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Conserved domains on  [gi|119601842|gb|EAW81436|]
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tetratricopeptide repeat domain 7B, isoform CRA_d [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TTC7_N pfam19440
Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a ...
 1-366 0e+00

Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a protein that forms the regulatory subunit of the PI4KIIIalpha complex (also known as PI4KA). This complex is composed of PI4KIIIalpha, TTC7 and FAM126A and catalyzes the first step in plasma membrane phosphoinositide synthesis. This TTC7 N-terminal domain contains basic residues suitable for interaction with the acidic inner leaflet of the plasma membrane and is required for localising the active site near its substrate. TTC7 acts as a bridge between PI4KA and EFR3B-FAM126A, via direct interactions. ERF3B is not part of the complex but contributes to its recruitment to the membrane.


:

Pssm-ID: 466084  Cd Length: 386  Bit Score: 627.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842    1 MAELLLGESKLEQYLKEHPLRQGASPRGPKPQLTEVRKHLTAALDRGNLKSEFLQESNLIMAKLNYVEGDYKEALNIYAR 80
Cdd:pfam19440  45 MANLLLGEGKLEQYLKENPPILENSTEKNQPKLSEAKKHLTSALDRGNLKPEFLQEAHLLLAKLNYVEGDYREALNMYAR 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842   81 VGLDDLPLTAVPPYRLRVIAEAYATKGLCLEKLPISSSTSNLHVDREQDVITCYEKAGDIALLYLQEIERvILSNIQNRS 160
Cdd:pfam19440 125 AGLDDLTLKELPVYRLRLLAEAYAIKGLCLEKQAVSSSSRVRLAEREEEMITCYEKAGDIALLYLQELER-INSNTQNRS 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  161 PKPGPAPHDQELGFFLETGLQRAHVLYFKNGgtdgnikeprmwfrvieqdetrNLTRGVGRFRELLRAVETRTTQNLRMT 240
Cdd:pfam19440 204 PKPGPPSQEQELGFFLETALQRAYVLYFKKG----------------------NLARGVGRYREILRAVETRTTQNLRMT 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  241 IARQLAEILLRGMCEQSYWNPLEDPPCQSPLDDPLrKGANTKTYTLTRRARVYSGENIFCPQENTEEALLLLLISESMAN 320
Cdd:pfam19440 262 IARQLAEVLLRGVCEQSYWNPLEDPPPQSLLDEPL-KGTNTKNYTPSRKPRVYSGENIFCPQDNVEEALLLLLISESMAN 340

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 119601842  321 RDAVLSRIPEHKSDRLISLQSASVVYDLLTIALGRRGQYEMLSECL 366
Cdd:pfam19440 341 RDAVLSRSPEHREARIISLQNATAVYDLLTIAMGRRGQYEMLSECL 386
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
692-825 4.86e-20

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 90.45  E-value: 4.86e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 692 LAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALIL 771
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 119601842 772 HQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELE 825
Cdd:COG0457   87 QALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELD 140
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 351-591 3.61e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 64.75  E-value: 3.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 351 IALG----RRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLH 426
Cdd:COG2956   46 LALGnlyrRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGD 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 427 WlEEAEKFAKTVVDVGEKTSEFkakgYLALGLTYSLQATDAslrgmqevlqrKALLAFQRAHSLSPTDHQAAFYLALQLA 506
Cdd:COG2956  126 W-EKAIEVLERLLKLGPENAHA----YCELAELYLEQGDYD-----------EAIEALEKALKLDPDCARALLLLAELYL 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 507 ISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENfILLFSKVKLQSLCRGPDEALLTC 586
Cdd:COG2956  190 EQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSD-DLLLALADLLERKEGLEAALALL 268


                 ....*
gi 119601842 587 KHMLQ 591
Cdd:COG2956  269 ERQLR 273
 
Name Accession Description Interval E-value
TTC7_N pfam19440
Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a ...
 1-366 0e+00

Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a protein that forms the regulatory subunit of the PI4KIIIalpha complex (also known as PI4KA). This complex is composed of PI4KIIIalpha, TTC7 and FAM126A and catalyzes the first step in plasma membrane phosphoinositide synthesis. This TTC7 N-terminal domain contains basic residues suitable for interaction with the acidic inner leaflet of the plasma membrane and is required for localising the active site near its substrate. TTC7 acts as a bridge between PI4KA and EFR3B-FAM126A, via direct interactions. ERF3B is not part of the complex but contributes to its recruitment to the membrane.


Pssm-ID: 466084  Cd Length: 386  Bit Score: 627.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842    1 MAELLLGESKLEQYLKEHPLRQGASPRGPKPQLTEVRKHLTAALDRGNLKSEFLQESNLIMAKLNYVEGDYKEALNIYAR 80
Cdd:pfam19440  45 MANLLLGEGKLEQYLKENPPILENSTEKNQPKLSEAKKHLTSALDRGNLKPEFLQEAHLLLAKLNYVEGDYREALNMYAR 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842   81 VGLDDLPLTAVPPYRLRVIAEAYATKGLCLEKLPISSSTSNLHVDREQDVITCYEKAGDIALLYLQEIERvILSNIQNRS 160
Cdd:pfam19440 125 AGLDDLTLKELPVYRLRLLAEAYAIKGLCLEKQAVSSSSRVRLAEREEEMITCYEKAGDIALLYLQELER-INSNTQNRS 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  161 PKPGPAPHDQELGFFLETGLQRAHVLYFKNGgtdgnikeprmwfrvieqdetrNLTRGVGRFRELLRAVETRTTQNLRMT 240
Cdd:pfam19440 204 PKPGPPSQEQELGFFLETALQRAYVLYFKKG----------------------NLARGVGRYREILRAVETRTTQNLRMT 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  241 IARQLAEILLRGMCEQSYWNPLEDPPCQSPLDDPLrKGANTKTYTLTRRARVYSGENIFCPQENTEEALLLLLISESMAN 320
Cdd:pfam19440 262 IARQLAEVLLRGVCEQSYWNPLEDPPPQSLLDEPL-KGTNTKNYTPSRKPRVYSGENIFCPQDNVEEALLLLLISESMAN 340

