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Conserved domains on  [gi|119595563|gb|EAW75157|]
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hCG1641026, isoform CRA_b [Homo sapiens]

Protein Classification

MYT1 and zf-C2HC domain-containing protein( domain architecture ID 10479154)

protein containing domains MYT1, zf-C2HC, and Com_YlbF

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MYT1 super family cl07191
Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) ...
 560-791 1.70e-77

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) of chordates. MYT1 contains C2HC zinc finger domains (pfam01530) and is expressed in developing neurons of the central nervous system where it is involved in the selection of neuronal precursor cells.


The actual alignment was detected with superfamily member pfam08474:

Pssm-ID: 462489 [Multi-domain]  Cd Length: 237  Bit Score: 254.68  E-value: 1.70e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119595563   560 YRPNVAPATPRANLAKELEKFSKVTFDYASFDAQVFGKRMLAPKIQTSETSPKAFQC----------------------- 616
Cdd:pfam08474    1 YRNNVPTTTPRANLAKELEKYSKTSFDYASFDAQVFGKRTLAPKVQGQDTSPKGFDAkkyfckpsspsssltssyapsss 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119595563   617 ------FDYSQDAEAAHMAATAILNLSTRCWEMPENLSTKPQDLPSKSVDIEVDENGTLDLSMHKHRKREnafpsssscS 690
Cdd:pfam08474   81 ssssssYDYTHDMEAAHMAATAILNLSTRCREMPENLSTKPQDLSAKPDDIEVDENGTLDLSMKKNRPRG---------V 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119595563   691 SSPGVKSPDASQRhssTSAPSSSMTSPQSSQASRQDEWDRPLDYTKPSRLREEEpeesepaahsfaSSEADDQEVSEENF 770
Cdd:pfam08474  152 TSGSVLTPLPPMS---PQRQASLLNSRCYQALCAQDCWDLPVDYTKIKRIDEEE------------KEEPEDLDPFQELL 216

                          250       260
                   ....*....|....*....|.
gi 119595563   771 EERKYPGEVTLTNFKLKFLSK 791
Cdd:pfam08474  217 EERKYPGEVTIPSPKPKYPPC 237
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 843-871 1.07e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 74.11  E-value: 1.07e-16
                           10        20
                   ....*....|....*....|....*....
gi 119595563   843 KCPTPGCDGSGHITGNYASHRSLSGCPRA 871
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 799-827 2.32e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 73.34  E-value: 2.32e-16
                           10        20
                   ....*....|....*....|....*....
gi 119595563   799 TCPTPGCDGSGHITGNYASHRSLSGCPLA 827
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 892-920 2.07e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 67.94  E-value: 2.07e-14
                           10        20
                   ....*....|....*....|....*....
gi 119595563   892 KCPVPGCVGLGHISGKYASHRSASGCPLA 920
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 945-973 2.47e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 67.56  E-value: 2.47e-14
                           10        20
                   ....*....|....*....|....*....
gi 119595563   945 TCPTPGCDGSGHANGSFLTHRSLSGCPRA 973
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 485-513 5.55e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.40  E-value: 5.55e-14
                           10        20
                   ....*....|....*....|....*....
gi 119595563   485 KCPTPGCTGQGHVNSNRNTHRSLSGCPIA 513
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 441-467 6.69e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.40  E-value: 6.69e-14
                           10        20
                   ....*....|....*....|....*..
gi 119595563   441 KCPTPGCDGTGHVTGLYPHHRSLSGCP 467
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCP 27
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 30-57 6.88e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.40  E-value: 6.88e-14
                           10        20
                   ....*....|....*....|....*...
gi 119595563    30 CPTPGCTGSGHVRGKYSRHRSLQSCPLA 57
Cdd:pfam01530    2 CPTPGCDGSGHVSGKYATHRSLSGCPYA 29
Mplasa_alph_rch super family cl37461
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 993-1065 1.33e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


The actual alignment was detected with superfamily member TIGR04523:

Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 52.72  E-value: 1.33e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119595563   993 KTSDVLENDEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQ 1065
Cdd:TIGR04523  354 SESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEK 426
 
Name Accession Description Interval E-value
MYT1 pfam08474
Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) ...
 560-791 1.70e-77

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) of chordates. MYT1 contains C2HC zinc finger domains (pfam01530) and is expressed in developing neurons of the central nervous system where it is involved in the selection of neuronal precursor cells.


