd17331  111 VTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVgsllSIVLVILLIPSnTKSKREKEAKESAS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 239 FRDAADLLSPLALLRFSAVARgqdppsgdrlsslrrLGLVYFLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLT 318
Cdd:cd17331  191 PPSVFNLKEILRLLRLPGVAF---------------LLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVL 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 319 MATIQGAYARR-IHPGGEVAAVKRALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTVM 397
Cdd:cd17331  256 GMVVQGLLVGPlTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTAL 335

                        330       340
                 ....*....|....*....|....*....
gi 119602902 398 GTLRSLGALARAAGPLVAASVYWLAGAQA 426
Cdd:cd17331  336 GLSHALFSLVRTVSPTIGGALLQAYGFPS 364
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 90-425 2.07e-12

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 68.41  E-value: 2.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNV-SLSTAIVADLG 168
Cdd:cd17329   38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFePASEAMIADVT 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 169 SPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMapwFALLFAASDLLFIFCF------LPETLPLEKRAPSialgfrdA 242
Cdd:cd17329  118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS---FRLLFLAAAVLFLLAAlvllflLPETRPKRRAAEK-------T 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 243 ADLLSPLALLRFSAvargqdppsgdrlssLRRLGLVYFLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLTMATI 322
Cdd:cd17329  188 EILRGYKIVLRDRA---------------FLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLL 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 323 QGAYARRIHPGGEVAAVKRALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTVMGTLRS 402
Cdd:cd17329  253 QFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYAL 332

                        330       340
                 ....*....|....*....|...
gi 119602902 403 LGALARAAGPLVAASVYWLAGAQ 425
Cdd:cd17329  333 AWGLGRAIGPLVGGLLLDLLGPG 355
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 95-258 3.57e-12

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 67.60  E-value: 3.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  95 AFSVLQFLCAPLtgatSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVS-LSTAIVADLGSPLAR 173
Cdd:cd17320   46 GFALGQLLYGPL----SDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSvVARAIVRDLYSGAEL 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 174 SQGMAVIGVAFSLGFTLGPMLGASLpLEMAPW---FALLFAASDLLFI--FCFLPETLPLEKRAPSIALGFRDAADLLSP 248
Cdd:cd17320  122 AKIFSLLMMILAIAPALAPLLGGLL-LLFFGWraiFVFLALLGLLLLLlvLLFLPETLPEEKRKPLLSSLLRAYKRVLKN 200

                        170
                 ....*....|
gi 119602902 249 LALLRFSAVA 258
Cdd:cd17320  201 RRFLGYALAL 210
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 90-419 2.38e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 65.14  E-value: 2.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLST-AIVADLG 168
Cdd:cd06174   34 GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVlALIADLF 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 169 SPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAASDLLFIFCFL-----PETLPLEKRAPSIALGFRDAA 243
Cdd:cd06174  114 PERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAIllllvVPDPPESARAKNEEASSKSVL 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 244 DLLSPLALLRfsavargqdppsgdrlsSLRRLGLVYFLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLTMAT-- 321
Cdd:cd06174  194 KLLKRVLKNP-----------------GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALgs 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 322 -IQGAYARRIHPGGEVAAVkrALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTVMGTL 400
Cdd:cd06174  257 lLLGLLSDRLIGRKPLLLI--GLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLL 334

                        330
                 ....*....|....*....
gi 119602902 401 RSLGALARAAGPLVAASVY 419
Cdd:cd06174  335 NTFGFLGGAIGPLLAGFLL 353
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 90-428 5.71e-11

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 63.72  E-value: 5.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNV-SLSTAIVADLG 168
Cdd:cd17324   37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFwAIAAAYAADLV 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 169 SPLARSQGMAVIGVAFSLGFTLGPMLGASLPLE----MAPWFALLFAASDLLFIFCFLPETLPLEKRAPSIALGFRDAAd 244
Cdd:cd17324  117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLlgwrAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLL- 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 245 llsplallrfsavargqdppsgdRLSSLRRLGLVYFLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLTMA---T 321
Cdd:cd17324  196 -----------------------RNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVvgsP 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 322 IQGAYARRIHPGGEVAAvkrALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAAVVVPCLSSVVAgYGSPGQKGTVMGTLR 401
Cdd:cd17324  253 LAGRLADRGGRRALLIA---LLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVL-RLAPEARGLASSLYL 328