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 119601842  321 RDAVLSRIPEHKSDRLISLQSASVVYDLLTIALGRRGQYEMLSECL 366
Cdd:pfam19440 341 RDAVLSRSPEHREARIISLQNATAVYDLLTIAMGRRGQYEMLSECL 386
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
692-825 4.86e-20

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 90.45  E-value: 4.86e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 692 LAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALIL 771
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 119601842 772 HQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELE 825
Cdd:COG0457   87 QALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELD 140
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 351-591 3.61e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 64.75  E-value: 3.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 351 IALG----RRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLH 426
Cdd:COG2956   46 LALGnlyrRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGD 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 427 WlEEAEKFAKTVVDVGEKTSEFkakgYLALGLTYSLQATDAslrgmqevlqrKALLAFQRAHSLSPTDHQAAFYLALQLA 506
Cdd:COG2956  126 W-EKAIEVLERLLKLGPENAHA----YCELAELYLEQGDYD-----------EAIEALEKALKLDPDCARALLLLAELYL 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 507 ISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENfILLFSKVKLQSLCRGPDEALLTC 586
Cdd:COG2956  190 EQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSD-DLLLALADLLERKEGLEAALALL 268


                 ....*
gi 119601842 587 KHMLQ 591
Cdd:COG2956  269 ERQLR 273
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 323-831 1.91e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 61.25  E-value: 1.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  323 AVLSRIPEHksdrLISLQSASvvydlltIALGRRGQYEMLSECLERAMKfAFEEFHLWYQF-ALSLMAAGKSARAVKVLK 401
Cdd:TIGR02917 286 DALKSAPEY----LPALLLAG-------ASEYQLGNLEQAYQYLNQILK-YAPNSHQARRLlASIQLRLGRVDEAIATLS 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  402 ECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKtvvdVGEKTSEFKAKgYLALGLTYSLQATdaslrgmqevlQRKAL 481
Cdd:TIGR02917 354 PALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAK----ATELDPENAAA-RTQLGISKLSQGD-----------PSEAI 417

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  482 LAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPE 561
Cdd:TIGR02917 418 ADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPD 497

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  562 NFILLFSKVKLQSLCRGPDEALLTCKHMLQIwkscynltNPSDSG---RGSSLLDRTIADRRQLNTITLPDFSDPETGNs 638
Cdd:TIGR02917 498 FFPAAANLARIDIQEGNPDDAIQRFEKVLTI--------DPKNLRailALAGLYLRTGNEEEAVAWLEKAAELNPQEIE- 568

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  639 peayfhgfPSLFSVSSVhatsVAASRVEQALsEVASSLQSSAPKQgplhpwmtlAQIWLHAAEVYIGIGKPAEATACTQE 718
Cdd:TIGR02917 569 --------PALALAQYY----LGKGQLKKAL-AILNEAADAAPDS---------PEAWLMLGRAQLAAGDLNKAVSSFKK 626

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  719 AANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVW 798
Cdd:TIGR02917 627 LLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGF 706

                         490       500       510
                  ....*....|....*....|....*....|...
gi 119601842  799 NGLGEVLQAQGNDAAATECFLTALELEASSPAV 831
Cdd:TIGR02917 707 ELEGDLYLRQKDYPAAIQAYRKALKRAPSSQNA 739
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 693-833 2.43e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 61.25  E-value: 2.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  693 AQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELR-GSMDEARRWYEEALAISPTHVKSMQRLALIL 771
Cdd:TIGR02917  90 NQVLPLLARAYLLQGKFQQVLDELPGKTLLDDEGAAELLALRGLAYLGlGQLELAQKSYEQALAIDPRSLYAKLGLAQLA 169

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119601842  772 HQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAVPF 833
Cdd:TIGR02917 170 LAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLL 231
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 306-413 1.76e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.64  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 306 EEALLLLLISESMANRDAVLSRIPEHKSDRLISLQSASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFAL 385
Cdd:COG5010   17 LTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLAL 96

                         90       100
                 ....*....|....*....|....*...
gi 119601842 386 SLMAAGKSARAVKVLKECIRLKPDDATI 413
Cdd:COG5010   97 LYSRSGDKDEAKEYYEKALALSPDNPNA 124
PRK12370 PRK12370
HilA/EilA family virulence transcriptional regulator;
395-525 9.75e-04

HilA/EilA family virulence transcriptional regulator;


Pssm-ID: 237080 [Multi-domain]  Cd Length: 553  Bit Score: 42.53  E-value: 9.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 395 RAVKVLKECIRLKPDDaTIPLLAAKLCMGSLHWL--EEAEKFAKTVVDVGEKTSEFKAKGYLALGLTyslqATDASLRGM 472
Cdd:PRK12370 279 QALKLLTQCVNMSPNS-IAPYCALAECYLSMAQMgiFDKQNAMIKAKEHAIKATELDHNNPQALGLL----GLINTIHSE 353

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 119601842 473 QEVlqrkALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQ 525
Cdd:PRK12370 354 YIV----GSLLFKQANLLSPISADIKYYYGWNLFMAGQLEEALQTINECLKLD 402
TPR_12 pfam13424
Tetratricopeptide repeat;
766-824 1.79e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 37.75  E-value: 1.79e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119601842  766 RLALILHQLGRYSLAEKILRDAVQVNSTAH--------EVWNGLGEVLQAQGNDAAATECFLTALEL 824
Cdd:pfam13424   8 NLAAVLRRLGRYDEALELLEKALEIARRLLgpdhpltaTTLLNLGRLYLELGRYEEALELLERALAL 74
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 767-833 4.43e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 39.92  E-value: 4.43e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119601842 767 LALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAVPF 833
Cdd:cd24142    6 KAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGYEKY 72
 
Name Accession Description Interval E-value
TTC7_N pfam19440
Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a ...
 1-366 0e+00

Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a protein that forms the regulatory subunit of the PI4KIIIalpha complex (also known as PI4KA). This complex is composed of PI4KIIIalpha, TTC7 and FAM126A and catalyzes the first step in plasma membrane phosphoinositide synthesis. This TTC7 N-terminal domain contains basic residues suitable for interaction with the acidic inner leaflet of the plasma membrane and is required for localising the active site near its substrate. TTC7 acts as a bridge between PI4KA and EFR3B-FAM126A, via direct interactions. ERF3B is not part of the complex but contributes to its recruitment to the membrane.