Pssm-ID: 462489 [Multi-domain]  Cd Length: 237  Bit Score: 254.68  E-value: 1.70e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119595563   560 YRPNVAPATPRANLAKELEKFSKVTFDYASFDAQVFGKRMLAPKIQTSETSPKAFQC----------------------- 616
Cdd:pfam08474    1 YRNNVPTTTPRANLAKELEKYSKTSFDYASFDAQVFGKRTLAPKVQGQDTSPKGFDAkkyfckpsspsssltssyapsss 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119595563   617 ------FDYSQDAEAAHMAATAILNLSTRCWEMPENLSTKPQDLPSKSVDIEVDENGTLDLSMHKHRKREnafpsssscS 690
Cdd:pfam08474   81 ssssssYDYTHDMEAAHMAATAILNLSTRCREMPENLSTKPQDLSAKPDDIEVDENGTLDLSMKKNRPRG---------V 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119595563   691 SSPGVKSPDASQRhssTSAPSSSMTSPQSSQASRQDEWDRPLDYTKPSRLREEEpeesepaahsfaSSEADDQEVSEENF 770
Cdd:pfam08474  152 TSGSVLTPLPPMS---PQRQASLLNSRCYQALCAQDCWDLPVDYTKIKRIDEEE------------KEEPEDLDPFQELL 216

                          250       260
                   ....*....|....*....|.
gi 119595563   771 EERKYPGEVTLTNFKLKFLSK 791
Cdd:pfam08474  217 EERKYPGEVTIPSPKPKYPPC 237
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 843-871 1.07e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 74.11  E-value: 1.07e-16
                           10        20
                   ....*....|....*....|....*....
gi 119595563   843 KCPTPGCDGSGHITGNYASHRSLSGCPRA 871
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 799-827 2.32e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 73.34  E-value: 2.32e-16
                           10        20
                   ....*....|....*....|....*....
gi 119595563   799 TCPTPGCDGSGHITGNYASHRSLSGCPLA 827
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 892-920 2.07e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 67.94  E-value: 2.07e-14
                           10        20
                   ....*....|....*....|....*....
gi 119595563   892 KCPVPGCVGLGHISGKYASHRSASGCPLA 920
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 945-973 2.47e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 67.56  E-value: 2.47e-14
                           10        20
                   ....*....|....*....|....*....
gi 119595563   945 TCPTPGCDGSGHANGSFLTHRSLSGCPRA 973
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 485-513 5.55e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.40  E-value: 5.55e-14
                           10        20
                   ....*....|....*....|....*....
gi 119595563   485 KCPTPGCTGQGHVNSNRNTHRSLSGCPIA 513
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 441-467 6.69e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.40  E-value: 6.69e-14
                           10        20
                   ....*....|....*....|....*..
gi 119595563   441 KCPTPGCDGTGHVTGLYPHHRSLSGCP 467
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCP 27
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 30-57 6.88e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.40  E-value: 6.88e-14
                           10        20
                   ....*....|....*....|....*...
gi 119595563    30 CPTPGCTGSGHVRGKYSRHRSLQSCPLA 57
Cdd:pfam01530    2 CPTPGCDGSGHVSGKYATHRSLSGCPYA 29
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 993-1065 1.33e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 52.72  E-value: 1.33e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119595563   993 KTSDVLENDEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQ 1065
Cdd:TIGR04523  354 SESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEK 426
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1002-1070 2.39e-06

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 51.06  E-value: 2.39e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119595563 1002 EEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQALIQS 1070
Cdd:COG4372   115 EELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQ 183
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
 1001-1050 3.24e-05

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 43.71  E-value: 3.24e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 119595563 1001 DEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEEN-KLIE 1050
Cdd:cd22887    24 EEEIKDLEEELKEKNKANEILNDELIALQIENNLLEEKLRKLQEENdELVE 74
t_SNARE smart00397
Helical region found in SNAREs; All alpha-helical motifs that form twisted and parallel ...
 994-1047 1.92e-03

Helical region found in SNAREs; All alpha-helical motifs that form twisted and parallel four-helix bundles in target soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor proteins. This motif found in "Q-SNAREs".