                        330       340
                 ....*....|....*....|....*..
gi 119602902 402 SLGALARAAGPLVAASVYWLAGAQACF 428
Cdd:cd17324  329 AAYNLGGALGAALGGLVLDHGGWAGVG 355
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 88-224 6.39e-11

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 63.77  E-value: 6.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  88 FGGLIGSAFSVLQFLCAPLTGATSDCLG--RRPVMLLCLMGVAT----SYAVWATSRSFAAFLASRLIGGISKGNVSLST 161
Cdd:cd17326   37 FFGWVVAAYSLGQLVFSPVFGYWSNKTSsvKEPLIVSILIAIVGnilyALAEYFPSNRKYVMLVARFLIGVGAGNVAVLR 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 162 AIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGA--------------SLPLEM--AP-WFALLFAASDLLFIFCFLPE 224
Cdd:cd17326  117 AYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAaftpigypgyvigiKLRFNMytAPaWLMAILGIINIILILFFFKE 196
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 84-421 1.56e-09

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 59.74  E-value: 1.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  84 NSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLClmgVATSYAVWATSR-SFAAFLASRLIGGISKGNVSLSTA 162
Cdd:cd17387   33 HTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLT---VFFTCAPIPLMRiSPWWYFAMISVSGIFSVTFSVIFA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 163 IVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLpleMAPW-------FALLFAASDLLFIFCFLPETLPLEKRAPSi 235
Cdd:cd17387  110 YVADITTEEERSTAYGLVSATFAASLVTSPALGAYL---SESYgdnlvvlVATIVALLDICFILLAVPESLPEKMRPAS- 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 236 aLGFRDAADLLSPLALLRFSavarGQDPpsgdrlsSLRRLGLVYFLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLI 315
Cdd:cd17387  186 -WGAPISWEQADPFASLRKV----GKDK-------TVLLICITVFLSYLPEAGQYSSFFVYLKQVMGFEYEEVAAFIAVV 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 316 GLTMATIQGAYA----RRIhpgGEVAAVKRALLLLVPAFLLIGWGrSLPVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPG 391
Cdd:cd17387  254 GILSITAQTLLLsilmRSI---GAKNTILLGLGFQMLQLAWYGFG-SQHWMMWAAGAVAAMSSITFPAISALVSRYADPD 329

                        330       340       350
                 ....*....|....*....|....*....|
gi 119602902 392 QKGTVMGTLRSLGALARAAGPLVAASVYWL 421
Cdd:cd17387  330 QQGAVQGMITGIRGLCNGLGPALFGFVFYL 359
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 84-428 4.01e-08

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 54.93  E-value: 4.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  84 NSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLC--LMGVATSYAVWATSRSFAA----FLASRLIGGISKGNV 157
Cdd:cd06173   31 GSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdlLRALLAAVLALLALLGSLSlwllLVLAFLLGIASAFFG 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 158 SLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAAsdLLFIFCFLPE-TLPLEKRAPSIA 236
Cdd:cd06173  111 PARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA--LSFLLSALLLlFIRRPPPAAPGE 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 237 LGFRDAADLLSPLALLRFSAVargqdppsgdrlssLRRLGLVYFLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIG 316
Cdd:cd06173  189 SSSLLLRDLREGLRYLRRSPL--------------LRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFG 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 317 LTMATIQGAYARRIHPGGEVAAVKRALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTV 396
Cdd:cd06173  255 VGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRV 334

                        330       340       350
                 ....*....|....*....|....*....|..
gi 119602902 397 MGTLRSLGALARAAGPLVAASVYWLAGAQACF 428
Cdd:cd06173  335 FSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 96-231 1.88e-07

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 53.16  E-value: 1.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902   96 FSVLQFLCAPLtgatSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIG--GISKGNVsLSTAIVADLGSPLAR 173
Cdd:TIGR00710  53 FAAGQLLWGPL----SDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQafGASAGSV-ISQALVRDIYPGEEL 127