Pssm-ID: 466084  Cd Length: 386  Bit Score: 627.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842    1 MAELLLGESKLEQYLKEHPLRQGASPRGPKPQLTEVRKHLTAALDRGNLKSEFLQESNLIMAKLNYVEGDYKEALNIYAR 80
Cdd:pfam19440  45 MANLLLGEGKLEQYLKENPPILENSTEKNQPKLSEAKKHLTSALDRGNLKPEFLQEAHLLLAKLNYVEGDYREALNMYAR 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842   81 VGLDDLPLTAVPPYRLRVIAEAYATKGLCLEKLPISSSTSNLHVDREQDVITCYEKAGDIALLYLQEIERvILSNIQNRS 160
Cdd:pfam19440 125 AGLDDLTLKELPVYRLRLLAEAYAIKGLCLEKQAVSSSSRVRLAEREEEMITCYEKAGDIALLYLQELER-INSNTQNRS 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  161 PKPGPAPHDQELGFFLETGLQRAHVLYFKNGgtdgnikeprmwfrvieqdetrNLTRGVGRFRELLRAVETRTTQNLRMT 240
Cdd:pfam19440 204 PKPGPPSQEQELGFFLETALQRAYVLYFKKG----------------------NLARGVGRYREILRAVETRTTQNLRMT 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  241 IARQLAEILLRGMCEQSYWNPLEDPPCQSPLDDPLrKGANTKTYTLTRRARVYSGENIFCPQENTEEALLLLLISESMAN 320
Cdd:pfam19440 262 IARQLAEVLLRGVCEQSYWNPLEDPPPQSLLDEPL-KGTNTKNYTPSRKPRVYSGENIFCPQDNVEEALLLLLISESMAN 340

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 119601842  321 RDAVLSRIPEHKSDRLISLQSASVVYDLLTIALGRRGQYEMLSECL 366
Cdd:pfam19440 341 RDAVLSRSPEHREARIISLQNATAVYDLLTIAMGRRGQYEMLSECL 386
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
692-825 4.86e-20

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 90.45  E-value: 4.86e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 692 LAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALIL 771
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 119601842 772 HQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELE 825
Cdd:COG0457   87 QALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELD 140
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 690-831 1.81e-19

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 93.52  E-value: 1.81e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 690 MTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLAL 769
Cdd:COG3914   75 LLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGE 154

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119601842 770 ILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAV 831
Cdd:COG3914  155 ALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADA 216
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 693-826 3.02e-17

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 79.08  E-value: 3.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 693 AQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILH 772
Cdd:COG4783    4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALL 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 119601842 773 QLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEA 826
Cdd:COG4783   84 KAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
693-826 1.47e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 77.35  E-value: 1.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 693 AQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILH 772
Cdd:COG0457   42 AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALL 121

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 119601842 773 QLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEA 826
Cdd:COG0457  122 ELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAAL 175
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
722-831 6.05e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 75.43  E-value: 6.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 722 LFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGL 801
Cdd:COG0457    3 LDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNL 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 119601842 802 GEVLQAQGNDAAATECFLTALELEASSPAV 831
Cdd:COG0457   83 GLALQALGRYEEALEDYDKALELDPDDAEA 112
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 693-831 1.51e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 74.77  E-value: 1.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 693 AQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILH 772
Cdd:COG2956  110 AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYL 189

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 119601842 773 QLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAV 831
Cdd:COG2956  190 EQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLL 248
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 657-831 2.03e-14

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 77.34  E-value: 2.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 657 ATSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQI 736
Cdd:COG3914    8 ALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 737 AELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATE 816
Cdd:COG3914   88 LQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIA 167

                        170
                 ....*....|....*
gi 119601842 817 CFLTALELEASSPAV 831
Cdd:COG3914  168 ALRRALELDPDNAEA 182
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 693-823 5.46e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 73.22  E-value: 5.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 693 AQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILH 772
Cdd:COG2956  144 AHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYE 223

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 119601842 773 QLGRYSLAEKILRDAVQVNSTAhEVWNGLGEVLQAQGNDAAATECFLTALE 823
Cdd:COG2956  224 KLGDPEEALELLRKALELDPSD-DLLLALADLLERKEGLEAALALLERQLR 273
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 729-835 7.22e-14

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 69.45  E-value: 7.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 729 VLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQ 808
Cdd:COG4783    6 ALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKA 85

                         90       100
                 ....*....|....*....|....*..
gi 119601842 809 GNDAAATECFLTALELEASSPAVPFTI 835
Cdd:COG4783   86 GDYDEALALLEKALKLDPEHPEAYLRL 112
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 693-831 1.86e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 71.68  E-value: 1.86e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 693 AQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILH 772
Cdd:COG2956   76 AEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYL 155

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 119601842 773 QLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAV 831
Cdd:COG2956  156 EQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPA 214
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 693-831 7.03e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 69.76  E-value: 7.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 693 AQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILH 772
Cdd:COG2956   42 VEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYE 121

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 119601842 773 QLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAV 831
Cdd:COG2956  122 QEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARA 180
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 696-824 1.32e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 68.99  E-value: 1.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 696 WLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLG 775
Cdd:COG2956   11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 119601842 776 RYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALEL 824
Cdd:COG2956   91 LLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKL 139
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 693-791 7.06e-12