Pssm-ID: 197699 [Multi-domain]  Cd Length: 66  Bit Score: 37.95  E-value: 1.92e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 119595563    994 TSDVLENDEEIKQLNQEIRDLNESNSEMeAAMVQLQS-QISSMEKNLKNIEEENK 1047
Cdd:smart00397    4 LAREEERDEELEQLEKSIQELKQIFLDM-GTELEEQGeQLDRIEDNVDDADVNLK 57
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 1002-1050 4.14e-03

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 39.53  E-value: 4.14e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 119595563  1002 EEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENK-LIE 1050
Cdd:pfam08614  113 EKLKDREEELREKRKLNQDLQDELVALQLQLNMAEEKLRKLEKENReLVE 162
 
Name Accession Description Interval E-value
MYT1 pfam08474
Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) ...
 560-791 1.70e-77

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) of chordates. MYT1 contains C2HC zinc finger domains (pfam01530) and is expressed in developing neurons of the central nervous system where it is involved in the selection of neuronal precursor cells.


Pssm-ID: 462489 [Multi-domain]  Cd Length: 237  Bit Score: 254.68  E-value: 1.70e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119595563   560 YRPNVAPATPRANLAKELEKFSKVTFDYASFDAQVFGKRMLAPKIQTSETSPKAFQC----------------------- 616
Cdd:pfam08474    1 YRNNVPTTTPRANLAKELEKYSKTSFDYASFDAQVFGKRTLAPKVQGQDTSPKGFDAkkyfckpsspsssltssyapsss 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119595563   617 ------FDYSQDAEAAHMAATAILNLSTRCWEMPENLSTKPQDLPSKSVDIEVDENGTLDLSMHKHRKREnafpsssscS 690
Cdd:pfam08474   81 ssssssYDYTHDMEAAHMAATAILNLSTRCREMPENLSTKPQDLSAKPDDIEVDENGTLDLSMKKNRPRG---------V 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119595563   691 SSPGVKSPDASQRhssTSAPSSSMTSPQSSQASRQDEWDRPLDYTKPSRLREEEpeesepaahsfaSSEADDQEVSEENF 770
Cdd:pfam08474  152 TSGSVLTPLPPMS---PQRQASLLNSRCYQALCAQDCWDLPVDYTKIKRIDEEE------------KEEPEDLDPFQELL 216

                          250       260
                   ....*....|....*....|.
gi 119595563   771 EERKYPGEVTLTNFKLKFLSK 791
Cdd:pfam08474  217 EERKYPGEVTIPSPKPKYPPC 237
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 843-871 1.07e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 74.11  E-value: 1.07e-16
                           10        20
                   ....*....|....*....|....*....
gi 119595563   843 KCPTPGCDGSGHITGNYASHRSLSGCPRA 871
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 799-827 2.32e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 73.34  E-value: 2.32e-16
                           10        20
                   ....*....|....*....|....*....
gi 119595563   799 TCPTPGCDGSGHITGNYASHRSLSGCPLA 827
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 892-920 2.07e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 67.94  E-value: 2.07e-14
                           10        20
                   ....*....|....*....|....*....
gi 119595563   892 KCPVPGCVGLGHISGKYASHRSASGCPLA 920
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 945-973 2.47e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 67.56  E-value: 2.47e-14
                           10        20
                   ....*....|....*....|....*....
gi 119595563   945 TCPTPGCDGSGHANGSFLTHRSLSGCPRA 973
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 485-513 5.55e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.40  E-value: 5.55e-14
                           10        20
                   ....*....|....*....|....*....
gi 119595563   485 KCPTPGCTGQGHVNSNRNTHRSLSGCPIA 513
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 441-467 6.69e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.40  E-value: 6.69e-14
                           10        20
                   ....*....|....*....|....*..
gi 119595563   441 KCPTPGCDGTGHVTGLYPHHRSLSGCP 467
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCP 27
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 30-57 6.88e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.40  E-value: 6.88e-14
                           10        20
                   ....*....|....*....|....*...
gi 119595563    30 CPTPGCTGSGHVRGKYSRHRSLQSCPLA 57
Cdd:pfam01530    2 CPTPGCDGSGHVSGKYATHRSLSGCPYA 29
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 993-1065 1.33e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 52.72  E-value: 1.33e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119595563   993 KTSDVLENDEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQ 1065
Cdd:TIGR04523  354 SESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEK 426
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1002-1070 2.39e-06