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119602902  174 SQGMAVIGVAFSLGFTLGPMLGASLpLEMAPW---FALLFAASDLL--FIFCFLPETLPLEKR 231
Cdd:TIGR00710 128 SRIYSILMPVLALAPAVAPLLGGYI-LVWLSWhaiFAFLSLAGILLsaLIFFILPETLPYEAR 189
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
90-242 3.18e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 52.16  E-value: 3.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGIskGNVSLSTAI---VAD 166
Cdd:COG0738   46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGL--GLGLLDVAAnpyVAA 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 167 LGsPLARSQGMAVIGVAFSLGFTLGPMLGASLPL--------EMAPWFALLFAASDLLFIFCFLPETLPLEKRAPSIALG 238
Cdd:COG0738  124 LG-PETAASRLNLLHAFFSLGALLGPLLGGLLILlglslswhLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAAS 202


                 ....
gi 119602902 239 FRDA 242
Cdd:COG0738  203 LKSL 206
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
90-223 3.60e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 52.18  E-value: 3.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKG-NVSLSTAIVADLG 168
Cdd:COG2271   48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWF 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 119602902 169 SPLARSQGMAVIGVAFSLGFTLGPMLGASLpLEMAPWFALLFAASDLLFIFCFLP 223
Cdd:COG2271  128 PPKERGRALGIFNAGGPLGGALAPPLLGWL-LAAFGWRAAFLILGLPGLLLALLR 181
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 89-212 3.76e-07

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 52.24  E-value: 3.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  89 GGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVS-LSTAIVADL 167
Cdd:cd17328   36 AGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSpIAPTIIADL 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 119602902 168 GSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPW-FALLFAA 212
Cdd:cd17328  116 FPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWrWAFRVTG 161
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
96-233 9.96e-07

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 50.68  E-value: 9.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  96 FSVLQFLCAPLtgatSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVS-LSTAIVADLGSPLARS 174
Cdd:PRK11102  39 FAIGQLFYGPM----ADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASvVINALMRDMFPKEEFS 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119602902 175 QGMAVIGVAFSLGFTLGPMLGASLplemAPWFA--------LLFAASDLLFIFCFLPETLPLEKRAP 233
Cdd:PRK11102 115 RMMSFVTLVMTIAPLLAPIIGGWL----LVWFSwhaifwvlALAAILAAALVFFFIPETLPKERRQP 177
emrD PRK11652
multidrug transporter EmrD;
95-240 1.15e-06

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 50.68  E-value: 1.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  95 AFSVLQFLCAPLtgatSDCLGRRPVML--LCLMGVATSYAVWATSrsFAAFLASRLIGGISKGNV-SLSTAIVADL--GS 169
Cdd:PRK11652  55 TYGLSQLFYGPL----SDRVGRRPVILvgMSIFILGTLVALFAHS--LTVLIAASAIQGLGTGVGgVMARTLPRDLyeGT 128

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119602902 170 PLARSQGMAVIGVAFS--LGFTLGPMLGASLPLEMAPWFALLFAASDLLFIFCFLPETLPLEKRAPSIALGFR 240
Cdd:PRK11652 129 QLRHANSLLNMGILVSplLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPETRPADARRTRVLASYR 201
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 72-252 1.66e-06

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 49.86  E-value: 1.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  72 ATAIGMPVEKRYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGG 151
Cdd:cd17477   16 LPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMG 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 152 ISKGNVSLST-AIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAASDL-LFIFCFLPETLPLE 229
Cdd:cd17477   96 IGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLLaLVPLLLTRRAAPEI 175

                        170       180
                 ....*....|....*....|...
gi 119602902 230 KRAPSIALGfrdAADLLSPLALL 252
Cdd:cd17477  176 EEAESISLR---RLLRIAPLALL 195
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 91-226 1.80e-06