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 63.49  E-value: 7.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 693 AQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILH 772
Cdd:COG4235   17 AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAF 96

                         90
                 ....*....|....*....
gi 119601842 773 QLGRYSLAEKILRDAVQVN 791
Cdd:COG4235   97 QQGDYAEAIAAWQKLLALL 115
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 693-835 1.51e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 68.10  E-value: 1.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 693 AQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILH 772
Cdd:COG3914  112 AEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQ 191

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119601842 773 QLGRYSLAEKILRDAVQVNSTAHEVW-NGLGEVLQAQGNDAAATECFLTALELEASSPAVPFTI 835
Cdd:COG3914  192 DLGRLEEAIAAYRRALELDPDNADAHsNLLFALRQACDWEVYDRFEELLAALARGPSELSPFAL 255
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
736-827 3.27e-11

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 60.18  E-value: 3.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 736 IAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKiLRDAVQVNSTAHEVWNGLGEVLQAQGNDAAAT 815
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEAL 79

                         90
                 ....*....|..
gi 119601842 816 ECFLTALELEAS 827
Cdd:COG3063   80 AYLERALELDPS 91
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 351-591 3.61e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 64.75  E-value: 3.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 351 IALG----RRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLH 426
Cdd:COG2956   46 LALGnlyrRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGD 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 427 WlEEAEKFAKTVVDVGEKTSEFkakgYLALGLTYSLQATDAslrgmqevlqrKALLAFQRAHSLSPTDHQAAFYLALQLA 506
Cdd:COG2956  126 W-EKAIEVLERLLKLGPENAHA----YCELAELYLEQGDYD-----------EAIEALEKALKLDPDCARALLLLAELYL 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 507 ISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENfILLFSKVKLQSLCRGPDEALLTC 586
Cdd:COG2956  190 EQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSD-DLLLALADLLERKEGLEAALALL 268


                 ....*
gi 119601842 587 KHMLQ 591
Cdd:COG2956  269 ERQLR 273
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 661-791 6.83e-11

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 61.51  E-value: 6.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 661 AASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELR 740
Cdd:COG5010   22 TLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRS 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 119601842 741 GSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVN 791
Cdd:COG5010  102 GDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 711-824 9.09e-11

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 60.40  E-value: 9.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 711 EATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQV 790
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 119601842 791 NSTAHEVWNGLGEVLQAQGNDAAATECFLTALEL 824
Cdd:COG4235   81 DPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLAL 114
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
702-796 2.15e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 57.87  E-value: 2.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 702 VYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRwYEEALAISPTHVKSMQRLALILHQLGRYSLAE 781
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEAL 79

                         90
                 ....*....|....*
gi 119601842 782 KILRDAVQVNSTAHE 796
Cdd:COG3063   80 AYLERALELDPSALR 94
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 736-825 3.78e-10

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 59.20  E-value: 3.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 736 IAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAAT 815
Cdd:COG5010   63 LYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAK 142

                         90
                 ....*....|
gi 119601842 816 ECFLTALELE 825
Cdd:COG5010  143 AALQRALGTS 152
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 380-592 1.35e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.13  E-value: 1.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 380 WYQFALSLMAAGKSARAVKVLKECIRLKPDDAtipllAAKLCMGSLHW----LEEAEKFAKTVVDVGEKtsefKAKGYLA 455
Cdd:COG2956   11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETV-----EAHLALGNLYRrrgeYDRAIRIHQKLLERDPD----RAEALLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 456 LGLTYslqatdaslrgMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLL 535
Cdd:COG2956   82 LAQDY-----------LKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCEL 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 119601842 536 ALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEALLTCKHMLQI 592
Cdd:COG2956  151 AELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQ 207
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 323-831 1.91e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 61.25  E-value: 1.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  323 AVLSRIPEHksdrLISLQSASvvydlltIALGRRGQYEMLSECLERAMKfAFEEFHLWYQF-ALSLMAAGKSARAVKVLK 401
Cdd:TIGR02917 286 DALKSAPEY----LPALLLAG-------ASEYQLGNLEQAYQYLNQILK-YAPNSHQARRLlASIQLRLGRVDEAIATLS 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  402 ECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKtvvdVGEKTSEFKAKgYLALGLTYSLQATdaslrgmqevlQRKAL 481
Cdd:TIGR02917 354 PALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAK----ATELDPENAAA-RTQLGISKLSQGD-----------PSEAI 417

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  482 LAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPE 561
Cdd:TIGR02917 418 ADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPD 497

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  562 NFILLFSKVKLQSLCRGPDEALLTCKHMLQIwkscynltNPSDSG---RGSSLLDRTIADRRQLNTITLPDFSDPETGNs 638
Cdd:TIGR02917 498 FFPAAANLARIDIQEGNPDDAIQRFEKVLTI--------DPKNLRailALAGLYLRTGNEEEAVAWLEKAAELNPQEIE- 568

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  639 peayfhgfPSLFSVSSVhatsVAASRVEQALsEVASSLQSSAPKQgplhpwmtlAQIWLHAAEVYIGIGKPAEATACTQE 718
Cdd:TIGR02917 569 --------PALALAQYY----LGKGQLKKAL-AILNEAADAAPDS---------PEAWLMLGRAQLAAGDLNKAVSSFKK 626

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  719 AANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVW 798
Cdd:TIGR02917 627 LLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGF 706

                         490       500       510
                  ....*....|....*....|....*....|...
gi 119601842  799 NGLGEVLQAQGNDAAATECFLTALELEASSPAV 831
Cdd:TIGR02917 707 ELEGDLYLRQKDYPAAIQAYRKALKRAPSSQNA 739
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 693-833 2.43e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 61.25  E-value: 2.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  693 AQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELR-GSMDEARRWYEEALAISPTHVKSMQRLALIL 771
Cdd:TIGR02917  90 NQVLPLLARAYLLQGKFQQVLDELPGKTLLDDEGAAELLALRGLAYLGlGQLELAQKSYEQALAIDPRSLYAKLGLAQLA 169