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 51.06  E-value: 2.39e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119595563 1002 EEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQALIQS 1070
Cdd:COG4372   115 EELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQ 183
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
 1001-1050 3.24e-05

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 43.71  E-value: 3.24e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 119595563 1001 DEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEEN-KLIE 1050
Cdd:cd22887    24 EEEIKDLEEELKEKNKANEILNDELIALQIENNLLEEKLRKLQEENdELVE 74
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 953-1113 7.52e-05

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 46.94  E-value: 7.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119595563   953 GSGHANGSFLTHRslsgcpratfagKKGKLSGDEVLSPKFKTSDVLENDEEIKQLNQEIRDLNESNSEMEAAMVQLQSQI 1032
Cdd:pfam05667  291 DTGLTKGSRFTHT------------EKLQFTNEAPAATSSPPTKVETEEELQQQREEELEELQEQLEDLESSIQELEKEI 358

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119595563  1033 SSMEKNLKNIEEENKLIEEQNEAL--------------------FLELSGLSQALIQSLANIRL---PHMEPICEQnfda 1089
Cdd:pfam05667  359 KKLESSIKQVEEELEELKEQNEELekqykvkkktldllpdaeenIAKLQALVDASAQRLVELAGqweKHRVPLIEE---- 434

                          170       180
                   ....*....|....*....|....
gi 119595563  1090 yVSTLTDMYSNQDPENKDLLESIK 1113
Cdd:pfam05667  435 -YRALKEAKSNKEDESQRKLEEIK 457
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 978-1112 2.69e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 45.01  E-value: 2.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119595563   978 KKGKLSG--DEVLSPKF-KTSDVLEndEEIKQLNQEIRDLNESNSEMEAAMVQLQ--------------SQISSMEKNLK 1040
Cdd:TIGR04523  536 KESKISDleDELNKDDFeLKKENLE--KEIDEKNKEIEELKQTQKSLKKKQEEKQelidqkekekkdliKEIEEKEKKIS 613

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119595563  1041 NIEEENKLIEEQNEALFLELSGL---SQALIQSLANIRLPhmepiceqnfdayVSTLTDMYSNQDPENKDLLESI 1112
Cdd:TIGR04523  614 SLEKELEKAKKENEKLSSIIKNIkskKNKLKQEVKQIKET-------------IKEIRNKWPEIIKKIKESKTKI 675
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
995-1069 1.37e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.20  E-value: 1.37e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119595563  995 SDVLENDEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQALIQ 1069
Cdd:COG4372    73 SELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAE 147
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 999-1120 1.87e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.06  E-value: 1.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119595563  999 ENDEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQALiqslanirlph 1078
Cdd:COG4942    31 QLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL----------- 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 119595563 1079 mepicEQNFDAYVSTLTDMYSNQDPENKDLL---ESIKQAVRGIQ 1120
Cdd:COG4942   100 -----EAQKEELAELLRALYRLGRQPPLALLlspEDFLDAVRRLQ 139
t_SNARE smart00397
Helical region found in SNAREs; All alpha-helical motifs that form twisted and parallel ...
 994-1047 1.92e-03

Helical region found in SNAREs; All alpha-helical motifs that form twisted and parallel four-helix bundles in target soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor proteins. This motif found in "Q-SNAREs".