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 49.88  E-value: 1.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  91 LIGSAFSVLQFlcAPLtgatSDCLGRRPVMLLCLM-GVATSYAVwATSRSFAAFLASRLIGGISKGNV-SLSTAIVADLG 168
Cdd:cd17323   44 VLGFGLGPLIW--APL----SELYGRRPVYLVSLFiFVIFQIGC-ALAPNIAMLIILRFLQGFFGSSPlAIGAGTIADLF 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119602902 169 SPLARSQGMAVIGVAFSLGFTLGPMLGA----SLPLEMAPWFALLFAASDLLFIFCFLPETL 226
Cdd:cd17323  117 TPEERGKAMGVYSLGPLLGPALGPIIGGfitqSLGWRWIFWFLAIISGFCLILIFLFLPIVL 178
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 90-234 2.34e-06

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 49.93  E-value: 2.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLL-CLMGVATSyAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLG 168
Cdd:cd06179   35 TWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGgNLLGVVGS-IVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELV 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119602902 169 SPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAP-W------FALLFAASDLLFIFCFLPETLPLEKRAPS 234
Cdd:cd06179  114 PNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAgWrwifyiNAIFNALALILLFFFYHPPPRPQLHGSST 186
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 90-259 3.90e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 48.71  E-value: 3.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGS 169
Cdd:cd17478   34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAA 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 170 PLARSQGMAVIGVAFSLGFTLGPMLGASLP-----LEMAPWFALLFAASdLLFIFCFLPETLPLEKRAPSIALGFRDAAD 244
Cdd:cd17478  114 GGRRGLAMSIFSVGGNLGFALGPLIAAALValfggLGLLILLIIPGLAV-ALLLLRLRPLKKPEAKKAAAKSSARSTLKG 192

                        170
                 ....*....|....*
gi 119602902 245 LLSPLALLRFSAVAR 259
Cdd:cd17478  193 VWRALLLLLIIVFLR 207
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 102-423 1.46e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 47.18  E-value: 1.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 102 LCAPLTGATSDCLGRRPVMLLCL--MGVATSYAVWATsrSFAAFLASRLIGGISKGNV-SLSTAIVADLGSPLARSQGMA 178
Cdd:cd17473   50 LFAPLAGWLADRFGRKRLLIAGLllYGIGGVAGLFLD--SLYALLASRALLGIGVAGImTLATALIGDYFEGEERAKMLG 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 179 VIGVAFSLGFTLGPMLGASLpLEM---APWFALLFAASDLLFIFCFLPETLPLEKRAPSIalgfrdAADLLSPLALLRFS 255
Cdd:cd17473  128 LQSAAMSLGGVVFLLLGGAL-AEIgwrAPFLVYLLALPVLILVLLFLPEPARKSKSAASP------GAATAAALPWKRVL 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 256 AVArgqdppsgdrlsslrrlgLVYFLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLTMATIQGAYARRIHPGGE 335
Cdd:cd17473  201 PIY------------------FLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGK 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 336 VAAVKRALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTVMGTLRSLGALARAAGPLVA 415
Cdd:cd17473  263 RRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVL 342


                 ....*...
gi 119602902 416 ASVYWLAG 423
Cdd:cd17473  343 GPLVNLTG 350
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
91-247 2.84e-05

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 46.09  E-value: 2.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  91 LIGSAFsvLQFLCAPLtgatSDCLGRRPVML--LCLMGVATSYAVWAtsRSFAAFLASRLIGGISK---GNVSLS----- 160
Cdd:PRK15402  58 LAGGMF--LQWLLGPL----SDRIGRRPVMLagVAFFILTCLAILLA--QSIEQFTLLRFLQGIGLcfiGAVGYAaiqes 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 161 ---------TAIVAD--LGSPLarsqgmavigvafslgftLGPMLGASLpLEMAPW------FALLfAASDLLFIFCFLP 223
Cdd:PRK15402 130 feeadaikiTALMANvaLLAPL------------------LGPLVGAAL-IHVLPWrgmfvlFAAL-AALSFFGLWRAMP 189

                        170       180
                 ....*....|....*....|....
gi 119602902 224 ETLPLEKRAPSIALGFRDAADLLS 247
Cdd:PRK15402 190 ETAGRVGEKLSLKELGRDYKLVLK 213
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 104-227 3.97e-05

