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Conserved domains on  [gi|119595554|gb|EAW75148|]
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transmembrane protein 135, isoform CRA_a [Homo sapiens]

Protein Classification

Tim17/Tim22/Tim23/Pmp24 family protein( domain architecture ID 11240103)

Tim17/Tim22/Tim23/Pmp24 family protein such as the mitochondrial import inner membrane translocase subunit Tim22, an essential core component of the TIM22 complex, which mediates the insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM135_C_rich pfam15982
N-terminal cysteine-rich region of Transmembrane protein 135; TMEM135_C_rich is a family of ...
 9-142 9.40e-75

N-terminal cysteine-rich region of Transmembrane protein 135; TMEM135_C_rich is a family of putative peroxisomal membrane proteins found in eukaryotes. This is the highly conserved N-terminal region that has several highly conserved cysteine residues. The domain is associated with family Tim17, pfam02466.


:

Pssm-ID: 374269  Cd Length: 134  Bit Score: 230.53  E-value: 9.40e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119595554    9 PHNCYEIGHTWHPSCRVSFLQITGGALEESLKIYAPLYLIAAILRKRKLDYYLHKLLPEILQSASFLTANGALYMAFFCI 88
Cdd:pfam15982   1 PHNCYEIGHTWSPSCSQSALDITRSALEESLKIYAPLYLIAAMLRRRKFDYYFRELVPEILRSSSFLTFNGFAVIVFFCF 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 119595554   89 LRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMANLATETLFRMGV 142
Cdd:pfam15982  81 LRRSLGKFYSWLIGFGPALPASYIAILLERKSRRGLLTIYMANLATETLFRMAV 134
Tim17 pfam02466
Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer ...
 299-351 8.77e-07

Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).


:

Pssm-ID: 460567  Cd Length: 109  Bit Score: 47.17  E-value: 8.77e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 119595554  299 QLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGismMFYKSTTISM 351
Cdd:pfam02466  51 SLGNNFAVFGGLYSGIECGLEKYRGKEDPWNSIAAGALTG---ALLRGGPRAA 100
 
Name Accession Description Interval E-value
TMEM135_C_rich pfam15982
N-terminal cysteine-rich region of Transmembrane protein 135; TMEM135_C_rich is a family of ...
 9-142 9.40e-75

N-terminal cysteine-rich region of Transmembrane protein 135; TMEM135_C_rich is a family of putative peroxisomal membrane proteins found in eukaryotes. This is the highly conserved N-terminal region that has several highly conserved cysteine residues. The domain is associated with family Tim17, pfam02466.


Pssm-ID: 374269  Cd Length: 134  Bit Score: 230.53  E-value: 9.40e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119595554    9 PHNCYEIGHTWHPSCRVSFLQITGGALEESLKIYAPLYLIAAILRKRKLDYYLHKLLPEILQSASFLTANGALYMAFFCI 88
Cdd:pfam15982   1 PHNCYEIGHTWSPSCSQSALDITRSALEESLKIYAPLYLIAAMLRRRKFDYYFRELVPEILRSSSFLTFNGFAVIVFFCF 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 119595554   89 LRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMANLATETLFRMGV 142
Cdd:pfam15982  81 LRRSLGKFYSWLIGFGPALPASYIAILLERKSRRGLLTIYMANLATETLFRMAV 134
Tim17 pfam02466
Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer ...
 299-351 8.77e-07

Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).


Pssm-ID: 460567  Cd Length: 109  Bit Score: 47.17  E-value: 8.77e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 119595554  299 QLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGismMFYKSTTISM 351
Cdd:pfam02466  51 SLGNNFAVFGGLYSGIECGLEKYRGKEDPWNSIAAGALTG---ALLRGGPRAA 100
 
Name Accession Description Interval E-value
TMEM135_C_rich pfam15982
N-terminal cysteine-rich region of Transmembrane protein 135; TMEM135_C_rich is a family of ...
 9-142 9.40e-75

N-terminal cysteine-rich region of Transmembrane protein 135; TMEM135_C_rich is a family of putative peroxisomal membrane proteins found in eukaryotes. This is the highly conserved N-terminal region that has several highly conserved cysteine residues. The domain is associated with family Tim17, pfam02466.


Pssm-ID: 374269  Cd Length: 134  Bit Score: 230.53  E-value: 9.40e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119595554    9 PHNCYEIGHTWHPSCRVSFLQITGGALEESLKIYAPLYLIAAILRKRKLDYYLHKLLPEILQSASFLTANGALYMAFFCI 88
Cdd:pfam15982   1 PHNCYEIGHTWSPSCSQSALDITRSALEESLKIYAPLYLIAAMLRRRKFDYYFRELVPEILRSSSFLTFNGFAVIVFFCF 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 119595554   89 LRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMANLATETLFRMGV 142
Cdd:pfam15982  81 LRRSLGKFYSWLIGFGPALPASYIAILLERKSRRGLLTIYMANLATETLFRMAV 134
Tim17 pfam02466
Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer ...
 299-351 8.77e-07

Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).


Pssm-ID: 460567  Cd Length: 109  Bit Score: 47.17  E-value: 8.77e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 119595554  299 QLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGismMFYKSTTISM 351
Cdd:pfam02466  51 SLGNNFAVFGGLYSGIECGLEKYRGKEDPWNSIAAGALTG---ALLRGGPRAA 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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