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119601842  772 HQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAVPF 833
Cdd:TIGR02917 170 LAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLL 231
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 666-839 3.03e-09

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 60.38  E-value: 3.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  666 EQALSEVASSLQssapkqgpLHPWMTlaQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDE 745
Cdd:TIGR00990 348 LEALADLSKSIE--------LDPRVT--QSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQ 417

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  746 ARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELE 825
Cdd:TIGR00990 418 AGKDYQKSIDLDPDFIFSHIQLGVTQYKEGSIASSMATFRRCKKNFPEAPDVYNYYGELLLDQNKFDEAIEKFDTAIELE 497

                         170
                  ....*....|....
gi 119601842  826 ASSPAVPFTIIPRV 839
Cdd:TIGR00990 498 KETKPMYMNVLPLI 511
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
345-566 4.50e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.09  E-value: 4.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 345 VYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIpLLAAKLCMGS 424
Cdd:COG0457   10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA-LNNLGLALQA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 425 LHWLEEAEKFAKTVVDVGEKtsefKAKGYLALGLTYSLQatdaslrGMQEvlqrKALLAFQRAHSLSPTDHQAAFYLALQ 504
Cdd:COG0457   89 LGRYEEALEDYDKALELDPD----DAEALYNLGLALLEL-------GRYD----EAIEAYERALELDPDDADALYNLGIA 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119601842 505 LAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILL 566
Cdd:COG0457  154 LEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILT 215
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 731-831 1.35e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.05  E-value: 1.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 731 YMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGN 810
Cdd:COG2956   12 YFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGL 91

                         90       100
                 ....*....|....*....|.
gi 119601842 811 DAAATECFLTALELEASSPAV 831
Cdd:COG2956   92 LDRAEELLEKLLELDPDDAEA 112
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
678-823 1.38e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 56.08  E-value: 1.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 678 SSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAIS 757
Cdd:COG4785   58 LAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELD 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 758 PTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHE--VWNGL------------------GEVLQAQGNDAAATEC 817
Cdd:COG4785  138 PDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPEraLWLYLaerkldpekalallledwATAYLLQGDTEEAREL 217


                 ....*.
gi 119601842 818 FLTALE 823
Cdd:COG4785  218 FKLALA 223
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 347-831 2.37e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.79  E-value: 2.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  347 DLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDdatipLLAAKLCMGSLH 426
Cdd:TIGR02917 367 SLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLDPE-----LGRADLLLILSY 441

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  427 WLEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTYSLQATDAslrgmqevlqrKALLAFQRAHSLSPTDHQAAFYLAlQLA 506
Cdd:TIGR02917 442 LRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLA-----------KAREAFEKALSIEPDFFPAAANLA-RID 509

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  507 ISR-QIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEALLT 585
Cdd:TIGR02917 510 IQEgNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAI 589

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  586 CKHMLQIWKscynltnpsDSGRGSSLLDRTIADRRQLNTItLPDFSDPETGNSPEAyfhgfPSLFSVSSVHATsvaASRV 665
Cdd:TIGR02917 590 LNEAADAAP---------DSPEAWLMLGRAQLAAGDLNKA-VSSFKKLLALQPDSA-----LALLLLADAYAV---MKNY 651

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  666 EQALSEVASSLQssapkqgpLHPWMTLAQIWLhaAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDE 745
Cdd:TIGR02917 652 AKAITSLKRALE--------LKPDNTEAQIGL--AQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPA 721

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  746 ARRWYEEALAISPTHVKSMQrLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELE 825
Cdd:TIGR02917 722 AIQAYRKALKRAPSSQNAIK-LHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKA 800


                  ....*.
gi 119601842  826 ASSPAV 831
Cdd:TIGR02917 801 PDNAVV 806
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 387-830 4.26e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.02  E-value: 4.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  387 LMAAGKSARAVKVLKECIRLKPDDATiPLLAAKLCMGSLHWLEEAEKFAKTVVDvgektsefKAKGylalgltySLQAtd 466
Cdd:TIGR02917 203 LLSLGNIELALAAYRKAIALRPNNIA-VLLALATILIEAGEFEEAEKHADALLK--------KAPN--------SPLA-- 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  467 ASLRGMQEVLQRK---ALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQK 543
Cdd:TIGR02917 264 HYLKALVDFQKKNyedARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLG 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  544 HYHDALNII--------------DMALSEY-----PENFILLFSKVKLQSlcrgPDEALL-TCKHMLQIwkscynLTNPS 603
Cdd:TIGR02917 344 RVDEAIATLspalgldpddpaalSLLGEAYlalgdFEKAAEYLAKATELD----PENAAArTQLGISKL------SQGDP 413

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  604 DSGrgsslldrtIADRRQLNTItlpdfsDPETGNSpeayfhgfpSLFSVSSvhatSVAASRVEQALSeVASSLQSSAPKQ 683
Cdd:TIGR02917 414 SEA---------IADLETAAQL------DPELGRA---------DLLLILS----YLRSGQFDKALA-AAKKLEKKQPDN 464

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  684 gplhpwmtlAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKS 763
Cdd:TIGR02917 465 ---------ASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRA 535

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119601842  764 MQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPA 830
Cdd:TIGR02917 536 ILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPE 602
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 480-592 8.10e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 56.15  E-value: 8.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 480 ALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEY 559
Cdd:COG3914   97 ALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELD 176