Pssm-ID: 197699 [Multi-domain]  Cd Length: 66  Bit Score: 37.95  E-value: 1.92e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 119595563    994 TSDVLENDEEIKQLNQEIRDLNESNSEMeAAMVQLQS-QISSMEKNLKNIEEENK 1047
Cdd:smart00397    4 LAREEERDEELEQLEKSIQELKQIFLDM-GTELEEQGeQLDRIEDNVDDADVNLK 57
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 991-1059 2.63e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.93  E-value: 2.63e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119595563   991 KFKTSDVLENDEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLE 1059
Cdd:TIGR04523  492 KSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKKENLE 560
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
999-1056 3.19e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.04  E-value: 3.19e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 119595563  999 ENDEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEAL 1056
Cdd:COG4372    70 QARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDL 127
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 999-1063 3.49e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.54  E-value: 3.49e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119595563   999 END---EEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGL 1063
Cdd:TIGR04523  378 ENQsykQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDL 445
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 1002-1050 4.14e-03

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 39.53  E-value: 4.14e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 119595563  1002 EEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENK-LIE 1050
Cdd:pfam08614  113 EKLKDREEELREKRKLNQDLQDELVALQLQLNMAEEKLRKLEKENReLVE 162
SNARE_Qa cd15840
SNARE motif, subgroup Qa; SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein ...
 999-1044 4.61e-03

SNARE motif, subgroup Qa; SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins consist of coiled-coil helices (called SNARE motifs) which mediate the interactions between SNARE proteins, and a transmembrane domain. The SNARE complex mediates membrane fusion, important for trafficking of newly synthesized proteins, recycling of pre-existing proteins and organelle formation. SNARE proteins are classified into four groups, Qa-, Qb-, Qc- and R-SNAREs, depending on whether the residue in the hydrophilic center layer of the four-helical bundle is a glutamine (Q) or arginine (R). Qa-, as well as Qb- and Qc-SNAREs, are localized to target organelle membranes, while R-SNARE is localized to vesicle membranes. They form unique complexes consisting of one member of each subgroup, that mediate fusion between a specific type of vesicles and their target organelle. Their SNARE motifs form twisted and parallel heterotetrameric helix bundles. Examples for members of the Qa SNAREs are syntaxin 18, syntaxin 5, syntaxin 16, and syntaxin 1.


Pssm-ID: 277193 [Multi-domain]  Cd Length: 59  Bit Score: 36.34  E-value: 4.61e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 119595563  999 ENDEEIKQLNQEIRDLNESNSEMeAAMVQLQS-QISSMEKNLKNIEE 1044
Cdd:cd15840     3 EREEEIREIESSIGEVNEIFKDL-ATLVTEQGeQIDNIENNIEEAAA 48
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1002-1120 6.61e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.27  E-value: 6.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119595563 1002 EEIKQLNQEI----RDLNESNSEMEAAMVQL----------QSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQAl 1067
Cdd:COG4372    52 EELEQAREELeqleEELEQARSELEQLEEELeelneqlqaaQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQ- 130

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 119595563 1068 iqslanirlphmepicEQNFDAYVSTLTDMYSNQDPENKDLLESIKQAVRGIQ 1120
Cdd:COG4372   131 ----------------RKQLEAQIAELQSEIAEREEELKELEEQLESLQEELA 167
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1001-1117 7.31e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.20  E-value: 7.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119595563 1001 DEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEknlKNIEEENKLIEEQNEALFleLSGLSQALIQSLANIrlphme 1080
Cdd:COG3883    43 QAELEELNEEYNELQAELEALQAEIDKLQAEIAEAE---AEIEERREELGERARALY--RSGGSVSYLDVLLGS------ 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 119595563 1081 piceQNFDAY---VSTLTDMYSNQdpenKDLLESIKQAVR 1117
Cdd:COG3883   112 ----ESFSDFldrLSALSKIADAD----ADLLEELKADKA 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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