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 45.36  E-value: 3.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 104 APLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIvadLGSPLARSQGMAVIGVA 183
Cdd:cd17374   52 ALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLI---LGTEWTTPRHRALAITL 128

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 119602902 184 FSLGFTLGPMLGASLPLEMAPWFALLFAASDLLFIFCFLPETLP 227
Cdd:cd17374  129 TSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLYSWWLP 172
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 108-222 5.59e-05

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 45.10  E-value: 5.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 108 GATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGSPlarSQGMAVIGVAFSLG 187
Cdd:cd17446   54 GGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMP---TRVRAVVGTLLGYC 130

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 119602902 188 FTLGPMLGASLPLEMAPWFALLFAASdLLFIFCFL 222
Cdd:cd17446  131 YTLGQLILAGVAYAIRDWRWLQLAVS-LPFFIFFL 164
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 88-222 7.54e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 44.49  E-value: 7.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  88 FGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLC-----LMGVATSYavwatSRSFAAFLASRLIGGISKGNVSLST- 161
Cdd:cd17317   26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGlvlqiVCGVLSAF-----SPSYELFLVLRFLVGVTSAGIFTVGf 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119602902 162 AIVADLGSPLARSqgmaVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAASDLLFIFCFL 222
Cdd:cd17317  101 VLGMEIVGPKYRS----FVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLL 157
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 90-195 7.97e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 44.48  E-value: 7.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNV-SLSTAIVADLG 168
Cdd:cd17502   33 SWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLmSLAFIIIADLV 112

                         90       100
                 ....*....|....*....|....*..
gi 119602902 169 SPLARSQGMAVIGVAFSLGFTLGPMLG 195
Cdd:cd17502  113 PPRERGKYQGYIGAVFGIASVAGPLIG 139
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 85-228 1.03e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 44.49  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  85 SVLFGGLIGSAFSvlqflcapltGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAI- 163
Cdd:cd17315   42 SLLLGAAIGSLFG----------GPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLy 111

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 164 VADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAAS---DLLFIFC--FLPETLPL 228
Cdd:cd17315  112 ISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWRLMFALAavpALLQLLLmfFLPESRAL 181
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 105-195 1.94e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 43.33  E-value: 1.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 105 PLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGN-VSLSTAIVADLGSPLARSQGMAVIGVA 183
Cdd:cd17503   49 PLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVlIPLAQTILLRIYPPEKRGAAMGLVGLV 128

                         90
                 ....*....|..
gi 119602902 184 FSLGFTLGPMLG 195
Cdd:cd17503  129 ILLAPAIGPTLG 140
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 102-222 6.46e-04

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 41.88  E-value: 6.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 102 LCAPLTGATSDCLGRRPVMLLCLMGVATSY------AVWATSRSFAAFLASRLIGGISKGNVSLSTAI---VADLGSPLA 172
Cdd:cd17386   45 FSSLFLGSWSDRYGRKPPLLMSLVGLLLSSlilvliVYFTTVPSVWWFYLSAIPLALFGGFTAFLSASfayISDISSEKK 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 119602902 173 RSQGMAVIGVAFSLGFTLGPMLG----ASLPLEMAPWFALLFAASDLLFIFCFL 222
Cdd:cd17386  125 RTYRMAILEVALGLGGFLGSLLSghlfKALGYAWSFSISAALLLIALLYILFFL 178
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
60-198 6.78e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.78  E-value: 6.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  60 LYGSWQGGVDWFATAIgmpVEKRYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRR---PVMLLCLMGVATSYAVWAT 136
Cdd:COG2271  192 VYFALYGFLTWLPTYL---VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrklVLAIGLLLAALALLLLALL 268

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119602902 137 SRSFAAFLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASL 198
Cdd:COG2271  269 PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL 330
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 85-225 7.01e-04