                         90       100       110
                 ....*....|....*....|....*....|...
gi 119601842 560 PENFILLFSKVKLQSLCRGPDEALLTCKHMLQI 592
Cdd:COG3914  177 PDNAEALNNLGNALQDLGRLEEAIAAYRRALEL 209
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
754-831 1.03e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.86  E-value: 1.03e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119601842 754 LAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAV 831
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA 78
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 692-799 8.11e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 52.69  E-value: 8.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 692 LAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALIL 771
Cdd:COG3914  145 FAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFAL 224

                         90       100
                 ....*....|....*....|....*...
gi 119601842 772 HQLGRYSLAEKILRDAVQVNSTAHEVWN 799
Cdd:COG3914  225 RQACDWEVYDRFEELLAALARGPSELSP 252
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 335-515 9.55e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 52.69  E-value: 9.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 335 RLISLQSASV-VYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATI 413
Cdd:COG3914  103 RALALNPDNAeALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEA 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 414 PLLAAKLCMgSLHWLEEAEKFAKTVVDVgeKTSEFKAKGYLALGLTYSL--QATDASLRGMQEVLQRKALLAFQRAHSLS 491
Cdd:COG3914  183 LNNLGNALQ-DLGRLEEAIAAYRRALEL--DPDNADAHSNLLFALRQACdwEVYDRFEELLAALARGPSELSPFALLYLP 259

                        170       180
                 ....*....|....*....|....
gi 119601842 492 PTDhqAAFYLALQLAISRQIPEAL 515
Cdd:COG3914  260 DDD--PAELLALARAWAQLVAAAA 281
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 339-529 1.44e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.92  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 339 LQSASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIpllaa 418
Cdd:COG3914   74 LLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEA----- 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 419 klcmgslhwleeaekfaktvvdvgektsefkakgYLALGLTYSlqatdaSLRGMQEvlqrkALLAFQRAHSLSPTDHQAA 498
Cdd:COG3914  149 ----------------------------------YLNLGEALR------RLGRLEE-----AIAALRRALELDPDNAEAL 183

                        170       180       190
                 ....*....|....*....|....*....|.
gi 119601842 499 FYLALQLAISRQIPEALGYVRQALQLQGDDA 529
Cdd:COG3914  184 NNLGNALQDLGRLEEAIAAYRRALELDPDNA 214
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 479-562 2.78e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 47.31  E-value: 2.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 479 KALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSE 558
Cdd:COG4235   35 EALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLAL 114


                 ....
gi 119601842 559 YPEN 562
Cdd:COG4235  115 LPAD 118
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 693-770 1.17e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 45.77  E-value: 1.17e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119601842 693 AQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALI 770
Cdd:COG4235   51 ADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEASI 128
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 364-530 1.20e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 45.38  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 364 ECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIpllaaklcmgslhwleeaekfaktvvdvge 443
Cdd:COG4235    4 ARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADA------------------------------ 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 444 ktsefkakgYLALGLTYSLQATDAslrgmqevlqrKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQ 523
Cdd:COG4235   54 ---------LLDLAEALLAAGDTE-----------EAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLA 113


                 ....*..
gi 119601842 524 LQGDDAN 530
Cdd:COG4235  114 LLPADAP 120
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 707-789 1.39e-05

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 44.98  E-value: 1.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 707 GKPAEATACTQEAANLFPMSH---NVLYMRGQIAELRGSMDEARRWYEEALAISPTHVK---SMQRLALILHQLGRYSLA 780
Cdd:COG1729    7 GDYDEAIAAFKAFLKRYPNSPlapDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdALLKLGLSYLELGDYDKA 86


                 ....*....
gi 119601842 781 EKILRDAVQ 789
Cdd:COG1729   87 RATLEELIK 95
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 334-436 1.64e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.57  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 334 DRLISLQSASV-VYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDAT 412
Cdd:COG4783   28 EKALELDPDNPeAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPE 107

                         90       100
                 ....*....|....*....|....
gi 119601842 413 IPLLAAKLCMGSLHWLEEAEKFAK 436
Cdd:COG4783  108 AYLRLARAYRALGRPDEAIAALEK 131
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 380-528 3.70e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.41  E-value: 3.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 380 WYQFALSLMAAGKSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLHWlEEAEKFAKTVVDVGEKTSEFkakgYLALGLT 459
Cdd:COG4783    7 LYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDL-DEAIVLLHEALELDPDEPEA----RLNLGLA 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119601842 460 YSLQatdaslrGMQEvlqrKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDD 528
Cdd:COG4783   82 LLKA-------GDYD----EALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 478-592 6.57e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.64  E-value: 6.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 478 RKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALS 557
Cdd:COG4783   21 DEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALK 100

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 119601842 558 EYPENFILLFSKVKLQSLCRGPDEALLTCKHMLQI 592
Cdd:COG4783  101 LDPEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 745-831 7.22e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 43.80  E-value: 7.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 745 EARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALEL 824
Cdd:COG5010   38 KEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALAL 117


                 ....*..
gi 119601842 825 EASSPAV 831
Cdd:COG5010  118 SPDNPNA 124
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
730-829 8.21e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 44.91  E-value: 8.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 730 LYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQG 809
Cdd:COG4785   76 YYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLG 155

                         90       100
                 ....*....|....*....|
gi 119601842 810 NDAAATECFLTALELEASSP 829
Cdd:COG4785  156 RYELAIADLEKALELDPNDP 175
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
380-583 8.27e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.00  E-value: 8.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 380 WYQFALSLMAAGKSARAVKVLKECIRLKPDDATIpllaaklcmgslhwleeaekfaktvvdvgektsefkakgYLALGLT 459
Cdd:COG0457   11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEA---------------------------------------LYNLGLA 51

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 460 YSLQatdaslrGMQEvlqrKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLL 539
Cdd:COG0457   52 YLRL-------GRYE----EALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLAL 120

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 119601842 540 SAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEAL 583
Cdd:COG0457  121 LELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEAL 164
LcrH_SycD TIGR02552
type III secretion low calcium response chaperone LcrH/SycD; Genes in this family are found in ...
 766-833 1.26e-04

type III secretion low calcium response chaperone LcrH/SycD; Genes in this family are found in type III secretion operons. LcrH, from Yersinia is believed to have a regulatory function in the low-calcium response of the secretion system. The same protein is also known as SycD (SYC = Specific Yop Chaperone) for its chaperone role. In Pseudomonas, where the homolog is known as PcrH, the chaperone role has been demonstrated and the regulatory role appears to be absent. ScyD/LcrH contains three central tetratricopeptide-like repeats that are predicted to fold into an all-alpha-helical array.


Pssm-ID: 274197 [Multi-domain]  Cd Length: 135  Bit Score: 42.67  E-value: 1.26e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119601842  766 RLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAVPF 833
Cdd:TIGR02552  22 ALAYNLYQQGRYDEALKLFQLLAAYDPYNSRYWLGLAACCQMLKEYEEAIDAYALAAALDPDDPRPYF 89
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 479-560 1.28e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 43.03  E-value: 1.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 479 KALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSE 558
Cdd:COG5010   72 ESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGT 151


                 ..
gi 119601842 559 YP 560
Cdd:COG5010  152 SP 153
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 348-566 1.41e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.37  E-value: 1.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 348 LLTIALGRRGQYEMLSECLERAMKFAFEEFH---------LWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIPLLAA 418
Cdd:COG3914    6 LLALAALAAAALLAAAAAAELALAAELEAAAlaaalglalLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 419 KLCMgSLHWLEEAEKFAKTVVDVGEKTsefkAKGYLALGLTYSLQATDAslrgmqevlqrKALLAFQRAHSLSPTDHQAA 498
Cdd:COG3914   86 LLLQ-ALGRYEEALALYRRALALNPDN----AEALFNLGNLLLALGRLE-----------EALAALRRALALNPDFAEAY 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119601842 499 FYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILL 566
Cdd:COG3914  150 LNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAH 217
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
693-758 1.76e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 41.31  E-value: 1.76e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119601842 693 AQIWLHAAEVYIGIGKPAEATACtQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISP 758
Cdd:COG3063   26 ADALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDP 90
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 306-413 1.76e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.64  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 306 EEALLLLLISESMANRDAVLSRIPEHKSDRLISLQSASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFAL 385
Cdd:COG5010   17 LTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLAL 96

                         90       100
                 ....*....|....*....|....*...
gi 119601842 386 SLMAAGKSARAVKVLKECIRLKPDDATI 413
Cdd:COG5010   97 LYSRSGDKDEAKEYYEKALALSPDNPNA 124
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 479-562 2.05e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.10  E-value: 2.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 479 KALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSE 558
Cdd:COG4783   56 EAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135


                 ....
gi 119601842 559 YPEN 562
Cdd:COG4783  136 DPDD 139
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 693-831 7.91e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 7.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  693 AQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILH 772
Cdd:TIGR02917 736 SQNAIKLHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLAWLYL 815

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119601842  773 QLGR---YSLAEKilrdAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAV 831
Cdd:TIGR02917 816 ELKDpraLEYAER----ALKLAPNIPAILDTLGWLLVEKGEADRALPLLRKAVNIAPEAAAI 873
PRK12370 PRK12370
HilA/EilA family virulence transcriptional regulator;
395-525 9.75e-04

HilA/EilA family virulence transcriptional regulator;


Pssm-ID: 237080 [Multi-domain]  Cd Length: 553  Bit Score: 42.53  E-value: 9.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 395 RAVKVLKECIRLKPDDaTIPLLAAKLCMGSLHWL--EEAEKFAKTVVDVGEKTSEFKAKGYLALGLTyslqATDASLRGM 472
Cdd:PRK12370 279 QALKLLTQCVNMSPNS-IAPYCALAECYLSMAQMgiFDKQNAMIKAKEHAIKATELDHNNPQALGLL----GLINTIHSE 353

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 119601842 473 QEVlqrkALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQ 525
Cdd:PRK12370 354 YIV----GSLLFKQANLLSPISADIKYYYGWNLFMAGQLEEALQTINECLKLD 402
pgaA PRK10049
outer membrane protein PgaA; Provisional
 462-583 1.24e-03

outer membrane protein PgaA; Provisional


Pssm-ID: 236644 [Multi-domain]  Cd Length: 765  Bit Score: 42.40  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 462 LQATDASLRGMQEvlQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSA 541
Cdd:PRK10049  52 YAAVAVAYRNLKQ--WQNSLTLWQKALSLEPQNDDYQRGLILTLADAGQYDEALVKAKQLVSGAPDKANLLALAYVYKRA 129

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 119601842 542 QKHYhDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEAL 583
Cdd:PRK10049 130 GRHW-DELRAMTQALPRAPQTQQYPTEYVQALRNNRLSAPAL 170
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 661-782 1.32e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  661 AASRVEQALSEVASSLQSSapkqgplhpwMTLAQIwLHAAevyigiGKPAEATACTQEAANLFPMSHNVLYMRGQIAELR 740
Cdd:TIGR02917 144 AQKSYEQALAIDPRSLYAK----------LGLAQL-ALAE------NRFDEARALIDEVLTADPGNVDALLLKGDLLLSL 206

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 119601842  741 GSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEK 782
Cdd:TIGR02917 207 GNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEK 248
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 682-758 1.46e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 39.20  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 682 KQGPLHPWMTLAQIWLhaAEVYIGIGKPAEATACTQEAANLFPMSHNV---LYMRGQIAELRGSMDEARRWYEEALAISP 758
Cdd:COG1729   21 KRYPNSPLAPDALYWL--GEAYYALGDYDEAAEAFEKLLKRYPDSPKApdaLLKLGLSYLELGDYDKARATLEELIKKYP 98
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
345-511 1.68e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.15  E-value: 1.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 345 VYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIpLLAAKLCMGS 424
Cdd:COG0457   78 ALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADA-LYNLGIALEK 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 425 LHWLEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQ 504
Cdd:COG0457  157 LGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLA 236