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 41.78  E-value: 7.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  85 SVLFGGLIGSAFSvlqflcapltGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVS-LSTAI 163
Cdd:cd17359   44 SALLGAAIGALFA----------GRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASaLVPMY 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119602902 164 VADL------GSPLARSQGMAVIG--VAFSLGFTLGPMLGASLPLEMA----PWFALLFAASdLLFIFCFLPET 225
Cdd:cd17359  114 IAEVapaeirGRLVSLNQLMIVFGqlLAYIVNYLIANAGGADWLGAEGwrwmLGLEAIPAIL-FLLGMLFIPES 186
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 90-225 8.04e-04

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 41.48  E-value: 8.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLC--LMGVATSYAVWATS-RSFAAFLASRLIGGISKGnvsLSTAIVAD 166
Cdd:cd17357   52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISnaLLVVSSLLMFLSKSaKSPELLIFGRFLVGIACG---LSTGFVPM 128

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119602902 167 LGSPLARSQGMAVIGVAFSLGFTLGPMLGA--SLPLEMAP---WFALLFA----ASDLLFIFCFLPET 225
Cdd:cd17357  129 YLQEISPSELRGALGSLTQIGVTLGILLGQvfGLPSVLGTetlWPYLLFFpgipALLQLAALPFFPES 196
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
 89-232 1.16e-03

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 40.95  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  89 GGLIGSAFSVLqflcapLTGATSDCLGRRPVMLLCLMGVATSYAVWAT----SRSFAAFLASRLIGGISkGNVSL----S 160
Cdd:cd17449   73 GGFLVGLFSVT------LLGPWSDSVGRRPVLILPSLGLALQAAVYLLvmylQLHVAYFLIGRILSGLL-GDFNGilagC 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 161 TAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASL--------PLEMApwFALLFAASdlLFIFCFLPETLPLEKRA 232
Cdd:cd17449  146 FAYVADVSDRRSRTFRVAVLEACLGLAGMLASIIGGQWrkaqgyinPFWLV--LALNLAAA--LYAAFCVGESVKEPKSA 221
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 43-252 1.42e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 40.66  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  43 LpllpglleshgrAHDPLYGSWQGGVDWFAtaigmpvekrynsvlfgGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLL 122
Cdd:cd17489   16 L------------PVLPLYAHDLGGSEAVA-----------------GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLI 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 123 CLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLST-AIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASL-PL 200
Cdd:cd17489   67 GLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAaTLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLyQH 146

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 119602902 201 EMAPWFALLFAASDLLFIFCFLPETLPLEKRAPSIALGFRDAADLLSPLALL 252
Cdd:cd17489  147 LGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLP 198
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 116-222 1.81e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 40.22  E-value: 1.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 116 RRPVMLLCLMGVATSYAVWATSRSFAAFLA-SRLIGGISKGNVSLSTAI---VADLGSPLARSQGMAVIGVAFSLGFTLG 191
Cdd:cd17471   62 RKPLILLALLAGALGYLLFAFLRNYWVLLLvGVVLLSLGAAAFPQLFALareYADRSSGRDATLFNSVLRAAFSLAWVIG 141

                         90       100       110
                 ....*....|....*....|....*....|..
gi 119602902 192 PMLGASLpleMAPW-FALLFAASDLLFIFCFL 222
Cdd:cd17471  142 PPLAFLL---LDVLgFTGLFLLAALLYLVVAL 170
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 71-219 2.34e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.85  E-value: 2.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  71 FATAIGMPVEKrynsvlfGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLC--LMGVATSYAVWATSRSFAAFLASRL 148
Cdd:cd17477  214 YGLRLGLSVAQ-------AALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCalLGALAALLLPLVPGLPLALLVLLFL 286

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119602902 149 IGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAP-WFALLFAASDLLFIF 219
Cdd:cd17477  287 WGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPhGLFLFLAAVALLFLL 358
Sugar_tr pfam00083
Sugar (and other) transporter;
90-225 2.92e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 39.95  E-value: 2.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902   90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLC--LMGVATSYAVWATS-RSFAAFLASRLIGGISKGNVS-LSTAIVA 165
Cdd:pfam00083  49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIAnvLFVIGAVLQGAAKGkWSVYQLIVGRVLVGIGVGGASvLAPMYIS 128