                 ....*..
gi 119601842 505 LAISRQI 511
Cdd:COG0457  237 ALALYQY 243
TPR_12 pfam13424
Tetratricopeptide repeat;
766-824 1.79e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 37.75  E-value: 1.79e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119601842  766 RLALILHQLGRYSLAEKILRDAVQVNSTAH--------EVWNGLGEVLQAQGNDAAATECFLTALEL 824
Cdd:pfam13424   8 NLAAVLRRLGRYDEALELLEKALEIARRLLgpdhpltaTTLLNLGRLYLELGRYEEALELLERALAL 74
TPR_19 pfam14559
Tetratricopeptide repeat;
741-808 2.38e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 37.18  E-value: 2.38e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119601842  741 GSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNglgevLQAQ 808
Cdd:pfam14559   2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAA-----LLAK 64
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 349-494 3.07e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 3.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 349 LTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIPLLAAkLCMGSLHWL 428
Cdd:COG4783   10 LAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLG-LALLKAGDY 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119601842 429 EEAEKFAKTVVDVGEKTSEFkakgYLALGLTYSLQATDAslrgmqevlqrKALLAFQRAHSLSPTD 494
Cdd:COG4783   89 DEALALLEKALKLDPEHPEA----YLRLARAYRALGRPD-----------EAIAALEKALELDPDD 139
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 703-814 3.09e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.22  E-value: 3.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  703 YIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEK 782
Cdd:TIGR02917 135 YLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALA 214

                          90       100       110
                  ....*....|....*....|....*....|..
gi 119601842  783 ILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAA 814
Cdd:TIGR02917 215 AYRKAIALRPNNIAVLLALATILIEAGEFEEA 246
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 699-760 3.42e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 36.93  E-value: 3.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119601842  699 AAEVYIGIGKPAEATACTQEAA---NLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTH 760
Cdd:pfam13432   3 LARAALRAGDYDDAAAALEAALarfPESPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPGD 67
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 693-760 3.71e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 3.71e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119601842 693 AQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTH 760
Cdd:COG4783   72 PEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 767-833 4.43e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 39.92  E-value: 4.43e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119601842 767 LALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAVPF 833
Cdd:cd24142    6 KAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGYEKY 72
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 479-567 4.56e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.06  E-value: 4.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 479 KALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSE 558
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80


                 ....*....
gi 119601842 559 YPENFILLF 567
Cdd:COG4235   81 DPDNPEALY 89
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 693-758 4.78e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.79  E-value: 4.78e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119601842 693 AQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISP 758
Cdd:COG5010   88 PELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 340-525 5.27e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.71  E-value: 5.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 340 QSASVVYDLLTIALgRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIPLLAAK 419
Cdd:COG2956  108 DDAEALRLLAEIYE-QEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAE 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 420 LCMGSLHWlEEAEKFAKTVVdvgEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAfqrahslsptdhqAAF 499
Cdd:COG2956  187 LYLEQGDY-EEAIAALERAL---EQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDD-------------LLL 249

                        170       180
                 ....*....|....*....|....*.
gi 119601842 500 YLALQLAISRQIPEALGYVRQALQLQ 525
Cdd:COG2956  250 ALADLLERKEGLEAALALLERQLRRH 275
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
479-561 5.46e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.07  E-value: 5.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 479 KALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYvRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSE 558
Cdd:COG3063   10 EAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALEL 88


                 ...
gi 119601842 559 YPE 561
Cdd:COG3063   89 DPS 91
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 381-831 6.20e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 6.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  381 YQFALSLMAAGKSARAVKVLKECIRLKPDDATI-PLLA-AKLCMGSlhwleeaekfAKTVVDVGEKTSEFKAKGYLALgl 458
Cdd:TIGR02917  60 FLLGKIYLALGDYAAAEKELRKALSLGYPKNQVlPLLArAYLLQGK----------FQQVLDELPGKTLLDDEGAAEL-- 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  459 tYSLQATDASLRGMQEVLQRkallAFQRAHSLSPTDHQAAFYLAlQLAISrqipealgyvrqalqlqgddanslhllall 538
Cdd:TIGR02917 128 -LALRGLAYLGLGQLELAQK----SYEQALAIDPRSLYAKLGLA-QLALA------------------------------ 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  539 lsaQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEALLTCKHMLQIwkscynltNPsdsgrgsslldRTIAD 618
Cdd:TIGR02917 172 ---ENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIAL--------RP-----------NNIAV 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  619 RRQLNTITLpdfsdpetgnspeayfhgfpslfsvssvhatsvAASRVEQALSEVASSLqssapKQGPLHPWMTLAQiwlh 698
Cdd:TIGR02917 230 LLALATILI---------------------------------EAGEFEEAEKHADALL-----KKAPNSPLAHYLK---- 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842  699 aAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYS 778
Cdd:TIGR02917 268 -ALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVD 346

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 119601842  779 LAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAV 831
Cdd:TIGR02917 347 EAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAA 399
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 346-418 7.08e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 37.68  E-value: 7.08e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119601842 346 YDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIPLLAA 418
Cdd:COG4235   20 WLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLG 92
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
693-814 8.46e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.83  E-value: 8.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601842 693 AQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILH 772
Cdd:COG0457  110 AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALA 189

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 119601842 773 QLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAA 814
Cdd:COG0457  190 LAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLL 231
TPR_17 pfam13431
Tetratricopeptide repeat;
750-782 8.83e-03

Tetratricopeptide repeat;


Pssm-ID: 433201 [Multi-domain]  Cd Length: 34  Bit Score: 34.44  E-value: 8.83e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 119601842  750 YEEALAISPTHVKSMQRLALILHQLGRYSLAEK 782
Cdd:pfam13431   2 YLKALELDPNNADAYYNLAVLLLELGQSETALQ 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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