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119602902  166 DLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPW-----FALLFAASDLLFIF-CFLPET 225
Cdd:pfam00083 129 EIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNSDgwripLGLQLVPALLLIIGlLFLPES 194
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 104-196 3.06e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 39.48  E-value: 3.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 104 APLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVA 183
Cdd:cd17504   48 TPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSAT 127

                         90
                 ....*....|...
gi 119602902 184 FSLGFTLGPMLGA 196
Cdd:cd17504  128 FGIGAGIGLPLGG 140
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 103-198 4.09e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.08  E-value: 4.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 103 CAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGN-VSLSTAIVADLGSPLARSQGMAVIG 181
Cdd:cd17321   47 LLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAiMPASLALIAATFPGERRGRALGLWG 126

                         90
                 ....*....|....*..
gi 119602902 182 VAFSLGFTLGPMLGASL 198
Cdd:cd17321  127 AVVGIGAALGPLLGGLL 143
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 90-195 5.55e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 38.73  E-value: 5.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSL-STAIVADLG 168
Cdd:cd17489  230 GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPaLQALAVDLV 309

                         90       100
                 ....*....|....*....|....*..
gi 119602902 169 SPLARSQGMAVIGVAFSLGFTLGPMLG 195
Cdd:cd17489  310 PPHRRGAANGTFFIFFDLGIGLGGLLL 336
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 93-225 6.20e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 38.71  E-value: 6.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  93 GSAFSVLQFLCAPLTGATS----DCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAI-VADL 167
Cdd:cd17358   43 FSWFGSLLTLGALIGALLSgklaDRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVyIAEI 122

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119602902 168 GSPLARS------QGMAVIGVafSLGFTLGPMLgaslplemaPWFALLFAASDLLFIF----CFLPET 225
Cdd:cd17358  123 APKNVRGalgslnQLLVNIGI--LLGYVLGSFL---------PWRTLALIGAIPPVVFlillFFIPES 179
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 72-201 6.59e-03

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 38.88  E-value: 6.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902   72 ATAIGMP-----VEKRYNSVLFGGL--IGSAFSVLqflcapLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFL 144
Cdd:pfam06609  62 ASASALPnilqdIGQSENQGLFSTLwtMGQAVSIL------MMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLL 135

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 119602902  145 ASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLE 201
Cdd:pfam06609 136 AAMTLLGVAAGPAGASPLFIGELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQ 192
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 82-219 6.76e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 38.69  E-value: 6.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  82 RYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLST 161
Cdd:cd17478  225 RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTV 304

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119602902 162 AIVADLgspLARSQGMA---VIGVAFSLGFTLGPMLGA---SLPLEMAPWFALLFAASDLLFIF 219
Cdd:cd17478  305 VLAQEL---LPGNVGLAsglMMGLSFGLGGIGAPVLGAladAFGLESVLLILALLPLLGALLAF 365
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 85-222 6.77e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 38.56  E-value: 6.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  85 SVLFGGLIGSAFSVLQFLCAPLTGATSD-CLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVS-LSTA 162
Cdd:cd06174  237 SVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLpLSFA 316

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902 163 IVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAASDLLFIFCFL 222
Cdd:cd06174  317 LIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 85-212 7.45e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 38.29  E-value: 7.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  85 SVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNV-SLSTAI 163
Cdd:cd17370  232 SAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQeSIERAA 311

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 119602902 164 VADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAA 212
Cdd:cd17370  312 VADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSA 360
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 83-219 7.54e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 38.30  E-value: 7.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119602902  83 YNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRS-FAAFLASRLIGGISKGNVSLST 161
Cdd:cd17324  230 GFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSpLLLLVGLVLWGLGFFAAHSALQ 309

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119602902 162 AIVADLgSPLARSQGMAVIGVAFSLGFTLGPMLG----ASLPLEMAPWFALLFAASDLLFIF 219
Cdd:cd17324  310 TRVLRL-APEARGLASSLYLAAYNLGGALGAALGglvlDHGGWAGVGWVGAALLLLALLLAL 370
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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